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Editor's note: This article is not medical advice. Consult a healthcare professional regarding questions about diagnoses and treatment.

I started hormone replacement therapy in April, the same day Arkansas passed the first trans medical ban in the United States, barring trans youth from accessing gender-affirming care.

With the heaviness of the wave of anti-trans legislation on my mind, I felt fortunate to have access to an endocrinologist after nearly a year of back-and-forth with insurance and several attempts with less trans-competent doctors.

I wanted to start testosterone-based HRT to treat my lifelong gender dysphoria, or extreme distress related to my body and gender, that has affected me as a transmasculine nonbinary person. I started testosterone therapy to deepen my voice, make myself a little more muscular, and overall become more comfortable in my body.

As someone who has insurance that covers gender-affirming care and lives in a major city, I am incredibly privileged.

I microdose HRT, meaning I take a smaller amount of testosterone for more gradual changes over a longer period of time. When I told my endocrinologist in New York City that I wanted to stay on a microdose long-term, he said he could write me the prescription but had to be transparent about the lack of research available on it. When I asked him what changes I could expect for my body, he told me he didn't know, even after I pressed for more information.

The only place I've been able to turn to for concrete answers on how to achieve the results I wanted like a deeper voice and larger muscles was online platforms like Reddit.

Hormone replacement therapy as a form of treatment for the gender dysphoria that trans people experience has been around since the 1920s. But treatment protocols have been slow to shift.

Because of a lack of research on the effects of different HRT options, even trans-competent medical providers are left with few concrete studies to cite when patients ask questions, and physicians receive few hours of LGBTQ+-specific training.

One of the first questions I asked my doctor was which kind of injection I should opt for to get the most dramatic effects, which for me included a deeper voice, more muscle definition, and fat redistribution.

While small studies have suggested that subcutaneous injections (injection into the fat) could help retain testosterone in the body for longer between shots, my doctor told me there wasn't enough conclusive data to confirm this. I ended up opting for intramuscular injections and was dissatisfied with how long it took to see physical changes.

In the first month of taking HRT, the skin around my jaw thickened. When I went back to the doctor and asked how long it would take for my jawline to reemerge, he told me there wasn't enough research out there for him to give me a timeline.

Puffy-faced and feeling lost, I turned to the internet for understanding.

My friends who had started HRT before me recommended going on Reddit to find specific answers about where I should inject my T for the most effective results.

There I found several subreddits, like r/FTM and r/genderqueer, where people shared similar concerns and got their questions answered by a community of trans people who had taken testosterone. That's how I found out about the small study suggesting subcutaneous injections could keep testosterone in your system longer than intramuscular injections. So I switched, and I am much happier with the results.

My only sense of understanding about my body during this process came from other trans people willing to share their experiences with HRT.

Even close friends who have been on testosterone have been more helpful in some ways to my transition than my doctor.

One of my friends has a more radical endocrinologist willing to talk about experimental treatments that have anecdotally worked on patients, so I often chat with them about what they've learned so I can take questions back to my own doctor. My other friend lives on the internet and can name trans subreddits at the drop of a hat, so they offer their knowledge.

My friends and I doctor one another in many ways, trading information like playing cards.

Trans Reddit forums became a haven of support for me when so many of my medical concerns went unanswered through official channels. While I can only take the experiences of others with a grain of salt, they have been a huge comfort during a nerve-wracking process.

Read more:
I'm trans and take testosterone. Reddit helps more than my doctor. - Insider

Statins are known to help keep cholesterol levels healthy further reducing the risk of heart attacks or strokes. As with most things, there are side effects which one needs to be aware of. Erectile dysfunction and lowered testosterone are some of the side effects reported. What is the link?

Statins are commonly prescribed to help lower cholesterol however, the drug also appears to lower testosterone.

According to a study which evaluated nearly 3,500 men who had erectile dysfunction, the drug could be the cause.

"Current statin therapy is associated with a twofold increased prevalence of hypogonadism a condition in which men don't produce enough testosterone, said Dr Giovanni Corona, lead study author and researcher at the University of Florence, Italy.

He added: "Our study is the first report showing a negative association between statin therapy and testosterone levels in a large series of patients consulting for sexual dysfunction.

READ MORE:Pfizer booster vaccine side effects: Five of the most common symptoms after the third jab

Dr Corona and colleagues evaluated 3,484 men, average age 51, who visited an outpatient clinic at the University of Florence with complaints of sexual dysfunction between January 2002 and August 2009.

Of that total, 244 (or seven percent) were being treated with statins for their high cholesterol.

The researchers calculated the men's total testosterone as well as free testosterone, and the amount of unbound testosterone in the bloodstream.

