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Apr 25

The Global Testosterone Replacement Therapy Market is forecast to grow by $439.67 mn during 2022-2027, accelerating at a CAGR of 3.38% during the…


Global Testosterone Replacement Therapy Market 2023-2027. The analyst has been monitoring the testosterone replacement therapy market and is forecast to grow by $439.67 mn during 2022-2027, accelerating at a CAGR of 3.38% during the forecast period.

New York, April 18, 2023 (GLOBE NEWSWIRE) -- announces the release of the report "Global Testosterone Replacement Therapy Market 2023-2027" - Our report on the testosterone replacement therapy market provides a holistic analysis, market size and forecast, trends, growth drivers, and challenges, as well as vendor analysis covering around 25 vendors.The report offers an up-to-date analysis regarding the current market scenario, the latest trends and drivers, and the overall market environment. The market is driven by initiatives to increase awareness about hypogonadism among the population, rise in chronic diseases, and increasing aging population and postmenopausal women.

The testosterone replacement therapy market is segmented as below:By Distribution Channel Hospitals Retail Online

By Product Injectables Topicals Others

By Geographical Landscape North America Europe Asia Rest of World (ROW)

This study identifies the rise in novel therapeutic approaches as one of the prime reasons driving the testosterone replacement therapy market growth during the next few years. Also, patient assistance programs and growing new developments in the market will lead to sizable demand in the market.

The analyst presents a detailed picture of the market by the way of study, synthesis, and summation of data from multiple sources by an analysis of key parameters. Our report on the testosterone replacement therapy market covers the following areas: Testosterone replacement therapy market sizing Testosterone replacement therapy market forecast Testosterone replacement therapy market industry analysis

This robust vendor analysis is designed to help clients improve their market position, and in line with this, this report provides a detailed analysis of several leading testosterone replacement therapy market vendors that include AbbVie Inc., Acerus Pharmaceuticals Corp., Acrux Ltd., Actiza Pharmaceutical Pvt. Ltd., Alembic Pharmaceuticals Ltd., Alvogen Iceland ehf, Amneal Pharmaceuticals Inc., Antares Pharma Inc., Bausch Health Co. Inc., Bayer AG, Cipla Ltd., Eli Lilly and Co., Endo International Plc, Ferring BV, Halozyme Therapeutics Inc., Insud Pharma S.L, Lupin Ltd., Marius Pharmaceuticals, Pfizer Inc., Sawai Pharmaceutical Co. Ltd., and Teva Pharmaceutical Industries Ltd. Also, the testosterone replacement therapy market analysis report includes information on upcoming trends and challenges that will influence market growth. This is to help companies strategize and leverage all forthcoming growth opportunities.The study was conducted using an objective combination of primary and secondary information including inputs from key participants in the industry. The report contains a comprehensive market and vendor landscape in addition to an analysis of the key vendors.

The analyst presents a detailed picture of the market by the way of study, synthesis, and summation of data from multiple sources by an analysis of key parameters such as profit, pricing, competition, and promotions. It presents various market facets by identifying the key industry influencers. The data presented is comprehensive, reliable, and a result of extensive research - both primary and secondary. Technavios market research reports provide a complete competitive landscape and an in-depth vendor selection methodology and analysis using qualitative and quantitative research to forecast accurate market growth.Read the full report:

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.


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The Global Testosterone Replacement Therapy Market is forecast to grow by $439.67 mn during 2022-2027, accelerating at a CAGR of 3.38% during the...

Apr 25

Could wearing a testosterone patch reignite women’s sex drive … – The Irish News

Many think of testosterone as just a male sex hormone, but it is very important for women, too.

It plays a part in maintaining a womans libido and energy levels, improves mood, sleep and keeping bones healthy. In women, testosterone is produced in the ovaries and adrenal glands (whereas in men it is produced in the testes).

"Levels peak in women in their mid-20s and start to decline from the 30s onwards," says Dr Haitham Hamoda, a consultant gynaecologist and menopause lead at Kings College Hospital, London, and immediate past chair of the British Menopause Society.

"However, unless a woman is experiencing symptoms of low sex drive that doesnt improve with oestrogen treatment, we wouldnt check her testosterone levels."

There is no "normal" testosterone level for women, but in general they "have about a tenth of the levels of testosterone that men have", explains Dr Hamoda.

It can cause a low sex drive in some women and this is a common symptom of the menopause.

However, not all menopausal women experience this and low sex drive can be linked to other factors including illness, medication and relationship problems.

Testosterone is a treatment approved by the National Institute for Health and Care Excellence for women with low libido if HRT doesnt alleviate the problem.

"For a significant proportion of women going through the menopause, testosterone does have a beneficial effect on sex drive," says Dr Hamoda.

"However, we dont yet know whether testosterone also has a beneficial effect on energy levels, mood, sleep and bone health and it is not approved to treat these problems. Further research is needed to evaluate this."

There is currently no licensed testosterone product specifically for women in the UK. There are three testosterone gels licensed for men Tostran, Testim and Testogel which are rubbed onto the skin daily. These can be prescribed to women with low libido both on the NHS and privately supervised by a specialist and prescribed by a GP.

