Search Weight Loss Topics:

Page 58«..1020..57585960..7080..»

Home » Page 58

INDIANAPOLIS A gym on the citys west side is once again welcoming clients after gunfire rang out inside the facility on Tuesday night, injuring two people.

The shooting occurred just inside the front doors of VASA Fitness, located at 6965 W. 38th St., at around 9 p.m.

Two victims, a juvenile and an adult, were shot but are expected to make a full recovery.

The gym reopened for the first time since the shooting on Saturday morning. Management says they are doing everything they can to make their staff and clients feel as comfortable as possible.

We feel we are an extremely safe environment, and we are partnering with local law enforcement so they can keep our community safe, Layne Nordquist, VASA Fitness Regional Director, said.

Nordquist says VASA employees go through extensive emergency training to help them prepare for any crises that may occur.

If clients are feeling uneasy about returning to the gym, Nordquist says employees will give them a tour of the gym and discuss the facilitys safety plans with them.

Police are still searching for the suspect. Anyone with information is asked to call Crime Stoppers at 317-262-8477 (TIPS).

See more here:
VASA Fitness on Indy's west side reopens Saturday following double shooting - WRTV Indianapolis

Read More..

Two men have been ever present in Anistons professional lifefrom the days of the Rachel to nowher hairstylist, Chris McMillan, and colorist Michael Canal. McMillan is the man behind that infamous hairstyle some 28 years ago, and he still cuts and styles her hair now. Likewise, Canal still works his honey-caramel, sun-kissed magic on the actors famous mane to this day.

This content can also be viewed on the site it originates from.

Like so many fellow A-listers, Jennifer Lopez included, Aniston sees the queen of the Hollywood power brow, Anastasia Soare, founder of Anastasia Beverly Hills, to keep her arches in check. In an interview with Vogue, Soare previously likened the effects of her treatments to a mini facelift.

This content can also be viewed on the site it originates from.

The woman behind Anistons luminous makeup is Angela Levin, whose signature is natural glam. Levin also works with everyone from Michelle Williams and Reese Witherspoon to Glenn Close.

Like anyone else who remains so lean, lithe and toned in their fifties, Aniston works hard to achieve that body. The good news is that she enjoys exercise, and has previously said she feels really beautiful post workout, because Ive taken care of my body, my endorphins are going, my blood is pumping. Im taking care of the one body I have. To that end, she mixes it up with boxing, yoga and cardio, which she does for at least 20 minutes each day, and keeps a treadmill, and spin and elliptical bikes at home. She finishes her workouts with an infrared sauna.

Her trainer, Leyon Azubuike, founder of the US boxing gym Gloveworx, also puts her through her paces. Their sessions start with a 15 minute yoga warm-up and incorporate everything from skipping rope to jumping jacks and lots of core work yep, those defined abs are courtesy of lots of planking.

See the original post here:
The Beauty And Fitness Routine Jennifer Aniston Follows To Look That Luminous - Vogue

Read More..

indystar.com wants to ensure the best experience for all of our readers, so we built our site to take advantage of the latest technology, making it faster and easier to use.

Unfortunately, your browser is not supported. Please download one of these browsers for the best experience on indystar.com

Read the original here:
Suspect opens fire in VASA fitness gym in Indianapolis, 2 shot - IndyStar

Read More..

Ive worked alongside trainers who, when he moment they completed their exercise-related degree was the moment they stopped investing any effort in continuing education. They decided they knew enough and didnt think that there was a need for continuing education for fitness professionalsand it showed in their eventual career struggles, lack of skills evolution, and disengagement in the field to the point they instead poured time into multilevel marketing schemes in the false hope of retiring by age 35.

For the majority of us whove invested in making others better, resting on our laurels isnt an option.

Butdo you need an advanced degree (or even a degree) in exercise science, nutrition, or related fields to have a successful career in fitness? The short answer is no.

The long answer is also no, though such a degree can open valuable doors and set you up for success. Look no further than Dr Mike Israetel, PhD in Sports Physiology and co-founder of Renaissance Periodization. Mike may also be one of the most well-educated people in nutrition, yet holds no formal degrees in nutrition or dietetics. Contrast this with Mikes partner Nick Shaw, the CEO of RP, highly knowledgeable and successful in his own right who holds a Bachelor of Arts in Sports Management.

