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PHILADELPHIA, Oct. 28, 2020 (GLOBE NEWSWIRE) -- Scout Bio, a biotechnology company focused on revolutionizing pet medicine by delivering a pipeline of one-time therapeutics for major chronic pet health conditions, today announced it has initiated two pilot clinical studies to demonstrate effectiveness of an AAV expressing a GLP-1 analog (SB-009) in treating diabetic felines.

Scout Bio envisions two potential therapeutic applications for SB-009. First, to replace daily insulin injections with a single injection of SB-009 to treat feline diabetes and second to significantly increase the percentage of cats entering remission when SB-009 is given with insulin.

The two initiated pilot clinical studies will investigate each of these two potential treatment paradigms.

Mark Heffernan, Ph.D., Chief Executive Officer of Scout Bio remarked, This one-time injectable therapy for feline diabetes has the potential to provide a convenient single treatment that is an alternative to the burden of twice daily insulin injections. We believe SB-009 has the potential to be a blockbuster product for animal health and that our pipeline of gene therapy products for pets will disrupt and grow major markets.

SB-009 was developed under a collaboration between scientists at Scout Bio and the University of Pennsylvanias Gene Therapy Program, where the protein was engineered to improve potency, circulating accumulation kinetics and manufacturability. The design of SB-009 makes the clinical dose both affordable and commercially attractive.

Matthew Wilson, VP Product Discovery and External Innovation said, This is a further example of our strong collaborative relationship with UPenns Gene Therapy Program and Scouts internal capabilities of executing preclinical research to rapidly identify highly potent AAV gene therapies. In less than 12 months after initiating a discovery program, we are now in a position to transition into patients.

Scout Bio has conducted robust preclinical studies with various GLP-1 constructs in rodents and healthy cats. Key findings include:

Dr. Anne Traas, Scout Bios Chief Development Officer reflected, Owners can be devastated to learn their pet has this life-threatening disease and unfortunately, many are unable to give twice daily insulin injections and have to make the difficult choice to euthanize their beloved pet. A one-time safe and efficacious therapy, given by a veterinarian, that eliminates the need for insulin and worry of hypoglycemia, would greatly improve the current treatment paradigm and result in an improved quality of life for diabetic cats and their owners.

Feline diabetes, a severe disease lacking recent innovation, remains a major challenge for veterinarians and owners to safely and effectively manage. Diabetes in most cats is similar to type 2 diabetes in people. Insulin resistance, caused by factors such as obesity, leads to Beta-cell disfunction (the cells that produce insulin). Cats become insulin dependent when blood sugar levels rise, commonly 3-10 times normal, leading to the development of clinical signs which can seriously and negatively impact both the owner and the cat. The most common signs are increased drinking, increased urination and weight loss despite ravenous appetite.

About SB-009 SB-009 is a recombinant AAV gene therapy viral vector utilizing a novel capsid expressing an engineered feline GLP-1 agonist for the treatment of feline diabetes. GLP-1 has been shown to be a safe and highly efficacious molecule in the treatment of humans with type 2 diabetes and SB-009 is the first gene-therapy delivered GLP-1 to be studied in clinical studies in cats with a view to treat the disease.

The expressed feline GLP-1 analog protein functions by stimulating the beta-cells in the pancreas to produce more insulin and may also have an effect in decreasing insulin resistance. GLP-1 receptor agonists do not decrease glucose levels in animals with normal blood glucose, so there is expected to be a very low, or no risk of hypoglycemia.

About Feline DiabetesMost diabetic cats appear to have disease similar to human type 2 diabetes, which is primarily defined as a combined problem with insulin production by the beta-cells in the pancreas, as well as a decrease in the sensitivity to the normal action of insulin (insulin resistance). In cats, one of the most common factors contributing to insulin resistance is obesity which reduces insulin sensitivity.

Lack of insulin production and decreased sensitivity to insulin causes the glucose (sugar) in the blood to become very high leading to the clinical signs. Very high levels of blood glucose also hurt the beta-cells in the pancreas, leading to further reductions in insulin production.

Substantial progress has been made in the treatment of human type 2 diabetes, even in the early stages of the disease. However, insulin therapy remains the only FDA-approved treatment for diabetes in cats.

About Current Treatment | Feline DiabetesCurrent therapy aims to replace the insulin that the cats body no longer makes by injecting insulin twice daily. Giving insulin in the right amounts may bring the blood sugar levels down. If the blood glucose can be brought under control for the majority of a 24-hour period each day, then the clinical signs will be reduced to manageable levels. Too much insulin can cause the blood sugar to drop to dangerous levels (hypoglycemia), so there has to be a careful balance made between maintaining ideal blood glucose levels andadministering too much insulinwhich may result in life threatening low blood sugar levels.

Often owners find the prospect of administering injections to their cats daunting and the strict regimen of twice daily injections and feedings can be difficult to fit into a busy lifestyle. Unfortunately, not treating the cats is simply not a viable option and usually results in a rapid decline in physical health. Even with insulin treatment, some cats diabetes is not well controlled, resulting in the continuation of clinical signs and/or euthanasia.