However, access to the treatment can be sketchy because some NHS GPs are uncomfortable or reluctant to prescribe it, possibly because it is licensed for men, or they are restricted by local prescribing guidelines.

"Some NHS GPs will prescribe it only once a specialist doctor has decided it is the right treatment for the woman," says Dr Hamoda.

"A testosterone patch for women would be a welcome addition in the UK. Having a preparation manufactured specifically for them would be more reassuring."

Its not known how many women are currently taking testosterone therapy in the UK.


Testosterone gel is available on the NHS and privately at a cost of around 80 for a six-month supply. To get it privately you will need to pay for a consultation with a private doctor who may carry out a blood test to check your testosterone levels.


Yes, the three testosterone gels currently available for women in this country are manufactured for use by men. This can make it hard for women to estimate the dose they need (women will need to take a small proportion of a sachet, for example, as advised by their doctor).

"Doses are normally around 5mg a day for women 10 times lower than the typical 50mg a day for men," according to Dr Hamoda.

Testosterone deficiency in men is coined by some as the "male menopause" but is a controversial issue, with some experts saying it is a significant problem, while others question its existence.

Yet Superdrug Online Doctor, for example, has seen a consistent increase in demand for its male testosterone test-and-treat service which was launched in 2019. Over the past 12 months, there has been a 190 per cent increase in orders for this service.

The new patch will do the same job as the gels currently available. However, because it is formulated for women it will take the guess work and worry out of how much gel to apply.

"The patch is also a convenient way to receive testosterone, like oestrogen patches which are commonly used in HRT," says Dr Hamoda.

No, another testosterone patch for women called Intrinsa was developed and made available on the NHS in 2007.

However, this was withdrawn around 10 years ago for commercial reasons. In the US it was never approved due to inadequate data.

A new female testosterone cream, AndroFeme, has been licensed recently in Australia, but is currently not approved in the UK, although it can be imported for private use under a special licence from the medicines regulator, the Medicines and Healthcare products Regulatory Authority (MHRA).

The new testosterone patch for women suffering "low libido and reduced zest for life due to the menopause" is being developed by a company associated with the University of Warwick. David Haddleton, a professor of chemistry who is leading the research, says trials of the new patch will start in the autumn (2023).

He said: "The work were doing isnt just theoretical, but instead aimed at a problem women are facing, which can drastically affect their everyday lives and job.

"This could deliver a product that is much needed and is just not available." However, even if the trials are successful, it is likely to be several more years before the patches are widely available.

"Overall, testosterone treatment is very safe and side-effects in women are uncommon," says Dr Hamoda.

"However, as with all androgen (male sex hormone) treatments there are potential side-effects including acne, excess hair growth and hair thinning but these tend to occur when taking higher doses of testosterone.

"You would have to take a lot over a long period of time to experience these. Taking just above the recommended dose is unlikely to cause any problems."

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Could wearing a testosterone patch reignite women's sex drive ... - The Irish News

Apr 25

Bardstown man facing charges in connection to drug overdose death – WLKY Louisville

A Bardstown man is facing charges in connection to a deadly overdose.William Auberry is charged with manslaughter in connection to the death of Austin Wayne.The 30-year-old was found dead inside a bathroom of a home in Bardstown last week.Court records said that Wayne's girlfriend was able to pull the screen out of a bathroom window, and that's when they found Wayne slumped backward over the toilet. Police then entered the home and found a baggie of what they believed was a mixture of heroin and fentanyl in a nearby bedroom.In addition to that, police found a vial of testosterone and several unopened syringes on top of a dresser.Arrest records said that in an interview with Auberry, he admitted to providing Wayne with heroin.Auberry is being charged with manslaughter, trafficking a controlled substance and drug paraphernalia buying/possessing. A judge set Auberry's bond at $100,000, and he is scheduled to be arraigned in court on Tuesday morning.

A Bardstown man is facing charges in connection to a deadly overdose.

William Auberry is charged with manslaughter in connection to the death of Austin Wayne.

The 30-year-old was found dead inside a bathroom of a home in Bardstown last week.

Court records said that Wayne's girlfriend was able to pull the screen out of a bathroom window, and that's when they found Wayne slumped backward over the toilet. Police then entered the home and found a baggie of what they believed was a mixture of heroin and fentanyl in a nearby bedroom.

In addition to that, police found a vial of testosterone and several unopened syringes on top of a dresser.

Arrest records said that in an interview with Auberry, he admitted to providing Wayne with heroin.

Auberry is being charged with manslaughter, trafficking a controlled substance and drug paraphernalia buying/possessing.

A judge set Auberry's bond at $100,000, and he is scheduled to be arraigned in court on Tuesday morning.

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Bardstown man facing charges in connection to drug overdose death - WLKY Louisville

Apr 25

Experience the Benefits of Regenerative Medicine Treatments at QC Kinetix (Westover Hills) in San Antonio, TX – Yahoo Finance

San Antonio, TX - (NewMediaWire) - April 18, 2023 - Sports injuries can significantly impact athletes and active individuals, making it challenging to perform activities and participate in different sports. At QC Kinetix (Westover Hills), their regenerative medicine therapies have helped many patients recover from various sports injuries, including tendon, ligament & muscle pain, rotator cuff tears, and more. These innovative techniques address the underlying causes of pain, injury and discomfort, providing long-term relief and improved activity levels. By using the body's natural mechanisms to restore function and improve mobility, patients can quickly return to their daily routines with minimal downtime.

