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Jun 8

Prostate cancer: Thousands of men to benefit from new drug approved for use on NHS – Sky News

Thousands of men are set to benefit from a new prostate cancer drug which has been approved for use on the NHS.

The National Institute for Health and Care Excellence (Nice) has recommended enzalutamide as an option for treating some types of the disease.

Prostate Cancer UK said the news was welcome for thousands of men, especially those who are unable to have chemotherapy.

The drug has been used during the pandemic as a so-called "COVID-friendly" cancer drug, which patients can take at home instead of needing intravenous medication in a health setting.

Now new draft guidance from Nice should enable wider use.

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The guidance says the drug, also known as Xtandi and made by Astellas, can be used with androgen deprivation therapy (ADT), as an option for treating hormone-sensitive metastatic prostate cancer in adults.

Angela Culhane, chief executive at Prostate Cancer UK, said: "This is fantastic news for thousands of men with advanced prostate cancer, especially those who have additional illnesses that make them unsuitable for chemotherapy.

"It finally guarantees them access to a treatment which is just as effective as chemotherapy and can give them back precious time with their families."

There are an estimated 8,500 men who will be able to access the drug, which works by blocking the effect of the hormone testosterone on prostate cancer cells.

Without testosterone, the prostate cancer cells cannot grow, even if they have spread to other parts of the body.

Clinical trials have shown that the treatment increases the time until the disease gets worse and how long people live.

Meindert Boysen, deputy chief executive and director of the Centre for Health Technology Evaluation at Nice, said: "Enzalutamide plus ADT offers another option for people with hormone-sensitive metastatic prostate cancer, especially for people who cannot have docetaxel, or who choose not to have it because of its side effects."

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Prostate cancer: Thousands of men to benefit from new drug approved for use on NHS - Sky News


Jun 8

Can This Denver Teacher Make Biology Class More Inclusive? – 5280 | The Denver Magazine

Samuel Long is a Denver teacher advocating to incorporate gender inclusive biology in high school curriculum. Photo courtesy of Samuel LongCelebrating Denver Pride: Community, Resilience, and Change

Samuel Long has a history of working for equity for LGBTQ students and staff in education. His work on gender inclusive biology carries on that tradition.

Samuel Long had always loved science. But in 2015, when he began his career as a high school biology teacher at DSST Stapleton High School (now called DSST Montview High School), he started to notice details in the curriculum that didnt sit right with him. Classroom materials never defined the difference between sex and gender, for example, and they consistently used words like male and female without much nuance. Readings called testosterone a male hormone even though it plays a role in every persons development, Long says.

At first, Long didnt say anything. This was how biology had been taught for a long time, after all, and he figured students wouldnt be interested in digging deeper into research about the complexities of gender and sex.

But then, during one lesson, a reading referred to intersex chromosomal arrangementssex chromosomes other than XX or XYas disorders of sexual development. The phrasing, while accepted in some medical literature, obscured the robust debate being had amongst researchers, doctors, and advocates about the proper way to classify members of the intersex community. Many argue that the phrase disorder carries a negative connotation and obscures the fact that some intersex people live perfectly happy and healthy lives. Others point out that certain chromosomal variations do lead to health consequences, like short stature and heart defects associated with Turner syndrome (when a female is missing some or all of an X chromosome).

Long didnt want to gloss over those conversations or risk alienating or invalidating his intersex and transgender students, including those who were not yet out. So, one day in 2015, he began class by telling students that sex and gender are separate, and that both can be on a spectrum. He was nervous, but the class was unfazed.

I remember that day was the first time I had ever heard about chromosomes as they really are, says Max Gregg, then a student in Longs class. There is all of this complication. And you can actually wind up having an unusually high number of sex chromosomes and have a completely normal and human life.

And thus, an initiative to change how biology is taught was born.

The high school biology curriculum most teachers and schools use still takes a highly binary approach to sex, gender, and sexuality, even though scientists are learning more about how complex these topics can be. Students themselves, Long says, can undoubtedly see the shades and colors of sex, gender, and sexuality all around them.

Teaching biology the traditional way can leave students who arent straight or cisgender confused, isolated, disenfranchised, and disinterested in engaging in the classroom, Long says. According to the Gay, Lesbian, and Straight Educators Network (GLSEN)s 2013 National School Climate Survey, LGBT high school seniors were more likely to be interested in studying STEM (Science, Technology, Engineering, or Math) in college if their relevant high school classes had included positive LGBT content (35.8% vs. 18.5%). The report also noted that LGBT students at schools with inclusive curricula were less likely by about half to have missed school in the past month and felt more connected to the school community.

Reading materials that emphasize that the male/female binary is rooted in biology can lead to more prejudice against trans people, according to research published in 2018.

