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Are you looking to lead an active lifestyle? Whether you want to get stronger, increase muscle function, or just stay in shape, strength, and muscle function are key components of any successful fitness regimen. Strength and muscle function play a major role in our ability to move freely and efficiently throughout daily activities. Not only that, but they also have the potential to prevent injury and improve overall health. In this article, well discuss why strength and muscle function matter for your active lifestyle. Well look at how they help us maintain balance and stability while moving through everyday tasks as well as the benefits of incorporating them into your exercise routine. Well also explore some tips on how best to strengthen muscles safely so that you can reach your goals with minimal risk of injury. So lets dive right in!

One of the most important benefits of strength and muscle function is its ability to improve your balance and stability. This is especially important if youre looking to do activities like running, lifting weights, or even just walking. Strong muscles are necessary for supporting the body in proper form while performing movements. When our bodies are properly supported with strong muscles, it gives us much more control over our movements which decreases our risk of injury. Furthermore, strong muscles can help reduce fatigue during physical activity since they require less energy from the body to move through tasks.

In addition to improving balance and stability, strengthening your muscles can also lead to better overall health. Strong muscles help support our bones, tendons, and ligaments which can reduce the risk of injury or disability. Furthermore, stronger muscles make everyday activities like carrying groceries or climbing stairs much easier on the body since they require less energy output. There is also evidence that strengthening your muscles may improve heart health by increasing circulation and reducing blood pressure levels. For example, a recent study found that lifting weights on a regular basis can help reduce the risk of heart disease. Also, stronger muscles can help improve your posture which is important for avoiding pain and discomfort in the body.

If youre looking to start strengthening your muscles, its important to do so in a safe and effective manner. Here are some tips to help you get started:

Start with low-intensity exercises like walking or light weightlifting using lighter weights. Avoid high-intensity activities until your muscles have had time to adjust to the new routine.

Warm up before any activity by stretching and performing dynamic warmup movements such as squats and lunges. This helps prepare the body for physical activity and prevents injury.

Incorporate rest days into your routine. This allows the muscles to recover and repair between workouts.

Make sure you are eating a balanced diet that is rich in protein, healthy fats, and complex carbohydrates. These nutrients will help fuel muscle growth and repair.

Last but not least, stay hydrated! Staying properly hydrated ensures that the body has enough fluid for optimal performance during physical activity.

The body produces hormones such as testosterone and growth hormone that help to regulate muscle development. Testosterone is primarily responsible for developing strength while growth hormone promotes the synthesis of proteins that are needed for muscle growth and repair. As we age, our bodies naturally produce less of these hormones, making it more difficult to gain or maintain muscle mass. Incorporating activities like weightlifting into your exercise regimen can help stimulate the production of these hormones and promote healthy muscle growth. Additionally, getting adequate sleep is essential for optimizing hormonal production which in turn helps to support healthy muscles.

You can even undergo growth hormone therapy and testosterone replacement therapy if you feel that your levels of these hormones are low. For example, if you are taking Sermorelin then you should make sure you are taking the right Sermorelin dosage to maximize its benefits. Also, your doctor will be able to provide you with other advice on how to optimize the production of these hormones in the body.

Your body needs certain nutrients to build and maintain muscle mass, one of the most important being protein. During exercise, our muscles break down proteins into amino acids which are then used as fuel for your workout. Eating foods that are high in protein can help increase the amount of available fuel your muscles have during physical activity and promote muscle growth afterward. Good sources of protein include meats, fish, eggs, nuts, seeds, legumes, and dairy products. Additionally, supplementing with whey protein can also be a great way to get an extra boost of this nutrient after workouts.

Having more muscle mass can also help boost your metabolism. Your basal metabolic rate (BMR) is the number of calories you need to maintain basic bodily functions like breathing and digestion. Having a higher BMR means that you burn more calories at rest, which can be beneficial for weight loss goals. Additionally, engaging in physical activity regularly helps to keep your muscles active and promotes healthy weight management. This means that the more the muscle mass you have, the higher your metabolic rate will be, making it easier to maintain a healthy weight.

Building and maintaining muscle mass requires a combination of proper nutrition, rest, exercise, and hormone regulation. Eating enough protein is essential for fueling your muscles during physical activity and promoting growth afterward. Additionally, having more muscle mass can help boost your metabolism which makes it easier to maintain a healthy weight. Finally, engaging in activities like weightlifting or undergoing therapies such as testosterone replacement therapy may also be beneficial for optimizing the production of hormones that are responsible for building muscle strength. Ultimately, with the right strategies in place, you should be able to achieve your goals when it comes to gaining lean muscle mass!

Read the rest here:
Why Strength and Muscle Function Matter for Your Active Lifestyle - Alvinology

It was early 2022 when friends here in LA first started sharing their peptide therapy experiences with me. One was on a regimen for fertility in preparation for banking her eggs, another for muscle gains, and yet another for weight loss. The Ozempic controversy had yet to swirl into mainstream consciousness, and I was amazed to hear about their results.

Initially, I spoke with Functional Medicine Nurse Practitioner, Toni Tizon-Damiano of Roots Wellness who offers sermorelin, CJC1295, and semaglutide peptide injections in her practice. Through Toni, I began to learn about the growing promise of peptide therapies to target a wide range of needs from anti-aging to deepened sleep and improved brain health.

As I widened my research, I found that certain top biohackers had been quietly naming peptide injections as an exciting area of progress for years. Insulin, for example, is a peptide and has been around for over 100 years. As is nearly always the case, its taken time and possibly a bit of media controversy for many of the lesser known peptide treatments to become more accessible and better understood.

As the semaglutide (Ozempic) craze has grown, it has triggered valid concerns of a return to diet culture. That craze brought my research to a halt and I hesitated to cover the topic at all. Were on a positive trajectory of body positivity in this decade in a way I hope to see continue.

