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Testosterone Replacement Therapy Market 2018: Global Industry Insights by Global Players, Regional Segmentation, Growth, Applications, Major Drivers, Value and Foreseen till 2024

The report provides both quantitative and qualitative information of global Testosterone Replacement Therapy market for period of 2018 to 2025. As per the analysis provided in the report, the global market of Testosterone Replacement Therapy is estimated to growth at a CAGR of _% during the forecast period 2018 to 2025 and is expected to rise to USD _ million/billion by the end of year 2025. In the year 2016, the global Testosterone Replacement Therapy market was valued at USD _ million/billion.

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Testosterone Replacement Therapy Market : Recent Industry Trends and Projected Industry Growth, 2019 2026 - Feed Road

The book: In the summer of 2017, white nationalists gathered in Charlottesville, Va., for The Unite the Right rally, a gathering of the so-called alt-right that would turn fatally violent, as dozens of counterprotestors were injured and one was killed in a vehicular attack by one of the neo-Nazi attendees.

Cry Havoc: Charlottesville and American Democracy Under Siege (PublicAffairs) is then- Charlottesville mayor Michael Signer 95s reflection on the rally and the governmental response to it. A lawyer and political scientist by trade, Signer reflects on the balance between supporting free speech and public order and the need for civility and understanding amid extremism.

Opening lines: What happened on the weekend of August 11-12, 2017, in Charlottesville, Virginia, was so horrific, was such a tear in the fabric of a small citys ordinary experience, that it strains ones power to describe. Hordes of white nationalists invaded the University of Virginia and then the Downtown Mall of the city, ostensibly to support the preservation of a statue of Confederate general Robert E. Lee. They clashed violently with counterprotesters along the way before a neo-Nazi terrorist drove his car into a crowd of counterprotesters, killing one young woman and injuring nineteen others.

The events were cinematic, to be sure, quickly branded into the nations consciousness by a Vice News documentary that went viral. The video showed muscular, violent men chanting Jews will not replace us as they carried torches on the fabled Grounds of the university. It showed a melee near the quaint Downtown Mall, where right-wing activists, bearing handmade shields and helmets, cracked flagpoles onto left-wing counterprotesters and sent fists flying into faces. One counterprotester used a spray can as a torch; a white protester fired a handgun toward a black counterprotester (luckily, not hitting him). Others hurled newspaper boxes. Waves of neo-Nazis, wearing swastika apparel, rolled on foot into anti-racist activists wearing Black Lives Matter shirts. People fell onto concrete and blacktop, thrashing against each other. As the violence spread like wildfire, police from both the state and the city stood by impassively.

These scenes are available to anyone who types Charlottesville into Google.

But what stays in my memory were not these broad canvases of violence and suffering. It is instead individual vignettes, which I can slow down and replay in my mind, of men and women brought to anxiety and violence by extremism.

After taking an early-morning swim at the gym on Monticello Avenue, my friend Richard, an African American man in his late fifties who grew up in segregated Charlottesville, watching a militia of neo-Nazis unload from a rented tour bus. As they adjusted their shields and helmets, holding assault rifles, Richard said, they were smiling and cheerful, like they were going to a party. Fearing for his safety, he retreated quickly back into the building from which he had come.

As neo-Nazis marched with tiki torches through Thomas Jeffersons famed Lawn at the University of Virginia, around Jeffersons Rotunda, and up to a statue of Jefferson, a group of UVA students linking arms and surrounding the statue, despite the melee unleashed on them, with pepper spray, punches, and blood.

At the rally, a man hurling a punch at a young female counterprotester as he walked by, knocking her back several feet. The untrammeled testosterone, the shocking violence, the mayhem in that blatant, unashamed act of battery.

Reviews: Charlottesville, Virginia, my hometown, is now an emblem and a microcosm of the tensions and divisions roiling our nation. Mayor Michael Signer found himself in the center of a growing brushfire that culminated in the murderous Unite the Right demonstration in August 2017. Here he tells a difficult, unsparing, but often engrossing story that illuminates just how hard it can be to face our past while also finding a healing and hopeful path forward. Anne-Marie Slaughter 80, CEO, New America

Read more here:
Mayor Michael Signer '95 Reflects on the Violence of Charlottesville - Princeton Alumni Weekly

The IOC has delayed its consultation on transgender athletes until after the Tokyo Olympics (KAZUHIRO NOGI/AFP/Getty)

The International Olympic Committee (IOC) has announced that it will wait until after the 2020 Tokyo Olympics to deliver new guidelines on transgender athletes.

