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Shares of Eli Lilly (LLY) gained in intraday trading Wednesday after the pharmaceutical firm said a late-stage study found its weight-loss drug, Zepbound, was effective in treating those who are overweight and suffer from obstructive sleep apnea (OSA).

The company said that in a Phase 3 trial, on average, Zepbound reduced by up to 63% the apnea-hypopnea index (AHI) in the test group, achieving all primary and key secondary endpoints. AHI records the number of times a person's breathing shows a restricted or complete block of airflow per hour of sleep, and is used to measure the severity of OSA. Lilly pointed out that at the top end of the findings, use of Zepbound cut the number of events by 30 an hour.

Dr. Jeff Emmick, senior vice president of development at Lilly, explained that OSA affects 80 million adults in the U.S., with more than 20 million having moderate or severe cases. He added that while other drugs for excessive sleeplessness associated with OSA now exist, Zepbound has the potential to be the first pharmaceutical treatment for the underlying disease.

Lilly noted that based on these results, it plans to submit authorization requests for expanded use of Zepbound for OSA to the Food and Drug Administration (FDA) and other global regulatory bodies beginning in the middle of the year.

Zepbound is sold as Mounjaroin some global markets outside theU.S.

Eli Lilly shares rose 0.5% to $750.30 each as of noon ET Wednesday and have added almost 27% so far this year. The news sent shares of ResMed (RMD), which makes devices to treat sleep apnea, down 6% to $173.39.

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While Charles qualified for weight loss surgery, he declined the offer, claiming he didn't want to move to Houston and leave his family.

TLC's My 600-lb Life highlights the weight loss attempts of severely obese individuals across the country as they work with esteemed bariatric surgeon Dr. Now.

The individuals the show features all have one thing in common: They're addicted to food and the feeling it gives them.

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During the Season 12 finale, we meet Charles Bridgeman from Everett, Wash., who knows all about grappling with a life-threatening addiction. While food was always a comfort for him, he was addicted to meth for a decade. His addiction prompted his mom and grandma to kick him out, leaving him homeless for quite some time and even resulting in him getting arrested.

Fortunately, Charles went to rehab and got clean a few years back. But this shining achievement was eclipsed by the fact that he seemed to have replaced drugs with food.

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When we meet Charles, who is in his early 30s, he is living with his brother, Brad, and sister, Cheyana. Brad's full-time job has become taking care of Charles, who cannot make himself food and can only walk a few steps at a time before needing to rest.

Charles's journey on My 600-lb Life was an interesting one. He and Dr. Now butted heads several times and Charles often didn't follow Dr. Now's directions. Usually, when this happens on the show, the individual ends up gaining weight and getting farther away from their goal.

However, Charles did lose weight, and Dr. Now did end up approving him for weight loss surgery. But Charles had seemingly gotten so comfortable at home with Brad, who kept him on track, that he declined the offer. He said didn't want to move to Houston for the surgery and leave his family, even if it was only temporary.

At the end of the episode, Charles said he wanted to continue his weight loss efforts in Everett and possibly reconsider surgery in the future. That said, where is Charles now? Did he ever get bariatric surgery, and was he able to continue losing weight on his own?

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Charles and his brother Brad in Dr. Now's office in Houston, Texas

Since his time on My 600-lb Life, Charles appears to be doing very well. According to his Facebook profile, he is still living in Everett, Wash., and has continued to lose weight.

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Charles has been spending time with his dogs and recently took them to the dog park, illustrating that he's still making an effort to go outside and do more activities.

However, the biggest update is Charles's current weight. At the beginning of his episode, he was believed to be over 700 pounds. After adopting Dr. Now's diet plan and developing an exercise routine, he was down to 604 pounds by the end of the episode, losing well over 100 pounds on his journey.

That being said, in September 2023, Charles revealed some exciting news: "Omg down to 385," he wrote on Facebook.

It's unclear if this substantial weight loss was strictly from dieting or if Charles did get bariatric surgery, which would likely expedite his weight loss. However, we are glad to hear that Charles hasn't given up and is continuing to lose weight.

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Where Is Charles Bridgeman From 'My 600-lb Life' Now? He's Lost a Significant Amount of Weight - Distractify

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Tori Spelling revealed that she took type 2 diabetes drug Mounjaro for weight loss.

