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Global Testosterone Booster Market statistics

The Testosterone Booster market research report study recently presented by AMR provides comprehensive knowledge on the development activities by Global industry players, growth possibilities or opportunities and market sizing for Testosterone Booster along with analysis by key segments, leading and emerging players, and their presence geographies.

This research study has 131 pages, it covers the complete market overview of various profiled players and their development history, on-going development strategies along with the current situation.

The report forecast global Testosterone Booster market to grow to reach xxx Million USD in 2020 with a CAGR of xx% during the period 2020-2025.

The research benefits in recognizing and following arising players in the market and their portfolios, to enhance decision-making abilities and helps to create effective counter-strategies to gain a competing advantage. Some of the players profiled/ part of study coverage are Testofuel, GNC, TestoTEK, Prime Male, TEK Naturals, TestoGen, Prime Male, Nugenix, Monster T, TestoRush.

Get free sample: https://www.amplemarketreports.com/sample-request/global-testosterone-booster-market-1287155.html

AMRs research team has examined complete data across the globe comprising 20+ countries with a comprehensive data plan spread from 2013 to 2026 and approximately 12+ regional indicators complemented with 20+ company level coverage.

The study is organized utilizing data and knowledge sourced of various primary and secondary sources, proprietary databases, company/university websites, regulators, conferences, SEC filings, investor presentations and featured press releases from company sites and industry-specific third party sources.

Know more about focused companies, countries before buy at: https://www.amplemarketreports.com/enquiry-before-buy/global-testosterone-booster-market-1287155.html

Characteristics of the Table of Content:

The comprehensive study presented by considering all the important aspects and sections. Some of these were

Testosterone Booster MARKET RESEARCH SCOPE OBJECTIVES, TARGET AND KEY FINDINGS

Preferably, that approaching major uptrend failed to arrive on schedule, but the Testosterone Booster market raised without posting any drops and surely witnesses zeniths in years to come.

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Teenagers, Adults segment interpreted and sized in this research report by application/end-users reveals the inherent growth and several shifts for the period 2014 to 2026.

The changing dynamics supporting the growth perform it perilous for manufacturers in this extent to keep up-to-date with the changing pace of the market. Find out which segment is doing great and will return in strong earnings adding the significant drive to overall growth.

Furthermore, the research contributes an in-depth overview of regional level break-up categorized as likely leading growth rate territory, countries with the highest market share in past and current scenario. Some of the geographical break-up incorporated in the study are Asia-Pacific[China, Southeast Asia, India, Japan, Korea, Oceania], Europe[Germany, UK, France, Italy, Russia, Spain, Netherlands, Turkey, Switzerland], North America[United States, Canada, Mexico], Middle East & Africa[GCC, North Africa, South Africa], South America[Brazil, Argentina, Columbia, Chile, Peru].

In the Type segment by Component, D Aspartic Acid, Vitamin D3, Other, by Source, Mucuna Pruriens, Ginseng, Oyster Extract, Fenugreek, Stinging Nettle included for segmenting Testosterone Booster market by type.

The industry is performing well and few emerging business institutions are in their peak as per growth rate and their existence with major players of Testosterone Booster market whereas conflict between 2 Global economies continues in 2020.

Testofuel, GNC, TestoTEK, Prime Male, TEK Naturals, TestoGen, Prime Male, Nugenix, Monster T, TestoRush major key players included in this research along with their sales and revenue data show how they are performing well?

Find out more about this report at: https://www.amplemarketreports.com/report/global-testosterone-booster-market-1287155.html

Thanks for reading this article, you can also get individual chapter wise section or region wise report versions like North America, Western / Eastern Europe or Southeast Asia.

With the given market data, Research on Global Markets offers customizations according to specific needs. Write to AMR at [emailprotected], or connect via +1-530-868-6979

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Testosterone Booster Market 2020-2024:Expected to witness the fastest growth during the forecast period with Prominent Key Players Testofuel , GNC ,...

Pedophile Josie Smith is to be freed from jail after having gender reassignment treatment, which lowered her testosterone levels and the chances of her re-offending. She is currently at a residential treatment facility in Sioux City, right

A pedophile who sexually abused 15 children including a one year-old baby is to be freed from jail after transitioning to become a woman.

Josie Smith, 23, is set to be let out four years after her conviction thanks to hormone treatment which lowered her testosterone levels.

She was sentenced before she began the hormone treatment, and was originally ordered to stay behind bars indefinitely on the basis that she had the sex drive of a man.

But lowering Smiths testosterone has also diminished her sex drive, and thus dramatically decreased the risk of her re-offending, according to officials.

She has been receiving the treatment for the last two years as she prepares to potentially undergo gender reassignment surgery, the Storm Lake Times reported.

Smith was jailed in December 2015 under her old name Joseph after being convicted of molesting a student.

A pre-sentence report said she had abused up to 15 youngsters aged between one and 13, and recommended a lengthy spell behind bars.

