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Jul 8

Sermorelin Therapy Benefits, Uses, Side Effects, Risks, More

To properly grow and develop, your body needs human growth hormone (hGH). This is a peptide hormone produced in the tiny part of your brain called the pituitary gland. Although hGH plays its most crucial role during childhood and adolescence, it continues to maintain healthy tissues and organs throughout your life. Because of that, hGH levels that are lower or higher than typical can lead to health problems both in children and adults.

As often is the case with such complicated machines as our bodies, hGH does not act alone. A molecule called the growth hormone-releasing hormone (GHRH) controls hGH by releasing it from the pituitary gland into the bloodstream. If your blood test indicates low levels of hGH, your doctor may recommend injections of a synthetic form of GHRH, called sermorelin.

Keep reading to learn more about sermorelin, its benefits and risks, and when to consider using or avoiding sermorelin injections.

Sermorelin is used to diagnose and treat poor growth in children. Its also sometimes used off-label to treat hGH deficiency in adults. Some research has suggested that it can be beneficial in people with certain recurrent brain tumors.

Children usually benefit the most from sermorelin. One older study reported that a daily injection of sermorelin increased growth rate in 74 percent of children after just 6 months.

Studies investigating benefits of sermorelin in adults are scarce, but researchers have observed that sermorelin injection increases hGH levels in the bloodstream. These findings have led to widespread claims that sermorelin is an anti-aging therapy that can restore your bodys natural hGH production. Indeed, some older research suggests that sermorelin may increase:

However, definitive research to support the anti-aging effect of sermorelin is lacking. The use of sermorelin in healthy adults to reverse the effects of aging and in bodybuilding remains controversial.

Although long-term risks of sermorelin use are not known, its usually well-tolerated. However, as with any synthetic drug, its possible to have an allergic reaction. Let your doctor know about any allergies before taking this medication.

If you notice any of the following symptoms of a severe allergic reaction, call emergency medical services or go to the nearest emergency room:

The most common side effect of sermorelin is caused by its injection under your skin. You may experience any of the following at the site of injection:

These reactions are typically short-lived and disappear without any action. As you get better at self-administering the shots, these symptoms may stop for good.

Other, much less common side effects of sermorelin may include:

Sermorelin may interact with other medications. Drug interactions that may interfere with sermorelin include:

Make sure to let your doctor know about any medications and supplements you take (including vitamins) before starting sermorelin treatment.

Children and youths with poor growth are the primary candidates for sermorelin injections. In this group, sermorelin can help with both diagnosis and treatment of hGH deficiency.

Adults with diagnosed hGH deficiency can also benefit from sermorelin, according to older research. Healthy adults sometimes use this therapy for anti-aging and for bodybuilding; however this use remains controversial due to the scarcity of scientific evidence.

People with certain medical conditions may require additional screening before taking sermorelin and sometimes should avoid this therapy. These conditions include:

You dont need to visit a doctors office for sermorelin injections. Instead, you can self-administer injections at home. Sermorelin is injected subcutaneously, which means under the skin.

To prevent contamination, wipe the rubber vial stopper with an antiseptic before puncturing it with the needle. When injecting, target the fatty tissue just below the skin. Many people inject their stomach or thigh. To avoid bruising and soreness, its best to switch up the location of the injection site. Ask your doctor to show you the best injection technique.

Sermorelin is administered once a day, ideally at night. Your doctor will determine your dosage and length of treatment based on your individual factors.

You may be wondering: If the purpose of sermorelin therapy is to increase the levels of hGH hormone, why cant you just inject hGH? The answer is that many people do. In fact, research suggests that genetically engineered hGH is an effective treatment for both poor growth in children and hGH deficiency in adults. Unfortunately, hGH therapy is associated with numerous risks and side effects. Therefore, it may not be appropriate for some people.

Sermorelin helps your body produce more hGH. Children with growth delays and adults with hGH deficiency may benefit from this therapy. Although some healthy adults take it to prevent aging and for bodybuilding, there is no definitive research suggesting that sermorelin is effective for either of these purposes.

Although this medication is usually well-tolerated, tell your doctor about any allergies and medical conditions you have as well as medications and supplements you take. Check in regularly with your doctor while youre taking it.

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Sermorelin Therapy Benefits, Uses, Side Effects, Risks, More


Jul 8

Sermorelin vs Ipamorelin: Best Guide in 2022 – PeptideSciences.com

Sermorelin vs Ipamorelin

Sermorelin and ipamorelin peptides are very similar in many ways. Despite their similarities, however, these two peptides are different enough that their applications can be tailored for specific needs. Both peptides stimulate the natural secretion of growth hormone, but they do so via different receptors. As a result of their effects on growth hormone (GH) levels, Ipamorelin and Sermorelin both cause increased fat burning and muscle building, enhanced long bone growth, decreased inflammation, and improved wound healing. However, their actions via different receptors result in these two peptides having slightly different ancillary effects.

