Search Weight Loss Topics:


Page 11234..1020..»


Jun 13

Does Masturbation Decrease Testosterone? Here’s What Sexual Health Experts Say – The Healthy

Testosterone is the key hormone responsible for developing male sex characteristics, such as facial hair and a deeper voice, and it plays a pivotal role in muscle mass and sexual function in both men and women.

Over the past few decades, research has shown a subtle yet steady decline in testosterone levels among men, a trend documented since the 1980s and highlighted by a 2021 study in the peer-reviewed journal European Urology Focus. This study, which analyzed testosterone levels in adolescent and young adult men from a U.S. national database, revealed a consistent drop in average total testosterone over the past 20 yearsa decline that correlates with rising body mass index. Despite this trend, testosterone levels have not yet dipped to clinically low ranges across the population, but they are inching closer to that point each year.

So, whats driving this downward trend? While some factors are beyond individual control, lifestyle choices significantly contribute. Conditions like diabetes and obesity are closely linked to lower testosterone levels. Data show that another increasingly common concern seems to be whether sexual activities like masturbation and ejaculation decrease testosterone levels and lead to hormonal imbalances in males. In short, research in this area does not support the idea that these activities impact testosterone levels over the longterm.

Keep reading for more, as researchers and experts Lawrence Hawkim, MD, a board-certified urologist at the Cleveland Clinic, Kevin Pantalone, DO, a board-certified endocrinologist at the Cleveland Clinic, and Jessica Shepherd, MD, MBA, FACOG, board-certified OB/GYN and thought leader on menopause, speak to the science between masturbation and testosterone levels.

Get The Healthy byReaders Digestnewsletter

While masturbation does influence testosterone, it does not decrease these levels, according to Cleveland Clinic urologist Dr. Hawkim. He says masturbation neither triggers hypogonadism (low testosterone or low T) nor impacts long-term testosterone levels. However, Dr. Hawkim says, its short-term effects are still under investigation.

Researchers in Germany, focusing on molecular and cellular sports medicine and cardiovascular research, also investigated this subject. Their 2021 study, published in the peer-reviewed journal Basic and Clinical Andrology, suggests that masturbating before strength training could actually lead to a temporary boost in testosterone levels, aiding in muscle growth. Further studies are necessary to solidify these findings.

Testosterone is also essential for females, particularly postmenopausal women. Dr. Shepherd explains that reductions in testosterone, along with decreases in estrogen and progesterone during menopause, impact the physical response as well as the psychological response surrounding sexual activity. Maintaining a healthy lifestyle and considering hormone supplementation can be important for women during this transition.

An article published in The Journal of Sexual Medicine in 2021 found that higher testosterone levels in women are associated with increased libido and more frequent masturbation or sexual activity, and, like in men, the long-term effects of masturbation on testosterone levels appear negligible.

Although further research is necessary to fully understand the specific effects of various sexual activities like masturbation on testosterone levels, current scientific evidence and expert consensus indicate that masturbation does not cause a long-term decrease in testosterone levels.

According to the American Urology Association (AUA), low blood testosterone is defined as levels below 300 nanograms per deciliter (ng/dL). Dr. Hakim notes that anything that negatively affects overall health can diminish testosterone levels.

Here are several factors that commonly lead to decreased testosterone:

Low T can present through various symptoms. Here are some typical signs to be aware of:

Boosting your testosterone is largely about embracing a healthier lifestyle.

Dr. Pantalone explains, Its normal for a person to experience a drop in testosterone as they age, but were seeing that process accelerated in more recent times because of poor overall health.

Here are some effective strategies to enhance your hormonal health:

Exercise more: Regular physical activity, especially strength training and high-intensity interval training, can boost testosterone levels.

Eat healthy: Focus on a balanced diet rich in proteins, healthy fats, and whole grains. Foods like eggs, leafy greens, and fatty fish are particularly beneficial. Avoid excess alcohol, smoking, and substance use.

Get quality sleep and manage stress: Aim for 7-9 hours of sleep per night and explore stress reduction techniques such as meditation, yoga, or deep breathing exercises.

If youre concerned about your testosterone levels or are experiencing symptoms such as fatigue or low libido, consult your healthcare provider. They can perform tests to determine the cause, which may be linked to low testosterone or another health issue. They can also discuss if you need testosterone replacement therapy if levels are significantly low due to medical conditions.

For more wellness updates, subscribe to The Healthy by Readers Digest newsletter and follow The Healthy on Facebook and Instagram. Keep reading:

Read more from the original source:
Does Masturbation Decrease Testosterone? Here's What Sexual Health Experts Say - The Healthy


Jun 4

Trial finds male birth control gel safe and effective – WXYZ 7 Action News Detroit

(WXYZ) Scientists report promising results for an innovative form of birth control for men.