After polling our readers on Instagram, you let us know that the interest was there, and I decided to publish these insights from three pros, all of whom offer a wide variety of peptide therapies in their practices. Peptide therapies are so promising across an important cross-section of health concerns beyond just weight loss. Across the board, in my look at peptide therapy offerings, Ive found a wide-variety of therapies with claims related to all of the below:

+ Better sleep quality+ Improved immunity+ Improved bone density+ Reduction in body fat+ Increased metabolism+ Increased lean muscle mass+ Accelerated wound healing+ Thicker hair+ Tightening of the skin+ Better athletic recovery+ An overall increase in energy+ Balance with other hormones+ Improved libido and sexual performance+ Improved cognition+ Improved joint pain+ Improved mood

Peptides are not new: A lot of research on peptides has been going on for decades, mostly in Europe, and not the US, acccording to Dr. Jacey Folkers of Joi Womens Wellness, I would assume this is because we have been going through a strong pharmaceutical boom during this time. However, I believe peptides should be a large focus for medicine in the United States moving forward. Unfortunately, Im not confident this will be the case. Hopefully, education and awareness of the benefits of peptides continues to spread so that more and more individuals can experience what they can do for their health and the health of their loved ones.

Were sharing a few of the most notable peptide therapies you should know about below, but first

An important note on Ozempic + Weight Loss:Semaglutide and some other peptides target obesity, appetite control and chronic blood sugar imbalances specifically. While supporting weight loss in obese individuals is key for many preventative health measures, please think twice about any treatment that reduces appetite if medical obesity is not a health issue for you.

Many of us, myself included, actually need more nutrition in our daily diets for optimal health not less. Before approaching any peptide therapy that could effect your appetite, consider working with a nutritionist first to do some personal testing. I recommend long-time TCM contributors Brigid Titgemeier, MS, RDN, LD, IFNCP, holistic nutritionist Kelly LeVeque, and Jennie Miremadi, alicensed integrative clinical nutritionist who also specializes in healing from disordered eating.

Lets start with a few peptides therapies Ive been fascinated to learn more about

SS-31 | According to Dr. Heather Smith-Fernandez of Peptology, SS-31 is a peptide that helps to dysregulate the production of mitochondrial free radical production (mitochondrial-derived ROS) and is therefore being looked as a global anti-aging molecule.

BPC-157 has been experimentally demonstrated to accelerate the healing of many different wounds, including tendon-to-bone healing and superior healing of damaged ligaments. This peptide has been known to exhibit analgesic (pain relieving) characteristics. Those who suffer from discomfort due to muscle sprains, tears and damage may benefit from treatment with this peptide. You can download Peptologys free guide to peptide treatment therapies here.

Cerebrolysin | Also called FPE-1070. The neuroprotective properties of the nootropic peptide Cerebrolysin help to protect neurons from lactic acidosis and prevent the formation of free radicals. Cerebrolysin has been studied in memory loss, concentration decline, Parkinsons Disease, Alzheimers Disease, MS, TBI, and stroke.

CJC1295 | According to Functional Medicine Nurse Practitioner, Toni Tizon-Damiano this growth hormone peptide is one of the most popular peptides used at her practice.With growth hormone peptides, it is important to understand that were not injecting growth hormone itself. These peptides simply enhance the signaling to our pituitary to secrete more of our own supply of growth hormone.

The popular use of growth hormone peptides started after studies found that patients were injecting growth hormone and having negative outcomes. The use of peptides provided some of the benefits of enhancing our own natural supply of growth hormone without the negative side effects

Low growth hormone can cause an individual to feel fatigue, brain fog, depressed, mood changes, low libido, weaker muscle function or a decrease in the ability to gain muscle, an increase in fat and so much more.

Growth hormone is responsible for childhood development, but is also important in adulthood. Growth hormone is responsible for many functions in our body that we lose as we age. After age 30, there is a steady decline of growth hormone produced by our body. This decline is often due to aging but also to toxin exposure, oxidative stress, disease, lack of sleep, obesity, inflammation and of course, chronic stress.

DSIP or Delta sleep-inducing peptide | According to Dr. Jacey Folkers of Joi Womens Wellness, DSIP is a naturally occurring substance originally isolated from rabbit brains in 1977. DSIP has been described as a sleep-promoting substance rather than a sedative. Clinical uses for DSIP exist and the peptide has been used for the treatment of alcohol and opioid withdrawal with some success.

Semaglutide (Ozempic, Wegovy) | Semaglutide is a GLP-1 peptide (glucagon like peptide receptor agonist), says Nurse Practitioner, Toni Tizon-Damiano. Semaglutide has been prescribed for those with type 2 diabetes to help lower hemoglobin A1C (3 months blood sugar). These patients found that they were not only lowering their A1C, but also losing weight. Semaglutide helps to increase insulin secretion to decrease blood sugar in turn, decreasing appetite. Many of my clients are experiencing faster weight loss, lower cholesterol, lower hemoglobin A1C and potentially lowering their risk for cardiovascular related deaths.

Semaglutide was first developed in 2012 with 1 mg injection (Ozempic) first approved as a treatment for type 2 diabetes in 2017. The FDA approved semaglutide in 2021 for chronic weight management in adults with obesity or overweight with at least one weight-related condition (such as high blood pressure, type 2 diabetes, or high cholesterol).

Selank | This peptide has pronounced anxiolytic activity and acts as a stable neuropsychotropic, antidepressant, and anti-stress drug that relieves aggression and fear reaction in different animal species. Selank also has a nootropic action, which promotes the formation of memory and learning processes, and tremendous immunomodulatory activity.

Sermorelin is a peptide analogue of growth hormone-releasing hormone. It was first developed within the United States during the early 1980s. By 1997, the FDA approved its use and sale via prescription.

Yes, peptides have been around and researched much longer than most people realize. Sermorelin acts in a very specific way and is valued for its therapeutic possibilities. It does not affect the levels or actions of glucose, insulin, prolactin, cortisol, thyroid hormones and a host of other compounds within the body. Instead, sermorelin stimulates the body to increase its production of human growth hormone which improves the efficiency of the bodys metabolism. Because Sermorelin increases the bodys metabolism and improves energy levels, it has also been shown to have a beneficial effect on weight loss in people who want a more natural approach.