Explaining the reason why Smith will now be freed, Iowa Attorney General spokesman Lynn Hicks said: We dont believe we have evidence sufficient to prove Josie Smith has a significant chance of re-offending.

Hicks said the Iowa Attorney Generals office has never dealt with a case like Smiths

Smith was transferred to the Sioux City Residential Treatment Facility last Saturday as she gradually prepares for her release.

Officials have yet to say when she will leave custody for good.

Hicks added: We dont believe we have evidence sufficient to prove Josie Smith has a significant chance of re-offending.

Shell be subject to supervision for the rest of her life.

A pre-sentence report prepared in 2015 found the likelihood of Smith offending pre-transition exceeded 20%.

This was based on the fact that her victims were both male and female, her being under 25 years old, and never having had a long-term relationship.

Smith was herself molested while growing up in Louisiana, with that abuse beginning when she was aged just seven.

Forensic psychologist Dr Tracy Rogers told the Des Moines Register that laws require prosecutors to prove a sex offender has a chance of of re-offending greater than 51% for the rest of his life.

That percentage is considerably lowered when an offender has treatment to lower testosterone levels, like Smith has.

Originally posted here:
Pedophile who molested baby freed from jail after transitioning to become female - Metro.co.uk

What does it mean to be a man? More specifically, what does it mean to be a man in the U.S? In Spain? Among Native American communities? There are so many different factors both cultural and otherwise that are embedded in this question. But what does masculinity look like around the world and what similarities present themselves? And, more importantly, what does how we talk about it and attempt to explain away behaviors using biology or speak of men in terms of Alpha and Beta say about us?

In, Are Men Animals? How Modern Masculinity Sells Men Short, anthropologist Matthew Gutmann, a professor of anthropology at Brown University who has spent 30 years exploring notions of masculinity across the United States, Latin America, and China, describes how the ways society can speak about men and explain away their behavior through bad science such as when, during the Brett Kavanaugh hearings, testosterone was associated with negative male behavior limits mens emotional expression and denies them agency and accountability over their actions. For Gutmann, using such terms and phrases as testosterone, boys being boys, and just being a guy is tantamount to when doctors 30 or 40 years ago would say that women cant be leaders because their periods made them too unpredictable. In other words, he says, such talk paints men into a corner.

Fatherly spoke to Gutmann about why explaining away masculinity with biology doesnt help anyone, why the term alpha male means nothing, and why men comparing themselves to wolves and chimpanzees is not only severely limiting its also extremely misguided.

Youve spent 30 years looking at masculinity around the world. What were some things you really wanted to address in this book? What was important to you about dispelling myths about masculinity?

How stressful do you find days when your kids can't go outside?

Not stressful at all. We make the best of it

Sometimes they are, sometimes they arent. Depends on the circumstance.

Extremely stressful. Its hard to entertain them

Thanks for the feedback!

There is a widespread tendency to say, well, boys will be boys. So in the Brett Kavanaugh Supreme Court justice hearings, it was remarkable how many times I read the word testosterone associated with male teenage behavior. As if other boys didnt have testosterone as teenagers; as if testosterone surging through your blood, if youre a teenage boy, accounts for sexual assault against women. That, to me, is very disturbing, when we assume that teenage boys almost cant help themselves from assaulting.

Is there an extent to which being a masculine man is biological, or is more of a cultural definition?

I think that you find as much variation worldwide and historically, as you can imagine. There isnt one way of being a man in any society. But certainly, science and biology have come to be very significant and influential ways of framing or thinking in general. Its not just about men and masculinity.

What do you mean?

One-hundred years ago, youd find scientists running all over the place saying, Women cant be leaders. There have never been women leaders in parliament, in congress, except for a few queens. Thats because of biology. Dont you think if women could be political leaders, we would have seen some by now?

That was a plausible argument. So its not a new way of looking at the world, to explain it through so-called science. But its bad science. And I think that its been too long unexamined with respect to men and masculinity today. The fact is, its very easy for people to fall into thinking, This is the way men are, and this is the way women are. But thats not true anywhere.

Lets talk about definitions of masculinity. Is it defined differently in the Western world than in other cultures?

It varies a lot within the United States, too, if you really get into it. Among Native American peoples in the plains, a long tradition of whats sometimes called third-gender, berdache, two-spirit people, these kinds of things. And thats in the United States. But thats not the dominant way of thinking about men and masculinity, that you have people who were born male but would assume female roles and might have sex with other biological men and that kind of thing, but would not consider themselves gay. But you dont hear about that stuff, usually, because it doesnt fit into dominant ways of thinking.

In Southern Spain, theres been a long stereotype that if a wife wants to have sex all the time with her husband, shes trying to kill him off, because men are only born with so much sperm and when it runs out, they die. Thats exactly the flip side of what you would hear about in terms of men and sexual predation.

One-hundred years ago, in many farming communities in much of the world, where children werent going to school, men were taking their kids to the fields, particularly their young boys, but also, their daughters. Theyre going to spend a lot more time with their children. This is a pattern that is impossible in the city, if youre driving a bus or working in a factory, you cant take your kid to work.

