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If youve suffered from hormonal acne, you know there's no easy fix. And yet, there's a supplement that's starting to garner attention for how well it seems to work. Diindolylmethane, or DIM, is a compound derived from cruciferous vegetables (think: broccoli, cauliflower, brussels sprouts, etc.)but if you cant get enough of it through your diet, it also comes in supplement form.

While it might seem too good to be true that a compound from green veggies could heal hormonal acne, some research indicates that it could even work as well as prescription medications. In fact, Morgan Rabach, MD, dermatologist and Co-Founder of LM Medical in NYC, says that it may work similarly to Spironolactone, a prescription drug dermatologists often recommend to treat hormonal acne.

Experts hypothesize that DIM may help balance hormones by blocking excess testosteroneand when hormones are balanced, hormonal breakouts should, in theory, be diminished. Lets back up a bit: When androgens (aka male hormones like testosterone) and hormone receptors (cells that translate messages to the body) bind together, it causes changes in the skin that can lead to acne.

Think of androgens binding to hormone receptors like a key in a lockthere is a cascade of effects that it unlocks when it happens, says Dr. Rabach. "This includes things like increased oil production in the face, which clogs the pores and leads to acne. In short, when androgens and hormone receptors interact, acne happens, but Spironolactone prevents that from ever happening to begin with.

DIM, as mentioned before, is thought to have the same mechanism as spironolactone. It binds to the androgen receptor so that there's no 'hole' for the androgen 'keys' to bind to," says Dr. Rabach. "When the the two cant bind, then oil isnt increased, and fewer clogged pores means less acne."

Because there is not yet solid data backing up these results or documenting clear dosages to recommend, Dr. Rabach says she's unlikely to recommend DIM in spite of the fact that, anecdotally, it works for many people.

"DIM shows promising results on hormonal acne in some people and may be a viable natural alternative for people that do not want traditional medicine, but there are no randomized placebo controlled studies, so I can't endorse it 100 percent," she says.

One other thing to note: The supplement industry isn't regulated, meaning the FDA doesn't vet products to make sure they contain exactly what they say they do. So, even if research indicated the dosage required for results (which it doesn't), it's hard to say for sure if you'd actually be getting that dosage from supplements you can buy in stores.

New York City-based publicist and blogger Stephanie OQuigley read about DIM online after finding herself lost for options on treating acne. Because it appeared every month at the same time and was mostly centered around her chin, Stephanie strongly suspected it was related to hormonesand no amount of clean pillowcases, salicylic acid or a dairy-free diet, was making a difference.

I started taking 200mg of DIMI'd read online that this was a great starting dose," she says. "After two to three months, I started to see results." After four months, her skin was pretty much clear. I didnt have to worry about waking up with a big whitehead on my chin," she says. "I would get the odd pimple, but for the most part, I felt great about my complexion.

For Stephanie, however, the good results ceased after seven months. There are so many factors that we dont know about each individual who takes DIM, like how is their diet, skin hygiene, stress, etc.," says Dr. Rabach. "One of those factors or a combination can override DIM." Unfortunately, it comes back to the same limitations on our knowledge of DIM's effectiveness and how it works: "There is no good research to explain how long or if DIM will work for everyone in a predictable way," says Dr. Rabach."

While there is no research-backed recommended dosage, anecdotally, some people say taking 100 milligrams twice a day has worked for themthough, of course, you should always consult your dermatologist or doctor before adding a new supplement to your regimen.

If you and your doctor do decide DIM is a good fit for you, Dr. Rabach says the most common side effects to be aware of are nausea, vomiting, bloating, diarrhea, gas, and headaches. It could also darken your urine due to the presence of DIM metabolites that have an amber color. "Individuals who eat large amounts of DIM-containing cruciferous vegetables would notice similarly colored urine," says naturopathic doctor Marcus Laux.

Bottom line: It may be worth a shotif your doctor approves.

While the hard-and-fast data and studies may not be there for DIM, the initial feedback from people who have used it is that it may work very similarly to Spironolactone. Plus, there are multiple personal success stories online. Sound like it might be a good fit for you? Be sure to have a conversation with your doctor first to determine whether it's safe.

Link:
How DIM Supplements Work On Hormonal Acne, According To A Derm - Women's Health

Wild turkeys displaying fields are thinning out as many of the recently fertilized females are now on their nests. Frustrated, polygamous males are walking farther to find the dwindling number of still-unfertilized, potential mates.

Exchanging my shotgun and crossbow for binoculars, I took the opportunity every morning this past week to closely observe the testosterone-driven males bizarre wattles that decorate their necks.

The red, white, and blue, naked, wrinkled and bulgy wattle skin isnt just a patriotic color combination. Its actually a very functional courting ornament for numerous species of male birds, including roosters and pheasants.

Wattles vary greatly. Large wattles correlate with peak maturity, high testosterone levels and good nutrition. They consequently advertise a sexy, healthy male and help turn on females. Young jakes have small, less impressive wattles.

During hot months, those highly vascularized pouches of skin, which are then predominantly white, can also help reflect and release heat. And now, when males are breeding, blood flow can engorge them so much in moments of excitement that they turn fire engine red for even greater sexual attraction. If I werent studying them to write about, Id be putting them on this weeks menu.

Successful turkey hunts have meant many delicious meals of supremely healthy meat that contains no man-injected hormones or anti-biotics that we find ubiquitous on our market shelves. And preparation is easy.

