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Adele has a huge fan base, has sold more than 120 million records, has won 15 Grammy Awards, and has a new album coming out. But none of these achievements has garnered the singer quite as much attention as her recent weight loss and she wants people to know shes not okay with that.

In May 2020, the "Rolling in the Deep" singer posted a photo to her Instagram account that revealed a much slimmer physique, and unleashed an onslaught of headlines celebrating her visible weight loss something she had never spoken about publicly. It wasnt until her November 2021 interview with British Vogue that Adele opened up about her weight loss, and the public's reaction to it, for the first time.

It turns out that Adeles silence on the subject of her weight was entirely intentional.

My bodys been objectified my entire career, she said in the British Vogue article. The most brutal conversations were being had by other women about my body. I was very f***ing disappointed with that.

RELATED: Why Fitness Is Way More Than Hitting the Gym

Now that she is finally breaking her silence about her weight loss journey, Adele is taking a nontraditional approach by challenging the public reaction to her changing body rather than celebrating her newfound slimness. I did it for myself and not anyone else, Adele told British Vogue. So why would I ever share it? I dont find it fascinating. Its my body.

Frankly, thats a healthy choice for her, and pretty refreshing for the rest of us, too, says Paula Atkinson, LICSW, a psychotherapist who specializes in eating disorders. So often, Atkinson says, celebrity weight loss stories are meticulously documented, and this can be extremely triggering and send the unrealistic message that, "If I can do it, you can, too!"

Here are some real lessons Atkinson says we can glean from Adeles experience ones that have nothing to do with counting calories or fitting into a smaller size.

Adele told British Vogue that she didnt start exercising as a way to lose weight, but rather as a way to manage her mental health. It was because of my anxiety, the singer said. Working out, I would just feel better.

There is evidence that exercise can help decrease anxiety, Atkinson says. A systematic review and meta-analysis published in 2018 in BMC Health Services Research analyzed data from 15 previous studies and found that both high-intensity and low-intensity exercise reduced anxiety among participants (although high-intensity exercise had a greater effect).

Its also important to note that you dont need to lose weight to reap these benefits. In fact, a review published in September 2021 in iScience found that increased physical activity and fitness significantly improved the health and longevity of adults classified as obese, even when they didn't lose weight (which many people do not). On the other hand, weight loss alone isn't consistently associated with these benefits.

RELATED: 8 Ways Strength Training Boosts Your Health and Fitness

Although the rest of the world is talking about Adeles weight loss, she herself is focused on other changes. It was never about losing weight, it was always about becoming strong and giving myself as much time every day without my phone, she told British Vogue. She explained later in the interview that she didnt follow a diet, and that the weight loss happened over the course of two years through exercise.

I appreciate that Adele wanted to move her body more thats so rad, Atkinson says. In addition to helping with anxiety, carving out time to exercise can be a great way to feel connected to your body without distraction. Exercising to feel good can help bolster this sense of connection with your body, whereas exercising for the sole purpose of losing weight might undermine it. Since so much of the messaging about fitness focuses on weight loss, Atkinson says that it can be hard to separate the two. But finding other motivations for moving your body to gain strength and flexibility, to de-stress, or to keep up with your kids, for example is hugely beneficial.

Atkinson warns that praising someones weight loss, even if you mean well, can be harmful. To say that weight loss is positively reinforced is the understatement of the century, she says. Our culture is obsessed with the idea that people in small bodies are superior to people in large bodies. Celebrating Adeles weight, rather than any other aspect of her fitness journey, such as her increased strength or stamina or mental health gains, sends the message that the only attribute that matters is how much a person weighs.

The truth is that most people who lose weight will gain it back. Past research has found that although most people who diet slim down in the short-term, the average amount of weight lost after two years was just two pounds. A review published in the BMJ in February 2020looked at data from 121 trials, with a total of 21,942 participants, and found that although most dieters lost weight in the first six months, that weight loss, and any health benefits that accompanied it, had disappeared by the one-year mark.

When someone regains weight, which is inevitable for most people, theyll remember all the praise they got when they were thinner. And this, Atkinson says, will just make them feel worse about their larger body.

