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Jun 13

15 Best Breakfasts for Weight Loss – Health.com

Starting your day with a balanced, nutritious breakfast is an easy and effective way to support your health.

Eating a protein and fiber-rich breakfast can promote optimal blood sugar regulation and give you sustained energy. It can also keep you full until your next meal and reduce your overall calorie intake, which could help you reach your weight loss goals.

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Eggs are rich in protein, easy to make, and serve as the base for several breakfast dishes, like egg muffins. You can make egg muffins by mixing eggs with chopped vegetables and a small amount of cheese, and then pouring the mixture into muffin tins and baking in the oven until solid. These are easy to meal prep; just make a bulk batch and freeze for later use.

Two eggs provide 12.52 grams (g) of protein, which is the most filling macronutrient. In addition to being high in protein, eggs are low in carbs and rich in essential nutrients like B12, selenium, and vitamin A.

Following diets higher in protein and lower in carbs is linked to several health benefits, including improved blood sugar regulation, reductions in heart disease risk factors like high triglyceride levels, and weight loss.

Also, studies show that eating eggs for breakfast may help you take in fewer calories later in the day, which can help encourage fat loss.

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Greek yogurt contains more than double the amount of protein found in regular yogurt, making it a smart choice for a weight loss-friendly breakfast. A 7-ounce (oz) container of Greek yogurt provides just under 20 g of protein, which can help youfeel satisfiedafter eating.

Topping Greek yogurt with fiber-rich foods can further boost your breakfast's weight loss-promoting potential. Protein and fiber both slow digestion, which increases feelings of fullness and helps you eat fewer calories, which encourages weight loss. For example, research shows that pairing yogurt with fiber-rich chia seeds leads to greater feelings of fullness compared to eating plain yogurt.

Try layering Greek yogurt with high-fiber ingredients, like chia seeds and berries, for a quick, yet satisfying breakfast.

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Oats, including rolled oats and steel-cut oats, are a popular breakfast choice as they're nutritious, filling, and versatile.

Though steel-cut oats take a bit longer to prepare than rolled oats, they're higher in protein and fiber, making them a better option for promoting satiety. A quarter-cup of steel-cut oats contains 5 g of protein and 4 g of fiber.

Top steel-cut oats with peanut butter for added protein and flavor. Look for a peanut butter with minimal added sugar to help reduce your sugar intake.

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Protein powdersare a helpful ingredient to keep in your kitchen as you can use them to prepare quick and nutritious meal and snack options, like protein shakes and smoothies.

If you're looking for a weight loss-friendly breakfast option that can be taken on the go, consider whipping up a protein-packed smoothie made with whey protein, frozen berries, nut butter, and water, milk, or plant-based milk. One scoop of whey protein isolate provides 25 g of protein, making it a satiating ingredient that can help boost weight loss and increase muscle mass.

A research review found that people who supplemented with whey protein experienced significant reductions in body weight and body fat compared to those who received placebo treatments.

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If you follow a plant-based diet or can't eat eggs, it can be challenging to find protein-rich breakfast options. Legumes, like chickpeas, are high in plant-based protein and fiber and can be used to prepare filling breakfast dishes.

Chickpeas provide 12.5 g of fiber per cooked cup. Fiber helps slow digestion, which helps you feel fuller after eating.

Research findings suggest that adding chickpeas and other legumes to your diet can reduce your hunger levels and help you eat fewer calories throughout the day, which can support weight loss and prevent weight gain. A recent study found that adults who ate more legumes, like chickpeas, had significantly less weight gain over a 10-year time period compared to adults with low legume intake.

To make a vegan-friendly breakfast, saut chickpeas with cubed sweet potatoes and sliced onions until the onions are caramelized and the sweet potatoes are soft.

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Combining protein-packedeggswithhigh-fiber vegetables creates a filling and nutrient-dense breakfast that will keep you satisfied through the morning.

Protein and fiber increase feelings of fullness by stimulating the release of satiety hormones such as peptide YY (PYY) and cholecystokinin (CCK) and slowing digestion, which can help you eat fewer overall calories.

You can make a frittata by combining whisked eggs, your favorite vegetables, herbs, and seasonings in a pie dish or cast iron skillet and baking at 400 for around 20 minutes.

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Though most people enjoy oats with sweeter ingredients, like fruit, oatmeal makes a healthy base for savory breakfasts, too.

Try making savory oatmeal by mixing cooked steel-cut or rolled oats with salt and pepper and topping your oats with protein and fiber-packed ingredients like eggs, cheese, and vegetables.

Oats can boost feelings of fullness after eating and support overall health by reducing heart disease risk factors like LDL cholesterol and improving the health of the digestive system.

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Chia seedsare packed with nutrients that support satiety and a healthy body weight, like fiber and protein. Chia seeds contain nearly 10 g of fiber per ounce, which helps you feel full. Fiber-rich foods, like chia seeds, also promote digestive health by keeping bowel movementsregular and encouraging the growth of beneficial bacteria in the gut.

To make chia pudding, combine 2 tablespoons (tbsp) of chia seeds with a half-cup of milk of your choice, such as cow's milk or coconut milk. Let the mixture sit in the refrigerator until it takes on a thick, pudding-like consistency. Top chia pudding with other nutritious, high-fiber ingredients, like seedsand berries.

