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Jul 18

How to gain or lose weight in Once Human – Sportskeeda

One of the many immersive mechanics in Once Human is the ability to gain or lose weight organically. Buried beneath a complex web of mechanics, the nourishment system in this game feeds into a weight class mechanic the game does not tell you about. Naturally, much like in real life, you can tuck on a few pounds without knowing about this invisible meter.

Thankfully, losing weight in Once Human is much easier than in real life. In this guide, we will go over how.

The easiest way to lose weight in Once Human is to eat food that will give you the Gastric Discomfort debuff. Simply hunting some deer and eating the uncooked meat will induce this effect, for example. Other methods include directly drinking dirty water without boiling it or eating spoiled food.

As long as you have this debuff, you will gradually lose weight. However, the weight loss is a mere side-effect of the real penalty - which is decreased maximum HP. Thankfully, you can also cure Gastric Discomfort by crafting Antibiotics from the Supplies workbench.

If you're in a PvP server and want a less risk-averse way of losing weight in Once Human, you can resort to food that has the 'Weight Watchers' buff, including Fat-burning Juice.

Also Read: All active Once Human Redeem Codes

To gain weight in Once Human, all you have to do is eat food items tagged with Muscle-building. These are most food items cooked with Corn Oil, such as Fish and Chips. These are pretty advanced recipes that require some Memetic Point investments into cooking perks, though.

An alternative method is getting the Extradimensional Cat Deviant companion. Sleeping with this companion equipped will cause you to gain weight at quite a rapid rate.

Read More: All Deviant companions in Once Human

Why would you want to gain or lose weight? To make better use of the game's player weight mechanic. You are assigned a weight class during the character creation stage of Once Human depending on your 'Fitness' slider.

The gist of the mechanic is that each weight class incentivizes specific gameplay approaches with buffs and debuffs.

Generally, you want to stay in the moderate weight class to get the best buffs. This is why you will eventually have to resort to one of these methods to manipulate your way past the character creation menu.

This concludes our guide to gaining or losing weight in Once Human. Check out our other articles on this game here:

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Edited by Abhipsito Das

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How to gain or lose weight in Once Human - Sportskeeda


Jul 18

Wrestlers Told To Lose Weight Or They Would Be Fired – Wrestling Inc.

Keith Lee's "WWE NXT" success story seemed to position the star for a major main roster run, and many fans were filled with excitement for what he could accomplish on "Raw" or "SmackDown." Unfortunately, Lee's main roster run remains one of the worst call-ups in recent history, and it was largely due to his physique.

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Speaking on"Talk is Jericho," Lee looked back at his run with WWE, and noted how the promotion forced him to undergo many changes, such as not performing many of the athletic moves he's known for. "I am 100% certain it was some sort of an attempt at a test or such," he said.

Additionally, even when he rebranded himself as "Bearcat" Keith Lee, the company continued to strip away his move set. "Where the double chop I've been known for, they snatched that. They didn't want me looking at the crowd at all."

However, things didn't end there for the former WWE Superstar. According to a report from"Wrestling Observer Newsletter," after Lee contracted COVID-19, his physical ability worsened and he looked visibly bigger compared to when he first got sick. Sadly, this ended up being one of the believed reasons for Lee's WWE release.Furthermore, Lee's health issues are still a cause for concern today, and he's currently not been featured for months on AEW programming due to his continued struggles.

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Wrestlers Told To Lose Weight Or They Would Be Fired - Wrestling Inc.


Jul 18

1000-Lb Sisters Star Amy Slaton Is Living Her Best Life After Weight Loss Transformation – Screen Rant

Summary

Amy Slaton from 1000-lb Sisters recently shared a fun dance video on TikTok celebrating her life after losing weight. The 36-year-old mother of two was once over 406 pounds, feeling unhappy and stuck in a stagnant lifestyle. Amy struggled to lose weight and change her eating habits, especially because of her close relationship with her best friend and sister, Tammy Slaton, who faced similar challenges. Finally, Amy decided it was time to prioritize her health and opted for weight loss surgery, leading her to shed over 125 pounds.

