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Newswise A new research study published in JMIR Diabetes evaluated the real-world effectiveness of the Fitterfly Diabetes CGM digital therapeutic program for the management of glycemic control and weight in people with type 2 diabetes mellitus. The study led by Shilpa Joshi, Arbinder Singal, and colleagues found significant improvements in both blood glucose levels and weight management in participants enrolled in the 90-day program.

The Fitterfly Diabetes CGM program, delivered through the Fitterfly mobile app coupled with continuous glucose monitoring (CGM) technology, provides users with tailored recommendations on nutrition based on personalized glycemic response data, exercise, and behavior modifications to help manage type 2 diabetes. The program is designed to provide individuals with the tools they need to manage their condition effectively and make long-term lifestyle changes that would support their overall health.

This study analyzed de-identified data of 109 participants with type 2 diabetes. The program was delivered in 3 phases. First, the participants CGM readings were observed for 1 week; next, they received diet- and exercise-based interventions via Fitterfly app and coaches (nutritionists, psychologists, and physiotherapists); and finally, the researchers tracked whether the participants were able to sustain these newly introduced lifestyle modifications over the next 3 months.

The researchers found that, at the end of the 90-day program, about 85% of all participants observed an average reduction of 1.2% in hemoglobin A1c (HbA1c) levels, an important indicator of glycemic control. The reduction was even higher, at about 2.6%, for those participants who started the program with an HbA1c level greater than 9%. The study participants also lost an average of 2.05 kg body weight, and their BMI reduced by 0.74 kg/m2.

Dr Arbinder Singal, CEO and cofounder of Fitterfly, said, Type 2 diabetes is a huge health care concern in India. With the use of newer tools such as digital therapeutics now getting adopted by people and enterprise partners, and getting prescribed by physicians, we are bridging the gap for behavior change. The study affirms our belief that digital therapeutic programs can provide clinically validated outcomes and help the population at scale.

The program's easy-to-use app interface and personalized approach make it a promising option for individuals looking to improve their health and manage diabetes effectively. Interestingly, the study also found that participants who engaged more with the app throughout the programs duration had better clinical outcomes, especially with regard to weight reduction. Thus, Fitterflys CGM program could be a valuable tool for health care professionals in managing type 2 diabetes and supporting weight loss goals.

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About Fitterfly

Fitterfly is a healthtech start-up working in the area of metabolic health offering outcome-focused digital therapeutic programs for conditions like diabetes, obesity, and heart disease. Founded in 2016 by Dr Arbinder Singal and Shailesh Gupta, Fitterfly has over 300 employees and has headquarters in Mumbai, India. The Fitterfly management team comprises senior doctors, nutritionists, fitness experts, psychologists, management experts, and technologists working together with the sole aim of preventing, reversing, and managing metabolic health conditions such as prediabetes, diabetes, obesity, hypertension, and heart disease, thereby increasing quality of life and health for people.

Fitterfly has presented and published more than 50+ abstracts and papers on outcomes and impact of technology in disease management. Apart from path-breaking research, Fitterfly has won several coveted awards in the start-up and health care arena, such as Economic Times Healthtech Start-up of the Year 2022, Zee News Healthtech Start-up of the Year 2022, Global Digital Health Award 2022, RSSDI Award for Innovation in Diabetes 2021, Medix Healthtech Challenge 2021, and Healthtech Start-up of the Year 2021 by Entrepreneur.

More information about Fitterfly is available at http://www.fitterfly.com or connect with us via Twitter, Linkedin, Youtube, Facebook, and Instagram.

About JMIR Publications

JMIR Publications is a leading, born-digital, open access publisher of 30+ academic journals and other innovative scientific communication products that focus on the intersection of health, and technology. Its flagship journal, the Journal of Medical Internet Research, is the leading digital health journal globally in content breadth and visibility, and is the largest journal in the medical informatics field.

To learn more about JMIR Publications, please visit jmirpublications.com or connect with us via Twitter, LinkedIn, YouTube, Facebook, and Instagram.

Head office: 130 Queens Quay East, Unit 1100, Toronto, ON, M5A 0P6 Canada

Media contact: [emailprotected]

The content of this communication is licensed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, published by JMIR Publications, is properly cited.

Please cite the original article as:

Joshi S, Verma R, Lathia T, Selvan C, Tanna S, Saraf A, Tiwaskar M, Modi A, Kalra S, K V, Chitale M, Malde F, Abdul Khader M, Singal AKFitterfly Diabetes CGM Digital Therapeutics Program for Glycemic Control and Weight Management in People With Type 2 Diabetes Mellitus: Real-world Effectiveness EvaluationJMIR Diabetes 2023;8:e43292doi: 10.2196/43292

PMID: 37133922

Excerpt from:
New study finds that Fitterfly Diabetes Digital Therapeutics Program Improves Blood Sugar Levels and Promotes Weight Loss in Patients With Type 2...

In the quest for weight loss and improved nutrition, meal replacement shakes have gained popularity as a convenient and effective option. These shakes offer a quick and easy way to consume essential nutrients while managing calorie intake.

In this article, we will explore the benefits and different variations of meal replacement shakes, including those designed specifically for weight loss, as well as meal replacement drinks and smoothies.

When it comes to shedding excess pounds, meal replacement shakes can be a valuable tool. These shakes are typically low in calories while providing a balanced mix of macronutrients, including proteins, carbohydrates, and fats.

By substituting one or two meals with a shake, individuals can reduce their overall calorie intake, leading to weight loss over time.

Meal replacement shakes for weight loss often include added ingredients that promote satiety and control hunger. Fiber and protein are commonly incorporated into these shakes to help keep you feeling full and satisfied throughout the day. Moreover, they are often fortified with essential vitamins and minerals to ensure that you still receive adequate nutrition despite consuming fewer calories.