Sermorelin vs Ipamorelin: Receptor Science

Sermorelin is an analogue of growth hormone-releasing hormone (GHRH) and binds to the GHRH receptor (GHRH-R). Ipamorelin, however, is a ghrelin analogue and binds primarily to the growth hormone secretagogue receptor (GHS-R). While both peptides can be referred to under the umbrella category of growth hormone releasing peptides, their different receptor binding preferences mean they have different effects on GH levels.

At baseline, Sermorelin potentiates GH release and helps to extend GH highs. It is best thought of as extending GH peaks and prolonging the amount of time that GH levels are elevated while preserving the normal ebb and flow (pulsatile secretion) of GH throughout that day. Ipamorelin, on the other hand, is better thought of as dramatically raising GH levels, sometimes by as much as 13 times above baseline levels. Ipamorelin has dramatic, but short-lived effects on GH levels.

Sermorelin and Growth Hormone Potentiation

The GHRH-R is the primary receptor on the anterior pituitary gland for controlling growth hormone release. When stimulated, it causes the release of growth hormone. Research shows that Sermorelin binding to the GHRH-R is effective at concentrations as low as 0.4x10-15M[1]. This makes Sermorelin an extremely potent GHRH agonist and approximately 50 times more potent than naturally occurring GHRH. This is the reason that it was originally referred to as a super-active analogue of growth hormone releasing hormone[2].

Interestingly, Sermorelin tends to not cause massive increases in GH levels when it is administered. It does, however, augment the duration of GH release. That is to say, while Sermorelin definitely increases GH levels, its primary effect is to extend the duration of GH release, helping to maintain peak levels for longer periods of time[3]. By extending the release of GH, Sermorelin does, in fact, raise GH levels but it also smooths out the peaks of GH release and widens them a bit. This does not, however, obliterate the normal pulsatile secretion of GH, which is important for minimizing side effects. In fact, Sermorelins biggest benefit is the fact that it preservers the normal physiologic pattern of GH release, thus mitigating side effects like swelling, joint pain, and excessive long bone growth[4].

Ipamorelin and Growth Hormone Peaks

Ipamorelin (as well as ghrelin) is an amplifier of GH pulsatility and is speculated to play a role in creating a set point for insulin-like growth factor 1 levels[5]. Research has shown that subcutaneous administration of Ipamorelin causes an intense spike in growth hormone levels just 5-15 minutes after injection followed by a relatively rapid decline. Thus, ipamorelin does not really potentiate GH secretion like Sermorelin does. Instead, ipamorelin is better thought of as boosting maximum levels of growth hormone output for a very short duration of time. Depending on when and how ipamorelin is administered, this could mean augmenting peak GH levels or raising trough levels. Thus, timing of ipamorelin administration can, to some extent, affect the peptides effects.

Ipamorelin, at its ED50 (50% of the maximum effective dose), causes plasma GH levels to increase to approximately 65 ng/mL in animal models. Normally, growth hormone levels in men are below 5 ng/mL while in women they are below 10 ng/mL. This means Ipamorelin administration raises GH levels by anywhere from 6.5 to 13 times the maximum level. In children, growth hormone levels range from 0-20 ng/mL based on age. Ipamorelin has a short half-life of two hours. When administered, it causes maximum GH release after about 40 minutes followed by an exponential decline[6].

This rapid on, rapid off property of Ipamorelin is a holdover from its natural counterpart, ghrelin. Recall that ghrelin and Ipamorelin can both stimulate appetite. This occurs via binding to the GHS-R and subsequent release of neuropeptide Y. Given that it takes time to eat and digest food, it makes sense that ipamorelin would have its maximum effects approximately 40 minutes after injection (or release in the case of ghrelin). This gives the peptide its best chance of making using of nutrients for building muscle, bone, connections between neurons, and more.

Sermorelin vs Ipamorelin: Structure and Route of Administration

Sermorelin is made up of the first 29 amino acids from the much larger, naturally occurring GHRH peptide. It is the smallest fraction of GHRH than retains all of the properties of the parent molecule. Weighing in at 3357.9 g/mol, Sermorelin is a relatively large, heavy peptide that must be injected sub-cutaneous to be absorbed. It is not orally bioavailable. As a result of its large size, Sermorelin has a more significant three-dimensional structure than Ipamorelin and is thus is a little less stable in terms of storage half-life.