When did the dominant way of thinking about masculinity being strong and silent, having sexual conquests, etc. became really, really mainstream?

I think its always been around to some extent. But one of the things I would emphasize is that there may be dominant ideas but theres always been pushback and a lot of confusion, debate, and argument over what it means to be a man. One-hundred and fifty years ago, people were arguing strenuously that women should vote; women should be leaders; men are not the only ones who can do this; that men can be great fathers. But that wasnt dominant. So you find people pushing back.

The fact that young men in the United States, and 70 other countries in the world, when men turn 18 or so, they have to register for the draft or a possible draft, and young women do not have to do that, why do we go along with that, unquestioningly?

Why is that the way it is? Soldiers are not carrying spears or shields. Its not an issue of upper body strength. Its because people believe theres something inherently violent, or potentially violent, about men that makes them more adaptable for war. And theres no evidence thats true.

There are violent men, but most men are not violent. You can even say most people who kill are men thats absolutely true and vital but most men are not killers. And thats just as important. And if its biological, you would expect to find all men this and all men that and you dont. Its cultural.

One thing that really intrigued me about your book was how you wrote about such species as chimpanzees and wolves. Is there an extent to which weve transposed human ideals of masculinity on to pack animals?

Right.

Can you walk that out for me?

When I was young, I would watch nature shows on TV: Animal Planet, Discovery Channel. When I would hear about the male zebra, or the male orangutan, I would pay more attention, because thats the way males of those species behave. And, it began to sink in, that men do this and women do that. The problem is that theres variation among male zebras. Theres variation among male orangutans. But even that pales in comparison among variation among human males.

What do you mean?

If you are a mallard duck, youre going to behave within a fairly limited repertoire of behavior. If youre a human male, the possibilities are not endless, but they are vast. Thats the big difference. Its not that it doesnt take a male and a female, in terms of gametes, to make offspring, and that that isnt similar across animal species. It is. Its not like there are no similarities.

But we trick ourselves into thinking that we have such narrow kinds of possibilities, as humans, if we constantly are comparing ourselves to the chimpanzees, or gorillas or other primates. But its very easy to do it. In biology textbooks, in classes at universities, youre taught that females are choosy across species, and males want to have sex with all the females they can to procreate and spread their seed.

Right. And men need to do that too, or so the myth goes.

If you think about it for half a second, its nonsense. Human males are incredibly choosy about with whom they have sex, and most people in the 21st century, when they have sex, theyre not looking to have babies. Theyre not looking to spread their seed. Thats not the point.

I read an article recently that said that theres no real concept of an alpha wolf in the wild, but it exists in captivity. What does it mean that men have totally taken on this identity, as being the alpha or the alpha wolf or alpha male when it doesnt even really exist in nature? That thats the gold standard of being a human man being an alpha?

I think again, ultimately, it excuses men being in charge. Its saying that theres something biological: that men have a need to be in charge, and females have a need for men to be in charge, and the successful men are the alphas. Its a problem on so many different levels.

One, its actually healthier, in many species, to be a beta male. You dont have nearly the same levels of stress. It can be measured through cortisol levels. Beta males among chimps are a lot healthier, in many respects. They dont have everyone attacking them. There are even some studies that say that they have more sex.

But beyond that, whats curious is that you have other species wolves, bonobos (the so-called pygmy chimpanzees) where you have alpha female led troops to a much greater extent. Females have much more of a say in terms of who gets what, and what happens when, and all of that.

But we dont generally, on nature shows, care nearly as much about those mammals, because they dont coincide with the idea that men are in charge and should be.

Just even to the extent that you say that beta males are often happier and healthier, I laughed, because it reminds me a lot of human men who posture and exhibit idealized masculinity. They often have shorter lifespans, are more stressed out, and have all these negative health outcomes. So its like, what are we doing?

I think the language we use today has been too long unexamined about men. And thats what Im trying to do in the book, is call attention. Not because its exactly the same with respect to men and women when you use this language, but its also, potentially, more dangerous if we assume that, because men have certain kinds of hormones in higher levels than women, then anything happens automatically.

The fact is that women, for ovulation, need testosterone. But we dont hear about that very much. We hear about levels of testosterone as if they correlated with anything in particular [in terms of male aggression] and it turns out they dont.

Right. Women are too hormonal to be leaders. Men have too much testosterone to not be violent.

Hubert Humphrey, a presidential candidate, had a doctor who became quite famous. At one point he said, You cannot have women leaders in charge of war, because theyre too unpredictable, biologically, and theyre likely to do anything crazy at any time. There were people who pushed back hard against that idea, but it was much more plausible to a lot more people.

The fact is, whatever you think about Trump, tens of millions of women voted for him, and somehow, that needs to be explained.

Were they all just holding their noses about what they thought about his assaults on women and his desire to assault more women? Or, did they say, Like it or not, thats just the way guys are! Hes just a guys guy! And more guys would do it if they thought they could get away with it!