For many coaches, pursuing a degree or adding an advanced degree in fitness or nutrition is time and cost prohibitive. Thankfully we have a rich array of free, low cost, and high value moderate cost options available to allow coaches to grow and thrive. Continuing education for fitness professionals should be a bedrock of any successful career.

Heres a breakdown of some of the best resources for continuing education for fitness professionals.

Most coaches dont start with the disposable income to pile on seminars and certifications. Fortunately most information exists free on the internet. Early in my career I read the library of strength and conditioning, nutrition, and muscle building articles on T-Nation, Muscle and Fitness, Bodybuilding.com, and Precision Nutrition. I poured over the websites of their regular writers for more articles, like Tony Gentilcore, Ben Bruno, Christian Thibaudeau, Lee Boyce, and Krista Scott-Dixon. Their examples inspired me to start writing.

Early in my career I found Dr. Layne Norton and binged his early YouTube videos on nutrition and found his old podcast Physique Science Radio with cohost Sohee Lee. This led to Jeff Nippards podcasts, Danny Lennons Sigma Nutrition Radio, Kevin Larrabees FitCast, and later Luka Hocevars Vigor Life Podcast. Sigma and Vigor are still going strong to this day and Ive even appeared as a guest on Vigor. Jordan Syatt and Mike Vacantis How to Become a Personal Trainer, is a must listen for aspiring coaches. I loved podcasts so much I founded one with a friend over six years ago and it carries on today as The Lift Free and Diet Hard Podcast.

While much of YouTube is sensational info-tainmentlong on entertainment and short on education (think CT Fletcher, Rich Piana (RIP), and BroScience/Dom Mazzetti)many credible evidence-based fitness professionals have a strong foothold on YouTube. Luka Hocevar, Jeff Nippard, Renaissance Periodization, and many other fitness professionals and brands have grown successful channels, driving substantial business their way.

YouTube is also a goldmine for the business and media skills many coaches neglect. A deep dive into Alex and Leila Hormozis podcasts and YouTube might alone be a more surgical business education than a four-year degree (speaking from experience with my Bachelor of Commerce).

This should also get every fitness professional thinking about creating their own long-form content, whether writing articles, hosting a podcast, or filming YouTube. This can open incredible doors to brand development and a foundation for social media growth. Writing for my own website led to numerous published writing opportunities, evidenced here.

Not everything is free and people dont always value free things. Just ask any trainer whos offered free programs to friends. Adherence rates are mediocre at best. It helps to have a little skin in the game.

Buying booksyes, booksis one of your best investments. Less expensive than most formal course, books, however, require the investment of time. Audiobooks, like podcasts, will turn your daily commute and cooking time into an ongoing university style education. I reserve my limited physical reading time for textbooks and other resources I cant consume on audio, or for content creation like writing, recording, or presentations. This leaves audiobooks as my main outlet for averaging around 80 books a year (work up to listening on faster speeds). Books advance your education in sales, business, marketing, communication, coaching, philosophy, public speaking, writing, productivity, nutrition, and a wide array of other valuable skills for a successful career.

Some of my top recommendations for any fitness professional include:

(Theres many more educational books out there. Please shoot me a message on Instagram and Ill personally recommend books to suit your current needs.@andrewcoatesfitness.

As your business grows and you have more disposable income, its wise to invest back into your skills and career growth. Theres a strong argument that investment in skills that increase your earning potential is a better investment than the stock market. This isnt advice against regularly putting away savings for your retirement, but accelerating your income growth puts you on a faster road to financial freedom down the road.

Carefully selecting courses, seminars, and certifications can be a valuable and surgical way to attain critical knowledge.

Many trainers begin by added deeper nutrition knowledge to broaden the depth of service they offer for clients. Some trainers want to feel confident and qualified to discuss general nutrition with clients while others wish to add formal nutrition coaching to their offering. Some of the most popular and reputable nutrition courses include Precision Nutrition Level 1 and Martin MacDonalds Mac-Nutrition Uni.