When they compared men on statins to those not, the men on statins were twice as likely to have low testosterone regardless of which of the three commonly used thresholds for low testosterone they looked at.

DON'T MISSHigh cholesterol: Three signs on your foot[INSIGHT]Type 2 diabetes: The cheap snack to lower blood sugar[ADVICE]Statins: The 90p drink that makes drug 'toxic'[TIPS]

Another study published in Oxford Academic investigated the lipid-lowering drug and its possible link to erectile dysfunction.

A systematic review was carried out using computerised biomedical databases and internet sources relating to erectile dysfunction and statins.

A significant literature was identified, much from obscure sources, which included case reports, review articles, and information from clinical trials and from regulatory agencies, noted the study.

It added: A substantial number of cases of erectile dysfunction associated with statin usage have been reported to regulatory agencies.

While erectile dysfunction isnt a widely reported side effect of statins, researchers have explored the possibility.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine you're taking.

It's run by a medicines safety watchdog called the Medicines and Healthcare products Regulatory Agency (MHRA).

The purpose of the scheme is to provide an early warning that the safety of a medicine or a medical device may require further investigation.

Side effects reported on Yellow Cards are evaluated, together with additional sources of information such as clinical trial data.

Excerpt from:
Statins side effects: The worrisome sexual symptom men need to be aware of - Express

Nov 6th 2021

WASHINGTON, DC

CAROL HAD long suspected her everyday life in rural California would be easier if she were a man. Yet she was stunned by how true this turned out to be. As a butch woman (and not a big smiler) she was routinely treated with slight contempt, she says. After a double mastectomy and a few months on testosteronewhich gave her facial hair and a gravelly voicepeople, cashiers, everyone, suddenly became so goddam friendly.

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Yet Carol soon felt wretched as a trans man. At first, the testosterone she started injecting at 34 lifted her mood and energy levels. But after two years she began to suffer awful side effects. Vaginal and uterine atrophy (which can cause tissue to crack and bleed) was extremely painful. Her cholesterol levels rose and she had palpitations. She also became so anxious she started having panic attacks.

So she went on antidepressants, and they worked. It was a light-bulb moment, she says. I was like, I needed the antidepressants; I didnt need to transition. She realised her gender dysphoria, the painful feeling she was in the wrong body, did not, in fact, make her a man.

Nearly three years ago, after four years as a trans man, Carol became a detransitioner: someone who has taken cross-sex hormones or had surgery, or both, before realising this was a mistake. Her experience illustrates the dangers of a gender-affirmative model of care that accepts patients self-diagnosis that they are trans, now standard practice in Americas transgender medicine field.

No one knows how many detransitioners there are, but anecdotal evidence, and swelling memberships of online groups, suggests the number is growing fast. A recent survey of 100 detransitioners (69 of whom were female) by Lisa Littman, a doctor and researcher, found a majority felt that they had not received an adequate evaluation before treatment. Nearly a quarter said homophobia or difficulty accepting that they were gay had led them to transition; 38% reckoned their gender dysphoria was caused by trauma, abuse or a mental-health condition.

Carol believes the roots of her gender dysphoria lay in her childhood. An upbringing that was both fanatically religious and abusive rammed home two harmful messages. One was the importance of rigid gender roleswomen were there to serve; they were less than men. Her mothers endless fury that Carol would not bow to this notion of womanhood, which included wearing only dresses (I didnt even walk like a girl, whatever that meant) meant she grew up believing her way of being female was somehow all wrong. The other message was that homosexuality was an abomination.

Carols oh God moment came, as she amusingly describes, when she developed a heavy crush on her mothers female estate agent at 16. The realisation prompted a breakdown (though she didnt call it that at the time). First she fasted and prayed to God to take this away. Then she began drinking heavily and having one-night stands with men in the hope something would click. When she came out at the age of 20, many of her relatives excluded her from family gatherings.

It was in her early 20s, when many lesbians in her social circle (almost always the butch ones) started identifying as trans men that she began to think, This must be it! This is what is wrong with me! But she was told she had to live as a man for six months before being approved for treatment and the thought of using the mens toilet was intolerable. By this point, she had met the woman who would become her wife and found some stability.

But she was still deeply unhappy. I just feltwrong, she says. I was disgusted with myself, and if a nice answer comes along and says, this is going to fix it, guess what youre going to do? By her mid-30s, she no longer needed to see a therapist to be prescribed testosterone. (Planned Parenthood uses an informed consent model in 35 states, meaning trans patients do not need a therapists note.) Yet Carol did see a therapist, because she wanted to do it right. The therapist did not explore her childhood trauma, but encouraged her to try testosterone. Months later Carol had her breasts removed.

