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Mar 22

Neuroprotective Benefits of Exercise | National Parkinson …

What role does exercise play in the management of PD?

Exercise is an important part of healthy living for everyone. However, for people with PD exercise is not only healthy, but a vital component to maintaining balance, mobility and daily living activities. NPF is studying exercise in theParkinson's Outcomes Project.

Every NPF Center of Excellence agrees that they believe exercise is important to good outcomes in PD, and the data supports that. Exercising is associated with a better sense of well being, even across stages and severity of the disease. This was expected: there is a growing consensus amongst researchers about the short- and long-term benefits of exercise for people with PD.

Exercise can benefit in two ways:

What happens in the brain to produce these visible benefits? Researchers at the University of Southern California (Fisher et al.) looked at the brains of the mice that had exercised under conditions parallel to a human treadmill study. They found that:

Scientists at University of Pittsburgh found that in animal models, exercise induces and increases the beneficial neurotrophic factors, particularly GDNF (glial-derived neurotrophic factor), which reduces the vulnerability of dopamine neurons to damage.

At the molecular level, at least two things are happening to make dopamine use more efficient:

Many programs target the rapid gains that can be achieved through a focus on improvements in functional capacity and mobility. These programs vary according component activities. Examples of exercise programs for people with PD include:

YES! Everyone should exercise more, whether they have PD or not.

Page reviewed by Dr. Joash Lazarus, NPF Movement Disorders Fellow, Department of Neurology at Emory University School of Medicine.

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