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Moles live a tough life underground. As a result, theyve evolved helpful adaptations, such as excavator-like claws. Female moles in particular have evolved an unusual strategy: high levels of the male hormone testosterone.

This is an evolutionary advantage. It produces stronger muscles for digging and foraging and aggression, to help mothers defend themselves and their young.

Most of the year, female moles look and behave like males. They have masculinised genitals, with no external vagina and an enlarged clitoris. But when mating season comes, testosterone levels drop and a vagina is formed; mating and birth follow.

How they accomplish this remained a mystery for a long time. But now, the complete sequencing of the mole genome has revealed the genetic tweaks underpinning this strange cycle in female moles, by which reproductive organs (gonads) develop and hormones are produced.

Male development in humans and other mammals is determined by chromosomes (the structures within cells of living things that contain genes). Females have two copies of an X chromosome. Males have a single X and a male-specific Y chromosome.

In XY embryos, a gene called SRY on the Y chromosome intervenes in a network of another 60 genes. SRY turns on testis genes and turns off ovary genes to transform a ridge of cells into a testis.

In the testis, one cell type becomes specialised to make sperm and another (Leydig cells) makes male hormones, including testosterone.

Read more: What makes you a man or a woman? Geneticist Jenny Graves explains

Testosterone is responsible for the most visible sex differences in males, such as bigger bodies, more muscle mass, male genitalia and more aggression. In XX embryos, an alternate pathway makes an ovary, which pumps out oestrogen.

So in mammals, different genetic pathways drive the same patch of embryonic tissue to become either an ovary or a testis. Generally, theres no in-between.

But female moles have a patch of testis within their ovaries.

In 1993, it was discovered the basis for intersex development in female moles is a gonad with both ovarian and testicular tissue.

Like other male mammals, male moles have a Y chromosome, bearing the SRY gene which directs testis formation.

Also like other mammals, female moles lack a Y chromosome. Curiously, however, instead of developing ovaries they develop ovotestes, with ovarian tissue at one end and testicular tissue at the other.

The ovarian tissue makes eggs and gets larger during breeding, then regresses. The testicular tissue is full of Leydig cells that make testosterone (but not sperm). Outside of breeding season, it expands until its larger than the ovarian end.

This explains why female moles have male-like genitalia, and are muscular and aggressive. But how does a patch of testis form in female moles if they have no SRY gene to trigger the process?

To look for genetic changes that could allow this to happen, a global consortium of scientists sequenced the entire mole genome.

They found no differences between moles and other mammals in the protein products of the 60-odd genes involved in sex determination. However, they did discover mutations that altered the regulation of two of these genes in female moles.

One difference was found in the DNA sequences of a gene thats vital for developing testes: FGF9. In all mammals, this gene switches on testis growth in XY embryos and inhibits genes that determine ovarian development.

In females of other mammals, the FGF9 gene is turned off in the absence of SRY, but in female moles it stays on.

Genome sequencing revealed why: a big patch of DNA just upstream of FGF9 is flipped around in moles. This inversion removes the usual control sequences from the gene, allowing it to stay on for longer in XX embryos.

The other gene impacted in female moles is CYP17A1, which codes for an enzyme thats key to producing androgens (male hormones). In female moles, this gene and its surrounds have two extra copies, which increases testosterone output.

To show these genomic changes were indeed responsible for masculinising female moles, the researchers introduced them into mice, causing sex reversal and higher testosterone levels.

Its important to note these evolutionary changes are in the regulation of gene activity, rather than in the regulation of protein products which could compromise other normal functions.

Read more: What we learn from a fish that can change sex in just 10 days

Since mammals, including humans, develop as either males or females, weve been accustomed to regard testis or ovary development in the embryo as strict alternatives, depending on an on/off switch (the presence or absence of the Y chromosome and SRY gene).

But we now know theres a complex gene network full of checks and balances that is the basis for alternate pathways of sexual development.

There are many studies of human babies born with mutations in one of these genes. This points to a more complex picture of the wiring behind the switch responsible for variation in human sexual development.

There are fierce females in other mammal species, too. Female spotted hyenas are bigger and more dominant than males and have male-like genitalia. We dont know how this change works at a genetic level.

The downside of this is that mating is tricky. Cubs are birthed through the females narrow phallus. Mothers and/or cubs often die during this fraught process.

So while these larger, more aggressive females rule the hyena roost and get first pick at meals, like most things in nature, it seems this comes at a price.

Big fierce female moles and hyenas remind us the natural world, as always, features unique evolutionary differences enlightening our view on human variation.

More:
Fierce female moles have male-like hormones and genitals. We now know how this happens. - The Conversation AU

Final Report will add the analysis of the impact of COVID-19 on this industry.

November 2020:

The recent report entitled Global Testosterone Replacement Therapy Market Size, Status and Forecast 2020-2027 offered by Coherent Market Insights, comprises a comprehensive investigation into the geographic landscape, industry size and business revenue estimate. In addition, the report also highlights the challenges that hinder market growth and the expansion strategies employed by leading companies in the Testosterone Replacement Therapy market.

This is the most recent report that includes the effects of COVID-19 on the functioning of the market. It is well known that some changes, for the worse, were managed by the pandemic in all industries. The current scenario of the business sector and the impact of the pandemic on the industrys past and future are addressed in this report.

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In the market segmentation by manufacturers, the report covers the following companies:

AbbVie, Inc., Bayer AG, Endo Pharmaceuticals, Inc., Eli Lilly and Company, Kyowa Kirin International plc, Pfizer, Inc., Acerus Pharmaceuticals Corporation, and Perrigo Company plc.

Detailed Segmentation:

By Active Ingredient TypeTestosteroneMethyl TestosteroneTestosterone UndecanoateTestosterone EnanthateTestosterone CypionateBy Route of AdministrationInjectablesParenteral

Testosterone Replacement Therapy Market regional analysis includes:

Asia-Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia and Australia)

Europe (Turkey, Germany, Russia, United Kingdom, Italy, France, etc.)

North America (United States, Mexico and Canada).

South America (Brazil etc.)

Middle East and Africa (GCC countries and Egypt).

The survey provides answers to the following key questions:

What is the expected growth rate of the Testosterone Replacement Therapy market? How big will the market be for the forecast period, 2020-2027?