That, to me, is the most dangerous kind of thinking around. Its not just men who have that thinking. Its women, too.

Its funny. The sexist assumptions about women that they cant be leaders because of their hormones are used to help limit their engagement with politics or their roles in leadership. And then, on the other hand, the really sexist misguided assumptions about men that their testosterone makes them monsters or insatiable sex addicts or whatever serves to give them a pass to do whatever. Its like the same dynamic, but moving in opposite directions.

I agree. Ive given talks on this subject and Ive had women tell me, I agree a lot with what youre saying, but the fact is that men are more aggressive than women. And I think we need to really, as the academics would say, unpack that idea. What do we mean when we say men are more aggressive? Ill start pointing in the room. Is this guy more aggressive than that woman? What about that guy over there? And all of the sudden, the argument falls apart, because if youre actually talking about real people, it doesnt necessarily apply at all. We all know that. Not all men are more aggressive than all women. Its a ridiculous thing to say. But the phrase, men are more aggressive than women, if you dont challenge it, is very easy to make and people nod their head and say, Yeah, thats just the way it is.

Men want to have sex more than women. Yeah, right.

25 years ago, people told me that men are more visually stimulated than women and thats why men like porn and women dont. I didnt believe it was true, but I had no argument. Then, the internet became widely available and women started watching porn in the privacy of their own homes. The number of women watching porn went up dramatically when there was no longer the issue of having to do it so publicly.

This biological fact of visual stimulation just disappeared as an argument, and you dont find that anymore to nearly the same extent. Similarly, its very easy to make these general statements, but we need to look more carefully, because theres tremendous variation. Its because of that variation that theres hope.

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How the Myth of the Alpha Male Has Hijacked Modern Masculinity - Fatherly

NEW ORLEANS Growing older is part of life, but it doesn't mean you have to feel old.

Science is catching up to what we are lacking as we age.

And that's helping some middle-aged people feel like they are in their thirties. They changed their health and dropped weight because of hormone replacement therapy. They say taking the step was life-changing.

"I was extremely lethargic and depressed because I was tired all the time," said Alison Beebe, 50.

"I had no energy. I was overweight. I didn't think it would ever change. I battled this for years and years," said Michael Hebert, 59.

Alison and Michael never thought they would feel this good and be this healthy.

"And I went from not exercising and sitting at home on my couch and eating chips, to running half marathons and at the gym all the time. I've lost 30 pounds since that, and feel like I'm in my early 30s," said Beebe.

"I never believedthat I could sit here today and tell you that I'mat the same weight that I played at Arch Bishop Rummel in the mid-70s," said Hebert.

They turned to Dr. Pam Egan in Covington, who specializes in hormone replacement therapy, metabolism and nutrition. She says hormones and proper nutrition keep our cells young and healthy, without it, they die and disease sets in.

"When the body is nutritionally and hormonally sound it's like you give yourselves the proper tools for the body to heal itself," explained Dr. Pam Egan, a Doctor of Nursing Practice at Egan Wellness and Med Spa in Covington.

Men and Women lose hormones with age, or for women through a hysterectomy, even when you keep your ovaries. Studies show estrogen, progesterone and testosterone given in lower, correctly balanced doses, along with the right supplements, are safe.

"It has not been shown to increase breast cancer, blood clots, or heart disease," said Dr. Egan.

Alison says she now feels her best for her four children. Her body fat isdown from 50 to 15 percent. Michael says seeing his wife Kim at 60 feel so good from hormones, is what encouraged him to go to Dr. Egan. He's down 73 pounds and his blood work went from showingdangerous health signsto perfect.

"My dad died at 60 of a heart attack. If it helps one person, it's worth sitting here talking about it," Hebert said about sharing his health journey.

Dr. Egan says alcohol, pesticides on foods, heated plastic, and cleaning solvents, mimic the wrong forms of hormones in the body, leading to breast and other cancers. Click here for Dr. Egan's website.

Dr. Egan's book: "Managing Menopause with Bio-Identical Hormones"

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Hormone replacement is helping patients stay healthy later in life. - WWLTV.com

Olly Mann and The Week delve behind the headlines and debate what really matters from the past seven days.

In this weeks episode, we discuss:

Testosterone levels have been in decline for some time, and a long-term study published this week in the Journal of Sexual Medicine reveals the extent of the phenomenon: men aged between 15 and 39 now have 25% less testosterone than men of the same age in 1999 - a huge drop in just 20 years. Many theories have been put forward, including diet, lifestyle, underwear trends and even social attitudes towards masculinity. But why testosterone levels are dropping - and what the end result might be - remains a mystery.

An employment tribunal has ruled that ethical veganism is a philosophical belief akin to a religion that is protected by law against discrimination. But could the verdict come back to bite the growing movement? And which other beliefs are or should be safeguarded by our courts?

East Africa is in the grip of the most severe swarms of locusts in over 70 years, threatening food supply to millions across Somalia, Kenya and Ethiopia. With climate change fuelling their breeding and governments asleep at the wheel - are we all doomed to face more plagues in the future?