RELATED: Fitness Pros Who Have a Balanced Approach to Wellness

Celebrities, it turns out, arenot just like us. In her interview with British Vogue, Adele readily admits that she had a lot of help in her fitness journey. 'I was basically unemployed when I was doing it,' she told the magazine. "'And I do it with trainers.' She very much gets that its a rich persons game. Its not doable for a lot of people, she says, a bit embarrassed, the article states.

Because of her wealth, Adele was able to spend much of her time and energy on improving her health. Most people arent able to hire a team of people to help them that way, nor are they able to carve huge chunks of time out of their day to devote to exercise. Most people who are able to keep weight off, its because their lives are devoted to that. They typically have to exercise for at least an hour a day, every day, and keep [eating very few calories], Atkinson says. Their number-one priority has to be keeping their body small.

People are shocked because I didnt share my journey. Theyre used to people documenting everything on Instagram, and most people in my position would get a big deal with a diet brand, Adele told British Vogue, adding that people have been talking about her body since the start of her career, long before she lost weight.

Many people are, understandably, upset that Adele has lost this weight. Its just like when Lizzo was on her juice cleanse and people got upset, Atkinson says. It feels like a betrayal, because we have so few celebrities who are not participating in the body hierarchy that we have.

Ultimately, Adele (or Lizzo, or any other celebrity) doesnt owe her body to us. Fundamentally I believe in body autonomy, Atkinson says. "If Adele wants to make lifestyle changes to improve her health, thats great. And if she wants to make her body smaller, thats also just fine. She doesnt need to explain her motivations to anyone."

Atkinson hopes that celebrities in larger bodies who lose weight will use their platform to speak out against the oppression and the marginalization that they experienced before weight loss. But whether or not they want to do that is completely up to them, she says.

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Adele's 100-Plus-Pound Weight Loss: What a Body Positivity Expert Wants You to Know - Everyday Health

If you've tried to lose weight through fasting, cutting carbs, or going hard on cardio it may be time to try something way simpler. A U.K. source is sharing a slick fitness tip from one ofMeghan Markle's trainers, who's come forward with major weight loss wisdom: If you're trying to look slimmer, there's one best-kept secret among some pros that's reportedly shown to deliver major physiological results.

This week, Hello! has reported that back in 2018, Meghan Markle's former trainer, Craig McNamee, revealed that when Meghan was acting on TV, he and the royal took"a full-body approach" to her workouts. McNamee added that "since Meghan was on screen, we really focused on posture," which included lots of core work, as well as exercises focused on the body's posterior sidelike the back, glutes, and hamstrings.

RELATED:15 Underrated Weight Loss Tips That Actually Work

Eleanor Burt, a sports massage therapist with certification in postural alignment, told Hello! that focusing on posture can indeed be a weight loss game-changer. "[G]ood posture helps with weight loss is because it aids the efficiency of practically all of the systems within the body," Burt explained. "The body works as a unit, so your musculoskeletal system's function (or lack thereof) will impact how well you can think, breathe, shift lymph, digest food and expel waste."

She went on to explain that "If you are stuck in a heavily flexed posture (a.k.a. a slumped, sitting position) without the muscular function to pull yourself out of it when you stand up, you will find that excess pressure on the internal organs will impact digestion, breathing patterns, and your general vitality."

Other celebs have been speaking out to say appearance isn't just about weight loss, but overall wellness. ReadAdele Finally Reveals Her 4 Weight Loss Secrets for Shedding 100 Pounds.

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This Is The #1 Underrated Tip for Weight Loss, According to Meghan Markle's Trainer | Eat This Not That - Eat This, Not That

Eating breakfast is important because it helps keep your metabolism going for hours after eating, so if youre not eating breakfast, then your body will start storing fat instead of burning it off.

Many different breakfast ideas can help you lose weight. Some of them are easy to make and others take a little more time, but they all have the same result.

The nutritious breakfast ideas listed below will help you get started on your journey to losing weight.

Smoothies are considered to be one of the best breakfast ideas for weight loss because they are a great way to get essential nutrients from fruit and vegetables.

However, there is also another reason why smoothies should be one of the first things you think about when it comes to healthy breakfasts.

