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Aug 31

7 Healthy And Natural Ways To Increase Testosterone – Longevity LIVE – Longevity LIVE

But the goal is never to eliminate stress. Youll only get more stressed if you try. Because guess what? The less stress you experience, the more stressful, less stressful things seem. Just as muscles grow with each workout, our bodies adapt to stressors and can deal with more of them.

But before you go out there and try to stress yourself out and bulk up your stress response, know this. How you respond to it impacts whether stress makes you stronger or weaker.

If you stress out, self-medicate and marinate in stress, it destroys your immune system and disrupts hormone production. But when you learn to manage it and let stuff go, your bodys ability to handle stress with a lesser stress response increases. So you need fewer stress hormones to deal with stress.

Vitamin D is, in fact, a hormone, not a vitamin. You produce it when exposed to sunlight. But you can also get it from mushrooms, eggs, supplements, and fortified products.

Vitamin D is critical for testosterone production, so you need to make sure youre getting enough of it to increase this vital hormone.

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7 Healthy And Natural Ways To Increase Testosterone - Longevity LIVE - Longevity LIVE


Aug 31

What men really need to know about low ‘T’ – fox13now.com

You may have seen ads targeting men with low testosterone or low T promising all kinds of benefits...but are they too good to be true?

Dr. Drew Oliveira, Senior Executive Medical Director for Regence BlueCross BlueShield says, The truth of it is, our testosterone gets lower as we age.

Oliveira says you may have heard that pills or supplements that can reverse this problem. And while there are some conditions that require testosterone replacement - contrary to advertisements, reduced vitality, strength and even demeanor or mood are not really a diagnostic for low testosterone.

Oliveira says to keep in mind that, Testosterone replacement has risks. A study of 15,000 older men men, showed a 21 percent increase in cardiovascular events in that group heart attacks, strokes. So, its not 100 percent safe to replace testosterone, especially in that population.

Instead, he suggests some other ways to stay healthy as you age.

First, if you smoke, stop smoking. Second, if you need to drink, limit your drinks to two drinks a day.

Alcohol use, Oliveira says, is associated with higher risks of cancer and cardiovascular risks, including hypertension.

Oliveira says you should also focus on diet and exercise to ensure healthy aging.

Maintain an ideal body weight. If youre overweight, even losing five percent will help. Eat healthy, what you eat should be very colorful, fruits, vegetables, grains, limit the amount of fats in your diet. All those things will help.

150 minutes of vigorous activity is also recommended each week.

If you do those things, you will feel better, you will feel younger, you will stay fit, you will live in optimum health, and you will live longer, says Oliveira.

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What men really need to know about low 'T' - fox13now.com


Aug 31

Sex steroid hormones are associated with mortality in COVID-19 patients: Level of sex hormones in severe COVID-19 – DocWire News

This article was originally published here

Medicine (Baltimore). 2021 Aug 27;100(34):e27072. doi: 10.1097/MD.0000000000027072.

ABSTRACT

In patients with coronavirus disease 2019 (COVID-19), men are more severely affected than women. Multiple studies suggest that androgens might play a role in this difference in disease severity. Our objective was to assess the association between sex hormone levels and mortality in patients with severe COVID-19.We selected patients from the Amsterdam University Medical Centers COVID-19 Biobank, in which patients admitted to hospital in March and April 2020, with reverse transcription-polymerase chain reaction proven severe acute respiratory syndrome-coronavirus-2 infection, were prospectively included. Specifically, we included postmenopausal women (>55 years) and age-matched men, with a mortality of 50% in each group. Residual plasma samples were used to measure testosterone, estradiol, sex hormone binding globulin (SHBG), and albumin. We investigated the association of the levels of these hormones with mortality in men and women.We included 16 women and 24 men in March and April 2020 of whom 7 (44%) and 13 (54%), respectively, died. Median age was 69 years (interquartile range [IQR] 64-75). In men, both total and free testosterone was significantly lower in deceased patients (median testosterone 0.8 nmol/L [IQR 0.4-1.9] in deceased patients vs 3.2 nmol/L [IQR 2.1-7.5] in survivors; P < .001, and median free testosterone 33.2 pmol/L [IQR 15.3-52.2] in deceased patients vs 90.3 pmol/L [IQR 49.1-209.7] in survivors; P = .002). SHBG levels were significantly lower in both men and women who died (18.5 nmol/L [IQR 11.3-24.3] in deceased patients vs 34.0 nmol/L [IQR 25.0-48.0] in survivors; P < .001). No difference in estradiol levels was found between deceased and surviving patients.Low SHBG levels were associated with mortality rate in patients with COVID-19, and low total and free testosterone levels were associated with mortality in men. The role of testosterone and SHBG and potential of hormone replacement therapy needs further exploration in COVID-19.