On the April 16 episode of her podcast misSPELLING, the Beverly Hills, 90210 star, 50, discussed her decision to try Mounjaro, an FDA-approved prescription medication for people with type 2 diabetes. It's a brand name for tirzepatide also known as Zepbound which has been proven to be highly effective for weight loss by reducing appetite and improving how the body breaks down sugar and fat.

Mounjaro is similar to Ozempic and Wegovy brand names for semaglutide which work in the brain to impact satiety, and have been trending in Hollywood circles for weight loss.

I did Mounjaro and everyone admits it now. Its a different time so I dont feel shamed saying that, Spelling said on the show.

The actress said took the drug in order to lose her baby weight. She said shes really fortunate because she was able to lose her baby weight after giving birth to four of her children, praising her good genes from her thin parents.

However, Spelling admitted that she struggled to lose weight after welcoming her fifth child, son Beau, back in 2017. I couldnt lose the weight, she explained. At my heaviest, I was 120 lbs. my entire life. And after Beau, I was 160 lbs.

I couldnt lose the weight and the doctor was like, Well, its an age thing, added Spelling, who had Beau at age 44.

Rodin Eckenroth/FilmMagic

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Although Spelling said she never works out and hates drinking water, she said she tried everything to lose weight including exercising and intermittent fasting.

I did whatever anyone told me to do that was safe and it just wasnt working, she said. The weight wouldnt come off.

Spelling said she then visited her doctor who prescribed her to Mounjaro, in addition to hormones as she was approaching menopause.

She put me simultaneously with the hormones on Mounjaro, she said. Im no longer on it but I did lose weight and I havent been on it since the end of January.

In addition to Spelling, other stars have shared their experiences using Mounjaro including Tracy Tutor, Dolores Catania, Gracie McGraw, Boy George, Whoopi Goldberg and Lauren Manzo.

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Tori Spelling Took Mounjaro to Lose Her Baby Weight - PEOPLE

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KRIS Jenner has been seen in a new promotional video, and she looked incredibly thin.

Kris, 68, took part in an advertisement for Safely, a cleaning product company co-founded by the momager.

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In the clip, she discussed the brand's new Spring Cleaning Challenge where followers can win free cleaning supplies.

She wore a bright pink blazer with double buttons and three-dimensional floral details.

Under the blazer, she rocked a turtleneck in the same bright pink color.

The jacket cinched her waist to flaunt her recent weight loss and show off her tiny frame.

The Kardashian was standing in a luxurious kitchen filled with copper pots and pans and Safely products.

This wasn't the first time the Hulu personality has garnered attention based on her weight loss.

On Tuesday, she appeared with her boyfriendCorey Gamble, 43, while wearing head-to-toe designer clothing.

In the comment section of that post, her daughter Khloe Kardashian, 39, wrote, "Mom you are so so stunning."

Fans also complimented Kris on her appearance, but others grew concerned for the television star.

Some thought her photos were an "Ozempic commercial" as social media users attributed her new figure to the Type 2 Diabetes drug.

One fan begged her to "please be careful" as they warned her about the possible side effects of the prescription drug.

She also sported yoga clothing from the brand Alo including super tight leggings that clung to her thin legs.

On Reddit, fans saw the Alo photos and claimed that watching her lose weight was "getting scary."

These photos also prompted fans to believe that Kris has been taking Ozempic.

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Kris sparked more concern at the beginning of the month when her appearance shocked fans.

She was filming a TikTokwith her daughterKim Kardashian, 43, andgranddaughter North West, 10.

The clip was from Easter and included afun danceto a musical number fromthe movie Wonka.

Kris' fans immediately zoomed in on her face while noticing that her features seemed softer than usual.

One user on Reddit even asked if she was "melting" while sharing a screenshot from the video.

Another asked what was going on with her makeup and jokingly said she was melting like the Wicked Witch of the West because it was raining in Southern California.

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Not all

The meal plan was created by entrepreneur and podcaster Timothy Ferriss, author of The 4-Hour Body: An Uncommon Guide to Rapid Fat Loss, Incredible Sex, and Becoming Superhuman. In his 2010 book, Ferriss outlines his trademarked slow-carb diet which involves eating meat with legumes and vegetables for almost every meal of the day and swapping refined carbs with slow carbs AKA ones that take longer to digest.