Chasing certifications for the sake of pulling up more credentials is a fools errand and poor use of your time and money, but carefully chosen certifications can provide important skills to distinguish you as a caring, confident, and skilled coach.

Some the best certifications Ive personally taken include:

A certification is wise when its the most efficient road to acquiring important skills.

One of the most uniquely high leverage ways to thrive in the industry is to attend seminars and industry conferences. While you can gain knowledge and skill, perhaps even more fulfilling is the opportunity to connect with industry leaders and like-minded peers on the same journey you are.

Some of the most valuable opportunities in my career have come from meeting and supporting other coaches in my travels. Ive made a point of flying out from the frozen north of Edmonton Canada at least a few times a year to surround myself with new and old industry friends.

Im slated to speak at Raise the Bar in Dallas, Texas Feb 23-24, alongside a lineup of industry leaders including Molly Galbraith, Luka Hocevar, Nick Shaw, Jordan Syatt, and Kelsey Heenan.

Also on the near horizon, The Real Coaches Summit in Las Vegas, where Im returning to support my friend the host Aram Grigorian and spend time with many industry friends.

These events changed my life by connecting me with like-minded peers whove become lifelong friends, while also getting quality time with industry leaders. I spent six years working in a commercial gym under their rigid systems. Being surrounded by different coaches with different business structures helped shed restrictive thinking and grow in ways I didnt understand where possible. Some of those connections led to great podcast guests, invitations to appear on podcastrs, invitations to write for big publications, and public speaking opportunities.

Coaches can also hire mentors to accelerate their development. Mentorship programs are more prevalent than ever with many being outrageously expensive and not always delivering on value. A great mentor can warp you ahead on important business and career choices and systems, while a bad one can drain your coffers and leave you discouraged. Take your time to find the right mentor or program that aligns with your values and offers the specific skills you need. Youre paying a premium price to bypass a lot of time consuming and potentially inefficient self exploration.

One lifetime can barely scratch the surface of all the things we could possibly know about health, muscle building, fat loss, human psychology, and all the other important career skills we believe we need. Then consider the complex depth of coaching in various niches like training and nutrition in sports, combat sports, military and paramilitary organizations, special forces, bodybuilding, powerlifting, olympic weightlifting, CrossFit, and more.

The smartest PhDs are still learning. New research emerges and old beliefs are challenged and refined or discarded with new information. All the while even the most trusted evidence based academics and coaches dont agree with each other on 100% of all details. If we wait to have all the answers before we begin helping people, we would never start. Experience is also one of the best teachers.

You can study with every waking hour and be useless to help others without practical experience. Experience takes time and opportunity. The opportunity cost of gaining experience may be earning lower hourly rates in the short term. The goal is gain as much experience as possible as quickly as possible so you out yourself in a position to earn a greater livelihood and have more resources for life and to invest back into your education.

Great coaches never stop learning.

View post:
Guide To Continuing Education For Fitness Professionals - Muscle & Fitness

Read More..

Home AIRLINE NEWS Qatar sports Day: Join in the fitness fun at Hamad Intl Airport

Monday, February 12, 2024

Favorite

This year, Hamad International Airport (DOH) is marking Qatar National Sports Day with a lineup of exciting fitness activities throughout its terminal.

Passengers of all ages, whether departing or transferring, can enjoy a diverse array of interactive fitness events. From a Leopard Crawl to a Tyre Challenge, Sack Race, Hula Hoop Competition, Tennis Tetherball, Paper Plane Competition, Hang & Squat Challenge, and Runway Dash, theres something for everyone.

As the gateway to Qatar, Hamad International Airport proudly showcases the countrys celebrations and initiatives to its millions of passengers. Aligned with the objectives of Qatar National Sports Day, this initiative aims to promote the importance of sports and fitness in leading a healthier lifestyle.

The airports transformation into a sports hub reflects Qatars broader initiatives and celebrations. By actively involving passengers in these activities, Hamad International Airport extends the spirit of Qatar National Sports Day to its travelers, providing them with an opportunity to engage in the nations festivities.

All travelers are warmly invited to participate in these activities and help raise awareness about the significance of health and fitness.