In addition to shakes, meal replacement drinks offer another convenient option for individuals seeking a quick and nutritious meal on the go. These drinks are typically pre-packaged and ready to consume, making them ideal for busy individuals or those lacking time for meal preparation.

Meal replacement drinks come in a variety of flavors and formulations, catering to different dietary preferences and requirements. Some are dairy-based, while others are plant-based, providing options for individuals with lactose intolerance or those following a vegan lifestyle. These drinks offer a balanced combination of proteins, carbohydrates, and fats, providing a satisfying meal replacement option in liquid form.

For those who prefer a refreshing and fruity option, meal replacement smoothies are an excellent choice. These blends combine fruits, vegetables, proteins, and healthy fats to create a nutritionally dense meal replacement option.

By incorporating ingredients such as spinach, berries, almond milk, and protein powder, or even coffee for a quick energy boost, individuals can enjoy a delicious smoothie after a workout while benefiting from its nutritional value.

Meal replacement smoothies offer versatility, allowing individuals to customize their blends based on personal preferences and dietary needs. They can be an excellent choice for individuals looking to increase their intake of fruits and vegetables while still enjoying a convenient and satisfying meal.

Meal replacement shakes, drinks, and smoothies provide individuals with a convenient and effective way to manage their calorie intake, promote weight loss, and improve overall nutrition.

Whether you opt for a shake, drink, or smoothie, these meal replacements offer a balanced mix of macronutrients and essential vitamins and minerals. They can be particularly beneficial for those with busy lifestyles or individuals seeking an alternative to traditional meals.

As with any dietary change, it is important to consult with a healthcare professional or registered dietitian before incorporating meal replacement shakes into your routine, especially if you have any underlying health conditions or specific dietary needs.

Remember, meal replacement shakes should not be considered as a long-term solution. They are best used as a temporary aid in achieving weight loss goals or as a convenient option during busy periods. Combined with a balanced diet and regular exercise, meal replacement drinks can play a valuable role in achieving and maintaining a healthy weight and lifestyle.

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The Power of Meal Replacement Shakes: A Path to Weight Loss Success - Sportskeeda

Bowel cancer also known as colorectal cancer affects large bowel which is made up of colon and rectum. Lifestyle factors can play a big role in development of bowel cancer. Obese or overweight people or those who indulge in unhealthy lifestyle habits like consuming alcohol, smoking tobacco, and eating high-calorie food are at an increased risk of this cancer. Studies suggest that one can cut risk of bowel cancer by keeping a healthy weight, doing exercise, eating healthy and avoiding alcohol and tobacco. Recognising early signs of bowel cancer can help improve survival rate. (Also read: Obesity increases the risk of colorectal cancer: Study)

Bowel cancer is a type of cancer that occurs owing to the abnormal growth of cells in the lining of the large bowel (colon) and rectum. It is also termed colorectal cancer.

"It strikes the large bowel which is made up of colon and rectum. This cancer may affect people at any age. Early detection is the key to the prevention and effective treatment. Therefore, bowel cancer screenings are advised by early 40s for every individual," Dr Balkishan Gupta, Director, Minimal Invasive GI and Colorectal Surgeon, Marengo Asia Hospitals Faridabad told HT Digital.

Dr Gupta says one needs to pay attention to changes in bowel habits or abdominal cramping, unexplained weight loss and fatigue as all these symptoms can indicate trouble.

"If you experience symptoms like blood in your poo, changes in bowel habit (diarrhoea, constipation or the feeling of incomplete emptying), changes in your bowel movement (like thin bowel stools), bloating, abdominal pain or cramping, anal or rectal pain, unexplained weight loss, extreme fatigue for no reason, a lump in the anus or rectum, blood in the urine or passing urine frequently or during the night, change in urine colour (dark, rusty or brown), you should seek medical advice immediately. If these symptoms are left unnoticed, they may get worse," says Dr Gupta.

Dr Gupta says the following people are more at risk of colorectal cancer than others:

- People with a family history of bowel cancer, an inherited bowel condition like familial adenomatous polyposis, or hereditary non-polyposis colorectal cancer, also called Lynch syndrome are more susceptible to develop bowel cancer.

- People with long-term inflammatory bowel diseases like Crohns or ulcerative colitis or who have a history of non-cancerous growths (polyps or adenomas) are more likely to get affected by this life-threatening condition.

- Factors such as obesity, smoking, a low fibre diet and/or high in processed and red meats and heavy alcohol use may raise the risk of higher rates of bowel cancer.

"To diagnose this disease, the patients may be advised to undergo physical examination, blood tests, Immunochemical faecal occult blood test (iFOBT), Colonoscopy, Flexible sigmoidoscopy, MRI, ST Scan and PET Scan," says Dr Gupta.

To minimize the risk of bowel cancer, it is advisable to have a balanced diet with plenty of fresh fruit and vegetables. Avoid or limit intake of red meat, refrain from eating processed meats, say no to smoking or excess alcohol consumption, do regular exercise and maintain a healthy body weight.

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Early bowel cancer signs and symptoms that should not be ignored - Hindustan Times

The future of Google Search is AI. But not in the way you think. The company synonymous with web search isnt all in on chatbots (even though its building one, called Bard), and its not redesigning its homepage to look more like a ChatGPT-style messaging system. Instead, Google is putting AI front and center in the most valuable real estate on the internet: its existing search results.

To demonstrate, Liz Reid, Googles VP of Search, flips open her laptop and starts typing into the Google search box. Why is sourdough bread still so popular? she writes and hits enter. Googles normal search results load almost immediately. Above them, a rectangular orange section pulses and glows and shows the phrase Generative AI is experimental. A few seconds later, the glowing is replaced by an AI-generated summary: a few paragraphs detailing how good sourdough tastes, the upsides of its prebiotic abilities, and more. To the right, there are three links to sites with information that Reid says corroborates whats in the summary.