A 2019 study from Colorado Springs BSCS Science Learning (the nonprofit studies and improves science curricula and instruction), came up with a similar finding: Something as simple as teaching high school students about plant sexual differences made students more likely to believe in neurogenetic essentialismthe idea that the differences between men and women can be solely attributed to innate, biological variations in their genes and brains, even though most researchers agree that external factors like societal expectations play a role. One problem with neurogenetic essentialism? It can often lead girls to believe incorrectly they arent well-suited for science. Its validating a broader cultural idea theyve acquired by growing up in our sexist society, says Brian Donovan, a senior research scientist at BSCS that worked on the study. The kids take that knowledge, and it reinforces their underlying ideas about gender.

Thats why, in 2019, Long and two other biology teachers (Lewis Stellar, in Seattle, and River Suh, in San Francisco) co-founded Gender Inclusive Biology (GIB), an initiative aimed at developing, promoting, and training educators on teaching biology in a way that is inclusive of LGBTQ identities. They run a website with resources for other teachers, curate a monthly newsletter that reaches 322 educators across the United States, and lead workshops for educators, curriculum developers, and administrators both privately and at conferences.

GIBs tools provide educators with actionable, accurate methods for making the curriculum more inclusive. The language guide, for example, points out binary terminology normally used in textbooks and classrooms, such as Women produce eggs and men produce sperm. The guide suggests focusing on the organ, functional activity, or role, instead of gender. So, a teacher might say ovaries produce eggs. Its scientifically accurate, and wont leave a young trans woman feeling less-than.

Long knows all too well the challenges of being a trans kid in non-supportive environments. When he came out as a transgender man in high school and began gender-affirming treatments, he faced push-back from his schools principal. She said you shouldnt use the boys bathroom because youre not a boy. But you shouldnt use the girls bathroom because your appearance is going to scare other girls. And so that didnt leave me with any options, Long says.

After graduating in 2009 from Don Mills Collegiate, a high school in Toronto, Canada, he got in touch with the Ontario Human Rights Legal Support Center and filed a lawsuit against the school. The suit was settled out of court, but Long says it created change for other students like him. The school district had to create a policy for exactly how to accommodate trans students in restrooms and other places, Long says. The school district declined to comment.

That victory showed Long the benefits of advocacy. When he moved to Colorado to start his first teaching job, he surprised himself by coming out to the staff the summer before classes started. I didnt expect that I would do that so soon. But I really felt in the midst of all these icebreakers and reflectiveness and getting to know people, that it was what I wanted to do. His fellow teachers reactions were positive, and with the support of the principal, Long decided he would come out to not only his students but to the whole school that November.

The school invited the students parents and family members to an assembly about transgender issues. There, Long came out, taking care to teach the students the correct definition of transgender and making it clear that his story was personal to him, not universal. I rehearsed what I said so much that I even remembered it the next year and said the same thing, Long says.

Some students watched silently. Others snapped emphatically in support when Long mentioned returning to his high school to file a lawsuit and became even more emphatic when he told them he won and got to consult on creating new policies for the district. Several students and parents came up afterward to shake his hand. Later, Long met with some queer-identifying students who wanted to ask more questions.

Long points out that many of the themes of his story resonate with high school students. He tells them about his arguments with his mom. She would say Im losing you. And that just made no sense to me because I was right there. But I realized that she couldnt see me for who I was, Long says. I think a lot of high schoolers have an experience where they arent being seen for who they are. And similarly, I think a lot of people in high school can relate to this idea of having to live with injustice, and trying to think about what you can do about it.

Along that vein, Long advocates for the rights of trans educators. Trans teachers fill a role that nobody else really can, which is to show young people who are trans or questioning that its possible to have a happy life, Long says. But he knows many who moved to tutoring or left teaching entirely because of pushback when they wanted to come out. Thats a big loss for schools in Colorado, he says.

To make sure more trans teachers can be true to their identities at work, Long founded the Colorado chapter of the Transgender/Nonbinary Educators Network (TEN). Last year, TEN successfully advocated for a change to Colorados Civil Rights Commission rules and regulations that meant schools cant prevent educators from being open about their gender identity.

Long and his team are just one part of a growing movement to make biology education more affirming. BSCS founded an Equity and Social Justice Initiative in 2018 that focuses on making sure science education is inclusive, relevant, and actively antiracist and anti-oppressive in all its forms. Long works with BSCS as an advisor and consultant on certain initiatives, and BSCS now uses the GIBs language guide.

Donovan, the researcher from BSCS, points out that Long is ahead of BSCSs research, but hopes to see studies done on the GIB curriculum. Do those changes when implemented in the curriculum itself lead to feelings of greater social belonging among trans students? Donovan asks.

Still, others in the education world continue to seek out Longs knowledge. He consults with textbook and curriculum developers like Gale In Context, Gale Health & Wellness databases, and OpenStax. The GIB founders have presented at conferences and written feature articles for the National Science Teaching Association. Long is currently consulting on interactive biology lab simulation software for HHMI Biointeractive, a philanthropy that creates classroom resources based on peer-reviewed science. He received and Upstander Award from the Human Rights Campaign last year, and the National Education Association awarded him the NEA Human and Civil Rights (HCR) Award, the groups highest honor, this month.