Detransitioning was the hardest thing she has done, she says. She was so terrified and ashamed that it took a year to come off testosterone. To her relief her cholesterol levels returned to normal in months. She still has some facial hair and a deep voice. Her mastectomy is like any loss: it dissipates but it never completely goes away.

She now spends a lot of time campaigning for other detransitioners stories to be heard. This is not easy work. Outspoken detransitioners are often maligned. One gender-medicine doctor has criticised the use of the term detransitioner, saying, with extraordinary cruelty, it doesnt really mean anything. Dr Littmans study found that only 24% of detransitioners told their doctors transitioning had not worked out. This may help explain why some dismiss the phenomenon.

Carol worries about girls who are taking puberty blockers to avoid becoming women, something she says she would have leapt at given the chance. And she worries about butch lesbians who are being encouraged to consider that they are in fact straight men. She now considers this homophobic. My wife told me recently that when I was transitioning she was on board for two months before realising, this is crazy. And she was right. She was being told, your wife is really a man so you are bisexual or straight. It was bullshit.

This article appeared in the United States section of the print edition under the headline "Portrait of a detransitioner"

See original here:
Portrait of a detransitioner as a young woman - The Economist

GLITZ LIFESTYLE

Experts link womens longevity streak to lifestyle, situating men at a higher risk of contracting chronic illnesses. Martins Ifijeh writes

This gender gap in life expectancy is true for all societies, and it is also true for the great apes, said Perminder Sachdev, a doctor and professor of neuropsychiatry at the University of New South Wales in Australia who has studied human longevity.Sachdev, according to TheCable, also spoke of the main health issues that are contributing to why women tend to outlive men.

Men are more likely to smoke, drink excessively and be overweight, he said. They are also less likely to seek medical help early, and, if diagnosed with a disease, they are more likely to be non-adherent to treatment.As you go through some of the common health threats to men, and how to avoid them, also know that early diagnosis should be a top priority in healthcare for men.

Prostate CancerProstate cancer is common among men. Although many consider it reserved for the older population, it can occur in younger men as well.It is treatable if found in its early stages but often shows no symptom until it spreads to other parts of the body. Going for regular checkups, having a healthy diet, and exercising more often are some key healthcare tips to fend off the disease.

Heart DiseaseAccording to a report, one in 10 men aged 50 has a heart age 10 years older than they are. Imagine that!Heart disease mortality is also said to be higher in men.Ways to keep this disease at bay are by avoiding smoking and alcohol, adopting diets low in saturated fats, avoiding highly processed food. You should also embrace weight loss and physical exercise. But again, regular checkups are a must.

StrokeA stroke occurs when the blood supply to part of your brain is interrupted or reduced, preventing brain tissue from getting oxygen and nutrients. Brain cells begin to die in minutes.A stroke is a medical emergency, and prompt treatment is crucial. Early action can reduce brain damage and other complications.There are three main types of stroke: Ischemic stroke, Hemorrhagic stroke and Transient ischemic attack (a warning or mini-stroke).The signs of stroke are: sudden numbness or weakness in the face, arm, or leg, especially on one side of the body; sudden confusion, trouble speaking, or difficulty understanding speech; sudden trouble seeing in one or both eyes; and sudden trouble walking, dizziness, loss of balance, or lack of coordination.The good news is that many fewer Americans die of stroke now than in the past. Effective treatments can also help prevent disability from stroke.

DepressionResearch has shown that, although both men and women suffer depression, men are less likely than women to recognize, talk about, and seek treatment for the same.The reluctance among men may be due to societal constructs which expect them to be strong.If youre a man struggling with depression, try regular exercise, journaling, communicating openly with friends and family, and seeking professional help.

High Blood PressureWhile common among both sexes, high blood pressure is more prevalent in men. Its not inevitable and can be prevented, delayed, and treated.If ignored, it can lead to heart and kidney failure, vision problems, and even blindness. Stress, lack of physical activity, and being overweight or obese increase the odds, as do genetics.Can you see the need for regular medical checkups now?

Skin CancerBy age 50, men are also more likely than women to develop melanoma, a form of skin cancer.This number jumps by age 65, making men 2 times as likely as women of the same age to get melanoma. This higher risk is likely related to more frequent sun exposure and fewer visits to the doctor.Men are also more likely to die from the disease.

Erectile DysfunctionA common health problem, especially for men with diabetes or prostate issues, is erectile dysfunction.Erectile dysfunction is most often caused by atherosclerosis the same process that causes heart attacks and strokes. There are a number of reasons why men develop erectile dysfunction, many of which can be treated.Its important to see a doctor so that they can rule out or treat any underlying medical conditions.