Fruits that have been blended into a drink or put in a blender with other ingredients do not require as much chewing as solid fruits do, so the natural process of digestion begins in your mouth.

The saliva that is produced when you start to chew food works with enzymes in your stomach to break down foods and make them easier for the intestines to absorb nutrients from.

There are several types of smoothies, even keto-friendly ones such as a blueberry smoothie bowl. This filling keto smoothie will help you have the perfect breakfast because it is full of healthy fats and fiber, but low in carbohydrates.

All you need to do is add all of your ingredients into a blender and process until they reach a smooth consistency. Then, pour them in a bowl or cup, put any extra toppings such as coconut flakes, berries, or chia seeds and enjoy.

If you are looking for a simple breakfast idea that takes less than five minutes to prepare then look no further. Avocados have become popular in recent years because they are full of healthy fats which can help you lose weight faster.

They also contain fiber which will keep you full for longer, and potassium which can lower blood pressure.

Eating a slice of avocado toast in the morning will not only give you all the health benefits that this fruit has to offer but will also help speed up your metabolism because they contain B vitamins.

If you want an extra kick then add some cayenne pepper or black pepper for a bit more spice that can also help with weight loss.

One of the most nutritious breakfast ideas is eggs and vegetables, especially when you go for spinach because it contains choline, which can boost your metabolism and burn fat faster. The best part about this recipe is how easy it is to make.

You simply need to fry some onions in a pan, add spinach, fry it for a few more minutes and then scramble in your eggs.

You can choose to have one or two whole eggs with the yolk because both are good sources of protein that will keep you full until lunchtime.

Baked sweet potatoes are another great breakfast idea to help lose weight because they are full of healthy carbs that will keep you energized for hours.

They are also fat-free and contain potassium which helps lower blood pressure, not to mention theyre easy to prepare by simply baking them in the oven until soft.

Most people skip breakfast because they do not have enough time in the morning to prepare a healthy meal, but oatmeal is one of the easiest things you can make.

You simply need to add water or milk into oats and heat them for three minutes on the stovetop or microwave them until soft.

Then, top with berries and cinnamon which are both excellent additions that will speed up your metabolism and lower blood pressure.

If you want a simple breakfast idea but do not like any of the foods mentioned above, then rice cakes with peanut butter are an excellent choice.

They are full of healthy carbs and protein which can help you lose weight faster because they make you feel fuller for longer.

Just be careful not to go overboard on portion sizes as it could lead to unwanted calories that will prevent your body from losing fat.

The goal of a healthy breakfast is to give you the energy and nutrients needed for your day while fostering your weight loss goals. For some people, that means an oatmeal dish with fruit.

Others might need a protein shake after their workout in the morning or a banana and peanut butter toast later on in the day when theyre feeling hungry again.

No matter what type of breakfast you prefer, theres something for everyone who wants to shed off some pounds.

When trying to lose weight, it is important that you watch what you eat, but if you want a healthy breakfast then the options above are simply too good to pass up on.

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How Bike Riding Compares to Other Popular Outdoor Activities

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Simple and Nutritious Breakfast Ideas That Will Help You Lose Weight Bike Hacks - Bicycle Times Magazine

October 15, 2021

There are quite a few consequences of obesity, including conditions such as high blood pressure, diabetes, high cholesterol and heart disease. But did you know that being obese could also shorten your life expectancy?

According to a 2014 study by the Intramural Research Programa subsidiary of the National Institutes of Healthextreme obesity may shorten life expectancy by up to 14 years.

The effects of obesity on life expectancy have been very well studied, says Hans Schmidt, M.D., bariatric surgeon at Hackensack University Medical Center. Theres no question that it can shorten your lifespan, and by large numbers. If you can get the weight off before theres major damage done to your organs, that will tremendously prolong your life.

Worldwide, obesity has nearly tripled since 1975, and at least2.8 million people die each year due to being overweight or obese, according to the World Health Organization (WHO). WHO also found that39 million children under the age of 5 were overweight or obese in 2020.

Globally, 44 percent of diabetes, 23 percent of ischemic heart disease and as much as 41 percent of certain cancers can be attributed to being overweight or obese, according to the WHO.