What are the main drivers responsible for transforming the sectors trajectory?

Who are the main suppliers that dominate the Testosterone Replacement Therapy industry in different regions? What are the winning strategies to stay ahead of the competition?

What are the market trends that entrepreneurs can trust in the coming years?

What are the threats and challenges expected to restrict the progress of the industry in different countries?

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Regional Demand Estimation and Forecast

Pre-commodity price volatility

Analysis of technological updates

Analysis of Location Quotients

Competitive analysis

Matrix of product mix

Supplier management

Cost-benefit analysis

Supply chain optimization analysis

Patent Analysis

Carbon footprint analysis

R&D analysis

Fusions and acquisitions

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Testosterone Replacement Therapy Market Report 2020 Growth of Industry, Manufacturing, Value, Consumption, Status and Forecast for 2027 -...

The Global Testosterone Replacement Therapy Market report, published by Reports and Data, is an extensive compilation of the essential aspects of the global Testosterone Replacement Therapy market, assessed thoroughly by our team of researchers. The market intelligence report offers insightful data and information relevant to the market to acquaint the readers with the lucrative growth prospects existing in this industry, eventually helping them formulate effective business strategies. The global Testosterone Replacement Therapy market report has been methodically curated using industry-verified data to offer information concerned with the leading manufacturers and suppliers engaged in this sector. It further focuses on their pricing analysis, gross revenue, product portfolio, sales network & distribution channels, profit margins, and financial standing.

Get a sample of the report @ https://www.reportsanddata.com/sample-enquiry-form/229

Competitive Landscape:

The global Testosterone Replacement Therapy market is highly consolidated due to the presence of a large number of companies across this industry. The report discusses the current market standing of these companies, their past performances, demand and supply graphs, production and consumption patterns, sales network, distribution channels, and growth opportunities in the market. Moreover, it highlights the strategic approaches of the key players towards expanding their product offerings and reinforcing their market presence.

The report covers extensive analysis of the key market players in the market, along with their business overview, expansion plans, and strategies. The key players studied in the report include:

The report further sheds light on the various strategic business initiatives undertaken by the key market contenders to fortify their foothold in this business sector. These strategies majorly include mergers & acquisitions, partnerships & collaborations, joint ventures, government and corporate deals, brand promotions, new product launches, and numerous others. In the later part of the report, the major components of the Testosterone Replacement Therapy industry, such as product type, application gamut, end-use industries, and the solutions and services offered by the leading manufacturers, have been analyzed. Numerical data and subjective information pertaining to each market segment have been featured in the report for better understanding.

Therefore, the latest research document includes competitive analysis, key market players, crucial industry-related facts & figures, sales revenue, product prices, gross margins, market shares, business strategies, dominant regions, and key developments.

In market segmentation by types of Testosterone Replacement Therapy, the report covers-

In market segmentation by applications of the Testosterone Replacement Therapy, the report covers the following uses-

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The report encompasses the significant effects of the coronavirus pandemic on the Testosterone Replacement Therapy market and its key segments. The report offers a vivid picture of the current market scenario, closely investigating the impact of the pandemic on this specific business sphere, its leading players, supply chains, distribution channels, and its global scenario. The pandemic has affected the global industry extensively, subsequently disrupting the Testosterone Replacement Therapy market mechanism. Furthermore, the research study examines the Testosterone Replacement Therapy market and the recent disruptive changes in the business setting that followed the outbreak. Also, the future effects of the pandemic on the market have been assessed in the report.

Key Geographies Encompassed in the Report:

Market Taxonomy:

Chapter 1: Methodology & Scope

Chapter 2: Executive Summary

Chapter 3: Industry Insights

Chapter 4: Regional Landscape

Chapter 5: Competitive Outlook

To read more about the report, visit @ https://www.reportsanddata.com/report-detail/global-testosterone-replacement-therapy-market-by-manufacturers-countries-type-and-application-forecast-to-2022

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Read this article:
Testosterone Replacement Therapy Market Report: Price, New Entrants SWOT Analysis, Competitive Landscape and Gross Margin Forecasted by 2027, Analysis...

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Testosterone Booster Market To Witness Growth Acceleration During 2020 to 2025 - News by aeresearch

A referee holds a basketball on March 1. (Ryan Schmidt | The Collegian)

In honor of Transgender Awareness Week, The Collegian sports desk decided to take a deeper look into the National Collegiate Athletic Associations rules and regulations pertaining to transgender athletes and, more importantly, the type of college experience these rules create for transgender athletes. In 2011, the NCAA released a transgender inclusion handbook and the rules it laid out for competition are still followed today.

According to the NCAA Inclusion of Transgender Athletes Handbook, the two primary rules regarding transgender athlete participation are as follows:

1. A trans male (female-to-male) student-athlete who has received a medical exception for treatment with testosterone for diagnosed Gender Identity Disorder or gender dysphoria and/or Transsexualism, for purposes of NCAA competition may compete on a mens team, but is no longer eligible to compete on a womens team without changing that team status to a mixed team.

2. A trans female (male-to-female) student-athlete being treated with testosterone suppression medication for Gender Identity Disorder or gender dysphoria and/or Transsexualism, for the purposes of NCAA competition may continue to compete on a mens team but may not compete on a womens team without changing it to a mixed team status until completing one calendar year of testosterone suppression treatment.

Both of these regulations center around hormone treatments with a focus primarily on testosterone. The NCAAs goals for the aforementioned rules are to create an inclusive environment for transgender athletes while also preserving the current level of competitive fairness in collegiate athletics.

While those are fine goals to have, many transgender athletes have been adversely affected by hormone treatments required for them to be able to participate on teams of the gender they identify with. The United Nations categorized the hormone suppression required for a transgender woman to participate in collegiate athletics asunnecessary, humiliating and harmful.

Some experts in the field of sports medicine have questioned if these extensive procedures to preserve fairness are even worth it given that the natural athletic ability already varies greatly between members of the same sex. Geneticist Dr. Eric Vilain, who has collaborated with the NCAA and the International Olympic Committee on transgender participation, compared questioning a transgender womans competitive advantage to questioning whether or not dominant athletes like Usain Bolts natural abilities are fair.