Testosterone DeficiencyTestosterone is the male sex hormone that is made in the testicles. Testosterone hormone levels are important to normal male sexual development and functions.Some men have low testosterone levels which could be called Testosterone Deficiency Syndrome (TD) or Low Testosterone (Low-T). Deficiency means that the body does not have enough of a needed substance.According to the American Urological Association, at least two out of 10 men older than 60 years have low testosterone.Experts believe that a healthy lifestyle such as weight loss and getting more physical activity will likely raise your testosterone levels.

Lung CancerLung cancer is the leading cause of cancer deaths in men. Cigarette smoking is the number one risk factor for lung cancer. According to the American Lung Association, each year more men are diagnosed with and develop lung cancer than in years past. Quitting smoking at any age can lower the risk of lung cancer.

Alcohol DeathsConsuming too much alcohol is dangerous for ones health as it increases your risk for cancer of the mouth, throat, esophagus, liver, and colon.But according to the Centers for Disease Control and Prevention (CDC), men face higher rates of alcohol-related deaths and hospitalizations than women do. Men take in twice as much as women and are more likely to increased aggression and sexual assault against women. Avoid taking alcohol.

DiabetesDiabetes is a chronic and metabolic disease that can lead to nerve and kidney damage, heart disease and stroke, and even vision problems or blindness if left untreated.A study found that men are almost twice as likely to develop type 2 diabetes than women. Engaging in exercise, combined with a healthy diet, can prevent diabetes. Bottom line is, see a doctor regularly gents!

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Erectile Dysfunction, Diabetes among 11 Common Health Threats to Men - THISDAY Newspapers

Researchers arent certain why the messenger RNA vaccines, one from Pfizer Inc. and partner BioNTech SE and the other from Moderna Inc., are likely causing the inflammatory heart conditions myocarditis and pericarditis in a small number of cases.

Some theories center on the type of spike protein that a person makes in response to the mRNA vaccines. The mRNA itself or other components of the vaccines, researchers say, could also be setting off certain inflammatory responses in some people.

One new theory under examination: improper injections of the vaccine directly into a vein, which sends the vaccine to heart muscle.

To find answers, some doctors and scientists are running tests in lab dishes and examining heart-tissue samples from people who developed myocarditis or pericarditis after getting vaccinated.

Myocarditis describes inflammation of the heart muscle, while pericarditis refers to inflammation of the sac surrounding the muscle.

Covid-19 itself can cause both conditions. They have also been reported in a smaller number of people who got an mRNA vaccine, most commonly in men under 30 years and adolescent males.

About 877 confirmed cases of myocarditis in vaccinated people under 30 years have been reported in the U.S., out of 86 million mRNA vaccine doses administered, according to the Centers for Disease Control and Prevention.

The risk is higher within seven days of the second dose of the Pfizer-BioNTech and Moderna vaccines, the Food and Drug Administration says. Most myocarditis cases in vaccinated people are relatively mild, and patients get better on their own or with minimal treatment, doctors say.

The CDC recommends that anyone 5 years and older should get vaccinated, saying the benefits of preventing Covid-19 illness, hospitalizations and death far outweigh the risk of myocarditis, even in younger males.

Researchers have been trying to understand the link between the cases and vaccination, as health authorities expand the vaccination campaign by recommending boosters and broadening use of the Pfizer-BioNTech vaccine to younger children.

The FDA has, however, held up authorizing use of the Moderna vaccine in adolescents while it investigates the risk

Some theories about the vaccines link to myocarditis center on the spike protein on the surface of the coronavirus.

The spike protein helps the virus gain entry into human cells to replicate. The mRNA vaccines are designed to cause the body to make a certain version of the spike protein, which then sets off an immune response.

The immune response includes neutralizing antibodies that target the spike protein and thereby block the viruss ability to get inside cells and replicate. The immune response can protect a person against Covid-19 or lessen its severity if someone is exposed to the virus.

Yet there may be similarities between the spike protein and proteins found in the heart muscle, prompting the bodys immune defenses to mobilize against the heart, according to Biykem Bozkurt, a professor of medicine specializing in cardiology at Baylor College of Medicine in Houston.

The antibodies against the spike protein may have the unintended effect of acting against heart proteins, said Dr. Bozkurt, who co-wrote a review of vaccine-associated myocarditis in the journal Circulation in July.

This molecular mimicry" theory hasnt been fully tested in vaccinated people and doesnt explain why myocarditis only occurs in certain people, she said.