Since its opening in 2014, Hamad International Airport has consistently ranked among the worlds best airports, thanks to its passenger-centric approach. Serving as a multifaceted lifestyle destination, the airport offers a wide range of amenities, including fine dining, art collections, retail outlets, entertainment areas, sports facilities, and relaxation spaces.

Back to Page

View post:
Qatar sports Day: Join in the fitness fun at Hamad Intl Airport - Travel And Tour World

Read More..

Anyone who exercises regularly -- or at least tries to -- knows that every day is different. After an exhausting work trip, for example, you probably aren't as ready for a workout as you would be after getting plenty of sleep over the weekend. Or perhaps you had a particularly intense day at the gym on Monday and still aren't fully recovered by Wednesday.

Google's Fitbit is hoping AI can help with scenarios like these as it explores bringing the buzzy technology to its fitness app. Fitbit co-founder James Park, who is leaving the company due to a reorganization of Google's hardware division, introduced this idea October by announcing Fitbit Labs. The upcoming program will use AI to provide deeper health insights, such as answering questions about why your run may have been harder today than it was yesterday. But Ajay Surie, group product manager at Google, shared additional details about how generative AI will influence the Fitbit app more broadly.

Read more: Samsung's Galaxy S24 Ultra Could Be Doing So Much More With AI

According to Surie, the company is looking at how generative AI can be used for providing personalized activity and exercise recommendations that are specific to the actual user. It's another signal that tech giants are looking for ways to infuse generative AI, or AI that can answer questions or create content when prompted after being trained on data, into the tech gadgets we use everyday.

"We also see a huge potential for AI to help us drive the right recommendations for the goals you want to set," he said. "Because one of the biggest problems that we see in health, and I have this problem too, is getting users to stay focused and sticking with what they're trying to achieve."

Watch this: 2023's Top Smartwatches and Wearables of the Year

Surie referenced exercise goals as a potential example. The World Health Organization recommends that adults get 150 minutes of physical activity each week. But that can be challenging for those who are new to exercise, while experienced athletes may need a higher goal. He sees "huge potential" in AI to help set the right targets.

"We want to help people keep track of their goals and stay on track, but also adjust their goals where relevant," he said.

Another possible example involves taking a user's current state into account when making recommendations or providing advice. That would mean being able to tailor daily guidance based on the amount of sleep you've had recently or whether you've been sick. Or it could mean providing tips for maintaining a training regimen even when you've had a bad rest day. However, these are just examples meant to illustrate the types of features Fitbit hopes to eventually provide.

"Those are the types of things we'd like to do over time," Surie said. "This is our vision, and it's going to take time to get there."

Part of why Fitbit redesigned its app last year was to set the stage for Fitbit Labs by making the app more customizable and personal. The Today tab, for example, now has a specific "focus," which is essentially a group of statistics that sit near the top of the screen for prioritizing specific goals, like being more active or sleeping better.

But many longtime Fitbit users felt the redesign hampered rather than helped their fitness ambitions. Following the new app's debut in the fall, Fitbit's community forums were filled with negative comments from users about how the new look made it hard to find certain metrics or export data among other issues. Fitbit also removed beloved social features like challenges and groups last year.

Fitbit addressed certain complaints by re-adding some missing features, like the battery percentage for a connected Fitbit device in the Today tab and step streak counts in the iOS app. But new user complaints are still surfacing, with comments as recent as early February present in the Fitbit community forum at the time of writing.

"The process the team followed was, we wanted to really react as quickly as we could," Surie said when asked about how the Fitbit team handled the feedback about the redesign. "So we engage quite heavily with the community of users in our forums to sort of listen to their feedback, try to give them a sense of what we were going to do and then follow up as quickly as we could in terms of getting things turned around."

Read more: Google VP: Here's How AI Will Slowly But Surely Take Over Your Phone

Fitbit's ambitions are another sign that generative AI is making its way to health tracking gadgets, following the technology's influence on smartphones, productivity software and search engines. Apple, for example, is rumored to be developing an AI-powered health coach that could provide suggestions based on Apple Watch data, according to Bloomberg. Samsung is also considering creating some type of virtual assistant that can help users navigate health data in the Samsung Health app.