We also asked Dr. Jacey Folkers to weigh in further on the controversies surrounding semaglutide, from reduced access to diabetes meds, the narrative around weight loss culture even Ozempic face. He shared this with us:The latest data shows that over 73% of US adults are overweight or obese with obesity as the leading risk factor for type 2 diabetes. Whats more, cardiovascular disease remains the leading cause of death in America.

Both obesity and diabetes mellitus are important independent risk factors for the development of cardiovascular disease. We tend to categorize people based on official diagnoses, but just because a person struggling with weight or obesity has not been diagnosed as a diabetic does not necessarily mean they do not have the same health risk factors as a person who has. Medication that can help prevent and even reverse the chronic metabolic conditions that lead to diseases linked to diabetes and obesity should not necessarily be limited to one specific diagnosis.

Semaglutide can dramatically change the trajectory of a persons health by helping improve the metabolic and blood sugar imbalances many Americans have. For the most part, type 2 diabetes and obesity are conditions with significant lifestyle contributing factors. Semaglutide can help people make changes in their lifestyle that will benefit their health. It can help excess weight come off and blood sugar levels to improve, which can lead to overall better health.

When it comes to the discussion around Ozempic face, this side effect should not be blamed on the medication itself. When dosed appropriately, semaglutide can help facilitate a steady and gradual weight loss experience for many patients. With all medications, the dose is extremely important, as everyone responds to medications a bit differently. If a patient is being monitored well and dosed appropriately, their weight loss can be managed at a more gradual rate and prevent extremely fast drops in body mass, which can lead to Ozempic face.

Overall, peptides have far less side effects compared to pharmaceutical medications. Peptides have a pleiotropic effect (more than one effect) on the body and functions in the body in a more natural way. Medications often are meant to have a single direct effect and change or inhibit a naturally occurring pathway in the body. For example a COX2 inhibitor has a single targeted inhibition, and because of that, we get a whole bunch of side effects. The medication is forcing a response to occur in the body, whereas a peptide will moreso guide the bodys own built-in healing process to function better.

Tizon-Damiano notes that growth hormone peptides specifically are not safe for anyone that has a known cancer and have not been well studied in those with thyroid disorders. I require lab testing, vital signs, weight and BMI. Monitoring Insulin like growth factor (IGF-1) and other basic labs are crucial. IGF-1 is a biomarker that is the most important at mirroring what our growth hormone is doing. It has been studied in aging and the key is not to be too high or too low but to be balanced.

I urge people to commit to their peptide regimen for the full 6 months and then cycle off at least 30 days between to make sure that the body will continue to produce its own natural supply of growth hormone and wont develop resistance to it.

Tizon-Damianos patients most often see results in 3-6 months after daily injections that must be kept in the refrigerator. Side effects from peptide injections can include nausea and/or dizziness that commonly diminish once the body adjusts to the peptide.

The needles involved in peptide injections are very small, nonetheless most of them require injecting 5 out of 7 nights per week on an empty stomach.

Peptide injections usually range from $150-$300 per month depending on the peptide.

Read more from the original source:
6 Peptide Therapies According to Pros - What You Should Know - The Chalkboard Mag

Effective treatment of adult-onset growth hormone insufficiency: Sermorelin is an effective and attractive treatment of adult-onset GH insufficiency. Unlike rhGH, sermorelin does not stimulate IGF-1 production in the liver and instead stimulates the pituitary gland to produce and secrete endogenous hGH, giving it a number of clinical advantages over exogenous hGH.

Notably, according to a 2006 article by Richard Walker, overdoses of endogenous hGH are difficult if not impossible to achieve as the effects of sermorelin are regulated by negative feedback involving the inhibitory neurohormone, somatostatin.

Sermorelin is not associated with the pro-cancer and pro-diabetes side effects linked to long-term hGH therapy, and is thus heavily researched to treat adult-onset GH insufficiency along with being used in longevity medicine for preserving youthful anatomy and physiology [5].

Positive effects on body composition: Sermorelin has been identified as one of several growth hormone secretagogues (GHS) that can help manage body composition in hypogonadal males. In a 2020 paper, Deepankar et al. noted that sermorelin can significantly improve body composition (in hypogonadal males) while ameliorating specific hypogonadal symptoms such as fat gain and muscular atrophy [6].

While the authors suggest that sermorelin could be used to achieve lean mass gain in both hypogonadal males and men with subclinical hypogonadism, to date, there is no published research that has investigated sermorelins effect on body composition in healthy subjects, highlighting an area for further research.

Potential anti-aging benefits: A 1992 study identified sermorelins potential anti-aging benefits after nine young male test subjects (22 to 33 years old) and ten elderly male test subjects (60 to 78 years old) were administered the peptide. The study found that short-term subcutaneous sermorelin injections enabled healthy male test subjects to reverse age-related decreases in GH and levels of IGF-I [7].

A 1997 single-blind randomized placebo-controlled trial found that elderly male and female test subjects who received nightly subcutaneous injections of sermorelin for 16 weeks experienced a significant increase in skin thickness. The peptide was found to produce significant increases in lean body mass in male test subjects and notable increases in libido and wellbeing. Male test subjects gained an average of 1.26 kg of lean body mass by the end of the trial [8]

Sermorelin and heart health: Sermorelin has been investigated alongside other GHRH agonists as a potential treatment for myocardial infarction scarring in swine [9]. The 2015 study found that sermorelin offered a number of benefits in post-heart attack animal models, which included:

As a result, there is research interest in sermorelins heart health-related benefits, namely in its potential to treat problems resulting from cardiac remodeling and ability to heal damage in myocytes following a heart attack.

See the article here:
Sermorelin | Reviews, Dosage & Clinical Trials - Peptides

To properly grow and develop, your body needs human growth hormone (hGH). This is a peptide hormone produced in the tiny part of your brain called the pituitary gland. Although hGH plays its most crucial role during childhood and adolescence, it continues to maintain healthy tissues and organs throughout your life. Because of that, hGH levels that are lower or higher than typical can lead to health problems both in children and adults.