Some of the mRNA in the vaccines may also be taken up by heart cells known as cardiomyocytes, said Jay Schneider, a consultant in cardiovascular medicine at the Mayo Clinics Jacksonville, Fla., campus.

These cells may then produce the spike protein of the coronavirus, which could draw an antibody response against them, Dr. Schneider said. He said he has conducted lab tests and found that heart cells have taken up the Moderna vaccine and then expressed the spike protein.

Dr. Schneider hasnt yet published results from these experiments in a peer-reviewed journal, and said they should be interpreted with caution.

Some doctors have theorized that improper injections of the vaccines may be contributing.

The shots are supposed to be injected into the shoulder muscle, also known as the deltoid muscle. If the injection accidentally reaches a vein, it could lead to delivery of some of the vaccine to the heart through blood vessels.

Hong Kong researchers found that injecting mice intravenously with the Pfizer-BioNTech vaccine induced both myocarditis and pericarditis in the animals, according to results published online in August by the journal Clinical Infectious Diseases.

That myocarditis appears to happen more among younger males after vaccination than in other age and sex groups suggests a link to the hormone testosterone, which is usually at high levels in younger males, according to researchers.

Testosterone may heighten an inflammatory immune response, Dr. Bozkurt said, leading to myocarditis in some male adolescents and young men.

Some studies have suggested that Modernas vaccine carries a higher risk of myocarditis than Pfizers. If this difference is confirmed, it could be related to differences in dose levels, Moderna Chief Executive Stphane Bancel said. Modernas vaccine contains more mRNA per dose than Pfizers.

Some vaccine specialists have cited the dose difference as one reason that the Moderna vaccines effectiveness against Covid-19 appears to hold up for longer than Pfizers.

Mr. Bancel said the benefit-risk ratio for Modernas vaccine is still favorable for younger males.

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Researchers probe link between Covid-19 vaccines and myocarditis - Livemint

Long-term testosterone therapy appears to improve erectile function and reduce mortality in men with hypogonadism and type 2 diabetes mellitus, according to a recent study presented at the 2021 Sexual Medicine Society of North America Fall Scientific Meeting.1

A total 361 men with hypogonadism (defined as total testosterone 350 ng/mL and at least moderate symptoms as assessed by the Aging Males Symptoms scale) in a single urology office had type 2 diabetes mellitus. Of these men, 183 received testosterone undecanoate injections of 1000 mg/12 weeks following an initial 6-week interval, with 178 patients opting to not receive TU injections serving as controls. International Index of Erectile Function-Erectile Function (IIEF-EF) domain score was assessed at each visit. Mortality was recorded based on reports from the patients general practitioners.

Changes over time between groups were compared by a mixed effects model for repeated measures with a random effect for intercept and fixed effects for time, group and their interaction and adjusted for age, weight, waist circumference, blood pressure, fasting glucose, lipids and quality of life to account for baseline differences between groups, wrote the authors, led by Farid Saad, MD, of Bayer AG and Gulf Medical University School of Medicine, Ajman, United Arab Emirates.

Mean follow-up was 8.23.2 years (median, 8 years) in the treatment group and 9.22.8 years (median, 10 years) in the control group. Total observation time was 1508 years in the treatment group vs 1641 years in the control group. Age at baseline was 60.75.5 years in the treatment group and 63.04.9 years for the controls (P < .0001). Phosphodiesterase 5 inhibitor usage at baseline was 27.3% in the treatment group vs 34.3% of the control group (P = .1527). At first visit, erectile dysfunction (ED) was reported by 64.5% of the treatment group vs 54.5% in the control group. In patients who did not report ED, the condition was diagnosed using the IIEF-EF in 30.6% of patients in the treatment group vs 44.4% in the control group, and 4.9% of patients in the treatment group and 1.1% in the control group had no ED.

Regarding erectile function, in year 12 for the treatment group, IIEF-EF increased by 12.10.4 (least squares means standard errors), whereas IIEF-EF decreased by 14.20.4 in the control group. Estimated adjusted difference between the 2 groups was 26.3.

Over the observation period, 15 patients (8.2%) in the treatment group died compared with 61 patients (34.3%) in the control group (P < .0001).

Our mortality data confirm the results by Hackett et al2,who observed the lowest mortality in a subgroup of men receiving continuous long-term [testosterone therapy], the investigators concluded.