"We think the concept of a digital system that helps you to navigate and understand the context and navigate them to solutions are going to be necessary," Hon Pak, vice president and head of the digital health team for the mobile experience business at Samsung Electronics, said in a previous CNET interview. "And what form factor that's going to be is to be determined. And it may vary based on person to person, right? Some people just probably want audio; some people want a video on the TV."

Fitbit Labs will be available only for Premium subscribers when it eventually launches in 2024. Surie couldn't say whether that will always be the case, but he did mention that the company will evaluate which features should scale beyond the paywall on a case-by-case basis. The goal behind Fitbit Labs is to test certain features and collect feedback from users before rolling them out widely, potentially providing a glimpse into Fitbit's future.

"Throughout this, we obviously want to make sure that we do this responsibly, especially in the health space," Surie said. "It's one thing to go to Netflix and watch a bad movie. And it's a totally other thing to get a recommendation that is relevant to health and get inaccurate advice."

Editors' note: CNET is using an AI engine to help create some stories. For more, seethis post.

View post:
How Fitbit Wants AI to Help You Reach Your Fitness Goals - CNET

Read More..

That scathing description came just as Bidens aides were trying to explain away the presidents most recent verbal gaffes in which he mixed up the heads of state and recalled recent conversations with world leaders who died long ago.

During a pair of New York fundraisers on Wednesday night, Biden twice described conversations he said he had in 2021 with European leaders at the G7 meeting in the U.K., which took place just months after the U.S. Capitol insurrection. At both Manhattan events, Biden said that former German Chancellor Helmut Kohl, who died in 2017, had asked him about the Jan. 6 riot and his reaction if people stormed the British Parliament and killed officers to stop the election of a prime minister.

And just days earlier, during a campaign event outside of Las Vegas, Biden mixed up Franois Mitterrand, the former French president who died in 1996, for French President Emmanuel Macron.

Democrats have defended Biden but also questioned the age and fitness of Bidens likely Republican rival, Donald Trump, himself facing an indictment over his handling of classified materials.

Beyond his recent high-profile mix-up of Nikki Haley and Nancy Pelosi, Trump, 77 has repeatedly said he is running against Barack Obama, and not Biden, and that he feared that the nation may soon enter World War II, a conflict that has been over for nearly 80 years.

Bidens mistakes underscore what critics say are the most persistent political threats to the presidents reelection bid: his age and the fear among voters that he is not mentally fit to hold office again.

If you turn on Fox News, theyre talking about a bumbling, fumbling Joe Biden. If you go on TikTok, Instagram, there are tons of videos making fun of his age, said a Democratic donor adviser, granted anonymity to discuss a sensitive issue. Its just consistently out there, so the more this happens, the more it feeds it.

Then came Thursdays release of the special counsel report. It noted investigators found insufficient evidence to charge the president for mishandling classified documents during Bidens time as vice president. But it also said that Bidens memory appeared to have significant limitations and that he did not remember, even within several years, when his son Beau died in 2015. And it said that Biden could not remember when he was vice president or the details of a debate about sending additional troops to Afghanistan.

After the report was released, White House lawyers disputed Hurs characterizations of Bidens memory, and argued that he had gone outside his scope and remit. They said he was gratuitous in his focus on the presidents memory. Republicans were biting. Speaker Mike Johnson, Majority Leader Steve Scalise (R-La.), GOP Whip Tom Emmer (R-Minn.) and Conference Chair Elise Stefanik (R-N.Y.) in a joint statement, said the comments on Bidens memory were among the reports most disturbing parts.

A man too incapable of being held accountable for mishandling classified information is certainly unfit for the Oval Office, they added.

Polls have consistently shown deep voter concerns about Bidens age. A new NBC poll released this week found a combined 76 percent of voters say they have major (62 percent) or moderate (14 percent) concerns about Biden lacking the necessary mental and physical health to be president for a second term. Perhaps most worrisomely for the president, 81 percent of independents and 54 percent of Democrats say they have major or moderate concerns about Bidens fitness for a second term.