Whats devastating about numbers like this is that obesity is treatable, Dr. Schmidt says. It doesnt have to be this way.

Losing weight, even just 5 to 10 percent of excess weight, can add years to your life. Not only will you live longer, but also youll feel better and deal with fewer health complications.

Though its entirely possible to lose weight on your own, losing 100 pounds or more can be extremely difficult, says Dr. Schmidt.

Losing that much weight doesnt just require a few changes to your diet and routine, he says. It requires you to overhaul your entire life and way of doing things. Its not easy to do it without help.

Its proven that help, in the form of bariatric surgery, can extend your lifespan.

A study, published in the Lancet in May 2021, found that bariatric surgery was associated with increases in life expectancy among severely obese patients. If metabolic-bariatric surgery rates were increased worldwide to 3.5 percent among patients with diabetes and 2 percent among those without diabetes, more than 19 million life-years could be gained, the study states.

Whether you lose weight with the help of surgery or on your own, its never too late to start the weight loss journey.

A lot of people wait until theyre over 60 years old to lose weight, and by then, youve already done so much damage to your body and bones, Dr. Schmidt says. If you wait until your body is damaged, its hard to put it back together again. Start now.

The material provided through HealthU is intended to be used as general information only and should not replace the advice of your physician. Always consult your physician for individual care.

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How Losing Weight Can Increase Your Life Expectancy - Articles and Videos, Featured, Health Topics, Weight Loss - Hackensack Meridian Health

It is important to understand why and how breast cancer and obesity are related. Read on to know it all.

Written by Editorial Team | Updated : October 15, 2021 8:29 AM IST

Managing weight is indeed becoming a challenge for most people in the modern world. Hectic lifestyles are increasingly forcing people to eat out or choose junk food. A sedentary lifestyle has also become the norm for many people. All this leads to weight gain and hence, it is no wonder that obesity is rampant in the world today. This is dangerous because being overweight puts us at a high risk for a variety of diseases including cancer. There is a lot of evidence now that proves that being overweight or obese after menopause increases the risk of breast cancer .

Post menopausal obese women have a 20-40 per cent increase in the risk of developing the disease. This is, however, not true for younger women. Numerous studies have found a link between a higher BMI (body mass index ) and breast cancer incidence. In fact , obesity and weight gain also increase the risk of death from the disease by affecting breast cancer growth and metastasis or spread. So, it is important to understand why and how breast cancer and obesity are related.

Obesity can trigger some changes in your body that can increase your risk of breast cancer.

This association between obesity and breast cancer is not simple. All studies point to the fact that the risk is more in women who have put on more weight in adulthood and not those who have been overweight since childhood. Also the risk is more in those who have extra fat in the waist area and not in the thighs or hips.

Also, another very important observation is that being overweight increases the incidence of breast cancer recurrence as well in those who have been previously treated for the disease.

The American Cancer Society says that exercise is a "breast healthy habit'. Around 150 minutes of brisk walking each week lowers one's risk of getting breast cancer. Ramping up your exercise routine is of utmost importance. Also eating healthy and eating mindfully helps in controlling weight and reducing the risk in turn. Obesity is an important but completely preventable cause of not only breast cancer, but a variety of other diseases.

So, this breast cancer awareness month, let each one of us take the campaign of reducing the disease in our own hands . Exercise regularly and eat right to maintain a perfect BMI . Stay fit, stay breast cancer free.

(This article is authored by Dr Neha Khandelwal, Senior Gynaecologist, Madhukar Rainbow Hospital.)

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Obesity May Increase Risk Off Breast Cancer By Almost 40%: Lose Weight Before It Is Too Late - TheHealthSite

As soon as the weather gets cooler, my friends and I are pretty much always game for sharing a big pot of soup. When we gather to meet during the week, we take turns making different pots of soup that we can share. Turkey chili, minestrone, creamy pumpkin, chicken tortillathe list goes on. And although we love to drown our soup with all kinds of toppings and dip fresh-baked slices of sourdough bread into our bowls, soup is still a relatively healthy meal to enjoy during the season. In fact, there are numerous soup recipes out there that can even help with your weight loss goalsif that's something you're looking for.