You can subscribe to The Week Unwrapped on theGlobal Player,Apple podcasts,SoundCloudor wherever you get your podcasts. It is produced by Sarah Myles and the music is by Tom Mawby.

Excerpt from:
The Week Unwrapped podcast: Testosterone, vegans and locusts - The Week UK

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Newswise SALT LAKE CITY In the first-ever genome-scale analysis of the puberty process in humans, researchers at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) outline distinct and critical changes to stem cells in males during adolescence. They further outline how testosterone, and the cells that produce testosterone, impact stem cells in male reproductive organs. The researchers believe this study adds dramatically to a foundation of knowledge that may yield insights into critical areas of human health, including infertility and cellular changes that lead to cancer and other diseases.

The study, published today in the journal Cell Stem Cell, was led by Bradley Cairns, PhD, cancer researcher at HCI and professor and chair of oncological sciences at the U of U, in collaboration with colleagues Jingtao Guo, PhD, a postdoctoral fellow in the Cairns lab at HCI, James Hotaling, MD, associate professor of surgery at the U of U, and Anne Goriely, PhD, associate professor of human genetics at the University of Oxford.

Puberty spurs numerous developmental changes in humans and other mammals. Hallmarks of puberty include physical characteristics easily visible to the naked eye, like rapid growth. These physical and hormonal changes signal the process of a maturing body preparing for reproductive years.

In the testis, the male reproductive organ that makes and stores sperm and produces testosterone, puberty introduces monumental changes at a cellular and physiological level. Thanks to new genomic technologies, researchers are able to examine the expression of thousands of genes in each individual cell in an entire organ, providing unprecedented insights into cellular behavior during puberty.

Several types of cells within the testis regulate reproductive health. Like the human body that changes along the path from infancy to adulthood, these cells undergo major changes as the body matures. These cells include spermatogonial stem cells that ultimately generate sperm production, and niche cells that help form parts of the testis, such as the seminiferous tubule, a tube-like structure within which sperm is formed. In this study, researchers characterized how, just prior to puberty, spermatogonial stem cells first expand significantly in number. These stem cells progress toward meiosis, a special type of cell division that splits the number of chromosomes from the parent cell in half, and also separates the male X and Y sex chromosomes to create cells that, after fertilization of eggs and considerable subsequent development, will ultimately result in either male (Y-containing) or female (X-containing) children. Late in puberty, these stem cells commit to creating mature sperm, which includes a tail piece for motility. The researchers showed how two of the cells that form the stem cell niche and chaperone this processthe myoid cells and Leydig cellsderive from a common precursor, and mature during early puberty.

A major novel insight of this study was the first-ever genomic analysis of the testis of adult transfemales (individuals assigned male at birth, but who self-identify as female). For these individuals, gender confirmation surgery is preceded by hormone therapy that induces long-term testosterone suppression, enabling the examination of testis lacking testosterone. By using samples donated after surgery, researchers uncovered critical insights into the role of testosterone in maintaining testis development. Genomic analysis of the cells from the testis of transfemales showed that stem cells and other cells revert to earlier states of development when compared to samples from male adolescents. Thus, Cairns and his colleagues identified that testosterone is critical to maintaining the mature state of the testis: if testosterone is no longer present, the testis reverts to an earlier developmental state.

The major changes that occur in humans during puberty give rise to numerous functions in normal development, like reproductive health and fertility. But, when these processes go awry, confounding challenges can result. Infertility is a relatively common health issue. About 50 percent of the time, the underlying cause is attributed to the male reproductive functions, which often include errors that occur during puberty. The team hopes these insights into how cells develop will help yield insights into what happens when developmental issues during puberty cause changes that result in infertility.

The study also informs understanding of cancer and other diseases that arise due to errors in cellular processes. The majority of the time, testicular cancers arise when stem cells in the testis are misregulated, said Cairns. We want to understand how these changes can cause testicular tumors; however, we need to know what should normally happen before we can identify ways to prevent or more effectively treat these cancers.

In juveniles, cancers and reproductive health intersect via a medical process called oncofertility; that is, the study of how to retain fertility in adolescent and young adult cancer patients whose reproductive health and fertility may be impacted by their cancer, or as a result of side effects of cancer treatment. Some chemotherapies can result in young men with cancer not being able to have childrenthe chemotherapy can cause changes to their stem cells, said Cairns. My hope and expectation is that our research will provide a foundation for creating options to support the reproductive health of young men affected by cancer through a better understanding of how these stem cells survive, are supported, and develop.

This research was supported by the National Cancer Institute grant P30 CA042014, the Howard Hughes Medical Institute, and Huntsman Cancer Foundation.