Source: PubChem

Ipamorelin is substantially smaller than Sermorelin at just5 amino acids and 711.868 g/mol. It is a derivative of GHRP-1, which is itselfa derivative of met-enkephalin. Though the most common route of administrationfor Ipamorelin is via sub-cutaneous injection, the peptide is also orallyactive and can even be absorbed though the nasal mucosa.

Source: PubChem

Ipamorelin vs Sermorelin: Lean Body Mass

Both Sermorelin and Ipamorelin favor the development of lean body mass over fat mass, but Sermorelin is the more potent of the two. This arises from the fact that Sermorelin is both a growth stimulator and a fat burner while Ipamorelin is a more general growth stimulator. That is not to say that Ipamorelin isnt effective, it is, but ipamorelin isnt as strictly favorable of lean body mass deposition as Sermorelin. This difference arises from the fact that Ipamorelin is a ghrelin analogue and ghrelin favors food intake in general. Its growth hormone boosting properties shift the overall balance away from fat deposition and toward lean body mass deposition, but the Ipamorelin peptide is best thought of as a general weight boosting peptide while Sermorelin is best thought of as a more exclusive booster of lean body mass. In fact, Sermorelin is often referred to as a lipolytic or fat-burning peptide.

Both peptides stimulate the development of bone and other connective tissue, but Ipamorelin appears to have the advantage in this realm. In fact, ipamorelin is so effective in boosting bone density and mineralization that it has been investigated as a potential treatment for corticosteroid-induced bone loss as well as osteoporosis[7], [8].

When it comes to muscle growth, Sermorelin is probably the big winner, though this can be debated endlessly. Sermorelin not only boosts muscle hypertrophy and hyperplasia, it reduces fat mass and thus causes a shift in body chemistry toward lean body weight. In other words, Sermorelin will always favor the production of lean body mass even if diet is not perfectly geared toward muscle development. Ipamorelin, on the other hand, is more of a mixed bag. It will always cause muscle growth, but ipamorelin may channel some of those calories into fat deposition as well.

Ipamorelin vs Sermorelin: Anti-Aging Properties

Both Ipamorelin and Sermorelin, via their GH releasing potential, have potent anti-aging properties. Sermorelin, however, is the clear front runner in this particular face off. Sermorelin has been shown to improve joint function, skin thickness, skin collagen structure, wound healing, cardiac fibrosis, strength, and metabolism. According to Dr. Richard Walker, Ph.D., of the International Society for Advanced Research in Aging, Sermorelin helps to preserve more of the growth hormone axis than most other GHRH analogues, resulting in a more youthful hormone profile. In other words, if you took profiles of GH biochemistry throughout an individuals lifetime, you would find that Sermorelin tends to dial back that chemistry to a more youthful setting.

Ipamorelin as Pain Reliever

One of the biggest differences between Ipamorelin and Sermorelin lies in the fact that Ipamorelin triggers the release of neuropeptide Y. This peptide is an important neurotransmitter in the control of appetite and food preference, but it also plays an important role in how we perceive pain. In fact, the connection between food and good feelings is likely due, in part, to the effects of neuropeptide Y.

Research in rats indicates that Ipamorelin may help to reduce pain perception by has much as 2-fold. This is particularly true of visceral pain, which is to say stomach pain. Visceral pain is difficult to treat, so ipamorelin offers a potential starting point for understanding how to better control the pain associated with conditions like irritable bowel syndrome, Crohns disease, ulcerative colitis, and more. There are also potential applications in neuropathic pain syndromes like diabetic neuropathy and degenerative disk disease[9].

Sermorelin and Sleep

Research in rats shows that Sermorelin is an effective regulator of the sleep cycle. Sleep and aging go hand int hand, with one affecting the other such that older people often have less adequate less restful sleep. Sermorelin appears to achieve its sleep benefits by regulating orexin release from specialized neurons in the brain. Orexin is an important neurotransmitter in sleep regulation and Sermorelin appears to boost orexin secretion. This leads to an increase in non-REM slow-wave sleep, which is associated with more restful sleep, improved immune function, better wound healing, and happier mood[10], [11]. Its effects on sleep may be one of the reasons that Sermorelin is a potent anti-aging peptide.

Sermorelin vs Ipamorelin: Summary

Sermorelin peptides and Ipamorelin peptides are more similar than they are different, but that doesnt mean there arent distinctions between these two growth-promoting peptides. Practically speaking, Sermorelin is the all-around peptide. It promotes lean body mass gains, boosts fat burning, and fights the effects of aging. It is also a more holistic simulator of the GH axis and, as such, helps the body to maintain youth-like patterns of GH secretion.