At QC Kinetix (Westover Hills), the clinic's regenerative medicine therapies are not only effective for sports injuries but also provide relief from chronic pain conditions such as knee pain, shoulder pain, elbow pain, ankle pain, hip pain, pain due to arthritis, and more. The treatments are minimally invasive, avoiding the risks and complications associated with surgical procedures. This approach has been shown to provide long-term relief from musculoskeletal pain, improving patients' overall well-being and quality of life.

Whether an individual is an athlete or someone experiencing chronic pain, QC Kinetix (Westover Hills) offers a natural and safe alternative to traditional treatments. With its evidence-based regenerative medicine therapies, patients can experience long-term relief from pain and discomfort, allowing them to participate in various activities and sports with ease.

QC Kinetix (Westover Hills) also offers testosterone replacement therapy to help men combat the effects of low testosterone and improve their overall health. The clinic understands the importance of a healthy hormone balance for men's overall well-being. The San Antonio testosterone replacement therapy boosts testosterone levels and achieves a balance with the rest of the body's biochemistry. The treatment is designed for patients experiencing symptoms such as chronic fatigue, loss of libido, muscle weakness, weight gain, poor sleep, anxiety, and more. With a comprehensive exam and laboratory analysis, its team can accurately determine if a patient's testosterone levels are low and devise a personalized treatment plan that meets their unique needs.

QC Kinetix (Westover Hills) follows a comprehensive approach to determine patients' eligibility for regenerative medicine treatments. The clinic recommends that patients schedule a consultation with their medical team, where experienced board-certified physicians will review their medical history and conduct a thorough physical examination to assess their condition. The clinic is committed to providing personalized, concierge-level service to each patient. From the initial consultation to the follow-up appointments, the medical team takes the time to listen to each patient's concerns, evaluate their condition, and develop a personalized treatment plan that fits their specific needs and goals.

This personalized approach to care not only ensures the best possible outcomes but also helps patients feel more comfortable and confident throughout the entire treatment process. By providing individualized attention and care, QC Kinetix (Westover Hills) believes they can help their patients achieve optimal results and improve their overall quality of life.

Moreover, the clinic uses the latest diagnostic equipment and techniques to ensure patients receive the most accurate diagnosis and treatment plan possible. QC Kinetix (Westover Hills) utilizes advanced imaging techniques that allow the physicians to visualize the area of concern in real-time, ensuring precise and accurate placement of regenerative medicine treatments. With a focus on providing the best possible care, the clinic continues to invest in the latest equipment and techniques to improve patient outcomes and ensure optimal results.

QC Kinetix (Westover Hills) offers state-of-the-art facilities and a spa-like environment that helps patients feel at ease. From comfortable waiting areas to private treatment rooms, the clinic is designed to provide patients with a relaxing and stress-free environment. Moreover, the clinic's staff is known for being friendly, welcoming, and attentive to each patient's needs. They understand that the regenerative medicine treatments can be a new experience for many patients, and they take extra care to ensure that patients feel comfortable throughout the process.

QC Kinetix (Westover Hills) is located at 3903 Wiseman Blvd, Suite 303, San Antonio, TX, 78251, US. To schedule a consultation, contact their team at (210) 571-0318. For more information regarding the services offered, visit the clinic's website.

Media Contact:

Company Name: QC Kinetix (Westover Hills)

Contact Person: Casey Sietsema

Phone: (210) 571-0318

Address: 3903 Wiseman Blvd, Suite 303

City: San Antonio

State: TX

Postal Code: 78251

Country: US


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Experience the Benefits of Regenerative Medicine Treatments at QC Kinetix (Westover Hills) in San Antonio, TX - Yahoo Finance

Apr 25

St. Louis gender clinic accusations unsubstantiated, internal investigation finds – NBC News

Washington University in St. Louis said a former employees allegations that its pediatric and adolescent transgender clinic did not appropriately assess minors before providing them with care are unsubstantiated, according to the findings of an internal investigation released Friday.

In February, Missouri Attorney General Andrew Bailey launched an investigation into the Transgender Center at the St. Louis Childrens Hospital after Jamie Reed, who was a case worker at the center from 2018 to November 2022, alleged in a 23-page affidavit that children were being routinely prescribed puberty blockers or hormone therapy without appropriate or accurate mental health assessments. Baileys investigation is ongoing.

Reed also alleged that the centers providers regularly refer minors for gender transition surgery, even though providers have testified at the state Legislature that operations are not an option for anyone under 18.

On the same day the attorney generals office announced its investigation, Reed went public with her allegations in an op-ed published in The Free Press, a news website started by Bari Weiss, a former op-ed writer and editor at The New York Times. Reed, who has a masters degree in clinical research management, concluded her op-ed by calling for a moratorium on the hormonal and surgical treatment of young people with gender dysphoria.