As often is the case with such complicated machines as our bodies, hGH does not act alone. A molecule called the growth hormone-releasing hormone (GHRH) controls hGH by releasing it from the pituitary gland into the bloodstream. If your blood test indicates low levels of hGH, your doctor may recommend injections of a synthetic form of GHRH, called sermorelin.

Keep reading to learn more about sermorelin, its benefits and risks, and when to consider using or avoiding sermorelin injections.

Sermorelin is used to diagnose and treat poor growth in children. Its also sometimes used off-label to treat hGH deficiency in adults. Some research has suggested that it can be beneficial in people with certain recurrent brain tumors.

Children usually benefit the most from sermorelin. One older study reported that a daily injection of sermorelin increased growth rate in 74 percent of children after just 6 months.

Studies investigating benefits of sermorelin in adults are scarce, but researchers have observed that sermorelin injection increases hGH levels in the bloodstream. These findings have led to widespread claims that sermorelin is an anti-aging therapy that can restore your bodys natural hGH production. Indeed, some older research suggests that sermorelin may increase:

However, definitive research to support the anti-aging effect of sermorelin is lacking. The use of sermorelin in healthy adults to reverse the effects of aging and in bodybuilding remains controversial.

Although long-term risks of sermorelin use are not known, its usually well-tolerated. However, as with any synthetic drug, its possible to have an allergic reaction. Let your doctor know about any allergies before taking this medication.

If you notice any of the following symptoms of a severe allergic reaction, call emergency medical services or go to the nearest emergency room:

The most common side effect of sermorelin is caused by its injection under your skin. You may experience any of the following at the site of injection:

These reactions are typically short-lived and disappear without any action. As you get better at self-administering the shots, these symptoms may stop for good.

Other, much less common side effects of sermorelin may include:

Sermorelin may interact with other medications. Drug interactions that may interfere with sermorelin include:

Make sure to let your doctor know about any medications and supplements you take (including vitamins) before starting sermorelin treatment.

Children and youths with poor growth are the primary candidates for sermorelin injections. In this group, sermorelin can help with both diagnosis and treatment of hGH deficiency.

Adults with diagnosed hGH deficiency can also benefit from sermorelin, according to older research. Healthy adults sometimes use this therapy for anti-aging and for bodybuilding; however this use remains controversial due to the scarcity of scientific evidence.

People with certain medical conditions may require additional screening before taking sermorelin and sometimes should avoid this therapy. These conditions include:

You dont need to visit a doctors office for sermorelin injections. Instead, you can self-administer injections at home. Sermorelin is injected subcutaneously, which means under the skin.

To prevent contamination, wipe the rubber vial stopper with an antiseptic before puncturing it with the needle. When injecting, target the fatty tissue just below the skin. Many people inject their stomach or thigh. To avoid bruising and soreness, its best to switch up the location of the injection site. Ask your doctor to show you the best injection technique.

Sermorelin is administered once a day, ideally at night. Your doctor will determine your dosage and length of treatment based on your individual factors.

You may be wondering: If the purpose of sermorelin therapy is to increase the levels of hGH hormone, why cant you just inject hGH? The answer is that many people do. In fact, research suggests that genetically engineered hGH is an effective treatment for both poor growth in children and hGH deficiency in adults. Unfortunately, hGH therapy is associated with numerous risks and side effects. Therefore, it may not be appropriate for some people.

Sermorelin helps your body produce more hGH. Children with growth delays and adults with hGH deficiency may benefit from this therapy. Although some healthy adults take it to prevent aging and for bodybuilding, there is no definitive research suggesting that sermorelin is effective for either of these purposes.

Although this medication is usually well-tolerated, tell your doctor about any allergies and medical conditions you have as well as medications and supplements you take. Check in regularly with your doctor while youre taking it.

See the article here:
Sermorelin Therapy Benefits, Uses, Side Effects, Risks, More

Sermorelin vs Ipamorelin

Sermorelin and ipamorelin peptides are very similar in many ways. Despite their similarities, however, these two peptides are different enough that their applications can be tailored for specific needs. Both peptides stimulate the natural secretion of growth hormone, but they do so via different receptors. As a result of their effects on growth hormone (GH) levels, Ipamorelin and Sermorelin both cause increased fat burning and muscle building, enhanced long bone growth, decreased inflammation, and improved wound healing. However, their actions via different receptors result in these two peptides having slightly different ancillary effects.

Sermorelin vs Ipamorelin: Receptor Science

Sermorelin is an analogue of growth hormone-releasing hormone (GHRH) and binds to the GHRH receptor (GHRH-R). Ipamorelin, however, is a ghrelin analogue and binds primarily to the growth hormone secretagogue receptor (GHS-R). While both peptides can be referred to under the umbrella category of growth hormone releasing peptides, their different receptor binding preferences mean they have different effects on GH levels.

At baseline, Sermorelin potentiates GH release and helps to extend GH highs. It is best thought of as extending GH peaks and prolonging the amount of time that GH levels are elevated while preserving the normal ebb and flow (pulsatile secretion) of GH throughout that day. Ipamorelin, on the other hand, is better thought of as dramatically raising GH levels, sometimes by as much as 13 times above baseline levels. Ipamorelin has dramatic, but short-lived effects on GH levels.

Sermorelin and Growth Hormone Potentiation

The GHRH-R is the primary receptor on the anterior pituitary gland for controlling growth hormone release. When stimulated, it causes the release of growth hormone. Research shows that Sermorelin binding to the GHRH-R is effective at concentrations as low as 0.4x10-15M[1]. This makes Sermorelin an extremely potent GHRH agonist and approximately 50 times more potent than naturally occurring GHRH. This is the reason that it was originally referred to as a super-active analogue of growth hormone releasing hormone[2].