Ipamorelin is the more potent of the two peptides. Its effects are large, but relatively short-lived. Ipamorelin is a gainer peptide. It builds lean body mass, but also builds overall body mass. It is a potent stimulator of bone growth and has some pain fighting properties as well.

There has been some research investigating the effects of combining Sermorelin and Ipamorelin. Because these peptides affect two different receptors, their actions when combined tend to be synergistic. Unfortunately, the research in this area is limited, so there isnt a great deal of data on how the combination of these two peptides can help to improve appetite, alter body composition, fight off cardiovascular disease, slow the progression of aging, and promote general good health. In the end, both Ipamorelin and Sermorelin have been studied extensively, but individually, for their significant impacts on GH. Both peptides are effective, but have slightly different ancillary effects that have driven researchers in different directions as they explore potential applications for ipamorelin peptides and sermorelin peptides.

Resources

[1] M. L. Heiman, M. V. Nekola, W. A. Murphy, V. A. Lance, and D. H. Coy, An extremely sensitive in vitro model for elucidating structure-activity relationships of growth hormone-releasing factor analogs, Endocrinology, vol. 116, no. 1, pp. 410415, Jan. 1985, doi: 10.1210/endo-116-1-410.

[2] V. A. Lance, W. A. Murphy, J. Sueiras-Diaz, and D. H. Coy, Super-active analogs of growth hormone-releasing factor (1-29)-amide, Biochem. Biophys. Res. Commun., vol. 119, no. 1, pp. 265272, Feb. 1984, doi: 10.1016/0006-291x(84)91647-4.

[3] A. Grossman et al., Responses to analogues of growth hormone-releasing hormone in normal subjects, and in growth-hormone deficient children and young adults, Clin. Endocrinol. (Oxf.), vol. 21, no. 3, pp. 321330, Sep. 1984, doi: 10.1111/j.1365-2265.1984.tb03477.x.

[4] R. F. Walker, Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?, Clin. Interv. Aging, vol. 1, no. 4, pp. 307308, 2006, doi: 10.2147/ciia.2006.1.4.307.

[5] Y. Sun, P. Wang, H. Zheng, and R. G. Smith, Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor, Proc. Natl. Acad. Sci. U. S. A., vol. 101, no. 13, pp. 46794684, Mar. 2004, doi: 10.1073/pnas.0305930101.

[6] J. V. Gobburu, H. Agers, W. J. Jusko, and L. Ynddal, Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers, Pharm. Res., vol. 16, no. 9, pp. 14121416, Sep. 1999, doi: 10.1023/a:1018955126402.

[7] N. B. Andersen, K. Malmlf, P. B. Johansen, T. T. Andreassen, G. rtoft, and H. Oxlund, The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats, Growth Horm. IGF Res., vol. 11, no. 5, pp. 266272, Oct. 2001, doi: 10.1054/ghir.2001.0239.

[8] J. Svensson et al., The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats, J. Endocrinol., vol. 165, pp. 56977, Jul. 2000.

[9] E. N Mohammadi, T. Louwies, C. Pietra, S. R. Northrup, and B. Greenwood-Van Meerveld, Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics, J. Exp. Pharmacol., vol. 12, pp. 267274, 2020, doi: 10.2147/JEP.S249747.

[10] B. S. Shepherd et al., Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout (Oncorhynchus mykiss), Comp. Biochem. Physiol. A. Mol. Integr. Physiol., vol. 146, no. 3, pp. 390399, Mar. 2007, doi: 10.1016/j.cbpa.2006.11.004.

[11] A Good Nights Sleep, National Institute on Aging. http://www.nia.nih.gov/health/good-nights-sleep (accessed Nov. 22, 2020).

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Sermorelin vs Ipamorelin: Best Guide in 2022 - PeptideSciences.com


Jun 10

Tips for Business: How to Create a Team of Professionals From Beginners – The Roanoke Star

As the economy improves, more and more people start their businesses. This can be a daunting task for someone who has never worked on a team before. When people work without much experience working in groups, they often become overwhelmed by the task and quit before finishing anything. To ensure that your team can make it through business-building, its essential to learn how to keep yourself organized and focused while building chemistry with other people.

Tips for building professionals from beginners

One thing that scares people about hiring newbies is losing their productivity. It can be avoided by involving them in your new process. A simple example would be sending out a reminder email or making sure they know project deadlines and goals. Still, you can also involve them in product concept development and design, giving them input on features they like.

The key to productivity is not talking but, instead, doing. If you have a more talented person on your team and arent willing to help, you already know you cant get production out of them. It would help if you showed them that by communicating with the team regularly and showing them the results of the work they have produced. It can be as simple as commenting on their previous work or as complex as giving a feedback session after each project.