Washington University in St. Louis, the parent institution of the Childrens Hospital, said in a statement that it was alarmed by the allegations and would look into Reeds claims.

After an eight-week internal investigation, the university said in a summary of its findings that her allegations are unsubstantiated but that it would be changing some of its practices.

Washington University physicians and staff at the Center follow appropriate policies and procedures and treat patients according to the currently accepted standard of care, as recommended by the American Academy of Pediatrics and other nationally recognized organizations, the university said in the summary.

Reeds attorney did not immediately return a request for comment.

In her affidavit, Reed alleged patients were routinely provided medication without informed parental consent. She also alleged that the center did not obtain custody agreements from divorced parents to ensure all parties consented to treatment.

Though the university does not mention these allegations in the investigation summary, it said that, going forward, the Transgender Center will require written consent from parents prior to prescribing gender-affirming medications, such as puberty blockers and hormone therapy. Previously, providers obtained verbal parental consent for treatment and documented it in the patients medical record, according to the summary.

The center will also require a family to provide custody agreements before an initial visit at the center if the patient is a minor, the summary said. Previously, providers would ask for custody agreements before medical intervention in cases where decision-making authority was in question.

Regarding Reeds allegations about surgery referrals, the university said the center hasnt provided such referrals for patients under 18 since late 2018, when it adopted a policy prohibiting them.

Upon request, some families were provided with the names of surgeons (including Washington University physicians) who provided such surgeries, and the Centers providers have provided summaries of care for patients desiring surgical interventions, the university said in the investigation summary.

The university said that physicians will no longer perform gender-affirming operations on minors. Washington University declined to say when it adopted this policy.

The university said a total of six operations were performed on minors by university physicians since 2018, and that all six were chest operations for adolescents transitioning to male. The referrals were all from other medical providers outside of the center or were patient-initiated self-referrals, the university said.

It noted that chest masculinization surgery for minors is within the standard of care recommended by the World Professional Association for Transgender Health, or WPATH, a nonprofit association dedicated to transgender medical care. WPATHs standards, which were recently updated last year, recommend minors meet a list of criteria before they can be eligible for surgery.

Two former employees of the center said it follows the standard of care recommended by WPATH.

Jess Jones, who uses they/them pronouns and was an education liaison at the center from 2018 to 2020, shared a variety of documents regarding the centers protocols, including documents that they said were provided to every family at their first visit, an endocrine roadmap that outlined steps patients had to complete to start gender-affirming treatment, and internal documents with hypothetical patient cases that the center used for teaching.

Christine Hyman, whose son has been a patient at the center since 2018, shared emails she received from Reed following her sons appointments. The email includes one of the same documents Jones shared about masculinizing hormones. It details when a patient should freeze their eggs if they are interested in doing so and a chart on the various effects of testosterone and whether they are reversible, partially reversible or irreversible.

Theyre just a wealth of information, Hyman said of the clinics doctors. Theyve been fabulous the whole way through, especially with a parent who walked in, and I was like, Help.

Jones said the center would sometimes gatekeep access to care, which is why Jamies account was so appalling.

She made it sound like we were just handing out hormones left and right to kids, Jones said, when in reality Jones said minors had to meet a number of criteria before they could access care.

The center declined to comment.

Cate Hensley, who uses they and she pronouns and worked at the center from August 2020 to May 2021 as part of getting their masters in social work at Washington University, said they reported directly to Reed. They said Reed frequently interpreted kids experiences as being exaggerated or not being truthful, which was troubling to Hensley, who said that was antithetical to their clinical mental health training.

They said what stood out to them the most in Reeds affidavit and op-ed was how she violated the trust of patients who did not consent to having their private health information publicly shared. They said they could identify some of the cases Reed described in her affidavit, but that Reed misunderstood or misinterpreted them.

For example, Hensley said they remember the medical team discussing a situation Reed describes in her affidavit in which a patient experienced vaginal lacerations after having sex while on testosterone, which can cause thinning of the vaginal tissue, but Hensley didnt want to discuss it in detail because it is private patient information. They said Reed also described a child who said they identify as an attack helicopter, which Hensley said was a joke and is a reference to an internet meme and sci-fi story.

Hensley said the legislative landscape in Missouri, where the Republican-led House passed a bill last week that would ban gender-affirming care for minors, makes Reeds allegations more insidious.

Its more important than ever that the center is able to continue running and provide ethical client-centered care, and what Jamie has done is not grounded in any evidence, is absolutely fueling transphobia and hate here in the state, and will directly harm kids, Hensley said.

Jo Yurcaba is a reporter for NBC Out.

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St. Louis gender clinic accusations unsubstantiated, internal investigation finds - NBC News

Apr 25

One in six couples struggle with infertility – Trinidad & Tobago Express Newspapers

To mark Infertility Awareness Week which runs from April 23-29, Consultant Gynaecologist and Medical Director at Trinidad &Tobago IVF and Fertility Centre, Dr Catherine Minto-Bain is shining the spotlight on the common but frequently misunderstood medical condition. She is also busting the myth that testosterone therapy boosts fertility. The truth, says

Minto-Bain, is that this form of therapy whether in the form of tablets, gel or injections drops fertility. We need to talk about infertility more, said Minto-Bain. Usually the causes of the problem can be found and there are a range of treatments that can work. However, infertility is surrounded by embarrassment, shame and fear, especially in T&T.