From slow cooker soups to quick chilis and copycat restaurant favorites, here are some of the best soup recipes to make this fall that can even help you with weight loss. Then, be sure to check out our list of the 100 Easiest Recipes to Make for even more healthy meal inspiration.

Nothing beats a classic chicken noodle, especially when the slow cooker makes this popular recipe ten times easier to make.

Get our recipe for Crock-Pot Chicken Noodle Soup.

If you're a fan of Panera's black bean soup, we promise you are going to loves this flavorful version made with tomatos, and cuban spices.

Get our recipe for Cuban Tomato and Black Bean Soup.

Use up leftover pork with this easy slow cooker green chile soup, filled with cannellini beans and pork tenderloin.

Get our recipe for Green Chile Pork Soup.

It's your favorite bowl of noodle soup with a flavorful twist, made with lean beef and Japanese udon noodles.

Get our recipe for Hearty Asian Beef Noodle Soup.

French onion soup isn't as unhealthy as you think, especially when you make our delicious version!

Get our recipe for French Onion Soup.

Between the rosemary and the butternut squash, this soup is the perfect fall-time meal to enjoy with friends. Or even the perfect appetizer for your Thanksgiving festivities!

Get our recipe for Rosemary Butternut Squash Soup.

Keep your chili lean by using ground turkey and lots of hearty white and pinto beans.

Get our recipe for Turkey Chili.

A fun twist on the classic French Onion soup!

Get our recipe for Roasted Shallot Soup with Gorgonzola Croutons.

Use up the leftover vegetables in your fridge and throw together this minestrone soup recipe! Top it with herby pesto and parmesan cheese for a refined finish on an easy-to-make soup.

Get our recipe for Minestrone Soup.

Enjoy your favorite fall vegetable with this pumpkin soup, with an extra boost of fiber from the cauliflower and other hearty vegetables!

Get our recipe Pumpkin and Cauliflower Soup.

This classic soup is full of fatty meatballs and soupy vegetables that makes for a perfect filling weight loss meal.

Get our recipe for Italian Meatball Soup.

Enjoy this classic favorite from Panera, but a much healthier version that can help with losing weight!

Get our recipe for Broccoli-Cheddar Soup.

Potatoes are full of fiber, which helps with weight loss, so enjoying a hearty baked potato soup is a great choice for a lunch if you're trying to lose weight.

Get our recipe for Baked Potato Soup.

This hearty soup seems more like a pasta dish, but still sits in a fatty broth that almost feels like it's the last thing you should be eating for weight loss, but we promise, it's still a healthy option!

Get our recipe for Italian Sausage Soup.

This recipe uses a smoked ham hock for a filling protein that will keep you satisfied for the rest of the day.

Get our recipe for Split Pea Soup.

A spicy tortilla soup on a cold, fall day? Count us in!

Get our recipe for Tortilla Soup.

This creamy mushroom soup is Whole30 compliant and dairy free!

Get our recipe for Creamy Mushroom Soup.

Looking to cut down on your carb intake? This recipe swaps the starchy noodles with zucchini "zoodles" without compromising on any of that chicken soup flavor you love.

Get our recipe for Instant Pot Chicken Zoodle Soup.

Obsessed with Olive Garden's Pasta Fagioli soup? This copycat recipe breaks down each element of the classic favorite and makes it easy to throw together at home.

Get our recipe for Copycat Pasta Fagioli Soup: Olive Garden's Recipe.

Use up that leftover bunch of kale in the fridge and make this potato and kale soup! It's the perfect filling soup recipe for weight loss.

Get our recipe for Potato and Kale Soup.

Instead of that usual tomato-based chili, this white chicken chili is creamy spicy and filled with good-for-you ingredients.

Get our recipe for Instant Pot White Chicken Chili.

Between the spicy sausage and the creamy broth, this soup is a surefire winner if you're making soup for a crowd.

Get our recipe for Instant Pot Zuppa Toscana.

This classic dish is made even simpler with this easy-to-make Instant Pot recipe!

Get our recipe for Instant Pot Chicken and Rice Soup.