That doesnt mean GIB is free from pushback. Sometimes students or their parents ask why were learning about gender in science class, Long says. Usually, explaining that the content is scientifically accurate and inclusive quells concerns, but Long once had a GIB workshop canceled because schools were worried they might face backlash.

One teacher spoke to 5280 anonymously to avoid possible vitriol. After many years of teaching, she is adapting some of her lessons because she wants students to feel like theyre part of the community and the learning environment, not just observers, not just outsiders. She wants people to understand that educators like her arent changing the science. Were including this gender identity in the curriculum, just as we included material to empower girls, just as were including material to empower Black scientists.

She notes that she has seen queer-identified students in her class cringe and get uncomfortable when she teaches about something as simple as pedigree analysis, where the square means male, the circle means female. If a student isnt comfortable in the classroom, their ability to learn is harmed, she says. You lost them, you lost the education. And we would like to develop these future scientists no matter what their gender identity is.

Long hopes to play a part in revising the Colorado state science standards to include gender inclusive biology. He also envisions something similar to the 2019 law, HB19-1192 Inclusion Of American Minorities In Teaching Civil Government, which requires Colorado schools to teach the history, culture, and social contributions of minorities in social studies curriculum. (Long is a representative on the commission that was created by that bill.)

But for gender-inclusive biology, Long intends to take a slightly different tack. I dont know what the bill will be called or anything. It could be similar to the social studies one, but I would like to frame it as a standard of quality in some way. To teach biology in a way that doesnt acknowledge gender and sexual diversity is not the traditional way. Its of inferior quality and care to our students.

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Can This Denver Teacher Make Biology Class More Inclusive? - 5280 | The Denver Magazine


Jun 8

Global Region to Remain one of The Leading Outlook for Testosterone undecanoate Market Through 2028 Clark County Blog – Clark County Blog

Global Testosterone undecanoate Market By Type (Injection,Oral), By Application (Primary hypogonadism,Hypogonadotropic hypogonadism,Late-onset hypogonadism) Geography (North America (United States, Canada and Mexico), South America (China, Japan, Korea, India and Southeast Asia), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), Middle East and Africa (Saudi Arabia, Egypt, Nigeria and South Africa)) Industry Trends 2021-2028

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Global Region to Remain one of The Leading Outlook for Testosterone undecanoate Market Through 2028 Clark County Blog - Clark County Blog


Feb 4

2021 Ford F-150 Raptor is high-speed off-roader with cult following – Detroit Free Press

The third generation 2021 Ford F-150 Raptor is an epic high-speed off-road performance pickup truck that goes on sale this summer. Wochit

This insane truck was once killed in development.

Then resurrected.

On sale this summer, the third generation 2021 Ford F-150 Raptor is a high-speed, off-road, performance pickupwith what has become a cult following, owners whowantto go 100 mph in the desertand fly through the air over ruts and rocks. The Raptor that debuted on Wednesday adds new features, including a built-in generator to power anything fromcampsites to power tools.

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The beefy 37-inch tires and wheels and cutting-edgesuspension deliver stability despite the extreme terrain even while you're holding onto the "oh, sh*t" handle.

Normally, you'd have to tear apart a vehicle to get it to fit such enormous tires. These are stock, not special order. And they're 2 inches bigger than earlier models.

More: Top designer of Ford F-150 Raptor gets ideas from fighter jets, Hollywood

Getting this level of equipment, once custom, is now turnkey. Itlifts the truck to a new level. And the sound of the exhaust is a "deeper more menacing sound."

If testosterone had a soundtrack, this would be it.

This is a high-performance war that started a decade ago.

"We couldn't be more excited. Ford invented the off-road high performance pickup segment withthe first generation Raptorin 2009. It was truly inspired by the trophytrucks thatraced the Baja 1000," said Todd Eckert, Ford Truck Group marketing manager.

The Raptorwas so different from anything that had been done before that it took awhile for some people at Ford towake up to the fact the company could create a whole new category of high performance off-road pickups. So initial plans were shelved.

The passion of the Fordteam internally played a role in resurrecting the idea. Butas soon as the internet spreadrumors and spy photosof the truck, the groundswell ofenthusiast demand was enough to help get it resurrected.

This latest version will debut with the popular heavy metal song"Enter Sandman" by Metallica.

The 2021 Ford F-150 Raptor is known for its smooth flights through the air and comfortable landings.(Photo: Ford Motor Co.)

"Raptor was born not only to speed over rough terrain but also jump and catch air. It was a one-of-a-kind entry in the performance market," he said. "Over the last fouryears, thepresent generation Raptor cumulatively outsold Porsche'sentire line of sports cars and also outsoldChevrolet's Corvette."

2021 Ford F-150 Raptor has 37 inch tires and big wheels and all-new suspension.(Photo: Ford Motor Co.)

In 2018,Sergio Marchionne, then-CEO of Fiat Chrysler Automobiles,rolled out afive-year plan that included a vow tocompete with the Ford Raptor. The battle has been fierce;MotorTrend namedthe Ram 1500 TRX, a more powerful and expensive desert-racer,the 2021 Truck of the Year in December.