One of the things that can make an incompetent person productive is the feeling of pride that comes from knowing theyre helping others. Make your team members feel proud when they help you with problems, or show off this by making it a point to thank them for their hard work on one of their projects. Doing this will encourage your employees to put in more effort and provide better quality outputs. This also works well for teams, who may feel more motivated by service offers than money.

Rewarding your employees is something you probably do with friends or family, but it can work wonders for a team. Since incentives are purely based on motivation, this is a great way to keep a team of people working hard and motivated to come back every morning. Giving them bonuses and praise as they work can make your team more productive and more money!

One of the things that can hurt productivity is bossiness. This doesnt work for many people as it can cause them to lose interest and motivation. Try to be a benevolent dictator and give them clear goals and strategies. This way, you can get their best output without putting unnecessary pressure on them.

The biggest mistake we make in todays market is working against each other instead of working together on the same project. Many reasons can cause this breakdown, but the main problem is that we are working for high stakes. Instead, your employees should be aware that they are committed to their job and that you have a commitment to them. This will make them think twice before going to work without showing up and doing whats needed.

How to motivate your team

Let your team go to work at their own pace, and dont get in their way unless youre asking for help. If you do it this way, they are more likely to deliver whats promised and get the best out of themselves.

Show your employees that you respect them by talking to them and how you treat them. Please dont get too personal with your employees, and dont talk down to them like children. If they release lousy work, dont yell at them; instead, help them improve or give specific directions on how to do it better. Respect builds loyalty which is just another thing that makes for a more productive team!

This is one of the most important things you can do to motivate your team and let them know that you appreciate their hard work. Feedback is a form of recognition, and its also important because it allows them to learn and improve. You can give feedback by sharing their work with the rest of the team, or you can give them points on their performance so that if they dont meet expectations next time, theyll be able to improve.

When employees are not motivated and are not having fun at work, they stop showing up and get less productive. This can be fixed by ensuring that they like their job and are happy and enjoying their work, but its also essential to give them a break. Have fun!

Causes of poor performance

This is one of the leading causes of poor performance at work because it keeps you from being able to concentrate on your tasks and causes nausea, dizziness, flu-like symptoms, and loss of appetite. The other reason this causes poor performance is that it makes you sick and tired, which will cause you to have more health issues at work. Considering Sermorelin therapy, first make sure your blood work proves your HGHD.

This is the most common cause of poor performance that you can find on the internet. People who work long hours are more likely to get sick and dont take good care of themselves, which causes them to have a lot of health issues at work.

This is one of the biggest reasons for poor performance, and it is something that many people dont think about until they have a severe illness or injury. Depression is a disease that keeps a person from being able to concentrate or focus on their job. This can be caused by many things, like a broken relationship or losing a close family member. The best thing you can do for your team is to make sure they are supported and happy.

When your employees are happy, they will be more productive, but they will want to help you out and do what you need. All these things combined make for a better team of happy and healthy people. This can be achieved by giving your employees the proper training and motivation and letting them take breaks and go home early when they need to get rest.

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Tips for Business: How to Create a Team of Professionals From Beginners - The Roanoke Star


Jan 12

90 Day Fianc: Stephanie Davison Reveals The Secrets To Her Youthful Looks – Screen Rant

Skin Envy owner Stephanie Davison often makes many 90 Day Fianc fans envious of her youthful looks. The TLC star, 52, has now confessed her secrets.

Although Stephanie Davidson from 90 Day Fianc is making waves for her relationship with her Belize boy toy Ryan Carr, it's also her looks that have fans saying "wow." Sure, being the face of a business that makes one "remove fat" helps, but what is that keeps Stephanie looking so good at 52? The 90 Day Fianc star Stephanie has revealed what is her fountain of youth on her Instagram page.

As fans try to decipher why a successful, independent woman like 90 Day Fianc's Stephanie could choose to date someone like Ryan, they also have started guessing the relationship won't last long. With Stephanie mentioning that Ryan had been talking to other women in spite of her paying for his bills for three years, the possibility of her choosing his cousin Harris might become a reality. A traumatic childhood and then loveless adulthood is what Stephanie finally left behind when she decided to couple up with Ryan. But a recent episode saw the 90 Day Fianc star shocking her friends with the revelation that she pays for Ryan's salary too. Of course, her sleeping with Ryans cousin could have made her guilty enough to pay his bills but TLC viewers couldnt help wondering if Stephanie was getting played. After all, a Maserati-driving, successful boss woman who looks way younger than her years could date anyone, right? Especially if the self-proclaimed sugar mama whose Instagram comments are filled with 90 Day Fianc fans asking Stephanie for her secret to looking half her age.