The only thing abundantly clear about transgender athletes participation in collegiate athletics is that it is a very divisive subject. The NCAA moves and changes regulations with caution. With inclusion and competitive fairness being the hallmark drivers in changing collegiate athletic legislative changes, transgender athletes will have to wait for future changes.

Despite the aforementioned gridlock regarding transgender participation, there have been a handful of success stories, none of which are more notable than 400-meter dash national champion CeC Telfer. Telfer ran the 400-meter and 100-meter hurdles for Franklin Pierce University, and in 2019, she captured a Division II National Championship in the 4oo-meter.

Upon graduating from college, Telfer has taken time to reflect on those who criticized her victory by claiming she had an unfair athletic advantage. According to Dawn Ennis, those claims could not be further from the truth. As a transgender woman on hormone suppressants, Telfers trainer highlighted that it resulted in noticeable muscle loss along with a decrease in her initial burst out of the blocks.

However, Telfer did not let these mental and physical setbacks prevent her from competing. Instead, Telfer chose to only channel positive energy provided by her coaches, friends and family and use that as fuel during her races. Unfortunately, when the races were over, Telfer regularly faced backlash from the media and other competitors.

Rather than being celebrated for her accomplishments, Telfer was chastised for partaking in the sport she loved, and nobody seemed to address changes to NCAA regulations that needed to happen. The NCAAs regulations regarding transgender athletes participation are far from perfect, but hatred from the media and other competitors is doing nothing to help solve these complex problems.

Hopefully, the future of transgender participation in collegiate athletics is one where compassion outweighs prejudice and collaboration leads to progress rather than division.

Ethan Lee can be reached atsports@collegian.comor on Twitter@EthanLee_99.

Read this article:
The relationship between the NCAA and transgender athletics - Rocky Mountain Collegian

Several factors can cause or contribute to erectile dysfunction. One example is the medications a person takes. Medicines that affect sex drive, blood flow, and sexual organ function may increase the incidence of erectile dysfunction.

Erectile dysfunction (ED) is the inability to achieve or maintain an erection. It is a common condition that affects males of all ages and varying levels of health and fitness.

This article lists some medications that may cause or contribute to ED, and outlines some treatment options. Finally, we offer some tips to help prevent ED.

Certain medications may contribute to ED, although they are not usually the sole cause of the condition.

A person who suspects their ED may be due to a particular medication should talk to their doctor. Where possible, a healthcare professional may recommend changing the dosage or switching medicines.

A person should not stop taking their medications unless their doctor tells them to do so.

Some medications that may contribute to ED are below.

Anti-hypertensives are prescription medications to help lower blood pressure. They may contribute to ED, though doctors have not yet established why this is the case.

Examples include:

Immunosuppressants reduce the activity of the immune system. A person may take them to help control an autoimmune condition or prevent organ rejection following an organ transplant procedure.

One potential side effect of immunosuppressants is impaired sexual function.

Examples include:

Androgens are hormones associated with male characteristics. Anti-androgens block some aspect of these hormones. Doctors may prescribe them for several conditions, such as heartburn or prostate cancer.

Examples of anti-androgens include:

Gonadotropin-releasing hormone (GnRH) agonists are a class of medications that doctors sometimes prescribe to treat prostate cancer. They may reduce sexual desire in men.

Examples include:

Corticosteroids are drugs that mimic the effects of certain hormones inside the body. People typically take them to help reduce inflammation.

These drugs can also reduce testosterone levels. This may lead to decreased sexual desire and sexual function in some men.

Examples of corticosteroids include:

Antidepressants are medications that doctors may prescribe to treat or prevent the recurrence of clinical depression.

Some antidepressants may inhibit sexual desire, which may affect sexual performance. Others may also delay ejaculation.

Examples of antidepressants that may cause ED include:

Antipsychotics are drugs primarily prescribed for the treatment of psychosis. They may inhibit sexual desire, which may then affect sexual performance.

Examples include:

Anti-epileptics are medications that doctors prescribe to help prevent epileptic seizures. They may affect a mans ability to orgasm.

Examples include:

Aside from medications, some recreational drugs can also affect sexual arousal and performance. Examples include:

Drugs to treat opioid addiction may also lead to erectile dysfunction. These drugs include methadone and buprenorphine.

ED is the medical term for when a person has difficulty achieving or maintaining an erection. While this may occur periodically for all males, those with ED experience more frequent and routine episodes.

The ability to achieve and maintain an erection is dependant on several factors, including:

An issue with any of the above factors may lead to ED.

A doctor may recommend treatments that can enhance sexual performance while allowing a person to continue taking potentially life-saving or life-extending medications. Some examples are below.

Often, ED treatments begin with making changes to a persons routine. These include:

Males who experience mental health issues, such as stress, anxiety, or depression, may also benefit from seeing a mental health professional. These conditions can negatively impact sexual desire and sexual function. As a result, successful treatment may help manage ED.

A doctor may prescribe one of the following medications to help treat ED.

Phosphodiesterase type-5 (PDE 5) inhibitors are medications that relax and widen the blood vessels to promote blood flow. The American Urological Association (AUA) recommend that males take PDE 5 inhibitors 12 hours before having sex.

Examples of PDE 5 inhibitors include:

PDE 5 inhibitors are not suitable for people taking nitrates.

A vasodilator is a medication that helps widen the blood vessels, increasing blood flow.

One potential ED treatment involves injecting the vasodilator directly into the penis or urethra.

According to the AUA, the vast majority of ED cases are due to reduced blood flow to the penis. They add that low testosterone levels may affect a persons sex drive, but are rarely the cause of ED.

If low testosterone levels contribute to ED, a doctor may consider testosterone therapy (TT). This technique involves regularly administering testosterone in one of the following forms:

However, the AUA state that TT does not improve erections in males with normal testosterone levels or in those with low testosterone levels who experience ED as their only symptom.

A vacuum erection device (VED) consists of a plastic tube and a pump. The plastic tube fits over the penis, forming a seal against the bodys skin. Using the pump creates a vacuum around the penis, which causes an erection.

Once the penis is erect, the person slips an elastic ring onto the base of the penis. This retains the blood inside the penis for up to 30 minutes.

According to the AUA, around 75% of males who receive proper training on using a VED can achieve an erection when using these devices.

If lifestyle measures and medical treatments are ineffective, doctors may recommend surgical options for ED. These are outlined below.