References

1. Saad F, Haider A, Haider KS, Doros G, Traish A. Long-term testosterone therapy improves erectile function and reduces mortality in men with hypogonadism and type 2 diabetes updated results from a registry study. Paper presented at 2021 Sexual Medicine Society of North America Fall Scientific Meeting; October 21-24, 2021; Scottsdale, Arizona. Abstract 001

2. Hackett G, Cole N, Mulay A, Strange RC, Ramachandran S. Long-term testosterone therapy in type 2 diabetes is associated with reduced mortality without improvement in conventional cardiovascular risk factors. BJU Int. 2019;123(3):519-529. doi:10.1111/bju.14536

Continued here:
Long-term testosterone improves erectile function, reduces mortality in men with hypogonadism and diabetes - Urology Times

JATENZO (testosterone undecanoate) is the first and only FDA-approved oral softgel for testosterone replacement therapy (TRT) in adult males who have deficient testosterone due to certain medical conditions

Upon issuance, Clarus plans to list these patents in FDAs Orange Book, which would bring the total number of Orange Book-listed patents covering JATENZO (testosterone undecanoate) to seven

NORTHBROOK, Ill., Oct. 26, 2021 (GLOBE NEWSWIRE) -- Clarus Therapeutics Holdings, Inc. (Clarus) (Nasdaq:CRXT), a pharmaceutical company dedicated to providing solutions to unmet medical needs by advancing androgen and metabolic therapies for men and women, today announcedthat it has received two notices of allowance from the United States Patent and Trademark Office (USPTO) for claims that cover its oral testosterone replacement product, JATENZO (testosterone undecanoate).

Patent application No. 16/656,157 entitled Oral Testosterone Ester Formulations and Methods of Treating Testosterone Deficiency Comprising Same and patent application No. 15/814,162 entitled Pharmaceutical Delivery Systems for Hydrophobic Drugs and Compositions Comprising Same both cover Clarus approved product JATENZO (testosterone undecanoate). The U.S. patents scheduled to issue from these applications will expire in 2030 and 2026, respectively.

These recent patent allowances by the USPTO are another important milestone in protecting the commercial potential of JATENZO and the life cycle management programs we have under development for this lead asset, said Dr. Robert Dudley, Founder, President and Chief Executive Officer of Clarus. Once issued, these two new patents will be listed in FDAs Orange Book and will bring the total number of patents that protect JATENZO to seven. These new patents will further strengthen the broad and robust intellectual property portfolio for JATENZO.

About Male Hypogonadism Male hypogonadism is a condition that results when the testes do not produce enough testosterone. Symptoms associated with male hypogonadism can include depression, decreased sex drive, decreased muscle mass, and decreased bone density, among others. An estimated 20 million men in the U.S. have hypogonadism, with approximately 6 million patients diagnosed. Treatments for male hypogonadism may include testosterone replacement therapy (TRT).

About Clarus Therapeutics Holdings, Inc.Clarus Therapeutics Holdings, Inc. is a pharmaceutical company with expertise in developing androgen and metabolic therapies for men and women including potential therapies for orphan indications. Clarus Therapeutics first commercial product is JATENZO. For more information, visit http://www.clarustherapeutics.comand http://www.jatenzo.com. Follow us on Twitter (@Clarus_Thera) and LinkedIn (Clarus Therapeutics).

Clarus Forward-Looking StatementsCertain statements in this press release constitute forward-looking statements for purposes of the federal securities laws. The words anticipate, believe, contemplate, continue, could, estimate, expect, intends, may, might, plan, possible, potential, predict, project, should, will, would and similar expressions may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. Clarus forward-looking statements in this press release include, but are not limited to, statements regarding the issuance of these patents, listing in the FDAs Orange Book and the effect of these patents on the JATENZO patent portfolio. These forward-looking statements are based on current expectations and beliefs concerning future developments and their potential effects. There can be no assurance that future developments affecting us will be those that Clarus has anticipated. These forward-looking statements involve a number of risks, uncertainties (some of which are beyond Clarus control) or other assumptions that may cause actual results or performance to be materially different from those expressed or implied by these forward-looking statements. These risks and uncertainties include, but are not limited to, the risks associated with pharmaceutical development, risks associated with Clarus financial position, and those factors described under the heading Risk Factors in the prospectus filed with the Securities and Exchange Commission (the SEC) under Rule 424(b)(3) on October7, 2021, and those that are included in any of Clarus future filings with the SEC. Should one or more of these risks or uncertainties materialize, or should any of Clarus assumptions prove incorrect, actual results may vary in material respects from those projected in these forward-looking statements. Some of these risks and uncertainties may in the future be amplified by the COVID-19 pandemic and there may be additional risks that Clarus considers immaterial, or which are unknown. It is not possible to predict or identify all such risks. Clarus forward-looking statements only speak as of the date they are made, and Clarus does not undertake any obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable securities laws.