Interestingly, Sermorelin tends to not cause massive increases in GH levels when it is administered. It does, however, augment the duration of GH release. That is to say, while Sermorelin definitely increases GH levels, its primary effect is to extend the duration of GH release, helping to maintain peak levels for longer periods of time[3]. By extending the release of GH, Sermorelin does, in fact, raise GH levels but it also smooths out the peaks of GH release and widens them a bit. This does not, however, obliterate the normal pulsatile secretion of GH, which is important for minimizing side effects. In fact, Sermorelins biggest benefit is the fact that it preservers the normal physiologic pattern of GH release, thus mitigating side effects like swelling, joint pain, and excessive long bone growth[4].

Ipamorelin and Growth Hormone Peaks

Ipamorelin (as well as ghrelin) is an amplifier of GH pulsatility and is speculated to play a role in creating a set point for insulin-like growth factor 1 levels[5]. Research has shown that subcutaneous administration of Ipamorelin causes an intense spike in growth hormone levels just 5-15 minutes after injection followed by a relatively rapid decline. Thus, ipamorelin does not really potentiate GH secretion like Sermorelin does. Instead, ipamorelin is better thought of as boosting maximum levels of growth hormone output for a very short duration of time. Depending on when and how ipamorelin is administered, this could mean augmenting peak GH levels or raising trough levels. Thus, timing of ipamorelin administration can, to some extent, affect the peptides effects.

Ipamorelin, at its ED50 (50% of the maximum effective dose), causes plasma GH levels to increase to approximately 65 ng/mL in animal models. Normally, growth hormone levels in men are below 5 ng/mL while in women they are below 10 ng/mL. This means Ipamorelin administration raises GH levels by anywhere from 6.5 to 13 times the maximum level. In children, growth hormone levels range from 0-20 ng/mL based on age. Ipamorelin has a short half-life of two hours. When administered, it causes maximum GH release after about 40 minutes followed by an exponential decline[6].

This rapid on, rapid off property of Ipamorelin is a holdover from its natural counterpart, ghrelin. Recall that ghrelin and Ipamorelin can both stimulate appetite. This occurs via binding to the GHS-R and subsequent release of neuropeptide Y. Given that it takes time to eat and digest food, it makes sense that ipamorelin would have its maximum effects approximately 40 minutes after injection (or release in the case of ghrelin). This gives the peptide its best chance of making using of nutrients for building muscle, bone, connections between neurons, and more.

Sermorelin vs Ipamorelin: Structure and Route of Administration

Sermorelin is made up of the first 29 amino acids from the much larger, naturally occurring GHRH peptide. It is the smallest fraction of GHRH than retains all of the properties of the parent molecule. Weighing in at 3357.9 g/mol, Sermorelin is a relatively large, heavy peptide that must be injected sub-cutaneous to be absorbed. It is not orally bioavailable. As a result of its large size, Sermorelin has a more significant three-dimensional structure than Ipamorelin and is thus is a little less stable in terms of storage half-life.

Source: PubChem

Ipamorelin is substantially smaller than Sermorelin at just5 amino acids and 711.868 g/mol. It is a derivative of GHRP-1, which is itselfa derivative of met-enkephalin. Though the most common route of administrationfor Ipamorelin is via sub-cutaneous injection, the peptide is also orallyactive and can even be absorbed though the nasal mucosa.

Source: PubChem

Ipamorelin vs Sermorelin: Lean Body Mass

Both Sermorelin and Ipamorelin favor the development of lean body mass over fat mass, but Sermorelin is the more potent of the two. This arises from the fact that Sermorelin is both a growth stimulator and a fat burner while Ipamorelin is a more general growth stimulator. That is not to say that Ipamorelin isnt effective, it is, but ipamorelin isnt as strictly favorable of lean body mass deposition as Sermorelin. This difference arises from the fact that Ipamorelin is a ghrelin analogue and ghrelin favors food intake in general. Its growth hormone boosting properties shift the overall balance away from fat deposition and toward lean body mass deposition, but the Ipamorelin peptide is best thought of as a general weight boosting peptide while Sermorelin is best thought of as a more exclusive booster of lean body mass. In fact, Sermorelin is often referred to as a lipolytic or fat-burning peptide.

Both peptides stimulate the development of bone and other connective tissue, but Ipamorelin appears to have the advantage in this realm. In fact, ipamorelin is so effective in boosting bone density and mineralization that it has been investigated as a potential treatment for corticosteroid-induced bone loss as well as osteoporosis[7], [8].

When it comes to muscle growth, Sermorelin is probably the big winner, though this can be debated endlessly. Sermorelin not only boosts muscle hypertrophy and hyperplasia, it reduces fat mass and thus causes a shift in body chemistry toward lean body weight. In other words, Sermorelin will always favor the production of lean body mass even if diet is not perfectly geared toward muscle development. Ipamorelin, on the other hand, is more of a mixed bag. It will always cause muscle growth, but ipamorelin may channel some of those calories into fat deposition as well.

Ipamorelin vs Sermorelin: Anti-Aging Properties

Both Ipamorelin and Sermorelin, via their GH releasing potential, have potent anti-aging properties. Sermorelin, however, is the clear front runner in this particular face off. Sermorelin has been shown to improve joint function, skin thickness, skin collagen structure, wound healing, cardiac fibrosis, strength, and metabolism. According to Dr. Richard Walker, Ph.D., of the International Society for Advanced Research in Aging, Sermorelin helps to preserve more of the growth hormone axis than most other GHRH analogues, resulting in a more youthful hormone profile. In other words, if you took profiles of GH biochemistry throughout an individuals lifetime, you would find that Sermorelin tends to dial back that chemistry to a more youthful setting.

Ipamorelin as Pain Reliever

One of the biggest differences between Ipamorelin and Sermorelin lies in the fact that Ipamorelin triggers the release of neuropeptide Y. This peptide is an important neurotransmitter in the control of appetite and food preference, but it also plays an important role in how we perceive pain. In fact, the connection between food and good feelings is likely due, in part, to the effects of neuropeptide Y.