On whether they have the same concerns about Bidens likely GOP opponent, Donald Trump, the poll found 48 percent of voters said they did.

The former president also has made a series of recent gaffes. When he confused Haley for Pelosi, it prompted Haley, his lone remaining GOP primary rival, to suggest that Trump was in decline and no longer up for the job.

Before the release of the special counsel report, the White House was asked about the presidents misstatements about the foreign leaders and dismissed them as nothing more than slips. As it relates to the names and what he was trying to say, many people, elected officials, many people, you know, they can misspeak sometimes, White House press secretary Karine Jean-Pierre said Thursday.

Biden campaign spokesperson Kevin Munoz argued it is very clear what will matter most to voters in November.

Like we did in 2020, well remain focused on those issues that matter to families and how its only because of President Bidens deep experience that Democrats up and down the ballot are able to run on such a historic and popular agenda, Munoz said in a statement.

Biden has previously made other errors involving the deceased. Most infamously, he mistakenly called out for Rep. Jackie Walorski at a September 2022 event, though the Indiana Republican had died in a car crash the month before. Last year, Biden mixed up Chinese President Xi Jinping with Deng Xiaoping, the Chinese leader who died in 1997.

Both Biden and Trump are vulnerable to age-related mistakes, said Dan Sena, a Democratic consultant who led the Democratic Congressional Campaign Committee in 2018. But I dont completely buy into the ageism argument against either of them that making gaffes will decide this. Itll come down to the larger meta-narrative about those who are looking backward and those who are looking forward.

Even so, I dont envy the management position theyre constantly in, Sena added. Bidens ability to connect is one of his greatest strengths, but at the same time, it exposes some of his vulnerabilities.

Democrats argue that the presidents age is baked in for most voters, who are keenly aware of his advanced age. They point to Bidens victory in 2020, when he was 77, as evidence he has already overcome the issue.

If [Republicans] spend all this money on saying hes old and his age makes him out-of-touch, who does that move? Who is on the fence on that issue? People have already made up their minds on this, said Kevin McKeon, a Democratic consultant.

The Biden campaign has, at times, used humor to try to neutralize the issue, a strategy Democratic donors have urged him to lean into. On his 81st birthday, Bidens campaign posted a photo of the president in front of a blazing birthday cake, joking about his 146th birthday.

Others, like Democratic strategist Mark Longabaugh, believe that the president has to just go on being the president, showing he has the vigor to be the president, but that means some of these mistakes are going to occasionally happen.

Bidens pitch in 2020 was that he was the one Democrat who could beat Trump and the incumbent president has privately suggested that he believes that holds true again for this November.

But his age prompted a presidential primary challenger. Rep. Dean Phillips (D-Minn.) launched a long-shot bid against Biden that is entirely centered on how the presidents age weakens Democrats chances in beating Trump.

Im attacked for being honest and saying the quiet part out loud the part DC insiders only do in private, Phillips posted on X, including a clip of Biden from earlier this week, when he appears to forget the name of Hamas, when answering a question about the Israel-Hamas conflict.

But shame on all of you pretending everything is ok. You are leading us and him into a disaster, and you damn well know it, Phillips wrote.

Those in Bidens inner circle note that fatigue forces Biden to expend more energy combating his lifelong stutter and contribute to verbal slips.

But while many in Bidens orbit bristle at the narrative about his age, they also believe they can neutralize it. They argue that voters dont make their decisions about whom to support based on age, and instead are more concerned about a candidates values and accomplishments.

Bidens advisers also make the case that he was slammed by Trump and his GOP allies over his age and mental fitness during the 2020 campaign, and that they overcame those attacks in part by pointing to his experience. Now, they said, they can point to major legislative victories as part of an updated plan as well as a robust travel schedule that compares favorably to his predecessors and includes two recent stops in war zones.

Here is the original post:
Age isn't just a number. It's a profound and growing problem for Biden. - POLITICO

Read More..

President Joe Biden held a press conference Thursday to address concerns over his mental fitness, during which he referred to Egyptian leader Abdel Fattah el-Sisi as the "president of Mexico."