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If you're craving something sweet yet nutritious, consider making protein pancakes. They require just a few ingredients and take minutes to prepare.

To make protein pancakes, blend 2 1/2cupsof rolled oats, two bananas, and two eggs in a high-speed blender until smooth. Pour the mixture in small dollops onto an oiled skillet and cook for 2-3 minutes per side on medium heat until the pancakes are fully cooked through.

Top your protein pancakes with Greek yogurt and berries for a sweet and satisfying breakfast option.

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Cottage cheese contains 23.5 grams of protein per cup, making it a good choice for those who want to lose weight. In addition to protein, cottage cheese provides vitamins and minerals that are essential to overall health, including calcium andB12.

Cottage cheeseis versatile and can work as a sweet or savory breakfast option. For a boost of fiber, top your cottage cheese with fresh fruit, like berries or sliced peaches, and chopped walnuts.

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If you struggle to find the time to prepare a healthy breakfast, a protein bento box can provide the energy you need to power through your day.

To make a protein-packed bento box, choose a few nutritious, high-protein foods, like hard-boiled eggs, hummus, and cheese, plus high-fiber foods, like fresh fruits and vegetables, and place them into a container with multiple compartments to keep your ingredients separated. You can make a few of these containers ahead of time to have for the week.

Try mixing up your protein bento box combinations to keep your breakfast options interesting and satisfying.

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If you think salad can only be eaten for lunch or dinner, think again. Greens, like arugula andspinach, are very low in calories and make a nutritious base for a filling breakfast.

To make a breakfast salad, top your favorite leafy greens with protein-rich ingredients like fried or hard-boiled eggs, cooked or raw vegetables, beans, cheese, and seeds.

Dress your salad with olive oil and apple cider or balsamic vinegar to add flavor and additional health benefits.

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Eating fiber-rich whole grains and pseudo grains, like quinoa, brown rice, and buckwheat, is associated with a number of health benefits.

For example, research suggests that people who eat whole grains are less likely to gain weight and develop obesity over time compared to people who eat refined grains.

For a quick, weight loss-friendly breakfast, top cooked quinoawhich is higher in protein than many other grainswith filling ingredients like eggs and sauted vegetables.

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Avocadosare packed with fiber, providing 13.5 g per avocado.

Study findings suggest that people who regularly consume avocados have less stomach fat and are less likely to gain weight over time compared to people who don't eat avocados.

For a simple breakfast, top whole-grain or gluten-free toast with mashed avocado and sliced hard-boiled eggs.

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Breakfast wraps are a smart choice if you're looking for a satisfying breakfast you can enjoy on the go.

Use a whole-grain, gluten-free, or low-carb wrap to roll up filling and nutrient-rich ingredients like eggs, beans, and vegetables.

You can customize your wrap based on your dietary preferences and health needs. For a vegan-friendly, high-protein breakfast, stuff your breakfast wrap with sauted veggies and scrambled tofu, which packs over 9 g of plant-based protein per 3 oz serving.

If you're trying to shed excess body fat, it's important to do so using safe and effective methods. It's best to avoid overly restrictive and very low-calorie diets, as these can be difficult to maintain and may cause you to develop a harmful relationship with food.

Instead, focus on transitioning to a nutritious diet high in filling foods, such as foods rich in protein and fiber, while limiting foods and drinks linked to weight gain and other health concerns, such as foods high in added sugar, fast food, and soda.

Remember to maintain proper serving sizes when eating nutritious foods high in protein and fiber, like the breakfasts above. These foods allow you to more easily reduce calories while still getting the nutrients you need, aiding in weight loss.

It's essential to create a calorie deficit to achieve weight loss. You can do this by eating fewer calories throughout the day or by increasing your energy expenditure by engaging in more physical activity.

It's important to note that extreme calorie restriction can lead to side effects such as a loss of muscle mass, increased appetite, and a drop in the number of calories you burn while at rest, which can make it difficult to maintain your weight loss long term.

To minimize these unwanted effects, many experts recommend creating a smaller calorie deficit, which may result in slower weight loss but can increase your chances of keeping the weight off long term.

While there are many evidence-based ways to support healthy weight loss, it's best to work with a qualified healthcare provider, like a registered dietitian, to come up with a weight loss plan that works best for your specific health needs and goals.

Eating a nutritious, balanced breakfast can help you start the day feeling full and energizedwhich can be an effective way to support weight loss.

Research shows that eating a breakfast high in protein and fiber-rich foods, like eggs, vegetables, beans, and Greek yogurt, can help improve feelings of fullness and help you eat fewer calories later in the day, encouraging healthy weight loss.

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15 Best Breakfasts for Weight Loss - Health.com

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Jun 13

"Lose Weight, Get Bonus": Chinese Tech Company Offers Weight Loss Incentives – NDTV

The program credits its success to the power of group dynamics.

Insta360, a tech company in Shenzhen, China, has gained recognition for its unique employee wellness program. The program incentivizes weight loss by offering nearly USD 140,000 in total bonuses.