###

About Huntsman Cancer Institute:

Huntsman Cancer Institute(HCI) at theUniversity of Utahis the official cancer center of Utah. The cancer campus includes a state-of-the-art cancer specialty hospital as well as two buildings dedicated to cancer research. HCI treats patients with all forms of cancer and is recognized among the best performing cancer hospitals in the country by U.S. News and World Report. As the onlyNational Cancer Institute (NCI)-Designated Comprehensive Cancer Centerin the Mountain West, HCI serves the largest geographic region in the country, drawing patients from Utah, Nevada, Idaho, Wyoming, and Montana. More genes for inherited cancers have been discovered at HCI than at any other cancer center in the world, including genes responsible for hereditary breast, ovarian, colon, head, and neck cancers, along with melanoma. HCI manages theUtah Population Database, the largest genetic database in the world, with information on more than 11 million people linked to genealogies, health records, and vital statistics. HCI was founded byJon M. and Karen Huntsman.

SEE ORIGINAL STUDY

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First-Ever Genomic Study of Puberty Yields Insights into Development, Cancer, and Infertility - Newswise

How men can help women advance in the workplace

Businesses thrive when both genders are represented at the top of their companies, according to studies. But in order for women to achieve parity, men need to help women succeed in their careers, according to Forbes contributor and leadership professor Susan Madsen. She recommended that men fight gender discrimination in the workplace, recognize womens contributions in public and private settings, provide honest feedback and refine human resources processes and procedures.

States weigh measures to stop transgender athletes from competing in womens sports

In the past few weeks, at least five states have drafted legislation to regulate transgender participation in girl's and boys high school sports. Republican legislatures in New Hampshire, Washington, Georgia, Tennessee and Missouri have drafted bills primarily to bar transgendered students from playing on girls teams, citing physical unfairness. The bill in New Hampshire says that students can prove they are female by submitting proof of their female anatomy, testosterone levels and sex chromosomes.

Fired at 40, comeback at 54, how Ellen Latham built fitness giant Orange Theory

At age 40, Ellen Latham had a dream job as an exercise physiologist at a high-end spa. She appeared on TV frequently as a fitness expert. Then one day, she was fired. She was a single mom and had no idea what to do next. Fourteen years later, she became the founder of Orangetheory Fitness, a $1 billion franchise with 1,200 studios around the globe. Know Your Value interviewed Latham to learn about her drive, her comprehensive workout, and the new documentary Momentum Shift, which chronicles the rise of Orangetheory.

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Raising my sensitive child was hell. Heres how we both survived her SPD, anxiety, and ADHD

There is hope for parents who are raising special needs children and having a difficult time. Thats the message from mother Jo Lomeo-Allen, who wrote a heartrending essay about raising her daughter who has ADHD, Sensory Processing Disorder, and Generalized Anxiety Disorder. Lomeo-Allen detailed her quest for diagnoses and treatment as her daughter threw hours-long tantrums over small things, such as a Cheerio dropping on the floor. Lomeo-Allen offered hope to parents and detailed her daughters road to stability.

Michelle Williams tells women at Golden Globes to vote in their self-interest, like men

Actress Michelle Williams didnt miss a chance to send a message during her Golden Globes acceptance speech Sunday. After accepting the award for Best Performance by an Actress in a Limited Series or Television Movie for her role in Fosse/Verdon, Williams encouraged women to vote in their own self-interest. So women, 18 to 118, when it is time to vote, please do so in your own self interest," Williams said. "It's what men have been doing for years which is why the world looks so much like them. Don't forget we are the largest voting body in this country. Let's make it look more like us."

How to stop stress-eating your way through the 2020 election

The upcoming election is a stress trigger for 56 percent of American adults, according to the American Psychological Association. Many of these adults overeat in order to cope with their stress. Clinical psychologists recommend that stress eaters take me time and limit their access to media. They suggest deep breathing, being social, and going for fruit instead of high-fat products.

All the celebrities who announced theyre expecting babies this year

Cameron Diaz, 47, announced the birth of her daughter Raddix on Friday. Other celebrities are following suit and announcing 2020 due dates, including actresses America Ferrera, Chloe Sevigny and Michelle Williams, according to Glamour. Others include U.S. Womens Soccer star Alex Morgan, actress Anne Hathaway, Laura Prepon from Orange is the New Black, and supermodel Petra Nmcov.

Black Britons know why Meghan Markle wants out

In the wake of Meghan Markle and Prince Harrys historic exit from the British royal family, Markle was called selfish and rogue by British press. However, writer Afua Hirsch argued that it was racism that pushed Markle and Prince Harry out of Buckingham Palace. Markle was the subject of extreme, unfair vitriol, which Hirsch believes is rooted in Britains history of class privilege, and the rising right-wing politics in the country.

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In the know: Women in the news 1/6 - 1/10 - NBC News

When a non-scientist tries to imagine a scientist, the image that often arises is one of a somewhat remote, rather idealistic genius sitting alone in their room or laboratory and somehow discovering the most amazing things without every having contact with the 'normal' world. But science is just as much a part of life as any other activity. So it's perhaps not all that surprising to learn that - just like in normal life - intuition can occasionally play a major role in scientific progress.