PMID:34449505 | DOI:10.1097/MD.0000000000027072

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Sex steroid hormones are associated with mortality in COVID-19 patients: Level of sex hormones in severe COVID-19 - DocWire News


Aug 31

Considering Male Hormone Replacement Therapy To Improve Health – Muncie Voice

To achieve optimal health, balanced hormones are required, no matter whether you are a man or a woman. Many men experience symptoms of weight gain, decreased motivation, low libido, depression, and tiredness as they start to get older and their testosterone levels lower. This is known as Andropause, which is commonly deemed male menopause. Going through these symptoms can easily make you feel down and stressed.

There are options available, and one solution to consider is what is known as male hormone replacement therapy. Below, we will reveal everything you need to know about it to get a much better understanding of what it is and what it entails.

The main benefit of male hormone replacement therapy is that it will help to lower and even reverse the symptoms associated with getting older. A lot of people have reported feeling more vigorous and younger after going through the treatment phase. However, all of the symptoms mentioned can cause a person to feel down and depressed, so male hormone replacement therapy helps make sure you enjoy life again.

When it comes to male hormone replacement therapy, otherwise known as testosterone replacement therapy, the man will be given testosterone. This is the hormone responsible for producing male characteristics, such as muscularity and facial hair, as well as the development of the male sex organs.

It is important to talk with a specialist at a clinic to determine whether or not male hormone replacement therapy is right for you. This is why the consultation phase is imperative. It will give them a full understanding of the condition you are experiencing and your medical history. This will enable the professional to come to the best decision on what will be right for you.

There are many different ways that you can go about male hormone replacement therapy. While some of the different methods do include injections, some do not require them at all. We will be able to talk you through some of the different available options. Aside from injections, some of the other choices include patches and testosterone gels.

Because of the rise of the Internet, there is a lot of misinformation out there nowadays. Recent research indicates that there is no link between prostate cancer and male hormone replacement therapy. In a study that was carried out whereby 1,500 patients were observed, it was deemed that higher testosterone levels may even help lower the risk of prostate cancer. Moreover, the risk of prostate cancer may increase if you have low testosterone levels, and therefore, there is no link between this type of cancer and Male Hormone Replacement Therapy.

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Considering Male Hormone Replacement Therapy To Improve Health - Muncie Voice


Aug 31

Over 60? Do These Exercises to Build Stronger Muscles, Say Experts | Eat This Not That – Eat This, Not That

Many older adults make the mistake of exercising less than they did when they were younger. But we should know better. In fact, you could make a strong case for exercising being even more important the older you get.

"When we are in our teens and 20s, building and maintaining muscle mass is as straightforward as it's ever going to be, explains Jack McNamara, M.Sc., C.S.C.S., of TrainFitness. "With the right exercise selection, training intensity, and nutrition, our muscles are primed to effectively increase in efficiency, size, and strength. But most people, especially those who don't have a history of lifting, will begin to lose muscle mass from their 30s onwards."