Launched in early 2023, the program boasts impressive results. According to Jiupai News, over 150 employees collectively lost 800 kg and earned nearly USD 100,000 in rewards.

Structured like a weight-loss boot camp, the program lasts three months and enrols 30 employees per session, prioritizing those with obesity. As reported by the South China Morning Post, each session is split into three groups, with bonuses awarded based on average weekly weight loss within each group.

The program credits its success to the power of group dynamics. No participants gained weight during the camps, highlighting the added motivation it provides.

"Creating groups adds a moral dimension for employees," said Li, a staff member. "If you don't slim down, you affect not only your bonus but also that of your colleagues."

Li, who joined in November 2023, found the program appealing for both financial reasons and his health. He combined a controlled diet with daily exercise like running, swimming, and basketball, resulting in a 17.5 kg weight loss and a 7,410 yuan (US$1,000) reward.

The initiative received lots of praise on Chinese social media.

A user wrote, "What a fairy company it is. I wish I could work there."

Another user commented, "I would run 10 km every day and the company would soon be bankrupt with a staffer like me."

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Jun 13

Weight loss coach reveals 3 foods that could sabotage your goals – New York Post

Shes no friend of store-bought blends.

Premade smoothies and cocktails, as well as frozen dinners, should be avoided if youre trying to shed pounds, a Georgia womensweight-loss coach claims.

These foods Im seeing eaten in excess, not moderation, which can make weight loss really difficult, Jenna Rizzo said in a Monday TikTok that has garnered more than 28,200 views.

The American Heart Associationrecommendsconsuming 4 cups offruitevery day but Rizzo says store-bought smoothies and aa bowls arent the way to go.

They are going to be loaded with a bunch of added sugars, and the fruits and vegetables they use are often just a powder, so youre not even eating real food, Rizzo said.

So thats why I say, just make these things at home, she continued. Youre going to be using real food, and youre not going to be adding a cup of sugar to them.

These foods are very calorie-dense, so that means youre only getting a little bit of food for a lot of calories, Rizzo explained. So this can make portion control really hard, because you dont want just a little, tiny slice of pizza, you want three [or] four.

She added: And these foods typically just dont have the best ingredients in them.

Research has linked ultra-processed foods like frozen dinners to a higher risk of premature death, heart disease, colorectal cancer, obesity, depression and other serious conditions.

Consuming alcohol can make it harder to lose weight booze is high in calories and it can interfere with fat burning.

Rizzo calls herself an alcohol hater, especially the premixed cocktails.

You got to think of the juices, the syrups that are added into these cocktails, which will skyrocket the amount of calories, Rizzo said. So you can easily drink hundreds to even thousands of calories in one night. And to add on top of that, I dont know about you, but if I get a little tipsy, I get the drunk munchies really bad.

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Jun 13

Effects of weight loss intervention on anxiety, depression and quality of life in women with severe obesity and polycystic … – Nature.com

Escobar-Morreale, H. F. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat. Rev. Endocrinol. 14(5), 270284 (2018).

Article PubMed Google Scholar

Joham, A. E. et al. Polycystic ovary syndrome. Diabetes 10(9), 668680 (2022).

CAS Google Scholar

Li, Y. et al. Polycystic ovary syndrome is associated with negatively variable impacts on domains of health-related quality of life: Evidence from a meta-analysis. Fertility Sterility 96(2), 452458 (2011).

Article PubMed Google Scholar

Mnsson, M. et al. Women with polycystic ovary syndrome are often depressed or anxiousa case control study. Psychoneuroendocrinology 33(8), 11321138 (2008).

Article PubMed Google Scholar

Cooney, L. G., Lee, I., Sammel, M. D. & Dokras, A. High prevalence of moderate and severe depressive and anxiety symptoms in polycystic ovary syndrome: A systematic review and meta-analysis. Hum. Reprod. (Oxford, England) 32(5), 10751091 (2017).

Article Google Scholar

Cesta, C. E., Mnsson, M., Palm, C., Lichtenstein, P. & Iliadou, A. N. Polycystic ovary syndrome and psychiatric disorders: Co-morbidity and heritability in a nationwide Swedish cohort. Psychoneuroendocrinology 73, 196203 (2016).

Article PubMed Google Scholar

Damone, A. L. et al. Depression, anxiety and perceived stress in women with and without PCOS: A community-based study. Psychol. Med. 49(9), 15101520 (2019).

Article PubMed Google Scholar

Hollinrake, E., Abreu, A., Maifeld, M., Van Voorhis, B. J. & Dokras, A. Increased risk of depressive disorders in women with polycystic ovary syndrome. Fertility Sterility 87(6), 13691376 (2007).

Article PubMed Google Scholar

Hoeger, K. M. Obesity and lifestyle management in polycystic ovary syndrome. Clin. Obstet. Gynecol. 50(1), 277294 (2007).

Article PubMed Google Scholar

Brower, M. A. et al. Bidirectional Mendelian randomization to explore the causal relationships between body mass index and polycystic ovary syndrome. Hum. Reprod. 34(1), 127136 (2019).

Article CAS PubMed Google Scholar

Zhao, Y. et al. Body mass index and polycystic ovary syndrome: A 2-sample bidirectional mendelian randomization study. J. Clin. Endocrinol. Metab. 105(6), 17781784 (2020).

