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Another weight loss trend is making its rounds on social media this time in the form of a drink called "oatzempic." The name combines a reference to oats, one of the drink's ingredients, with a play onOzempic, the diabetes drug that's become popular for weight loss even though there's no prescription medication involved.

Some TikTok users claim the drink made with oats, water and lime juice can help someone lose up to 40 pounds in as little as 2 months. Experts, however, say to be wary of any trend that promises to purge pounds fast.

Lisa Valente, a registered dietitian and nutrition editor at Healthline, calls the trend "clever marketing for something that has no merit behind it."

"Blended oat drinks are not the same as prescription drugs. It also seems like a dangerous trend that promotes disordered eating and isn't nutritionally sound or based in science," she told CBS News.

Maggie Evans, a registered dietitian and care specialist with virtual cardiometabolic care platform 9amHealth, calls the trend an "extreme measure."

"As we've seen before, whether it'sMaster Cleanse, water fasts or other extreme diets, these (trends) may result in short-term weight loss results, but aren't the healthiest or most sustainable way to achieve that weight loss," she says.

TikTok has not blocked the term and hashtag (a step it appears to have taken for some other body image-related trends like "legging legs"), but when you search for "oatzempic" on the app, a banner appears saying "you are more than your weight," with links to resources.

"Fast weight loss can be possible when you restrict calories significantly, and this drink is quite low in calories, so if you are using it as a meal replacement, it may lead to fast weight loss," Valente explains. "However, I wouldn't recommend it because it is not a safe way to lose weight."

The Centers for Disease Control and Prevention says people who take the approach ofgradual, steady weight loss are more likely to keep the weight off than people who lose weight quickly.

"If a person stops the oatzempic diet, they're likely to regain the weight they lost and may end up in a yo-yo dieting cycle," says Dr. Avantika Waring, an endocrinologist and chief medical officer of 9amHealth. "We know that medically, losing and regaining weight repeatedly can actually make sustaining a healthy weight harder."

Waring says rapid weight loss can also result in:

"Underfueling the body can also lead to constipation, dehydration, dizziness and menstrual irregularities," she says.

Yes, oats are a heart-healthy whole grain that can be part of a balanced diet, experts say, and their high fiber content can also help us feel satisfied and fuller longer. But they're no "magic solution" for weight loss.

"We don't have any data to suggest it is effective for weight loss, and it's likely that having a blended oat drink for breakfast would be as healthy as eating a bowl of oatmeal without added sugars or topped with just fresh fruit which might also taste better!" Waring says.

Plus, experts note the oatzempic drink is missing key nutrients like protein, healthy fats, vitamins and minerals.

"There are other safer, healthier ways to lose weight that involve making small changes to your diet and don't remove entire foods or food groups," Valente says.

In general, false or misleading information can be rampant on social media. Experts say they've seen increased misinformation regarding weight loss in the past year, specifically related to the interest in drugs like Ozempic.

"Everything from 'nature's Ozempic' aka berberine, an ineffective and potentially dangerous supplement to overblown, fear-inducing side effects like 'Ozempic face' and 'Ozempic butt,'" Dr. James Wantuck, co-founder and chief medical officer of PlushCare,previously told CBS News.

Nutrition is also a nuanced topic, Valente adds, making it difficult to explain in a short, 10-second clip online.

"If you have questions about what you eat, I always recommend speaking with a health care professional rather than consulting social media," she says.

Sara Moniuszko is a health and lifestyle reporter at CBSNews.com. Previously, she wrote for USA Today, where she was selected to help launch the newspaper's wellness vertical. She now covers breaking and trending news for CBS News' HealthWatch.

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"Oatzempic" craze: Should you try the oat drink for weight loss? Experts weigh in. - CBS News

Summary

The 90 Day Fianc: The Single Life season 4 Tell All episodes have highlighted Natalie Mortdovtseva's jaw-dropping weight loss, but she's not the only franchise star who has lost weight. The series chronicles the lives of 90 Day Fianc franchise stars whose relationships didn't work out. For various reasons, these cast members have found themselves single and back in the dating world.

Since the series 90 Day Fianc first premiered in 2014, many of the franchise's cast members have lost weight during the process. Among them is the aforementioned Natalie, but she's not the only one who has lost weight over the years. Ashley Michelle, who is currently appearing on 90 Day Fianc: Happily Ever After? season 8, has also lost a considerable amount of weight. As has Natalie's 90 Day: The Single Life costar Tyray Mollett. Scroll down for information about 10 of the most dramatic 90 Day Fianc weight-loss journeys.