The medical term for what Bailey is describing is sarcopenia, or the gradual loss of muscle with age. You may not care all that much about cultivating a bodybuilder's physique after 60, but sarcopenia can lead to a steep decline in life quality. Balance suffers, bones and joints become weaker, and, before long, everyday tasks like simply climbing a flight of stairs can feel like a challenge. Just like taxes, sarcopenia is unavoidableat least to a certain extent.

"Muscle loss is a natural part of the aging process, but that doesn't mean you can't do something about it," says Josh Schlottman, C.S.C.S. For example, one study published in PLOS One found that a six-month resistance exercise training program "markedly reversed" the aging process among participants' muscles.

When we spoke to fitness experts about the best way for older adults to start building more muscle, a few recommendations kept coming up time and time again. To start, don't push yourself too hard. It's important to begin with exercises, weights, and routines that are right for your body and health.

Rachelle Reed, Ph.D., Senior Director of Health Science & Research for Orangetheory Fitness, recommends that older adults set SMART goals for themselves. "SMART stands for specific, measurable, attainable, relevant, and timely," she says. "As you begin a new exercise routine, remember to be kind to yourself and set reasonable goals. Rather than jumping in head-first, start slowly and in a way that feels manageable with your schedule."

But what about specific exercises?

We all know that muscles are built with weightlifting and resistance exercises first and foremost, but many of the trainers and physicians we spoke with say it's a mistake for those over 60 to focus too heavily on one specific muscle group. "I recommend reducing the total volume per muscle group you do per day and combining several muscle groups in one training session," says Dimitar Marinov, M.D., Ph.D. "This way, there is no risk to overtrain a single muscle group and injure yourself. Instead, you will do 1-2 exercises per muscle and train either half or all of your muscles in one workout. You can do that 2-3 times per week which will compensate for the decreased volume per session."

For the record, he's referring to compound exercises, and this approach is advantageous for older individuals for a few reasons. By spreading out the strain you'll reduce risk of injury while simultaneously targeting and building more muscles. Moreover, compound resistance exercises are also great for increasing testosterone levels, which is essential when it comes to building and maintaining more muscle.

Research published in the European Journal of Applied Physiology found that just one month of weight training increased testosterone levels among male participants by an average of 36%. Of course, women can also benefit from an uptick in testosterone when it comes to muscle maintenance and growth. "Hormones that impact our ability to build and maintain muscle, such as testosterone, drop by around 1% per year after 40. Performing compound moves stimulates the body to spike production of these hormones and ameliorate the decline as we age," Jack McNamara continues.

If you're ready to get started, read on to learn more about some of the best compound exercises for more muscle after 60. And for more reasons to exercise, don't miss this Secret Side Effect of Exercising More After 60, Says New Study.

Pull ups are an exercise classicand for good reason. They target the lats, delts, triceps, back, and core all at once using nothing but a bar to hold on to and your body weight. Even better, you can target different muscle areas depending on your grip. A close grip will focus more on your biceps and outer lats, while a wider grip will work your traps and inner lats more. And for some great exercise advice, don't miss the Secret Side Effects of Lifting Weights for the First Time, Says Science.

A diligent squatting routine can improve balance, posture, strengthen your core, improve bone density, and even help prevent dementia! Squats don't always come easy, and proper form is notoriously hard for even some experienced exercisers, but the leg muscle building benefits of this exercise makes it an essential part of any workout.

"This exercise is key to building muscle in the legs and lower body. For those over 60 with balance or coordination issues hold onto the back of a chair for balance. Stand with your feet hip width apart with your toes pointed straight ahead. Begin to lower your hips towards the floor by pushing them back behind you like you're going to take a seat. Try to get your legs to go down low enough so they're parallel to the floor. Keep breathing throughout the movement as you return back up to the starting position," Josh Schlottman suggests.

The rowing machine can be pretty intimidating for fitness beginners, but it's ideal for older adults looking to build muscle for a few reasons.