Article Google Scholar

Fontaine, K. R. & Barofsky, I. Obesity and health-related quality of life. Obes. Rev. Off. J. Int. Assoc. Stud. Obes. 2(3), 173182 (2001).

Article CAS Google Scholar

Rajan, T. M. & Menon, V. Psychiatric disorders and obesity: A review of association studies. J. Postgrad. Med. 63(3), 182190 (2017).

Article CAS PubMed PubMed Central Google Scholar

Dokras, A. et al. Androgen excess- polycystic ovary syndrome society: Position statement on depression, anxiety, quality of life, and eating disorders in polycystic ovary syndrome. Fertility Sterility 109(5), 888899 (2018).

Article PubMed Google Scholar

Dokras, A. et al. Weight loss and lowering androgens predict improvements in health-related quality of life in women with PCOS. J. Clin. Endocrinol. Metab. 101(8), 29662974 (2016).

Article CAS PubMed PubMed Central Google Scholar

Moran, L. J. et al. Dietary composition in the treatment of polycystic ovary syndrome: a systematic review to inform evidence-based guidelines. J. Acad. Nutr. Diet 113(4), 520545 (2013).

Article PubMed Google Scholar

Moran, L. J., Pasquali, R., Teede, H. J., Hoeger, K. M. & Norman, R. J. Treatment of obesity in polycystic ovary syndrome: a position statement of the androgen excess and polycystic ovary syndrome society. Fertility Sterility 92(6), 19661982 (2009).

Article PubMed Google Scholar

Kataoka, J. et al. Prevalence of polycystic ovary syndrome in women with severe obesity-effects of a structured weight loss programme. Clin. Endocrinol. (Oxf). 91(6), 750758 (2019).

Article CAS PubMed Google Scholar

Jedel, E. et al. Anxiety and depression symptoms in women with polycystic ovary syndrome compared with controls matched for body mass index. Hum. Reprod. 25(2), 450456 (2010).

Article CAS PubMed Google Scholar

Benrick, A. et al. Autonomic nervous system activation mediates the increase in whole-body glucose uptake in response to electroacupuncture. Faseb 31(8), 32883297 (2017).

Article CAS Google Scholar

Johansson, J. et al. Acupuncture for ovulation induction in polycystic ovary syndrome: a randomized controlled trial. Am. J. Physiol. Endocrinol. Metab. 304(9), E934E943 (2013).

Article CAS PubMed PubMed Central Google Scholar

DA Zawadzki, J. K. Diagnostic Criteria for Polycystic Ovary Syndrome: Towards a Rational Approach. In Polycystic Ovary Syndrome (eds Dunaif, A. et al.) 377384 (Blackwell Scientific, 1992).

Google Scholar

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertility and sterility. 2004;81(1):1925.

Vermeulen, A., Verdonck, L. & Kaufman, J. M. A critical evaluation of simple methods for the estimation of free testosterone in serum. J. Clin. Endocrinol. Metab. 84(10), 36663672 (1999).

Article CAS PubMed Google Scholar

Svanborg, P. & Asberg, M. A new self-rating scale for depression and anxiety states based on the comprehensive psychopathological rating scale. Acta Psychiatr. Scand. 89(1), 2128 (1994).

Article CAS PubMed Google Scholar

Svanborg, P. & Asberg, M. A comparison between the Beck depression inventory (BDI) and the self-rating version of the montgomery asberg depression rating scale (MADRS). J. Affect. Disord. 64(23), 203216 (2001).

Article CAS PubMed Google Scholar

Schulte-van Maaren, Y. W. et al. Reference values for anxiety questionnaires: the Leiden routine outcome monitoring study. J. Affect. Disord. 150(3), 10081018 (2013).

Article PubMed Google Scholar

Lim, S. S. et al. Lifestyle changes in women with polycystic ovary syndrome. Cochrane Database Syst. Rev. 3(3), CD007506 (2019).

PubMed Google Scholar

Schulte-van Maaren, Y. W. et al. Reference values for major depression questionnaires: the Leiden routine outcome monitoring study. J. Affect. Disord. 149(13), 342349 (2013).

Article PubMed Google Scholar

Special issue. Translating functional health and well-being: International Quality of Life Assessment (IQOLA) Project Studies of the SF-36 Health Survey. Issue dedicated to Denis Bucquet. J Clin Epidemiol. 51. United States1998. p. 8911214.

Behboodi Moghadam, Z., Fereidooni, B., Saffari, M. & Montazeri, A. Measures of health-related quality of life in PCOS women: A systematic review. Int. J. Womens Health 10, 397408 (2018).

Article PubMed PubMed Central Google Scholar

Wang, Z. et al. Dietary intake, eating behavior, physical activity, and quality of life in infertile women with PCOS and obesity compared with non-PCOS obese controls. Nutrients 13(10), 3526 (2021).

Article PubMed PubMed Central Google Scholar

Jedel, E. et al. Sex steroids, insulin sensitivity and sympathetic nerve activity in relation to affective symptoms in women with polycystic ovary syndrome. Psychoneuroendocrinology 36(10), 14701479 (2011).