This hormonal gel has been shown to effectively reduce sperm production in clinical trials.

This potential birth control for men contains testosterone and Nestorone. Nestorone is a synthetic progestin, a type of hormone used in contraceptive methods. The results from the phase-two trial showed that the gel successfully decreased sperm production in men.

Now, a total of 222 men took part in this study all between the ages of 18 and 50. Every day, they applied about a teaspoon of the gel to each shoulder blade.

Researchers monitored their sperm production every four weeks. By the 12th week, 86% of the men experienced a decrease in sperm count, making pregnancy unlikely.

On average, effective contraception was achieved within eight weeks, which was faster than previous methods tested.

Also, participants maintained testosterone levels that did not affect their sex drive, and no adverse side effects were reported. The second phase of the study is still in progress, with researchers monitoring the effectiveness of the gel in preventing pregnancy.

A phase-3 trial for this potential male contraception gel is still needed. On average, it costs $1 billion to $2 billion to get a drug to market. For this product, funding from a partner like a major pharmaceutical company is essential. But so far, none have stepped up.

As for non-hormonal options, a San Francisco-based biopharmaceutical company called YourChoice Therapeutics found its non-hormonal pill safe in a small UK trial with 16 men. The pill works by blocking a vitamin A receptor thats needed for male fertility. The company is now planning a much larger study.

Also, a Virginia medical device company called Contraline is testing its non-hormonal male birth control method. It involves a 15-minute procedure where a gel is injected into the tubes that carry sperm from the testicles. An early trial in Australia showed a 99.8% to 100% reduction in motile sperm within 30 days for 25 participants. Contraline aims to start trials in the U.S. in 2025.

I support male contraception because it would give men greater control over their reproductive health and help them share the responsibility of preventing pregnancies. It would also provide more birth control options, especially for women who arent able to use hormonal methods due to side effects or medical reasons.

Go here to read the rest:
Trial finds male birth control gel safe and effective - WXYZ 7 Action News Detroit


Jun 4

Novel male contraceptive gel suppresses sperm production faster than similar birth control methods – News-Medical.Net

A novel male contraceptive gel combining two hormones, segesterone acetate (named Nestorone) and testosterone, suppresses sperm production faster than similar experimental hormone-based methods for male birth control, according to a new study.

Results from an ongoing multicenter phase 2b clinical trial will be presented Sunday at ENDO 2024, the Endocrine Society's annual meeting in Boston.

The development of a safe, highly effective and reliably reversible contraceptive method for men is an unmet need. While studies have shown that some hormonal agents may be effective for male contraception, the slow onset of spermatogenic suppression is a limitation."

Diana Blithe, Ph.D., senior researcher, chief of the Contraceptive Development Program at the National Institutes of Health (NIH) in Bethesda, Md.

NIH'sEunice Kennedy ShriverNational Institute of Child Health and Human Development is funding the study, which included 222 men who completed at least 3 weeks of daily treatment with the contraceptive gel. The gel contained 8 milligrams (mg) of segesterone acetate and 74 mg of testosterone. Segesterone acetate is an ingredient of the Annovera vaginal birth control ring. Men applied the gel once daily to each shoulder blade.

Early in the study, the researchers measured for suppression of sperm production by obtaining sperm count tests at 4-week intervals. The threshold deemed effective for contraception was 1 million or fewer sperm per milliliter of semen, Blithe noted.

Most study participants (86%) reached this sperm count by week 15, the researchers reported. Among those men, sperm production was suppressed at a median, or midpoint, time of less than 8 weeks of segesterone-testosterone treatment. Blithe said prior studies of male hormonal contraceptives given by injections showed a median time between 9 and 15 weeks for sperm output to become suppressed.

"A more rapid time to suppression may increase the attractiveness and acceptability of this drug to potential users," Blithe said.

Testosterone treatment alone decreases sperm production, with a median time of 15 weeks but the addition of segesterone acetate speeds the time and lowers the dose of testosterone needed to suppress sperm production over testosterone alone, she said. In the daily segesterone-testosterone gel regimen, blood levels of testosterone are kept in the physiologic range to maintain normal sexual function and other androgen-dependent activities.

The sperm suppression stage of the international phase 2b trial of segesterone-testosterone gel is complete. The study continues to test the contraceptive's effectiveness, safety, acceptability and reversibility of contraception after treatment stops.