"One of the best exercises for building and maintaining muscle over age 60 is rowing," explains Caley Crawford, NASM-CPT, Director of Education for Row House. "People often associate rowing with cardio, but it is also a great strength-building exercise as it engages over 85% of the body's muscles. Rowing is low-impact and works 85 percent of the body's muscles, which means more bones are loaded and in turn, strengthened. Because rowing is done from a seated position and individuals are strapped into the footholds, there is no risk of falling during the exercise either. This helps offset the effects of bone resorption and conditions like osteoporosis. And unlike a spin bike or elliptical, the erg allows for full range of motion, promoting flexibility and joint health."

One study published in Biomedical Materials and Engineering even reports that rowing can help improve elbow, shoulder, and knee movements.

A regular bench press really only works the pectoral muscles, which is why an incline bench press is the superior choice for those over 60. By lifting at an incline of anywhere from 30-45 degrees (this will vary somewhat depending on your height and body type), you'll be working your entire upper chest, front deltoids, and triceps.

But, remember: Don't push yourself too hard with the weight. Start light and gradually build up your max rep over time. Also, your eyes should be directly under the bar when you sit down to begin. And for some more ways to motivate yourself to get to the gym, don't miss The Secret Tricks for Convincing Yourself to Exercise, Say Experts.

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Over 60? Do These Exercises to Build Stronger Muscles, Say Experts | Eat This Not That - Eat This, Not That


Aug 17

TRT for low testosterone: Options, cost, and side effects – Medical News Today

Testosterone plays a vital role in a range of bodily functions, including muscle and bone health, cognition, red blood cell and sperm formation, and sexual and reproductive function in males.

However, testosterone levels can decline for various reasons, including stress, aging, and certain health conditions, such as hypogonadism.

This article discusses TRT in more detail, including who it is for, the types, how it works, how to get it, what to expect from it, and more.

TRT or androgen replacement therapy (ART) is a treatment that doctors give to males who have testosterone deficiency and are showing symptoms of hypogonadism.

Taking prescription testosterone helps restore the levels of this hormone in the blood, reversing the symptoms of low testosterone. People who take it may notice improvements in alertness, sexual function, energy, mood, and overall well-being.

Doctors prescribe TRT to males with hypogonadism. To receive a definitive diagnosis, blood tests must show that a person has low testosterone levels, which the American Urological Association notes as being below 300 nanograms per deciliter (ng/dl). The individual must also have other symptoms, such as fatigue, breast growth, and sexual dysfunction.

However, doctors do not usually recommend TRT as the first course of action for low testosterone levels, even for males who show such symptoms.

If other conditions or medications cause testosterone levels to drop, doctors usually treat the underlying condition before recommending TRT.

TRT is only available with a prescription. If a person presents with symptoms consistent with low testosterone levels, a doctor will only provide a prescription after taking a thorough medical history and performing physical and lab exams.

As hormone levels fluctuate depending on activity levels, diet, and the time of day, doctors usually take a blood test before noon on 2 consecutive days. They may sometimes also ask for imaging studies and additional tests, such as tests for luteinizing hormone and follicle stimulation hormone, to determine the cause of the low testosterone levels.

There are several ways to administer testosterone:

Injectable testosterone is an inexpensive and common form of TRT. A person can receive short-acting treatment, which involves a shot every 1 or 2 weeks, or long-acting treatment, in which the second shot is 4 weeks after the first, and all others are 10 weeks apart. The dosage and frequency of the treatment may vary depending on the person.

Doctors inject short-acting testosterone under the skin or muscle, while long-acting shots go in the gluteal muscles.

TRT can cause fluctuations in testosterone levels, which can affect energy levels, libido, mood, and the presence of symptoms such as breast tenderness.

People usually apply gels and creams on a daily basis. Gradual absorption causes more stable testosterone levels in the blood.