"As you know, initially, the president of MexicoSisidid not want to open up the gate to allow humanitarian material to get in," Biden said in an attempted reference to Gaza's border with Egypt. "I talked to him. I convinced him to open the gate."

The remark came just hours after a special counsel report said Biden could not recall when he served as vice president or when his son Beau died. The report followed an investigation into the president's mishandling of classified documents.

Special Counsel Robert Hur declined to bring charges against Biden, stating that a jury would find the president to be "a well-meaning, elderly man with a poor memory."

Biden addressed the report Thursday, saying, "I'm well-meaning, and I'm an elderly man, and I know what the hell I'm doing."

Not long before Biden confused Egypt with Mexico, a reporter yelled to him, "Why are you confusing the names of world leaders?"

Originally posted here:
WATCH: Biden Responds to Mental Fitness Concerns by Confusing Egypt With Mexico - Washington Free Beacon

Read More..

Scientists looking at peptides as a potential tool for muscle development research may be curious about the most practical molecules currently available. Several peptides have been linked to hypothesized properties like the potential increase in muscle cell proliferation and fiber development.

In this comprehensive guide on peptides studied in relation to muscle cells, we have compiled the latest data to aid researchers. This in-depth review covers everything from peptide action mechanisms to potential efficacy and existing research data.

Studies suggest that Sermorelin is one of the smallest functional peptides that may promote the production of growth hormone (GH) by binding to growth hormone-releasing hormone (GHRH) receptors. Sermorelin had regulatory clearance for its effect of boosting GH, an anabolic hormone, which has been suggested to increase growth hormone secretion.

Research suggests that the non-peptide MK-677 (ibutamoren) may mimic the effects of the endogenous hormone ghrelin, much like peptide-based growth hormone secretagogues (GHSs). Researchers are considering it a possible research candidate in the context of growth failure and GH insufficiency. Data suggests it may promote muscle development and lean mass gain, nevertheless.

Investigations purport that Tesamorelin may be an appropriate research peptide in the context of fatty tissue abnormalities in HIV/AIDS research studies; the peptide Tesamorelin has been hypothesized to increase growth hormone release via the gonadotropin-releasing hormone receptors. According to studies, Tesamorelin seems to increase the density and size of muscle cells, which might prevent substantial losses of muscle mass.

Molecules constituted of amino acids linked by peptide bonds are known as peptides. This results in complex molecular structures whose characteristics are determined by their unique sequences of amino acids. Peptides are tiny proteins that usually include two to fifty amino acids.

Their potential role as important cellular communicators, hormone modulators, and growth regulators are only a few of the physiological processes that pique the curiosity of scientists. Artifically synthesized peptides built of sequences of amino acids that often mimic native analogs, have emerged as a result of this.

Synthetic peptides often undergo strategic alterations to improve their selectivity, and potential effectiveness compared to their analogs. Hundreds more are undergoing extensive investigation.

Multiple study peptides have suggested promising results in increasing contractile force within muscles and muscle cell proliferation. Research suggests that certain peptides may promote muscle development by increasing GH synthesis and secretion, affecting insulin-like growth factor-1 (IGF-1) expression. The primary anabolic mediator of GH, IGF-1, is primarily synthesized in the liver in response to GH and then released into the bloodstream. Also, GH may promote IGF-1 production inside muscle tissue in either a paracrine or autocrine fashion.

Increasing muscle protein synthesis (MPS) and decreasing muscle protein breakdown (MPB) are two ways in which IGF-1 might promote muscle anabolism, as suggested by studies:

It is also possible that certain peptides function by interacting with inhibitors or regulators of muscle development. To avoid myostatins restricting effects on muscle development, researchers are looking for peptides such as Follistatin 344. Investigations purport that myostatin inhibitors and other peptides may have complex interactions within the organism, which need further research.

There is promising data that peptides may enhance GH, which might increase IGF-1 levels and promote muscle development. At the moment, this is hypothesized to be accomplished via two related classes of peptides:

Scientists interested in further studying the potential of any of the compounds mentioned in this article may find the highest quality research peptides on the Core Peptides website. Please note that none of the substances mentioned in this article have been approved for human or animal consumption.