Article CAS PubMed Google Scholar

Weiner, C. L., Primeau, M. & Ehrmann, D. A. Androgens and mood dysfunction in women: Comparison of women with polycystic ovarian syndrome to healthy controls. Psychosom. Med. 66(3), 356362 (2004).

CAS PubMed Google Scholar

van Reedt Dortland, A. K., Giltay, E. J., van Veen, T., Zitman, F. G. & Penninx, B. W. Metabolic syndrome abnormalities are associated with severity of anxiety and depression and with tricyclic antidepressant use. Acta Psychiatr. Scand. 122(1), 3039 (2010).

Article PubMed Google Scholar

Zou, X. H., Sun, L. H., Yang, W., Li, B. J. & Cui, R. J. Potential role of insulin on the pathogenesis of depression. Cell Prolif. 53(5), e12806 (2020).

Article PubMed PubMed Central Google Scholar

Greenwood, E. A. et al. Insulin resistance is associated with depression risk in polycystic ovary syndrome. Fertility Sterility 110(1), 2734 (2018).

Article CAS PubMed Google Scholar

Song, J. Amygdala activity and amygdala-hippocampus connectivity: Metabolic diseases, dementia, and neuropsychiatric issues. Biomed. Pharmacother. 162, 114647 (2023).

Article CAS PubMed Google Scholar

Kleinridders, A. et al. Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. Proc. Natl. Acad. Sci. USA 112(11), 34633468 (2015).

Article ADS CAS PubMed PubMed Central Google Scholar

Toba-Oluboka, T., Vochoskov, K. & Hajek, T. Are the antidepressant effects of insulin-sensitizing medications related to improvements in metabolic markers?. Transl. Psychiatry. 12(1), 469 (2022).

Article CAS PubMed PubMed Central Google Scholar

AlHussain, F. et al. Metformin improves the depression symptoms of women with polycystic ovary syndrome in a lifestyle modification program. Patient Prefer Adher. 14, 737746 (2020).

Article Google Scholar

Hahn, S. et al. Metformin treatment of polycystic ovary syndrome improves health-related quality-of-life, emotional distress and sexuality. Hum. Reprod. 21(7), 19251934 (2006).

Article CAS PubMed Google Scholar

Duan, X., Zhou, M., Zhou, G., Zhu, Q. & Li, W. Effect of metformin on adiponectin in PCOS: A meta-analysis and a systematic review. Eur. J. Obstet. Gynecol. Reprod. Biol. 267, 6167 (2021).

Article CAS PubMed Google Scholar

Kusminski, C. M. et al. Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum. Diabetologia 50(3), 634642 (2007).

Article CAS PubMed Google Scholar

Neumeier, M. et al. Detection of adiponectin in cerebrospinal fluid in humans. Am. J. Physiol. Endocrinol. Metab. 293(4), E965E969 (2007).

Article CAS PubMed Google Scholar

Sullivan M, Karlsson J, Taft C. SF-36 Hlsoenkt: Svensk Manual och tolkningsguide. 2:a upplagan (Swedish Manual and Interpretation Guide, 2nd Edition) ed: Gothenburg: Sahlgrenska University Hospital; 2002.

Glueck, C. J. & Goldenberg, N. Characteristics of obesity in polycystic ovary syndrome: Etiology, treatment, and genetics. Metab Clin. Experimental 92, 108120 (2019).

Article CAS Google Scholar

Gibson-Helm, M., Teede, H., Dunaif, A. & Dokras, A. Delayed diagnosis and a lack of information associated with dissatisfaction in women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 102(2), 604612 (2017).

PubMed Google Scholar

Thomson, R. L. et al. Lifestyle management improves quality of life and depression in overweight and obese women with polycystic ovary syndrome. Fertility Sterility 94(5), 18121816 (2010).

Article PubMed Google Scholar

Wang, Z. et al. Effectiveness of a 6-month lifestyle intervention on diet, physical activity, quality of life, and markers of cardiometabolic health in women with PCOS and obesity and non-PCOS obese controls: One size fits all?. Nutrients 13(10), 3425 (2021).

Article CAS PubMed PubMed Central Google Scholar

Majidzadeh, S., Mirghafourvand, M., Farvareshi, M. & Yavarikia, P. The effect of cognitive behavioral therapy on depression and anxiety of women with polycystic ovary syndrome: a randomized controlled trial. BMC Psychiatry 23(1), 332 (2023).

Article PubMed PubMed Central Google Scholar

Leung, A. W. Y., Chan, R. S. M., Sea, M. M. M. & Woo, J. An overview of factors associated with adherence to lifestyle modification programs for weight management in adults. Int. J. Environ. Res. Public Health 14(8), 922 (2017).

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Jun 13

Measuring Muscle Loss in the Wild West of Weight Loss Drugs – BioSpace

GLP-1 receptor agonists are very effective at helping obese and overweight patients lose weight, but reductions in muscle accompany the fat loss. Mounting evidence suggests muscle loss contributes to poor health outcomes, especially for elderly patients, but clinical trials rarely incorporate the quality of weight lossmuscle vs. fatinto their analyses.