Ashley is a professional witch from New York, who married Manuel, a former construction worker from Ecuador, on 90 Day Fianc season 10. Though the couple had dated for seven years, Ashley and Manuel fought a lot, especially about money and how Ashley spent it. For his part, Manuel expected Ashley to help support his family back in Ecuador, including his two teenage sons, who she has never met. Manuel has also been suspicious about Ashley's witchcraft.

Ashleys romantic journey may be a constant struggle, but her lifestyle and fitness journey get better with every passing month. In March 2024, Ashley took to her Instagram and shared a deck of weight-loss comparison photos from throughout her journey. Some of the photos are of her earliest days at the gym. While others are of a dramatically slimmed down Ashley.

Ashley has lost about 100 pounds and the difference is dramatic.

Natalie Mordovtseva showed off her weight loss during part 2 of the 90 Day: The Single Life Tell All special. Natalie first appeared in 90 Day Fianc season 7, when she moved from Kyiv, Ukraine to Sequim, Washington, to marry Mike Youngquist, and it was a very rocky relationship. Despite the conflict between them, Natalie and Mike were able to get married before Natalie's 90-day K-1 fianc visa expired. During this dark time in her life, Natalie put on 20 pounds while she was still with Mike. Once their relationship ended and Natalie moved to Florida, then to Los Angeles, she started working on herself and lost 35 pounds.

30-year-old Tiffany Franco was first featured on 90 Day Fianc: The Other Way season 1, when she moved to South Africa with her young son, to marry Ronald Smith. They got pregnant almost right away, but Tiffany struggled to deal with Ronald's gambling addiction and criminal past. She also felt that she and her sons weren't safe in South Africa. Ultimately, she regretted her decision when Ronald couldn't support his family financially.

The Maryland native called Ronald an irresponsible father and husband and claimed that she had been taking care of her two kids all by herself.

After the divorce, Ronald moved on with someone new, while Tiffany decided to focus on her health and fitness instead. In June 2021, she underwent gastric bypass surgery to lose weight. When all was said and done, the 90 Day Fianc franchise star dropped 80 pounds. Tiffany showed off her newly transformed figure in a lacy black number.

90 Day Fianc: Happily Ever After? season 8 star Liz Woods worked as a waitress in San Diego when one of her customers, 90 Day Fianc star Big Ed Brown, asked her out on a date. Liz became Big Eds new girlfriend, and her whole life changed. During her relationship with Ed, Liz gained some weight. Ed would body-shame her, by looking at old pictures and asking if she'd ever be that thin again. In 2022, Liz went on a strict diet and exercise regimen and lost 22 pounds.

Tyray Mollett, star of 90 Day: The Single Life season 8, looks very different in his new photos after losing some weight. 33-year-old Tyray first appeared on 90 Day Fianc: Before the 90 Days season 6. Tray had met his girlfriend of four years, Carmella, on a dating app, and was hoping to get engaged. Though Carmella refused to get on video calls with him, Tyray didn't see the red flags.

Ultimately, it was revealed that Tyray had been catfished by a man named Christian from Barbados.

Since his appearance on the franchise, Tyray has focused on his health and on losing weight. Though it's unknown how much weight he lost, Tyray's Instagram posts reveal a much slimmer-looking man.

Fans were shocked by 90 Day Fianc season 10 star Devin Hoofman's dramatic weight-loss transformation after filming the season. Devin is a 23-year-old Arkansas native who married Korean man Seungdo Ham, AKA Nick, after meeting him on the dating app Tinder. Nick got in trouble after revealing his nickname for Devin was Piggy, because he thought Devin was a little chubby. He meant it as a term of endearment, but it bothered Devin and her parents. By the time the season finale rolled around, Devin had lost 30 pounds and looked like a different person.

90 Day Fianc: Love In Paradise star Aryanna Sierra has lost 100 pounds since starting her weight-loss journey, and her transformation has been extraordinary and inspiring. Aryanna talked about wanting to get healthier so that she could take care of her young son. Following her split from her ex-husband, Sherlon, the reality star focused on fitness and nutrition, inspiring others with her journey.

In January 2023, Aryanna posted an Instagram before and after weight-loss comparison, with a caption that reads, " Who knew you could look, but more importantly FEEL better at 27 than you did at 22. "

Fan favorite 90 Day Fianc franchise star Ariela Weinberg has lost 50 pounds since having her baby. The 33-year-old reality star first appeared in 90 Day Fianc: The Other Way, where she was pregnant with Biniyam Shibre's baby. At the time, Ariela was living in Ethiopia and struggling to adapt to her new life. During 90 Day Fianc: The Other Way season 3, Ariela had to bring her son, Aviel, back to the United States for hernia surgery, which was a difficult time for her marriage. They were able to make it work and, eventually, Biniyam moved to the United States and appeared on 90 Day Fianc season 9.