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23 Cozy Soup Recipes That Are Perfect For Weight Loss This Fall | Eat This Not That - Eat This, Not That

This Morning hosts Alison Hammond and Dermot OLeary were thrilled to celebrate the release of Adeles new single Easy On Me and welcomed Maria, who performs as the singer onto the show. Following Adeles own weight loss, Maria had a gastric bypass and Alison praised her for honestly opening u about her transformation.

Maria admitted to being embarrassed when fans of Adele would mention her weight loss so she sped up the process of losing weight.

While she originally planned gastric surgery, Maria moved up the date as she worried shed no longer be able to work as an impersonator.

However, she insisted she lost weight for health reasons too, not just to work as Adele.

She added she still isnt happy with her weight and plans to lose more.

READ MORE:Kate Garraway addresses health concerns over sore eyes

I felt a huge amount of embarrassment if I'm gonna be completely and utterly honest with you. I was already singing and a couple of people came up to me saying, Have you seen Adele, how slim she is? Maria explained.

I had gained a lot of weight at that time, and it was that internal dread and I've gotta do this night after night.

It's such a personal thing for me.

Personally it's for my health, and I just wanted to feel more confident and not have that fear thing of Have you seen Adele.

Maria added: This is more for help as well. To go out and not be able to show your arms, thats just not nice.

I just get them out, Alison said turning to Dermot. Ive got flabby arms but I just get them out.

Maria continued: Arms are alright when youve got a bit of volume but when you take that away, theyre just saggy old balloons.

As Alison asked if it was for her health, Maria assured: Exactly, and this is more for health as well, and to go out and not be able show off your arms because of skin, it's not nice.

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Alison Hammond admits she wants to lose weight but is proud to get out flabby arms - Daily Express

By Jonathan Capriel (October 15, 2021, 9:32 PM EDT) -- A Missouri federal judge has dismissed design defect claims against Arena Pharmaceuticals over its weight loss medication Belviq, but the drugmaker couldn't shake allegations that its negligence and inadequate warnings caused a woman's breast cancer.

U.S. District Judge Greg Kays on Thursday granted in part Arena's motion to dismiss a lawsuit by Amy Davis, which claims her breast cancer diagnosed in November 2019 was caused by her use of Belviq. Judge Kays found that the suit failed to specifically identify what role Arena played in manufacturing the now discontinued drug.

The U.S. Food and Drug Administration recommended the drug be withdrawn...

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Penn Medicine researchers discovered that obese mice were able to shed 40 percent of their body weight by secreting fat through their skin.

PHILADELPHIA Treating obese mice with the cytokine known as TSLP led to significant abdominal fat and weight loss compared to controls, according to new research published Thursday in Sciencefrom researchers in the Perelman School of Medicine at the University of Pennsylvania. Unexpectedly, the fat loss was not associated with decreased food intake or faster metabolism. Instead, the researchers discovered that TSLP stimulated the immune system to release lipids through the skins oil-producing sebaceous glands.

This was a completely unforeseen finding, but weve demonstrated that fat loss can be achieved by secreting calories from the skin in the form of energy-rich sebum, said principal investigator Taku Kambayashi, MD, PhD, an associate professor of Pathology and Laboratory Medicine at Penn, who led the study with fourth-year medical student Ruth Choa, PhD. We believe that we are the first group to show a non-hormonal way to induce this process, highlighting an unexpected role for the bodys immune system.

The animal model findings, Kambayashi said, support the possibility that increasing sebum production via the immune system could be a strategy for treating obesity in people.

The Hypothesis

Thymic stromal lymphopoietin (TSLP) is a cytokine a type of immune system protein involved in asthma and other allergic diseases. The Kambayashi research group has been investigating the expanded role of this cytokine to activate Type 2 immune cells and expand T regulatory cells. Since past studies have indicated that these cells can regulate energy metabolism, the researchers predicted that treating overweight mice with TSLP could stimulate an immune response, which could subsequently counteract some of the harmful effects of obesity.

Initially, we did not think TSLP would have any effect on obesity itself. What we wanted to find out was whether it could impact insulin resistance, Kambayashi said. We thought that the cytokine could correct Type 2 diabetes, without actually causing the mice to lose any weight.