Instead, in obesity, primary trial endpoints for glucan-like peptide-1 (GLP-1) receptor agonists usually measure only reductions in body weight or body mass.

Some drug developers are recognizing that body composition matters. Veru Pharmaceuticals, Regeneron and Altimmune, in clinical trials, and Eli Lilly, in preclinical development, are each working on GLP-1 companion therapeutics that either build or conserve muscle mass.

GLP-1 inhibitors were first shown to lower plasma glucose in 1993, but the attention given to fat-vs.-muscle loss is relatively new. Therefore, the FDA, citing its 2007 draft guidance for industry, Developing Products for Weight Management, still does not recommend using changes in either fat mass or lean mass as endpoints in clinical trials for weight loss drugs. As an FDA spokesperson told BioSpace, To date, we have not identified an adverse clinical impact related to reductions in lean mass.

Others, including Fatima Cody Stanford, associate professor of medicine and pediatrics at Harvard Medical School, writing in JAMA, consider weight loss alone an inaccurate measurement of a medications efficacy. More concerningly, a literature review notes that low muscle mass contributes to a variety of conditions, including mortality.

In managing weight loss, Theres a balance between having good quality weight loss and having a metabolic reset so patients dont have to stay on these therapies for too long, Mayank Mamtani, head of healthcare research at B. Riley Securities, told BioSpace.

Key opinion leaders recognize that, according to Global Data. When interviewed by the industry analyst, they called for changes in the clinical trial design to assess the quality of weight loss so that healthcare providers can better select therapeutic options for their patients. Specifically, they suggested using bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DEXA) scanning to better assess body composition during weight loss.

To ensure that drug-induced weight loss is caused primarily by a reduction in fat mass, the FDA recommends that sponsors . . . conduct an evaluation of body composition . . . in a representative sample of subjects enrolled in the clinical trials, the same FDA spokesperson told BioSpace. DEXA or a suitable alternative is recommended.

However, DEXA and MRI measure lean mass, not muscle mass, Scott Harris, chief medical officer at Altimmune, told BioSpace. Lean mass includes muscle, but it also includes integuments and other soft tissue. MRI can distinguish muscle from lean mass, but the techniques are not universally accepted, so studies usually report out on lean mass instead.

If the trial is not set up with [either DEXA or magnetic resonance imagingMRI] modalities in advance, lean mass and fat mass cannot be assessed, Harris said. Altimmune is developing a dual-action therapeutic, pemvidutide, that, in Phase II trials,reduced appetite and preserved lean muscle mass.

As the FDA notes, weight loss involves the loss of both fat and muscle mass, regardless of whether the loss occurs through pharmacotherapy, bariatric surgery or lifestyle changes.

A reduction in fat-free mass can occur because, with lower fat mass, there is less weight acting on skeletal muscle (leading to reduction in bone and muscle mass), reduced organ size (liver, kidneys and pancreas), and reduced body water weight. These changes in body composition are not considered adverse, the FDA spokesperson reiterated.

So far, the spokesperson continued, Safety data from clinical trials of approved weight loss drugs have not demonstrated adverse effects . . . such as increased incidence of falls, or muscle or tendon injuries, that would be related to loss of lean body mass. Nor have patient-reported outcomes.

But if they arent included among the endpoints, are they being tracked?

The next wave of innovation will be around muscle preservation, Mamtani predicted.

Measuring changes in lean mass is critical for assessing the quality of weight loss, Harris stressed.At Altimmune, we believe the quality of weight loss is as important as the quantity. Thus, we took steps to incorporate this into MOMENTUM, our recently completed Phase II obesity trial.

Additionally, Mamtani called for endpoints to measure weight regain and physical function. Currently, almost two-thirds of the weight lost comes back when patients quit GLP-1 therapies. Likewise, he continued, If youve gone from 250 to 200 pounds, has your quality of life improved?

Several biopharmaceutical companies are building such additional endpoints into their clinical trials for GLP-1 combination therapies.

For example, the percentage change in lean body mass after 112 days is the primary endpoint for Verus Phase II dose-finding study of enobosarm, which conserves muscle mass, combined with GLP-1 receptor agonist semaglutide for weight loss.A series of late-stage trials for enobosarm alone indicates significant improvements in muscle mass compared to placebo.

At Regeneron, a small Phase II study for trevogrumab, which builds muscle mass, was enrolling in March. It will be followed by a larger, four-arm study mid-year to compare outcomes for the combination of trevogrumab and semaglutide. That combination will then be compared to outcomes with or without garetosmab, also developed by Regeneron, which preserves muscle. Primary endpoints include the percent change in both total fat mass and body weight. Secondary endpoints include changes in body weight, lean mass, waist circumference and the total lean mass to fat ratio.

Part C of that trial will evaluate patients weight maintenance and function. Once patients cease taking semaglutide, Roughly half will continue on high-dose trevogrumab to see if the weight can stay off, Ryan Crowe, senior vice president of investor relations and strategic analysis at Regeneron, said at the Barclays Global Healthcare Conference in March. Regeneron did not respond to BioSpaces requests for updates. Qualitative endpoints will include how well people can complete day-to-day tasks, such as a stand-and-sit test, he added. That will probably inform what we do next in terms of measuring functional muscle.