The main surgical option for ED is inserting a penile implant. This device sits permanently inside the penis, making it rigid enough for a person to have sex.

There are two types of penile implant:

Vascular surgery for ED helps improve blood flow to the penis. Doctors usually reserve this procedure for younger males with good vascular with ED due to pelvic trauma.

Adopting a healthful lifestyle may help improve a persons physical and mental health, which may reduce the incidence of ED.

Some general tips include:

Erectile dysfunction is a common condition among males of all ages. Certain medications that affect sex drive, blood flow, or sexual organ function may contribute to ED.

Anyone who has concerns that their ED may be due to a particular medication should talk to their doctor. However, people should not stop taking their medicines unless their doctor tells them it is safe.

If it is not possible to switch medications or alter the dose of the existing medication, a doctor may recommend alternative treatments for ED. Possible options include using vacuum erection devices, a penile implant, or sugery.

A person can talk to a healthcare professional to explore suitable treatment options according to their needs.

See the article here:
Medications that cause erectile dysfunction: Types and treatment - Medical News Today

The global Testosterone Replacement Therapy market is broadly analyzed in this report that sheds light on critical aspects such as the vendor landscape, competitive strategies, market dynamics, and regional analysis. The report helps readers to clearly understand the current and future status of the global Testosterone Replacement Therapy market. The research study comes out as a compilation of useful guidelines for players to secure a position of strength in the global Testosterone Replacement Therapy market. The authors of the report profile leading companies of the global Testosterone Replacement Therapy market, such as AbbVie, Endo International, Eli lilly, Pfizer, Actavis (Allergan), Bayer, Novartis, Teva, Mylan, Upsher-Smith, Ferring Pharmaceuticals, Kyowa Kirin, Acerus Pharmaceuticals They provide details about important activities of leading players in the competitive landscape.

The report predicts the size of the global Testosterone Replacement Therapy market in terms of value and volume for the forecast period 2019-2026. As per the analysis provided in the report, the global Testosterone Replacement Therapy market is expected to rise at a CAGR of XX % between 2019 and 2026 to reach a valuation of US$ XX million/billion by the end of 2026. In 2018, the global Testosterone Replacement Therapy market attained a valuation of US$_ million/billion. The market researchers deeply analyze the global Testosterone Replacement Therapy industry landscape and the future prospects it is anticipated to create.

This publication includes key segmentations of the global Testosterone Replacement Therapy market on the basis of product, application, and geography (country/region). Each segment included in the report is studied in relation to different factors such as consumption, market share, value, growth rate, and production.

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The comparative results provided in the report allow readers to understand the difference between players and how they are competing against each other. The research study gives a detailed view of current and future trends and opportunities of the global Testosterone Replacement Therapy market. Market dynamics such as drivers and restraints are explained in the most detailed and easiest manner possible with the use of tables and graphs. Interested parties are expected to find important recommendations to improve their business in the global Testosterone Replacement Therapy market.

Readers can understand the overall profitability margin and sales volume of various products studied in the report. The report also provides the forecasted as well as historical annual growth rate and market share of the products offered in the global Testosterone Replacement Therapy market. The study on end-use application of products helps to understand the market growth of the products in terms of sales.

Global Testosterone Replacement Therapy Market by Product: , Gels, Injections, Patches, Other Market

Global Testosterone Replacement Therapy Market by Application: Hospitals, Clinics, Others

The report also focuses on the geographical analysis of the global Testosterone Replacement Therapy market, where important regions and countries are studied in great detail.

Global Testosterone Replacement Therapy Market by Geography:

Methodology

Our analysts have created the report with the use of advanced primary and secondary research methodologies.

As part of primary research, they have conducted interviews with important industry leaders and focused on market understanding and competitive analysis by reviewing relevant documents, press releases, annual reports, and key products.

For secondary research, they have taken into account the statistical data from agencies, trade associations, and government websites, internet sources, technical writings, and recent trade information.

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Key questions answered in the report:

Table Of Contents:

Table of Contents 1 Report Overview1.1 Research Scope1.2 Top Testosterone Replacement Therapy Manufacturers Covered: Ranking by Revenue1.3 Market Segment by Type1.3.1 Global Testosterone Replacement Therapy Market Size by Type: 2015 VS 2020 VS 2026 (US$ Million)1.3.2 Gels1.3.3 Injections1.3.4 Patches1.3.5 Other1.4 Market Segment by Application1.4.1 Global Testosterone Replacement Therapy Consumption by Application: 2015 VS 2020 VS 20261.4.2 Hospitals1.4.3 Clinics1.4.4 Others1.5 Study Objectives1.6 Years Considered 2 Global Market Perspective2.1 Global Testosterone Replacement Therapy Revenue (2015-2026)2.1.1 Global Testosterone Replacement Therapy Revenue (2015-2026)2.1.2 Global Testosterone Replacement Therapy Sales (2015-2026)2.2 Testosterone Replacement Therapy Market Size across Key Geographies Worldwide: 2015 VS 2020 VS 20262.2.1 Global Testosterone Replacement Therapy Sales by Regions (2015-2020)2.2.2 Global Testosterone Replacement Therapy Revenue by Regions (2015-2020)2.3 Global Top Testosterone Replacement Therapy Regions (Countries) Ranking by Market Size2.4 Testosterone Replacement Therapy Industry Trends2.4.1 Testosterone Replacement Therapy Market Top Trends2.4.2 Market Drivers2.4.3 Testosterone Replacement Therapy Market Challenges 2.4.4 Porters Five Forces Analysis2.4.5 Primary Interviews with Key Testosterone Replacement Therapy Players: Views for Future 3 Competitive Landscape by Manufacturers3.1 Global Top Testosterone Replacement Therapy Manufacturers by Sales (2015-2020)3.1.1 Global Testosterone Replacement Therapy Sales by Manufacturers (2015-2020)3.1.2 Global Testosterone Replacement Therapy Sales Market Share by Manufacturers (2015-2020)3.1.3 Global 5 and 10 Largest Manufacturers by Testosterone Replacement Therapy Sales in 20193.2 Global Top Manufacturers Testosterone Replacement Therapy by Revenue3.2.1 Global Testosterone Replacement Therapy Revenue by Manufacturers (2015-2020)3.2.2 Global Testosterone Replacement Therapy Revenue Share by Manufacturers (2015-2020)3.2.3 Global Testosterone Replacement Therapy Market Concentration Ratio (CR5 and HHI)3.3 Global Top Manufacturers by Company Type (Tier 1, Tier 2 and Tier 3) (based on the Revenue in Testosterone Replacement Therapy as of 2019)3.4 Global Testosterone Replacement Therapy Average Selling Price (ASP) by Manufacturers3.5 Key Manufacturers Testosterone Replacement Therapy Plants/Factories Distribution and Area Served3.6 Date of Key Manufacturers Enter into Testosterone Replacement Therapy Market3.7 Key Manufacturers Testosterone Replacement Therapy Product Offered 3.8 Mergers & Acquisitions, Expansion Plans 4 Market Size by Type4.1 Global Testosterone Replacement Therapy Historic Market Review by Type (2015-2020)4.1.2 Global Testosterone Replacement Therapy Sales Market Share by Type (2015-2020)4.1.3 Global Testosterone Replacement Therapy Revenue Market Share by Type (2015-2020)4.1.4 Testosterone Replacement Therapy Price by Type (2015-2020)4.1 Global Testosterone Replacement Therapy Market Estimates and Forecasts by Type (2021-2026)4.2.2 Global Testosterone Replacement Therapy Sales Forecast by Type (2021-2026)4.2.3 Global Testosterone Replacement Therapy Revenue Forecast by Type (2021-2026)4.2.4 Testosterone Replacement Therapy Price Forecast by Type (2021-2026) 5 Global Testosterone Replacement Therapy Market Size by Application5.1 Global Testosterone Replacement Therapy Historic Market Review by Application (2015-2020)5.1.2 Global Testosterone Replacement Therapy Sales Market Share by Application (2015-2020)5.1.3 Global Testosterone Replacement Therapy Revenue Market Share by Application (2015-2020)5.1.4 Testosterone Replacement Therapy Price by Application (2015-2020)5.2 Global Testosterone Replacement Therapy Market Estimates and Forecasts by Application (2021-2026)5.2.2 Global Testosterone Replacement Therapy Sales Forecast by Application (2021-2026)5.2.3 Global Testosterone Replacement Therapy Revenue Forecast by Application (2021-2026)5.2.4 Testosterone Replacement Therapy Price Forecast by Application (2021-2026) 6 North America6.1 North America Testosterone Replacement Therapy Breakdown Data by Company6.2 North America Testosterone Replacement Therapy Breakdown Data by Type6.3 North America Testosterone Replacement Therapy Breakdown Data by Application6.4 North America Testosterone Replacement Therapy Breakdown Data by Countries6.4.1 North America Testosterone Replacement Therapy Sales by Countries6.4.2 North America Testosterone Replacement Therapy Revenue by Countries6.4.3 U.S.6.4.4 Canada 7 Europe7.1 Europe Testosterone Replacement Therapy Breakdown Data by Company7.2 Europe Testosterone Replacement Therapy Breakdown Data by Type7.3 Europe Testosterone Replacement Therapy Breakdown Data by Application7.4 Europe Testosterone Replacement Therapy Breakdown Data by Countries7.4.1 Europe Testosterone Replacement Therapy Sales by Countries7.4.2 Europe Testosterone Replacement Therapy Revenue by Countries7.4.3 Germany7.4.4 France7.4.5 U.K.7.4.6 Italy7.4.7 Russia 8 Asia Pacific8.1 Asia Pacific Testosterone Replacement Therapy Breakdown Data by Company8.2 Asia Pacific Testosterone Replacement Therapy Breakdown Data by Type8.3 Asia Pacific Testosterone Replacement Therapy Breakdown Data by Application8.4 Asia Pacific Testosterone Replacement Therapy Breakdown Data by Regions8.4.1 Asia Pacific Testosterone Replacement Therapy Sales by Regions8.4.2 Asia Pacific Testosterone Replacement Therapy Revenue by Regions8.4.3 China8.4.4 Japan8.4.5 South Korea8.4.6 India8.4.7 Australia8.4.8 Taiwan8.4.9 Indonesia8.4.10 Thailand8.4.11 Malaysia8.4.12 Philippines8.4.13 Vietnam 9 Latin America9.1 Latin America Testosterone Replacement Therapy Breakdown Data by Company9.2 Latin America Testosterone Replacement Therapy Breakdown Data by Type9.3 Latin America Testosterone Replacement Therapy Breakdown Data by Application9.4 Latin America Testosterone Replacement Therapy Breakdown Data by Countries9.4.1 Latin America Testosterone Replacement Therapy Sales by Countries9.4.2 Latin America Testosterone Replacement Therapy Revenue by Countries9.4.3 Mexico9.4.4 Brazil9.4.5 Argentina 10 Middle East and Africa10.1 Middle East and Africa Testosterone Replacement Therapy Breakdown Data by Type10.2 Middle East and Africa Testosterone Replacement Therapy Breakdown Data by Application10.3 Middle East and Africa Testosterone Replacement Therapy Breakdown Data by Countries10.3.1 Middle East and Africa Testosterone Replacement Therapy Sales by Countries10.3.2 Middle East and Africa Testosterone Replacement Therapy Revenue by Countries10.3.3 Turkey10.3.4 Saudi Arabia10.3.5 U.A.E 11 Company Profiles11.1 AbbVie11.1.1 AbbVie Corporation Information11.1.2 AbbVie Business Overview and Total Revenue (2019 VS 2018)11.1.3 AbbVie Testosterone Replacement Therapy Sales, Revenue, Average Selling Price (ASP) and Gross Margin (2015-2020)11.1.4 AbbVie Testosterone Replacement Therapy Products and Services11.1.5 AbbVie SWOT Analysis11.1.6 AbbVie Recent Developments11.2 