90 Day Fianc season 8 star Rebecca Parrott has slimmed down since her start in the franchise, as evidenced by her Instagram photos revealing her slimmed down figure. She has been open about her weight loss and cosmetic procedures, which Rebecca frequently posts about on Instagram with captions.

"Every day I feel better about my body."

Though she's a grandmother, Rebecca has always liked younger men. Her Moroccan ex was in his late teens when he dated Rebecca, who was then well into her 40s at the time. Rebecca then married Zied Hakimi, despite the Tunisian man being almost half her age.

38-year-old 90 Day: The Single Life season 4 star Veronica Rodriguez has lost a lot of weight over the course of the past few years. The reality TV star first debuted in 90 Day Fianc: Before the 90 Days. Veronica then appeared on 90 Days: TheSingle Life season 4, where she chronicled her relationship with Jamal Menzies. Veronica revealed that she had lost a total of 25 pounds, and it's clear that the successful lifestyle influencer looks much slimmer than she used to.

90 Day Star

Season

Total Weight Lost

Ashley Michelle

90 Day Fianc Season 10

100 pounds

Natalie Mortdovtseva

90 Day Fianc Season 7 90 Day: The Single Life Season 4

35 pounds

Tiffany Franco

90 Day Fianc:The Other Way Season 1

80 pounds

Liz Woods

90 Day Fianc: Happily Ever After? Season 8

22 pounds

Tyray Mollett

90 Day Fianc: Before The 90 Days Season 6 90 Days: The Single Life Season 8

Unknown

Devin Hoofman

90 Day Fianc Season 10

30 pounds

Aryanna Sierra

90 Day Fianc: Love In Paradise 90 Day Diaries

100 pounds

Ariela Weinberg

90 Day Fianc: The Other Way Seasons 2 & 3 90 Day Fianc Season 9

50 pounds

Rebecca Parrott

90 Day Fianc Season 8

Unknown

Veroncia Rodriguez

90 Day Fianc: Before The 90 Days season 3 90 Day: The Single Life season 4

25 pounds

90 Day: The Single Life airs Mondays at 8 p.m. EST on TLC.

Sources: Ashley Michelle/Instagram, Tiffany Franco/Instagram, Tyray Mollett/Instagram, Aryanna Sierra/Instagram, Rebecca Parrott/Instagram

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10 Jaw-Dropping 90 Day Fiance Weight-Loss Transformations - Screen Rant

Rebel reportedly writes that her past eating habits stemmed from witnessing her abusive late father, who died in 2013, lash out. Describing one specific incident with him, the actor says that he hit her as a child.

"'I'm going to choke you and kill you if you say one more thing, Melanie,'" Rebel, who was born Melanie before legally changing her name in 2002, says her father told her years ago. "'I'm going to throttle you.'"

"In those moments when I was worried or scared, I turned to food," she writes. "I think because I saw my mum do it. Everybody has a coping mechanism eating is mine."

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Rebel Wilson Reveals She Tried Ozempic To Lose Weight - BuzzFeed News

On TikTok, a woman blends a half cup of rolled oats with a cup of water and the juice of half a lime. She forces a smile and then hesitantly takes a sip. That, she says with a colorful flourish, is nasty.

The drink isnt meant to taste good; its supposed to be a weight loss hack.

Drink it every day, some influencers on social media claim, and you can lose a staggering 40 pounds in two months. Oatzempic, as its called, is a reference to the diabetes drug Ozempic, which belongs to a class of medications that have surged in popularity for their remarkable ability to help people lose weight.

Its riding on the coattails of these drugs, said Colleen Tewksbury, an assistant professor in nutrition science at the University of Pennsylvania.

But while oats are certainly nutritious, there is nothing magical about them for weight loss, said Emily Haller, a dietitian in the lifestyle medicine program at Trinity Health Ann Arbor in Michigan.

Oats are a good source of soluble fiber, especially one type called beta-glucan, which has been shown to lower blood cholesterol levels and reduce blood sugar spikes after meals, Ms. Haller said.

In general, consuming enough fiber (which most Americans dont) can also reduce your risk of developing heart disease and certain cancers, as well as support a healthy gut and regular bowel habits, she added.

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Can Oats Help You Lose Weight? Experts Weigh in On Oatzempic Trend - The New York Times

Published on Mar 30, 2024 06:48 PM IST

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Published on Mar 30, 2024 06:48 PM IST

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Published on Mar 30, 2024 06:48 PM IST

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Published on Mar 30, 2024 06:48 PM IST

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4 supplements for losing weight with PCOS: Dietitian shares tips - Hindustan Times

STEPHEN A. SMITH has undergone a dramatic physical transformation over the last year, after a series of health issues prompted him to make some major changes to his lifestyle. In a recent wide-ranging interview with biologist and 10X Health founder Gary Brecka on his

"That was me a year ago, ladies and gentlemen," he said, over an image of himself before he began his weight loss journey. "Yeah, that was your boy Stephen A. I can't even tell you how bad I was. Nearly 30 percent body fat. A cholesterol level over 300. And .1 point away from being a full-blown diabetic. And that was after I had Covid, which damn near killed me."