However, people using topical treatments must be careful to avoid skin-on-skin contact with other people for at least 6 hours after application. It is important to prevent the risk of transferring the medication onto other peoples skin because it may be dangerous for pregnant people and children.

Topical patches stick to the skin and stay in place for 24 hours until the next dose. The downsides to patches are that they are not cosmetically appealing and often cause skin irritations.

A person places a buccal patch above the upper teeth, and it releases testosterone over 12 hours. In comparison with oral medications, patches may be less toxic to the liver. However, these patches can cause headaches and gum and mouth irritation.

Testosterone pellets are small plastic pellets that doctors implant under the skin. The implant goes into a persons upper hip or buttock. The pellets dissolve slowly and can deliver TRT for 36 months.

Inserting implants is a minor inpatient surgical procedure. A doctor makes a small cut and then inserts the pellets in the fatty tissue below the skin. They perform the procedure under local anesthesia.

Learn more about testosterone pellets here.

Oral testosterone is a less common type of TRT that is more expensive and less practical. Its long-term use can potentially cause liver damage.

Most tablets also come with warnings about the drug causing hypertension and stroke. As a result, only individuals who cannot use other forms of TRT resort to taking testosterone by mouth.

A person applies nasal testosterone gel to the inside of the nose. They will need to do this three times a day at intervals of 68 hours, preferably at the same times every day. Some common reactions to this treatment include headaches, nosebleeds, a runny nose, and nasal discomfort.

TRT aims to restore a persons testosterone levels to normal. The individual can expect improvements in their blood testosterone levels within a week.

A person may also note other benefits, such as an increase in bone density and lean body mass, an improvement in well-being, and a boost to energy and libido. It may take from 4 weeks to several months to see positive changes.

TRT is typically a lifelong treatment. Once a person starts TRT, their doctor will continually monitor their response to treatment. People need to have routine checkups at least every 612 months to assess their blood testosterone levels.

A doctor will also monitor changes in symptoms and side effects at 3 and 6 months after the initial treatment and then annually.

TRT costs range from $150 to $1,500 per month and vary depending on various factors, including:

In addition to the possible short-term side effects, TRT may also cause health risks. The Endocrine Society recommends that people with the following conditions do not start using TRT:

It also states that the treatment is unsuitable for males who wish to conceive in the near future.

Males aged 40 years older, preadolescent people, and those with migraine or epilepsy may require special considerations.

The Food and Drug Administration (FDA) explains that the benefits and safety of TRT for treating low testosterone levels due to aging are not known. The organization requires that testosterone products carry warnings mentioning the possible risk of stroke and heart disease.

A 2017 review found that men undergoing TRT have a higher risk for cardiovascular events such as stroke.

Other side effects of taking testosterone include:

High cholesterol may also be a side effect. However, a 2021 study suggests that TRT may improve total cholesterol levels.

The current scientific literature suggests that TRT worsens breast and prostate cancer. However, TRT may offer benefits to people with early stage prostate cancer without stimulating the recurrence or progression of cancer.

The following are commonly asked questions:

TRT costs range from $150$1,500 per month depending on the type of TRT, the mode and frequency of administration, and the insurance coverage.

Yes. Most insurance companies cover all forms of TRT. However, there may be out-of-pocket costs.

Although TRT offers benefits to people with low testosterone levels, it can cause many short-term side effects. It may also put people who take TRT in the long term at increased risk of liver and heart problems.

TRT treatment length is indefinite unless the low levels are due to an underlying cause that is treatable.

TRT is a common treatment for low testosterone levels, but it is not suitable for everyone.

People who are considering TRT need a prescription and proper guidance from a doctor.

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TRT for low testosterone: Options, cost, and side effects - Medical News Today


Aug 17

Optimizing the Diagnostic Accuracy and Treatment Decisions in Men with Testosterone Deficiency – DocWire News

This article was originally published here

Endocr Pract. 2021 Aug 11:S1530-891X(21)01158-7. doi: 10.1016/j.eprac.2021.08.002. Online ahead of print.