The IOC is currently working on a consultation to develop a framework for transgender athletes that will protect inclusivity, safety and fairness in sport. This will be based on data and research from the scientific and human rights sectors.

It had hoped to finish the consultation ahead of this years Olympic Games, but decided to wait in order to avoid disrupting the qualifying events.

Speaking on Wednesday, the IOCs medical and scientific director, Richard Budgett, said that changing the policy so close to the event would not be ethically or legally fair.

He said the talks have been a very difficult process, a very sensitive process, and theres no easy answer,adding: Whatever is put in place will undoubtedly upset a lot of people Somehow we have got to find a fair balance.

At least three trans women will be competing at Tokyo 2020 amongst the 11,000 cis athletes, including BMX freestyle rider Chelsea Wolfe of the United States, Brazilian volleyball player Tifanny Abreu, and weightlifter Laurel Hubbard of New Zealand.

A consensus statement published in 2015 allowed trans women to compete in female categories under a series of conditions, which included the athlete publicly declaring that their gender identity is female, with the declaration unable to be changed for a minimum of four years.

These previous guidelines set a permitted level of testosterone level in serum at below 10 nanomoles per litre for one year.

For us just to go and change the level of testosterone without getting the proper framework in place would be wrong, Budgett said.

Were talking about so few out of 11,000 athletes that actually its much better to get this right, or as right as we can, rather than rushing something out just before the games.

Around 98 per cent of women have under 2 nanomoles of testosterone, while for men the amount averages between 7.7 and 29 nanomoles. However, there are many natural variations and hormone levels change for both males and females as they age.

Intersex campaignershave noted that there isno scientific basisthat female athletes born with variations of sex characteristics have any advantage over other female athletes.

Mandatory testosterone testing has beencondemned by the UN Rights Council as an unnecessary, humiliating and harmful, and many academics questionits inclusion in sport at all.

The case of Caster Semenya, a cis female athlete with naturally high testosterone levels, has brought this issue to the fore.

The 800-meter champion from South Africa is fighting a separate case in Switzerland to challenges track and fields rules on naturally high testosterone in female runners with differences in sex development. She could get a ruling within weeks in an appeal case at the Swiss supreme court.

See the original post:
The International Olympic Committee will wait until after Tokyo 2020 to reveal new rules for trans athletes - PinkNews

Freddy McConnellPhoto: Manuel Vazquez for "Seahorse"/Promotional image

Transgender journalist Freddy McConnell is fighting the U.K. government to be listed as the father on his childs birth certificate.

McConnell whose experience with pregnancy as a transgender man was the subject of the documentary Seahorse: The Dad Who Gave Birth is now appealing a September 2019 High Court decision by the president of the courts Family Division stating that McConnell has to be listed as the mother because hes the one who gave birth to the child.

Related:NBA player Dwyane Wades transgender daughter knew she was a girl when she was 3 years old

Though McConnell began testosterone treatments in April 2013 and had a chest reshaping surgery in 2016, he stopped hormones in order to get pregnant using a sperm donor.

According to The Guardian, the laws around McConnells pregnancy created some of his current legal dilemma. The intrauterine insemination fertility treatment McConnell used to get pregnant is governed by the Human Fertilization and Embryology Act 2008, a law that defines treatments as assisting women to carry children.

Hannah Markham, the lawyer representing McConnell, said that the deciding judge incorrectly declared that mother was not a gendered term and that McConnells giving birth was the determining issue in declaring him as the childs mother. Markham said current U.K. law fails to respect the right of transgender people to be legally recognized by their gender identity.

Being misgendered on his childs birth certificate is discrimination and exacerbates his gender dysphoria, McConnell said. Furthermore, it violates both his human rights and right to privacy since a birth certificate listing him as a mother could potentially out him as transgender, inviting intrusive questions about his personal life.