Google calls this the AI snapshot. All of it is by Googles large language models, all of it sourced from the open web. Reid then mouses up to the top right of the box and clicks an icon Googles designers call the bear claw, which looks like a hamburger menu with a vertical line to the left. The bear claw opens a new view: the AI snapshot is now split sentence by sentence, with links underneath to the sources of the information for that specific sentence. This, Reid points out again, is corroboration. And she says its key to the way Googles AI implementation is different. We want [the LLM], when it says something, to tell us as part of its goal: what are some sources to read more about that?

A few seconds later, Reid clicks back and starts another search. This time, she searches for the best Bluetooth speakers for the beach. Again, standard search results appear almost immediately, and again, AI results are generated a few seconds later. This time, theres a short summary at the top detailing what you should care about in such a speaker: battery life, water resistance, sound quality. Links to three buying guides sit off to the right, and below are shopping links for a half-dozen good options, each with an AI-generated summary next to it. I ask Reid to follow up with the phrase under $100, and she does so. The snapshot regenerates with new summaries and new picks.

These AI snapshots will appear at the top of Search and pull information from all over the web. Image: Google

This is the new look of Googles search results page. Its AI-first, its colorful, and its nothing like youre used to. Its powered by some of Googles most advanced LLM work to date, including a new general-purpose model called PaLM 2 and the Multitask Unified Model (MUM) that Google uses to understand multiple types of media. In the demos I saw, its often extremely impressive. And it changes the way youll experience search, especially on mobile, where that AI snapshot often eats up the entire first page of your results.

There are some caveats: to get access to these AI snapshots, youll have to opt in to a new feature called Search Generative Experience (SGE for short), part of an also-new feature called Search Labs. Not all searches will spark an AI answer the AI only appears when Googles algorithms think its more useful than standard results, and sensitive subjects like health and finances are currently set to avoid AI interference altogether. But in my brief demos and testing, it showed up whether I searched for chocolate chip cookies, Adele, nearby coffee shops, or the best movies of 2022. AI may not be killing the 10 blue links, but its definitely pushing them down the page.

SGE, Google executives tell me over and over, is an experiment. But theyre also clear that they see it as a foundational long-term change to the way people search. AI adds another layer of input, helping you ask better and richer questions. And it adds another layer of output, designed to both answer your questions and guide you to new ones.

An opt-in box at the top of search results might sound like a small move from Google compared to Microsofts AI-first Bing redesign or the total newness of ChatGPT. But SGE amounts to the first step in a complete rethinking of how billions of people find information online and how Google makes money. As pixels on the internet go, these are as consequential as it gets.

The AI snapshots borrow colors from the content they discover and change depending on what you search. Image: Google

Asked and answered

Google feels pretty good about the state of its search results. Were long past the 10 blue links era of 25 years ago when you Googled by typing in a box and getting links in return. Now, you can search by asking questions aloud or snapping a picture of the world, and you might get back everything from images and podcasts to TikToks.

Many searches are already well served by these results. If youre going to Google and searching Facebook to land on facebook.com or youre looking for the height of the Empire State Building, youre already good to go.

But theres a set of queries for which Google has never quite worked, which is where the company is hoping AI can come in. Queries like Where should I go in Paris next week? or Whats the best restaurant in Tokyo? These are hard questions to answer because theyre not actually one question. Whats your budget? What days are all the museums open in Paris? How long are you willing to wait? Do you have kids with you? On and on and on.

Theres a set of queries for which Google has never quite worked, which is where the company is hoping AI can come in

The bottleneck turns out to be what I call the orchestration of structure, says Prabhakar Raghavan, the SVP at Google who oversees Search. Much of that data exists somewhere on the internet or even within Google museums post hours on Google Maps, people leave reviews about wait times at restaurants but putting it all together into something like a coherent answer is really hard. People want to say, plan me a seven-day vacation, Raghavan says, and they believe if the language model outputs, it should be right.

One way to think about these is simply as questions with no right answer. A huge percentage of people who come to Google arent looking for a piece of information that exists somewhere. Theyre looking for ideas, looking to explore. And since theres also likely no page on the internet titled Best vacation in Paris for a family with two kids, one of whom has peanut allergies and the other of whom loves soccer, and you definitely want to go to the Louvre on the quietest possible day of the week, the links and podcasts and TikToks wont be much help.

Because theyre trained on a huge corpus of data from all over the internet, large language models can help answer those questions by essentially running lots of disparate searches at once and then combining that information into a few sentences and a few links. Lots of times you have to take a single question and break it into 15 questions to get useful information from search, Reid says. Can you just ask one? How do we change how the information is organized?

Thats the idea, but Raghavan and Reid are both quick to point out that SGE still cant do these completely creative acts very well. Right now, its going to be much more handy for synthesizing all the search data behind questions like what speaker should I buy to take into the pool. Itll do well with what were the best movies of 2022, too, because it has some objective Rotten Tomatoes-style data to pull from along with the internets many rankings and blog posts on the subject. AI appears to make Google a better information-retrieval machine, even if its not quite ready to be your travel agent.

One thing that didnt show up in most SGE demos? Ads. Google is still experimenting with how to put ads into the AI snapshots, though rest assured, theyre coming.Googles going to need to monetize the heck out of AI for any of this to stick.

Right now, AI hasnt really changed how Google ads work. But it will. Image: Google

The Google Bot

At one point in our demo, I asked Reid to search only the word Adele. The AI snapshot contained more or less what youd expect some information about her past, her accolades as a singer, a note about her recent weight loss and then threw in that her live performances are even better than her recorded albums. Googles AI has opinions! Reid quickly clicked the bear claw and sourced that sentence to a music blog but also acknowledged that this was something of a system failure.