In quickly dressing their birds, many turkey hunters just fillet out the breasts. Most discard the highly tendinous, tough legs. But they shouldnt.

Those tough legs can be surprisingly delicious. I asked both my son and son-in-law, who were each successful in taking turkeys last week, to save their legs for me. Oakham bow hunter Rob Toupin taught me how cooking them and deer shanks in low heat for three to four hours in a crock pot will produce succulent, tender meat that can be easily pulled off the tendons. Dark meat is always more flavorful than white meat.

As for the breasts, its hard to top slicing off broad, thin pieces, then pounding them between wax paper to a uniform, pancake width, which allows for even, quick cooking. Just give them an egg wash, dip them in Panko, and saut them briefly in butter. Theres no simpler, quicker or more delicious way to serve them.

Turkey season continues through May 23. Forest walkers would be prudent to safely wear orange each morning till then.

Creatures of spring

This week, baby robins hatched, and mothers secretly carried away their shells and droppings. Red trilliums blossomed along with apple trees. Newly emergent, highly variable shades of young green thrilled our eyes.

Just as we were drawn outdoors by the high-70-degree temperatures, ants were drawn indoors, exploring countertops and floor board boundaries. Female mosquitoes searched for blood, and blackflies found many human faces to aggravate.

Sitting under a tree for a sundowner by our fire pit, I had several baby caterpillars and other insect larvae fall on me. No wonder the migrant songbirds from the jungles are returning en masse from the tropics.

To our regret, not all the caterpillars are good, though. Reader Pamela Shanley sent in photos of duct tape she just placed around her oak trees to protect them from gypsy moths, which are hatching on the ground right now and climbing up to eat fresh, tender, most nutritious baby leaves. While their population may be down this year, its worth killing every gypsy moth caterpillar we can. A single female can lay from 500-2,000 eggs.

Pamela annually wages war against them, even banding her neighbors together to fight the endless war. She recommends that this week we overlap three or four layers of duct tape around the trees inside out so the sticky part captures the instinctively climbing larvae. Once the tape is full of stuck caterpillars, Pamela applies new strips right over the used tape, which she totally removes from her trees in mid- to late June.

Here come shad

The number of shad passing over the Holyoke dam on the Connecticut River has been very impressive, considering how early the season is. Some 7,291 shad passed over on May 4 alone. Receding water levels helped that first passage last week, but rising flows over the wet weekend forced closure of the fish lift operations again. Interestingly, the COVID-19 challenge has resulted in the implementation of video counts.

The runs duration is much dependent on our weather. Shad will proceed upriver and drop their eggs in place wherever they are when water temperatures are about to get too warm. Its vital that males accompany the females all along their way to eject their sperm at the precise moment that the eggs are laid.

Plenty out fishing

The opening of Wachusett and Quabbin to shore fishermen was celebrated like Fourth of July. Reader Peter Bourneuf reported, Took a ride around the Rez yesterday. Must have been over 300 cars, trucks, and bikes over there. But the fishing has been great. Three- to 4-pound lake trout have been the main prize at Wachusett.

Over on the West River, size 14 black quills have been hatching out along with caddis to provide some excellent dry fly action.

Tuna limits adjusted

Big game recreational fishermen may be surprised to learn that NOAA adjusted the 2020 tuna daily limits. Private, permitted vessels are allowed two bluefin from 27 to less than 47 inches, and one 47 to less than 73 inches. Anglers can additionally catch and release or tag and release bluefin tuna of all size. Were counting on those latter anglers to be ethically responsible and handle those fish in a manner that will maximize their survivability without removing the fish from the water.

Permitted charter boats will now be able to take three school tuna (27-47 inches) and one large tuna 47-73 inches. Head or party boats will be able to take six school tuna and two large ones. Some local charter boat captains think this increased limit is too high and blame the vocal and politically influential charter boat lobby down south.

The commercial limits have yet to be set. Last year was a fiasco. The season opened with a three-fish-per-day limit, which almost instantly flooded the market. A knee-jerk reduction right afterward failed to heal the damage, and prices beneficial to fishermen never rebounded. Some captains would like to see opening week limits set at one fish per day and possibly adjusted sensibly afterwards.

Party and charter boat fishing may open May 18, if all goes best. Those first party boats with large capacities will be fishing mostly for scup and sea bass. They attract many outsiders from the bigger cities. As charter boat captain Bruce Peters shares, There really isnt an effective way to safe distance individuals on these boats. But small charter boats can be very different, and as such, may deserve differential treatment.

Most charter boat customers are families, workmates, and friends, already in close contact with each other," Peters claims. "Our charter boat takes six or fewer people, and are large enough to enable social distances. With masks, there is not a high-risk factor at all.

Peters is hoping that by June, restrictions will be more reasonable.

Good bass

On the striped bass front, cows up to 40 pounds have reached as far north as western Long Island Sound, and faster-moving schoolies already have invaded the New Hampshire coast. Although fluke season doesnt open here until May 23, its open now in New York, Rhode Island and Connecticut.

Lobster pots now

Since the last right whale mothers have taken their babies north out of Cape Cod Bay, lobstermen can now set their pots, and boaters can increase their speeds.

Have some fish

Meanwhile, as pork, chicken and beef supplies from outside our region become less reliable, this is a great time to patronize fish markets and support our local fishermen who can bring us the best fresh haddock, squid, shellfish, scallops, lobster, sea bass, mackerel, striped bass and fluke.