Read more here:
Novel male contraceptive gel suppresses sperm production faster than similar birth control methods - News-Medical.Net


Jun 4

Understanding the long-term effects and safety of testosterone therapy in transgender men – News-Medical.Net

Transgender individuals often face unique challenges in aligning their physical bodies with their true gender identity. Among the various methods employed, gender-affirming hormone therapy (GAHT) stands as a vital means for transgender men to achieve physical changes in consonance with their gender identity. Navigating the complexities that come with gender transition, transgender individuals seek medical interventions to alleviate gender dysphoria and align their bodies with their gender identity.

For transgender men, testosterone therapy holds promise in inducing masculinizing effects such as increased muscle mass, cessation of menstruation, and deepening of the voice. However, the lack of comprehensive research on the long-term effects and safety of testosterone therapy poses significant challenges in clinical decision-making and underscores the persistent taboo surrounding transgender healthcare. To address this pressing need, a study led by Assistant Professor Yusuke Tominaga along with Dr. Tomoko Kobayashi and Dr. Motoo Araki from the Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan dives into understanding the long-term physical effects and safety profile of testosterone therapy for transgender men, shedding light on crucial aspects of hormone administration and its impact on body composition. Their research findings were published in Andrology on 2 April 2024.

"The research team was inspired to investigate this area as we noticed the lack of a standardized regimen for testosterone dosage and administration. Our aim was to understand how hormone dosages are adjusted to align more closely with typical male testosterone levels in the bloodstream," explains Dr. Tominaga.

Analyzing data from transgender men who commenced GAHT between May 2000 and December 2021, the researchers meticulously recorded physical findings, blood test results, and menstrual cessation rates. They then compared the effects of testosterone on body composition changes and laboratory parameters, stratifying participants into low-dose and high-dose groups based on their testosterone dosage.

The findings of the study revealed that both low-dose and high-dose testosterone regimens demonstrated favorable outcomes, with no significant differences observed in menstrual cessation rates up to 12 months. Over time, participants exhibited a decrease in body fat percentage and an increase in lean body mass, indicative of the desired masculinizing effects of testosterone therapy.

Notably, the high-dose group exhibited greater gains in lean body mass during the initial year of therapy, suggesting a potential strategy for individuals seeking more rapid changes in body composition. Importantly, the study found no evidence of long-term, dose-dependent side effects such as polycythemia or dyslipidemia, reassuring both clinicians and transgender individuals regarding the safety profile of testosterone therapy.

Reflecting on the significance of their findings, Dr. Tominaga explains, "Our study contributes valuable evidence on the long-term effects of testosterone therapy, providing crucial insights for clinicians managing transgender healthcare. By elucidating the safety and efficacy of hormone therapy, we hope to alleviate uncertainties surrounding transgender healthcare and empower individuals to make informed decisions about their treatment."

This study opens the door to more inclusive and evidence-based care by illuminating the long-term effects and safety of testosterone therapy for transgender men.

Source:

Journal reference:

Tominaga, Y., et al. (2024). Trans men can achieve adequate muscular development through lowdose testosterone therapy: A longterm study on body composition changes.Andrology. doi.org/10.1111/andr.13640.

See original here:
Understanding the long-term effects and safety of testosterone therapy in transgender men - News-Medical.Net


Jun 4

With his transgender identity public, skier Jay Riccomini finds success on and off the slopes – The Daily Gazette

It was a breakthrough performance and the announcer used his correct pronouns.

I just thought, It took some time to get there. But we did it,'" he said.

On July 20, 2021, Riccomini, then 17, announced on social media that he was a gay transgender man who would from then on use the pronouns he and him. I want the world to know who I am and who Im meant to be so I can pursue it openly, he wrote.

Now 20, he is on top of the world: In January, he placed third at a World Cup slopestyle competition, an event that features skiers spinning and flipping down a mountain slope filled with rails, bumps and jumps. He also finished third in two other events last season, giving him a third-place finish in the overall slopestyle standings. He was recently promoted to the U.S. Freeski pro team. And he's being mentioned as an Olympic hopeful for the 2026 Milan-Cortina Winter Games.

As part of his transition, Riccomini underwent top surgery more than a year ago to create a masculine appearance. But he has decided to put off taking testosterone until his career is over, to stay in compliance with the regulations. He still competes in womens events, and will continue to do so if he makes the Team USA roster for the Olympics.

Riccomini says he has received nothing but support from the freestyle skiing world since he announced he was trans.

I thought I was going to have to give up my hopes and dreams, he said. People rose above my expectations, for sure.

But he also acknowledges that the road to becoming Jay Riccomini was neither smooth nor straightforward.

Its not a linear line. Its a freaking roller coaster through it all, he told The Associated Press recently, in one of his first interviews with a national news outlet.

From a young age, even before he realized what it was, Riccomini began experiencing gender dysphoria, when a persons gender identity doesnt match their sex assigned at birth. But he kept it secret.