McConnells case could potentially affect an untold number of other transgender parents in the U.K. who have children under similar circumstances.

Heres the trailer for Seahorse, a title thats a reference to how male seahorses carry their species young:

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Trans man is fighting to not be called mother on his child's birth certificate - LGBTQ Nation

PHOENIX, March 6, 2020 (LifeSiteNews) The Arizona House voted 31-29 Tuesday to pass legislation ensuring that female school athletes will only compete against other femalesrather than gender-confused boys who claim to be girls.

House Bill 2706, the Save Women's Sports Act, would allowparticipants in high-school girls and college womens athletics to dispute the biological sex of an athlete they suspect of actually being male, who would then have to produce a signed doctors statement confirming that genetic testing has identified them as female, CBS 5 reported. Accusers would also be shielded from retaliation.

"Women are being displaced in their own sport. The playing field is no longer level," said Republican state Rep. Nancy Barto, the bills author.

Calling the proposed requirement cruel, opponents of the bill claim it could open up transgender students to bullying a charge Barto rejects.

"I would say they're really not looking at the true motive of the bill. It's not singling out anybody and it frankly doesn't discriminate or ban anybody from playing sports, she said, noting that biologically-male athletes could still play on either boys teams or participate in coed sports.

Last June, the Journal of Medical Ethics published a paper concluding that healthy young men (do) not lose significant muscle mass (or power) when their circulating testosterone levels were reduced to (below International Olympic Committee guidelines) for 20 weeks, and indirect effects of testosterone on factors such as bone structure, lung volume, and heart size will not be altered by hormone therapy; therefore, the advantage to transwomen (men) afforded by the (International Olympic Committee) guidelines is an intolerable unfairness.

Such findings are consistent with those of organizations like USA Powerlifting, which contends that men naturally have a larger bone structure, higher bone density, stronger connective tissue and higher muscle density than women. These traits, even with reduced levels of testosterone, do not go away. While MTF (male-to-female) may be weaker and less muscle than they once were, the biological benefits given them at birth still remain over than (sic) of a female.

Nevertheless, grouping athletes based on their claimed gender identity is increasingly common and contentious in the United States and around the world, with many female athletes objecting that they are being denied records and victories meant to denote excellence among actual females.

HB 2706 now advances to the majority-GOP Arizona Senate for consideration. Republican Gov. Doug Ducey has not yet said whether he would sign it into law.

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Bill banning boys who say theyre girls from womens sports passes Arizona House - Lifesite

The Arizona House of Representatives approved a bill on Tuesday that would prohibit transgender women and girls from playing on female school sports teams.

House Bill 2706 would require interscholastic or intramural sports teams sponsored by educational institutions to be expressly designated, based on biological sex, as male, female or mixed sex. Athletes who are not biologically female would be prohibited from playing on teams expressly designated for females.

If a students sex is disputed, that student may submit a physicians statement that indicates that students sex based on internal and external reproductive anatomy, normal endogenously produced testosterone and an analysis of the students genetic makeup.

This bill would affect public schools, community colleges, private schools that are members of interscholastic athletic associations, universities under the jurisdiction of the Arizona Board of Regents and any higher education institutions that are members of collegiate or intercollegiate athletic associations.

The bill passed by a vote of 31 to 29. It will now go to the Arizona Senate.

Original post:
Arizona House approves bill that would bar transgender girls from girls' sports teams - JURIST

A research report added to the repository of eonmarketresearch.com details the historical data of the global Testosterone Replacement Therapy market and assesses the present market scenario based on the important factors influencing the trajectory of this Testosterone Replacement Therapy market. With the help of primary and secondary data, the Testosterone Replacement Therapy market research report predicts the future of this Testosterone Replacement Therapy market and makes valid projections. Furthermore, the Testosterone Replacement Therapy industry research report also includes insightful inputs from industry experts to help the readers make well-informed business decisions. The Testosterone Replacement Therapy market report also uses SWOT analysis and Porters five forces analysis to highlight the key elements of the Testosterone Replacement Therapy Market.

Global Testosterone Replacement Therapy Market gives insights into the major driving factors, restraints, and major trends in the Testosterone Replacement Therapy market and analyzes their impact on the Testosterone Replacement Therapy markets developmental prospects over the reports forecast period.