The importance of intuition was made very clear to Professor Samer Ezziddin and his team at the Department of Nuclear Medicine at Saarland University when they followed up on findings made during their medical research work into the treatment of patients with late-stage prostate cancer. The work centres around two receptors on the surface of the tumour. The first is known as prostate-specific membrane antigen (PSMA), a protein molecule that is very prevalent on the surface of prostate tumours. This surface receptor molecule acts as a gateway and provides a channel through which nuclear radiologists can smuggle radioactive substances into the tumour cells and thus destroy these malignant cells from the inside. The more PSMA molecules on the surface, the more radioactivity can be introduced into the cells without needing to increase the total dosage of radioactive substance being administered to the patient.

The second type of receptor is one that male sex hormones, such as testosterone, are able to dock onto. 'Prostate tumours need testosterone like a car needs petrol,' explains Professor Ezzidin. So one of the therapies used to treat prostate cancer involves blocking these receptor sites, which effectively stops the cancer from refuelling. 'One of the drugs used to block these receptors is enzalutamide and enzalutamide therapy is often very successful for a certain period of time, during which the tumour shrinks,' says Samer Ezzidin. 'But after a while - which might be several months, perhaps even two years if things go well - the drug stops working and the tumour starts to grow again.' Typically, the patient will then be taken off the expensive medication, as there would seem to be no reason to continue to administer it if it's no longer effective.

This is where the intuition of the Homburg research team comes to the fore. What may be of no use for one type of therapy (an ineffective drug) might turn out to be beneficial in another form of cancer therapy. 'We suspected, and later on we showed quite definitively, that the density of PSMA sites on the surface of the tumour cell increases when the adrogen receptor to which testosterone attaches is blocked,' says Ezzidin. The gut feeling within the research group, combined with the group's clinical observations, strongly suggested that this mechanism would still function in patients for whom the receptor-blocking drug (enzalutamide) was no longer itself therapeutically effective and was therefore no longer being prescribed.

The intuition of the medical research team proved to be spot on. 'We were able to prove that administering enzalutamide resulted in a significant increase in the PSMA density on the tumour surface, even though the drug was no longer effective in its original therapeutic sense and was no longer being prescribed for that purpose,' explains Samer Ezzidin. Despite the fact that only ten patients were involved the study, Professor Ezzidin believes that the results are compelling. 'After administering enzalutamide, we observed a significant increase in PSMA density on the tumour surface in all patients in the study. This allows us to introduce far more of the radioactive therapeutic agent into the tumour cells and thus irradiate them from the inside with irradiation paths that are down at the micrometre level,' says Ezzidin. As a result, PSMA radioligand therapy will be able to treat prostate tumours more efficiently and more selectively than has been possible in the past (see the following report for more details: https://www.eurekalert.org/pub_releases/2019-11/su-pcr112519.php).

'These findings now need to be subjected to further study and corroborated in a future research project,' explains Professor Ezzidin. 'But we wanted to publish our results as quickly as possible, as our findings may be of help to lots of patients. That's why we decided to first issue this short communication. I expect that even this small-scale study will lead to a drastic change in the therapy management regimens used when treating patients with advanced prostate cancer,' says Samer Ezzidin. And it's very likely that Professor Ezzidin's intuition will once again turn out to be right on the mark.

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Nuclear radiologists 'outsmart' prostate cancer with an apparently ineffective drug - Science Codex

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Testosterone Replacement Therapy Market Business Status, Industry Trends and Outlook 2020 to 2027 - Food & Beverage Herald

Paris, January 08, 2020, 7pm

FDA green-lights U.S. patient enrollment in masitinib Phase 3 study following IND clearance in metastatic castrate-resistant prostate cancer eligible to chemotherapy

Topline results expected to be available by end of 2020

AB Science SA (NYSE Euronext - FR0010557264 - AB) today announces that the U.S. Food and Drug Administration (FDA) has cleared the company's Investigational New Drug (IND) application to conduct its masitinib Phase 3 study (AB12003) in metastatic castrate-resistant prostate cancer (mCRPC) eligible to chemotherapy.

Study AB12003 is an international, multicenter, randomized, double blind, placebo-controlled, 2-parallel group, Phase 3 study in metastatic castrate resistant prostate cancer (mCRPC) eligible to chemotherapy. The study aims to compare the efficacy and safety of masitinib (6.0 mg/kg/day) in combination with docetaxel to placebo in combination with docetaxel. Docetaxel is combined with prednisone.

The study primary endpoint is progression free survival (PFS). A total of 468 patients are planned to be enrolled.

The target patient population consists of adult males who have progressed to develop metastatic castrate resistant prostate cancer (mCRPC) after castration treatment (i.e. reduction of available androgen/testosterone/DHT by chemical or surgical means) and are therefore eligible for chemotherapy.

An interim analysis was performed by the Independent Data Monitoring Committee (IDMC) in June 2018. Based on the rules set for the interim analysis, the recommendation from the IDMC was to continue the study in a pre-specified subgroup of patients that are identified by a biomarker. According to the statistical rule of the protocol at the interim analysis, this means that the probability of success of study AB12003 may exceed 80% in this pre-specified subgroup, assuming that the patients remaining to be enrolled behave similarly to those analyzed at the interim analysis. The subgroup of patients is expected to represent around two-thirds of the population.