Contact Mark Blazis at markblazissafaris@gmail.com.

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Outdoors: Theres more to turkeys necks than just color - Worcester Telegram

With the recent reports observing the pattern of the coronavirus pandemic, it has been found that while infection rates between men and women are even, in comparison to women, more men die of COVID-19.

Professor Andrea Alimonti of the Universit della Svizzera Italiana-Switzerland said the reason is the presence of male sex hormone, testosterone, and those who are receiving androgen deprivation therapies (ADT) for prostate cancer are less likely to be infected.

ADT administered to patients of prostate cancer heightens their chances of not contracting coronavirus as compared to those who are not on ADT. This therapy is given to prostate cancer patients to reduce testosterone production or blocks its binding to receptors. It works on the observation that cancer cells thrive on male hormones and without its presence they starve, unable to multiply.

And as patients undergoing the treatment have shown less susceptibility to COVID-19, chances are that the reason males are more likely to die than females from the pandemic is the presence of testosterone.

Thetheory was further backed in the Annals of Oncology, by Prof. Alimonti that to date, patients of cancer, including prostate cancer, are at a higher risk of being diagnosed with COVID-19 in Italy's hard-hit Vento region as the disease lowers a bodys defenses.

He found that men with prostate cancer were 1.8 times likely to be diagnosed with COVID-19 as men who dont have cancer. But when the results were compared with the patients who were on ADT, it was found that while men with prostate cancer not on ADT, 0.31 infection rate, men undergoing ADT have a quarter of the mentioned infection rate.

We... have found that those being treated with ADT for prostate cancer are protected, even though all patients with cancer have a greater risk of Covid-19 infection than non-cancer patients, Alimonti said in a statement.

But, even though, Alimonti suggests that men, whether patients of prostate cancer or not, should be given temporary doses of ADT to men, especially those who have a higher risk of catching the virus and assured testosterone levels return to normal once ADT is stopped.

This is an Electron Microscopy of Coronavirus. Murphy Medical Associates

Continued here:
Coronavirus: Men Are Twice As Likely To Die And The Reason Is Testosterone - Latin Times

Acerus Pharmaceuticals

The scope of the Report:

The report analyzes the key opportunities, CAGR, and Y-o-Y growth rates to allow readers to understand all the qualitative and quantitative aspects of the Testosterone Replacement Therapy market. A competition analysis is imperative in the Testosterone Replacement Therapy market and the competition landscape serves this objective. A wide company overview, financials, recent developments, and long and short-term strategies adopted are par for the course. Various parameters have been taken into account while estimating market size. The revenue generated by the leading industry participants in the sales of Testosterone Replacement Therapy across the world has been calculated through primary and secondary research. The Testosterone Replacement Therapy Market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status.

By Regions:

* North America (The US, Canada, and Mexico)

* Europe (Germany, France, the UK, and Rest of the World)

* Asia Pacific (China, Japan, India, and Rest of Asia Pacific)

* Latin America (Brazil and Rest of Latin America.)

* Middle East & Africa (Saudi Arabia, the UAE, , South Africa, and Rest of Middle East & Africa)

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Highlights of the Testosterone Replacement Therapy market study:

Speculations for sales:

The report contains historical revenue and volume that backing information about the market capacity, and it helps to evaluate conjecture numbers for key areas in the Testosterone Replacement Therapy market. Additionally, it includes a share of every segment of the Testosterone Replacement Therapy market, giving methodical information about types and applications of the market.

Key point summary of the Testosterone Replacement Therapy market report:

This report gives a forward-looking prospect of various factors driving or restraining market growth.

It presents an in-depth analysis of changing competition dynamics and puts you ahead of competitors.

It gives a six-year forecast evaluated on the basis of how the market is predicted to grow.

It assists in making informed business decisions by creating a pin-point analysis of market segments and by having complete insights of the Testosterone Replacement Therapy market.

This report helps users in comprehending the key product segments and their future.

Strategic Points Covered in TOC:

Chapter 1: Introduction, market driving force product scope, market risk, market overview, and market opportunities of the global Testosterone Replacement Therapy market

Chapter 2: Evaluating the leading manufacturers of the global Testosterone Replacement Therapy market which consists of its revenue, sales, and price of the products

Chapter 3: Displaying the competitive nature among key manufacturers, with market share, revenue, and sales

Chapter 4: Presenting global Testosterone Replacement Therapy market by regions, market share and with revenue and sales for the projected period

Chapter 5, 6, 7, 8 and 9: To evaluate the market by segments, by countries and by manufacturers with revenue share and sales by key countries in these various regions

Finally, the report global Testosterone Replacement Therapy market describes Testosterone Replacement Therapy industry expansion game plan, the Testosterone Replacement Therapy industry knowledge supply, appendix, analysis findings and the conclusion. It includes a through explanation of the cutting-edging technologies and investments being made to upgrade the existing ones.

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Art House Extra: 'The Road Warrior' Will Rev Your Engine Join our family of curious Kansas Citians

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Folks with an unquenchable thirst for dystopia need look no further than The Road Warrior, a testosterone-fueled chase movie set in a post-apocalyptic Australian outback.

Directed by George Miller and starring a young Mel Gibson, the movie speculates on a bleak future in which society has been destroyed and the only thing of real value is the fuel to keep your motor running. It all makes a certain sense, given the fact that the movie was created in the wake of a succession of oil crises.

Plausible or not, the movie set a new standard for high-speed action. Music buffs should also note that Queen guitarist Brian May did the soundtrack.