Developing countries such as ours have higher rates of infertility than first world countries. Minto-Bain suspects that one in six couples who are trying to get pregnant in T&T may be dealing with infertility. Because many are having unwanted babies and some couples are choosing not to have children, the couples who are actually struggling to get pregnant because of infertility are often overshadowed.

Half of the couples that visit the TTIVF have more than one problem causing infertility, said Minto-Bain. The number one cause behind infertility is the male factor - low sperm counts, poor sperm swimming and poor sperm shapes. Poor sperm quality which stops pregnancies is also very common but is often missed because they dont show up on basic sperm tests.

Erectile dysfunction and couples having difficulties having sexual intercourse for a variety of reasons can also contribute to infertility. Then there are female-related problems such as eggs being lower in quality (which is a frequent problem), and running out of eggs prematurely in life which is common among women of colour. Polyps and scar tissue can also stop pregnancies. Another major factor is age-related fertility problems.

Infertility is diagnosed when you havent had the baby you want after a year of trying. If the woman is 36 or older, then its six months of trying to conceive, without success.

When couples come to the TTIVF, Minto-Bains focus is on determining whats behind the infertility, this involves a thorough examination of the woman and mans overall health and lifestyle.

In men we do a basic semen analysis or sperm test that looks at the numbers of sperm hes producing, their shapes which gives us an idea of whether they can make a baby or not, their swimming and anything else in the semen that could be causing a problem, explained Minto-Bain. We look at the womans egg numbers and her hormones especially the prolactin hormone which can cause difficulties with the eggs actually coming out, we also do a full blood count, a thyroid check to see if there is anything wrong with the thyroid gland that might be causing an increase in the miscarriage risk or having an effect on eggs. A detailed fertility ultrasound is also done.

Many misconceptions

There are many misconceptions about infertility; it is widely believed that its the womans problem because she is the one who carries the baby. However, it is a couples problem and one that requires the intervention of a fertility specialist, rather than a non-specialist doctor, stressed Minto-Bain.

One of the biggest myths is that male infertility particularly low sperm counts can be easily sorted out through a hormone pill, a testosterone injection or a herbal supplement. While these may not be dangerous to a mans health, they do not cure male infertility.

The danger is that these ineffective treatments waste money and time and when the woman eventually comes to a fertility clinic she is a lot older and her chances of having a family has dropped. So the couple will end up having to spend more money on aggressive treatments, lamented Minto-Bain.

While testosterone is made naturally inside the testicle and is part of the production of sperm - it is a contraceptive.

If you put testosterone into your body from an outside source, be it in the form of a tablet, gel or injection, the body will stop producing testosterone and the sperm counts will drop. A lot of men take many months for the sperm production to come back after testosterone therapy. Testosterone doesnt boost fertility, it drops it, she added.

There are many ways to have the family that you want; the TTIVF provides simple treatments including growing ones eggs with fertility medications, intrauterine insemination and donor sperm.

Some couples choose to adopt an embryo and have an IVF treatment-type cycle where an embryo is put inside a womans womb so that she can grow a baby. The TTIVF is also providing hope to persons with cancer who want to freeze their eggs or sperm.

Although IVF treatment offers persons the hope of finally realising their dream of becoming parents, the fact is that it is very expensive. In many countries around the world, including T&T, governments do not fund fertility treatment.

Personally, I view infertility as a medical condition and as something which I believe healthcare should cover whether its insurance or government paid healthcare. I would love it if an insurance company would cover at least infertility testing, if not fertility treatments. And I would love it if the government could provide a free fertility service through the public hospitals, I would be willing to be involved in setting it up and training medical professionals. T&T has a big problem with infertility, therefore treatment should be accessible to anyone who needs it, said Minto-Bain.

The TTIVF has seen an increase in persons coming to Trinidad for IVF treatment because it is less expensive than in the US or the UK. Since its establishment, 2,500 babies have been born to grateful parents thanks to the clinics intervention - that figure could be much higher, said Minto-Bain.

Fertility is a fast-paced specialty and the consultant gynaecologist couldnt be more excited about the future. Its exciting to look at new changes that are coming and to know that we have all the expertise to run a well-structured clinic that hits all the top-quality markers that you would get in an overseas clinic,said Minto-Bain. When new treatments come in were ready to provide them in T&T, we are on the forefront of whats going on.

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One in six couples struggle with infertility - Trinidad & Tobago Express Newspapers

Apr 17

Testosterone therapy in trans men results in shifts in the neural processing of emotion, study finds – PsyPost

Most people would agree that men and women experience emotions differently, due to a combination of brain structure, hormones, and socialization. This leads to the question, when a transgender person undergoes gender-affirming care, does their emotional processing change? A study published in Psychoneuroendocrinology suggests that hormone therapy can change emotional perception in transgender individuals.

Many people who identify as transgender seek out gender-affirming treatments such as hormone therapy and surgery to help their body feel like it matches their gender identity. Hormone therapy can change more than just a persons body, also having significant effects on the brain. Sex hormones have been thought to be associated with gender differences in body perception, self-referential processing, language processing, and basic emotion perception.

