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Testosterone therapy improves sexual functions – India New England
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New York Long-term testosterone replacement therapy improves both sexual and urinary functions as well as quality of life for men suffering from a condition due to deficiency of the hormone, according to a study.
Testosterone is a steroid hormone involved in the regulation of sexual function, urinary health and metabolism as well as a number of other critical functions.
For most men, testosterone concentration declines slowly with age and may not cause immediate major symptoms.
However, some men may experience a host of signs and symptoms constituting a clinical condition called Testosterone Deficiency (TD), or male hypogonadism, which is attributed to insufficient levels of testosterone.
Office Portrait of MED Prof. Dr. Abdulmaged TraishPhoto by Vernon Doucette for Boston University Photography
As a result, they experience symptoms as varied as erectile dysfunction, low energy, fatigue, depressed mood and an increased risk of diabetes.
The study, published in the Journal of Urology, investigated the effects of long-term testosterone replacement therapy on urinary health and sexual function as well as quality of life in men with diagnosed, symptomatic testosterone deficiency.
More than 650 men in their 50s and 60s enrolled in the study, some with unexplained testosterone deficiency and others with known genetic and auto-immune causes for their hypogonadism.
It is thought that testosterone treatment in men may increase prostate size and worsen lower urinary tract symptoms, said Abdulmaged Traish, Professor of Urology at Boston University School of Medicine in the US.
However, the researchers discovered that despite increased prostate size in the group that received testosterone therapy, there were fewer urinary symptoms such as frequent urination, incomplete bladder emptying, weak urinary stream and waking up at night to urinate.
In addition to these subjective improvements, the researchers conducted objective testing that showed that those men treated with testosterone emptied their bladders more fully.
Finally, testosterone treatment also increased the scores patients received on assessments of their erectile/sexual health and general quality of life, the study said.
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Testosterone therapy improves sexual functions - India New England
The Testosterone-Fueled Presidency – Common Dreams
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Oh, those authoritarian strongmen! They are so much more masculine than we ordinary males, so much more alpha, so much more physically powerful. At 73, Mao Zedong allegedly swam the Yangtze River at a pace that would have been faster than that of Sun Yang, the 2012 Chinese 1,500-meter Olympic gold medal winner. There were even photos that claimed to document the septuagenarians achievement.
This summer, papers were abuzz about Vladimir Putin's shirtless Siberian vacation, during which he engaged in a series of macho exercises, highlighted by chasing a razor-toothed pike underwater for two hours before spearing it. In Turkmenistan, the government recently released a video of President Gurbanguly Berdymukhammedov in camouflage throwing knives at targets, firing a machine gun and standing on the tarmac, calling in an airstrike.
And then we have our own president, Donald Trump, he of the "I guarantee you, there's no problem" genitalia. His short-lived communications director, Anthony Scaramucci, introduced himself by enumerating his boss' unparalleled athletic feats; more Brady than Tom Brady, more Curry than Steph Curry, more Speith than Jordan Speith:
"I've seen this guy throw a dead spiral through a tire. I've seen him at Madison Square Garden with a topcoat on. He's standing in the key and he's hitting foul shots and swishing them, okay? He sinks 30-foot putts. I don't see this guy as a guy that's ever under siege."
(By the way, Scaramucci originally said "3-foot putts," but the White House later amended it. Seriously.)
All of this would just be more comical Trumpian absurdity, severe overcompensation, if it weren't for one thing: Trump's hypermasculinity is bringing us perilously close to a military confrontation with North Korea. Former Defense Secretary Leon Panetta even had the nerve to ask whether Trump's bluster was a result of his thinking that Kim Jung-Un was questioning the president's manhood, which is not something I ever recall being raised in any previous presidential discussion.
But just think about it: We may go to war because our president has problems with his masculinity, and war is his method of dealing with it. You don't really need Freud to look at the shape of a nuclear weapon and see where Trump is coming from.