ABSTRACT

OBJECTIVE: This narrative review offers a guideline-based approach to optimizing the diagnostic evaluation and treatment decision-making in men being evaluated for testosterone deficiency.

METHODS: A narrative review RESULTS: Testosterone deficiency is a clinical syndrome that results from the inability of the testes to produce normal amounts of testosterone, and is characterized by a constellation of symptoms and signs associated with consistently low testosterone concentrations. The diagnosis of testosterone deficiency is made by ascertainment of symptoms and signs; measurement of total and, if indicated, free testosterone levels, in early morning fasting samples on 2 or more days; measurement of LH and FSH to distinguish primary from secondary hypogonadism; and additional evaluation to ascertain the cause of testosterone deficiency. Non-specificity of symptoms and signs; variations in testosterone levels over time; inaccuracy in the measurement of total and free testosterone levels; variations in binding protein concentrations; and the suboptimal reference ranges contribute to diagnostic inaccuracy. Testosterone treatment is indicated for men with symptomatic testosterone deficiency. Testosterone treatment should be avoided in men with prostate or breast cancer, erythrocytosis, thrombophilia, increased risk of prostate cancer or severe lower urinary tract symptoms without prior urological evaluation, recent major adverse cardiovascular event, uncontrolled heart failure or severe untreated sleep apnea. Testosterone replacement therapy should be accompanied by a standardized monitoring plan.

CONCLUSION: The shared decision to treat should be guided by consideration of the burden of symptoms, potential benefits and risks, patients values, and the cost and burden of long-term treatment and monitoring.

PMID:34390882 | DOI:10.1016/j.eprac.2021.08.002

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Optimizing the Diagnostic Accuracy and Treatment Decisions in Men with Testosterone Deficiency - DocWire News


Aug 17

Keenan: Is your success tied to your testosterone? – Calgary Herald

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Over the years, many physical traits have been touted as correlated with male success. Tall guys make more money. Attractive men have a better chance of getting hired. Obese fellows suffer in job interviews.

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That height/income correlation is pretty well documented. University of Florida researcher Timothy Judge and colleagues analyzed data from 8,500 American and British subjects and worked out that someone who is six feet tall earns, on average $166,000 more in a 30-year career than someone who is 5 feet 5 inches. This was true for both genders, though shorter men are slightly more likely to encounter height bias in the workplace than are shorter women.

Likewise, the attractiveness bias, sometimes called lookism, is well established. A 2019 article in the Harvard Business Review noted that it starts early. Attractive applicants score higher in college admissions interviews and earn higher grades when they get to class. The author, business psychology professor Tomas Chamorro-Premuzic, cites the very well-established halo effect whereby attractive people are generally perceived as being more sociable, healthy, successful, honest, and talented.

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He also makes an interesting suggestion for tackling this type of bias artificial intelligence. If programmed correctly, he writes, AI could become an objective way to measure what we dont always see ourselves. The key phrase there is if programmed correctly. So far, many artificial intelligence models simply automate the biases of their creators.

Testosterone certainly appears to predict some kinds of business success. Researchers led by Sean Harrison of the University of Bristol note that among male executives, circulating testosterone has been linked with a number of subordinates and among male financial traders, with daily profits.

It has been suggested that this happens because higher testosterone levels tend to increase a mans tolerance for risk. This, in turn, leads many guys with high testosterone to choose the path of entrepreneurship, with the attendant risks and rewards. Even for those in standard employment situations, a higher testosterone level may affect willingness to engage in assertive wage bargaining.

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Harrison and colleagues dove into a huge biomedical database, the U.K. Biobank, and studied the records of 306,248 men and women. They were seeking to establish a causal relationship between testosterone levels and what they called socioeconomic position (SEP).