Despite this, the research on how the brain changes during hormone therapy has been lacking. This study seeks to bridge that gap in research and explore how hormone therapy can affect emotional perception.

Meltem Kiyar and colleagues utilized 26 transgender men, 29 cisgender men, and 30 cisgender women to serve as their sample. Data collection occurred in Belgium. Data was collected at baseline and 6 to 10 months later. Participants were age matched, but their educational levels varied. A clinician administered a neuropsychiatric interview before session 1.

Participants completed questionnaires on anxiety, stress, depression, and sexual orientation. Trans men began receiving long lasting testosterone injections every 12 weeks after the first session and hormone levels were monitored.

All participants underwent an experimental emotional processing task while undergoing an MRI. The task included faces that represented neutral, happy, angry, and surprised expressions that were grey scaled, had the hair removed, or made to look more agender.

Results showed that cisgender men and women differed in that cisgender men showed lower neural activity when they had higher testosterone, and cisgender women showed higher neural activity when they had higher levels of testosterone.

The researchers found that the neural processing of emotions from session 1 to session 2 was significantly different for trans men, while it remained stable for cis men and women. At timepoint 1, trans men showed neural activity similar to cisgender women, while after hormone therapy, they showed neural activity similar to cisgender men.

A clear effect of testosterone administration on affective neurocircuitry was present in [trans men] after only 610 months of [gender-affirming hormone therapy]. Specifically, in the bilateral amygdala and the [anterior cingulate cortex], neural patterns of processing emotions shifted from a sex-assigned at birth to a gender identity pattern in [trans men] after initiating [gender-affirming hormone therapy], the researchers said.

This was consistent for positive, negative, and ambiguous emotional stimuli.

This study provides further evidence on how testosterone affects affective neurocircuitry when processing positive, negative and ambiguous emotions and may contribute to our understanding of emotion perception in the brain, the researchers added.

This study took interesting and important steps into better understanding how hormone therapy can affect emotional processing. Despite this, there are limitations to note. One such limitation is that this study did not include trans women, so we cannot extrapolate that estrogen would show similar effects. Additionally, timepoint 2 ranged from 6 to 10 months because of COVID-19, which is less consistent. Lastly, other important factors, such as menstruation, were not taken into consideration.

The study, Gender-affirming hormonal treatment changes neural processing of emotions in trans men: An fMRI study, was authored by

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Testosterone therapy in trans men results in shifts in the neural processing of emotion, study finds - PsyPost

Apr 17

7 Testosterone-Killing Foods You Should Always Avoid – Eat This, Not That

Testosterone is a vital sex hormone for both men and women. It plays a crucial role in maintaining bone density, muscle mass, sex drive, and overall health, according to the National Institutes of Health (NIH). However, our bodies naturally produce less testosterone as we age, leading to various health issues, including obesity, insulin resistance, and diabetes, WebMD explains. Fortunately, several ways to maintain healthy testosterone levels include regular exercise and a balanced diet. You may be surprised to learn that some foods can negatively impact testosterone production, leading to lower levels of this essential hormone. That's why we chatted with health and nutrition experts who discuss seven testosterone-killing foods you should avoid if you want to maintain optimal testosterone levels.

From processed foods to sugar-laden snacks, certain foods can wreak havoc on our hormones, including testosterone. By understanding which foods to stay clear of, you can make smarter dietary choices and help ensure your body functions at its best. So, whether you want to improve your athletic performance or simply maintain your health as you age, read on to discover seven testosterone-killing foods you should always avoid.

"Drinking more than one or two drinks per day can lower testosterone levels in men by disrupting the signals from the brain to the testes for testosterone production and decreasing the ability of the testes to produce the hormone in other ways," Kelsey Kunik, RDN, a registered dietitian nutritionist and nutrition advisor for Zenmaster Wellness, tells ETNT."Alcohol also disrupts sleep, which studies have found can cause a 10 to 15% drop in testosterone production."

Alcohol affects your liver's ability to break down estrogen, which leads to a decrease in testosterone production. So if you want to maintain healthy testosterone levels, limit your alcohol consumption.

RELATED: 5 Exercises for Men To Increase Testosterone

Spearmint is a popular herb often used in teas and other beverages. However, it has been found to have anti-androgenic effects, which means it can reduce testosterone levels. This is particularly true when consumed in large amounts, so it's best to avoid it to maintain healthy testosterone levels.

"While spearmint's testosterone-lowering effects could benefit women with polycystic ovary syndrome (PCOS), research needs to be done on how spearmint can affect testosterone levels in men," says Kunik.

Sugar-sweetened beverages such as sodas and energy drinks are loaded with added sugars and can lead to weight gain and obesity, research shows. As a result, sugary drinks can have a negative effect on testosterone levels. For example, a study published in Reproductive Biology and Endocrinology found that high consumption of sugar-sweetened beverages was significantly associated with low testosterone in U.S. adult males aged 20 to 39.6254a4d1642c605c54bf1cab17d50f1e

"Sugary drinks and other sugary foods raise blood sugar, which creates a hormonal cascade effect that lowers testosterone production," explains Kunik. "High blood sugar prevents the pituitary gland from producing enough luteinizing hormone, which helps stimulate testosterone production in the testes."