Amy has become much happier since having two babies and her divorce from her husband, Michael Halterman.

She is living her best life in 2024 and enjoys sharing it on social media. Amy's friend, Ollisha Davis, recently posted a TikTok video titled "the time is now! You work hard, but you gotta live hard." The clip showed the 1000-lb Sisters star dancing with her friend and appearing slimmer than before.

Amy looked cheerful in the video and posed for the camera. She flaunted her defined jawline and walked to a car, indicating she was now fit enough to move quickly.

Reality TV is more popular than ever. With so many to choose from, here are some of the best reality TV shows to stream or watch right now.

Amy has made significant progress since losing 124 pounds over the past three years. The Dixon, Illinois native is now physically fit and mentally stronger. She leads an active lifestyle, balancing parenting her two kids and spending time with friends. Tammy's recent weight loss has also had a positive impact on Amy. Both sisters have become more fit and no longer encourage each other to engage in unhealthy habits. Instead, they inspire each other to continue their fitness journey and stay active. Amy's recent dance video shows her growth, which is why 1000-lb Sisters fans continue to support her.

Amy deserves all the likes and positive comments she receives. She has truly accomplished what many thought was impossible. Amy has lost weight and achieved numerous milestones, including becoming a mother and completely changing her lifestyle.

In 2024, Amy lives a healthy life that inspires her over 648k followers. She prioritizes her health and puts all her effort into caring for her children. Unfortunately, the reality star recently experienced significant marital problems with her estranged husband, Michael. Hopefully, 1000-lb Sisters season 6 will reveal what the future holds for Amy.

Amy isn't the only cast member of 1000-lb Sisters who has turned her life around. Tammy has also followed in her younger sister's footsteps and completely transformed her life in the last two years. She has successfully lost 440 pounds and now loves sporting fashionable outfits. Amy's other siblings have also achieved similar weight loss milestones. Amy's brother, Chris Combs, has lost over 150 pounds. Her half-sister, Amanda Halterman, has also shed significant weight, as seen in her latest pictures. Hopefully, Amy's journey toward weight loss will keep motivating 1000-lb Sisters cast members to keep reaching their fitness goals.

Tammy Slaton

37 years old

Lost 440 pounds

Diet, exercise, weight loss surgery

Amy Slaton

36 years old

Lost 125 pounds

Diet, exercise, weight loss surgery

Chris Combs

41 years old

Lost 150 pounds

Diet, exercise, weight loss surgery

Amanda Halterman

43 years old

Lost 300+ pounds

Had weight loss surgery (twice)

Misty Wentworth

48 years old

Unknown

Had weight loss surgery

1000-Lb Sisters is available to stream on MAX and Discovery Plus.

Source: Ollisha Davis/TikTok

1000-lb Sisters follows sisters Amy Salton-Halterman and Tammy Slaton in their home in Dixon, Kentucky, covering their daily lives, weight loss attempts, and subsequent weight loss surgery. The show covers such moments as attempts to have children, medical visits, and dramatic emergency room visitations. The family wrestles with supporting their daughters and their weight loss efforts while struggling with their own life troubles.

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1000-Lb Sisters Star Amy Slaton Is Living Her Best Life After Weight Loss Transformation - Screen Rant


Jul 18

Jon Gosselins daughter Hannah reveals how much weight she lost with semaglutide – Page Six

Jon Gosselin and his daughter Hannah Gosselin shed a combined total of 75 pounds by using a base semaglutide the primary ingredient in popular weight-loss drugs like Ozempic and Mounjaro.

The former Jon & Kate Plus 8 stars didnt name the medication they used, but Hannah revealed she lost 25 pounds, and Jon shed more than 50 pounds.

I feel great. Im really happy, Hannah, 20, told Entertainment Tonight in an interview published Tuesday.

The father-daughter duo worked with Dan Holtzs Beverly Hills Rejuvenation Center where they each got a prescription for the popular weight-loss drug.

When I put on my pair of shorts that I wore two years ago I danced around my room. I was so happy. It was the best feeling ever. You probably would not have caught me in a swimsuit last summer. I dont even think I went to the beach, Hannah raved.