The global Testosterone Replacement Therapy market research report takes a chapter-wise approach in explaining the dynamics and trends in the Testosterone Replacement Therapy industry. Divided into 13 chapters, each chapter explains various aspects of the market in absolute detail. The Testosterone Replacement Therapy market report opens with an overview of the Testosterone Replacement Therapy industry, which contains definitions and specifications pertaining to the industry. In the following chapter, the Testosterone Replacement Therapy market report explains the manufacturing cost structure, which includes a thorough analysis of the raw material suppliers and price analysis, equipment suppliers and price analysis, and analysis of labor costs and other costs.

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The report analyzes the key players in the global Testosterone Replacement Therapy market such as

AbbVieAllerganBayerEli Lilly and CompanyKyowa Kirin InternationalNovartisPfizer

Market Segment by Product Type

General Type

Market Segment by Application

Medical

Market size split by Region North America, United States, Canada, Mexico, Asia-Pacific, China, India, Japan, South Korea, Australia, Indonesia, Malaysia, Philippines, Thailand, Vietnam, Europe, Germany, France, UK, Italy, Russia, Central & South America, Brazil, Rest of Central & South America, Middle East & Africa, GCC Countries, Egypt, South Africa.

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It also explains the competitive landscape of the Testosterone Replacement Therapy market and the regulatory framework influencing the Testosterone Replacement Therapy market. Furthermore, the Testosterone Replacement Therapy industry report shares details pertaining to the financial overview, research and development activities, investment outlook, business and marketing strategies, and product portfolio of the key players in the global Testosterone Replacement Therapy industry.

The Testosterone Replacement Therapy market report also evaluates the technical data and manufacturing plants analysis, capacity, production, and revenue analysis by type, region, and manufacturers, price, cost, gross, and gross margin analysis, consumption volume, consumption value, and sale price analysis of the Testosterone Replacement Therapy market. The Testosterone Replacement Therapy industry report also offers regional segmentation of the global Testosterone Replacement Therapy market to help the readers understand the specific market drivers, restraints, threats, and opportunities impacting this Testosterone Replacement Therapy market.

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Eon Market Research (EMR) is a market intelligence company, providing global business information reports and services. Our exclusive blend of quantitative forecasting and trends analysis provides forward-looking insight for thousands of decision-makers.

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Global Testosterone Replacement Therapy Market 2025 Forecasts and Analysis with Top Key Players like -AbbVie, Allergan - Fashion Trends News

Higher levels of genetically derived testosterone are associated with an increased risk of type 2 diabetes and polycystic ovary syndrome (PCOS) in women but play a protective role against type 2 diabetes in men, according to a study in Nature Medicine.

Researchers from the United States, United Kingdom, and Europe examined testosterone levels and genetic data from 425,097 patients in the UK Biobank. The researchers investigated 2571 genome-wide significant trait/signal pairs, which ranged from 22 signals for estradiol in men to 658 signals for sex hormone-binding globulin in a sex-combined cohort. The findings from the analyses were verified in the EPIC-Norfolk and Twins UK studies, which demonstrated a high level of agreement with the UK Biobank analysis. Mendelian randomization was also used to identify potential causal associations between testosterone levels and disease risk.

The investigators found differences in genetic determinants of testosterone levels between men and women, with higher testosterone showing harmful and protective effects on women and men, respectively. In women, a genetically determined, per 1-standard deviation (SD) higher level of bioavailable testosterone was associated with an increased risk of type 2 diabetes (odds ratio [OR], 1.37; 95% CI, 1.22-1.53) and PCOS (OR, 1.51; 95% CI, 1.33-1.72). Conversely, a 1-SD higher testosterone level was associated with reduced risk of type 2 diabetes risk in men (OR, 0.86; 95% CI, 0.76-0.98). Testosterone was also associated with an increased risk of estrogen receptor (ER)-positive breast cancer and endometrial cancer.

A limitation of the study was the use of a single large study enriched for healthy, older people to determine genetic variants. According to the investigators, this may have underestimated the effect size of the associated variants.