Although slow carb isn't an official nutrition term, the trendy diet remains popular for weight loss. But what can you eat on a slow-carb diet, and is it actually safe to try? Here are the benefits, risks, foods list, and things to keep in mind when trying it for yourself, according to a registered dietitian.

Meet the expert: Brigitte Zeitlin, is a registered dietitian and owner of BZ Nutrition in New York City.

First, what is a slow carb? The phrase relates to the concept of simple versus complex carbs: Simple carbohydrates move through the body at a faster pace than complex ones such as legumes or dark leafy greens, says Brigitte Zeitlin, a registered dietitian and owner of BZ Nutrition in New York City. Simple carbs end up being less filling and satiating plus, they spike your blood sugar compared to complex ones due to the removed fibre. In short: complex carbs = slow carbs.

The slow-carb diet involves eating five main food groups (animal protein, vegetables, legumes, fats, and spices) across four meals a day for six days of the week, and focusing on carbs that take longer to digest. You get one free day per week on which you can eat whatever you want, Zeitlin says.

The idea is to follow a very low-carb regimen on the premise that it will increase your bodys ability to break down fat for energy and reduce your overall fat stores, Zeitlin says and in turn, reduce your body weight. By following the slow-carb diet, you might be able to lose 10-20 pounds (4-9kg) in one month even without exercising, per the founder's website. You're also welcome to take various supplements (like calcium and magnesium) while doing the diet, but they aren't a requirement, per the website.

The slow-carb diet is based on the following five fundamental rules, per the founder:

If you are on this diet to lose weight, then you need to avoid all processed carbohydrates (like breads, pastas, cereals, baked goods, etc) for six days per week. If you are on the diet to increase your muscle and strength, then youre allowed to eat these foods within 30 minutes of finishing a resistance-training workout.

The slow-carb diet encourages you to re-make the same meals from the approved five groups of foods (animal protein, vegetables, legumes, fats, and spices). That said, eating a variety of different foods boosts your health and helps you manage your weight, per the CDC so while it's helpful to stick to a few weight loss-friendly foods, don't feel like you have to restrict yourself entirely.

The slow-carb diet boasts the importance of drinking water and other unsweetened tea or coffee drinks. Consuming alcohol, juice, smoothies, or any calorie-filled beverage is discouraged. (If you love a treat and can't stay away, try a low-calorie cocktail or healthy smoothie that will satisfy your sweet tooth and support your health goals.)

This diet bans all fruit intake on the premise that they contain too much sugar for weight loss. However, it's worth noting that many experts still recommend fruit on a weight loss plan.

Based on the slow-carb diet guidelines, you can eat and drink anything you wish on one day per week of your choosing. You may have heard this called a cheat day, but we prefer taking a break. Enjoy yummy foods and make note of how your body feels you even may find that your new routine has changed how you view healthy, satiating meals.

The diet is based on five main food groups: protein, legumes, vegetables, fats, and spices. The founder recommends eating these exact foods over and over without adding new options but of course, no diet is one-size-fits-all, and you're encouraged to find nourishing foods that work for you and your lifestyle. In the meantime, here are the suggested foods for the slow-carb diet:

One of the main rules of the diet is that you're encouraged eat the same things over and over to get you in a routine a variety of meals is not necessarily the goal or purpose here. The following are a few examples of meals you could enjoy that fit the slow-carb diet bill, according to Zeitlin:

The diet cuts out processed foods, sugary beverages, and other less-nutritious foods, and doing so can certainly yield weight loss results. Allowing for a day of eating whatever you want may help some people feel less deprived, too. (However, the opposite can also be argued).

The online reviews about the slow-carb diet are mixed, but there are certainly lots of positive ones. Even if you don't actually apply any of the techniques, this book will likely make you think about your overall health in a different way, one reviewer wrote on Amazon. There is a wealth of information in this book, and it has helped me lose weight, gain strength, and run faster in the last 12 months.

The same reviewer went on to explain: Like most of Ferriss' work, it could easily be misunderstood. Be clear that it isn't about shortcuts or 'hacks' it's about efficiently getting maximum benefit from the minimum input but that 'minimum input' still requires effort and dedication. You'll get out what you're prepared to put in. (That's only *one* person's opinion, of course, but valid points.)