RELATED: 50 Best Foods for Men

Refined carbs from bread and pastries can have a negative effect on testosterone levels because of their high sugar content, which contributes to weight gain and obesity.

"Several studies suggest that testosterone levels may drop from eating out frequently," says Denise Coventry, RD, a registered dietitian specializing in gastrointestinal health. "Your diet quality can change with large portions of bread, pastries, and desserts without balancing the need for dark green vegetables and wholesome meals made at home."

Processed meats, such as sausages and bacon, are often high in saturated fat and have been linked to various health problems. They can also have a negative effect on testosterone levels. According to a study published in Human Reproduction, men who consumed high amounts of processed meat had a 15% lower volume of testosterone and a 37% decrease in sperm count.

"Studies have found low testosterone levels and low-quality sperm in men who consumed more processed meats and their diet was lower in beans, legumes, vegetables, and dairy," states Nicole Ibarra, RD, a registered dietitian and nutrition coach.

RELATED: 21 Foods To Increase Sex Drive & Libido, According to Science

"Regularly eating an abundance of high-calorie, high-fat foods like fast food combo orders of burgers and fries might not be helping your sex hormones, including testosterone," cautions Caroline Thomason, RD, CDCES, a Virginia-based registered dietitian. "Forming healthy habits around eating less fast food is a great place to start [for optimal testosterone levels.]."

Research shows that fast food is often loaded with unhealthy fats, added sugars, and excess caloriesa recipe for unhealthy weight gain that can negatively impact testosterone levels.

Flaxseed rounds out our list of testosterone-killing foods. Research suggests that consuming large amounts of flaxseeds can lead to a decrease in testosterone levels in men. For example, a study published in Urology found that men who had prostate cancer and were supplemented with flaxseed experienced significantly reduced testosterone levels.

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7 Testosterone-Killing Foods You Should Always Avoid - Eat This, Not That

Apr 17

Optimize Testosterone With Proper Diet and Exercise – Giddy

Out-of-whack hormones can affect anyone. Physical activity and nutrition are keys to balance.

In this era of ubiquitous ads for standalone men's health clinics and testosterone-boosting products, some people seem to think of testosterone as just a little something extra: a boost that guys might want to add to their daily supplement cocktail.

There's so much more to testosterone. It's definitely not a daily B-complex vitamin you thoughtlessly gulp down with your morning coffee. Poorly calibrated testosterone levels can have effects both subtle and not so subtle on all sorts of bodily functions.

It's a two-way street: The lifestyle choices we make have a tremendous impact on our hormones. The ways we choose to eat, exercise, sleep and celebrate can all exert a great deal of control over our natural testosterone production.

Find out how diet and nutrition affect testosterone production, as well as how exercise can help your body optimize testosterone levels. Learn how testosterone isn't just for guys and estrogen isn't just for women.

It's true that testosterone gives males many of their typical characteristics. The tsunami of testosterone that washes through boys during adolescence results in adults with deeper voices, body and facial hair, larger muscles and a healthy, functioning reproductive system.

Testosterone is also at play for assigned female at birth (AFAB) people who transition to male later in life. Transgender men are often given testosterone injections and other hormone therapies to help them feel less gender dysphoric in their bodies and give them more typically male characteristics.

Know that testosterone is a naturally produced hormone that all human bodies make throughout their lives. As such, it's very much affected by the type of fuel you feed the machine: garbage in, garbage out, as they say.

"Eating behaviors that often result in weight gain, like eating processed foods and large-portion sizes, may also lead to the development of chronic diseases like heart disease and insulin resistance," said Amy Pearlman, M.D., a men's health specialist and co-founder of Prime Institute in Fort Lauderdale, Florida. "And chronic illness is also associated with low testosterone levels."

Conversely, it's fairly well known that a diet rich in whole foods, low in processed foods and sugars, and high in fiber has an impact on so many aspects of our health. It's no surprise that one of those areas is testosterone production.

However, it's buyer beware if you put too much stock in articles that make claims such as, "These five superfoods will instantly boost your testosterone!"

The science simply isn't there yet to strongly assert that specific foods directly affect testosterone levels, according to Pearlman.

"The impact of nutrition on testosterone hasn't been teased out to provide concrete recommendations," she said. "The impact of specific macro/micronutrient diets and types of calories on male sex hormones have been studied. But some studies show changes in male sex hormones with various nutritional intake, whereas others show no association. The impact of calorie restriction is also unclear."

There is, however, one major exception, and it means bad news for all you soda lovers out there.

"Data suggest that drinking sugar-sweetened beverages with high-glycemic loads results in an immediate decrease in total testosterone and free testosterone," Pearlman said.

A study of a group of men with various degrees of glucose tolerance, both healthy and unhealthy, showed a 25 percent drop in testosterone levels that lasted for at least two hours after they ingested a 75-gram glucose tolerance test about two Coke's worth of sugar. Around 15 percent of the subjects saw their post-glucose testosterone levels drop to the point of being hypogonadal, or meeting the clinical definition of low testosterone.