The investigators concluded that while these findings relating to adverse metabolic effects of testosterone in women may inform clinical practice, it is premature to infer wider beneficial metabolic effects in men.

Disclosure: Several study authors declared affiliations with the pharmaceutical industry. Please see the original reference for a full list of authors disclosures.

Reference

Ruth KS, Day FR, Tyrrell J, et al. Using human genetics to understand the disease impacts of testosterone in men and women. Nat Med. 2020;26(2):252-258.

Link:
High Levels of Genetically Determined Testosterone Lead to Adverse Metabolic Effects in Women - Medical Bag

The testosterone-related genetic variantHSD3B1was found to be associated with earlier castration resistance and shorter overall survival (OS) in men with low-volume metastatic prostate cancer, according to a study published inJAMA Oncology.

Given these findings,HSD3B1may help identify more men who are likely to benefit from escalated androgen receptor axis inhibition beyond gonadal testosterone suppression according to the researchers.1

These findings lay the groundwork for more personalized and effective treatments for prostate cancer, senior author Nima Sharifi, MD, of Cleveland Clinics Lerner Research Institute, said in a press release.2If men carry this specific testosterone-related genetic abnormality we may be able to individualize their therapy.

Using the phase III E3805 Chemo-hormonal Therapy vs Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer (CHAARTED), researchers analyzed 527 available DNA samples and retrospectively determined theHSD3B1germline genotype in 475 white men. The patients were then randomized to castration plus docetaxel (Taxotere) at 75 mg/m2every 3 weeks for 6 cycles or castration alone, and clinical outcomes were evaluated by genotype.

Of the study cohort, 270 patients (56.8%) inherited the adrenal-permissive genotype (1HSD3B1[1245C] allele). Freedom from castration-resistant prostate cancer at 2 years was diminished in men with low-volume disease with the adrenal-permissive (51.0% [95% Ci, 40.9%-61.2%]) compared to the adrenal restrictive genotype (70.5% [95% CI, 60%-80.9%]) (P= 0.01).

At 5 years, OS was worse in men with low volume disease with the adrenal-permissive genotype (57.5% [95% CI, 47.4%-67.7%] vs 70.8% [95% CI, 60.3%-81.3%] [P= 0.03]). Moreover, hazard ratios were 1.89 (95% CI, 1.13-3.14;P= 0.02) for castration-resistant prostate cancer and 1.74 (95% CI, 1.01-3.00;P= 0.045) for death.

There was no association found between genotype and outcomes in men with high-volume disease. Further, there was no interaction between genotype and benefit from docetaxel.

These findings represent a 7-year research story that started at the lab bench and has now reached the patient bedside, said Sharifi. As the team has shown here, incorporating genetic testing in prostate cancer as part of routine care has significant potential to improve treatment success and quality and length of life for men with prostate cancer who carry theHSD3B1(1235C) variant. This work is another step in that direction.

Researchers indicated that further studies are warranted to evaluate whether potent androgen receptor antagonists might directly overcome the tumor growth advantage transmitted by theHSD3B1(1245C) allele and yield particular benefit for patients with low-volume disease who have the adrenal permissive genotype. Moreover, a notable limitation of the study is that the analysis was restricted to white men given that white patients accounted for 85% of all of the trial participants.

This information could assist clinicians in counseling patients and guide researchers in identifying those for whom escalated androgen receptor axis inhibition beyond mere gonadal testosterone suppression is most warranted, the authors wrote. Accordingly,HSD3B1genotype could be used as a stratification factor for patients with low-volume disease in future clinical trials.

References:

1. Hearn JWD, Sweeney CJ, Almassi N, et al.HSD3B1Genotype and Clinical Outcomes in Metastatic Castration-Sensitive Prostate Cancer.JAMA Oncology; 2020. doi:10.1001/jamaoncol.2019.6496.

2. Researchers Validate Link Between Genetic Variant and Poor Outcomes in Men with Advanced Prostate Cancer [news release]. Cleveland, Ohio. Published February 13, 2020. newswise.com/articles/researchers-validate-link-between-genetic-variant-and-poor-outcomes-in-men-with-advanced-prostate-cancer?sc=mwhr&xy=10021790. Accessed March 4, 2020.