Googles search AI is not supposed to have opinions. Its not supposed to use the word I when it answers questions. Unlike Bings multiple-personality chaos or ChatGPTs chipper helper or even Bards whole droll middle school teacher vibe, Googles search AI is not trying to seem human or affable. Its actually trying very hard to not be those things. You want the librarian to really understand you, Reid says. But most of the time, when you go to the library, your goal is for them to help you with something, not to be your friend. Thats the vibe Google is going for.

The reason for this goes beyond just that strange itchy feeling you get talking to a chatbot for too long. And it doesnt seem like Google is just trying to avoid super horny AI responses, either. Its more a recognition of the moment were in: large language models are suddenly everywhere, theyre far more useful than most people would have guessed, and yet they have a worrying tendency to be confidently wrong about just about everything. When that confidence comes in perfectly formed paragraphs that sound good and make sense, people are going to believe the wrong stuff.

A few executives I spoke to mentioned a tension in AI between factual and fluid. You can build a system that is factual, which is to say it offers you lots of good and grounded information. Or you can build a system that is fluid, feeling totally seamless and human. Maybe someday youll be able to have both. But right now, the two are at odds, and Google is trying hard to lean in the direction of factual. The way the company sees it, its better to be right than interesting.

Google projects a lot of confidence in its ability to be factually strong, but recent history seems to suggest otherwise

Google projects a lot of confidence in its ability to be factually strong, but recent history seems to suggest otherwise. Not only is Bard less wacky and fun than ChatGPT or Bing, but its also often less correct it makes basic mistakes in math, information retrieval, and more. The PaLM 2 model should improve some of that, but Google certainly hasnt solved the AI lies problem by a long shot.

Theres also the question of when AI should appear at all. Sometimes its obvious: the snapshots shouldnt appear if you ask sensitive medical questions, Reid says, or if youre looking to do something illegal or harmful. But theres a wide swath of searches where AI may or may not be useful. If I search Adele, some basic summary information at the top helps; if I search Adele music videos, Im much more likely to just want the YouTube videos in the results.

Google can afford to be cautious here, Reid says, because the fail state is just Google search. So whenever the snapshot shouldnt appear, or whenever the models confidence score is low enough that it might not be more useful than the top few results, its easy to just not do anything.

Bold and responsible

Compared to the splashy launch of the new Bing or the breakneck developmental pace of ChatGPT, SGE feels awfully conservative. Its an opt-in, personality-free tool that collates and summarizes your search results. For Google, suddenly in an existential crisis over the fact that AI is changing the way people interact with technology, is that enough?

A couple of executives used the same phrase to describe the companys approach: bold and responsible. Google knows it has to move fast not only are chatbots booming in popularity, but TikTok and other platforms are stealing some of the more exploratory search out from under Google. But it also has to avoid making mistakes, giving people bad information, or creating new problems for users. To do that would be a PR disaster for Google, it would be yet more reason for people to try new products, and it would potentially destroy the business that made Google a trillion-dollar company.

So, for now, SGE remains opt-in and personality-free. Raghavan says hes comfortable playing a longer game: knee-jerk reacting to some trend is not necessarily going to be the way to go. Hes also convinced that AI is not some panacea that changes everything that 10 years from now, well all do everything through chatbots and LLMs. I think its going to be one more step, he says. Its not like, Okay, the old world went away. And were in a whole new world.

In other words, Google Bard is not the future of Google Search. But AI is. Over time, SGE will start to come out of the labs and into search results for billions of users, mingling generated information with links out to the web. It will change Googles business and probably upend parts of how the web works. If Google gets it right, it will trade 10 blue links for all the knowledge on the internet, all in one place. And hopefully telling the truth.

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AI is coming to Google search through Search Generative Experience - The Verge

People may find it difficult to lose excess weight for many reasons, including lifestyle and mental factors. Other reasons may be hormonal factors such as menopause or changes in body composition as a person ages.

There is no one size fits all solution for weight loss. Regular physical activity and following a healthy, balanced diet almost always play a role. However, managing medical and mental health conditions can also affect a persons weight.

This article examines the reasons it may be difficult for someone to lose weight. It also discusses the research on managing weight at different ages and possible barriers to weight loss. Finally, it provides weight-loss tips and answers some frequently asked questions.

Research from 2018 shows that throughout adulthood, there is a natural increase in body fat up to the eighth decade of life, after which it decreases. The body typically redistributes fat to the middle area, increasing waist size. There is also generally a gradual loss of muscle mass.

It is important to manage these natural changes, as older adults with obesity are at a higher risk of conditions such as heart disease and diabetes and experiencing falls and reduced quality of life. Research from 2017 indicates that weight loss and improved fitness in older adults can improve overall function and health.

A 2019 review of older adults experiences of weight management found that the following barriers to losing weight were apparent:

However, the researchers note that due to the study population, the findings do not reflect the views of nonwhite ethnic groups in which attitudes toward weight and aging may differ.

Body composition changes as we age, and our weight gradually increases from a young age to about 75 years old. There is an increase in overall adiposity and fat, as well as a decrease in lean muscle mass.

After age 30, people may have more responsibilities and work commitments that can prevent them from being physically active. They may also rely more on processed foods if they are busy or stressed. These factors can make it more challenging to maintain a moderate weight.

While aging comes with increased body fat and sometimes weight, there are additional reasons that people who were assigned female at birth may find it difficult to lose weight after the age of 40.

One reason is that the menopausal transition most often begins between the ages of 4555.

A 2021 review notes that over 43% of menopausal women have obesity, and the reasons are multifactorial. It explains that during menopause, there is an increase in fat mass and a decrease in lean muscle mass. Additionally, medications doctors prescribe to manage the hormonal and physical changes of menopause, such as hormone replacement and antidepressants, have been shown to promote weight gain.

According to the review, 20% of females gain at least 10 pounds during menopause. This may be due to hormonal changes but appears to be also related to increasing age and decreasing energy expenditure.

Learn more about menopause.