There has been a resurgence of an ugly misogyny that resents women and hopes to put them back in "their place"a resentment that our president represents, amplifies and legitimizes. That there is a war of men against women in America today is undeniable, and, as said, it isnt limited to men at the bottom of the totem pole.
But it isn't only what has been dubbed Trump's "Toxic Masculinity Syndrome" that's at issue. It is America's TMS. Apparently, to judge from Trump's support, tens of millions of white male Americans suffer from the same syndrome, which is why Trump clearly feels enabled to flirt with war. He knows these guys will have his back. What are a few hundred thousand casualties in the service of demonstrating your maleness?
In analyzing Trump's white male base, especially those in the Rust Belt, pundits have fastened onto their sense of economic disempowerment. These men are undergoing a status crisis, which is why Trump scores so well among white uneducated voters and also, arguably, why these white men are so hostile to liberals, whom they see as snooty elitists.
The problem with this analysis is that college-educated white males also supported Trump, as did white males who made over $50,000which isn't to say that these groups dont suffer from a status crisis, only that the crisis isn't a function of education or economics.
I suspect it is in some large measure a function of something that has received far too little attention in the media: the threat that women pose to traditional male dominance.
There has been a resurgence of an ugly misogyny that resents women and hopes to put them back in "their place"a resentment that our president represents, amplifies and legitimizes. That there is a war of men against women in America today is undeniable, and, as said, it isnt limited to men at the bottom of the totem pole.
For example, however much the right defends the memo by former Google engineer James Damorethat women are not discriminated against in Silicon Valley, but just happen to have a different mindset from successful tech menthe thrust of that memo was yet another way to marginalize women and justify their inequality. Silicon Valley is notorious for hatred of womengeek retribution.
To anyone who is the least bit enlightened, which doesn't include our president, such thoughts are antediluvian. But to the right wing, efforts to marginalize women are foundational. Conservatism is not just fundamentally an anti-feminist movement, a designation it embraces proudly, but an anti-women movement. Under the rubric of "traditional values," it is predicated on preventing males from losing their dominance. In fact, almost nothing exercises conservatives as much as women's encroaching power. And while this misogyny is generated by white men for white men, white women, a majority of whom also voted for Trump, are accomplices, apparently resenting women who refuse to submit to the male power structure.
Again, much of this was discounted, even among liberals, in last year's presidential election, and when Clinton herself adduced sexism as one reason for her loss, pundits tended to pooh-pooh it. They preferred economic and social sources for white male disaffection, possibly because these just sounded better.
But it is no stretch at all to view the election as a gender status contest between a conventional blustering male egotist and a powerful woman. Nor is it a stretch to see the election not as one in which a rich, powerful alpha male was vanquishing a woman with the temerity to challenge the social order, but as one in which an old, overweight, doughy male with ill-fitting suits, ties down to his knees and a bad haircutin short, the very personification of the ignorant, unregenerate male troglodytewas vanquishing that woman and everything she represented. It wasn't, as many said, hatred of Hillary that beat her. It was hatred of women.
Scholars have long seen the affinity between hypermasculinity and fascism, and the way gender roles get translated into politics. Indeed, in many ways, fascism and "alt-right" movements are the political versions of hypermasculinity born of a fear of female empowerment. Christina Wieland, of the University of Essex, has written a book titled The Fascist State of Mind and the Manufacturing of Masculinity, one chapter of which is suggestively titled "Masculinity and its discontents."
In the same vein, Michael Kimmel at Stony Brook University's Center for the Study of Male and Masculinities has looked at the confluence of masculinity endangerment and far-right movements, recently focusing on white male Trump supporters with their simmering resentments and sense of humiliation.
Kimmel sees the relationship between male endangerment and violence, and spoke recently about his own conclusions, as well as those of author James Gilligan. "He argued that shame and humiliation underlie basically all violence: 'Because I feel small, I will make you feel smaller,'" he said. This certainly speaks to domestic violence. It is only now, however, with Trump, that it speaks to international violence, threats of nuclear war.