The Experiment

To test the effect of TSLP on Type 2 diabetes, the researchers injected obese mice with a viral vector that would increase their bodies TSLP levels. After four weeks, the research team found that TSLP had not only affected their diabetes risk, but it had actually reversed the obesity in the mice, which were fed a high-fat diet. While the control group continued to gain weight, the weight of the TSLP-treated mice went from 45 grams down to a healthy 25 grams, on average, in just 28 days.

Most strikingly, the TSLP-treated mice also decreased their visceral fat mass. Visceral fat is the white fat that is stored in the abdomen around major organs, which can increase diabetes, heart disease, and stroke risk. These mice also experienced improved blood glucose and fasting insulin levels, as well as decreased risk of fatty liver disease.

Given the dramatic results, Kambayashi assumed that the TSLP was sickening the mice and reducing their appetites. However, after further testing, his group found that the TSLP-treated mice were actually eating 20 to 30 percent more, had similar energy expenditures, base metabolic rates, and activity levels, when compared to their non-treated counterparts.

The Findings

To explain the weight loss, Kambayashi recalled a small observation he had previously ignored: When I looked at the coats of the TSLP-treated mice, I noticed that they glistened in the light. I always knew exactly which mice had been treated, because they were so much shinier than the others, he said.

Kambayashi considered a far-fetched idea was their greasy hair a sign that the mice were sweating out fat from their skin?

To test the theory, the researchers shaved the TSLP-treated mice and the controls and then extracted oils from their fur. They found that Kambayashis hypothesis was correct: The shiny fur contained sebum-specific lipids. Sebum is a calorically-dense substance produced by sebocytes (highly specialized epithelial cells) in the sebaceous glands and helps to form the skin barrier. This confirmed that the release of oil through the skin was responsible for the TSLP-induced fat loss.

The Conclusions

To examine whether TSLP could potentially play a role in the control of oil secretion in humans, the researchers then examined TSLP and a panel of 18 sebaceous gland-associated genes in a publicly-available dataset. This revealed that TSLP expression is significantly and positively correlated with sebaceous gland gene expression in healthy human skin.

The study authors write that, in humans, shifting sebum release into high gear could feasibly lead to the sweating of fat and weight loss. Kambayashis group plans further study to test this hypothesis.

I dont think we naturally control our weight by regulating sebum production, but we may be able to highjack the process and increase sebum production to cause fat loss. This could lead to novel therapeutic interventions that reverse obesity and lipid disorders, Kambayashi said.

This research was supported by grants from the National Institutes of Health (R01-HL111501, R01-10 AI121250, R01-AR070116, T32-HL07439), the Doris Duke Charitable Foundation, and the University of Pennsylvania Medical Scientist Training Program.

Penn researchers who contributed to this work include: Junichiro Tohyama, Shogo Wada, Hu Meng, Jian Hu, Mariko Okumura, Tanner F. Robertson, Ruth-Anne Langan Pai, Arben Nace, Christian Hopkins, Elizabeth A. Jacobsen, Malay Haldar, Garret A. FitzGerald, Edward M. Behrens, Andy J. Minn, Patrick Seale, George Cotsarelis, Brian Kim, John T. Seykora, Mingyao Li, and Zoltan Arany.

Penn Medicineis one of the worlds leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of theRaymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nations first medical school) and theUniversity of Pennsylvania Health System, which together form a $8.9 billion enterprise.

The Perelman School of Medicine has been ranked among the top medical schools in the United States for more than 20 years, according toU.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $496 million awarded in the 2020 fiscal year.

The University of Pennsylvania Health Systems patient care facilities include: the Hospital of the University of Pennsylvania and Penn Presbyterian Medical Centerwhich are recognized as one of the nations top Honor Roll hospitals byU.S. News & World ReportChester County Hospital; Lancaster General Health; Penn Medicine Princeton Health; and Pennsylvania Hospital, the nations first hospital, founded in 1751. Additional facilities and enterprises include Good Shepherd Penn Partners, Penn Medicine at Home, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health, among others.