The mountains provided both a refuge and an escape. Growing up in Port Matilda, Pennsylvania, he spent many winter weekends with his brother at Tussey Mountain, which featured a terrain park loaded with jumps and rails.

On numerous occasions, his family also traveled to Copper Mountain, Colorado, where coaches at Woodward, a training ground for kids interested in action sports, recognized his talent.

But not being able to share his secret weighed heavily on him, and ultimately led to such a severe depression that even the mountains couldnt save him. His parents didnt know the depths of his struggles, either.

I just wanted Jay to be happy, and Jay was unhappy for so many years, said his mother, Andrea. Thats been the hardest part for me, that he was unhappy for so long."

Rock bottom came at 17, while Riccomini attended a winter sports school in Park City, Utah. He missed classes. His grades suffered. And in perhaps the most worrisome sign that something was wrong, he was often absent from the terrain park, one of his favorite spots.

When people saw that I wasnt there, theyre like, Where are you? Riccomini recounted. I was depressed. I wasnt eating. It wasnt good.

Even when he had a memorable moment finishing 18th in his World Cup debut in Aspen in March 2021 he wasn't able to truly celebrate. It was under his old name. Every time someone referred to him as her, it gave him anxiety.

I just felt like I was going to throw up, he said.

He decided to take action.

First, he told a close friend he was trans. Then, he changed his pronouns on his Instagram bio to they/them and told more teammates and friends. Not long afterward, while out skiing, he came up with a new name.

I was like, Should I call myself Jake or Jack or Ace? he said. I thought, Jay Jay is perfect. Its just easy" and it happened to echo his father's middle initial, J.

Teammate Colby Stevenson began calling him Jay-Bird.

I like that, Riccomini said. I really like that.

With his name in place, Riccomini went public on Instagram, writing that he was "over constantly feeling trapped in my own body."

The announcement set him free, transforming his anxiety into hope and happiness.

Seeing him happy, his mom said, "is priceless.

At a World Cup event in February 2023, the International Ski Federation used Jay Riccomini's new name in its results for the first time.

It is our duty to do everything within our reach to ensure he feels included and respected in our competitions, the federation's integrity director, Sarah Fussek, said in a written statement to AP. "As the institution that represents snow sports around the whole world, for all, we have a moral obligation to do so.

U.S. Ski & Snowboard has also expressed its support.

"His dedication to the sport has resulted in a number of podiums at a young age, Sophie Goldschmidt, president and CEO of USSS, said in a statement. We know that he will continue his success on the world stage throughout the upcoming years.

Riccominis mission now is to open doors for other transgender athletes and to inspire them the way he has been motivated by others.

This young athlete has fought for and has earned with his results the right to be seen, said Rook Campbell, a trans athlete and professor in areas of advertising, sports, globalization and media at the University of Southern California. Visibility is powerful.

As difficult as his own journey has been, Riccomini knows it is even harder for transgender women. After swimmer Lia Thomas became the first openly transgender athlete to win an NCAA Division I national championship, World Aquatics effectively banned transgender women from competing in womens events. World Athletics, the governing body for track and field, has done the same.

Transgender girls are also banned from competing in girls sports at the high school level in numerous Republican-led U.S. states, where some lawmakers argue that they have an unfair strength advantage over cisgender girls. People on both sides point to limited research to back their opinions.

Thomas is someone Riccomini looks up to he even wrote a paper about her experience for a civics class.

I cant imagine the toll taken on her mental health, Riccomini said. Shes just amazing.

Campbell said it is sometimes easier for transgender men to speak out and gain acceptance than it is for transgender women. He said he thinks it's great to use that privilege.

I just wish it was broader, he said.

As happy as he is, Riccomini realizes his transition won't be fully complete until he can take testosterone, something he knows will help ease his gender dysphoria. But for now, just being recognized publicly as Jay is good enough.

When people call me he, I get this warm feeling in my stomach, he said. This overwhelming wave of happiness that flows through my body, knowing everyone sees me now for who I am.

AP Winter Olympics: https://apnews.com/hub/winter-olympicsAP

Read the rest here:
With his transgender identity public, skier Jay Riccomini finds success on and off the slopes - The Daily Gazette


Jun 4

Tolmar Announces Results From Inaugural Landmark Survey of US Physicians To Assess Current State of … – PR Newswire

BUFFALO GROVE, Ill., June 2, 2024 /PRNewswire/ -- Tolmar Inc., a fully integrated pharmaceutical company, today announced results from a landmark survey of more than 300 US physicians, revealing barriers to treatment with testosterone-replacement therapy (TRT) among patients and physicians that, if addressed, may improve patient care.Detailed results of the survey will be presented at ENDO 2024, the signature annual meeting in endocrinology, in Boston on Sunday, June 2.The survey was conducted in partnership with the leading online physician community, Sermo.