Ford will reveal the new Raptor's power, fuel economy, priceandspecifications closer to when sales begin. The previousRaptor runs $55,150 to $76,290 with destination and delivery fees included, Ford said..

The TRX's challenge to Raptorsupremacy as the ultimate racing truck won't go unanswered. Ford is expected to add a more powerful and expensive Raptor R model with a V-8 engine in 2022.

The 2021 Ram 1500 TRX pickup in rock climbing mode.(Photo: Mark Phelan, Detroit Free Press)

Battles to build sporty pickups have gone on for years.

The Detroit Three builtthe Ford Lightning, Chevy Silverado SS and Ram SRT-10 like the Mustang, Camaro and Dodge Challenger of pickupsin the early 2000s. Great for street racing.

More: Ford just revealed 2021 F-150: Why this new model is different

More: New F-150 design consumed his life and inspired his house

This is the modern day encore for desert racing.

"Off-road performance is in our blood," Eckert said.

2021 Ford F-150 Raptor sketches by exterior designer Tom Liu.(Photo: Ford Motor Co.)

The Raptor is for buyerswho want a truck to drive off-road straight from the factory while not compromising onpayload, towing, comfort ortechnology for daily use.

Features include a terrain management system, trail control and one-pedal drive. Terrain management allows owners to choose settings for driving conditions including sport, rock crawl andthedune-jumping, frequently airborne, Baja mode.

Thesystem automatically modifies steering feel, active valve exhaust, position-sensitive damping, throttle mapping and transmissionshift points to optimize Raptor's performance to conditions. Trail control is standard.

"Think of it as cruise control for low-speed driving," Eckert said. "Drivers just set a speed up to 20 mph and the Raptor manages throttle and braking to allow the driverto focus really only on steering.It makes it easier for drivers to maintain constant speeds over difficult terrain ... or for getting throughdeep snow or sand. It's activated simply using a button on the center console."

Sketch of the 2021 Ford F-150 Raptor by exterior designer Tom Liu.(Photo: Ford Motor Co.)

One pedal drive combines acceleration and braking; press to accelerate and release to brake. Just one footisneeded for off-road activity like rock crawling.

Raptor also has an onboard generator that prevents the need for a portable generator tocampor work, a key feature cited whenthe F-150 won the North American Truck of the Year.

More: Ford reveals new F-150 Tremor series in plan to dominate off-road action

Here is an animation of the new Fox shock system featured on the Ford F-150 Raptor. Detroit Free Press

The Ford team spent months in the desert torture testing.

"We start with a high-strength steel F-150 frame, which has been modified and reinforced for Raptor's extreme usage," said Tony Greco, Raptor program manager."The modifications and reinforcements which we makeinclude taller and stronger shock towers, unique control arm pivot locations, a lower front axle which is needed for increased travel, stronger bracketry for suspension, shocks and spring attachments and a Raptor-specific trailer hitch."

The Ford Raptor front shock.(Photo: Ford Motor Company)

Raptor's front and rear suspensions were redesignedto improve off-road traction and stability and on-road ride andhandling quality, he said.

"The new five-link suspension design ...stabilizes the rear axle laterally and dramatically improves traction, which allows more torque to the rear wheels to be put to the ground," Greco said. Result: faster acceleration and better throttle responsiveness.

A sketch of the 2021 Ford F-150 Raptor by exterior designer Tom Liu.(Photo: Ford Motor Co.)

There's moreto shareabout ball joints, knuckles, wheel bearingsand coil springsbut you get the idea. Anytime designers talk about "geometry changes" in vehicle discussions, well, it's a good thing.

This is about aggressive control and stability off-road and smooth plush ride on road.

If youre jumping, the further down your wheels are hanging, the more absorption you're going to get when you land, due to the shock absorbers stroking.

"That's where we see the big value in off-road events, when you're often up and down quite a bit. The shock technology and how we've deployed that on this vehicle," architecture engineer Jack Cooper said. "You can go faster in the desert, you can hit bigger things. If youdon't have as much travel and can't absorb that energy, you'll hit harder, the suspension will bottom harder, and it'll be less comfortable and not as durable in theend."

Jack Cooper with his daughter, Allison Cooper, outside his Ford office in Allen Park in 2018. The architecture engineer played a key role in developing the 2021 Ford F-150 Raptor.(Photo: Jack Cooper)

"We learn more and moreevery time we push the envelope. It's one of the best parts of my job, working with the vehicle dynamics team." said Cooper, whose brother is a software developer at Google."I have a dream job."

This Molten Orange first generation 2010 Ford F-150 Raptor is seen here in November 2008, possibly in Anza Borrego, California. The vehicle went on sale in 2009.(Photo: Ford Motor Co.)

Ford builds the Raptor in Dearborn.

Contact Phoebe Wall Howard: 313-222-6512or phoward@freepress.com. Follow her on Twitter @phoebesaid. Read more on Ford and sign up for our autos newsletter.