I would posit that Trump connects with his base not because they feel some surge of vicarious power through his power. He connects with them because they see in him the same insecurity, humiliation and emasculation they feel, and see in him the same unhinged response they have.
I would posit that Trump connects with his base not because they feel some surge of vicarious power through his power. He connects with them because they see in him the same insecurity, humiliation and emasculation they feel, and see in him the same unhinged response they have. Because he feels small, he is going to make the world smaller. He is going to show them! Disempowered men get that.
Which is where North Korea comes in. Putting aside the harm that white men who feel emasculated can do to women, a testosterone-fueled presidency is an extremely dangerous one. It leads almost inevitably to confrontation precisely because it has nothing to do with strategic policy, only with personal slights.
Trump has always had a masculinity problem. It is why so much of his discourse is consumed with insisting on his malenesson his sexual prowess, on his irresistibility to women, on feminizing his opponents as weak, on his fake bravado, on objectifying and denigrating women, and now his threats to North Korea. He's even threatening Venezuela.
Methinks the man protests too much. Even so, it seems beyond belief that Trump would take us to war to show just how big a man he is. But, then, so did a Trump presidency seem beyond belief. It only goes to show that when you fear women enough and can rouse hatred against them in similarly threatened males, anything can happennone of it good. Nukes, anyone?
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The Testosterone-Fueled Presidency - Common Dreams
How testosterone regulates singing in canaries – Phys.Org
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Testosterone controls specific features of birdsong in two distinct regions of the canary brain that resemble the human motor cortex, according to a study published in The Journal of Neuroscience. The research points to a role for sex hormones in the regulation of this complex behavior that is more precise than merely increasing motivation to sing.
Canaries form a new song in the fall that becomes stable during the spring breeding season, when testosterone levels are high. This process parallels vocal development in humans, which begins with babbling in the first months of life and stabilizes after puberty.
Beau Alward and colleagues investigated the effects of testosterone on birdsong by blocking its receptors in two key brain regions involved in singing. Using male canaries, the authors found that the robust nucleus of the arcopallium (RA) regulates the production of song units such as syllables and trills (rapid repetition of a particular syllable type), while HVC regulates syntactical features such as how often a syllable type is used and the duration of trills. These results suggest that testosterone contributes to the canary's ability to learn a new song each year.
Explore further: Testosterone in male songbirds may enhance desire to sing but not song quality
More information: Dissociable effects on birdsong of androgen signaling in cortex-like brain regions of canaries, Journal of Neuroscience (2017). DOI: 10.1523/JNEUROSCI.3371-16.2017
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How testosterone regulates singing in canaries - Phys.Org
Fmr. Air Force Secretary: Trump Needs to ‘Tone Back the Testosterone’ – Mediaite
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Whats President Donald Trumps biggest strategic blunder on North Korea? In the estimation of one former Department of Defense official, its a surplus of male hormones.
Appearing on MSNBC Monday, Deborah Lee James who served as Secretary of the Air Force under President Barack Obama called on Trump to pursue diplomatic options with North Korea.
I would tell him to tone down the bluster and the rhetoric from the top, James said. And work with these new sanctions that we have both China and Russia on board to enforce. And ensure that the enforcement happens in an air-tight fashion. Double down on diplomacy.
Then, in closing, she added, Lets tone back the testosterone.
Trump, of course, ratcheted up the rhetoric on North Korea last week in a series of statements to the media and on Twitter. Most notably, Trump warned he would unleash fire and fury on North Korea if they escalated their nuclear threat.
North Korea best not make any more threats to the United States, Trump said. They will be met with fire and fury like the world has never seen.
Watch above, via MSNBC.