She added, I have been spending my whole summer at the pool, at the beach, out with my friends. It really is a confidence booster to know that you look in the mirror and youre happy with the way that you look.

In addition to the injections, Jon, 47, also underwent CellSound treatments a non-invasive treatment to stimulate cells and give skin a more youthful appearance and testosterone adjustments.

I think confidence level. I work out at the beach and sometimes I dont wear a shirt because its 100 degrees outside now. Before I would just sweat through it, now [I take it off].I have these things called abs. They just appeared, Jon gushed.

Both Jon and Hannah are now working on weaning ourselves off of the semaglutide and continuing to live an active lifestyle that centers around working out and eating high-protein meals.

Itll be a short-term plan thatll help us get to where we want to be. Once we get to our goal then its really going to be teaching Jon the lifestyle and how to maintain healthier lifestyle choices, Holtz previously told ET.

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Jon spoke to Page Six in April and revealed that he had lost 32 pounds in two months.

You know whats annoying? The regret of not starting it 10 years ago. I feel amazing! Like, why didnt I do this sooner? Maybe it wasnt the right time, he told us at the time.

The former TLC star added that the medication also helped me stop drinking and get his appetite under control.

I was able to really refocus my diet that way. I just focused on consuming what I need to consume in a healthy manner, he shared.

Jon previously admitted that he gained 35 pounds after he began DJing full time from around 10 p.m. to 2 a.m. several nights a week and quit his IT job.

Jon rose to fame with the hit show Jon & Kate Plus 8 with his ex-wife, Kate Gosselin, and their eight kids, including Hannah. However, the two separated in 2009 and had a tumultuous divorce that resulted in him being estranged from six of their children.

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Jon Gosselins daughter Hannah reveals how much weight she lost with semaglutide - Page Six


Jul 18

People Swear by Mini Steppers for Weight Loss – Eat This, Not That

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If you've been on social media lately, you've likely seen the hype surrounding "mini steppers." This nifty piece of workout equipment is seamless to use and delivers results from the comfort of your own home. In fact, people on TikTok are adding them to their home workout routines to lose weight and get into the best shape.

Not only will a stair stepper help you slim down, but it will also aid in boosting endurance, aerobic fitness, and functional movement. Plus, it's oh-so-easy to store as well if you live in a smaller space or simply don't want it out when you're not using it.

We learned everything there is to know about using a mini stepper in your fitness regimen, including its benefits and how often you should use it.

Whether you'd like to upgrade your at-home workout setup or are concerned about weight loss, mini steppers are what your cardio sessions have been missing. Mini steppers are perfect no matter your fitness level. Some even come equipped with resistance bands or handles so you can turn your cardio days into full-body workouts. 6254a4d1642c605c54bf1cab17d50f1e

This Niceday stepper on Amazon, for instance, is a #1 best-seller among Amazon's step fitness machines. It comes with resistance bands and boasts a smooth hydraulic system and silent silicone cushioning pad for seamless, quiet movement.

Treadmill or Stair Climber: Which Is More Effective for Weight Loss?

"One of the biggest benefits of using a mini stepper is the convenienceit's the perfect piece of equipment for small spaces and can easily be moved. So if you get snowed in and can't go to the gym or want to get a workout in while your kids nap, a mini stepper is the way to go," explains Ronny Garcia, CPT, Blink Fitness.

Heckif you work from home, you can even step away while chatting with the team or listening to a podcast for a little break. In addition, for those on a budget, a mini stepper is a more affordable option than a treadmill or full-size stepper.

"Similar to a full-size stepper or going out for a walk, a mini stepper provides a great cardio workout, which helps improve heart health and endurance," Garcia adds. "The stepping movement targets the lower body muscles, leaving your thighs, calves, and glutes toned."

This Stair Climber Workout Will Help You Sculpt Lean Thighs

People are here for mini steppersand for good reason.