Let Art House host John McGrath take it from here in the attached video. Vroom, vroom

Read the original here:
Art House Extra: 'The Road Warrior' Will Rev Your Engine - Flatland

Dear reader, here you will find three stories of transgender and genderqueer students from NYU. All of them embarked on separate journeys of self-discovery and self-acceptance once they found themselves in college. They faced various challenges along the way and preserved in their goal of living at their most authentic selves.

For August, attending NYU was a dream come true.

They had come out as transgender at the beginning of their high school career. NYUs location in Greenwich Village, a hub for the LGBTQ+ movement and home to the Stonewall Inn, presented an exciting experience suited for August.

New York, and NYU by proxy, associates with a queer-friendly climate. At the university, such an environment was created by the clubs and alliances run by and for LGBTQ+ students and staff members from all across the spectrum. Theres also a graduation ceremony that celebrates queer students and The Gender and Sexuality Team at the Student Health Center, helping transgender and gender-nonconforming individuals transition, explore their identities in a safer environment and live as their authentic selves.

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August, now a Steinhardt graduate, turned their tassel at Yankee Stadium last May. They had spent their last four years at NYU coming into themselves as an active member of NYUs LQBTQ+ community and the president of T-Party, a safe space on campus for TGNC individuals.

August saw NYU as their excuse to get as far as physically possible from LA, where they were stuck in an inhibiting home environment with their father, an avid conservative, and their mother, misinformed on LGBTQ+ issues. But, in preparation for the cross-country move, August had a difficult promise to keep.

[My parents] said I was going to NYU if I dont medically transition, August said. My tuition was on the line. I agreed. It was either go to my dream school or not go to my dream school.

With this, August left for New York. Regardless, they were excited for a change in the environment. But they never really intended on keeping their promise to their parents. They spent their first two years getting acclimated to college life, but the promise they made weighed heavy on their mind.

My dysphoria was getting worse, and I was going into such deep depression watching all of my friends transition, August said. Just knowing that there was this thing I could be doing for myself, but there was this arbitrary reason that I couldnt.

Junior year came and August pushed their fear of backlash from their family aside, concerned more with their own happiness and decided to start medically transitioning.

In preparation to medically transition, many transgender individuals decide to take either testosterone or estrogen to develop masculine or feminine traits, respectively, a procedure known as Hormone Replacement Therapy. After completing a blood test at the Student Health Center, it was determined that they were healthy enough to get on testosterone. Hormones can be taken in a variety of ways, including applying a hormone-induced gel on your shoulder or forearm and receiving intramuscular injections. August started taking hormones at the beginning of their junior year in the form of AndroGel gel pumps.

After Augusts parents found out through an insurance company notification, they took August off their insurance plan and presented an ultimatum: If August wanted to stay at NYU, they had to stop taking hormones. August refused and, eventually, their parents agreed to keep paying their tuition if they saw a therapist in the city.

After being on testosterone for nearly two years, August decided to get top surgery, a common type of gender-confirmation surgery which involves breast removal in order to create a masculine chest. With no medical insurance from their parents, August needed alternative payment methods to cover the surgery.Luckily for them, NYUs Consolidated Health Plan partially covered it. The rest came from Augusts GoFundMe, Augusts Transition Fund. Many things changed for August since their surgery, even their relationship with their parents improved.

Things are good between me and my parents right now, I think, August said with a smile. A lot of their transphobia is seeded in fear that me being trans will hinder me in some way. Its up to them to do the work on other people instead of working on me. Working on other people being comfortable with me.

With a coffee cup in her hand, Remy Elliott looks serene. Her saturated pink lipstick seems to be exactly the right shade to match her pale purple blouse. Her mouth forms a slight smile. When she talks, her voice is soft.

Steinhardt Masters in Childhood Education student Elliott publicly came out as transgender during her senior year in college. Elliott began by coming out to her close friends only. Feeling their acceptance of her authentic identity, she made an announcement on Facebook for International Womens Day in March of 2019, hoping to reach her hometown friends, acquaintances and distant family alike.

After years and years of careful thought and reflection, Im so happy to finally announce that I am transgender! Elliotts post reads. From here on out, Ill be living my life as the woman that Ive always been! Id like to be called by my real name, Remy, and not my deadname

Coming out later in her college career bore a lot of challenges for Elliott, externally and internally. While she began mentioning her struggle with her then-cis gender identity to friends around her sophomore year, coming out more publicly took time and seeking for validation from within. Elliott was worried she wasnt transgender enough.

For a long time, I was under the impression that I was trans but will never do anything about it, Elliott said. My dysphoria wasnt so bad that I felt like I was living a lie constantly. I could kind of make it through as a man.

But the pressure grew as the end of college approached. As a senior majoring in education, she had to have a teaching placement and was assigned to teach in a New York primary school last January.

Wishing to enter her new workplace as her real self, Elliott pushed herself to make a switch from masculine to feminine pronouns.

Contributing to the difficulties was the mismatch in the way Elliott felt and the way she was perceived from the outside. For many transgender individuals, theres a distinction between coming out and socially transitioning. For some, the two go hand-in-hand. For others, the choice to do one or the other can be more nuanced, involving difficult financial decisions, possible medical roadblocks including health conditions and considerations, lack of appropriate insurance coverage or potential judgement of those closest to the person. While social transitioning usually involves a name change, after which ones birth name becomes their deadname, and a pronouns switch, medical transitioning involves a multitude of procedures, including hormone replacement therapy and top or bottom surgeries.