[featured image via screengrab]
Follow Joe DePaolo (@joe_depaolo) on Twitter
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Fmr. Air Force Secretary: Trump Needs to 'Tone Back the Testosterone' - Mediaite
Lipocine Announces FDA Acknowledgement of TLANDO (LPCN 1021) NDA Resubmission; PDUFA Goal Date … – GlobeNewswire (press release)
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SALT LAKE CITY, Aug. 14, 2017 (GLOBE NEWSWIRE) -- Lipocine Inc. (NASDAQ:LPCN), a specialty pharmaceutical company, today announced that the U.S. Food & Drug Administration (FDA) has acknowledged receipt of the Companys New Drug Application (NDA) resubmission for TLANDO, its oral testosterone product candidate for testosterone replacement therapy (TRT) in adult males for conditions associated with a deficiency of endogenous testosterone, also known as hypogonadism. The FDA has deemed the resubmission a complete response to its June 2016 Complete Response Letter (CRL) that requested additional information related to the dosing algorithm for the proposed label. The FDA has assigned a new Prescription Drug User Fee Act (PDUFA) goal date of February 8, 2018. The TLANDO NDA is based on the results of the Dosing Validation (DV) study. The DV study confirmed the efficacy of TLANDO with a fixed dose regimen without need for dose adjustment. TLANDO was well tolerated upon 52week exposure with no reports of drug related Serious Adverse Events (SAEs).
The FDA's acceptance of the TLANDO NDA resubmission brings us one step closer to providing an innovative oral testosterone replacement treatment option to patients. We believe TLANDO addresses a significant unmet medical need for men with hypogonadism," said Dr. Mahesh Patel, Chairman, President and Chief Executive Officer of Lipocine.
About Lipocine
Lipocine Inc. is a specialty pharmaceutical company developing innovative pharmaceutical products for use in men's and women's health using its proprietary drug delivery technologies. Lipocines clinical development pipeline includes three development programs TLANDO, LPCN 1111 and LPCN 1107. TLANDO, a novel oral prodrug of testosterone containing testosterone undecanoate, is designed to help restore normal testosterone levels in hypogonadal men. TLANDOwas well tolerated and met the primary efficacy end-points in Phase 3 testing with twice daily dosing and is currently under FDA review. LPCN 1111, a novel oral prodrug of testosterone, originated and is being developed by Lipocine as a next-generation oral testosterone product with potential for once-daily dosing and is currently in Phase 2 testing. LPCN 1107 is potentially the first oral hydroxyprogesterone caproate product candidate indicated for the prevention of recurrent preterm birth and has been granted orphan drug designation by the FDA. An End of Phase 2 meeting with the FDA has been completed. For more information, please visit http://www.lipocine.com.
Forward-Looking Statements
This release contains forward looking statements that are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995 and include statements that are not historical facts regarding Lipocines product candidates and related clinical trials and the FDA review process relating to its product candidates, our belief that we have addressed the CRL deficiency, the expected timing of the FDA review process related to our resubmitted NDA, the path to approvability by the FDA of Lipocines development programs, the potential uses and benefits of our product candidates, and our product development efforts. Investors are cautioned that all such forward-looking statements involve risks and uncertainties, including, without limitation, the risks that the FDA will not approve any of our products, risks related to our products, expected product benefits not being realized, clinical and regulatory expectations and plans not being realized, new regulatory developments and requirements, risks related to the FDA approval process including that the FDA will determine there are deficiencies in our resubmitted NDA, risks related to the possibility of an advisory committee meeting related to TLANDO, the receipt of regulatory approvals, the results and timing of clinical trials, patient acceptance of Lipocines products, the manufacturing and commercialization of Lipocines products, and other risks detailed in Lipocines filings with the SEC, including, without limitation, its Form 10-K and other reports on Forms 8-K and 10-Q, all of which can be obtained on the SEC website at http://www.sec.gov. Lipocine assumes no obligation to update or revise publicly any forward-looking statements contained in this release, except as required by law.
Testosterone and sexual function. – UroToday – UroToday
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Testosterone therapy has been advocated in the treatment of symptoms that may represent normal aging. We briefly review randomized clinical trials on the effects of testosterone therapy on sexual function.