Research in rats indicates that Ipamorelin may help to reduce pain perception by has much as 2-fold. This is particularly true of visceral pain, which is to say stomach pain. Visceral pain is difficult to treat, so ipamorelin offers a potential starting point for understanding how to better control the pain associated with conditions like irritable bowel syndrome, Crohns disease, ulcerative colitis, and more. There are also potential applications in neuropathic pain syndromes like diabetic neuropathy and degenerative disk disease[9].

Sermorelin and Sleep

Research in rats shows that Sermorelin is an effective regulator of the sleep cycle. Sleep and aging go hand int hand, with one affecting the other such that older people often have less adequate less restful sleep. Sermorelin appears to achieve its sleep benefits by regulating orexin release from specialized neurons in the brain. Orexin is an important neurotransmitter in sleep regulation and Sermorelin appears to boost orexin secretion. This leads to an increase in non-REM slow-wave sleep, which is associated with more restful sleep, improved immune function, better wound healing, and happier mood[10], [11]. Its effects on sleep may be one of the reasons that Sermorelin is a potent anti-aging peptide.

Sermorelin vs Ipamorelin: Summary

Sermorelin peptides and Ipamorelin peptides are more similar than they are different, but that doesnt mean there arent distinctions between these two growth-promoting peptides. Practically speaking, Sermorelin is the all-around peptide. It promotes lean body mass gains, boosts fat burning, and fights the effects of aging. It is also a more holistic simulator of the GH axis and, as such, helps the body to maintain youth-like patterns of GH secretion.

Ipamorelin is the more potent of the two peptides. Its effects are large, but relatively short-lived. Ipamorelin is a gainer peptide. It builds lean body mass, but also builds overall body mass. It is a potent stimulator of bone growth and has some pain fighting properties as well.

There has been some research investigating the effects of combining Sermorelin and Ipamorelin. Because these peptides affect two different receptors, their actions when combined tend to be synergistic. Unfortunately, the research in this area is limited, so there isnt a great deal of data on how the combination of these two peptides can help to improve appetite, alter body composition, fight off cardiovascular disease, slow the progression of aging, and promote general good health. In the end, both Ipamorelin and Sermorelin have been studied extensively, but individually, for their significant impacts on GH. Both peptides are effective, but have slightly different ancillary effects that have driven researchers in different directions as they explore potential applications for ipamorelin peptides and sermorelin peptides.

Resources

[1] M. L. Heiman, M. V. Nekola, W. A. Murphy, V. A. Lance, and D. H. Coy, An extremely sensitive in vitro model for elucidating structure-activity relationships of growth hormone-releasing factor analogs, Endocrinology, vol. 116, no. 1, pp. 410415, Jan. 1985, doi: 10.1210/endo-116-1-410.

[2] V. A. Lance, W. A. Murphy, J. Sueiras-Diaz, and D. H. Coy, Super-active analogs of growth hormone-releasing factor (1-29)-amide, Biochem. Biophys. Res. Commun., vol. 119, no. 1, pp. 265272, Feb. 1984, doi: 10.1016/0006-291x(84)91647-4.

[3] A. Grossman et al., Responses to analogues of growth hormone-releasing hormone in normal subjects, and in growth-hormone deficient children and young adults, Clin. Endocrinol. (Oxf.), vol. 21, no. 3, pp. 321330, Sep. 1984, doi: 10.1111/j.1365-2265.1984.tb03477.x.

[4] R. F. Walker, Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?, Clin. Interv. Aging, vol. 1, no. 4, pp. 307308, 2006, doi: 10.2147/ciia.2006.1.4.307.

[5] Y. Sun, P. Wang, H. Zheng, and R. G. Smith, Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor, Proc. Natl. Acad. Sci. U. S. A., vol. 101, no. 13, pp. 46794684, Mar. 2004, doi: 10.1073/pnas.0305930101.

[6] J. V. Gobburu, H. Agers, W. J. Jusko, and L. Ynddal, Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers, Pharm. Res., vol. 16, no. 9, pp. 14121416, Sep. 1999, doi: 10.1023/a:1018955126402.

[7] N. B. Andersen, K. Malmlf, P. B. Johansen, T. T. Andreassen, G. rtoft, and H. Oxlund, The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats, Growth Horm. IGF Res., vol. 11, no. 5, pp. 266272, Oct. 2001, doi: 10.1054/ghir.2001.0239.

[8] J. Svensson et al., The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats, J. Endocrinol., vol. 165, pp. 56977, Jul. 2000.

[9] E. N Mohammadi, T. Louwies, C. Pietra, S. R. Northrup, and B. Greenwood-Van Meerveld, Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics, J. Exp. Pharmacol., vol. 12, pp. 267274, 2020, doi: 10.2147/JEP.S249747.

[10] B. S. Shepherd et al., Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout (Oncorhynchus mykiss), Comp. Biochem. Physiol. A. Mol. Integr. Physiol., vol. 146, no. 3, pp. 390399, Mar. 2007, doi: 10.1016/j.cbpa.2006.11.004.

[11] A Good Nights Sleep, National Institute on Aging. http://www.nia.nih.gov/health/good-nights-sleep (accessed Nov. 22, 2020).

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Sermorelin vs Ipamorelin: Best Guide in 2022 - PeptideSciences.com

As the economy improves, more and more people start their businesses. This can be a daunting task for someone who has never worked on a team before. When people work without much experience working in groups, they often become overwhelmed by the task and quit before finishing anything. To ensure that your team can make it through business-building, its essential to learn how to keep yourself organized and focused while building chemistry with other people.

Tips for building professionals from beginners

One thing that scares people about hiring newbies is losing their productivity. It can be avoided by involving them in your new process. A simple example would be sending out a reminder email or making sure they know project deadlines and goals. Still, you can also involve them in product concept development and design, giving them input on features they like.

The key to productivity is not talking but, instead, doing. If you have a more talented person on your team and arent willing to help, you already know you cant get production out of them. It would help if you showed them that by communicating with the team regularly and showing them the results of the work they have produced. It can be as simple as commenting on their previous work or as complex as giving a feedback session after each project.