Related:90 Day Fianc: Throwback Video Shows Stephanie Selling Sermorelin Injection

Not surprisingly, 90 Day Fiancs Stephanie has been a fan-favorite since season 8s premiere even though she appeared on the reality show weeks later. Fans were curious about this cat-lady who was calling herself a cougar and Ryan her cub as she sent him expensive watches in the trailer. The Grand Rapids lady soon gained more interest by hosting expensive giveaways for handbags on her Instagram, which some 90 Day Fianc couldnt help but love her for. However, it was Stephanies weigh-loss spa Skin Envy that made her much more interesting. As expected, the 90 Day Fianc stars age-defying routine owes a lot to her own business.

When asked by an IG follower, How can I look like you? 90 Day Fiancs Stephanie replied, Well, the Youth Serum Sermorelin/Ipamorelin shots are $4500 a year. But Stephanie also gave an alternative option by suggesting, dont drink much alcohol, get at least 8 hours of sleep at night. Ryans Michigan lover also revealed that she drinks at least 8 glasses of PURIFIED water daily. And for exercise, 90 Day Fiancs Stephanies go-to is a hula hoop.

The curious TLC viewer further enquired Stephanie about her injections as she wrote, can I buy them from your store, and can you ship them? And the marketing maverick that she is, 90 Day Fianc star Stephanie shared, Call my medical assistant Pam. Spoilers suggest that Stephanie will be dumping Ryan while in Belize next and coming back to America with cousin Harris. But while that may take a while to happen on 90 Day Fianc, one things for sure, Stephanie is surely going to get a lot of calls at Skin Envy, all due to the fans who are in awe, if not envious of her own beauty.

Next:90 Day Fianc: Shocking Details Of Jovi Dufren's Criminal Past Revealed

90 Day Fianc airs Sundays at 8pm EST on TLC.

Source: Stephanie Davison/Instagram

90 Day Fianc: Yazan's Fans Turn Into Haters After Seeing His New IG Pic

Saylee Padwal is a Reality TV Features Writer for Screen Rant. When she's not thinking about pop-culture or food, you can always find her "investigating" her way through Instagram, reading mysteries and thrillers, and listening to BTS on loop.

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90 Day Fianc: Stephanie Davison Reveals The Secrets To Her Youthful Looks - Screen Rant


Jan 9

’90 Day Fiance’: What is Stephanie Davison’s job and net worth? Truth behind 80 pounds weight loss from inject – MEAWW

'90 Day Fiance' stars Stephanie Davison and Ryan Carr's relationship never really took off. It's been a little over a month since Season 8 of the show has premiered but there's been no progress on that front. The couple is yet to share their stories fully on television.

However, in this week's episode, we learned more about Stephanie and the kind of work she does for a living that kept her from focussing on love and marriage so far. Here's all we know about the Skin Envy place where she works. If you're wondering if that's the secret to her drop-dead gorgeous look, here's the truth.

She is an entrepreneur and operates two medical spas out of Michigan. Skin Envy was designed for clients looking at easy age reversal and weight loss options. Stephanie has been making good sales out of her two outlets and what seems to have worked for her is trying some of these shot serums on herself. She injects herself with Sermorelin, which apparently wakes up her pituitary gland and that helps restore youth.

Her clinics also offer HGC injections for those wanting to shed a few extra kilos. The shots "stimulate the bodys natural ability to produce HGH leading to renewed energy, sex drive, lowered body fat and so much more," her website writes. Woah!

This aside, the spas also have mesotherapy, hydra facial, infrared sauna, and more on the roster. But how effective are these treatments? The testimonials on the Skin Envy site is proof enough. "My love handles would not go away no matter how much I would diet or exercise. Mesotherapy has helped me to get a more shapely waist!," Jan M reviewed the treatments.

Also, Stephanie had two of her cousins, Shannon and Ryanne, visit her on the show. Apparently, Shannon lost 80 pounds by Skin Envy's methods and so Ryanne wanted to test it out and see if she can achieve similar results and it clearly worked for her!

Although her '90 Day Fiance' paycheck is not known, her estimated net worth from all the successful businesses she owns is at $1.5 million, Starsoffline reported.

Catch all the new episodes of '90 Day Fiance' on TLC every Sunday at 8/7c. For more information, check your local listings.