There are very few pros to fad, restrictive diets like this one, according to Zeitlin. You can definitely lose weight, but she warns it may not be sustainable for everyone. As soon as you reintroduce the healthy food groups that have been removed, like whole grains and fruits, you will regain weight and likely gain back more weight than you originally lost, Zeitlin says.

Zeitlin also warns that you may feel guilty about falling off the plan, and you may end up going overboard on the restricted foods if you feel deprived while omitting simple carbs, alcohol, and more six days of the week. Additionally, the concept of a free or "cheat" day can create a messed-up relationship with food, reinforcing the notion that they are 'good' foods and 'bad' foods, when some of those 'bad' foods are vitamin-rich fruits and whole grains, she adds.

The choice is ultimately yours, and you know your body and personality best. Some people have an easier time losing weight by following structured guidelines and strict shopping lists, while others (like people with a history of disordered eating) may find that type of heavy guidance and rigidity harmful or even downright dangerous.

Zeitlin personally doesnt recommend trying an overly restrictive diet like the slow-carb diet. Diets that encourage cutting food groups out completely dont support your health goals long-term and can leave you yo-yo-ing up and down with your weight, she says.

If you are trying to lose weight, Zeitlin recommends concentrating on foods you should be adding in versus taking out, she says. This includes adding in more veggies, lean proteins, whole grains instead of white flour, and fruits. Keep your grains and fruits to two servings each per day and dont forget to add in more water, along with sleep and physical activity, she says.

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It's no secret that intermittent fasting has been having a moment (well, more than a moment) for a few years now. Proponents of the diet strategy swear intermittent fasting can have a slew of different health benefits, from reseting your relationship with food to weight loss. But it can be tricky to figure out what foods and drinks to consume after fasting (and how many calories actually break a fast).

For example, during a fasting window, can you have coffee and tea? What about healthy snacks? Is there some kind of calorie limit here? Also, whats the best thing to eat and drink when youre ready to break your fast?

So many questions. But dont stressdietitians have answers about what does (and doesn't) break a fast. Here's everything you need to know.

Meet the experts: Scott Keatley, RD, is a dietitian at Keatley Medical Nutrition Therapy. Jessica Cording, RD, is a dietitian and author of The Little Book of Game-Changers.

Intermittent fasting focuses on following a particular pattern of eating and fastingessentially, times when you eat and dont eat. Intermittent fasting usually involves limiting eating and drinking for a certain number of hours, or even days, that are spaced out during the week.

There are plenty of types of intermittent fasting schedules to choose from. One of the most popular versions is the 16:8 diet, where you fast for 16 hours a day and eat only during eight hours (most people tend to stop eating at a certain time in the evening, like 6 p.m., and then wait to eat again until 16 hours later). There's also the 5:2 diet, where you eat less than 500 calories for two non-consecutive days a week (for men, its less than 600 calories) and eat normally for the rest of the time.

Intermittent fasting has been linked to lower insulin levels and blood pressure along with increased appetite control. Some people also claim to lose weight while intermittent fasting.

Technically, fasting means refraining from having any kind of foodso, as a result, any amount of calories will technically break a fast, says dietitian Scott Keatley, RD, of Keatley Medical Nutrition Therapy. The rule of thumb floating around the internet is that 50 calories will break your fast, but this is based on one random guy's experience and has been repeated so often that people believe it's true, he says.

Theres unfortunately no hard-and-fast rule (or research) providing the set number of calories that are okay for fasting, says dietitian Jessica Cording, RD, author of The Little Book of Game-Changers. Plus, everyones metabolism is different, so what jumpstarts you out of a fast may be different from what does the same for your friend, she notes.

As soon as you consume enough calories to give your body energy to do anything, that brings you out of that fasting state because your body has been given fuel to work with, Cording says. Basically, having any amount of calories means you're rolling the dice with leaving your fasting state.

Again, fasting by definition means youre not having food for a period of time. That said, some intermittent fasting schedules allow you to consume low-calorie beverages. Here's what you can drink while fasting:

Water. Water is fine, for sure, Keatley says. This includes still or sparkling water, although flavored waters get a little dicey because they usually contain some calories.