"This is a year later," he continued, showing off his visibly leaner appearance. "As you can see, times have changed."

While Smith tends to be a very private person outside of his work as a sports anchor, he felt compelled to share his health journey and be transparent, in the hopes that it will encourage others to take proactive action in their own lives.

Smith revealed that a year after beginning the process of changing his diet and increasing his physical activity, he is no longer pre-diabetic, his blood sugar is normal, and he's gained around 6 pounds of lean muscle.

He also addressed the rumors that his recent weight loss has been aided by the controversial diabetes medication Ozempic, which has become popular as a "diet drug" in wealthy circles.

"I've had people come up to me man, you know, that Ozempic must be good," he said. "I'm like, I didn't take that! I'm doing cardio six days a week, weightlifting five days a week, I take my supplements and vitamins, but I'm not doing that."

He added that his mindset with regards to exercise has also changed dramatically, saying: "I went from being conniving and slick and trying to avoid the gym to being pissed off that I missed going to the gym."

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Stephen A. Smith Opens Up About Weight Loss Transformation - Men's Health

Everybody was happy except my GI tract

Vicki Webb Pouncey, a 58-year-old breast cancer patient from Melbourne, Florida, tried three of the drugs over the last few years, under the supervision of both her nurse practitioner (who discovered Pouncey was insulin resistant) and her oncologist, who worried her extra weight might drive a recurrence.

She first tried the low-dose pill Rybelsis, but after several weeks had zero results. So she tried Wegovy using a discount coupon for a six-month supply.

On the Wegovy, I lost 40 pounds right away and my numbers all started to improve, she said. Cholesterol, blood sugar, insulin resistance that all looked better. But then the coupon ran out and I couldnt get any more so I went back on the Rybelsis.

Again, her weight loss stalled. So her providers suggested she try Ozempic. Immediately, pounds started to come off again.

I lost weight and my labs looked great, she said. Everybody was happy except my GI tract.

The drugs can have considerable side effects. Ozempic lists the most common as nausea, diarrhea, abdominal pain, vomiting and constipation. Zepbound lists the same plusindigestion, injection site reactions, fatigue, allergic reactions, belching, hair loss and heartburn. It also mentions the potential for kidney failure; gallbladder problems; pancreatitis; low blood sugar; changes in vision and depression.

At first, Pouncey only had nausea and diarrhea a few days after her weekly shot; then it started happening more often.

The drug absolutely diminished her food cravings and her sweet tooth, she said, and she felt healthier, at least for a while. But Ozempic may have been too effective.

There were days when I had to make myself eat, she said. At one point, I think I became malnourished because of all the nausea and diarrhea. But my lab numbers were beautiful so I stayed on it.

After several months, though, the GI issues became a daily ordeal and she started to have pain on her right side. Now, there were only good hours, not good days, she said.

She stopped the Ozempic and went to her doctor about the pain. He ordered a CT scan, thinking shed developed pancreatitis, one of the noted side effects. Instead, the CT scan found metastatic breast cancer in her liver, which led to more scans and more tumors.

The scans also detected nodules on her thyroid, which have yet to be biopsied. The metastatic breast cancer treatment is her primary concern, she said.

She absolutely does not attribute her metastatic recurrence to the weight-loss drugs.

I understand the difference between correlation and causation, she said. The thyroid nodules are the only thing I would associate with it. And it lists that in the risk factors on the label.

Even with the all the suffering, Pouncey said the drugs were beneficial. All told, she lost 80 pounds; her cholesterol, insulin resistance and blood sugar improved dramatically and she was even free of the joint pain caused by her anti-hormone drugs.

Once I got rid of processed sugar and carbs, my joint pain almost resolved itself, she said. And losing the weight took the pressure off my knees.

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The new weight-loss drugs and cancer - Fred Hutchinson Cancer Center

The Gila monster is a poisonous North American lizard that measures around 50 centimetres and sports a distinctive coat of black and orange scales. This lethargic reptile, which mostly dwells underground and eats just three to four times a year, is the unlikely inspiration for one of pharmas biggest blockbusters: a new generation of weight-loss drugs that has patientsand investorsin a frenzy. Originally made for diabetes, evidence is growing that they also have benefits in diseases of the heart, kidney, liver and beyond.