TikTok user @dimezwrld felt inspired to test one out after seeing the social media hype. "I'm [going to] cancel my gym membership, like, right now. Because, girl, I've been paying $30 a month when I could just pay $64 for a mini stepper and be at home," she said in her video. "I've seen all the girlies on TikTok buy stepping machines so I'm like, let me try it on my own after like 30 minutes of this, I got like 800 steps."

The Viral "25-7-2" StairMaster Workout Is Worth the Sweat

Another TikToker, @christinasciblo, raved in a clip, "I did this mini stepper challenge, which allowed me to walk on my time. I started this challenge at 175my highest weight ever. After 30 days of walking one mile, I'm 169."

Research shows that aerobic training, such as working out on a mini stepper, can significantly decrease body weight and fat mass.

"Exercising on a mini stepper is the same as any other workout. You're moving your body, and that burns calories," says Garcia. "Moving faster or extending your exercise time will increase the calories burned."

Garcia stresses the importance of consistency when it comes to how often you should use the mini stepper for weight loss. He suggests using this piece of workout equipment three to five times a week for 30 to 60 minutes. "If you only have 15 minutes, that's fine! Just stay consistent," Garcia adds adds.

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People Swear by Mini Steppers for Weight Loss - Eat This, Not That


Jul 18

Drastic caloric restriction by athletes diminishes performance and compromises the immune system – News-Medical.Net

Drastically cutting back on caloric intake to lose weight ahead of competition is commonplace among athletes. However, this type of 'dieting' doesnt just diminish performances, it can also compromise their immune systems. These are the findings of a new study from the University of Copenhagen.

Whether selected to swim, row or run in the Olympics, or gearing up to ride in the Tour de France, achieving the 'right' weight has been a focal point of many elite athletes for decades. It could be to look lean and mean in a swimsuit or jersey, or to qualify for a certain weight category. But there is also a belief that losing weight enhances performance.

As such, it is a widespread phenomenon among athletes especially in endurance sports like running, swimming, cycling and rowing to reduce their dietary intake in the run-up to competition.

It is particularly problematic among female endurance athletes. Many athletes focus heavily on weight in their respective sports. Consequently, they tend to go into short-term, but intense periods of weight loss with the expectation of performing better."

Professor Ylva Hellsten of the University of Copenhagen's Department of Nutrition, Exercise and Sports

She and PhD student Jan Sommer Jeppesen are two of the researchers behind a new study on the effects of low energy availability among female athletes.

"We know that the phenomenon of not eating enough is associated with many things that are harmful to health including missed periods, compromised bone health and changes in metabolism. But there is still plenty that we don't know. As such, we investigated some of the possible consequences more closely," says Jeppesen, who is the study's lead author.

For the study, the researchers recruited twelve female triathletes, all of who had a normal energy intake. During one part of the trial, the athletes were given enough calories for 14 days, after which their performance was tested. The same athletes also went through a 14-day period during which they consumed only about 50% of their energy needs while sticking to their normal intensive training schedule.

During the period with insufficient calories, athletes lost an average of roughly 4% of their body weight, about half of which was muscle mass. And they experienced a loss in performance:

"The fourteen days of insufficient food intakereduced their performance by 7.7% in a 20-minute time trial on a bike, which is quite significant. And during a more intense short-term test, their performance slid by as much as 18%. So there is no doubt that this practice greatly impairs one's performance as an athlete, even over shorter periods of time," says Jan Sommer Jeppesen.

In addition to sports performance, the researchers examined the effects on athletes' immune function:

"Among other things, we saw that insufficient energy intake was associated with increased systemic stress. The athletes had a large increase in cortisol, a stress hormone, and a dramatically increased stress level in immune cells. This suggests that there is a quite severe impact on several aspects of the immune system if one doesn't eat enough. This may potentially contribute to athletes being more exposed to illness," says Jeppesen.

The researchers hope that the results of the study will help create more awareness of the phenomenon:

"Many coaches continue to pressure athletes to lose weight. For many years, it has been a part of the culture in the sports world and remains so. We need to shed light on the phenomenon and ask critically: What are we actually doing to our athletes both physically and psychologically?" says Ylva Hellsten.