About Diabetic RemissionGood control of blood glucose may also allow the beta-cells to rest. That rest may increase their capacity to regain some of their insulin-secreting ability. Insulin administration helps to decrease and control the excess blood glucose levels and complement whatever insulin producing ability the cat has left. In some cases, cats regain enough function to allow the insulin injections to stop. This is called diabetic remission. A cat is determined to be in remission when blood sugar is normal and there is complete correction of clinical signs once insulin has been discontinued.

About Scout BioScout Bio is a biotechnology company focused on revolutionizing pet medicine by delivering a pipeline of one-time therapeutics for major chronic pet health conditions. Scout Bios therapeutics are designed to induce long-term expression of therapeutic proteins in pet patients using AAV vector technology. Scout Bio has an exclusive research and development collaboration with the University of Pennsylvanias Gene Therapy Program. Scout Bios innovative partnerships build on a 20-year history with AAV leaders and is complemented by Scout Bios global leaders in gene therapy research and development. Scout Bio is a private company headquartered in Philadelphia, Pennsylvania. For more information, see http://www.scoutbio.coFor further information, please contact:

Investors:Sarah McCabeStern Investor Relations, Inc.212-362-1200sarah.mccabe@sternir.com

Media:Fran Gaconnier214.417.4142Fran.gaconnier@scoutbio.co

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Scout Bio Advances Novel Gene Therapy for the Treatment of Feline Diabetes - BioSpace

By Stephanie Bowens| StarNews Correspondent

Polycystic Ovary Syndrome is one of the most common, yet treatable, causes of infertility in women. PCOS affects 1 in 10 women of childbearing age, according to the Office On Womens Health, and women who have the condition experience hormonal imbalance and metabolism problems that may affect their appearance and overall health.

Dr. Nicholas Bodenheimer, DO, an obstetrician-gynecologist withNovant Health OB/GYN Bolivia, said hes treated many women who have PCOS. He said the condition is typically characterized by hyperandrogenism, or elevated levels of androgens, such as testosterone, irregular or no menstrual periods and polycystic ovaries revealed on an ultrasound. Bodenheimer said despite the name, you dont have to have polycystic ovaries or small cysts on yourovaries to be diagnosed with PCOS. He recommends women discuss their concerns with a gynecologist.

1. Imbalances of hormones, including insulin and testosterone, play key role in PCOS symptoms.

The exact cause of PCOS is unknown. However, PCOS is associated with insulin resistance, obesity and high levels of androgens.

Androgens, often called male hormones, are hormones, such as testosterone, that are important for normal male sexual development, but women also make small amounts of androgens. Androgens control development of male traits, and women with PCOS have more androgens than normal.

Normally, in healthy women testosterone is largely bound by a protein called sex hormone binding globulin, leaving just a very small amount of freely circulating bioactive free testosterone. However, insulin resistance can disrupt this, and Bodenheimer said many women with PCOS have insulin resistance. Insulin resistance can cause a low level of sex hormone bind globulins, Bodenheimer said. So, if you have a low level of that you have an increase of testosterone in the body which can lead to hyperandrogenism.

Insulin resistance refers to when the bodys cells do not respond normally to insulin, a vital hormone that regulates blood sugar (glucose) in the body.

2. Irregular menstrual cycles are common symptoms of PCOS.

Higher than normal androgen levels in women can prevent the ovaries from releasing an egg (ovulation) during each menstrual cycle.

Bodenheimer said PCOS symptoms that often bring patients in to see him include excessive facial hair growth, absence of a menstrual period, irregular menstrual bleeding, or unsuccessfully trying to get pregnant for over a year. We see a lot of different types of clinical manifestations from PCOS, but probably the most common we see are menstrual disorders, Bodenheimer said. That can range from irregular menstrual periods to heavy menstrual periods to someone who is not having any menstrual periods. If we see women who are anovulatory, meaning they arent having regular menstrual cycles, that can lead to infertility.

Bodenheimer said usually in a 28-day cycle around cycle day 14 a woman ovulates so an egg is released. If someone is not ovulating, the egg is not released, he said. Thats how that leads to infertility.

Bodenheimer said there are various treatment options for infertility caused by PCOS.

3. PCOS often causes abnormal hair growth.

Bodenheimer said, for women with PCOS, increased levels of testosterone in the body can lead to excessive hair growth on their arms and face as well as acne. According to OWH, the excessive hair growth is called hirsutism and affects up to 70 percent of women with PCOS, causing them to have too much hair on the face, chin, or parts of the body where men usually have hair, and acne can appear on the face, chest, and upper back.

According to the OWH, other symptoms of PCOS include thinning hair, hair loss on the scalp or male-pattern baldness, weight gain or difficulty losing weight and darkening of skin, particularly along neck creases, in the groin, and underneath breasts.