Losing weight after age 60 may be more challenging if someone is less physically active. For example, a person may have retired from work or have health conditions that limit their activity or ability to exercise.

In addition, older adults generally have lower calorie needs but similar or even increased nutrient needs compared to younger adults. Therefore, they may need to adjust their eating habits to manage their weight as they age.

Energy deficit is the key component for weight loss. An energy deficit is when someone burns more calories than they are consuming.

A 2021 review explains that the calories-in, calories-out model for weight loss has focused on eating less and moving more. However, the review advises that energy intake and expenditure are dynamic metabolic processes, and the body may make adaptations that resist weight loss.

Additionally, a review from 2018 notes that conventional low calorie diets recommend a calorie deficit of 500750 calories a day by limiting calories to 1,2001,500 daily for females and 1,5001,800 for people assigned male at birth.

Various weight-loss diets may limit fats or carbohydrates or use meal replacements. However, while some sources say that the macronutrient content of a diet is important, the review states that longer-term studies have yet to verify this.

The review concludes that while there is no single strategy for weight loss, the most effective eating plan is one that someone can maintain in the long term to avoid regaining the weight they may lose. It is also important that an eating plan is nutritionally adequate, safe, and affordable.

An individual can speak with a healthcare professional or dietitian for more information on healthy and balanced eating plans.

Read about weight loss meal plans.

Experts advise that people may initially lose more weight when they start a weight loss plan, but as their body adjusts, people frequently experience a weight loss plateau. This is a time when a persons weight loss may seem to become stagnant.

This may be due to the body having a set point that it levels out to and metabolic reactions that lead to decreased energy expenditure and increased hunger. A weight loss plateau can also be an important recovery period for a persons body.

It can be a time when the body is readjusting hormone levels or its metabolic rate. It can also mean the body needs time to increase or regain any lost lean muscle mass.

An individual can work with a healthcare professional to find the most effective way of overcoming a weight loss plateau.

Read more about weight loss plateaus.

Daniel Bubnis, MS, NASM-CPT, NASE Level II-CSS, reviewed the following common questions about weight loss:

There are many reasons why weight loss can affect a person mentally. One reason is that they may be expecting too much too quickly. When those results do not happen, it makes them feel discouraged. Symptoms such as fatigue or sleeplessness can also make weight loss more difficult. In addition, high stress levels can influence a persons mental and physical health and affect weight loss.

Everyone is different. For some people, weight loss may take longer due to medical conditions, overall health, and mental health. If an individual has concerns about their weight loss, they can speak with a healthcare professional for guidance.

Weight loss may become more difficult as someone ages or during menopause. Many factors influence weight loss, including sleep, stress, and physical or mental health.

The most effective eating plan is one that someone can maintain and is nutritionally adequate. Eating a diet rich in vegetables and lean protein and avoiding late-night eating are strategies a person can try.

It is important for people to combine a healthy eating plan and regular physical activity for weight loss. An individual can seek support from a healthcare professional if they find it difficult to lose weight.

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Weight loss: Barriers, aging, and how it works - Medical News Today

Managing weight can be challenging for individuals with diabetes, but its a critical aspect of maintaining overall health and blood sugar control. This article will provide helpful tips for losing weight if you have diabetes, emphasizing a balanced and sustainable approach.

Consult a Healthcare Professional:Before starting any weight loss journey, consult your healthcare professional or a registered dietitian. They can help you develop a personalized meal plan and set realistic weight loss goals that align with your unique needs and circumstances.

Focus on Balanced Nutrition:Adopt a balanced diet that includes a variety of nutrient-dense foods, such as fruits, vegetables, whole grains, lean proteins, and healthy fats. Pay close attention to portion sizes and opt for high-fiber foods that can help regulate blood sugar levels and promote feelings of fullness.

Monitor Carbohydrate Intake:Carbohydrates can have a significant impact on blood sugar levels. Its crucial for individuals with diabetes to monitor their carbohydrate intake and choose healthier options such as whole grains, legumes, and non-starchy vegetables.

Prioritize Regular Physical Activity:Incorporate regular physical activity into your routine, aiming for at least 150 minutes of moderate-intensity aerobic exercise per week, along with strength training exercises twice a week. Physical activity helps improve insulin sensitivity, manage blood sugar levels, and support weight loss.

Set Realistic Goals:When trying to lose weight, its essential to set realistic and achievable goals. Aim for a gradual weight loss of about 1 to 2 pounds per week, which is more sustainable and less likely to negatively impact blood sugar control.

Seek Support:Losing weight can be challenging, so its crucial to have a strong support network. This could include friends, family, healthcare professionals, or even online communities and support groups. Sharing your experiences and goals with others can help you stay motivated and accountable.

Monitor Your Progress:Regularly track your progress, including changes in weight, blood sugar levels, and overall well-being. This information can help you and your healthcare team make necessary adjustments to your diet, exercise, and medication regimen to ensure optimal results.

Losing weight as a diabetic requires a balanced and individualized approach, focusing on proper nutrition, regular physical activity, and close monitoring of progress. By consulting with healthcare professionals and setting realistic goals, individuals with diabetes can achieve a healthier weight and improve their overall health.

Obesity is a complex condition that can be challenging to manage. In addition to lifestyle changes, such as diet and exercise, some individuals may benefit from long-term pharmaceutical intervention to help with weight loss. Here are some considerations regarding the use of weight loss medications for long-term management of obesity.Efficacy and Safety: Weight loss medications have varying degrees of efficacy and safety profiles. Its important to discuss the potential benefits and risks of long-term use of weight loss medications with a qualified healthcare provider, such as a physician or a registered dietitian. They can evaluate your individual health status, medical history, and weight loss goals to determine the most appropriate treatment plan for you.

Lifestyle Changes: Weight loss medications should be used in conjunction with healthy lifestyle changes, including a balanced diet and regular physical activity. Medications alone are not a magic solution and are most effective when combined with lifestyle changes for long-term weight management.