Endo International11.2.1 Endo International Corporation Information11.2.2 Endo International Business Overview and Total Revenue (2019 VS 2018)11.2.3 Endo International Testosterone Replacement Therapy Sales, Revenue, Average Selling Price (ASP) and Gross Margin (2015-2020)11.2.4 Endo International Testosterone Replacement Therapy Products and Services11.2.5 Endo International SWOT Analysis11.2.6 Endo International Recent Developments11.3 Eli lilly11.3.1 Eli lilly Corporation Information11.3.2 Eli lilly Business Overview and Total Revenue (2019 VS 2018)11.3.3 Eli lilly Testosterone Replacement Therapy Sales, Revenue, Average Selling Price (ASP) and Gross Margin (2015-2020)11.3.4 Eli lilly Testosterone Replacement Therapy Products and Services11.3.5 Eli lilly SWOT Analysis11.3.6 Eli lilly Recent Developments11.4 Pfizer11.4.1 Pfizer Corporation Information11.4.2 Pfizer Business Overview and Total Revenue (2019 VS 2018)11.4.3 Pfizer Testosterone Replacement Therapy Sales, Revenue, Average Selling Price (ASP) and Gross Margin (2015-2020)11.4.4 Pfizer Testosterone Replacement Therapy Products and Services11.4.5 Pfizer SWOT Analysis11.4.6 Pfizer Recent Developments11.5 Actavis (Allergan)11.5.1 Actavis (Allergan) Corporation Information11.5.2 Actavis (Allergan) Business Overview and Total Revenue (2019 VS 2018)11.5.3 Actavis (Allergan) Testosterone Replacement Therapy Sales, Revenue, Average Selling Price (ASP) and Gross Margin (2015-2020)11.5.4 Actavis (Allergan) Testosterone Replacement Therapy Products and Services11.5.5 Actavis (Allergan) SWOT Analysis11.5.6 Actavis (Allergan) Recent Developments11.6 Bayer11.6.1 Bayer Corporation Information11.6.2 Bayer Business Overview and Total Revenue (2019 VS 2018)11.6.3 Bayer Testosterone Replacement Therapy Sales, Revenue, Average Selling Price (ASP) and Gross Margin (2015-2020)11.6.4 Bayer Testosterone Replacement Therapy Products and Services11.6.5 Bayer SWOT Analysis11.6.6 Bayer Recent Developments11.7 Novartis11.7.1 Novartis Corporation Information11.7.2 Novartis Business Overview and Total Revenue (2019 VS 2018)11.7.3 Novartis Testosterone Replacement Therapy Sales, Revenue, Average Selling Price (ASP) and Gross Margin (2015-2020)11.7.4 Novartis Testosterone Replacement Therapy Products and Services11.7.5 Novartis SWOT Analysis11.7.6 Novartis Recent Developments11.8 Teva11.8.1 Teva Corporation Information11.8.2 Teva Business Overview and Total Revenue (2019 VS 2018)11.8.3 Teva Testosterone Replacement Therapy Sales, Revenue, Average Selling Price (ASP) and Gross Margin (2015-2020)11.8.4 Teva Testosterone Replacement Therapy Products and Services11.8.5 Teva SWOT Analysis11.8.6 Teva Recent Developments11.9 Mylan11.9.1 Mylan Corporation Information11.9.2 Mylan Business Overview and Total Revenue (2019 VS 2018)11.9.3 Mylan Testosterone Replacement Therapy Sales, Revenue, Average Selling Price (ASP) and Gross Margin (2015-2020)11.9.4 Mylan Testosterone Replacement Therapy Products and Services11.9.5 Mylan SWOT Analysis11.9.6 Mylan Recent Developments11.10 Upsher-Smith11.10.1 Upsher-Smith Corporation Information11.10.2 Upsher-Smith Business Overview and Total Revenue (2019 VS 2018)11.10.3 Upsher-Smith Testosterone Replacement Therapy Sales, Revenue, Average Selling Price (ASP) and Gross Margin (2015-2020)11.10.4 Upsher-Smith Testosterone Replacement Therapy Products and Services11.10.5 Upsher-Smith SWOT Analysis11.10.6 Upsher-Smith Recent Developments11.11 Ferring Pharmaceuticals11.11.1 Ferring Pharmaceuticals Corporation Information11.11.2 Ferring Pharmaceuticals Business Overview and Total Revenue (2019 VS 2018)11.11.3 Ferring Pharmaceuticals Testosterone Replacement Therapy Sales, Revenue, Average Selling Price (ASP) and Gross Margin (2015-2020)11.11.4 Ferring Pharmaceuticals Testosterone Replacement Therapy Products and Services11.11.5 Ferring Pharmaceuticals SWOT Analysis11.11.6 Ferring Pharmaceuticals Recent Developments11.12 Kyowa Kirin11.12.1 Kyowa Kirin Corporation Information11.12.2 Kyowa Kirin Business Overview and Total Revenue (2019 VS 2018)11.12.3 Kyowa Kirin Testosterone Replacement Therapy Sales, Revenue, Average Selling Price (ASP) and Gross Margin (2015-2020)11.12.4 Kyowa Kirin Testosterone Replacement Therapy Products and Services11.12.5 Kyowa Kirin SWOT Analysis11.12.6 Kyowa Kirin Recent Developments11.13 Acerus Pharmaceuticals11.13.1 Acerus Pharmaceuticals Corporation Information11.13.2 Acerus Pharmaceuticals Business Overview and Total Revenue (2019 VS 2018)11.13.3 Acerus Pharmaceuticals Testosterone Replacement Therapy Sales, Revenue, Average Selling Price (ASP) and Gross Margin (2015-2020)11.13.4 Acerus Pharmaceuticals Testosterone Replacement Therapy Products and Services11.13.5 Acerus Pharmaceuticals SWOT Analysis11.13.6 Acerus Pharmaceuticals Recent Developments 12 Supply Chain and Sales Channels Analysis 12.1 Supply Chain Analysis 12.2 Sales Channels Analysis12.2.1 Testosterone Replacement Therapy Sales Channels12.2.2 Testosterone Replacement Therapy Distributors12.3 Testosterone Replacement Therapy Customers 13 Estimates and Projections by Regions (2021-2026)13.1 Global Testosterone Replacement Therapy Sales Forecast (2021-2026)13.1.1 Global Testosterone Replacement Therapy Sales Forecast by Regions (2021-2026)13.1.2 Global Testosterone Replacement Therapy Revenue Forecast by Regions (2021-2026) 13.2 North America Market Size Forecast (2021-2026)13.2.1 North America Testosterone Replacement Therapy Sales Forecast (2021-2026)13.2.2 North America Testosterone Replacement Therapy Revenue Forecast (2021-2026)13.2.3 North America Testosterone Replacement Therapy Size Forecast by County (2021-2026) 13.3 Europe Market Size Forecast (2021-2026)13.3.1 Europe Testosterone Replacement Therapy Sales Forecast (2021-2026)13.3.2 Europe Testosterone Replacement Therapy Revenue Forecast (2021-2026)13.3.3 Europe Testosterone Replacement Therapy Size Forecast by County (2021-2026) 13.4 Asia Pacific Market Size Forecast (2021-2026)13.4.1 Asia Pacific Testosterone Replacement Therapy Sales Forecast (2021-2026)13.4.2 Asia Pacific Testosterone Replacement Therapy Revenue Forecast (2021-2026)13.4.3 Asia Pacific Testosterone Replacement Therapy Size Forecast by Region (2021-2026) 13.5 Latin America Market Size Forecast (2021-2026)13.5.1 Latin America Testosterone Replacement Therapy Sales Forecast (2021-2026)13.5.2 Latin America Testosterone Replacement Therapy Revenue Forecast (2021-2026)13.5.3 Latin America Testosterone Replacement Therapy Size Forecast by County (2021-2026) 13.6 Middle East and Africa Market Forecast13.6.1 Middle East and Africa Testosterone Replacement Therapy Sales Forecast (2021-2026)13.6.2 Middle East and Africa Testosterone Replacement Therapy Revenue Forecast (2021-2026)13.6.3 Middle East and Africa Testosterone Replacement Therapy Size Forecast by County (2021-2026) 14 Research Findings and Conclusion 15 Appendix15.1 Research Methodology15.1.1 Methodology/Research Approach15.1.2 Data Source15.2 Author Details15.3 Disclaimer