"Men living with a testosterone deficiency have more treatment options than ever, but this expanded range of choices can be confusing. A key finding in the survey is that 66% of men on TRT switched therapy in the last year in order to find a form of therapy that works best for them. Not surprisingly, much of this is driven by insurance, but there is also a lack of awareness of newer and safe treatment options, like oral therapy, that may improve patient care," saidSandeep Dhindsa, M.B.B.S., Director of Division of Endocrinology, Diabetes and Metabolism, St. Louis University School of Medicine.

Uncovering Insights Into the Current TRT LandscapeResults from the survey showed challenges and potential solutions to effectively treat men with low or no testosterone. More than one-quarter of patients do not take their TRT as prescribed, according to physicians surveyed. For 71% of patients, oral medication is the preferred choice, but only 22% percent are aware of them. Lastly, half of physicians (50%) are unaware of current oral TRT and its proven safety profile.

"This reinforces the need for continued education on TRT and the importance of working closely with patients on a treatment plan. With a better understanding of safe and effective TRT options, we can improve adherence, minimize the need to switch treatments and help patients get the care they deserve," said AdrianDobs, M.D., Professor of Medicine and Oncology, The Johns Hopkins School of Medicine.

To explore the data driving these insights, visit http://www.JatenzoHCP.com to download the presentation of results and findings.

About the Survey In February 2024, Sermo conducted a survey of 303 physicians, including endocrinologists, urologists, primary care physicians and others experienced in prescribing testosterone-replacement therapy (TRT). The objectives of the survey were to: 1) understand the TRT patient experience and unmet needs; 2) outline prescribing behaviors and barriers across multiple specialties; and 3) uncover barriers to treatment and opportunities for patient and peer education.

About Tolmar Inc. Tolmar is a fully integrated pharmaceutical company focused on the development, manufacturing, and commercialization of specialty pharmaceuticals across multiple therapeutic areas, including Endocrinology. Tolmar's product development and manufacturing facilities are based in Northern Colorado and its executive offices and commercial headquarters are based in Buffalo Grove, Illinois. For more information about the company, please visit http://www.tolmar.com.

About Sermo Sermo is the largest global healthcare research company and the most trusted physician and provider engagement platform. Sermo engages with more than 1.5 million HCPs across 150 countries and has reach into the U.S. Payer market that now exceeds 230M commercial lives covered.For over 20 years, Sermo has been turning physician experience, expertise, and observations into actionable business insights that benefit pharmaceutical companies, healthcare partners, and the medical community at large. Sermo offers on-demand access to HCPs via a proprietary health-tech ecosystem to gain targeted HCP insights that inform strategic decisioning in real-time. To learn more, visit http://www.sermo.com.

About JATENZO

Indication

JATENZO (testosterone undecanoate) capsules, CIII, is an androgen indicated for testosterone replacement therapy in adult males for conditions associated with a deficiency or absence of endogenous testosterone:

Primary hypogonadism (congenital or acquired): testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, orchiectomy, Klinefelter syndrome, chemotherapy, or toxic damage from alcohol or heavy metals. These men usually have low serum testosterone concentrations and gonadotropins (follicle-stimulating hormone [FSH], luteinizing hormone [LH]) above the normal range.

Hypogonadotropic hypogonadism (congenital or acquired): gonadotropin or luteinizing hormone-releasing hormone (LHRH) deficiency or pituitary-hypothalamic injury from tumors, trauma, or radiation. These men have low testosterone serum concentrations but have gonadotropins in the normal or low range.

Limitation of use Safety and efficacy of JATENZO in males less than 18 years old have not been established.

IMPORTANT SAFETY INFORMATION

WARNING: INCREASES IN BLOOD PRESSURE

JATENZO can cause blood pressure (BP) increases that can increase the risk of major adverse cardiovascular events (MACE), including non-fatal myocardial infarction, non-fatal stroke and cardiovascular death.

Before initiating JATENZO, consider the patient's baseline cardiovascular risk and ensure blood pressure is adequately controlled.

Periodically monitor for and treat new-onset hypertension or exacerbations of pre-existing hypertension and re-evaluate whether the benefits of JATENZO outweigh its risks in patients who develop cardiovascular risk factors or cardiovascular disease on treatment.

Due to this risk, use JATENZO only for the treatment of men with hypogonadal conditions associated with structural or genetic etiologies.

CONTRAINDICATIONS

JATENZO is contraindicated in men with breast cancer or known or suspected prostate cancer. JATENZO is contraindicated in women who are pregnant as testosterone may cause fetal harm.