Team Denmark, the Danish elite sport organisation, welcomes the new research results with open arms.

"It focuses on a really important topic and challenges the attitude that lighter is always better. The theory and culture remains prevalent in many sports. I experience many athletes who trim their weight in the weeks leading up to a competition, but without understanding the consequences of doing so," says Majke Jrgensen, a sports nutritionist and manager at Team Denmark.

She sees the results as useful knowledge that can support a message that Team Denmark has been trying to promote:

"My experience is that elite athletes and coaches are curious, but need research that backs up any critiques of the phenomenon. Here, the fact that the test subjects are actual athletes is a major strength, so that the results can be transferred to the athletes and coaches that Team Denmark supports. We will use these results to support what we are already trying to communicate, both when we sit down with athletes one-on-one, as well as during workshops and presentations in these types of contexts," says Jrgensen.

After fourteen days of low energy availability (LEA), the athletes underwent a three-day "refeeding" period as part of the trial, during which they were provided plenty to eat.

"We had expected that the three days of enough food would restore their performance and maybe even improve it but there was absolutely no effect. Their performance was just as degraded as prior to the three days. This tells us that the negative effects cannot be reversed by quickly replenishing energy stores, which is a strategy used by many athletes," says Jeppesen.

According to the research literature, men tend to be more resilient when it comes to insufficient energy intake.

"Based upon the rather limited research in this area, it seems that men are able to tolerate reduced energy intake before it affects us negatively. This indicates that women in particular are a vulnerable population in this respect," says Jan Sommer Jeppesen.

The gender difference is partly due to the fact that low energy availability can cause a woman's estrogen levels to drop drastically. Since estrogen protects the circulatory system, muscles and bones, etc., estrogen loss has extensive effects on a woman's physiology. Ylva Hellsten points out that the harmful effects of not eating enough for long periods of time, especially in women, can therefore also be lifelong.

Source:

Journal reference:

Jeppesen, J. S., et al. (2024). Low energy availability increases immune cell formation of reactive oxygen species and impairs exercise performance in female endurance athletes.Redox Biology. doi.org/10.1016/j.redox.2024.103250.

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Drastic caloric restriction by athletes diminishes performance and compromises the immune system - News-Medical.Net


Jul 18

Khlo Kardashian reveals feelings about semaglutide, the famous weight loss injection – HOLA! USA

Khlo Kardashian, 40, opened up about her public weight loss journey, revealing her struggles and the methods she used to reshape her body. With honesty and a touch of humor, the reality star shared her thoughts on the trendy weight loss drug Ozempic and her newfound love for working out.

In a heartfelt confessional during "The Kardashians," Khlo expressed how exercise has become a vital part of her life for both physical and mental benefits. "Working out is something that makes me happy," she said. "To do something that is this authentic to me, something that I genuinely love, makes my heart so happy."

Despite her enthusiasm for fitness, Khlo acknowledged that it took time to discover this passion. She admitted that if the popular semaglutide brand had been available during her earlier struggles, she likely would have tried it. "When I was bigger, if they had Ozempic, I probably would have tried it cause I tried any other thing," she said, referencing the diabetes drug that has gained popularity as a weight loss tool.

Khlo has been candid about her past attempts to lose weight, including the notorious cayenne pepper and lemon juice diet. Reflecting on those times, she shared, "I tried any fad weight loss trend except for the real thing that actually works, and that's a lifestyle change." Her journey has led her to a healthier, more sustainable weight-loss approach. "So I really want to encourage healthiness, and not about the number on a scale. I just think people should be active," she emphasized. "I don't really care what your size is. You should just be healthy and stronger for yourself."

Today, Khlo relies on circuit training with cardio intervals to maintain her fitness. "I'm always spiking my heart rate up and down," she said, describing her routine. This approach not only keeps her in shape but also keeps her workouts exciting and challenging.

Khlo also revealed her strategy for preparing for photoshoots, where she knows she'll be showing a lot of skin. "For a shoot ... where I know I'm going to be showing a lot of skin, I definitely work out much harder," she admitted. However, she balances her hard work with a well-deserved treat. "I always celebrate with a full large pizza. Just cheese I'm a kid's menu type of girl," she said with a smile.