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Testosterone Replacement Therapy Market Overview, Development History And Forecast To Shared In Latest Research Report 2020-2026 |Endo International,...

When it comes to bodybuilders, athletes, or fitness junkies looking to get the edge with their gains, taking growth hormone (GH) is a highly sought after option. Growth hormone is a peptide hormone used to stimulate growth, cell reproduction and regeneration, and is vital for human development. Getting that shredded physique is something we all seek and when done right, big gains comes from growth hormone use. It is when its abused that things start to go awry.

We sat down with Dr. Testosterone to discuss growth hormone and the short term and long term effects of using it. How it works, why its prescribed, and the role it plays with acne are all key questions Dr. Testosterone addressed for us. We even took on the challenge of asking him whether conventional steroids or selective androgen receptor modulators (SARMs) were more effective for bodybuilding.

Dr. Testosterone is one a small selection of certified doctors whose mission is to improve the health and safety of bodybuilders. As someone who understands the laws and regulation surrounding steroid and PED use, he does his best to educate bodybuilders on the safest ways to enhance their overall physique and performance while staying the most safe. In our latest GI Exclusive interview, Dr. Testosterone talks about the truth surrounding growth hormone and the effects abuse can have on the body.

Growth hormone is a peptide hormone used to stimulate growth, cell reproduction and regeneration, and is used as anabolic agent for performance enhancements. It is prescribed for those with Dwarfism, Turner Syndrome, HIV/AIDS patients who suffered from muscle wasting, and recovery and recuperation post-surgery (1).

How growth hormone works is that all organs have receptors or Insulin-like growth factor 1 (IGF-1) and when released, it works as a fat burner and can aid in cell recovery and recuperation. When we fast, we burn through growth hormone. Once it exceeds a certain limit, then we start to see skeletal muscle growth and visceral muscle growth, but also the negative effects.

In the short term, negative side effects of abused growth hormone include carpal tunnel syndrome and a pre-diabetic state. Growth hormone is responsible for the swelling which causes compression of your wrist tendons that pinch your medial nerve. Surgery is required to release this tension (2). Since GH liberates glucose from your liver into the blood stream, glycemia can occur. With little cardio and an elevated glycemic state, this can lead to Type 2 diabetes which is often why people take Insulin along with growth hormone as a regulator.

In the long term, while abuse may come with muscle growth, you are at an added risk of more severe side effects. Enlarged organs become a serious risk as a result of organomegaly and cardiomegaly. Enlarged jaw, cheekbones, forehead and other internal organs become enlarged and your heart can seriously increase in size causing its own series of side effects. Thicker skin, enlarged nose, lips, and tongue, and potential tumor growth if predisposed are all other effects that may come from GH abuse.

When taking steroids, many report increased acne which can cause pain but can also just be uncomfortable and hurt your confidence. Since acne effects everyone at different times and is very common, there are many ways to treat acne, some naturally and others may require a doctor. Acne is a result of dihydrotestosterone (DHT) which is an androgen metabolite of testosterone (3). DHT stimulates the production of oil that leads to clogged glands and pores and often times these are unable to release oil leading to inflammation. Steroids metabolize to estrogen in the body and then to DHT causing all of the above.

Anti-androgens are one way to treat this but they may block DHT and you may feel the effects of low sex drive and depression. Other creams or antibiotics, purified alcohol, or UV light can also help. Diet is a key natural way to reduce acne and eating clean goes a long way. Avoiding trans or saturated fat is big, but consuming unsaturated fatty acids like fish oil can be very beneficial. Sugar causes inflammation through Insulin so removing as much sugar from your diet as you can is also a big bonus (4).

While this may be a matter of opinion, Dr. Testosterone is a trusted voice when it comes to something like this topic. To start, selective androgen receptor modulators (SARMs) are a new kind of androgenic drug claiming to have more uses than your conventional steroids (5). The issue with many people is that this is still new and regulated like conventional steroids. Still with a gray area surrounding this treatment, many are suspicious without further evidence to back up claims that they have the same effects as anabolic steroids, but could be faked with other things that arent regulated.

For Dr. Testosterone, he feels comfortable with conventional steroids because theyve been around for a very long time, amassing ample evidence as to their ability to work properly. Instead of going to the new kid on the block, we use pharmaceutical grade, legitimate steroids where we know of the side effects and proper dosages.

Dr. Testosterone enlightened us with new and valuable information about growth hormones and the negative effects that come with too much. While trying to get to the next level is something we should all strive for, knowing how to safely and effectively do so is incredibly important. As someone who understands the science and the law behind these drugs, Dr. Testosterone is a great source of knowledge for all of us looking for that valuable information. Check out this GI Exclusive to learn more about growth hormone, the negative effects, and other aspects of health and safety to know when looking into something like this.