Clarus Investor Relations Contact:Kara Stancellkstancell@clarustherapeutics.com(847) 562-4300 x 206

About JATENZO

IndicationJATENZO (testosterone undecanoate) capsules, CIII, is an androgen indicated for testosterone replacement therapy in adult males for conditions associated with a deficiency or absence of endogenous testosterone:

Limitation of useSafety and efficacy of JATENZO in males less than 18 years old have not been established.

IMPORTANT SAFETY INFORMATION

WARNING: INCREASES IN BLOOD PRESSURE

CONTRAINDICATIONSJATENZO is contraindicated in men with breast cancer or known or suspected prostate cancer. JATENZO is contraindicated in women who are pregnant as testosterone may cause fetal harm.

WARNINGS AND PRECAUTIONS

ADVERSE EVENTSThe most common adverse events of JATENZO (incidence 2%) are headache (5%), increased hematocrit (5%), hypertension (4%), decreased HDL (3%), and nausea (2%).

These are not all of the risks associated with JATENZO. For more information, click here for full Prescribing Information, including BOXED WARNING on increases in blood pressure. You can also obtain information regarding JATENZO at http://www.jatenzo.com.

2021 Clarus Therapeutics, Inc. All rights reserved.

Link:
Clarus Therapeutics Announces Two Notices of Allowance for - GlobeNewswire

Spains former king Juan Carlos was allegedly injected with female hormones by Spanish secret service to control his rampant sex drive, an ex-police chief has sensationally claimed.

Jose Manuel Villarejo, an ex-police commissioner currently on trial over blackmail allegations, told a parliamentary hearing on Wednesday that Spains National Intelligence Centre (CNI) had to administer the 83-year-old exiled monarch female hormones and testosterone inhibitors to lower his libido.

Giving reasons for the extreme action, Villarejo said Carlos sex drive was considered as a problem for the state because he was such an ardently passionate person, Spanish media reported.

During the hearing, the former police chief said he had been tasked to recover medical reports relating to scans that Juan Carlos had while he was undergoing treatment for a benign tumour.

Also read |Spain's former king Juan Carlos flees the country

He said, There were traces not of bromide (a sedative) but of testosterone inhibitors.

The revelations come after a Spanish author and military historian Amadeo Martinez Ingles wrote a book entitled Juan Carlos: The King Of 5,000 Lovers, detailing evidence of his sexual history and describing the king as a "rampant sex addict".

It has been speculated that the former king has had intimate relations with over 5,000 women, including Danish-German philanthropist Corinna Larsen, Spanish singer Sara Montiel, Belgian governess Liliane Sartiau and Italian princess Maria Gabriela de Saboya, besides his wife, Queen Sofia.

Also read |Spain's former king Juan Carlos has been in UAE since August 3

Villarejos trial opened this month, in which he is accused of having covertly recorded conversations with the elite for the purposes of blackmailing or ruining their reputation on behalf of other powerful clients.

He denied having any involvement in the effort to bring Juan Carlos notorious sex drive under control and said he found out about it from Corinna Larsen, a former lover of the ex-monarch now living in London.

The former king reigned from 1975 to 2014, but abdicated his throne for of his son. He fled Spain for Abu Dhabi, United Arab Emirates, last year amid a multi-million dollar corruption scandal.

(With inputs from agencies)

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Spains former king Juan Carlos injected with female hormones to control his sex drive: Ex-cop - WION

Testosterone Injectable Market study by Future Market Insights provides details about the market dynamics affecting the market, Covid-19 Impact, Market scope, Market segmentation and overlays shadow upon the leading market players highlighting the favorable competitive landscape and trends prevailing over the years.

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This Report encloses comprehensive analysis on the market and are assessed through volume and value data validated on three approaches including top companies revenues. It concludes with precise and authentic market estimations considering all the parameters and market dynamics. Every crucial and decisive detail for the development and restriction of the market is mentioned in fine points with solutions and suggestions that may affect the market in near future. Segmentation of the market are studied specifically to give profound knowledge for supplementary market investments.

The report Testosterone Injectable Market gives varied description about the segmentation of the market on the basis of segmented Dosage, Route of Administration and Application, and leads with a descriptive structure of the trends and restrictions of the various segments and sub segments. It also provides the market size and estimates a forecast from the year 2018 to 2028 with respect to major regions, namely; North America, Europe, Asia-Pacific (APAC), Middle East and Africa (MEA) and South & Central America. The report also provides exhaustive PEST analysis for all five regions after evaluating political, economic, social and technological factors effecting the Testosterone Injectable Market.