In May, she opened up about her fears regarding weight gain after welcoming her daughter, True Thompson, expressing concerns about returning to a state she once dreaded.

After giving birth, Khlo found herself at 204 pounds, which stirred memories of past insecurities. She confided in the SHE MD podcast, revealing her apprehensions about facing a journey she had navigated before. The prospect of regaining the weight she had worked so hard to shed was daunting, yet Khlo approached it with determination.

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Khlo Kardashian reveals feelings about semaglutide, the famous weight loss injection - HOLA! USA


Jul 18

90 Day Fiancs Darcey Silva Reveals Extraordinary Weight Loss Transformation In Rare Video With Daughter – Screen Rant

Summary

90 Day Fianc star Darcey Silva is revealing how she looks now after her 40-pound weight loss in a rare video with one of her daughters. Darcey is a 49-year-old mom of two from Connecticut who romanced much younger boyfriend Jesse Meester on Before the 90 Days. Since her split with Jesse, Darcey is now married to Bulgarian man, Georgi Rusev. Darcey is infamous among fans for constantly altering her look. Darceys many makeovers have made fans jaws drop, and now its time for Darceys remarkable weight loss to take centerstage. Darceys looking very different in a dance Reel.

Darcey Silva, whos appeared in multiple 90 Day Fianc spin-offs since her 2017 debut, has changed her lot over the past few years. In 2024, Darcey has lost more than 40 pounds.

Darcey doesnt usually appear in videos revealing her full body and even less in videos with her kids.

However, 90dayfianceupdate has reposted a video originally posted by Darceys daughter, Aniko Bollok, which shows her dancing with her mom and aunt Stacey Silva. The twins wore matching cowboy hats while dancing with Darcey opting for an all-black look with a sleeveless crop top and slim pants.

Reality TV is more popular than ever. With so many to choose from, here are some of the best reality TV shows to stream or watch right now.

Darcey was last seen in Darcey & Stacey season 4. The show didnt give a resolution to Darceys relationship with Georgi, but the duo announced that they had been married in November 2023. The couple has sparked split rumors multiple times since then but is back together for now. Their relationships ups and downs have entertained fans for four seasons now and fans wouldnt mind watching her again, especially to know her current relationship status with Georgi and to find out how Darcey lost weight.

Darcey has credited her weight loss to Ozempic and weight loss surgery. She often thanks her surgeon for making her look fit and slim in her photos. Darcey underwent an endoscopic sleeve gastroplasty (ESG) where the size of a persons stomach is reduced using stitches. Darcey has also recorded a video of her getting a shot of a weight loss drug which she said could help curb her appetite and make her lose weight. 90 Day Fianc spin-offs lately do follow weight loss surgeries of some cast members such as Angela Deem or Loren Brovarnik.

The same could happen in Darceys case if she shows up soon in a new season of Darcey & Stacey. Darceys sister Stacey and Staceys husband Florian Sukaj are rumored to appear in 90 Day: The Last Resort season 2. Darceys next move in the 90 Day Fianc franchise is unknown. Darcey is focusing on personal growth and getting healthier by losing weight. Shes perhaps letting her other cosmetic procedures take a back seat as she focuses on shedding her extra pounds and getting the curvaceous Barbie look shes always wanted.

90 Day Fianc: Happily Ever After airs Sundays at 8 p.m. EDT on TLC.

Source: 90dayfianceupdate/Instagram

90 Day Fianc is a reality TV series that follows the trials and tribulations of Non-U.S. citizens who travel from abroad each season to meet their potential spouses utilizing a K-1 visa. This three-month visa gives the pair 90 days to determine whether or not their romantic and life goals are aligned before they're forced to return home unmarried. Drama and tension unfold as the couples navigate the tricky dynamics of international marriage.

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90 Day Fiancs Darcey Silva Reveals Extraordinary Weight Loss Transformation In Rare Video With Daughter - Screen Rant


Jul 18

The next big thing in the weight loss drug boom has little to do with losing weight – Quartz

The next big thing in weight loss drugs isnt weight loss.