Monitoring and Follow-Up: Long-term use of weight loss medications may require ongoing monitoring and follow-up appointments with your healthcare provider. Regular check-ins can help track your progress, assess the effectiveness of the medication, and address any potential side effects or concerns.

Potential Side Effects: Like any medication, weight loss medications may have potential side effects. Its important to be aware of the possible side effects associated with the specific medication you are taking and report any unusual symptoms or adverse effects to your healthcare provider.

Individualized Treatment Plan: The most effective treatment plan for obesity may vary depending on individual factors, such as age, overall health, and medical history. A personalized and individualized approach, in consultation with a qualified healthcare provider, is essential to ensure the best outcomes.

Compliance and Adherence: Long-term use of weight loss medications requires compliance and adherence to the prescribed treatment plan. Its important to follow the prescribed dosage and instructions for use, and communicate any concerns or challenges with your healthcare provider to optimize the effectiveness of the medication.

Monitoring Mental Health: Some weight loss medications may have an impact on mental health, including mood changes or risk of depression. Its important to be aware of these potential effects and communicate any changes in mental health to your healthcare provider for appropriate management.

Lifestyle Factors: Lifestyle factors, such as stress, sleep, and emotional eating, can impact weight management outcomes. Addressing these factors and developing healthy coping strategies is crucial for long-term success in managing obesity, even with the use of weight loss medications.

In conclusion, long-term pharmaceutical intervention with weight loss medications can be a helpful tool in managing obesity, but it should be used in conjunction with healthy lifestyle changes and under the guidance of a qualified healthcare provider. Monitoring for potential side effects, compliance with the treatment plan, individualized approach, and addressing lifestyle factors are important considerations for long-term use of weight loss medications in the management of obesity. Regular communication with your healthcare provider is crucial for optimizing outcomes and ensuring safe and effective use of weight loss medications.

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Tips for Losing Weight as a Diabetic: A Balanced Approach - Diabetes In Control

Over the past few years, everyone has been talking about weight loss drugs. Although these injections aren't for everyone, it seems every other person who thinks about dieting also wants an easier solution and ends up switching over to these treatments.

It's been repeatedly discussed why these injections aren't exactly a panacea and why they aren't suitable for everyone. However, a recent study has found they might have a surprising and disturbing side effect.

The study in question, published in the peer-reviewed academic journal Diabetes Care, discovered a link between the long-term use of these treatments and one's risk of developing thyroid cancer. The study notes that people who used the drugs for one to three years were 58% more likely to develop thyroid cancer.

Thyroid cancers are considered relatively mild. It develops very slowly and sometimes doesn't cause any symptoms at all and only gets diagnosed randomly as part of neck imaging tests.

Common symptoms are hoarseness for no apparent reason that doesn't go away after a few weeks, as well as difficulty breathing or swallowing.

The current weight loss drugs on the market are sold as a treatment for obesity and have been used for years to treat diabetes. Researchers at the University of Montpellier in Vermont examined type 2 diabetes patients who were treated with these drugs between 2006-2018.

They found that yes, there was indeed a higher likelihood of developing thyroid cancer.

However, this is just one study. What's most likely ot happen is that it will add an additional routine test for people who take these drugs need to undergo.

Currently, weight loss drug treatment patients need to get their liver, diabetes levels, kidneys, cholesterol and electrolytes examined every three-four months. Currently, though, that doesn't include testing the thyroid.

Regardless, experts cautioned that these drugs should only be used when the benefits outweigh the risk, and even then the patient should see their doctor regularly.

However, it should also be noted that aside from a higher likelihood of developing thyroid cancer, these drugs have other side effects.

The most common ones that nearly all patients get are nausea, abdominal pain, diarrhea or constipation. However, these are mild and may even improve or disappear over time. Not only that, but they are dependent on the dosage, so the slower and more gradually your dosage increases, the less likely these will become severe.

There are other rare side effects that aren't dose-dependent, though. These include pancreatitis, which is an acute inflammation of the pancreas, and gallstone complications like cholecystitis, which is an acute inflammation of the gallbladder.

In Israel, there are two types of these drugs that are available for use. The first and older one is called Liraglutide, also known as Victoza or Saxenda. The second and newer one is called Semaglutide, also known as Ozempic.

These injections contain a synthetic hormone similar to a hormone our digestive system secretes after meals. This hormone, called GLP-1, links to specific receptors in the digestive system and brain, and has several effects.

Regarding the brain, it causes a decrease in appetite and a mental fixation on food. In the digestive system, it manages to stop the stomach from emptying as fast, which means the food stays in longer and you stay more satisfied from your food.

It also impacts the pancreas, which is responsible for secreting insulin for increased sugar levels, and the liver, which helps balance blood sugar levels.

Dr. Relly Reicher, a senior physician at the obesity and endoscopic bariatric unit at Sourasky Medical Center (Ichilov) in Tel Aviv, told Walla that medical treatment for obesity, including these drugs, can be prescribed to patients with a BMI of over 30 or over 27 if there are other obesity-related comorbidities.

"This isn't a technical matter. These have been the criteria to be included in clinical studies on obesity drug treatments for years," he said. "As part of these studies, thousands of patients were treated and monitored, which taught us about the drugs' effectiveness as well as the possible side effects and complications. There's no reliable and controlled information about the effect these drugs have on people with normal body weight and without underlying obesity-related conditions. Like any drug treatment, when the patient has no need for it, they are only left with the potential risks and side effects without any benefits."

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Weight loss drugs: Everyone wants them, but are they even safe? - The Jerusalem Post

While many people with overweight or obesity are able to lose excess weight through lifestyle interventions such as diet and exercise, it has long been recognized that it is challenging for many to keep this weight off.