4. Research has linked PCOS to other health problems, such as hypertension and sleep apnea.

According to OWH, studies have found links between PCOS and diabetes, high blood pressure and unhealthy cholesterol, sleep apnea, depression and anxiety and endometrial cancer. OWH indicates more than half of women with PCOS will have diabetes or prediabetes before age 40, and women with PCOS are at higher risk for high blood pressure compared with women of the same age without PCOS.

Problems with ovulation, obesity, insulin resistance, and diabetes, which are all common issues in women with PCOS, increase the risk of developing endometrial cancer, according to OWH.

Additionally, Bodenheimer said, For women with PCOS who do get pregnant we see increased risk of gestational diabetes as well as hypertensive disorders such as preeclampsia.

5. PCOS treatment focuses on managing symptoms.

Bodenheimer said treatment for PCOS focuses on treating and managing patients symptoms. When developing a treatment plan, the physician typically considers the patients symptoms, their plans for having children, and the patients risk of long-term health problems such as diabetes and heart disease.

If patients desire future fertility and are planning to become pregnant, then we see if they are ovulating or not, and we can usually do that by checking lab work, he said. If we are treating someone with PCOS who is not ovulating, we can treat them with medicine to help them ovulate, he said.

But Bodenheimer said one of the risks of using fertility drugs include pregnancy with multiples, such as twins.

If they are not desiring fertility in the immediate future, then we try things like birth control pills to help regulate those menstrual periods, Bodenheimer said.

He said he also sometimes discusses lifestyle modifications, including diet and weight loss. Some studies show losing five to 10 percent of their current body weight may induce spontaneous ovulation again, he said.

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5 things to know about Polycystic Ovary Syndrome - StarNewsOnline.com

Oh, January the month of the clean slate. The kick-off of a new year is certainly the most popular time for making resolutions, forging fresh starts, and going dry.

In case you arent familiar with the basics of Dry January: Its when someone decides to go the whole month without consuming any alcohol. Thats right not a drop.

Cutting back on alcohol consumption at the start of a new year has been an increasingly popular trend. And with 1 in 5 Americans participating in Dry January 2019 and the #DryJanuary hashtag showing up in nearly a quarter of a million social posts at the time of this article, it shows no sign of slowing.

Theres no shame in wanting a break from booze or at least a reset with improved health habits in mind. But participating in Dry January the right way takes a plan.

The term Dry January was registered as a trademark by the British charity Alcohol Change UK in 2014. The campaign had kicked off in 2013 to great success. Alcohol behavior expert Dr. Richard de Visser surveyed participants of the first Dry January and found that 7 out of 10 continued with safer drinking practices 6 months after the campaign ended.

From there, Dry January took off. In 2015, Alcohol Change UK partnered with Public Health England, which started the craze that would lead to Dry January being recognized worldwide.

Were not gonna lie: Dry January has a mixed reputation. A quick Google search will generate just as many negative experiences as positive ones. And your participation in Dry January may come with differing opinions from your inner circle.

But, as with most things in life, all that really matters is whether Dry January is the right choice for you.

Theres evidence that going alcohol-free for a stretch can bring financial savings and weight loss in addition to health benefits. The first step is determining what your goals are.

A survey of 800 Dry January participants found that the alcohol-free month led to financial savings (for 88 percent of those surveyed), a better sense of control (80 percent), improved sleep (71 percent), increased energy (67 percent), and weight loss (58 percent), among other effects.

If you rarely drink alcohol, you may not notice many immediate benefits of Dry January (other than crushing a goal!). But it can have a major upside if you typically drink more than the recommended limit of one drink per day for women and two for men even if you go beyond this number only occasionally.

One of the first things you may notice after participating in Dry January is increased focus, since high levels of alcohol consumption are related to decreased mental performance. According to a 2009 research review, heavy social drinkers may have difficulty recalling verbal or visual information.

Plus, since alcohol is a depressant, going booze-free can have positive effects on mood and mental health. This is especially good in January to help combat those winter blues.

Saying so long to alcohol means saying so long to hangovers and the headaches, nausea, dehydration, mood changes, and other negative effects they might cause.

You may also notice that youre sleeping better in general. Alcohol is a common culprit for sleep disruptions, and studies have shown that it can decrease sleep quality by as much as 39.2 percent.

Dry January can also come with some immune system benefits, which are always more than welcome in the middle of winter. Research shows that drinking alcohol directly suppresses the immune system and increases the risk of infectious diseases.

In terms of more long-term benefits, avoiding alcohol for only 30 days may not come with substantial changes. But its a great reset and an opportunity to be extra mindful, which can lead to healthier drinking habits in the future.

Dry January-ers also commonly report weight loss. Alcohol (especially sugary mixed drinks) can be very high in calories, since it contains 7 calories per gram almost as many as a gram of fat.

Alcohol provides your body with calories but barely any nutrients. In a 4-year study of nearly 5,000 people with diabetes and higher body weights who were trying to lose weight, alcohol consumption was associated with less weight loss.