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'90 Day Fiance': What is Stephanie Davison's job and net worth? Truth behind 80 pounds weight loss from inject - MEAWW


Oct 28

What Are the Benefits and Side Effects of Sermorelin …

As we head into our 40s and 50s, things begin to change really change. By the time we reach our 60s, we question why everything seems to have gone south. The reason why your body feels and looks different is that it is different. Our bodies stop producing the human growth hormones they produced when we were younger. Thankfully, sermorelin can replenish insufficient HGH levels. Revive Medical Center uses this treatment to help their patients rebuild and repair damaged and weakened cells.

Although it takes a few months of treatments to really experience the benefits of sermorelin, many of our patients feel that the benefits are worth the wait. The results of sermorelin therapy include

This might sound too good to be true but when you think about how sermorelin works, it makes perfect sense. Sermorelin encourages your pituitary gland to produce HGH, the hormone it produced when you were younger. It helps your body restore the hormone levels lost during the aging process.

This anti-aging treatment comes with minimal side effects, which also makes it appealing to patients. Sermorelin is administered through an injection, and some patients report discomfort at the injection site. There might be some minor pain, redness, and/or swelling. On rare occasions, a handful of patients have also reported itching and difficulty swallowing, suggesting an allergy to the treatment.

Other rare side effects include dizziness, flushed skin, headaches, insomnia, and restlessness. These side effects are uncommon, and wed be happy to discuss any concerns you might have about the sermorelin treatment before you begin the program. In most cases, sermorelin is a more effective anti-aging treatment with fewer side effects than other HGH replacement therapies.

If you are interested in learning more about sermorelin anti-aging treatments, call Revive Medical Center at 678-701-6397.

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What Are the Benefits and Side Effects of Sermorelin ...


Oct 10

Home – Sermorelin

In total, there are 20 different amino acids. They all have vastly different properties and exert different effects within the system.

Whilst a protein may contain 50 or more amino acids, the balance of the amino acids it contains ultimately determines what kind of impact it will have on the body.

The same goes for peptides too; amino acids can lead to everything from CNS (Central Nervous System) responses to the replenishment and evolution of organ tissue and muscle cells.

We can only synthesise 11 of these 20 amino acids on our own using our internal mechanisms; we need to source the other 9 (known as essential amino acids because they are essential components of our nutritional intake) from food meaning that the spectrum of benefits on offer by the proteins and peptides we naturally produce are somewhat resigned to the effects on offer with these 11 acid types only.

Bioengineering allows us to combine these 11 man made amino acids with any number of the other 9 essential amino acids to produce compounds that are capable of exerting varying effects on the body.

Not only that, but we can actually choose to alter the structure of either essential or nonessential amino acids, further manipulating the effects they can exert.

Regardless of the manner in which a peptide or protein is created (either naturally occurring or unnaturally synthesises in a laboratory) the crux of the entire operational efforts of these molecules is indeed the amino acid code contained within.

As previously stated, these individual acids can lead to any one of several responses within the body combining them together can exert either multiple or one primary effect.

Its still not entirely known how certain amino acid sequences can lead to certain effects occurring.

Being that amino acids are considered to be the building blocks of the human body, it is perhaps possible that each and every hormone / enzyme contains its own unique amino acid code, and once discovered, the effects of said hormone or enzyme can be recreated / replicated.

That certainly appears to be the case in this instance, because the 29 amino acid code contained within sermorelin directly mimics the effects of growth hormone releasing hormone.

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Jun 28

Peptide Therapy The Growing Traction – MMA Corner

Aging, its something every one of us is concerned about as it brings a lot of frustrating changes that are an inevitable part of life. As we reach 50, we face a number of problems such as weight gain, wrinkles, increased lipid levels, and many other problems. While some of these problems are not preventable but we can take some steps to improve health and well being so that we can sense our best despite what age we are. This is where peptides therapy helps.

What Are Peptides?

Peptides are biological molecules present in all living organisms and produced naturally by the body. Like proteins, peptides are also made up of amino acids that are linked together to form a short chain of amino acids. They function as a signaling molecule inside the human body, commanding other molecules and cells on what functions to perform. Our body has more than 7000 known peptides, and every peptide perform different functions, including immune system health, hair loss, weight loss, and many more.

What Is Peptide Therapy?

Peptides are produced in the body naturally, but the production of peptides varies in individuals, and as we age, we can see a decline in the production of peptides. This therapy is something we are hearing about now, perhaps but will be very popular therapy in the future.

Peptides are amino acids that can actually be developed to stimulate the receptors to create the effect. For instance, if you want to stimulate growth hormone, we can develop a peptide to actually work on a receptor site, to stimulate the pituitary gland that can naturally produce growth hormone.

Benefits of Peptide Therapy

As there are so many peptides, peptide therapy has a wide range of benefits, including hair loss, weight loss, enhance the immune system, improved cognitive function, and some more. Below are some benefits of this therapy.