Obesity is considered an epidemic by the World Health Organization (WHO), as over 4 million people are dying, as a result, each year. It is believed a lot of these deaths could be avoided with weight loss. For example, a weight loss of 5-7% has been shown to prevent or delay the onset of type 2 diabetes.

Unfortunately, as many as 80% of those who have lost weight through diet and exercise regain all of the weight they originally lost. Historically this weight gain has been blamed on a lack of self-control or failure to adhere to weight maintenance regimes.

The latest research offers a new explanation: in individuals with obesity who have recently lost weight, a higher level of the hormone neurotensin could be linked to a better ability to maintain this weight loss.

Their findings have been published in the journal Metabolism.

One theory to explain why people experience rebound weight gain has been that of set-point weight, the idea that the body will return to a set weight despite weight loss or gain.

Dr. Mir Ali, bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center, Fountain Valley, C.A.explained to Medical News Today:

The theory of set point weight is there is weight that your body wants to remain close to (give or take 5-10lb); many factors including age, genetics, sex, medical conditions and activity level can affect this set point.

The mechanisms that might be behind this observation, are unclear, however.

Despite the rise in the number of people with obesity starting in the 1970s according to the WHO, the role of hormones in appetite regulation has only become apparent in recent decades. Ghrelin, a hormone that increases the drive to eat, was only isolated and identified in 1999. It is now known to regulate appetite, fat storage, and energy regulation. It also interacts with other hormones involved in fat storage and energy regulation such as insulin.

Previous research has shown that ghrelin levels tend to rise after weight loss following diet and exercise, and researchers have proposed this could be a cause of rebound weight gain. Conversely, levels of this hormone decrease after bariatric surgery, which has a lower rate of rebound weight gain than diet and exercise-based interventions.

The interaction between ghrelin and leptin, a hormone that regulates satiety and energy regulation over the longer term, was discovered less than 20 years ago in 2004. Since then, leptin resistance has been found to exist in people with obesity, making them less sensitive to its appetite-quelling effects.

More recently, attention has turned to another hormone called neurotensin, and its potential role in weight gain after weight loss. This hormone is produced in the brain and gut. Previous research has shown that neurotensin levels increase after bariatric surgery, much like other hormones that regulate energy expenditure and appetite.

Dr. Gina Leinninger, associate professor of physiology at Michigan State University who researches the regulation of energy and its contribution to obesity in humans told MNT:

There has been growing interest in how neurotensin could modulate body weight. We knew from prior research that when animal models received neurotensin it could reduce their feeding and increase their locomotor activity dual behaviors that could support weight loss.

A group of researchers from Denmark has shown that in individuals who have recently lost weight, higher neurotensin levels after meals could be linked to how likely they are to maintain their weight. They also showed neurotensin levels decrease after weight loss in mice and people with obesity.

Researchers first put 9 obese mice on a calorie-restricted diet for 8 days and kept 8 obese mice on a normal diet to act as controls. After euthanizing the animals, the researchers took samples from four parts of the intestine the duodenum, jejunum, ileum, and proximal colonto look at the levels of neurotensin expressed in those areas.

The calorie-restricted diet in mice aimed to induce weight loss similar to that observed in the 8-week human study.

The researchers found the mice that had their food restricted had significantly reduced neurotensin concentrations in the jejunum part of the small intestine.

Next, researchers looked at the effect of a very low-calorie diet regime of around 800 calories a day for 8 weeks on a cohort of 42 obese patients. Participants lost an average of 12.3 kg following this intervention. At the end of this 8-week period, participants underwent testing to observe how their leptin, insulin, ghrelin, and neurotensin levels changed in the three hours after a meal.

Researchers then instructed this cohort to follow a calorie-restricted diet (600 calories less than their daily need), for a further 52 weeks.

To analyze the impact of hormones on weight loss maintenance, researchers analyzed findings for a subcohort of participants, from both groups, those who had lost over 3% weight during the maintenance period and those who had regained 5% or more of their initial weight loss.

They found that those who had initially shown a higher level of neurotensin in the three hours after a meal after the initial 8-week weight loss phase were more likely to have lost additional weight in the maintenance period.

Leptin, insulin, and ghrelin levels were not significantly different in either cohort.

The Metabolism paper is the first to link changes in circulating neurotensin to better/ sustained weight loss outcomes in humans, and suggest that (in the future), modulating the neurotensin system might be useful to help support and/or optimize weight loss. However, of course, there is much more to understand before that goal is achievable! Dr. Leinninger

Dr. Leinningers own research had been looking at which parts of the brain neurotensin affects, and if this plays a role in energy regulation and obesity. The next steps in research will center around that.

The next big questions are how neurotensin can control weight, and more specifically, where in the body it works. My lab has been exploring how and where in the brain neurotensin can modulate body weight and we have some good leads! she said.

Continued here:
Weight gain after losing weight: Researchers find hormonal link - Medical News Today

Diet guru Michael Mosley has revealed the best foods that can boost the metabolism and improve weight loss. The health expert is credited with founding several rapid weight loss diets that focus on intermittent fasting, also called time restricted eating, as well as high fat and low carb eating plans.

Such eating plans include the Keto diet and he also endorses the Mediterranean diet that's full of good fats and lean proteins. According to his ethos, Mr Mosley recommends eating foods like avocados, nuts, olive oil, chicken, and oily fish like salmon and mackerel.

Michael has created the the Fast 800 and 5:2 diets which he says are "safe and effective" for both short and long term weight loss, the Express reports. But many rapid weight loss plans have been slammed as crash diets that are ineffective after an initial burst of weight loss.

Other diets that follow similar patterns have been described as crash diets that sees slimmers quickly regain any lost pounds. However, the former doctor has defended his Fast 800 as being successful in the short and long term.

The former doctor has taken the time to defend his rapid weight loss diets and explained what makes other crash diets ineffective. Here's what you need to know.