Since the late 1980s scientists believed that a gut hormone called glucagon-like peptide-1 (GLP-1), which is secreted by the intestines after a meal, could help treat diabetes. GLP-1 increases the production of insulin (a hormone that lowers blood-sugar levels) and reduces the production of glucagon (which increases blood-sugar levels). But GLP-1 is broken down by enzymes in the body very quickly, so it sticks around for only a few minutes. If it were to be used as a drug, therefore, patients would have faced the unwelcome prospect of needing GLP-1 injections every hour.

In 1990 John Eng, a researcher at the Veterans Affairs Medical Centre in The Bronx, discovered that exendin-4, a hormone found in the venom of the Gila monster, was similar to human GLP-1. Crucially, the exendin-4 released after one of the monsters rare meals is more resistant to enzymatic breakdown than GLP-1, staying in its body for hours. It took more than a decade before exenatide, a synthetic version of the lizard hormone, created by Eli Lilly, an American pharma giant, and Amylin Pharmaceuticals, a biotech firm, was approved to treat diabetes in America. This breakthrough spurred other firms to develop more effective and longer-lasting GLP-1 medications as a treatment option for diabetes, beyond injections of insulin.

Scientists had also been aware that GLP-1 had another side-effect: it slowed the rate of gastric emptying, which allows food to stay in the stomach for longer and suppresses appetite. But the potential weight-loss benefits were not seriously pursued at first. It was only in 2021 that Novo Nordisk, a Danish firm, showed data from a clinical trial where overweight or obese patients were put on a weekly dose of its GLP-1-based diabetic drug, semaglutide, which was then being marketed under the name Ozempic, for 68 weeks. The results were dramaticparticipants had lost 15% of their body weight, on average.

The medicines that mimic the GLP-1 hormone then became blockbusters. With close to half of the worlds population expected to be obese or overweight by 2030, according to the World Obesity Federation, demand for these drugs is surgingBloomberg, a data provider, estimates that these medications will hit $80bn in yearly sales by then. The market is projected to grow by 26% per year in the next 5 years, compared with16% per year for oncology drugs and 4% per year for immunology medicines, the two other biggest areas.

So far only three GLP-1 drugs have been approved to treat obese or overweight individuals: liraglutide and semaglutide, developed by Novo; and tirzepatide, made by Lilly. But the market has already attracted a wave of competitors (see chart 1). Bloomberg tracks close to 100 wannabe drugs in the development pipeline. Most new therapies hope to outdo semaglutide and tirzepatide by crafting drugs that are easier to take, cause fewer side-effects or deliver more effective weight loss (see chart 2).

Start with convenience. Both semaglutide and tirzepatide are injections that need to be taken weekly. Stop the dose and most of the weight returns within a year. Amgen, a large American biotech firm, is developing an anti-obesity drug that relies on doses once a month, and hopes the weight-loss effects will last even after treatment ends. AMG133 activates receptors for GLP-1 while blocking receptors of glucose-dependent insulinotropic polypeptide (GIP), a hormone secreted in the small intestine in response to food intake that stimulates the production of both insulin and glucagon. The company is now conducting clinical trials to find out if patients can, over time, be gradually weaned towards smaller doses.

Switching from injections to pills would also make the drugs a lot more tolerable for those who dislike needles. Novo is working on an oral version of semaglutide that works just as well as its jabs. But the pill requires 20 times the amount of the active ingredient as the injection, and must be taken daily. With semaglutide in short supply, Novo has had to push back the oral versions launch. Lilly also has a daily pill that targets GLP-1 receptors called orforglipron in late-stage clinical trials.

Another drawback of GLP-1-based medicines is the nausea and vomiting that frequently accompanies their use. Zealand Pharma, a Danish biotech firm, is developing a drug that is based on a different hormone called amylin, produced in the pancreas along with insulin in response to food intake. But unlike GLP-1, which suppresses appetite, amylin induces satiety, or the feeling of fullness after a meal.

Adam Steesburg, boss of Zealand, says that in most people a hormone called leptin is released from fat tissue that signals to the brain that the body is full. Obese individuals are insensitive to that hormone. Clinical studies have shown that analogues of amylin can make people sensitive to leptin again, helping them to stop eating earlier. Feeling full, rather than lowering appetite, may also reduce the feeling of nausea. Mr Steesburg says that results from early-stage trials suggest that its drug could achieve similar weight loss as GLP-1 drugs, but with less nausea and vomiting.

Besides pesky injections and nausea, a bigger concern is that patients on these drugs do not just shed fat, they also lose lean muscle mass. Some patients drop almost 40% of their body weight in lean mass, a serious concern for older patients. To counter this, companies are trying out, alongside GLP-1 drugs, medicines originally designed to treat muscle atrophy.