High alcohol consumption is linked to cardiovascular disease and cancer, so developing healthier drinking habits is always a good thing when it comes to your overall health.

Abstaining from alcohol also gives your liver some much-needed relief. In 2013, the staff of New Scientist conducted a small study and found that participating in Dry January reduced liver fat by 15 percent. But more research is needed to confirm the specific benefits.

Dry January isnt for everyone. If you feel that you may have a larger issue with alcohol consumption, stopping cold turkey is not recommended, as it can come with withdrawal symptoms. In that case, its best to seek professional help with your approach.

Otherwise, there are plenty of tips and ways to safely and easily participate in Dry January.

Just as your body needs to be conditioned for a race, it also needs to be conditioned to go without alcohol. Once you commit to participating in Dry January, try to avoid heavy or binge drinking beforehand. Let others know what youre doing so you have some accountability.

Speaking of accountability, it helps to rally some friends who are curious about Dry January and want to participate alongside you. Join some Facebook groups or connect with others using the hashtag #DryJanuary.

Realistically, it probably wont be easy. There will be temptations during the month. But you can avoid triggers by tweaking some decisions here and there.

This doesnt mean you have to stop being social it just means you have a chance to get creative. Instead of heading to the bar, take time to visit a museum, learn something new, have movie or craft nights, or work out with friends.

There are plenty of other beverages to drink while socializing that feel fun, like creative alcohol-free cocktails, CBD drinks, or kombucha. Many people find that carbonated drinks are more fun than the plainer options like water (just opt for the low-sugar options).

Understand that its OK to say no. Sure, it may seem awkward at first to be sober around your friends while theyre drinking, and they may not fully understand your choice. But thats OK. You can stand firm in your decision and give yourself the space to see the process through. You are in control.

Participating in or successfully completing Dry January is an accomplishment in itself and one that can lead to healthier habits, more control, and better responses to peer pressure. But no one says you have to stop there. If you choose to, you can take the benefits far beyond the 31-day challenge and into the rest of your year.

Carrying forward what you like from your experience is completely within your control, but will take continued planning and consistency. If you want to push your plan to 2 months, 6 months, or longer, you have a blueprint to follow. If you simply want to make Dry January an annual tradition, you know how to approach it from a prep standpoint.

Also, maintaining the support system youve formed is vital. Even if you dont want to make it a whole dry year, any progress you strive for will be easier with support.

Bottom line: If youre considering a break from alcohol, Dry January can provide perspective on your relationship with alcohol and the role it plays in your life.

Continued here:
Dry January: How to Participate and What It Means for Your Health - Greatist

Dear Savvy Senior,

Can you write a column on how to recognize elder abuse and what to do if you suspect it? Concerned Relative

Dear Concerned,

Elder abuse is a big problem in the United States that has escalated during the COVID-19 pandemic. According to the National Council on Aging, as many as five million seniors are victims of abuse each year, but studies suggest this crime is significantly under-reported. Only one in 14 cases of elder abuse ever gets reported to the authorities because victims are usually too afraid, too embarrassed, too helpless or too trusting to call for help.

The term elder abuse is defined as intentional or negligent acts by a caregiver or trusted individual that cause or can cause harm to a vulnerable senior. Elder abuse also comes in many different forms: emotional, psychological, physical or sexual abuse, abandonment, neglect and self-neglect, and financial exploitation.

Those most vulnerable are seniors that are ill, frail, disabled, socially isolated or mentally impaired due to dementia or Alzheimers disease.

Its also important to know that while elder abuse does happen in nursing homes and other long-term care facilities, the vast majority of incidents take place at home where the senior lives. And tragically, the abusers are most often their own family members (usually the victims adult child or spouse) or caregiver.

How to Recognize Abuse

So, how can you tell if an elderly relative or friend is being abused, and what can you do to help?

A change in general behavior is a universal warning sign that a problem exists. If you notice that your relative or friend has become very depressed, withdrawn or gets upset or agitated easily, you need to start asking questions. Here are some additional warning signs on the different types of elder abuse that can help you spot a possible problem.

Physical or sexual abuse: Suspicious bruises or other injuries that cant be explained. Sudden changes in behavior (upset, withdrawn, fearful). Broken eyeglasses. Caregivers refusal to allow visitors to see an elder alone.

Neglect or self-neglect: Weight loss, poor hygiene, unattended medical needs, and unsanitary, unsafe living conditions.

Emotional or psychological abuse: The senior is extremely upset, agitated, withdrawn, unresponsive, fearful or depressed, or demonstrates some other unusual behavior.

Financial exploitation: Missing money or valuables. Unexplained withdrawals from bank accounts, or transfers between accounts. Unauthorized use of credit, debit or ATM card. Unpaid bills despite available funds. Checks written as a loan or gift. Abrupt changes in a will or other documents.

