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May 19

Study finds evening fast helps mice lose weight

WASHINGTON In an age of long commutes, late sports practices, endless workdays and 24/7 television programming, the image of Mom hanging up her dish towel at 7 p.m. and declaring the kitchen is closed seems a quaint relic of an earlier era.

It also harks back to a thinner America. And that may be no coincidence.

A new study, conducted on mice, hints at an unexpected contributor to the nations epidemic of obesity and, if later human studies bear it out, a possible way to have our cake and eat it too, with less risk of weight gain and the diseases that come with it.

Just eat your cake or better yet, an apple earlier. Then wait 16 hours, until the next morning, to eat again.

We have to come up with something that is a simple alternative to calorie counting, said Satchidananda Panda, a regulatory biologist at the Salk Institute in La Jolla, Calif., who led the study published online Thursday by the journal Cell Metabolism.

Panda and his team put groups of mice on different eating regimens for 100 days. Animals in two of the groups dined on high-fat, high-calorie chow. Half of them were allowed to eat whenever they wanted, and nibbled on and off throughout the night and day. The other mice had access to food only for eight hours at night, when they were most active.

The difference was astonishing. Even though they ate a high-fat diet, the mice who wrapped up their eating day early and were forced to fast for 16 hours were lean almost as lean as mice in a control group who ate regular chow. But the mice who noshed on high-fat chow around the clock became obese, even though they consumed the same amount of fat and calories as their counterparts on the time-restricted diet.

It is suggestive that scholars in the diabetes, obesity and other areas related to heart disease need to test this issue further in animals and humans, said Barry Popkin, nutrition expert at the University of North Carolina.

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Study finds evening fast helps mice lose weight

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