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2021 Ford F-150 Raptor is high-speed off-roader with cult following - Detroit Free Press


Feb 4

Coronavirus may cause sperm damage; Ways to boost male fertility – TheHealthSite

As we know, the impact of coronavirus is not limited to the respiratory system. It can lead to several complications, including fertility. A new study has finally found a link between coronavirus and male fertility. According to the study published in the Justus Liebig University Giessen, Germany found that severe cases of COVID-19 can impact the quality of sperm quality, thus affecting male fertility. Another study published in the Asian Journal of Urology found that SARS-CoV-2 could impact a mens reproductive health, including spermatogenic failure. Also Read - Here's how COVID-19 is affecting liver cancer patients and treatment

Although some studies have shown the negative impact of the coronavirus on male fertility, researchers said that more research is needed to draw definite conclusions. Meanwhile, there are certain things you could do to improve sperm count. Also Read - Jharkhand health staffer dies two days after getting COVID-19 vaccine

We cant stress the importance of exercise enough. Not only does it helps boost testosterone levels, but it also improves the quality of life. A study published in the European Journal of Applied Psychology, men who exercise regularly have higher testosterone levels and better semen quality as compared to men who dont exercise. Also Read - COVAX announces initial COVID-19 vaccine roll out: 336ml doses from AstraZeneca-SII, 1.2ml from Pfizer-BioNTech by March end

You probably know that vitamin C is an important nutrient that helps boost the immune system, but did you know that it is good for male fertility? Some studies have shown that including vitamin C can help improve fertility. It has also been reported that vitamin C supplements also enhanced sperm count and motility (bodys ability to move food through its digestive tract).

Studies have found that elevated cortisol levels (stress hormone) can have a negative effect on testosterone. Managing stress by exercising, spending time with your loved ones, meditating, and walking in nature can help.

A popular culinary ingredient, fenugreek contains properties that improve sexual health. A study published in the International Journal of Sports Nutrition and Exercise Metabolism studied the data of 30 men. They concluded that men who included fenugreek in their diet experienced a significant increase in testosterone levels and strength. Another study showed that consuming fenugreek regularly can help improve libido, sexual performance and strength.

A traditional medicinal herb, ashwagandha may boost testosterone levels, thus improving male fertility. Several studies have shown that ashwagandha supplements can help better sperm count, sperm motility, and antioxidant status, all of which is good for male fertility.

While the above methods may help, some lifestyle changes may help too. Here are some tips that might help.

Published : February 1, 2021 5:37 pm

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Coronavirus may cause sperm damage; Ways to boost male fertility - TheHealthSite


Feb 4

All Creatures Great and Small Recap: The One With the Snack Hamper – Vulture

We love the things that help get us through hard times with a love that surpasseth understanding. With that in mind, I think you will understand when I say that this remake of All Creatures Great and Small is among the greatest things bestowed upon humankind in this last year. It is a gentle human drama filled with well-intentioned gentle humans trying their best, and the few times they are not trying their best, they are gently ashamed. I go into every new episode with the relief of I am about to watch a very nice thing. In these times, the appeal of that cannot be overestimated.

This entire episode revolves around a Pekingese. Yes, correct, it is the extremely wealthy Mrs. Pumphreys dog Tricki Woo, a dog I could not possibly love more, played by Derek. Wonderful dog acting from Derek once again this episode. Tricki is a pile of fluff. A Tribble of a dog. What is the greatest thing about Tricki? Is it his absurd leonine mane? The giant cushions he sleeps on? The fact that he shakes paws (I LITERALLY screamed when this happened)? His little snuffling noises? That Mrs. Pumphrey calls him my boofums? OR E, ALL OF THE ABOVE.

But before we get to Tricki, we also have Tristan. Or Tris, as I am forever calling him after last episode. Tris spends the episode asking Siegfried for money so he can go back to school and, presumably, have more fun than answering the phone at the practice and mixing horse medicine. Siegfried is understandably reticent because Tris keeps failing his exams, so Tris must prove himself. This somehow comes down to taking Tricki on walks, making the latter am I going to say it, yes I am a perambulating Pekingese (we have fun here). The practice has possession of Tricki because he is dangerously overweight. When asked if Mrs. Pumphrey has been sticking to his diet of dry dog biscuits, she says yes, to the letter, and then charmingly adds, perhaps not every letter. I AM STEALING THIS, DIANA RIGG. (RIP.)

She has been feeding Tricki calfs foot jelly, cod liver oil, Beef Wellington, and a bowl of Horlicks. If you are, like I am, an American, you might have said is that like ice cream? Nope! Think about milk, but its hot and also you add malt to it. I know, I dont get it either. Its slogan in 1961 was Horlicks the food drink of the night. NOPE. It was actually created in the United States and brought on expeditions to the North and South Pole, and then eventually that trickled on down to it being fed to the overly pampered Pekingese set.