Wall Street Journal pharma reporter Peter Loftus made the case on Monday that the next wave of GLP-1 drug sales will be driven by the discovery of new medical uses for these slimming treatments.

Prime Day: The first half of Amazon's 48-hour sales event led to the biggest U.S. e-commerce day so far in 2024

The current market leaders of the GLP-1 space are Novo Nordisk, which produces Ozempic and Wegovy, and Eli Lilly, the maker of Mounjaro and Zepbound. GLP-1 drugs work by mimicking a gut hormone that regulates blood sugar and suppresses appetite. They were initially sold to treat Type 2 diabetes but their medical use has expanded to help combat obesity.

But with some health insurers still resistant to covering the treatments which can cost up to $1,300 a month solely for obesity, pharma companies are now testing these drugs for wider uses. Theyre being researched as possible treatments for heart, kidney, and liver diseases in effort to expand insurance coverage, and those efforts are starting to pay off.

The Food and Drug Administration expanded the approved use of Wegovy in March to include reducing heart risks for adults who are obese or overweight, allowing Medicare to cover the drug and opening access to Wegovy to about 3 million more Americans.

BMO Capital Markets analysts estimate that the new use of Wegovy for heart conditions will generate an additional $3.2 billion in annual sales for Novo Nordisk, Loftus reported.

In April, Eli Lilly announced that the drug behind Zepbound was found to help alleviate sleep apnea in patients with obesity in late-stage clinical trials. The pharma giant said its planning to seek approval from the FDA to expand the use of the drug to include treating the condition.

Jefferies analysts estimate this could increase sales for Zepbound by $5 billion.

It builds this wall of evidence, Derek Asay, senior vice president of value and access at Eli Lilly, told Loftus about trials looking at other uses for GLP-1 medications. It helps give that reason to believe theres more than weight loss here.

Unrelenting demand for for these drugs have transformed Novo Nordisk and Eli Lilly into the the largest pharma companies in the world, by market cap. Demand for these drugs has been so high that it has led to ongoing shortages and even boosted Denmarks GDP last year.

Morgan Stanley analysts anticipate the global market for these drugs will reach $105 billion by 2030.

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The next big thing in the weight loss drug boom has little to do with losing weight - Quartz


Jul 18

Richard Simmonss Radical Promise: Exercise Is for Everybody – The New York Times

If you lived in Los Angeles in the late 1970s, your choices for an aerobic workout class were truly slim. You could go to Jane Fondas studio in Beverly Hills, where everyone breaking a sweat was feather-to-lightweight, according to one observer. You could try a few dance studios where the professionally beautiful actresses, models, media personalities willed their bodies to become even more so. If building muscle was your goal, you could stop by Golds Gym or other palaces of pump, where an almost entirely male clientele strove for hard bodies in the image of Arnold Schwarzenegger.

It was against this backdrop of fitness exclusivity that Richard Simmons kicked, shouted and shimmied to the forefront of the workout scene, inviting the people he encountered to move with him first at his Los Angeles studio and then in their own living rooms, through his home workouts on TV and VHS.

With his trademark crown of frizzy hair, sequined tank tops, short-shorts and guy-next-door physique, Mr. Simmons, who died on Saturday at 76, did not look like a god, and he spoke to those who didnt aspire to look like a god, said Daniel Kunitz, the author of the book Lift: Fitness Culture, From Naked Greeks and Acrobats to Jazzercise and Ninja Warriors.

While other fitness evangelists promoted the idea that exercise was for every body, Mr. Simmons danced the dance, so to speak, and helped break down barriers for all sorts of people who didnt see themselves reflected in the fitness cultures of the time, Mr. Kunitz said.

And yet, despite his embrace of the overweight and overlooked, Mr. Simmons was singularly focused on helping his followers shed pounds, seemingly convinced that while you didnt need to aspire to look like a supermodel to be happy, losing weight was ultimately the key to health and well-being.

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Richard Simmonss Radical Promise: Exercise Is for Everybody - The New York Times



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