AsMamtani put it, Its the Wild West right now for obesity drugs, and having all this clinical data is going to be important. The future of weight loss drugs may not depend on having the best GLP-1 receptor agonist, he said, but rather a combination of therapeutics that cause weight loss while building or conserving muscle or that improve metabolic health or maintain weight loss.

Almost every serious company in this space is trying to work on that shift, Mamtani said.

Gail Dutton is a freelance science writer who has covered the biopharma industry since soon after its inception. She can be reached at gaildutton@gmail.com. Follow her on LinkedIn or see more of her work on MuckRack.

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Measuring Muscle Loss in the Wild West of Weight Loss Drugs - BioSpace

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Jun 13

Weight loss surgery more effective than obesity drugs: study – New York Post

Sorry, Ozempic users.

Bariatric surgery leads to more weight loss that lasts longer, compared to drugs like Ozempic and Wegovy and behavioral changes such as diet and exercise, new research finds.

Metabolic and bariatric surgery remains the most effective and durable treatment for severe obesity. Unfortunately, it also remains among the most underutilized, said study co-author and bariatric surgeon Dr. Marina Kurian of NYU Langone Health.

Researchers reviewed data from approximately 20,000 weight-loss patients who participated in clinical studies and trials in the last few years.

They found that obesity drugs and weight-loss surgery proved far superior to diet and exercise, which resulted in an average weight loss of 7.4% those pounds were typically regained within four years.

Five months of weekly injections of semaglutide the active ingredient in Ozempic and Wegovy led to a weight loss of 10.6%. These drugs mimic GLP-1 the hormone the body naturally produces after eating to make people feel full, reducing their cravings.

Nine months of tirzepatide sold under the brand names Mounjaro and Zepbound produced weight loss of 21.1%.

But the researchers found that once these treatments stopped, within a year, patients regained about half the weight they had lost.

Tirzepatide patients who continued with the injections tended to plateau at 17 to 18 months with 22.5% of their weight lost. Patients on semaglutide hit a roadblock at 14.9% weight loss during the same period.

Two popular surgical procedures, meanwhile, produced a weight loss around 30% one year after the operation. Patients maintained a 25% weight loss up to 10 years after surgery, the researchers found.

Surgery needs to play a bigger role in obesity treatment and be considered earlier in the disease process, Kurian added. It is no longer a treatment of last resort and should not be withheld until more severe disease develops. There is no medical reason for this.

The research was presented Tuesday at the American Society for Metabolic and Bariatric Surgery 2024 Annual Scientific Meeting.

The society reports that nearly 280,000 weight-loss procedures were performed in the US in 2022, representing only about 1% of those who are eligible for them based on their weight and height.

Gastric bypass and sleeve gastrectomy are two types of weight-loss surgeries that reduce the size of the stomach. Some people may be hesitant to opt for surgery because recovery can take weeks.

There are potential drawbacks to obesity meds as well, including various unpleasant side effects. In a July 2023 survey, 4% of adults admitted to taking a prescription drug to lose weight.

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All the while, obesity rates continue to rise, affectingmore than 42% of Americans, according to the Centers for Disease Control and Prevention.

The serious condition has been shown to weaken the bodys immune system, cause chronic inflammation and increase the risk of cardiovascular disease, stroke, Type 2 diabetes and certain cancers.

A recent study warned that uncontrolled high blood pressure, diabetes and obesity will lead to at least six in 10 US adults being diagnosed with cardiovascular disease within the next 30 years.

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Weight loss surgery more effective than obesity drugs: study - New York Post

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Jun 13

Metabolic surgery proven most effective for sustained weight loss over GLP-1 drugs and lifestyle interventions – News-Medical.Net

Systematic reviewsof medical literature between 2020 to 2024 show bariatric surgery, also known as metabolic or weight-loss surgery, produces the greatest and most sustained weight loss compared to GLP-1 receptor agonists and lifestyle interventions. The study was presented today at the American Society for Metabolic and Bariatric Surgery (ASMBS) 2024 Annual Scientific Meeting.

Researchers found lifestyle interventions such as diet and exercise resulted in an average weight loss of 7.4% but that weight was generally regained within 4.1 years. GLP-1s and metabolic and bariatric surgery proved far superior. Studies included thousands of patients from clinical studies and several randomized clinical trials.

Five months of weekly injections of GLP-1 semaglutide resulted in 10.6% weight loss and nine months of tirzepatide produced 21.1% weight loss. However, once treatment stopped, about half the lost weight returned within a year despite which drug was used. If injections were continued, tirzepatide patients plateaued at 22.5% weight loss at 17-18 months. Patients on semaglutide plateaued at 14.9% during the same time period.

Metabolic and bariatric surgery procedures gastric bypass and sleeve gastrectomy demonstrated total weight loss of 31.9% and 29.5% one year after surgery, respectively. Weight loss of approximately 25% was maintained for up to 10 years after surgery.

"Metabolic and bariatric surgery remains the most effective and durable treatment for severe obesity. Unfortunately, it also remains among the most underutilized," said study co-author and bariatric surgeon Marina Kurian MD, NYU Langone Health. "Surgery needs to play a bigger role in obesity treatment and be considered earlier in the disease process. It is no longer a treatment of last resort and should not be withheld until more severe disease develops. There is no medical reason for this."