James is concerned enough about Tricki that he takes him to stay at the practice so they can feed him appropriately and take him on walks. My notes for his visit at Mrs. Pumphreys just say GIMME THAT DOG, but we now need to move onto the very important fact that Tricki has a tiny, dog-size chaise longue. Has anyone made a website for Extravagant Pet Furniture, because I will look at that site every single day.

The drama of the episode hinges around the Hamper o Snacks, which Tris and Siegfried spend the following days pilfering. Despite Tris taking Tricki on very long walks and feeding him the presumably joyless dry dog food he must now consume for his health, Tricki is gaining rather than losing weight. This is because Siegfried left the hamper open and Tricki has been merrily dragging whole slices of ham out of it with his tiny dog strength. There is a big TO-DO about this, but! Lets talk about Clive real quick.

Dyou remember Clive? The massive bull who looks like one of those 18th-century paintings where you think that cows proportions are off, but really we just arent used to breeds of cow that arent Holsteins? Clive belongs to Helen and he has been sired out, i.e. hired to do it with someone elses cows, but hes not doing it, so James has to give him a shot of testosterone.

This is an unremarkable plot point, because the testosterone, undramatically, works, but its there to (1) let us once again see Clive, who is truly amazing and I love him, (2) show us everyone wearing velvet pants, or what I think are velvet pants, and it makes me want velvet pants, and (3) get James to give Helen a lift home, until they run into Hot Neville, who seems to have forgiven James for killing his horse. James has a Jessies Girl moment as he looks at the two flirting, but this dynamic remains the least interesting to me, because we know James and Helen are probably going to get married. Its very, yes, yes, check this off the list, now lets look at the others.

The relationships that are of true import here are Siegfried/Mrs. Hall and Mrs. Pumphrey/Tricki Woo. I cant nail down Siegfried and Mrs. Halls situation, and it makes me love it all the more. He knows more about her and her difficulties with her son than were allowed to know. He clearly feels something more for her, but its under enough layers of subtext that it seems hes not allowed to properly express it. They have this unspoken arrangement in their dynamic that I am all about and it feels like the actors have sat down and had a good discussion about their backstory and ITS JUST SO GOOD. As for Mrs. Pumphrey and Tricki Woo, that is a love for the ages.

Will we ever find out Whats Up With Edward?

Do velvet pants wear well?

When Helen inevitably dumps Hot Neville, will he find solace in the world of botany?

Will I descend into the uttermost depths of the All Creatures fandom, and now that weve found out the practices telephone number, change my WiFi Network to Darrowby2297?

Keep up with all the drama of your favorite shows!

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All Creatures Great and Small Recap: The One With the Snack Hamper - Vulture


Feb 2

Testosterone for Managing Treatment-related Fatigue in Patients With Metastatic Renal Cell Carcinoma: A Pha… – UroToday

Fatigue is one of the most common adverse events of systemic therapy in patients with metastatic renal cell carcinoma (RCC). The aim of multicenter randomized phase 2 study was to determine the efficacy and safety of testosterone in patients with fatigue developed during targeted therapy.

Male patients with metastatic clear-cell RCC, normal prostate-specific antigen level, low testosterone level, and no evidence of hypothyroidism receiving first-line sunitinib or pazopanib with fatigue were randomly assigned (1:1) to either testosterone undecanoate (1000mg) and targeted therapy or targeted therapy alone. The primary endpoint was the mean change of fatigue from baseline to 28 days according to the Functional Assessment of Chronic Illness Therapy-Fatigue scale. Secondary endpoints were safety, Functional Assessment of Cancer Therapy-Kidney Symptom Index 19, testosterone serum concentrations, red blood cell count, and hemoglobin level.

Sixty patients were assigned to receive testosterone and targeted therapy (N=30) or targeted therapy alone (N=30). As of the data cutoff on December 30, 2019, median follow-up was 18.2 months. The study achieved its primary endpoint based on the significant differences at day 28 favoring testosterone over targeted therapy alone regarding the decreased level of fatigue (difference between groups, 22.5 points; 95% confidence interval, 18.4-26.6; P=0.012). Significant changes in scores demonstrating the enhanced quality of life with testosterone compared with targeted therapy were also observed for Functional Assessment of Cancer Therapy-Kidney Symptom Index 19 disease-related symptoms (P=0.01). There were nonsignificant differences in red blood cell count and hemoglobin level between the 2 groups (all P>0.05).

Male patients with metastatic RCC and hypogonadism receiving testosterone had less fatigue and better symptom control during targeted therapy.

American journal of clinical oncology. 2021 Jan 27 [Epub ahead of print]

Ilya Tsimafeyeu, Yulia Tishova, Ruslan Zukov, Pavel Borisov, Anastasia Bondarenko, Kristina Zakurdaeva

Kidney Cancer Research Bureau Institute of Oncology, Hadassah Medical Moscow RUDN University I.M. Sechenov First Moscow State Medical University RakFond, Moscow V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk City Clinical Oncology Center, St. Petersburg, Russia.