Regeneron, an American pharma company, is testing drugs that block myostatin and activin, proteins that inhibit muscle growth in the body. Taken with semaglutide, the combination can potentially boost the quality of weight loss by preserving lean muscle. Similarly, BioAge, a California-based biotech, is testing a drug that activates the apelin receptor that can be taken alongside Lillys tirzepatideApelin, a hormone secreted after exercise that acts on skeletal muscle, the heart and the central nervous system to regulate metabolism and promote muscle regeneration. In obese mice, the combination led to greater weight loss compared to tirzepatide alone, while preserving lean body tissue.

The slimming drugs arent just for shedding pounds. Because obesity is linked to over 200 health issues, including strokes, kidney problems and fatty liver, GLP-1 drugs are proving useful for more than just obesity.

A recent clinical trial by Novo that ran for five years and enrolled more than 17,500 participants found that semaglutide cut the risk of serious heart issues like heart attacks, strokes, or death from heart disease by 20%. Novo believes that the heart benefits of the treatment are not due to weight loss alone, because the reduction in the risk of cardiovascular problems occurred early, before patients lost weight. In March semaglutide was approved by the US Food and Drug Administration for reducing the risk of heart disease in obese or overweight people, the first time a weight-loss medication has been approved for this purpose. Results from another clinical trial have shown that semaglutide reduced the risk of kidney-disease-related events by 24% in patients with type-2 diabetes.

Another weight-loss drug, survodutide, being developed by Boehringer Ingelheim, a German drug company, and Zealand, has shown promising results in being able to treat a serious liver condition called metabolic dysfunction-associated steatohepatitis (MASH). This is caused by the build-up of excess fat in the liver and can lead to liver cancer or liver failure. In a recent trial of 295 patients, 83% saw significant improvement in their condition when treated with survodutide, compared with 18% of those on a placebo. Survodutide targets receptors for GLP-1 and glucagon. Waheed Jamal from Boehringer Ingelheim says that there is evidence that glucagon breaks down more fat in the liver compared with GLP-1 and reduces fibrosis (build up of excessive scar tissue in the liver).

While a lot of focus has been on the action of these medicines on improving metabolic health, scientists are now uncovering that these drugs also engage with the brain and immune system, by interacting with GLP-1 receptors in the brain.

Daniel Drucker, a diabetes researcher at Mount Sinai Hospital in Toronto, found that in mice suffering from extensive inflammation throughout the body, GLP-1 drugs reduced the condition, but only when the receptors in the brain werent blocked. When the brain receptors in mice were either blocked or genetically deleted, the anti-inflammatory properties of the drugs were lost. This suggests that the GLP-1 drugs tame inflammation by acting on the brain cells.

For some this suggests that these drugs might be useful for treating brain disorders that are characterised by inflammation, such as Alzheimers disease and Parkinsons disease, both of which are characterised by inflammation in the brain. Since 2021, Novo has been conducting a clinical trial involving more than 1,800 patients to test whether semaglutide helps patients with early stages of Alzheimers. This study is expected to be completed by 2026.

Dr Drucker sees the anti-inflammatory qualities of GLP-1 medications as key to their versatility. He notes that besides Alzheimers and Parkinsons, chronic inflammation is a factor in many complications for people with type-2 diabetes and obesity, and affects organs like the kidneys, heart, blood vessels, and liver. If these drugs eventually help in treating these conditions, Dr Drucker believes that their inflammation-reducing properties could explain part of their success.

The appetite-suppressing effects of these drugs has also raised interest in their ability to curb cravings for other substances. Researchers in Denmark investigated the effect of GLP-1 drugs on people with alcohol-use disorder. In the study of 130 people, they found no difference between patients who used the drugs (alongside therapy) compared with those using a placebo. However there was a reduction in alcohol consumption in obese patients. When the researchers looked at the brain activity of the patients by showing them pictures of alcoholic drinks, for those in the placebo groups the reward centres of their brains lit up. For patients on GLP-1 drugs, the activity of the brain in the areas associated with reward and addiction was attenuated, indicating a direct brain effect. Some researchers are now actively exploring whether the drugs might have an impact on how people use other addictive substances such as tobacco or marijuana.

All of these findings are still early. Developing new drugs is costly and time-consuming. There are steep failure rates. Successes in the lab may not work in people, and results in small groups may not replicate in larger ones. But with the potential to treat dozens of conditions well beyond obesity and diabetes, hope around the new drugs will only grow.

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Could weight-loss drugs eat the world? - The Economist

Summary

After losing over 400 pounds, 1000-lb Sisters star Tammy Slaton has been experimenting with the boho fashion aesthetic and posting them on social media. When the series premiered in 2020, Tammy weighed 725 pounds at her heaviest, but she has since gone through an extraordinary weight-loss journey. After a health scare that landed her in the hospital and a medically induced coma, Tammy decided she had to change her life. She checked herself into rehab, where, through diet and exercise, she lost enough weight to qualify for bariatric surgery.