Even with her determination to finally come out as a trans-woman, she found it difficult to navigate the resistance in her immediate community. The closest of her friends made the switch with no issues but the majority of the community around her struggled with misgendering and deadnaming Elliott.

Once I started going full-time [as a female] it got easier for people to come to terms with, Elliott said. When I was fluid, people had a harder time wrapping their heads around it.

After coming out, I didnt start transitioning immediately, Elliott said. I kept wearing masculine clothes and went by my deadname for a while.

Later in her senior year, Elliott began experimenting with her appearance, practicing different makeup techniques she enjoyed and building a more feminine wardrobe, discovering what clothes she felt most comfortable in. Towards the end of her senior year, Elliott chose to begin HRT and started taking estrogen with the intention of feminizing her appearance further. As an NYU student, she had Comprehensive Healthcare Plan insurance through Wellfleet, which covered the cost of her HRT.

For the Transgender Day of Visibility celebrated on March 31, Somaya Gupta posted a picture of themselves ready to shave, with the shaving cream on their face and a razor in their hand.

I have a distinct memory of being a kid and watching my dad shave his face and thinking that looks so fun, I wish I could do that, Gupta wrote in the caption. But growing up as a brown girl, I quickly learned that shaving my face was not acceptable One incredible lesson Ive learned through accepting my transness is that the instincts you had as a child were usually right

Gupta, who is graduating from Steinhardt this year, identifies as genderqueer and uses any pronouns. Despite being a senior, Gupta finds themselves in the process of still figuring out the labels they feel most comfortable with and where they fall on the gender spectrum.

At some point during their first year, Gupta and their then-roommate went to a friends dorm. The friend identifies as non-binary. On their way back, Guptas roommate asked what non-binary meant and Gupta explained, ultimately wondering how people ever realized their genderqueerness.

Does anyone ever feel like their gender? Gupta asked. You just say youre a girl because you were told that, right? But she was like no, you feel like a girl and so panic ensued.

In their sophomore year, Gupta, still silently questioning themselves but leaving the thoughts about their gender identity on the backburner, joined Shades, seeking a community of LGBTQ+ people of color who could relate to and understand their intersectional experience.

Throughout their time at NYU, theyve been involved with LGBTQ+ advocacy as the president of Shades LGBTQ+ Centers club for Black queer people and queer people of color and serves as a campus ambassador for GLAAD. While advocating for others, Gupta found themselves on their own journey of self-discovery and self-acceptance.

By their junior year, they had a lot of transgender and genderqueer friends, to whom they related a lot. This allowed them to begin self-discovery without the fear of losing their loved ones.

Junior year, when I came back from winter break, we had our first Shades meeting, Gupta said. We all go around and say our names and pronouns. And I said to everyone, when I usually said she and her, Im not sure so Ill just go with any pronouns. After I said that, a couple of people were like woo, thats cool!

All of Guptas friends were very supportive when they came out to them. So was Guptas older sister, who helped Gupta educate their parents about genderqueer people to avoid possible misunderstandings for whenever Gupta might choose to share their identity with the rest of their family. When they did, their parents accepted their child.

We were on vacation, I knew they would be more relaxed, Gupta laughed. I was saying how in queer spaces it was very common for people to say their pronouns and my mom said well, what pronouns do you say? I [said] yeah, Im genderqueer, and my mom was like, wow, shocker! She knew it was coming.

As a process of their coming out, Gupta began more openly expressing their queerness on social media. They started experimenting with their appearance, cutting their hair because having long hair no longer felt as though it was them. As of late, they have begun posting pictures of the way they changed thanks to the workouts they have taken on to make their body suit their mind better. But medically transitioning by going on testosterone, even though desired, feels like a risk too high to take right now. Guptas a musician and their voice might change in unpredictable ways if they were to start HRT.

So Im taking more time to think about it, what dosage I would need and finding the right doctor for my situation and stuff, Gupta said. I would look forward to being more muscular, my hips being less prominent wider face and neck! I would look forward to mostly just people looking at me and not automatically assuming Im a girl.

For each of these students, their path to becoming and presenting as themselves has been a complex one, and each of them finds themselves at a different place in their journeys.

Right now Gupta is getting ready to graduate, eagerly looking at their future and preparing new music for release. Their single Do You Ever will be available for streaming on May 15. August is currently living in New York as an openly trans person with their dog, Frank. They have fully recovered from their top surgery and model for We Speak Models. Elliott is continuing her journey with NYU as a graduate student, preparing to become an educator and feeling happy to have CHP insurance covering estrogen, which she started last spring as a part of her medical transitioning path.

Just like their transitions, the lives of August, Elliott and Gupta go on.

Correction, May 8:The last name of an individual profiled was removed upon request after publication. This article has been updated to reflect this and WSN regrets any errors.

Email Anna-Dmitry Muratova at [emailprotected] A version of this article appears in the Friday, May 8, 2020, print edition. Read more from Washington Square News While You Were Here 2020.

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Coming to University and Into Their Own - NYU Washington Square News

For most women, perimenopause the transition to menopause begins in their 40s. The entire menopause process typically lasts around four years and begins with the ovaries making less estrogen.

A woman is considered to be post-menopausal when she hasnt experienced a menstrual period for 12 months. This usually occurs between the ages of 46 to 52 years.