See the article here:
Metabolic Profile Studies Involving Peptides - The Teal Mango

Read More..

An article published this week in the prestigious journal Nature Medicine documents what is believed to be the first evidence that Alzheimers disease can be transmitted from person to person.

The finding arose from long-term follow up of patients who received human growth hormone (hGH) that was taken from brain tissue of deceased donors.

Preparations of donated hGH were used in medicine to treat a variety of conditions from 1959 onwards including in Australia from the mid 60s.

The practice stopped in 1985 when it was discovered around 200 patients worldwide who had received these donations went on to develop Creuztfeldt-Jakob disease (CJD), which causes a rapidly progressive dementia. This is an otherwise extremely rare condition, affecting roughly one person in a million.

CJD is caused by prions: infective particles that are neither bacterial or viral, but consist of abnormally folded proteins that can be transmitted from cell to cell.

Other prion diseases include kuru, a dementia seen in New Guinea tribespeople caused by eating human tissue, scrapie (a disease of sheep) and variant CJD or bovine spongiform encephalopathy, otherwise known as mad cow disease. This raised public health concerns over the eating of beef products in the United Kingdom in the 1980s.

Read more: People who lived in the UK in the 'mad cow disease' years may now be able to give blood. The risk of vCJD is tiny

Human growth hormone (hGH) is produced in the brain by the pituitary gland. Treatments were originally prepared from purified human pituitary tissue.

But because the amount of hGH contained in a single gland is extremely small, any single dose given to any one patient could contain material from around 16,000 donated glands.

An average course of hGH treatment lasts around four years, so the chances of receiving contaminated material even for a very rare condition such as CJD became quite high for such people.

hGH is now manufactured synthetically in a laboratory, rather than from human tissue. So this particular mode of CJD transmission is no longer a risk.

The Nature Medicine paper provides the first evidence that transmission of Alzheimers disease can occur via human-to-human transmission.

The authors examined the outcomes of people who received donated hGH until 1985. They found five such recipients had developed early-onset Alzheimers disease.

They considered other explanations for the findings but concluded donated hGH was the likely cause.

Given Alzheimers disease is a much more common illness than CJD, the authors presume those who received donated hGH before 1985 may be at higher risk of developing Alzheimers disease.

Alzheimers disease is caused by presence of two abnormally folded proteins: amyloid and tau. There is increasing evidence these proteins spread in the brain in a similar way to prion diseases. So the mode of transmission the authors propose is certainly plausible.

However, given the amyloid protein deposits in the brain at least 20 years before clinical Alzheimers disease develops, there is likely to be a considerable time lag before cases that might arise from the receipt of donated hGH become evident.

Read more: Size of brain area linked with cognitive decline even in people with no other warning signs of Alzheimers disease

In Australia, donated pituitary material was used from 1967 to 1985 to treat people with short stature and infertility.

More than 2,000 people received such treatment. Four developed CJD, the last case identified in 1991. All four cases were likely linked to a single contaminated batch.

The risks of any other cases of CJD developing now in pituitary material recipients, so long after the occurrence of the last identified case in Australia, are considered to be incredibly small.

Early-onset Alzheimers disease (defined as occurring before the age of 65) is uncommon, accounting for around 5% of all cases. Below the age of 50 its rare and likely to have a genetic contribution.

The Nature Medicine paper identified five cases which were diagnosed in people aged 38 to 55. This is more than could be expected by chance, but still very low in comparison to the total number of patients treated worldwide.

Although the long incubation period of Alzheimers disease may mean more similar cases may be identified in the future, the absolute risk remains very low. The main scientific interest of the article lies in the fact its first to demonstrate that Alzheimers disease can be transmitted from person to person in a similar way to prion diseases, rather than in any public health risk.

The authors were keen to emphasise, as I will, that Alzheimers cannot be contracted via contact with or providing care to people with Alzheimers disease.

Read more: Young-onset Alzheimers can be diagnosed from as early as 30 and the symptoms are often different

See the original post:
Alzheimer's may have once spread from person to person, but the risk of that happening today is incredibly low - The Conversation

Read More..

Contact Us Today

Page 58«..1020..57585960..7080..»

Home » Page 58