One of the things that can make an incompetent person productive is the feeling of pride that comes from knowing theyre helping others. Make your team members feel proud when they help you with problems, or show off this by making it a point to thank them for their hard work on one of their projects. Doing this will encourage your employees to put in more effort and provide better quality outputs. This also works well for teams, who may feel more motivated by service offers than money.

Rewarding your employees is something you probably do with friends or family, but it can work wonders for a team. Since incentives are purely based on motivation, this is a great way to keep a team of people working hard and motivated to come back every morning. Giving them bonuses and praise as they work can make your team more productive and more money!

One of the things that can hurt productivity is bossiness. This doesnt work for many people as it can cause them to lose interest and motivation. Try to be a benevolent dictator and give them clear goals and strategies. This way, you can get their best output without putting unnecessary pressure on them.

The biggest mistake we make in todays market is working against each other instead of working together on the same project. Many reasons can cause this breakdown, but the main problem is that we are working for high stakes. Instead, your employees should be aware that they are committed to their job and that you have a commitment to them. This will make them think twice before going to work without showing up and doing whats needed.

How to motivate your team

Let your team go to work at their own pace, and dont get in their way unless youre asking for help. If you do it this way, they are more likely to deliver whats promised and get the best out of themselves.

Show your employees that you respect them by talking to them and how you treat them. Please dont get too personal with your employees, and dont talk down to them like children. If they release lousy work, dont yell at them; instead, help them improve or give specific directions on how to do it better. Respect builds loyalty which is just another thing that makes for a more productive team!

This is one of the most important things you can do to motivate your team and let them know that you appreciate their hard work. Feedback is a form of recognition, and its also important because it allows them to learn and improve. You can give feedback by sharing their work with the rest of the team, or you can give them points on their performance so that if they dont meet expectations next time, theyll be able to improve.

When employees are not motivated and are not having fun at work, they stop showing up and get less productive. This can be fixed by ensuring that they like their job and are happy and enjoying their work, but its also essential to give them a break. Have fun!

Causes of poor performance

This is one of the leading causes of poor performance at work because it keeps you from being able to concentrate on your tasks and causes nausea, dizziness, flu-like symptoms, and loss of appetite. The other reason this causes poor performance is that it makes you sick and tired, which will cause you to have more health issues at work. Considering Sermorelin therapy, first make sure your blood work proves your HGHD.

This is the most common cause of poor performance that you can find on the internet. People who work long hours are more likely to get sick and dont take good care of themselves, which causes them to have a lot of health issues at work.

This is one of the biggest reasons for poor performance, and it is something that many people dont think about until they have a severe illness or injury. Depression is a disease that keeps a person from being able to concentrate or focus on their job. This can be caused by many things, like a broken relationship or losing a close family member. The best thing you can do for your team is to make sure they are supported and happy.

When your employees are happy, they will be more productive, but they will want to help you out and do what you need. All these things combined make for a better team of happy and healthy people. This can be achieved by giving your employees the proper training and motivation and letting them take breaks and go home early when they need to get rest.

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Tips for Business: How to Create a Team of Professionals From Beginners - The Roanoke Star

Skin Envy owner Stephanie Davison often makes many 90 Day Fianc fans envious of her youthful looks. The TLC star, 52, has now confessed her secrets.

Although Stephanie Davidson from 90 Day Fianc is making waves for her relationship with her Belize boy toy Ryan Carr, it's also her looks that have fans saying "wow." Sure, being the face of a business that makes one "remove fat" helps, but what is that keeps Stephanie looking so good at 52? The 90 Day Fianc star Stephanie has revealed what is her fountain of youth on her Instagram page.

As fans try to decipher why a successful, independent woman like 90 Day Fianc's Stephanie could choose to date someone like Ryan, they also have started guessing the relationship won't last long. With Stephanie mentioning that Ryan had been talking to other women in spite of her paying for his bills for three years, the possibility of her choosing his cousin Harris might become a reality. A traumatic childhood and then loveless adulthood is what Stephanie finally left behind when she decided to couple up with Ryan. But a recent episode saw the 90 Day Fianc star shocking her friends with the revelation that she pays for Ryan's salary too. Of course, her sleeping with Ryans cousin could have made her guilty enough to pay his bills but TLC viewers couldnt help wondering if Stephanie was getting played. After all, a Maserati-driving, successful boss woman who looks way younger than her years could date anyone, right? Especially if the self-proclaimed sugar mama whose Instagram comments are filled with 90 Day Fianc fans asking Stephanie for her secret to looking half her age.

Related:90 Day Fianc: Throwback Video Shows Stephanie Selling Sermorelin Injection

Not surprisingly, 90 Day Fiancs Stephanie has been a fan-favorite since season 8s premiere even though she appeared on the reality show weeks later. Fans were curious about this cat-lady who was calling herself a cougar and Ryan her cub as she sent him expensive watches in the trailer. The Grand Rapids lady soon gained more interest by hosting expensive giveaways for handbags on her Instagram, which some 90 Day Fianc couldnt help but love her for. However, it was Stephanies weigh-loss spa Skin Envy that made her much more interesting. As expected, the 90 Day Fianc stars age-defying routine owes a lot to her own business.

When asked by an IG follower, How can I look like you? 90 Day Fiancs Stephanie replied, Well, the Youth Serum Sermorelin/Ipamorelin shots are $4500 a year. But Stephanie also gave an alternative option by suggesting, dont drink much alcohol, get at least 8 hours of sleep at night. Ryans Michigan lover also revealed that she drinks at least 8 glasses of PURIFIED water daily. And for exercise, 90 Day Fiancs Stephanies go-to is a hula hoop.

The curious TLC viewer further enquired Stephanie about her injections as she wrote, can I buy them from your store, and can you ship them? And the marketing maverick that she is, 90 Day Fianc star Stephanie shared, Call my medical assistant Pam. Spoilers suggest that Stephanie will be dumping Ryan while in Belize next and coming back to America with cousin Harris. But while that may take a while to happen on 90 Day Fianc, one things for sure, Stephanie is surely going to get a lot of calls at Skin Envy, all due to the fans who are in awe, if not envious of her own beauty.