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HSD3B1 May Be Associated with Earlier Castration Resistance, Shorter OS in Prostate Cancer - Cancer Network

The tide is turning against gender reassigning procedures for minors. I Wikimedia Commons

Judges and legislators across the country are taking up pediatric gender treatment. Finally, our government is prioritizing the protection of children, one of its most important duties, above a parents right to wokeness.

In October, Sydney Wright, an ex-trans man, wrote her story for the Daily Signal called I Spent a Year as a Trans Man. Doctors Failed Me at Every Turn. Embarrassed by the looks shed receive in public while holding hands with girlfriends in high school, Wright became envious of the happy transgender men on Instagram who could.

Without her parents consent, Wright found a therapist who helped her acquire the letter needed to begin a testosterone regimen. When she handed the letter to her doctor, he didnt even open it before writing her prescription. When she asked with surprise if he wasnt going to give her the shot himself, he told her to figure it out at home and to consult YouTube if she needed help.

Six months and 50 pounds later, with pre-diabetes and heart problems, Wright felt trapped. She hadnt found the happiness she sought and was too embarrassed to change her mind about such a grave decision. Wrights grandpa was the first person to ask her to stop the treatments. She quit cold turkey and is finally regaining a sense of normalcy after months in and out of the hospital from withdrawal symptoms.

Wrights story unfortunately isnt special. She tells the story of all those sacrificed on the altar of American wokeness.

Thankfully, judges and legislators are taking notice of stories like Wrights, and the tide is turning. Brave adults are finally daring to admit that they see and hear the voices of the children whose lives are on the line.

Last month, Ohio representatives Ron Hood and Bill Dean introduced the Vulnerable Child Protection Act. If passed into law, the bill would criminalize any medical professional who performs treatment on a minor which changes a childs reproductive anatomy, delays or prevents puberty, or disrupts production of sex hormones such as estrogen and testosterone, among other more widely-accepted violations of medical ethics, like restraining or inflicting pain on a minor.

Rob Hoogland is an Alabama father of a 12-year-old. Last year, his daughters school counselor told her that she was a boy, and the school picked out a boys name and treated her as a boy without informing her parents. Two years later, Hoogland was fighting his 14-year-old in court over the initiation of testosterone treatments. The courts ruled, all too typically, against the will of the parents. Hoogland speaks out now and warns other parents against complacency: Dont think it cant happen to you.

After hearing stories like the Hooglands, the house and senate of Alabama are working to pass a bill similar to Ohios, called the Vulnerable Child Compassion and Protection Act.

It is time for parents, not just lawmakers and judges, to rise to the occasion to fight for the family.

Society has crumbled under the weight of its inverted priorities. A healthy society is structured like a pyramid: first, personhood; then, the family; then, the neighborhood, the community, the state, and finally, the country. This arrangement is called subsidiarity, taken from the Latin subsidias, meaning help. It makes sense, too: the entire structure is ordered toward the priority of the person. The larger orders, like the government, only interfere with the smaller orders, like your local community, when the smaller orders cannot solve the problem on their own.

The entire structure is aimed not at financial equity or distributing privilege, but far more importantly at the dignity of each person. Subsidiarity looks like individuals helping themselves first, and parents protecting their dependent children, and communities helping when parents cant. In the rare circumstances that exceed the abilities of a community, the state will step in. And finally, when all else has failed, the federal government will help.

In our current state of affairs, the individual often turns immediately to federal welfare. The perverse concept of seeking help first from a stranger rather than those closest to us is bolstered by the effects of social media; a major influence in Wrights gender transition were the Instagram snapshots of apparently happy transgender men. Meanwhile, her parents stood by and despaired as they watched their daughter destroy herself. It is easy to see how personal dignity is being smothered, not empowered, by this unstable upside-down pyramid.

The stances taken in Ohio and Alabama are a promising start, but laws wont change the heart of our nation. If we want to protect the youth of America, its up to local communities: Parents ought to stand up for their children, and friends ought to stand up for their friends.

Gender treatment therapy is bad for kids, and its about time we admit it.

Reagan Cool is a senior studying philosophy and religion. She is a columnist on faith and culture.

More:
State courts stand up to woke America and gender therapy - Hillsdale Collegian

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