For more tips on how to recognize the warning signs of abuse during the pandemic, see the National Center on Elder Abuse website at NCEA.acl.gov/Resources/COVID-19.aspx.

What to Do

The best ways to help stop elder abuse is to be in touch and keep the lines of communication open. If you suspect any type of abuse or neglect in your relatives or friends home, report it to your local protective services agency.

Adult Protective Services is the government agency responsible for investigating elder abuse cases and providing help and guidance. Call the Eldercare Locator at 800-677-1116 to get the agency contact number in your area or visit NCEA.acl.gov/Resources/State.aspx.

The agency will ask what you observed, who was involved, and who they can contact to learn more. You dont need to prove that abuse is occurring; it is up to the professional.

Or, to report suspected abuse in a nursing home or assisted living facility, call the local Long-Term Care Ombudsman see LTCombudsman.org for contact information.

If, however, you feel the person is in immediate danger, call 911 or the local police for immediate help.

Send your senior questions to: Savvy Senior, P.O. Box 5443, Norman, OK 73070, or visit SavvySenior.org. Jim Miller is a contributor to the NBC Today show and author of The Savvy Senior book.

The Gazette does not endorse the contents of The Savvy Senior. Check with professionals about the contents of this column.

Original post:
How To Recognize And Stop Elder Abuse In The COVID Era - Western Queens Gazette

What is the recommended rate of weight loss on a long term basis for most overweight people?

0.5-2 lbs/week is a safe rate of weight loss on a long-term basis for most overweight people.

Losing even more weight is associated with greater health benefits, so the guidelines recommend that people start out with a goal of losing 5 to 10 percent of their body weight over six months. To accomplish this weight loss, most experts interviewed by Live Science recommended that you shed 0.5 to 2 lbs.

According to many experts, losing 12 pounds (0.450.9 kg) per week is a healthy and safe rate (1, 2 , 3 ). Losing more than that is considered too fast and could put you at risk of many health problems, including muscle loss, gallstones, nutritional deficiencies and a drop in metabolism (4, 6 , 7 , 8).

The Health Effects of Overweight and Obesity

Weight-loss specific behaviors associated with long term success include: frequent self-monitoring and self-weighing, reduced calorie intake, smaller and more frequent meals/snacks throughout the day, increased physical activity, consistently eating breakfast, more frequent at-home meals compared with restaurant and

The bottom line

Some of the most well-researched diets and eating plans include intermittent fasting, plant-based diets, low-carb diets, low-fat diets, the paleo diet, the Mediterranean diet, WW (Weight Watchers), and the DASH diet.

The takeaway. You should only conduct a 500-calorie diet under a doctors close supervision. Though you may lose weight, you are at risk of malnutrition, which can cause many health problems.

Below are strategies to help you approach weight management with a more positive and productive mindset.

But many doctors agree that a medical evaluation is called for if you lose more than 5 percent of your weight in six months to a year, especially if youre an older adult. For example, a 5 percent weight loss in someone who is 160 pounds (72 kilograms) is 8 pounds (3.6 kilograms).

Unintentional weight loss does not always have an identifiable underlying cause but, in addition to the causes already mentioned, its often the result of: depression. an overactive thyroid gland (hyperthyroidism), or over-treating an underactive thyroid. cancer.

Well, here are some ways to indicate if youve gained or lost weight without using the weighing scale.

No, you cannot. For you to lose 1 pound of fat (or 0.4 kilograms) a day, you have to burn about 3500 calories (5). As a general rule, women and men require 2000 and 2500 calories, respectively, each day (20). To lose any extra weight, you need to cut about 500 to 1000 calories from your average.

Yes, according to a new study showing people whore even a little overweight face increased risk for many serious diseases, including diabetes, heart disease, colon cancer, high blood pressure, and gallstones. Its very important to take obesity seriously and intervene before people become overweight.

People can be obese yet physically healthy and fit and at no greater risk of heart disease or cancer, according to BBC News. This counterintuitive headline stems from a study that was assessing health outcomes for people who were obese but relatively fit, with only one or no risk factors for metabolic syndrome.

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What is a safe rate of weight loss on a long-term basis ...

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Weight Loss and Obesity Management Market to Witness Robust Expansion Throughout the Forecast Period 2018-2028 - Eurowire

Medical device companies continue to grapple with near-term uncertainty as COVID-19 rages on, impacting some regions more so than others. This uncertainty was apparent during Intuitive Surgical's third-quarter earnings call. The surgical robotics pioneersawsignificant variability in procedure growth and new system placement pipelines by region.

"While the pandemic has created near- and mid-term uncertainty in the form of competing healthcare priorities and economic stresses, I have high confidence in the need for high quality, minimally invasive surgery and therapies in long-term," Intuitive Surgical CEO Gary Guthart said during the call."To deal with the current and future stresses on the healthcare system, payers, hospitals, and surgeons are looking for solutions that improve outcomes, decrease in hospital resource consumption, and lower total cost to treat. In other words, the core pillars of the quadruple aim we had set as our goal many years ago."