Read more: How to make work menopause-friendly: don't think of it as a problem to be managed

Symptoms of menopause can include irregular periods, hot flushes, fatigue, tender breasts, night sweats, vaginal dryness, difficulty sleeping, changes in mood and lower libido.

During menopause, hormonal changes can affect the way fat is distributed in the body, but ageing is more likely to be the cause of any weight gain associated with menopause.

Gaining weight isnt inevitable, though. Theres plenty you can do to combat weight gain as you age.

Certain areas such as your stomach are more prone to weight gain during menopause. This is because the change in hormones, which lead to a higher testosterone-to-estrogen ratio, alters where the body deposits fat. Fat comes off the hips and is deposited around the middle.

But the hormonal changes involved in menopause arent the reason you gain weight.

The weight gain that comes with menopause is a by-product of ageing.

As we age, our body stops working as efficiently as it did before. Muscle mass starts to decrease a process known as sarcopenia and fat begins to increase.

And because muscle mass is one of the determining factors of how fast your metabolism will run, when your muscle mass decreases, your body starts to burn fewer calories at rest. This might make it more challenging to maintain your weight.

Read more: Trick or treat? Alternative therapies for menopause

As we age, we tend to continue with our same food habits but dont increase our activity. In fact, aches and pains can make some people actively decrease theirs.

Not compensating for the ageing process and the change in body composition can lead to weight gain.

And this applies to men too they are just as likely to gain weight due to this process known as sarcopenia.

Due to a change in body fat distribution and increase in waist circumference, menopause can also increase your risk of other health conditions.

Read more: Hot flashes? Night sweats? Progesterone can help reduce symptoms of menopause

Following menopause, your ovaries make very little of the hormones estrogen and progesterone. Estrogen helps to keep your blood vessels dilated relaxed and open which helps keep your cholesterol levels down.

Without estrogen, or with lower quantities, your bad cholesterol (known as low-density lipoprotein or LDL-cholesterol) starts to build up in your arteries. This can increase your risk of heart disease and stroke.

Having less estrogen also results in a loss of bone mass, putting you at risk of the disease osteoporosis, which makes your bones more prone to fractures.

Weight gain associated with ageing is not inevitable. There are a number of things you can do to maintain your weight as you age.

1. Exercise

Incorporate regular daily exercise, with a mixture of intensities and variety of activities. Try to include body-strengthening exercises two days per week.

2. Weigh yourself but not too much

Weigh yourself once a week at the same time and day to monitor the trend over time. Any more than this will only create a fixation with weight. Day-to-day fluctuations in weight are to be expected.

3. Create positive habits

Create positive habits by replacing negative behaviours. For example, instead of mindlessly scrolling through social media of an evening or turning on the TV and comfort-eating, replace it with a positive behaviour, such as learning a new hobby, reading a book or going for a walk.

Read more: How to beat weight gain at menopause

4. Eat more slowly

Eat food away from technological distractions and slow down your food consumption.

Try using a teaspoon or chopsticks and chew your food thoroughly as slowing down your food consumption reduces the quantity consumed.

5. Switch off from technology:

Turn off technology after dusk to improve your sleep. Blue light emission from phones, tablets and other devices tell your brain its day, instead of night, which will keep you awake.

Lack of sleep (less than six hours per night) can compromise your decision-making abilities which might lead you to make unhealthy choices that contribute to weight gain.

6. Curb sugar cravings naturally

If youre craving sugar youre better off reaching for foods naturally high in sugar and fat first. Some great options are fruits, nuts, avocado and 100% nut butters. These foods release the same feel-good chemicals in the brain as processed and fast food and leave us feeling full.

Allow yourself your favourite treats, but keep them to once per week.

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Why do women gain weight during menopause? - The Conversation AU

Guys, if youre having problem with your sexual performance or suffering from erectile dysfunction (ED), get your heart health checked. A study published in the Journal of the Endocrine Society suggested that erectile dysfunction could also be a sign of a mans risk for cardiovascular disease and early death. This risk exists regardless of your testosterone levels. Also Read - Men with erectile dysfunction at high risk of death: Know the factors leading to this problem

Erectile dysfunction, also known as impotence, is characterized by the inability to develop or maintain an erection of the penis during sexual activity. This condition occurs more often in older men, and it is more often linked to low levels of testosterone. In previous studies, low testosterone levels have been linked to a higher risk of death in middle-aged and older men. But those results have been inconsistent, said Dr. Leen Antonio of KU Leuven-University Hospitals in Belgium, the lead researcher on the new study. Also Read - Indiscriminate use of marijuana ups your risk of heart ailments

Dr. Antonios team examined the relationship between hormone levels and sexual function in men. Surprisingly, they found that having erectile dysfunction is a bigger issue than low testosterone levels. Also Read - Not satisfied with your sex life? Some sexual health issues you shouldnt ignore in the New Year

As both vascular disease and low testosterone levels can influence erectile function, sexual symptoms can be an early sign for increased cardiovascular risk and mortality, said Antonio.

Dr. Antonios team analyzed data from nearly 2,000 men ages 40 to 79 in five medical centres. They examined the relationship between their hormone measurements and sexual function. During the average follow-up period of 12.4 years, 25 per cent of the men died. Of the men who died, those with normal testosterone levels and erectile dysfunction had a 51% higher risk of death than those without these symptoms.

They also found that men with low total testosterone levels and sexual symptoms had a higher risk of death compared with men with normal testosterone levels and no sexual symptoms.