The ASMBS reports that in 2022 nearly 280,000 metabolic and bariatric procedures were performed in the U.S., which represents only about 1% of those who meet eligibility requirements based on BMI. According to the U.S. Centers for Disease Control and Prevention (CDC), obesity effects42.4% of Americans. Studies show the disease can weaken or impair the body's immune system and cause chronic inflammation and increase the risk of many other diseases and conditions including cardiovascular disease, stroke, type 2 diabetes, and certain cancers.

"While the new drug treatments show great promise and will lead to more people being successfully treated, particularly if prices come down and insurance coverage improves, we are barely using the best tool we have to fight obesity -- metabolic and bariatric surgery, which is safer and more effective than ever before," said Ann Rogers, MD, ASMBS President-elect and Professor of Surgery at Penn State College of Medicine, who was not involved in the study. "For many people, the risk of death from obesity, diabetes, and heart disease exceeds the risks of surgery."

The study included a systematic review of studies that examined weight loss through lifestyle modification, GLP-1s (Semaglutide or tirzepatide) or metabolic and bariatric surgery. GLP-1 data included four randomized clinical trials conducted between 2021 and 2024 while conclusions on lifestyle modifications were based on a systematic review of eight studies. Metabolic and bariatric surgery (gastric bypass and sleeve gastrectomy) were subject to a review of 35 studies, including two randomized clinical trials. In all, researchers reviewed the weight-loss results of approximately 20,000 patients.

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Metabolic surgery proven most effective for sustained weight loss over GLP-1 drugs and lifestyle interventions - News-Medical.Net

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Jun 13

Jon Gosselin Shares Beach Body Transformation Amid Weight Loss Journey – E! NEWS

Well aware that she's hot in Cleveland, L.A. or wherever else she happens to be, the actress gave her refreshing take on body image with a February Instagram post.

"This is a 150lb body on a 5'4 frame," the Food Network host wrote, sharing a 2014 bikini photo. "I don't weigh myself anymore because this is considered overweight by who's [sic] standards, I don't know. It's stupid and I believed them for far too long."

Fully removed from the pressures of dieting, "I now, finally, know that I am a kind, considerate, funny, thoughtful woman," she continued. "So please remember, who you are and what your character is, should never be overshadowed by what size you are or how much you weigh. You are enough. Just the way you are."

As for anyone that might not agree, she summed up, "F--k em."

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Jon Gosselin Shares Beach Body Transformation Amid Weight Loss Journey - E! NEWS

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Jun 13

Timothy Law: GLP-1 Drugs Changed the Paradigm in Weight Loss | AHIP 2024 – Managed Healthcare Executive

Drugs like Wegovy and Zepbound are not a panacea for those people looking for a quick fix, Timothy Law, DO, MBA, chief medical officer of Highmark Inc., said in an interview with Managed Healthcare Executive before the annual AHIP meeting in Las Vegas. Law along with panelists Melanie R. Jay, M.D., director of NYU Langone Comprehensive Program on Obesity Research, and Amy Meister, D.O., chief medical officer of WeightWatchers, is speaking about how GLP-1 therapies are changing how the healthcare industry views prevention and treatment.

Highmark is an independent licensee of the Blue Cross Blue Shield Association about 7 million members in Pennsylvania, Delaware, New York and West Virginia.

Here Law talks about what GLP-1 agonist drugs like Wegovy (semaglutide) and Zepbound (tirzepatide) can do and the important of lifestyle management

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Timothy Law: GLP-1 Drugs Changed the Paradigm in Weight Loss | AHIP 2024 - Managed Healthcare Executive

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Jun 13

Weight loss boom is spurring sales of protein, meal replacement products, Vitamin Shoppe CEO says – NBC San Diego

L.L. Bean has just added a third shift at its factory in Brunswick, Maine, in an attempt to keep up with demand for its iconic boot.

Orders have quadrupled in the past few years as the boots have become more popular among a younger, more urban crowd.

The company says it saw the trend coming and tried to prepare, but orders outpaced projections. They expect to sell 450,000 pairs of boots in 2014.

People hoping to have the boots in time for Christmas are likely going to be disappointed. The bootsare back ordered through February and even March.

"I've been told it's a good problem to have but I"m disappointed that customers not getting what they want as quickly as they want," said Senior Manufacturing Manager Royce Haines.

Customers like, Mary Clifford, tried to order boots on line, but they were back ordered until January.

"I was very surprised this is what they are known for and at Christmas time you can't get them when you need them," said Clifford.

People who do have boots are trying to capitalize on the shortage and are selling them on Ebay at a much higher cost.

L.L. Bean says it has hired dozens of new boot makers, but it takes up to six months to train someone to make a boot.

The company has also spent a million dollars on new equipment to try and keep pace with demand.

Some customers are having luck at the retail stores. They have a separate inventory, and while sizes are limited, those stores have boots on the shelves.

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Weight loss boom is spurring sales of protein, meal replacement products, Vitamin Shoppe CEO says - NBC San Diego

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