Let us know what you think in the comments below.Also, be sure to follow Generation Iron onFacebook, Twitter, andInstagram.

*Images courtesy of Envato

References

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Growth Hormones Vs Steroids Vs SARMs: Everything You Need To Know | Dr. Testosterone - generationiron.com

A MAN who made a documentary about his first year on testosterone during his transition has won a national filmmakingaward.

Ben Hodge, from Rainhill, faced difficulty and bullying after coming out as trans.

However last year, as he started transitioning, he filmed his journey in a documentary called 1 year: A letter to my 14 year old self.

The film shows the highs and lows of Ben finding himself and thoughts throughout the process.

His film has now been shortlisted for the Best Documentary Category of the Into Film Awards sponsored by The National Lottery.

The Into Film Awards were due to take place on March 18 at Londons ODEON Luxe Leicester Square, however due to coronavirus it took place online and was hosted by David Walliams OBE.

Ben, 20, took the Best Documentary prize for his film.

He said: "I can't believe that my film which started out as an idea for a Facebook post has made it this far. It's truly an honour.

"Something I think that is important to note is that no two LGBT+ experiences are the same.

"But I hope that by sharing my experiences, I can open some level of understanding and tolerance in my audience.

Bens film sees him writing a letter to his younger self about the myriad of ways his life has improved in the last five years, and also charts his first year on testosterone as he transitions to becoming the person he truly is.

Ben is currently studying Media & Performance at the University of Salford and is an amateur filmmaker and theatre creator with a particular interest in stories regarding LGBTQ+ experiences.

Ben before his transition

He also has an interest in stand-up comedy, drawing on his experiences as an openly gay transgender man to make light of things that otherwise might not be discussed.

This has taken him around the country, from Manchester all the way to the Edinburgh Fringe.

1 Year has been screened across the globe, from a UNICEF talk about youth filmmaking and creating empathy in Kathmandu, Nepal to the Geelong Pride Film Festival in Australia and a current LGBT+ History Month exhibition at the University of Salford.

Ben is currently making a film about St Helens and how the closing of the mining industry affected the town and culture.

He wants to screen the final product in a community cinema.

The Into Film Awards celebrate exceptional talent from children and young people aged 5 19 years old who have demonstrated impressive achievements in filmmaking and film reviewing.

Host for the 2020 Awards, David Walliams said: I love the Into Film Awards because it gives the opportunity to young people, from all kinds of backgrounds, to be a part of the film industry.

"As an actor, these young people are the future, and you want them to give you a job one day!

"Anything that encourages creativity is important, we have an amazing film industry in this country which is often ignored by politicians and we need to support it.

"Into Film is an amazing charity."

For more information intofilm.org/Awards

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Student from Rainhill honoured at The Into Film Awards - St Helens Star

Final Report will add the analysis of the impact of COVID-19 on this industry.

November 2020:

The global Testosterone Replacement Therapy Market research report offers all the vital data in the domain. The latest report assists new bees as well as established market participants to analyze and predict the Testosterone Replacement Therapy market at the regional as well as global level. It covers the volume [k MT] as well as revenues [USD Million] of the global Testosterone Replacement Therapy market for the estimated period. Numerous key players AbbVie, Inc., Bayer AG, Endo Pharmaceuticals, Inc., Eli Lilly and Company, Kyowa Kirin International plc, Pfizer, Inc., Acerus Pharmaceuticals Corporation, and Perrigo Company plc. are dominating the global Testosterone Replacement Therapy market. These players hold the majority of share of the global Testosterone Replacement Therapy market.

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The data presented in the global Testosterone Replacement Therapy market offers budding opportunities, which help users to make strategic moves and prosper their business. The report highlights the impact of numerous factors that might result in obstructing or propelling the Testosterone Replacement Therapy market at global as well as local level. The global Testosterone Replacement Therapy market research report offers the summary of key players dominating the market including several aspects such as their financial summary, business strategy, and most recent developments in these firms.

Detailed Segmentation:

By Active Ingredient TypeTestosteroneMethyl TestosteroneTestosterone UndecanoateTestosterone EnanthateTestosterone CypionateBy Route of AdministrationInjectablesParenteral

By Region

North America (U.S., Canada, Mexico)

Asia Pacific (India, China, Japan, South Korea, ASEAN, Rest of Asia Pacific)

Europe (Italy, Germany, France, Spain, Central & Eastern Europe, Rest of Europe)

Middle East & Africa (GCC, Turkey, Rest of the Middle East & Africa)

South America (Brazil, Argentina, Rest of South America)

The study encompasses profiles of major companies operating in the Testosterone Replacement Therapy Market. Key players profiled in the report includes: AbbVie, Inc., Bayer AG, Endo Pharmaceuticals, Inc., Eli Lilly and Company, Kyowa Kirin International plc, Pfizer, Inc., Acerus Pharmaceuticals Corporation, and Perrigo Company plc.

Key points of the global Testosterone Replacement Therapy market

The oretical analysis of the global Testosterone Replacement Therapy market stimulators, products, and other vital facets

Recent, historical, and future trends in terms of revenue and market dynamics are reported

Pin-point analysis of the competitive market dynamics and investment structure is predicted to grow

Future market trends, latest innovations, and various business strategies are reported

Market dynamics include growth influencers, opportunities, threats, challenges, and other crucial facets

The global Testosterone Replacement Therapy market research report offers users with an all-inclusive package of market analysis that includes current market size, expansion rate, and value chain analysis. The global Testosterone Replacement Therapy market is segmented on a regional basis Europe, North America, Latin America, Asia Pacific, and Middle East & Africa as well. To offer a comprehensive view and competitive outlook of the global Testosterone Replacement Therapy market, our review team employs numerous methodological procedures, for instance, Porters five forces analysis.

This research report includes the analysis of various Testosterone Replacement Therapy market segments. The bifurcation of the global market is done based on its present and prospective inclinations. The regional bifurcation involves the present market scenario in the region along with the future projection of the global Testosterone Replacement Therapy market. The global market report offers an overview of expected market conditions due to changes in the technological, topographical, and economic elements.

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Increase in the Adoption of Testosterone Replacement Therapy to Propel the Growth of the Testosterone Replacement Therapy Market Between 2020-2027 -...

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