After losing 400 pounds, the 1000-lb Sisters season 5 star is living an entirely different life. Before Tammy lost weight, her mobility was limited, and her size made her a prisoner in her own home. Now, she travels with her family, tries new things, and celebrates new milestones at every turn. Tammy has especially enjoyed experimenting with style and fashion since losing weight, trying on clothes and looks that weren't available to her at her previous size.

In January, Tammy posted a TikTok of herself singing a duet with fellow TikTok creator @Crazyjen1998. In the side-by-side split screen, the women are singing along to a remake of Rachel Platten's "Fight Song." The power anthem is the perfect background tune to the last few years of Tammy's life. Despite the triumph of losing weight, Tammy suffered a tragedy during 1000-lb Sisters season 5, when her husband, Caleb Willingham, sadly passed away from complications due to obesity. She had to fight hard to stay on track with her weight-loss despite being devastated by the loss.

" Looking good girl!! Proud of you."

In January, Tammy posted a TikTok clip of herself showing off her outfit of the day. In the clip, she's wearing a wildly colorful tie-dye top that screams flower power. In a nod to another of Tammy's weight-loss milestones, she's also wearing jeans, which would have been impossible before Tammy lost all of the weight. At her former size, she would never have been able to find a pair of denim jeans. In the clip, Tammy lifts her shirt slightly to show off that her jeans have a zipper and front button closure, as opposed to an elastic waistband.

" You are doing great and you look AMAZING!"

Fans of the 1000-lb Sisters star took to the comment section to offer their support to Tammy. "Looking good girl!! Proud of you," wrote one fan, while another reiterated, "you look amazing!! I love that shirt!!" Though the internet isn't known for kindness in the comment section, the Slatons have always had a great relationship with their supportive fan base. Another fan wrote, "You are doing great and you look AMAZING!"

In a TikTok Tammy posted in July 2023, she's wearing fun rope bracelets and is ready for spring in her floral printed top. The 1000-lb Sisters star is also wearing layered boho chic necklaces, including the treble clef necklace she has often been spotted wearing lately. Her full face of skillfully applied makeup shows how much slimmer Tammy's face is than it used to be before she lost over 400 pounds. There are no comments in the comment section because it's locked, but the clip has over 5,000 likes.

Tammy isn't the only Slaton who has gotten in on the weight-loss action since the show premiered. Her sister and fellow 1000-lb Sisters star, Amy Slaton, has lost over a hundred pounds as well. Additionally, Tammy and Amy's step-brother, Chris Combs, has lost over 150 pounds, while their step-sister, Amanda Halterman, has lost over 300 pounds. Though the Slatons have lost over a thousand combined pounds over the years, they are all still planning and working on losing more weight while inspiring others with their incredible journeys.

Tammy Slaton

Lost 400+ pounds

Diet, exercise, weight loss surgery

Amy Slaton

Lost 125+ pounds

Diet, exercise, weight loss surgery

Chris Combs

Lost 150+ pounds

Diet, exercise, weight loss surgery

Amanda Halterman

Lost 300+ pounds

Weight loss surgery

Misty Slaton

Unknown

Wants weight-loss surgery

In August 2023, Tammy posted a video clip of herself to Instagram, and in the clip, Tammy is singing along with Taylor Swift's "Shake It Off." The lyrics "Haters gonna hate, hate, hate, hate, hate, hate" are intended for the haters in the comment section commenting negatively about Tammy's body since losing weight. Many of the criticisms come from people who point out that Tammy has a lot of extra skin since losing weight, while others want Tammy to fix her teeth. Too many people have forgotten that if they can't say anything nice, it's best to say nothing at all.

" she cant win guys. when she was overweight you hated her and then when she loses weight you make fun of the way her body looks. What is she supposed to do?"

Though some people in the comments still had plenty to say about the extra skin Tammy has since she has lost over 400 pounds. The positive comments far outnumber the negative comments. One Instagram user said it best, writing, "she cant win guys. when she was overweight you hated her and then when she loses weight you make fun of the way her body looks. What is she supposed to do?" The 1000-lb Sisters star is shaking off all the criticism with a smile on her face.

1000-lb Sisters seasons 1-5 can be streamed on MAX and Discovery+.

Sources: Tammy Slaton/TikTok, Tammy Slaton/TickTock, Tammy Slaton/TikTok, Tammy Slaton/Instagram

1000-lb Sisters follows sisters Amy Salton-Halterman and Tammy Slaton in their home in Dixon, Kentucky, covering their daily lives, weight loss attempts, and subsequent weight loss surgery. The show covers such moments as attempts to have children, medical visits, and dramatic emergency room visitations. The family wrestles with supporting their daughters and their weight loss efforts while struggling with their own life troubles.