WARNINGS AND PRECAUTIONS

Check hematocrit prior to initiation and every 3 months while a patient is on JATENZO and if hematocrit becomes elevated, stop JATENZO until hematocrit decreases to an acceptable level.

If hematocrit increases after JATENZO is restarted, stop permanently.

Monitor patients with benign prostatic hyperplasia (BPH) treated with androgens due to an increased risk for worsening signs and symptoms of BPH.

Venous thromboembolic events (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), have been reported in patients using testosterone replacement products like JATENZO. Evaluate patients with signs or symptoms consistent with DVT or PE and, if a VTE is suspected, discontinue JATENZO and initiate appropriate workup and management.

Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids.

Large doses of androgens can suppress spermatogenesis by feedback inhibition of pituitary FSH. Inform patients of this risk before prescribing JATENZO. Prolonged use of high doses of methyltestosterone has been associated with serious hepatic adverse events. JATENZO is not known to cause these adverse events; however, patients should be instructed to report any signs of hepatic dysfunction and JATENZO should be discontinued while the cause is evaluated. Edema, with or without congestive heart failure, may be a serious complication in patients with pre-existing cardiac, renal, or hepatic disease. In addition to discontinuation of the drug, diuretic therapy may be required.

Gynecomastia may develop and persist in patients being treated for hypogonadism.

Sleep apnea may occur in some patients, especially those with risk factors such as obesity or chronic lung disease.

Changes in the serum lipid profile may require dose adjustment of lipid-lowering drugs or discontinuation of testosterone therapy. Monitor the lipid profile periodically, particularly after starting testosterone therapy.

Use JATENZO with caution in cancer patients at risk of hypercalcemia. Monitor serum calcium concentration regularly during treatment with JATENZO in these patients.

Androgens, including JATENZO, may decrease concentrations of thyroxine-binding globulin, resulting in decreased total T4 serum concentrations and increased resin uptake of T3 and T4. Free thyroid hormone concentrations remain unchanged, however, and there is no clinical evidence of thyroid dysfunction. Depression and suicidal ideation have been reported in patients treated with JATENZO in clinical trials.

ADVERSE EVENTS

The most common adverse events of JATENZO (incidence 2%) are headache (5%), increased hematocrit (5%), hypertension (4%), decreased HDL (3%), and nausea (2%).

These are not all of the risks associated with JATENZO. For more information, clickherefor full Prescribing Information, including BOXED WARNING on increases in blood pressure.

Company Contact: Steve Yuan [emailprotected] 224.880.1616

SOURCE Tolmar Inc.

See the original post:
Tolmar Announces Results From Inaugural Landmark Survey of US Physicians To Assess Current State of ... - PR Newswire


Jun 4

Testosterone Levels Are More Than Just A Number | The Mike O’Hearn Show – Generation Iron Fitness Network

In a recent episode of The Mike OHearn Show, fitness legend Mike OHearn hosts Dr. Rand McClain to discuss the health implications of bodybuilding and fitness trends among the younger generation. The conversation spans a wide array of topics, from the benefits of early athleticism to the risks of extreme bodybuilding practices and the nuanced understanding of testosterone therapy.

Dr. Rand McClain is a renowned physician specializing in regenerative medicine and sports medicine. He holds a medical degree from Western University of Health Sciences and has dedicated his career to pioneering advancements in hormone therapy, anti-aging treatments, and regenerative health practices. Dr. McClains expertise extends beyond traditional medicine, incorporating cutting-edge techniques to enhance patients quality of life and athletic performance.

Dr. McClain returns to the podcast to discuss TRT, testosterone levels, and fitness as we age in more detail. More specifically, he details the delicate balance in preventing long term health issues before its too late while also preventing over use of certain treatments due to blanket rules in the medical community that may isolate certain individuals. Lets dive in!

Mike OHearn begins the conversation by addressing the promising future that young athletes and bodybuilders can secure for themselves through early and sustained physical fitness. He refers to this as a free ticket to health in middle age, emphasizing that a robust foundation in youth translates to a healthier and more resilient body in later years. Mike underscores the long-term benefits of staying fit, such as reduced health declines and enhanced quality of life during ones twilight years.

However, Mike expresses concern over a growing trend among the younger generation to push their fitness to dangerous extremes. Many young bodybuilders today aim to emulate the mass monster physiques of legends like Ronnie Coleman, often resorting to excessive drug and steroid use to achieve these goals. Mike warns that this approach is detrimental to long-term health, leading to severe consequences such as reduced natural testosterone levels, weakened joints and connective tissues, and an increased risk of cardiovascular diseases by the time they reach their 40s.