One particular peptide, called peptide CJC 1295, helps in increasing the production of an essential growth factor in the human body. Usage of this peptide during treatment leads to lean muscle growth, fat loss, and better sleep.

Another peptide includes ipamorelin, and sermorelin increases the production of growth hormone, thereby boost in stamina and lean muscle mass and reducing the refractory time during the workout.

Thymosin alpha-1 (TA-1) enhances the bodys capability to fight against the harmful virus, and bacteria TA-1 is the most used peptide in the therapy, as many young people have chosen to strengthen their immune system with the help of this hormone.

Apart from TA- 1, cerebrolysin is another peptide commonly used in the therapy because of its intensification of few brain functions. It is also proven that cerebrolysin has also improved short and long term memory and increase motivation.

These are some popular forms of peptides treatment, Apart from these, there is much more therapy presents out there, and their benefits include.

Why Should Peptide Therapy Be Used?

Apart from all the benefits, it is a very safe and effective treatment that will not cause any major side effects. So, if the above-mentioned benefits sound engaging to you, consider having a word with your doctor to know more about peptide therapy.

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Feb 24

Sermorelin Acetate (Sermorelin): Uses, Dosage, Side Effects …

WARNINGS

No information provided.

General: Sermorelin acetate therapy should be carried out under the regular guidance of a physician who is experienced in the diagnosis and management of growth hormone deficiencies.

In clinical studies, the incidence of hypothyroidism during Sermorelin therapy was 6.5%. In the largest clinical study, 8 of 110 enrolled patients were on thyroid replacement therapy prior to Sermorelin therapy and an additional 5 after initiating therapy. Untreated hypothyroidism can jeopardize the response to Sermorelin . Therefore, thyroid hormone determinations should be performed before the initiation and throughout the duration of Sermorelin therapy. Thyroid hormone replacement therapy should be initiated when indicated.

Patients with growth hormone deficiency secondary to an intracranial lesion were not studied in clinical trials. It is not recommended that such patients be treated with Sermorelin .

As with the administration of any peptide, local or systemic allergic reactions may occur. P atients should be informed that such reactions are possible and that prompt medical attention should be sought if allergic reactions occur.

Laboratory Tests: Serum levels of inorganic phosphorus, alkaline phosphatase, GH and IGF-1 may increase with Sermorelin therapy.

Carcinogenesis, Mutagenesis, Impairment of Fertility: Long-term animal studies for carcinogenicity and impairment of fertility have not been performed with Sermorelin . There has been no evidence from studies to date of Sermorelin -induced genetic toxicity.

Pregnancy: Pregnancy Category C. During teratology studies Sermorelin produced minor variations in fetuses of rats and rabbits when given at a dose of 0.5 mg/kg/day. This dose is approximately 3 and 6 times the daily human dose calculated on a body surface area (mg/m 2 ) basis, for rats and rabbits, respectively. There are no adequate and well controlled studies in pregnant women. Sermorelin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing Women: It is not known whether Sermorelin is excreted in human milk. Because many drugs are excreted in human milk, cautions should be exercised when Sermorelin is administered to a nursing women.

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Sermorelin Acetate (Sermorelin): Uses, Dosage, Side Effects ...


Feb 19

Side Effects of Sermorelin Acetate (Sermorelin), Warnings …

SIDE EFFECTS

A large proportion of patients develop anti- GRF antibodies at least once during treatment with Sermorelin. The significance of these antibodies is not clear and often a positive test at one growth assessment will become negative by the next assessment. The presence of antibodies does not appear to affect growth or appear to be related to a specific adverse reaction profile. No generalized allergic reactions to Sermorelin have been reported.

The most common treatment-related adverse event (occurring in about 1 patient in 6) is local injection reaction characterized by pain, swelling or redness. Of 350 patients exposed to Sermorelin in clinical trials, three discontinued therapy due to injection reactions. Other treatment-related adverse events had individual occurrence rates of less than 1% and include: headache, flushing, dysphagia, dizziness, hyperactivity, somnolence and urticaria.

When administered intravenously for diagnostic use, the following adverse reactions have been noted: flushing of the face, injection site pain, redness and/or swelling, nausea, headache, vomiting, dysgeusia, pallor and tightness in the chest.

The clinical pharmacology suggests that Sermorelin is very unlikely to be associated with drug abuse or dependence and there have been no reports of this from clinical trials.

Read the entire FDA prescribing information for Sermorelin Acetate (Sermorelin)

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Side Effects of Sermorelin Acetate (Sermorelin), Warnings ...



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