One concern here is the direction of causation. Perhaps having a lower SEP causes lower testosterone levels in men. This would make sense because being poor is stressful and, as they note, psychosocial stress associated with socioeconomic adversity could influence testosterone alongside other aspects of health.

One unique contribution of this study is the fact that it used a technique called Mendelian Randomization. Made possible by advances in genetics, this method analyzes single nucleotide polymorphisms (SNPs) which are determined at conception and related to a single factor, in this case, testosterone production. This allows the researchers to rule out reverse causation and other confounding effects.

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At the end of the day, they concluded that We found little evidence that testosterone affected socioeconomic position, health, or risk-taking. Were previous studies wrong? Not necessarily, but they may have been clouded by reverse causation or other factors.

Another study, also from the U.K., compared men who grew up in the relatively healthy and wealthy environment of London with those raised in Sylhet, Bangladesh. As the authors note, Men in wealthier countries tend to have higher levels of testosterone than men in poorer countries or places with high rates of infectious disease.

What wasnt clear is when this effect took place. Was it in infancy? Childhood? After puberty? New research by Kesson Magid of Durham University studied men who moved to London at various life stages. The researchers looked at factors like height, age of puberty, and testosterone levels as adults.

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Migration before puberty predicted higher testosterone and an earlier recalled pubertal age compared with Bangladeshi sedentees or adult migrants, with more pronounced differences in men who arrived before the age of eight.

They have an interesting explanation for their results, which is based on the energy cost of various activities. Boys in Bangladesh, where sanitation is poor, spend a lot of their biological resources developing immunity. This comes at the expense of building a strong reproductive function.

As the authors write, We found that the longer a man lived in Bangladesh as a child, the shorter he was as an adult. This suggests that boys growing up in Bangladesh had to trade off growing taller for something else, such as immunity.

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Theres not much you can do about your height or attractiveness unless you are ready for serious plastic surgery. As for tweaking your testosterone levels, experts like urologist Dr. Puneet Masson of the University of Pennsylvania urge caution. He treats men with low testosterone levels who are trying to become fathers. Many times Im taking these guys off of supplements or medications and putting them on something to get their body to make its own testosterone, he notes. The Penn Medicine site also cautions that taking exogenous or external testosterone shuts off other hormones essential for sperm development.

Its worth a mention that these testosterone studies were published both in academic journals and, in a more approachable format, on a free website called theconversation.com/ca. Spending some time reading articles there might have an even stronger correlation with your career success than your height, looks, or testosterone levels.

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Keenan: Is your success tied to your testosterone? - Calgary Herald


Aug 17

Decreased testosterone recovery after androgen deprivation therapy for prostate cancer – DocWire News

This article was originally published here

Can J Urol. 2021 Aug;28(4):10738-10742.

ABSTRACT

INTRODUCTION Androgen deprivation therapy (ADT) is often used in the treatment of prostate cancer. Specific factors affecting testosterone recovery after cessation of ADT have not been well-characterized in existing literature.

MATERIALS AND METHODS: We retrospectively reviewed patients at our institution who received ADT between 1999 and 2018. Patients with at least one course of ADT and subsequent testosterone level within 12 months of cessation of ADT were included. Patients received at least one of the following four agents: leuprolide, goserelin, triptorelin, and degarelix. Cox regression models were utilized to estimate the effect of patient and treatment characteristics on time to testosterone recovery( 240 ng/dL) after ADT cessation. Patients without testosterone recovery were censored at last testosterone evaluation. To account for the possible dependency between multiple ADT courses within a patient, we used a robust sandwich variance estimate.

RESULTS: Severty-six patients were included. Mean age was 64 +/- 8 years. Median duration of ADT was 15 months, with a median time to recovery of 19 months. On univariable analysis, age and duration of ADT were significant; a trend towards significance was noted for hypertension, diabetes, peripheral vascular disease, goserelin and bicalutamide. Patient age, duration of ADT, and treatment with the agent goserelin were significantly associated with prolonged hypogonadism on multivariable analysis (p < 0.01).