Penn Medicine is powered by a talented and dedicated workforce of more than 44,000 people. The organization also has alliances with top community health systems across both Southeastern Pennsylvania and Southern New Jersey, creating more options for patients no matter where they live.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2020, Penn Medicine provided more than $563 million to benefit our community.

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Mice Treated with This Cytokine Lose Weight by 'Sweating' Fat - pennmedicine.org

Submitted by Penrose & Associates Physical Therapy

As we coached over 20 people through the eight-week weight loss program this past February here at Penrose & Associates Physical Therapy, I kept hearing how good everyone felt. The eating plan was really an anti-inflammatory way of eating. We didnt have any dairy or gluten for eight weeks. It was incredible what people learned about themselves once that was taken away and they eat more lean protein and lots of fiber. Skin was clearer, blood pressure improved, blood glucose improved, blood pressure dropped, people had improved sleep and energy, and joints felt so much better! It is science. Dairy and gluten are pro-inflammatory. That is very clear in the science, so no wonder we felt better.

Weight loss is a hard thing for most people. It requires change and new routines and it often means finding new favorite recipes and foods. It can feel overwhelming if you let it. However, anything new or different often is that way. It takes investing some time, money, and emotional energy into learning about food, recipes, metabolism, digestion and listening to your body. Our group provided a private Facebook group to share recipes and ask questions for substitutions to past favorite recipes. I learned how to cook things that are now weekly favorites! Trust me, as a business owner/employer, health care provider, mom of three very busy active boys, spouse, etc., I didnt think I had time to learn new things with regards to food, like grocery shopping differently or cooking differently. If I can do it, you can too! I just took it one day at a time and did the best I could knowing I was investing in my health and my future and my kids future. It wasnt perfect all the time and that was ok.

As a physical therapist we often see people struggling with weight gain due to their joints hurting so they cant move as well. I myself, as a health care provider, knew we were missing something in helping patients make better decisions with their overall health. I also knew my own cholesterol was climbing. Interestingly enough I found out with this program that when you eat too many starchy carbs your body will either deposit that as fat or create bad cholesterol. Well, my body turned those carbs into the bad cholesterol. Now that Im living this lifestyle my blood lipids are in the correct range and I feel better!

One woman with chronic osteoarthritis from a decades-old sports injury was able to resume hiking and rigorous gym workouts, activities that had been impossible just a few months earlier. My husband discovered that bread, pasta and potatoes make him puffy and lethargic, side effects of inflammation, so hes more conscious about avoiding those foods now. The energy boost alone is enough for him to stay clear from starchy carbs.

I have reached out to some clients that are still following the lifestyle and all the principles from the program we did in February 2021. One 64-year-old woman has lost 27 pounds over the course of 5 months and has gone down 2 full clothing sizes. But her favorite piece is that she is so happy that she finally feels good! Her gut health and joint health has improved with eating this way and overall she feels so much better.

Another 71-year-old woman from the group shared this: In one month I lost the COVID weight, my cravings for sugar and grains, and lowered my blood pressure by 30 points. I was sold! In month two I gained confidence in my own choices and self-control. I learned how to read a label quickly and efficiently, how important protein and fiber are at every meal, and a wealth of information from the many sources available from coaches to a dedicated Facebook page. I am very grateful I took the leap to join the TLS team and would recommend it to anyone who has tried to lose weight but failed with other programs.

I am not in the convincing business. If the time is right for you to achieve weight loss and wellness goals, then reach out for more information as we will be starting the next coaching group in September 2021. Email info@penrosept.com for more information regarding the program. We will send you a free report about key principles on weight loss and wellness that give you results.

This eight week program is for you if:

Dr. Jennifer Penrose is the owner of Penrose & Associates Physical Therapy and has been a physical therapist for 20 years. We are located at 1445 Galaxy Dr. NE Suite 301 in Lacey. Call us at 360.456.1444. We focus on helping people achieve mobility and longevity. We have free tips reports on the Penrose & Associates Physical Therapy website to help you get started right away.

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Penrose Physical Therapy Weight-Loss and Wellness Program: 'The Best Part of This Is I Feel So Good' - ThurstonTalk

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