Intuitive installed 195 new surgical robotics systems during the quarter, which is significantly weaker than the 275 installs the company saw in Q3 2019, but an improvement over the 175 installs seen in Q2 2020. That's a 29% decrease year-over-year, and a 10% increase from last quarter.

CFOMarshall Mohr provided additional color regarding procedure trends the robotics company has seen in recent months. Overall, Mohr said, Intuitive's robotics procedures recovered gradually during the third quarter, exiting the quarter at around 90% of pre-COVID levels. However, he noted, the extent and pace of recovery varied by market.

The U.S. market did experience broader adoption across multiple robotics procedures led by general surgery. For example, Mohr said, Intuitive saw significant year-over-year growth in bariatric procedures, but that growth was partially offset by reduced diagnosis of conditions such as prostate cancer, which impacted procedure volumes in those areas.

Philip Kim, head of investor relations at Intuitive, pointed out that bariatric procedures may have benefited from some patients prioritizing weight loss during the pandemic because obesity has been identified as a COVID risk factor.

"While total worldwide procedure rates have improved, it is possible that resurgences of COVID-19 like those currently being experienced in parts of Europe and the U.S. could negatively impact da Vinci procedures," Mohr said."In addition, delays in diagnosis and treatment of underlying conditions could also negatively impact da Vinci procedures."

Guthart did note that hospitals seem to be doing a better job of handling concurrent needs of COVID and non-COVID patients compared to the early days of the pandemic.

"I think they have protocols that they feel good about," Guthart said."I think they have access to resources and things like PPE that early on they didnt. That gives us some comfort that, barring a massive influx, they can manage both [sides] of patient need."

He also said hospitals are showing a clear interest in minimally invasive surgery and in Intuitive's robotics products. But that doesn't necessarily give the company or its investors any more visibility into the next few quarters.

"What the weather does, what the COVID pandemic does, I think, it is harder for Intuitive to have direct insight into," Guthart said.

This lack of insight made some medtech analysts hesitant to issue a "buy" rating on Intuitive.

"While we continue to believe that the long-term thesis for [Intuitive Surgical] remains intact, the lack ofvisibility into near-term trends makes it hard for us to recommend shares at the current valuation," noted Ryan Zimmerman, a medtech analyst at BTIG. The firm maintained its "neutral" rating on Intuitive's stock.

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Intuitive Is Upbeat on Long-Term, Cautious on Near-Term - Medical Device and Diagnostics Industry

ALLEN PARK -- Matt Nelson had other offers to play defensive line after going undrafted out of Iowa last year. But the Detroit Lions had a long-term plan for the 6-foot-8 defensive lineman, and it involved a lot of trust, patience and eating to make it a reality.

Nelson, who saw 46 snaps at right tackle in Detroits win last week, said the long-term vision was the selling point to sign with the Lions despite some offers to stay put. Nelson was a four-year defensive lineman at Iowa, racking up 109 total tackles, 11 for loss and eight sacks in 43 games.

It was really just a Detroit thing, Nelson said via Zoom on Thursday. "They reached out to me in the predraft process and were like: Hey, we dont really see you as a defensive lineman. Would you mind switching over to the offensive line? And kind of went over like the barebones plan of, OK, youre going to come in, essentially redshirt you. We dont see you playing at all the first year. Were going to put some weight on you. Youre going to learn how to play offensive line, and essentially go from there.

I had one or two other offers to play defensive line, and essentially, it was like, OK, this (offensive line) is my best opportunity to keep playing football for a long time. After talking with family, my agent, and everything like that, it was like OK. Theyve got a plan for, they are really willing to invest in you. I think we should do it. I think its worked out great so far.

He was granted the extended playing time due to Lions offensive tackles Tyrell Crosby and Halapoulivaati Vaitai exiting due to dehydration issues in Jacksonville. Nelson had seen the occasional rep as the extra lineman or on special teams this season, but this was his first taste of an actual role.

Related: The Lions' decision to convert ex-Iowa DE Matt Nelson into an offensive tackle pays off

Nelson played some tight end in high school but said Week 6 represented the first time he had blocked anyone since. He allowed two pressures, but the Lions ran for 180 yards and three touchdowns in the win, so not too shabby.

He said he came into Allen Park a little under 295 pounds last year and was told by former offensive line coach Jeff Davidson there would be no playing while tipping the scales under 300 pounds. So, Nelson spent the year eating, lifting weights and learning how to play offensive line on Detroits practice squad.

He said he definitely feels bigger and more like an offensive lineman after gaining 15 pounds, undergoing a body transformation.

It just felt like I was snacking all the time, he said. "There were probably three or four solid meals, but before practice, a peanut butter and jelly sandwich and a shake -- that sort of stuff. Eating was my job at that point in my life.