CONCLUSIONS: Increasing age and duration of ADT therapy are associated with decreased likelihood to recover normal testosterone levels after cessation of therapy. The use of the ADT agent goserelin was also associated with decreased testosterone recovery for unclear reasons.

PMID:34378507

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Decreased testosterone recovery after androgen deprivation therapy for prostate cancer - DocWire News


Aug 17

Katie Compton’s Positive Steroid Test and Ban: Here’s What We Know – Cyclocross Magazine

Cyclocross fans were shocked by the news of Katie Comptons four-year USADA ban for anti-doping violations. Reports of different tests, isotopes, ratios, biological passports and terms like anabolic androgenic steroids had most of us turning to Google, or turning away in confusion.

Bruce Hildenbrand has covered professional cycling for four decades, and in that timeframe, he has developed more than a laymans knowledge of the unfortunate, darker side of the sport. He offers Cyclocross Magazine readers his insight and some background on the recent events that surround Comptons positive test and subsequent four-year USADA ban.

The stunning news that Katie Compton received a four-year doping ban for an anabolic androgenic steroid raised more questions than answers. Given that the Carbon Isotope Ratio (CIR) test was used to re-analyze her urine sample, it likely indicates that the anabolic androgenic steroid was testosterone.

Katie Comptons husband, Mark Legg-Compton, has since confirmed the substance was exogenous testosterone in a Facebook post.

It is well known that testosterone aids in recovery. Top professional road riders including Floyd Landis and Tom Danielson have been busted for testosterone by the CIR test, but it is not used very frequently by anti-doping laboratories.

This new finding brings the whole problem of the current form of testosterone testing to the forefront. For years, the testosterone-to-epitestosterone ratio test, known a the T/E Ratio test, has been used to determine if an athlete is taking an external source of testosterone.

Unfortunately, if an athlete is using a water-soluble version of testosterone and they take it during the late evening/early morning windows when athletes are not typically tested, it is very easy to beat the T/E Ratio test. This is the reason why the CIR test was developed. Using a gas chromatograph and mass spectrometer, the test can accurately detect the different carbon isotopes which occur between naturally occurring testosterone, which the human body produces in the gonads for men and ovaries for women, and the plant-based testosterone which is the form taken externally.

Why continue to use a flawed test? The reason why the T/E Ratio test is still being endorsed and used by the World Anti-Doping Agency (WADA) accredited anti-doping labs is that it costs about $30 per test whereas the CIR test costs about $300 per test.

In the sport of cycling, in-competition dope testing is typically paid for by the race, whereas the anti-doping agencies, such as USADA, pay for out-of-competition testing. Unfortunately, it just comes down to a matter of economics and not which test is the most accurate. However, as weve seen with samples from the last few Olympic Games, athletes samples, which are stored just for this purpose, are being re-tested. This can happen when new tests are developed, or in the case here with Katie Compton, when her biological passport indicated that her sample might need additional testing, USADA can use the more accurate CIR test.

So, what does this mean for Katie Compton? Recent changes to the WADA code require a four-year ban for the first doping offense. Clearly, the anti-doping authorities believe the results of their tests. The only avenue for Katie is to either challenge the handling of her sample or how her tests were performed, or perhaps prove it was unintentional and get a reduced sentence. Such a challenge is expensive and can cost hundreds of thousands of dollars. Some athletes in the early stages of their careers have chosen just to sit out the ban. Being near the end of her career, Katie chose to retire.

Bruce Hildenbrand has been covering the sport of professional cycling in the US and Europe for over 40 years. He has reported on numerous doping cases for major media outlets such as Outside Magazine.

What will fans focus on in remembering Comptons career given the recent news? photo: 2018 Superprestige Gavere Women. A. Yee / Cyclocross Magazine

Original post:
Katie Compton's Positive Steroid Test and Ban: Here's What We Know - Cyclocross Magazine



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