AB Science expects the topline results from the trial to be available by end of 2020.

About castrate-resistant prostate cancer (CRPC)

Development of prostate cancer is often driven by male sex hormones called androgens, including testosterone. Castrate-resistant prostate cancer (CRPC) is defined by disease progression despite androgen depletion (hormone) therapy and may present as either a continuous rise in serum prostate-specific antigen (PSA) levels, the progression of pre-existing disease, and/or the appearance of new metastases. Metastatic CRPC (mCRPC) occurs when the cancer spreads to other parts of the body.

Prostate cancer is the most common cause of cancer in men, with 137.9 new cases per 100,000 men per year [1]. The estimated prevalence of people living with prostate cancer is 113 per 100,000 [2], with approximately 15% of the patients having metastatic castrate-resistant prostate cancer (mCRPC) eligible to chemotherapy [3]. As such, population with metastatic castrate-resistant prostate cancer (mCRPC) eligible to chemotherapy is around 75,000 in the EU and 50,000 in the USA.

Prostate cancer is also the second most common cause of cancer death in men, with the highest rates being in North America, Australia, and Northern and Central Europe. Although the overall 5-year survival rate for prostate cancer is very high, up to 20% of men who undergo state-of-the art treatment for prostate cancer will develop CRPC within 5 years, and at least 84% of these will have metastases at the time of CRPC diagnosis [1]. Practically all patients with metastatic disease become resistant to androgen-deprivation therapy. Median survival for those with mCRPC ranges from approximately 15 to 36 months in recent studies, and 5-year survival is only 28% [1].

References[1] Crawford ED, Petrylak D, Sartor O. Navigating the evolving therapeutic landscape in advanced prostate cancer. Urol Oncol. 2017 May;35S:S1-S13. doi: 10.1016/j.urolonc.2017.01.020. [2] Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394424. [3] Scher 2015 PLoSONE - Symptomatic mCRPC that has not been treated with or not progressed on chemotherapy

About masitinibMasitinib is a new orally administered tyrosine kinase inhibitor that targets mast cells and macrophages, important cells for immunity, through inhibiting a limited number of kinases. Based on its unique mechanism of action, masitinib can be developed in a large number of conditions in oncology, in inflammatory diseases, and in certain diseases of the central nervous system. In oncology due to its immunotherapy effect, masitinib can have an effect on survival, alone or in combination with chemotherapy. Through its activity on mast cells and microglia and consequently the inhibition of the activation of the inflammatory process, masitinib can have an effect on the symptoms associated with some inflammatory and central nervous system diseases and the degeneration of these diseases.

About AB ScienceFounded in 2001, AB Science is a pharmaceutical company specializing in the research, development and commercialization of protein kinase inhibitors (PKIs), a class of targeted proteins whose action are key in signaling pathways within cells. Our programs target only diseases with high unmet medical needs, often lethal with short term survival or rare or refractory to previous line of treatment. AB Science has developed a proprietary portfolio of molecules and the Companys lead compound, masitinib, has already been registered for veterinary medicine and is developed in human medicine in oncology, neurological diseases, and inflammatory diseases. The company is headquartered in Paris, France, and listed on Euronext Paris (ticker: AB).

Further information is available on AB Sciences website: http://www.ab-science.com.

Forward-looking Statements - AB ScienceThis press release contains forward-looking statements. These statements are not historical facts. These statements include projections and estimates as well as the assumptions on which they are based, statements based on projects, objectives, intentions and expectations regarding financial results, events, operations, future services, product development and their potential or future performance.

These forward-looking statements can often be identified by the words "expect", "anticipate", "believe", "intend", "estimate" or "plan" as well as other similar terms. While AB Science believes these forward-looking statements are reasonable, investors are cautioned that these forward-looking statements are subject to numerous risks and uncertainties that are difficult to predict and generally beyond the control of AB Science and which may imply that results and actual events significantly differ from those expressed, induced or anticipated in the forward-looking information and statements. These risks and uncertainties include the uncertainties related to product development of the Company which may not be successful or to the marketing authorizations granted by competent authorities or, more generally, any factors that may affect marketing capacity of the products developed by AB Science, as well as those developed or identified in the public documents filed by AB Science with the Autorit des Marchs Financiers (AMF), including those listed in the Chapter 4 "Risk Factors" of AB Science reference document filed with the AMF on November 22, 2016, under the number R. 16-078. AB Science disclaims any obligationor undertaking to update the forward-looking information and statements, subject to the applicable regulations, in particular articles 223-1 et seq. of the AMF General Regulations.

For additional information, please contact:

AB ScienceFinancial Communication & Media Relations investors@ab-science.com

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AB Science announces that FDA green-lights U.S. patient enrollment in masitinib Phase 3 study following IND clearance in metastatic castrate-resistant...

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