Next:90 Day Fianc: Shocking Details Of Jovi Dufren's Criminal Past Revealed

90 Day Fianc airs Sundays at 8pm EST on TLC.

Source: Stephanie Davison/Instagram

90 Day Fianc: Yazan's Fans Turn Into Haters After Seeing His New IG Pic

Saylee Padwal is a Reality TV Features Writer for Screen Rant. When she's not thinking about pop-culture or food, you can always find her "investigating" her way through Instagram, reading mysteries and thrillers, and listening to BTS on loop.

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90 Day Fianc: Stephanie Davison Reveals The Secrets To Her Youthful Looks - Screen Rant

'90 Day Fiance' stars Stephanie Davison and Ryan Carr's relationship never really took off. It's been a little over a month since Season 8 of the show has premiered but there's been no progress on that front. The couple is yet to share their stories fully on television.

However, in this week's episode, we learned more about Stephanie and the kind of work she does for a living that kept her from focussing on love and marriage so far. Here's all we know about the Skin Envy place where she works. If you're wondering if that's the secret to her drop-dead gorgeous look, here's the truth.

She is an entrepreneur and operates two medical spas out of Michigan. Skin Envy was designed for clients looking at easy age reversal and weight loss options. Stephanie has been making good sales out of her two outlets and what seems to have worked for her is trying some of these shot serums on herself. She injects herself with Sermorelin, which apparently wakes up her pituitary gland and that helps restore youth.

Her clinics also offer HGC injections for those wanting to shed a few extra kilos. The shots "stimulate the bodys natural ability to produce HGH leading to renewed energy, sex drive, lowered body fat and so much more," her website writes. Woah!

This aside, the spas also have mesotherapy, hydra facial, infrared sauna, and more on the roster. But how effective are these treatments? The testimonials on the Skin Envy site is proof enough. "My love handles would not go away no matter how much I would diet or exercise. Mesotherapy has helped me to get a more shapely waist!," Jan M reviewed the treatments.

Also, Stephanie had two of her cousins, Shannon and Ryanne, visit her on the show. Apparently, Shannon lost 80 pounds by Skin Envy's methods and so Ryanne wanted to test it out and see if she can achieve similar results and it clearly worked for her!

Although her '90 Day Fiance' paycheck is not known, her estimated net worth from all the successful businesses she owns is at $1.5 million, Starsoffline reported.

Catch all the new episodes of '90 Day Fiance' on TLC every Sunday at 8/7c. For more information, check your local listings.

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'90 Day Fiance': What is Stephanie Davison's job and net worth? Truth behind 80 pounds weight loss from inject - MEAWW

As we head into our 40s and 50s, things begin to change really change. By the time we reach our 60s, we question why everything seems to have gone south. The reason why your body feels and looks different is that it is different. Our bodies stop producing the human growth hormones they produced when we were younger. Thankfully, sermorelin can replenish insufficient HGH levels. Revive Medical Center uses this treatment to help their patients rebuild and repair damaged and weakened cells.

Although it takes a few months of treatments to really experience the benefits of sermorelin, many of our patients feel that the benefits are worth the wait. The results of sermorelin therapy include

This might sound too good to be true but when you think about how sermorelin works, it makes perfect sense. Sermorelin encourages your pituitary gland to produce HGH, the hormone it produced when you were younger. It helps your body restore the hormone levels lost during the aging process.

This anti-aging treatment comes with minimal side effects, which also makes it appealing to patients. Sermorelin is administered through an injection, and some patients report discomfort at the injection site. There might be some minor pain, redness, and/or swelling. On rare occasions, a handful of patients have also reported itching and difficulty swallowing, suggesting an allergy to the treatment.

Other rare side effects include dizziness, flushed skin, headaches, insomnia, and restlessness. These side effects are uncommon, and wed be happy to discuss any concerns you might have about the sermorelin treatment before you begin the program. In most cases, sermorelin is a more effective anti-aging treatment with fewer side effects than other HGH replacement therapies.

If you are interested in learning more about sermorelin anti-aging treatments, call Revive Medical Center at 678-701-6397.

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What Are the Benefits and Side Effects of Sermorelin ...

In total, there are 20 different amino acids. They all have vastly different properties and exert different effects within the system.

Whilst a protein may contain 50 or more amino acids, the balance of the amino acids it contains ultimately determines what kind of impact it will have on the body.

The same goes for peptides too; amino acids can lead to everything from CNS (Central Nervous System) responses to the replenishment and evolution of organ tissue and muscle cells.

We can only synthesise 11 of these 20 amino acids on our own using our internal mechanisms; we need to source the other 9 (known as essential amino acids because they are essential components of our nutritional intake) from food meaning that the spectrum of benefits on offer by the proteins and peptides we naturally produce are somewhat resigned to the effects on offer with these 11 acid types only.

Bioengineering allows us to combine these 11 man made amino acids with any number of the other 9 essential amino acids to produce compounds that are capable of exerting varying effects on the body.

Not only that, but we can actually choose to alter the structure of either essential or nonessential amino acids, further manipulating the effects they can exert.

Regardless of the manner in which a peptide or protein is created (either naturally occurring or unnaturally synthesises in a laboratory) the crux of the entire operational efforts of these molecules is indeed the amino acid code contained within.

As previously stated, these individual acids can lead to any one of several responses within the body combining them together can exert either multiple or one primary effect.

Its still not entirely known how certain amino acid sequences can lead to certain effects occurring.

Being that amino acids are considered to be the building blocks of the human body, it is perhaps possible that each and every hormone / enzyme contains its own unique amino acid code, and once discovered, the effects of said hormone or enzyme can be recreated / replicated.

That certainly appears to be the case in this instance, because the 29 amino acid code contained within sermorelin directly mimics the effects of growth hormone releasing hormone.

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