Coffee. Black coffee has about five calories per cup, which is technically not nothing, Keatley points out. Still, he says, most people have black coffee during fasting periods and do just fine. Just skip add-ons like milk, creamer, or sugar. That will have an effect on your fast, Cording says.

Tea. Brewed tea typically contains the same calories as a cup of black coffee or less. The same rules apply here as they do for coffee, Cording says.

Some people will drink chicken broth or bone broth, or add MCT oil, ghee, or coconut oil to their coffee during a fast, but all of these can technically "break" your fast, Cording notes. Foods like bone broth, specifically, have plenty of protein. What can happen is, when you consume the broth, your body uses the amino acids as fuel and then youre not longer in the fasting state, she says.

Time to break your fast? Experts recommend approaching this phase gently and choosing your foods and beverages wisely. Eating a bunch of food thats high in carbs and sugar in a short period of time wont make you feel great, Cording says. If you drop a big load of carbohydrates into your bloodstream on an empty stomach, youre going to feel uncomfortable, she says. It could set you up for glycemic instability throughout the day, causing problems with energy levels and appetite control. It could work against you.

Its easy to overeat when you break a fast (because, hello, you're hungry!), but planning out what youll do when you eat again can help. If you're going to give this diet a try, plan, plan, plan, and cater it to your life, Keatley says.

Cording recommends starting with something on the smaller side that also has a good amount of fat, like nuts and seeds, which she calls a good starting place. For example, you can have a handful of almonds while you make a bigger meal to ease your stomach into eating again.

Since you only have so much time in your day to fit in healthy foods, Keatley says it's best to focus on nutritious options. I would recommend a complete protein that has healthy fats and is loaded with vitamins and minerals, like eggs, he says. You still need to get about 25 to 35 grams of fiber in your system, so having high-fiber products as well such as beans, legumes, and anything ending in '-berry' should be on the plate. Healthy oils like avocado and olive oil can also give you energy, he says.

You should also "give yourself a few hours break and go again with the same formula but different foods," Keatley says.

This is slightly tricky. Vitamins and minerals have no calories in themit's the stuff companies put with the vitamins that have calories, Keatley says. Usually salt, potassium, and various sugars are used to bind with the vitamins and minerals as a delivery system, he says, adding that reviewing the ingredient list on your multivitamin is the only way to know for sure. In general, most vitamins have between seven to 10 calories each, although gummies have more due to their sugar content, Keatley says.

Theres also this to consider: If youre taking a fat soluble vitamin like vitamin D, youll really want to have it with food, because its absorbed better in your body with fat, Cording points out. Overall, its better to try to take supplements during your non-fasting state, just to be safe, Cording says.

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A rescue cat in Indiana is swimming his way toward his goal weight!

Tyaffectionately nicknamed "Thicken Nugget"was surrendered to the Vanderburgh Humane Society in January. When he arrived, the shelter staff was shocked that the feline weighed 30 lbs.

"We had quite the surprise," staff member Mackenzee McKittrick told the local outlet Tristate Homepage about the moment the shelter first met Ty.

Vanderburgh Humane Society/Facebook

While the ideal weight for cats varies based on breed and sex, a male house cat should generally weigh between 11-15 lbs., according to Purina. Ty weighed twice the average when he was surrendered, which led the shelter to formulate a unique exercise plan for the orange cat: swimming.

The shelter raised money for Ty's water therapy, which takes place twice weekly at the Canine Aquatic Center, according to Facebook. At first, the cat wasn't a fan of lessons, but in an April 3 update posted by Vanderburgh Humane Society, it was revealed all of Ty's hard work is paying off.

"Remember Ty? He is well on his way to reaching his goal weight, thanks to everyone who donated towards his water therapy at Canine Aquatic Center! ," the shelter wrote alongside photos featuring the kitty in a pool and on land. "He is swimming twice a week, is much more mobile and down from 30 pounds to 26.8 He's even swimming across the pool all by himself Go Ty, go!"

The Canine Aquatic Center also shared an update on Facebook, including videos of Ty swimming across the pool in his little life vest. In the post, the center shared that the "chonky cat" who "so famously" protested against his first pool session is now "quite the swimmer."