Dr. McClain concurs with Mikes observations, noting that social media has significantly influenced young aspiring athletes and bodybuilders. The widespread availability of information on drug and steroid protocols, coupled with the ease of obtaining these substances online, has exacerbated the problem. Moreover, the visibility of extreme and often unhealthy physiques on platforms like Instagram has set unrealistic and dangerous standards for young people.

Dr. McClain explains that the constant exposure to these images leads young individuals to believe that achieving such physiques is not only desirable but also easily attainable through steroids alone. This misconception overlooks the numerous other factors that contribute to such body compositions, including genetics, years of rigorous training, and meticulous dietary practices. He cautions that indiscriminate steroid use at a young age can drastically shorten lifespan and degrade the quality of life in later years.

RELATED: Bodybuilders Are Dying An Investigation Into Modern Bodybuilding, Health, & PED Use

Both Mike and Dr. McClain emphasize that becoming a successful bodybuilder or athlete is a marathon, not a sprint. It requires decades of dedicated training, yet many young athletes seek shortcuts through steroids to fast-track their progress. This impatience often results in severe health issues down the line, undermining the very goals they set out to achieve.

Dr. McClain also sheds light on the broader benefits of testosterone beyond muscle building. While testosterone replacement therapy (TRT) is commonly associated with enhanced body composition, it also plays a critical role in cognitive functions. Individuals with low testosterone levels frequently experience brain fog and diminished focus, which can be significantly improved with TRT. Although patients rarely seek TRT for cognitive benefits initially, many report feeling more alert and mentally sharp after undergoing therapy.

Dr. McClain advocates for a more individualized approach to assessing testosterone levels, challenging the medical communitys reliance on rigid norms. He argues that what is considered normal testosterone levels can vary significantly between individuals. For instance, a 25-year-old with historically high testosterone might feel the adverse effects of a decline in their levels, even if those levels are within the average range for the general population.

This nuanced perspective is crucial for providing optimal care. Dr. McClain illustrates this with the example of Mike OHearns partner, Mona Muresan, a former Ms. Universe winner with exceptionally low natural testosterone levels. Despite this, Mona maintains high energy levels and impressive physical strength. Dr. McClain suggests that in such cases, TRT might not be necessary unless other symptoms or preventative concerns arise.

Conversely, Dr. McClain points out that individuals with seemingly normal testosterone levels but poor physical health might have underlying conditions like polycystic ovary syndrome (PCOS). Therefore, a comprehensive evaluation of each patients unique medical history and current health status is essential for determining the appropriate treatment.

The discussion between Mike OHearn and Dr. Rand McClain highlights the complexities of modern bodybuilding and fitness. While early athleticism can lay the groundwork for a healthier future, the pursuit of extreme physiques through steroid abuse poses significant risks. Dr. McClains insights into the broader benefits of testosterone and the need for personalized medical evaluations underscore the importance of a balanced and informed approach to health and fitness. As the conversation reveals, understanding the individuals unique needs and history is paramount in promoting long-term well-being.

You can watch the full episode of the The Mike OHearn Show above. And dont forget to check back every week for new episodes on the Generation Iron Fitness Network or wherever podcasts are downloaded!

Go here to see the original:
Testosterone Levels Are More Than Just A Number | The Mike O'Hearn Show - Generation Iron Fitness Network


Jun 4

The Outsiders – A Moving Tale Of Muscular Misfits And Chosen Family Instinct Magazine – Instinct Magazine

The cast of The Outsiders (photo: Matthew Murphy)

Amid an intoxicating blend of testosterone and tenderness, the gripping new Broadway musical The Outsiders shares a coming-of-age story of family bonds (both chosen and blood-born) and the eternal clash of haves and have-nots.

Adapted from S.E. Hintons 1967 novel and Francis Ford Coppolas iconic 1983 film adaptation, The Outsiders (book by Adam Rapp and Justin Levine) follows the Curtis brothers, who live on the wrong side of the tracks in Tulsa, Oklahoma, circa 1967. Our narrator, Ponyboy (Brody Grant in a stunning Broadway debut), is a sensitive teen with aspirations of a better life.

He lives with his two brothers older brawny bro Sodapop (Jason Schmidt, who garners whoops from the audience by doffing his shirt within seconds) and eldest brother Darrel (Brent Comer), whos become the stand-in father figure since their parents died in a train crash.

When not hanging with his bestie quiet, introspective Johnny Cade (Sky Lakota-Lynch) Ponyboy spends his time writing in his notebook and reading the classics like Dickens Great Expectations.