I came in at a little bit under 295 and the coach last year, (former Lions offensive line) coach (Jeff) Davidson was like, Im not going to put an offensive lineman out there under 300 pounds. And so, hes like, 'OK, youre going to have to gain weight. Youre going to have to gain strength in your core, your upper body. Essentially said, 'OK, you need to build up your body, so I met with Jeff and the coaching staff, and they essentially came up with a plan where I lifted four days a week.

While making the switch from defensive to offensive line doesnt sound ideal for someones initial professional prospects. Nelson said he wouldnt have it any other way because he might not have sniffed the field had he made the switch while at Iowa. Hes certainly not wrong in that way of thinking, with Iowas standing as a bonafide offensive line factory still holding firm.

So when I got there, Brandon Scherff and Andrew Donnal were the tackles. And then when I was a young player, it was Ike (Ike) Boettger and Boone Myers. Ike is still in the league. He plays for the Bills, and Boone was a very good tackle, Nelson said. "Then, when I was leaving, it was Alaric Jackson, who is there currently, and (Buccaneers first-round rookie tackle) Tristan Wirfs.

I dont think I would have ever played. I mean, Ive talked to them about it, and they were like, yeah, we thought about putting (you) at tackle, but we needed you on the defensive line. It was just the fit at the time. And I honestly dont know if I would have beat any of those guys out, but Im kind of glad it happened the way it did.

Its worth noting this long-winding journey to Detroits offensive line wouldnt have occurred had it not been for sound advice from his future wife while the two were in high school. Nelson was apparently toying around with the idea of focusing on basketball due to some offers from mid-majors, the Dakota schools (and) Rice.

My wife was the big one that essentially was like, Youd be stupid if quit football. And Im glad she told me that because I wouldnt be here, Nelson said. "From early on, shes always been very, very truthful and very, very blunt with me. At one point, I did think I was a great basketball player, but reality set in, and football was for me.

Yeah, my first Division I interest was from basketball schools. Thats why I thought I was good at basketball, but yeah, I got a big reality check when it turned out theres not a lot of 6-foot-8 white dudes in the NBA.

KCRG-TV in Cedar Rapids reports Nelson and his wife, Hayley, held a virtual wedding over the summer.

Related: Joe Dahl plays vital role in offensive lines impressive day in return from injury

While the Lions sold Nelson on their long-term plans, the newfound offensive lineman maintains goals for life post-football. He worked in an orthopedic and neurosurgery research lab while at Iowa and continues to do his best to stay updated on current research trends.

Lions guard Joe Dahl revealed some of Nelsons doctoral aspirations during his media availability earlier this week. Dahl talked about the job Nelson had done with the transition, saying hes always asking questions and learning with an impressive work ethic.

Ive always been interested in science ever since I was little. I either wanted to play football or I wanted to be a doctor, Nelson said. I wanted to actually be an orthopedic surgeon. For the longest time, I wanted to be a team doctor, so if I could be like a team doctor in the NFL, like that would be sweet. Throughout life, Ive always wanted to be involved with sports and all that sort of stuff, and that was another avenue to do that. I definitely realize football is going to end at some point, and so what else interested me? I wanted to be a doctor, so yeah, I took the MCAT and other stuff. Had an interview at the University of Iowa for med school, didnt get accepted, but well see how long this football thing lasts and if I go back.

Related: New OL coach Hank Fraley one of the unsung heroes of season

Original post:
Matt Nelson declined offers to stay on defense due to Lions' long-term vision on offensive line - MLive.com

Earlier this month, Ohio Department of Health (ODH) Interim Director Lane Himes signed an order that allowed nursing homes to resume indoor visitation on Oct. 12 as long as the facilities met specific health and safety requirements. However, as of this week, no Highland County nursing homes will resume indoor visitation.

According to the latest order, which is the fifth iteration of a March order that limited access to long-term care facilities, nursing homes must consider the following when preparing to resume indoor visitation:

* The number of new and active cases in the surrounding community;

* The number of new and active cases in the nursing home;

* Staffing levels;

* Access to adequate testing for residents and staff members;

* Personal protective equipment supplies;

* Local hospital capacity.

The order also requires that once a nursing home resumes indoor visitation, it must screen visitors and require visitors to wear masks.

Due to the increase in new cases in Highland County, Laurels of Hillsboro Administrator Jo Sanborn told The Times-Gazette that the Laurels will not resume indoor visitation at this time.

Heartland of Hillsboro Admissions and Marketing Director Ashley Poole also told The Times-Gazette that Heartland is not open for visitation at this time, though she added, We hope to eventually have visitation, but we have no set date yet.

A representative of Crestwood Ridge Skilled Nursing & Rehabilitation told The Times-Gazette that Crestwood is not starting [visitation] immediately.

In Greenfield, Edgewood Manor Administrator Pierre Sweeney told The Times-Gazette that Edgewood is not currently able to offer indoor visitation, but loved ones may make an appointment for outdoor visitation by calling 937-981-2165. Outdoor visitors must undergo screenings at the nursing home prior to their scheduled visits.