Continued here:
1000-Lb Sisters: Tammy's Best Hippie Outfits After Extraordinary Weight Loss Milestone (You'll Love Her Boho Clothes) - Screen Rant

People who lost weight and gained it back repeatedly a phenomenon commonly called weight cycling that is often associated with yo-yo dieting were significantly more likely to experience negative cardiovascular events like heart attack and stroke, regardless of other cardiac risk factors and average overall weight, according to a study published March 21 in JAMA Network Open.

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Our findings indicate that on a population level, individuals with greater variability in BMI [body mass index] are at higher risk for adverse cardiovascular events as compared to others with less BMI variability, says a coauthor of the study,Zakaria Almuwaqqat, MD, MPH, a hospital medicine doctor and postdoctoral fellow in cardiovascular disease at Emory Healthcare in Atlanta.

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The study used data from two large cohorts, the Million Veteran Program of more than 92,000 U.S. veterans, and 65,000 people from the UK Biobank.

The veteran group had an average age of 57, and 88 percent were men. Ten percent were Hispanic, 24 percent were Black, and 65 percent were white. The average BMI was 30, and BMI measurements were taken multiple times over an average of 10 years. At least three measurements were needed for an individual to be included in the study.

The UK group also had an average age of 57, and 41.5 percent were men. All the subjects were white, and the average BMI was 27 significantly less than the veteran group average.

Weight cycling was measured by averaging the BMI measurements over the course of the study. For example, if one subject had three different BMI measurements of 30, 31, and 32, the average would be 31 and the standard deviation would be 1.

Participants were followed for about four years. During that time, researchers tracked the number of heart attacks, strokes, and deaths due to heart disease.

The researchers found that weight cycling was associated with an increased risk of negative cardiovascular events in all racial and ethnic groups. In the veteran cohort, each 1 standard deviation increase in BMI variability was associated with a 16 percent higher risk of cardiovascular events, which included nonfatal heart attack, stroke, and deaths from heart disease.

In the UK Biobank cohort, each 1 standard deviation increase in BMI variability was associated with an 8 percent higher risk of cardiovascular death.

We have found that the greater change in BMI correlates with a higher risk of adverse cardiovascular events in a dose-dependent manner, says Dr. Almuwaqqat.

Because the study used each subjects individual weight to calculate the standard deviation, it is difficult to pinpoint the exact amount of weight fluctuation that is considered high risk, since it is very patient specific, says Nishant Shah, MD, a cardiologist at Duke Health in Durham, North Carolina, who was not involved in the study.

Instead, consider rapid shifts over a course of time for example, down 20 pounds from baseline and then up 20 pounds from baseline over a six month period to be of more cardiovascular risk than a sustained 20 pound weight loss, according to the study results, he says.

Investigators also found that the associated risk was different depending on race and ethnicity. The association between weight cycling and stroke was stronger in Black participants, and the link between weight cycling and cardiovascular death was higher in white subjects. Because the association wasnt as strong in the UK group, the risks could be influenced by race or sex, the authors noted.

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Its unclear exactly why weight cycling may increase the risk of heart disease, says Dr. Shah. There are many hypotheses. For instance, the rapid changes in body weight can add extra stress to the heart, may lead to vascular dysfunction, or lead to more inflammatory fatty tissue development, he says.

Its also possible that rapid changes in weight could be caused by other medical conditions like cancers, infections, or inflammatory disorders, which could add further stress if a person already has an underlying heart condition, says Shah.

The findings here dont mean that people should abandon all efforts to achieve their healthy weight, says Shah. There are plenty of benefits of weight loss, and people should still strive to find ways they can successfully have sustainable weight loss, he says.

Obesity can lead to several serious comorbidities, includinghigh blood pressure, high cholesterol, and type 2 diabetes, that can worsen your overall heart disease risk, he points out.

It is also very difficult to make many conclusions based on one study alone. We need more data to better understand the magnitude of BMI variability that is most concerning, he says.

Its also worth noting that a much higher proportion of males than females participated in the veterans cohort, and there may have been other risks or contributing factors that the researchers didnt account for that could have led to the findings, says Shah.

This study didnt look at people on GLP-1s. The participants had BMI changes that were not caused by medications, and so this question cant be answered from this data, says Almuwaqqat.

The use of GLP-1 is generally associated with cardiovascular risk reduction, and the impact of weight fluctuations is not clear among these individuals, he says.

GLP-1 medications have several benefits when they are prescribed and taken appropriately, says Shah. At the end of the day it is a benefit-to-risk evaluation that is very specific to the patient. Patients should discuss with their healthcare provider about what is right for them, he says.

The rest is here:
Weight Cycling Increases the Risk of Heart Attack and Stroke - Everyday Health

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