Apart from diet especially giving up soda the other good news about our ability to control our own testosterone levels has to do with exercise and the scope of its benefits. Consider the major ways we can naturally boost testosterone production:

Of these, exercise might be the most exciting, simply because it can enhance so many of the other strategies. For instance, regular exercise helps with weight control and regulating sleep. You could even say it discourages drinking too much, because who wants to work out with a hangover?

"We know that excess body weight either overweight or obese is very common and can also result in low testosterone levels," Pearlman said.

The great news is that the research suggests for men with obesity, adding a regular exercise program to their dietary weight-loss regimen consistently shows improvement in testosterone production.

One yearlong study from 2008 recruited a group of men who hadn't previously engaged in regular exercise. Researchers found their levels of the androgen dihydrotestosterone (DHT) a crucial metabolite of testosterone that's three to six times stronger than testosterone itself jumped by nearly 15 percent.

Another study, this one from 2012, suggested that men who exercised regularly not only had healthier hormone numbers than sedentary men, but also had healthier semen.

In other good news for men who are overweight or obese, a 2016 study showed that exercise did more to increase testosterone levels than losing weight.

Finally, it's high time to debunk the mythos around testosterone being "the dude's hormone" and estrogen being "the hormone for the ladies."

As noted above, all humans, including cisgender and transgender people all along the spectrum, naturally produce some amount of testosterone and estrogen. It just happens that males organically produce more testosterone, and females produce more estrogen.

However, for guys who are considering testosterone replacement therapy (TRT), understanding the delicate balance of these paired hormones and how they work is crucial.

Too much testosterone can kick your natural estrogen production into high gear. That's part of the reason it's inadvisable to attempt do-it-yourself TRT or to go to a single-solution clinic that doesn't do the proper prescreening and/or follow-up bloodwork once it has started you on TRT.

That can cause significant problems.

"Testosterone gets converted to estrogen via an enzyme called aromatase, and it's present in a variety of cells in the body and it's also present in fat cells," Pearlman said. "Some people will convert a lot of their testosterone to estrogen. And when estrogen is too high, it can cause breast tenderness, breast swelling and retaining fluid, but we can put people on medication to block that conversion."

Balance is the key. Don't be fooled into thinking TRT is something you can take up casually.

It's true the human body is a remarkable machine, and we know a lot about how to gently and effectively nudge its inner workings in one direction or another, but clumsily, thoughtlessly messing with your hormones can cause serious trouble.

Before you decide low-T is the reason for your symptoms, consult your physician. Don't have a doctor you see regularly? You should. Fortunately, telehealth makes it easy to connect with a professional who can answer your questions and evaluate your situation. Many physicians offer same-day video visits. Giddy Telehealth is an easy-to-use online portal that provides access to hundreds of healthcare professionals whose expertise covers the full scope of medical care.

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Optimize Testosterone With Proper Diet and Exercise - Giddy

Apr 17

You Can Treat Menopause Symptoms with Testosterone Pellets – Orlando Health

Going through menopause can be tough as you suffer through hot flashes and other unpleasant symptoms. Testosterone pellets are one of the best ways to curb menopause symptoms, yet few women know about or use them.

As womens bodies taper out of their child-bearing years, they experience menopause. In some cases, the transition involves any or all of nine unpleasant symptoms.

While many women simply ride out the symptoms over a few months or even several years, others try a variety of tactics to decrease discomfort. Those range from herbal supplements to estrogen replacement therapy, which might involve a pill, ring or cream.

Testosterone pellets are an alternative that have been found to work remarkably well. They are tiny time-release pellets containing low-dose testosterone.

These pellets are a good bet for nearly all menopausal women, even those with medical challenges. To determine the best dose for you, your doctor will test your blood beforehand to assess your natural hormone levels.

Then the process works like this:

The U.S. Food and Drug Administration (FDA) has not yet approved testosterone therapy, but it is not a new treatment for curbing menopause symptoms. In fact, testosterone therapy has been an option for decades. The treatment has been licensed to use in England and Australia for more than 60 years.

Researchers have compiled growing evidence to prove that using it is safe, even in the long term, according to a recent study on the complications of subcutaneous hormone-pellet therapy.

Still, testosterone pellets remain under the radar in the United States. In terms of popularity, the treatment is ranked at 12 percent, while estrogen, at 43 percent, ranks only below diet and exercise as the most used. Thats according to a new online national survey commissioned by Orlando Health and conducted by The Harris Poll.

If youre experiencing fatigue, brain fog or other menopausal symptoms, talk to your doctor about actions you can take to feel better.

Be sure to include testosterone pellets in the discussion, even if youre the one to bring it up. Testosterone therapy helps many women feel better within days of treatment. Once a pellet is inserted, youll likely have more energy to enjoy life. It might also boost your sex drive and decrease vaginal dryness, improving your romantic relationship with your partner.

Other than discomfort due to the incision used for the implant, testosterone pellets have few side effects, which can be discussed with your physician.

Testosterone pellets are a simple solution and are an option for virtually every patient regardless of their medical condition or history.

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You Can Treat Menopause Symptoms with Testosterone Pellets - Orlando Health

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