About half of clinical trials showed no benefit of testosterone therapy on any aspect of sexual function. In those studies showing a benefit on some aspect of sexual function, most sexual function domains were not improved. Testosterone therapy has been disappointing in the treatment of erectile dysfunction. Potential risks of therapy include an increase in thromboembolic and other cardiovascular diseases.
The limited and inconsistent benefits of testosterone therapy for sexual function argue against use of this therapy in aging men, including those with 'low testosterone'.
Current opinion in urology. 2017 Aug 08 [Epub ahead of print]
Adriane Fugh-Berman, Anthony R Scialli
aDepartment of Pharmacology and Physiology, Georgetown University Medical Center bDepartment of Obstetrics and Gynecology, George Washington University School of Medicine, and Scialli Consulting LLC, Washington, District of Columbia, USA.
PubMed http://www.ncbi.nlm.nih.gov/pubmed/28795961
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Testosterone and sexual function. - UroToday - UroToday
Caster Semenya shrugs off ‘nonsense’ over gender tests and testosterone levels – Express.co.uk
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Semenya will take to the track for her two-lap final at 8.10pm tonight with a two-year unbeaten record to defend.
She is the reigning Olympic champion and has won gold (2009) and silver (2011) in the world final before.
The South African already has a medal from these championships after snatching bronze in the 1500m and is looking to win back her world title.
However, the 26-year-old is a near-constant source of controversy due to her hyperandrogenism, a condition that gives her naturally higher levels of testosterone.
She has previously been forced by the IAAF to take hormone-reducing drugs to be allowed to compete before the Court of Arbitration for Sport (CAS) overturned the ruling.
The debate rages on with British athlete Lynsey Sharp calling for the authoritities to sort it out.
But Semenya appears unflustered by the speculation that follows her almost everywhere she goes.
"I've no time for nonsense. Medication or no medication, Semenya said.
"For me, it's their own decisions.
"I really don't have time for nonsense.
"Those are the things, the issues, that I don't focus on.
It's not my business. It's their business.
"Those are the writings that I've being seeing since 2009.
"Sometimes, you get annoyed or you get bored.
"For me, it's the past. Whoever deals with it, it's their business, not mine.
"I'm not even bothered.
"I'm the kind of person who doesn't really focus on more negativity.
Im a positive person and I look at things in a positive way.
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Caster Semenya shrugs off 'nonsense' over gender tests and testosterone levels - Express.co.uk
Does testosterone optimization cause prostate cancer? – Meridian Star
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Testosterone optimization for health in men and women has become popular as well as a hot-button topic over the last 5-10 years. It has become an important factor in hormone optimization but it comes with baggage. There are rumors of benefits as well as risks. I have a heart for optimal health so I've been studying this stuff for years. Also, being a urologist, my specialty has become the leader in hormone optimization, particularly in men. If you want to skip the rest of this article, here's the take away: a normal testosterone is better for your health than a low testosterone - for guys or gals (and they both have different normal levels). And, specific to this article, all studies to date show that testosterone optimization does not increase a mans risk for prostate cancer ... I still want you to keep reading, though!
Testosterone replacement has been around, actually, for quite a while since the 1940s but only recently has it become popular. My first brush with it was when I was a resident (i.e. urologist-in-training) at the University of Virginia. We ran what we called "resident clinic" (don't worry, real doctors backed us up) I pulled a chart out of the door to find a new patient referred by another urologist from two hours south of Charlottesville for "elevated PSA on testosterone replacement." I just blankly stared at the chart. I had no idea what that meant or what I was supposed to do. Getting the background story from the patient, he was on testosterone replacement and had been for several years and now had a PSA (a screening test for prostate cancer) above the normal range. His urologist wasn't sure what to do, so here he was.
I promptly asked my boss (a real urologist not just one in training) what to do. He asked me, "Does testosterone optimization increase his risk for prostate cancer?" Again, blank stare from me. He just smirked but never answered his own question for me. We ended up performing a prostate biopsy and, lo and behold, the guy didn't have prostate cancer. So then the next question was, "Should he stop his testosterone optimization?"