The Fast 800 Keto builds on two diet trends - intermittent fasting and calorie restrictions, and the high fat, low carb keto diet. So is this another crash diet?

Michael responded: "Well, it's a rapid weight loss diet, which is not the same thing. A crash diet is something slightly crazy, unplanned, not based on science, like the cabbage soup diet.

"Whereas this is rapid weight loss diet based on a great deal of science and a number of studies carried outhave show that rapid weight loss - if done properly - can be much more effective and sustainable than slow and steady.

A keto diet consuming more high fat foods as they can help the body burn excess stores and shrink waistlines. In terms of the keto element to the Fast 800 diet, Michael explained: "Keto diet has been around for more than 100 years.

"It's a diet, broadly speaking, where you're eating a very low carbohydrate diet, less than 50g a day. And it's relatively high fat, and when you're doing that your body switches from burning sugar to burning fat.

"It does that by converting your fat stores into something called ketone bodies, which your body and brain then use as fuel. It's become very popular as a way of losing and keeping off weight, and that is largely because when you go into a state of ketosis, that suppresses a hunger hormone called ghrelin so you stop feeling hungry and stop having cravings.

"The disadvantage is that you're on a very high fat diet, which lots of people don't want to do and it isn't healthy in the long term. So what I'm proposing is rather a shorter term solution, which is combined with intermittent fasting and it's a relatively low calorie as well as a low carb diet. And that means you can eat a reasonable amount of healthy protein and fats - I describe it as a Mediterranean style diet."

Michael said adults need around 60g of protein a day - more if you're looking to lose weight. If you aren't eating this amount, "your body will cannibalise your muscles and your metabolic rate will go down" which means it is harder to lose weight or weight creeps back on.

The expert told Australia's RN Breakfast with Patricia Karvela: "If you do a safe and effective rapid weight loss diet, two to three years down the road you'll keep most of that weight off.

"So the idea that rapid weight loss is crazy, is just not true. Do it properly, and it can be very effective in the short, medium and long term. Indeed the amount of weight you lose in the first four weeks of a diet is the best a predictor of how long you'll keep the weight off for."

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Michael Mosley explains the 'rapid weight loss diet' and foods that help slimming - Daily Record

LeAnn Rimes marked her anniversary with husband Eddie Cibrian with an Instagram tribute video.

The singer shared a peek of her toned AF abs in a high-waisted bikini along with other shots of the couple over the years.

LeAnn is all about adaptable workouts that she can take on the road, like jumping rope.

Grab your tissue box. LeAnn Rimes just celebrated her 12-year anniversary with Eddie Cibrian, and she marked the occasion with the sweetest tribute video of all time.

In an Instagram post, LeAnn shared photos of the two of them as she counted back the years that they have been together and their ages in each one. The video starts with LeAnn looking super strong and happy while hanging on a boat with Eddie in a high-waisted bikini with toned abs. From there, the video counts back with photos of the two cuddling and kissing over the year.

The final shot is a total throwback: Its a picture of LeAnn and Eddie when she was 14 and he was 23.

12 years not a lot has changed, but the hair, she wrote in the caption. Happy anniversary to us @eddiecibrian. 12 years has FLOWN by so fast! our marriage, our love is one of the greatest gifts of this lifetime. im proud of us! People cheered them on in the comments. You both age like fine wine, or maybe a top tier TEQUILA, one said. Such a beautiful couple, another wrote.

LeAnn is so glowy and strong these days, and shes made it clear that she works hard to get super toned. A few weeks ago, she shared a video of herself at a drumboxing class, which is exactly what it sounds likea workout that involves drumming and boxing. Cut to a video of LeAnn and Eddie drumming and boxing, adding in things like squat jumps while drumming, following by throwing punches at a bag.

If youre looking for a new workout class that tests your brain as much as your body, go check out their page. we LOVE it here!! she wrote in the caption, before stressing that the post wasn't an ad.

Thats not ~all~ she does for fitness, though. LeAnn told Us Weekly that she loves jumping rope, especially on the road. I take a jump rope with me everywhere I go, so its easy to do and easy to do bodyweight workouts in my dressing room, she said. (In case youre not familiar with the perks of jumping rope, it can get your HR up fast.)

If she's not skipping, LeAnn previously told Womens Health that shell often jump on the trampoline for about 20 minutes in the morning, before working out with her trainer for about an hour. Talk about a cardio burst!

Of course, LeAnn travels a lot while she's on tour or on set, so she makes sure she is able to take her workouts on the road. In 2021, LeAnn shared a video in her Instagram Stories of herself squeezing in a dressing room workout that worked through a slew of moves. LeAnn got busy doing pushups with side twists, leg lifts with weight ball slams, tricep dips, and reverse squats with her foot on a chair.

On the food front, LeAnn told Womens Health that she just tries to find a healthy balance. She likes to kick her day off with Kimberly Snyders Glowing Green Smoothie, which has lots of chopped spinach, lettuce, celery, apple, pear, banana, and lemon juice. My body actually craves it, she said.

After a quick workout, LeAnn then says shell usually have leftovers from the night before for her lunch. Our leftovers range from mushroom and poblano tacos in almond flour tortillas, to smoky white bean and greens soup, to a delicious chicken and veggie stir fry, she said.

Dinner might be a bowl with cauliflower, lots of veggies, and marinated and baked tempeh or grilled chicken. Oh! And a glass of wine. LeAnn likes to nosh a little after dinner, too. "I am a bit of an after-dinner snacker," she said. "Barnana Dark Chocolate Banana Bites are my favorite treat, and I love an apple with a little peanut butter."

Overall, LeAnn just tries to do her best. Its all about balance, she said.

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Originally published April 24, 2023 at 10:13 AM

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LeAnn Rimes Is All Sculpted Abs In A Bikini In This Adorable Tribute IG Vid - AOL

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