According to a representative of Greenfield Skilled Nursing and Rehabilitation, the facility is also not allowing indoor visitation at this time.

Highland County Health Commissioner Jared Warner told The Times-Gazette in a Wednesday email, The health department provides regular input and support for nursing home visitation policies as each nursing home does their best to comply with the states visitation order. It is a difficult balance to find, because we all recognize how important it is to be with the people that we love in these nursing homes, but we also recognize the potential COVID-19 risks of indoor visitation.

A press release from Ohio Gov. Mike DeWines office stated, This order also details compassionate care visits, which are separate and distinct from normal visitation. These visits are not exclusively for end-of-life situations, but can also include situations where a resident was recently admitted to the home and are struggling with the change in environment and lack of family support.

Other situations can include when a resident is grieving someone who recently passed away, a resident that may need encouragement to eat or drink that was previously provided by a family member or caregiver and is experiencing weight loss or dehydration, or when a resident is experiencing emotional distress.

Once visitation resumes at Highland County nursing homes, the most recent health order requires nursing homes to limit visits to a maximum of 30 minutes with two visitors per resident. Visitors will be required to maintain social distancing and wear a face covering.

Loved ones will be required to schedule visits ahead of time, and the visits will take place separately from the residents rooms.

To read the full document, visit coronavirus.ohio.gov.

Reach McKenzie Caldwell at 937-402-2570.

Warner: It is a difficult balance to find

Read the rest here:
Local nursing homes currently not open to visits - Hillsboro Times Gazette

Dear Savvy Senior,

Can you write a column on how to recognize elder abuse and what to do if you suspect it?

Concerned Relative

Dear Concerned,

Elder abuse is a big problem in the United States that has escalated during the COVID-19 pandemic. According to the National Council on Aging, as many as 5 million seniors are victims of abuse each year, but studies suggest this crime is significantly under-reported. Only 1-in-14 cases of elder abuse ever get reported to the authorities because victims are usually too afraid, too embarrassed, too helpless or too trusting to call for help.

The term elder abuse is defined as intentional or negligent acts by a caregiver or trusted individual that causes or can cause harm to a vulnerable senior. Elder abuse also comes in many different forms: emotional, psychological, physical or sexual abuse, abandonment, neglect and self-neglect, and financial exploitation.

Those most vulnerable are seniors that are ill, frail, disabled, socially isolated or mentally impaired due to dementia or Alzheimers disease.

Its also important to know that while elder abuse does happen in nursing homes and other long-term care facilities, the vast majority of incidents take place at home where the senior lives. And tragically, the abusers are most often their own family members (usually the victims adult child or spouse) or caregiver.

How to Recognize Abuse

So, how can you tell if an elderly relative or friend is being abused, and what can you do to help?

A change in general behavior is a universal warning sign that a problem exists. If you notice that your relative or friend has become very depressed, withdrawn or gets upset or agitated easily, you need to start asking questions. Here are some additional warning signs on the different types of elder abuse that can help you spot a possible problem.

Physical or sexual abuse: Suspicious bruises or other injuries that cant be explained. Sudden changes in behavior (upset, withdrawn, fearful). Broken eyeglasses. Caregivers refusal to allow visitors to see an elder alone.

Neglect or self-neglect: Weight loss, poor hygiene, unattended medical needs, and unsanitary, unsafe living conditions.

Emotional or psychological abuse: The senior is extremely upset, agitated, withdrawn, unresponsive, fearful or depressed, or demonstrates some other unusual behavior.

Financial exploitation: Missing money or valuables. Unexplained withdrawals from bank accounts, or transfers between accounts. Unauthorized use of credit, debit or ATM card. Unpaid bills despite available funds. Checks written as a loan or gift. Abrupt changes in a will or other documents.

For more tips on how to recognize the warning signs of abuse during the pandemic, see the National Center on Elder Abuse website at NCEA.acl.gov/Resources/COVID-19.aspx.

What to Do

The best ways to help stop elder abuse is to be in touch and keep the lines of communication open. If you suspect any type of abuse or neglect in your relatives or friends home, report it to your local protective services agency.

Adult Protective Services is the government agency responsible for investigating elder abuse cases and providing help and guidance. Call the Eldercare Locator at 800-677-1116 to get the agency contact number in your area or visit NCEA.acl.gov/Resources/State.aspx.

The agency will ask what you observed, who was involved, and who they can contact to learn more. You dont need to prove that abuse is occurring; it is up to the professional.

Or, to report suspected abuse in a nursing home or assisted living facility, call the local Long-Term Care Ombudsman see LTCombudsman.org for contact information.

If, however, you feel the person is in immediate danger, call 911 or the local police for immediate help.

Send your senior questions to: Savvy Senior, P.O. Box 5443, Norman, OK 73070, or visit SavvySenior.org. Jim Miller is a contributor to the NBC Today show and author of The Savvy Senior book.

Read the original here:
How to recognize and stop elder abuse in the COVID Era - shorelinemedia.net

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