The report facilitates in determining and interpreting the key market players, portfolios with necessary information such as company profiles, components and services offered, financial information of past few years, key developments in past few years, that helps in constructing strategies to gain competitive advantage in the long run. The report also analyzes factors affecting Testosterone Injectable Market from both demand and supply side and further evaluates market dynamics effecting the market during the forecast period i.e., drivers, restraints, opportunities, and future trend.

Leading Testosterone Injectable Market Players:

Key Elements that the report acknowledges:

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Excerpt from:
Testosterone Injectable Market Trend 2021, Growth, Leading Companies with Impact of Covid-19, Business Scenario, Emerging Dynamics, Industry Share and...

Scientists are learning more and more about human biological variation, including of sex characteristics. But images of the human body in anatomy remain mostly muscular, white, and male with limited diversity, including of sex.

Intersex people represent just under 2% of the population a comparable percentage to people born with red hair. Yet anatomy textbooks used in Australian medical schools almost completely stick to the male-female sex binary. In our earlier research we found intersex was included in only five of 6,004 images across 17 texts. This marginalises intersex people, who have been persistently discriminated against within the health-care system.

The intersex community is the often forgotten I in LGBTQI+. Intersex Human Rights Australia highlights the need for increased visibility and to prevent unnecessary surgeries. Now there are fresh calls for health and medical students to learn about sex characteristics as a continuum rather than as male or female.

Read more: Marriage equality was momentous, but there is still much to do to progress LGBTI+ rights in Australia

Sex development in utero is complex, involving at least 70 different genes.

Our sex is defined by our genes (Y or X chromosome), gonads (ovaries or testes), reproductive tract, and external genitalia.

Whether a foetus develops female, intersex or male characteristics is determined by four key elements. These are the Y chromosome and its sex-determining gene (SRY gene), and two hormones (anti-Mullerian hormone and testosterone).

A foetus with all four elements will develop male sex characteristics.

At 67 weeks gestation, the SRY gene on the Y chromosome signals the gonads to develop into testes. About 23 weeks later, secretion of two hormones by the testes directs further sex development. Anti-Mullerian hormone stops female sex characteristic development. Testosterone stimulates development of the male reproductive tract and external genitalia.

When all four elements are absent, female sex characteristics develop.

Without a Y chromosome and its SRY gene, the gonads develop into ovaries. Without anti-Mullerian hormone or testosterone production, the female reproductive tract and external genitalia develop.

The presence of some but not all of these elements results in the development of intersex characteristics.

Intersex can include both or a combination of male and female sex characteristics, depending on variations in chromosomes, genes or hormones. This represents the continuum of the sex spectrum between the male and female binaries.

Known variations in the Y and X chromosomes include XY (genetic male), XXY (Klinefelter syndrome), X (Turner syndrome), XX (genetic female). Variations in the gonads include the presence of both ovaries and testes, or only partial development of either. Other intersex variations include a combination of male and female genitalia, and external genitalia that differs in sex to the genetic sex.

Intersex traits are not always visible at birth. Individuals may not realise they are intersex until puberty, or only if they undergo assessment for infertility or genetic testing.

There is a tragic history of irreversible surgical interventions in intersex infants and children. This was often without their consent, or with parents coerced to consent.

These surgeries have been to normalise external genitalia to a male or female binary. The impact of these procedures may violate human rights. They can be devastating for intersex peoples lifelong physical and mental well-being.

The UN Office of the High Commissioner for Human Rights description of intersex is having sex characteristics that do not fit typical binary notions of male or female bodies. But even this pathologises intersex by indicating that intersex people do not fit.

Normalisation of sex variation and increased visual representation of intersex in anatomy is necessary to reduce stigma.

The minimal visual representation of intersex people in anatomy textbooks can affect students attitudes towards this. We have previously found viewing gender-biased images of anatomy is associated with higher implicit gender bias. Todays students are our next generation of doctors and health-care workers.

Read more: What are gender pronouns and why is it important to use the right ones?

Teaching sex characteristics based on a male-female binary is inaccurate and outdated. Weve also shown it negatively influences the healthcare of intersex individuals.

Both the University of Wollongong and the University of New South Wales are developing inclusive anatomy curricula within their medicine and health degrees. Harvard Medical School and University of British Columbia are also developing online, accessible resources to promote inclusive anatomical representation in medical education.

Inclusive teaching and knowledge of sex variation can be transformative beyond anatomy.

Teaching sex characteristics as a continuum will increase the visibility and understanding of intersex. Removing the stigma associated with sex (and other) variations in anatomy, and medical and health education is essential for optimal health, well-being, belonging and connection for everyone.

Read more from the original source:
Anatomy texts should show sex as a spectrum to include intersex people - The Conversation AU

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