Higher risk of early death was found in men with sexual symptoms such as erectile dysfunction and poor morning erections. But the researchers didnt find association of low libido with a higher risk of early death.

In addition to low testosterone levels, erectile dysfunction may result from clogged arteries, or cardiovascular disease, which can impede the blood flow necessary to create an erection. Thats why erectile dysfunction, regardless of testosterone levels, can indicate a risk for heart disease and early death.

According to Dr. Antonio, the blood vessels that provide blood for an erection are smaller than the coronary arteries. This means that when theres a build-up of plaque in the arteries (atherosclerosis) the blood flow in the penile vessels may be affected earlier than in the coronary arteries.

Some other possible causes of erectile dysfunction include

Erectile dysfunction can be both prevented and treated by practicing a healthy lifestyle, Dr. Antonio said. Treating heart disease risk factors such as smoking, high blood pressure, high cholesterol and obesity may also help prevent the sexual disfunction, the researcher suggested.

Antonio noted that sexual symptoms could be an early warning sign of poor or worsening health status as well as an increased risk for cardiovascular disease and mortality.

So, it is important to discuss sexual symptoms with your doctors to identify and treat other cardiovascular risk factors or apparent cardiovascular disease, the study author added.

Published : April 30, 2020 10:54 pm

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Erectile dysfunction is more than a sexual problem - it could be an early sign of cardiovascular disease - TheHealthSite

The ' Testosterone Replacement Therapy market' research report now available with Market Study Report, LLC, is a compilation of pivotal insights pertaining to market size, competitive spectrum, geographical outlook, contender share, and consumption trends of this industry. The report also highlights the key drivers and challenges influencing the revenue graph of this vertical along with strategies adopted by distinguished players to enhance their footprints in the Testosterone Replacement Therapy market.

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The latest report on the Testosterone Replacement Therapy market contains a detailed analysis of this marketplace and entails information about various industry segmentations. According to the report, the market is presumed to amass substantial revenue by the end of the forecast duration while expanding at decent growth rate.

Details regarding the industry size, remuneration potential, and volume share are compiled in the report. It further lists out the drivers and challenges that will impact the growth of Testosterone Replacement Therapy market during the estimated timeframe.

The Testosterone Replacement Therapy market with respect to the geographical terrain:

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Additional highlights from the Testosterone Replacement Therapy market report are enlisted below:

Table of Contents:

Executive Summary: It includes key trends of the Testosterone Replacement Therapy market related to products, applications, and other crucial factors. It also provides analysis of the competitive landscape and CAGR and market size of the Testosterone Replacement Therapy market based on production and revenue.

Production and Consumption by Region: It covers all regional markets to which the research study relates. Prices and key players in addition to production and consumption in each regional market are discussed.

Key Players: Here, the report throws light on financial ratios, pricing structure, production cost, gross profit, sales volume, revenue, and gross margin of leading and prominent companies competing in the Testosterone Replacement Therapy market.

Market Segments: This part of the report discusses about product type and application segments of the Testosterone Replacement Therapy market based on market share, CAGR, market size, and various other factors.

Research Methodology: This section discusses about the research methodology and approach used to prepare the report. It covers data triangulation, market breakdown, market size estimation, and research design and/or programs.

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Some of the Major Highlights of TOC covers:

Chapter 1: Methodology & Scope

Definition and forecast parameters

Methodology and forecast parameters

Data Sources

Chapter 2: Executive Summary

Business trends

Regional trends

Product trends

End-use trends

Chapter 3: Testosterone Replacement Therapy Industry Insights

Industry segmentation

Industry landscape

Vendor matrix

Technological and innovation landscape

Chapter 4: Testosterone Replacement Therapy Market, By Region

Chapter 5: Company Profile

Business Overview

Financial Data

Product Landscape

Strategic Outlook

SWOT Analysis

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Latest Study explores the Testosterone Replacement Therapy Market Witness Highest Growth in near future - AlgosOnline

The United States District Courts for the District of New Jersey and the Southern District of New York recently dismissed putative securities class action complaints filed against life science companies in Smith v. Antares Pharma, Inc., et al. and Schaffer v. Nabriva Therapeutics PLC, et al.[1] The decisions make clear that the duty to disclose, imposed on life science companies by the federal securities laws, does not cover all conceivable information investors may find or consider relevant. Moreover, both courts held life science companies are not prohibited from expressing optimism about the prospects of FDA approval for products simply because of less-than-positive feedback from the regulator during the review process. The decisions, and their implications, are discussed below.

Antares Pharma Complaint

On December 21, 2016, Antares Pharma, Inc. (Antares) announced it submitted a New Drug Application (NDA) with respect to Phase 3 clinical studies, conducted in 2014 and 2015, for a testosterone replacement therapy (TRT) drug called QuickShot Testosterone which is currently marketed as Xyosted. Its stock price increased with the announcement. In October 2017, after Antares announced an October 11 FDA letter identifying deficiencies with the NDA, its common stock fell 37.80%. One week later, the FDA issued a Complete Response Letter (CRL) that rejected the NDA and identified clinically meaningful increases in blood pressure and incidents of depression and suicide. On January 11, 2018, Antares disclosed a 12.7% rate of hypertension observed in one of its Phase 3 studies.

Antares submitted a revised NDA in April 2018, which was approved by the FDA on October 1, 2018 with a black boxed warning for blood pressure increases, as well as warnings for risks of depression and suicide. Plaintiff contends Antaress stock price decreased 3% [o]n the heels of the revelation of approval with the requirement of a black box warning and risk of depression and suicide.