The answers to those questions came months later. We had a visiting professor by the name of Abe Morgantaler. Turns out he was an expert on this testosterone stuff. He showed study after study showing no relationship between any increased risk of prostate cancer and testosterone optimization. Several studies have even shown the opposite that the lower the testosterone level, the higher the chance of having a prostate biopsy showing prostate cancer. On the other end of things, no studies, I repeat none, show an increased risk of getting prostate cancer with an optimization in testosterone levels. So, the short answer on prostate cancer and testosterone optimization is that it doesn't appear to have any relationship in other words, replacing testosterone to a normal level does not appear to increase your risk of developing prostate cancer.
So lets take it to the next level. What if youve had prostate cancer, your PSA level is negligible but you feel miserable because your testosterone level is low. Can you have your level optimized? Lets ask another way. Consider this scenario: Lets say you and your twin brother both get prostate cancer and have it treated. Both of you have negligible PSA levels afterward. Your brothers testosterone level is in the normal range and he feels fine but your level is low and youre tired all the time and moody. You go to your doctor who says you cant have testosterone levels optimized because youve had prostate cancer. But, wait a second, your brothers levels are fine. Does it put him at increased risk for recurrence? All studies point to "no." So, again, I ask, why cant your levels be normal too? Good question. And one you should ask a healthcare provider who specializes in this.
Prostate cancer risk is just one factor in testosterone optimization. Its complicated and, even as health care providers, were still learning. Turns out a normal testosterone has many benefits and very little, if any, risks. That said, guy or girl, you need to see a healthcare provider who specializes in hormones to manage them. They better understand appropriate levels to optimize benefits and minimize risks.
Testosterone optimization can help improve fatigue (i.e. energy), mood, muscle strength, sex drive and (in men) erections. It also does several other things you can't see like improve heart health, better control diabetes, lower cholesterol, improve bone strength and lower risk for dementia. It's no holy grail but it does kill (or severely injure) at least 10 birds with 1 stone.
Dr. Thomas is a board-certified physician who operates Complete Health Integrative Wellness Clinic and Thomas Urology Clinic in Starkville, Mississippi.
This newspaper column is for informational purposes only and is, under no circumstances, intended to constitute medical advice or to create or continue a physician-patient relationship. If you have a medical emergency, you should immediately seek care from your nearest emergency room, and if you have specific health questions, you should consult your own physician.
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Does testosterone optimization cause prostate cancer? - Meridian Star
‘Intersex’ athletes to learn if they will be forced to take drugs to … – Telegraph.co.uk
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Next month the CAS is expected to rule on new evidence presented by the IAAF showing that high testosterone levels could shave around 2.5 seconds of an athletes time. There is typically less than two seconds between runners in 800m heats.
However sports science experts believe the court will refuse to take action for fear of opening themselves up to claims over other naturally occurring advantages, and accusations of sexism.
John Brewer, Professor of Applied Sports Science at Queen Mary University in Twickenham, said: There is a reason that testosterone is a banned substance, it has an anaerobic affect and increases muscle strength and power, so someone with more of it is likely to have more speed. And thats clearly an advantage. Its not a level playing field.
But what can you do about it? Do you ban them? Do you have a cut off point? Do you have a separate category? The problem is there will always be athletes who are at the top of a range of physiological values whether it is oxygen uptake, or capillary density, or the ability tolerate high levels of lactic acid.
Do you ban all Kenyan athletes because they train at high altitude and so can use oxygen more efficiently? Testosterone levels is just one of many variables that impact performance. And it can work both ways. Someone with more testosterone generally gains more muscle mass and weighs more, so it can be like running with two extra bags of sugar.
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'Intersex' athletes to learn if they will be forced to take drugs to ... - Telegraph.co.uk
Phenibut high – Nolvadex raise testosterone levels – Bournville Village
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Phenibut high - Nolvadex raise testosterone levels - Bournville Village