PubMed http://www.ncbi.nlm.nih.gov/pubmed/33512910

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Testosterone for Managing Treatment-related Fatigue in Patients With Metastatic Renal Cell Carcinoma: A Pha... - UroToday


Feb 2

Association of Metabolic Obesity Phenotypes and Total Testosterone in | DMSO – Dove Medical Press

Luna Liu,1,2 Shuang Liu,1,2 Qianmei Song,1,2 Dandan Luo,1,2 Yu Su,1,2 Xiangyu Qi,1,2 Qian Wang,3 Jing Ning,1,2 Youyuan Lv,1,2 Qingbo Guan1,2,4

1Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, Peoples Republic of China; 2Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong 250021, Peoples Republic of China; 3Department of Ultrasound, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, Peoples Republic of China; 4Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, Peoples Republic of China

Correspondence: Qingbo Guan Tel +86-531-68776375Fax +86-531-87068707Email doctorguanqingbo@163.com

Objective: Obesity and metabolic syndrome have been reported to exert an impact on the male reproductive system with decreasing levels of serum total testosterone (TT); however, the effect of different metabolic obesity phenotypes on testosterone has been poorly studied. We aimed to evaluate the association of metabolic obesity phenotypes and total testosterone levels in a Chinese male population.Methods: We performed a retrospective study based on an epidemiological investigation, a total of 4,081 male individuals aged from 40 75 years old were recruited. The population was classified as metabolically healthy normal weight (MHNW), metabolically healthy overweight/obese (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy overweight/obese (MUO) according to normal weight (BMI< 25.0) and overweight/obesity (BMI 25.0) with or without metabolic syndrome.Results: We collected 563 hypotestosteronemia among 4,081 male individuals. The odds ratios (ORs) (95% CIs) of hypotestosteronemia in obesity and metabolic syndrome were 3.072 (2.414 3.911) and 3.294 (2.631 4.125), respectively, after adjusting for age, luteinizing hormone, smoking status, and alcohol consumption. Compared to the MHNW group, male subjects in MHO, MUNW, and MUO groups had decreased serum TT levels. Additionally, the MUO group had a lowest concentration of serum TT and a highest proportion of hypotestosteronemia. There was no significant difference of TT levels between the MHO and MUNW groups.Conclusion: Obesity and metabolic syndrome are independent risk factors of hypotestosteronemia in Chinese male populations. Our study also suggested that individuals with MHO, MUNW, and MUO have a higher risk of developing hypotestosteronemia.

Keywords: metabolic obesity phenotypes, testosterone, metabolically healthy overweight/obese, metabolically unhealthy normal weight, hypotestosteronemia

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Association of Metabolic Obesity Phenotypes and Total Testosterone in | DMSO - Dove Medical Press


Feb 2

Marius Pharmaceuticals Announces Co-CEOs Himanshu H. Shah and Shalin Shah to Drive Growth ahead of Anticipated FDA Action of its Lead Asset, KYZATREX…

RALEIGH, N.C., Jan. 28, 2021 (GLOBE NEWSWIRE) -- Marius Pharmaceuticals, a specialty pharmaceutical company focusing on treating conditions that are primarily associated with testosterone deficiency, today announced that it has appointed Himanshu H. Shah and Shalin Shah as co-CEOs to drive the next phase of growth as the company looks to a potential launch of KYZATREX in Q4 2021 and further the development of Marius deep clinical pipeline.

Himanshu H. Shah brings over 30 years of experience across global capital markets and will continue his role as chairman of the board in addition to co-CEO. He has advised numerous public and private companies over the past decades to help them unlock substantial shareholder value and execute both innovative and pragmatic business strategies.

I am proud to continue serving Marius and work on developing the best treatment options for men with hypogonadism, a common but not widely discussed disease among patients and prescribers, said Himanshu H. Shah, chairman and co-CEO of Marius Pharmaceuticals. Misconceptions about hypogonadism are having a huge impact on the health of millions of men globally and costing the U.S. healthcare system alone billions of dollars annually. There is a huge opportunity for Marius to address these issues and drastically alter the testosterone therapy landscape.

Shalin Shah will also step into the role of co-CEO from chief financial officer and executive vice president of strategy for Marius. Shalin has been integral in driving overall strategy at Marius for the past four years and will oversee the growth of the team and execution of innovative models as it expands both clinically and commercially to become a leading pharmaceutical company.

I am excited for the opportunity to serve Marius in this new capacity, especially at a time when the world is seeing technology and healthcare intersect more than ever, truly helping patients, said Shalin Shah, co-CEO of Marius Pharmaceuticals. I am confident in Marius mission to better the lives of patients by ensuring adequate levels of testosterone and enhance patient care through disruptive technologies and personalization.

Om Dhingra, Ph.D., led the company from initial development of the lead compound through two successful Phase 3 clinical trials and will move into the role of vice chairman. He will help guide the companys clinical development plan and ensure KYZATREX and its differentiating safety and efficacy data is well known in the medical world.

It has been my great pleasure serving the company as CEO. I am very proud of the data we have generated, which we believe will position KYZATREX as the standard of care for patients suffering from hypogonadism globally, said Dr. Om Dhingra, vice chairman of Marius Pharmaceuticals.