Nabriva Therapeutics Complaint

During the class period, Nabriva Therapeutics PLC (Nabriva) had only two products being considered by the FDA for marketing approval; it was not generating revenues from product sales, and did not expect to, unless one of the two drug candidates received approval. In October 2018, Nabriva filed a NDA with respect to Contepo, a drug intended to treat complicated urinary tract infections; this prompted FDA review, which would conclude with a final decision from the FDA by April 30, 2019. On December 14, 2018, the FDA issued a Form 483 letter[2] identifying inspectional observations it made, after visiting the manufacturing plant, that suggested the plant was not in compliance with applicable standards. Nabriva made several statements regarding the Contepo NDA during the class period, none of which mentioned the FDAs Form 483. Ultimately, the FDA did not approve the Contepo NDA. Instead, it issued a CRL withholding approval based substantially on the issues identified in the Form 483 letter. Upon this news, Nabrivas share price declined over 27%.

On August 16, 2019, Nabriva announced it would resubmit the Contepo NDA after rectifying the issues identified in the CRL. Because resubmission would retrigger a six-month review cycle, the FDA would likely not approve Contepo in 2019. Plaintiff alleged statements Nabriva made during the class period were misleading because they led investors to believe the FDA would approve the Contepo NDA in 2019, even though the Form 483 demonstrated that approval would be delayed beyond that year.

Dismissals of the Complaints

In both cases, the complaints were dismissed in their entireties, emphasizing that a life science companys duty to disclose is not unlimited and that it is not enough to plead that an optimistic forward-looking statement regarding approval prospects or timing of approval turns out to be incorrect.

Duty to Disclose

The Supreme Court has made clear that Section 10(b) of the Securities Exchange Act and Rule 10b5 do not create an affirmative duty to disclose any and all material information. Disclosure is required . . . only when necessary to make . . . statements made, in the light of the circumstances under which they were made, not misleading.[3]

In this vein, the Antares decision rejected plaintiffs argument that the failure to disclose the exact statistical risk of any adverse event was not actionable where the specific adverse event was identified as a common side-effect. The court similarly rejected plaintiffs allegation regarding the failure to provide data demonstrating the adverse event risks of its drug compared to the risks of other TRT treatments on the market, emphasizing that there was no duty to disclose such information unless Antares had disclosed some other comparative safety data that would render this omission misleading.

Puffery

The two dismissals also reiterate that puffery or vague statements of corporate optimism are not actionable under Section 10(b) and Rule 10b-5 because they are so general that a reasonable investor would not rely on them.

For example, the Antares court deemed statements that the drug was found to be safe, showed positive . . . safe data and that nothing unusual occurred regarding the FDAs review of the drug as vague and general statements of optimism. The court explained statements cannot be read in a vacuum, concluding a reasonable investor would understand Antaress statements on the drugs safety in light of the disclosure of adverse events. The Nabriva court similarly held company press release statements describing Contepos NDA submission as another major milestone, and Contepo as a first in class antibiotic, as classic examples of puffery because both are vaguely optimistic descriptions that make no particularly definite assertions of existing fact and thus provide little basis to mislead a reasonable investor.

Forward-Looking Statements

The dismissals also emphasized the protections afforded forward-looking statements under the safe harbor provision of the Private Securities Litigation Reform Act (PSLRA).

The Nabriva court rejected challenges to statements made by the company in its March 12, 2019 10-K regarding the risk of delay in FDA approval. Plaintiff argued that the characterization of the delay as a risk rather than a certainty was misleading in light of the concerns raised in the FDAs December 2018 Form 483 and that as a result the statement was not a forward-looking statement but rather a misstatement of existing fact. The court rejected the contention that the risks identified had already materialized, reasoning that the expected approval date was still over four months away and that the Form 483 reflected interim feedback and not a final decision.

Opinions

In dismissing the complaints, the courts reiterated that interpretations of clinical data are opinions and emphasized the heightened pleading requirements with respect to opinion statements following the Supreme Courts decision in Omnicare.[4]

In Antares, the court rejected plaintiffs argument regarding the falsity of the companys opinion about the physiologically normal benefits of the drug, concluding that plaintiff had failed to allege that the opinion was either objectively or subjectively false. The court explained that incidents of hypertension, depression or suicide did not render false the companys opinion regarding the drugs ability to provide patients with physiologically normal and steady levels of testosterone.

The court also held a statement regarding the positive safety data resulting from the study was an interpretation of the clinical trial data and as such an opinion. It reasoned the statement was not actionable absent facts showing Antares did not honestly believe the studies produced positive safety data and lacked a reasonable basis. [5] Similarly, the court held plaintiff failed to allege Antares lacked a reasonable basis for its opinion that the drug was safe, and noted a failure to allege that Antares was aware of this comparative risk data when [it] made the statement.

Conclusion

Antares and Nabriva are helpful precedents for pharmaceutical companies defending against securities class action lawsuits based on optimistic statements made about products undergoing FDA approval. The decisions emphasize that alleged misstatements cannot be read in a vacuum, and indicate that plaintiffs cannot simply rely on less-than-stellar feedback from the FDA, coupled with statements of corporate optimism made during the drug approval process.

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District Courts In New Jersey And New York Dismiss Securities Class Actions Against Life Science Companies Emphasizing the High Pleading Bar With...

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