"Well look at this sweet boy now! He is quite the swimmer!!," the post read. "It took time and reassurance (note the ledge pep talks) but this guy is quite the trooper and does not fuss or fight and is swimming across the pool by himself. He has lost 3+ pounds since being surrendered and his care team will keep working hard to help him so he can have a long, happy and healthy life."

As adorable as Ty is now, the extra weight impacts his quality of life, which is why the shelter hopes to help him lose around 15 lbs before finding him a forever home.

McKittrick and volunteers at the shelter told local station WEHT that the cat's size had impacted his joints and, if left unchecked, could cause spinal damage.

"A lot of people think it's cute when it's like that Garfield-type cat, but it's not cute," McKittrick said. "Ty's quality of life is affected at this point, so we want to give him a good quality of life, and we know that the adoptive home is going to adhere to his diet and exercise restrictions."

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Thankfully, Ty has taken to the water.

Canine Aquatic Center/Facebook

"Day one, he didn't know he could swim, and he had a little bit more weight on him," canine therapist (and Ty's frequent swim instructor) Laura Novack told Tristate Homepage before adding. "He's swimming really well."

McKittrick has noticed a positive change, too. These days, "Thicken Nugget" is "definitely more mobile," she told the outlet.

"He's moving around the clinic now more, which is just going to expedite his weight loss."

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Rescue Cat Nicknamed 'Thicken Nugget' Takes Up Swimming to Help Him Shed Extra Weight - PEOPLE

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Summary

Tammy Slaton from 1000-Lb Sisters shows how far she has come in her weight loss journey. The Kentucky native weighed nearly 700 pounds a handful of years ago. Tammy wasnt just morbidly obese but also struggled with mental health issues such as food addiction. In 2022, Tammy faced a major health scare due to her breathing issues. The doctor put her into a medically-induced coma, which became a wake-up call for her and inspired her to change her lifestyle dramatically. Tammy lost over 400 pounds after undergoing bariatric surgery and transformed herself for the better.

Recently, Tammy shared a TikTok photo gallery highlighting her weight loss transformation. She compared her new look to how she looked a few years ago, showing fans how far she has come. In one photo, Tammy sported a pink sweater and gray skirt. In another, she stood beside her car wearing a black sleeveless top and denim overalls. The 1000-Lb Sisters star looked better than ever in the post, and her older photos highlighted her praiseworthy weight loss achievement. The audio clip that played over the gallery was a quote from JoJo Siwa, who said, No one has made this dramatic of a change yet.

Tammys weight loss has helped her become a better person in many ways. She has become far more confident about herself and gained a positive outlook. Her latest photos prove that shes healthy now and much happier. Tammy is experimenting with fashion, trying out new outfits, and traveling outdoors. She also doesnt rely on others to help her with things now. Tammy finally has her life back in control after struggling for decades. She has worked hard to lose weight, making her the best version of herself within just two years.

While Tammy has always been confident enough to be in front of the cameras, she has also been insecure about her size. To make matters worse, critics have further harassed her by calling her names or posting negative comments. Fortunately, the weight loss has helped Tammy become more self-assured. She no longer cares if critics make fun of her. Tammy is proud of her impressive weight loss transformation. She has made her supporters and family members happy by improving her life. She has shown that anything is possible, regardless of how tough the circumstances are.

It makes sense why Tammy used JoJos quote with her video. She relates to the singers words because theyre about dramatic change. A few years ago, it didn't seem like Tammy was going to change herself. She was considered a spoiled brat who might never fix her life, like Amy Slaton did. However, Tammy proved everyone wrong. She showed that she had what it took to make the dramatic switch. The 1000-Lb Sisters star is one of a kind in her generation, and nobody has achieved what she has in such a short time in front of millions of spectators.

1000-Lb Sisters seasons 1-5 can be streamed on Discovery Plus.

Source: Tammy Slaton/TikTok

1000-lb Sisters follows sisters Amy Salton-Halterman and Tammy Slaton in their home in Dixon, Kentucky, covering their daily lives, weight loss attempts, and subsequent weight loss surgery. The show covers such moments as attempts to have children, medical visits, and dramatic emergency room visitations. The family wrestles with supporting their daughters and their weight loss efforts while struggling with their own life troubles.

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