If approved by the FDA, KYZATREX has the potential to become the new standard of care for treating patients with hypogonadism. Testosterone is a crucial hormone that is essential to sexual and reproductive health, but also has important functions in metabolic, inflammatory, cardiovascular and neurological health. In the U.S. there are at least six million symptomatic men suffering from hypogonadism, and over 100 million men globally. The resulting medical costs associated with men with untreated hypogonadism and related comorbidities are more than $25 billion in the U.S. alone. Current treatments on the market are dominated by therapies with unappealing administration methods, including auto-injections, in-office infusions and topical gels and creams that have a high transference risk. KYZATREX is an orally administered treatment that avoids the drawbacks that keep men from continuing treatment on available testosterone therapies.

About KYZATREX KYZATREX if approved, will represent a novel oral testosterone replacement therapy option for adult males indicated for conditions associated with a deficiency or absence of endogenous testosterone: primary hypogonadism (congenital or acquired) and hypogonadotropic hypogonadism (congenital or acquired).

The ReTUNE study was a multi-center, 12-month study across the U.S. that studied the safety and efficacy of KYZATREX in hypogonadal subjects (total testosterone 281 ng/dL). Efficacy was determined by number of subjects in the normal, eugonadal range after 90 days of treatment, including dose titrations, while safety was monitored for a further 9 months while on a steady dose. In addition to testosterone parameters, the study collected Patient Reported Outcomes (PROs), which showed statistically significant results both from baseline and against its comparator. A pivotal six-month Phase 3 study was conducted, in which subjects were monitored using ABPM, now considered the standard BP assessment by the FDA and clinical experts. An improved dose regimen was also used in the pivotal six-month Phase 3 study. The results of the Phase 3 studies will be published in leading medical journals and presented at national conferences in 2021.

The FDA has conditionally accepted KYZATREX as the trade name for this investigational drug. The safety and efficacy have not been fully evaluated by any regulatory authority.

About Marius PharmaceuticalsMarius is a specialty pharmaceutical company focusing on treating conditions that are primarily associated with hypogonadism, commonly referred to as testosterone deficiency. The companys mission is to improve the functional lives of patients and reduce the risks of the downstream effects of endocrine imbalance by ensuring appropriate level of testosterone. For more information, please visit http://www.mariuspharma.com.

Media Contact: Emily Brice919-610-3319ebrice@fwv-us.com

Photos accompanying this announcement are available at

https://www.globenewswire.com/NewsRoom/AttachmentNg/f825d70b-874a-4cef-9160-429f83bbfc66

https://www.globenewswire.com/NewsRoom/AttachmentNg/ba2569ca-0922-4b49-8d68-49424b5e44d4

Himanshu H. Shah

Co-CEO and Chairman of the Board, Marius Pharmaceuticals

Shalin Shah

Co-CEO, Marius Pharmaceuticals

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Marius Pharmaceuticals Announces Co-CEOs Himanshu H. Shah and Shalin Shah to Drive Growth ahead of Anticipated FDA Action of its Lead Asset, KYZATREX...


Feb 2

Testosterone Gel Market Analysis, Comperhensive Research: Sales, Consumption, Demand and Forecast 2020-2026 Murphy’s Hockey Law – Murphy’s Hockey Law

Testosterone Gel Market

The latest report on Testosterone Gel Market provides an overall assessment of the world market Testosterone Gel by classifying it into terminal applications, types and regions. The report presents a comprehensive analysis of the competitive landscape and strategies that have positively influenced the market. Furthermore, the report provides an overview of current market dynamics by looking at different key segments based on product, types, applications, end-to-end industries and market scenario.

The Testosterone Gel market research report concentrates on the analysis of demand and supply at the regional and national global level. From a global perspective, the report presents Testosterone Gel markets per size, analysing historical data and future perspectives. The report focuses on a number of key areas, including North America, Europe, Asia-Pacific and the West.

2020 has been considered the base year and the report provides a market estimate for 2020-2029. The report looks at the world market for the Testosterone Gel (size, capacity, production and consumption) in key regions.

AbbVie, Upsher-Smith Laboratories, Endo Pharmaceuticals, Teva, Dr. Reddy\s Laboratories, Perrigo, Lupin, Acerus Pharmaceuticals

0.010.0162

Primary hypogonadismHypogonadotropic hypogonadismLate-onset hypogonadism

About Us:We, Regal Intelligence, aim to change the dynamics of market research backed by quality data. Our analysts validate data with exclusive qualitative and analytics driven intelligence. We meticulously plan our research process and execute in order to explore the potential market for getting insightful details. Our prime focus is to provide reliable data based on public surveys using data analytics techniques. If you have come here, you might be interested in highly reliable data driven market insights for your product/service,reach us here 24/7.

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Testosterone Gel Market Analysis, Comperhensive Research: Sales, Consumption, Demand and Forecast 2020-2026 Murphy's Hockey Law - Murphy's Hockey Law



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