Along with several others in their neighborhood, they are part of the lower-class Greasers, who often clash with the more privileged Socs (short for socials) who live on the west side of town, led by Bob (Kevin William Paul) and his sweetheart girlfriend Cherry (Emma Pittman).

Among the Greasers is ex-con Dallas (Joshua Boone), who takes Ponyboy and Johnny under his wing. When an innocent drive-in conversation between Ponyboy and Cherry leads to a tragic encounter with Johnny killing one of the Socs in self-defense, Dallas gives the two boys money and directs them to hide from the police in an abandoned church.

During their time in hiding, the duo reflect on the journey that brought them to here, and Ponyboy shares his love for the Robert Frost poem Nothing Gold Can Stay with Johnny which sets the stage for one of the musical highlights of the evening.

What follows is a tragic chain of events including a church fire, a suicide, and a final clash between the Greasers and the Socs before were left with a hint of hope on the horizon. While its a universal story, queer theatergoers will definitely connect with the plight of marginalized young people who have felt other (aka outsiders).

Danya Taymors direction artfully handles the storytelling, keeping the pace on point and constantly repurposing surrounding junkyard items (set by design collective AMP) to create each setting from the drive-in movie, to the abandoned church, the Curtis home, Ponyboys bed, and more.

Major props to Rick and Jeff Kuperman for their oh-so-muscular choreography, especially in the much-talked-about, spectacular, rain-soaked rumble. Paired with brilliant lighting by Brian MacDevitt and cinematic sound design by Cody Spencer, its a theatrical must-see moment.

The winning score by Jamestown Revival (Jonathan Clay & Zach Chance) and Justin Levine has just the right touches of guitar-based folk/Americana to remind us were in late-60s Oklahoma. Just a few standout songs include: Dallass first-act closer, Run Run Brother, as well as his second-act heartbreaker, Little Brother; the emotionally shattering Stay Gold, delivered by the pitch-perfect Ponyboy and Johnny; and the soul-baring Throwing in the Towel, wherein Darrel tells Sodapop he fears hes failed Ponyboy.

The outstanding cast (which includes ten actors making their Broadway debut) is impressive across the board. With 12 Tony Award nominations, its not surprising that Brody Grant scored a nod for Best Performance By An Actor In A Leading Role In A Musical, and Sky Lokota-Lynch and Joshua Boone were honored in the Best Performance By An Actor In A Featured Role In A Musical category. Additional nominations include Best Musical, Best Book, Best Score, Best Direction, and Best Choreography.

The Outsiders is running now at the Bernard B. Jacobs Theatre. (Rated 5 out of 5 stars)

Read the original post:
The Outsiders - A Moving Tale Of Muscular Misfits And Chosen Family Instinct Magazine - Instinct Magazine


Apr 26

Testosterone Therapy May Combat Heart Disease in Older Women – Mirage News

While there is a lot of hype around testosterone therapy for postmenopausal women, there is no denying that testosterone is an important hormone for women.

By the time a woman reaches their mid-fifties testosterone blood levels are about one quarter of what they were at their peak in their twenties. Surprisingly there is increasing evidence that testosterone is protective of the heart. So, researchers are asking the question, could this decrease in testosterone be putting women at risk when it comes to their heart?

Researchers from the Baker Heart and Diabetes Institute and Monash University's Women's Health Research Program are leading a world first study to see if testosterone therapy can prevent the development of heart failure in postmenopausal women.

Heart failure is a condition where the heart cannot pump enough blood to match what the body needs. This condition develops silently and impacts half a million Australians.

Heart failure is most common in women with high blood pressure, who are overweight or have obesity, or diabetes. The changes that lead to heart failure occur well before there are any symptoms the very early changes can be detected by an echocardiogram.

Our researchers will investigate whether supplementing testosterone in postmenopausal women can prevent the development of heart failure and improve exercise capacity.

We are seeking postmenopausal women in Melbourne, aged 55 years and over, who are at high risk of future heart failure (such as have high blood pressure or are overweight) to be in the study.

The study involves use of a testosterone cream (approved for use in women) for 4 months and an identical placebo cream for 4 months in random order. Heart function will be measured by exercise testing and echocardiography (heart ultrasound).

Read the rest here:
Testosterone Therapy May Combat Heart Disease in Older Women - Mirage News


Apr 18

Reg Wydeven column: Serious risks come with taking testosterone – Post-Crescent

postcrescent.com wants to ensure the best experience for all of our readers, so we built our site to take advantage of the latest technology, making it faster and easier to use.

Unfortunately, your browser is not supported. Please download one of these browsers for the best experience on postcrescent.com

Read more:
Reg Wydeven column: Serious risks come with taking testosterone - Post-Crescent



Page 11234..1020..»


matomo tracker