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Aug 2

hCG Diet NJ. The hCG Diet is a physician supervised …

by Ramtin Kassir, M.D., F.A.C.S.

The HCG Diet is a physician supervised weight loss program that can help shed 1 to 3 lbs per day by modifying their metabolism and eating habits for long term results.

HCG (Human Choriogonadotropin) is a hormone that is injected daily (or taken orally with under-the tongue drops), accompanied by a VLCD (very low calorie diet of approximately 500 calories).

Each course of treatment consists of a minimum 26 days, with 23 of those days requiring a daily dose of HCG, either through injections or under-the-tongue drops. Treatment can last as long as 43 days (with as many as 40 injections), unless a patient is able to lose 34 to 40 pounds before the allotted time has passed. Patients will not receive HCG injections for the last three days of treatment so the hormone can cycle completely out of their bodies before they resume a normal diet. (It also takes about three days for HCG's effects to "kick in.")

HCG is being called this because after taking it for weight loss, it reprograms your body to use stored fat for energy when your calorie intake is reduced for a period of time. In other words, it helps you to maintain your weight and not gain it back once normal caloric intake is resumed.

That will depend on your starting point. People with more weight to lose will experience a greater loss. On average, Dr. Kassirs patients lose around 15 to 40 lbs. per month.

Most men and women can use the HCG diet. It is recommended that you coordinate with Dr. Kassir concerning your weight loss, along with the appropriate implementation of the HCG protocol.

Some degree of moderation in eating will be necessary due to the tendency to gain weight after any type of weight loss program. However, stability of normal weight is relatively easy because the weight loss is from stored fat and not structural fat.

The HGC is taken in the form of sublingual drops. The drops are placed under the tongue twice a day (morning and afternoon). It can also be injected daily.

The hypothalamus gland moderates the thyroid, adrenals, fat storage and even more importantly, your metabolic rate.

The HCG is mobilizing your stored fat and making it available to your body as a source of energy. So even though you are consuming less calories, your body has access to the energy you have stored in fat cells. Therefore, you are utilizing thousands of calories that already exist in your body each day. Overall, most patients are not hungry and feel very good while on the program.

Yes. The HCG allows you to maintain the diet even while performing hard work or vigorous exercise. By mobilizing and using the abnormal fat stores for energy, you prevent the breakdown of lean muscle.

Absolutely! All women experience very high levels of HCG during the nine months of their pregnancy with no adverse affects. In comparison, the amount used for weight loss is miniscule and has very few, if any, side effects.

Human Chorionic Gonadotropin (HCG) is a natural hormone produce by our bodies. It has many functions and is used to treat many medical conditions. It is the hormone that almost completely controls metabolic functions.

It is not necessary. However those with balanced hormones are seeing greater results and have more success in maintaining that loss. Not to mention the overall health benefits and feeling of well being experience with balance hormones.

Yes!! Men usually get better results than women and it is just as safe for men as for women. HCG is actually already found in men. In fact, it is present in every human tissue, including males and non-pregnant females.

That will be determined by you and the doctor based upon how much weight you would like to lose. Those decisions are made during your consultation with Dr. Kassir.

HCG along with the Modified Simeon Diet causes your hypothalamus to mobilize fat from your abnormal fat cells to make it available for use. While you are only taking in ~500 calories, your hypothalamus is continually releasing the fat stored in your body. It maintains a normal basal metabolic rate and resets the hypothalamus to prevent future regain.

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hCG Diet NJ. The hCG Diet is a physician supervised ...


Aug 1

Viagra capsule – Viagra capsules price in india – Hayati Magazine (blog)


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Jul 31

HCG Diet | Rx HCG Diet Program | HCG Diet Info

What is HCG?

HCG stands for Human Chorionic Gonadotropin and is a glycoprotein composed of 244 amino acids.

The use of HCG for weight loss was pioneered by British endocrinologist A.T.W. Simeons while studying pregnant woman on an extremely low calorie diet in India in the 1950s. He thought it was a medical oxymoron that pregnant women in a 3rd world country just devastated by war, would walk everywhere, work and eat just a handful of calories produce normal weight and normal height babies. His medical logic determined that these babies should be malnourished. This led him to discover that when a woman is pregnant, her body produces HCG. Also while in India, Dr. Simeons treated fat boys with pituitary problems with low doses of HCG. He observed both lost fat rather than lean muscle tissue.

How does the HCG Diet work?

HCG mobilizes the adipose tissue (abnormal fat). There are 3 types of fat.

A pregnant womans body will produce over 1 million IU (International Units) of HCG to mobilize the abnormal fat full of vitamins, minerals and nutrients to nourish the unborn fetus. Dr. Simeons wrote, In pregnancy it would be most undesirable if the fetus were offered ample food only when there is a high influx from the intestinal tract. Ideal nutritional conditions for the fetus can only be achieved when the mothers blood is continually saturated with food, regardless of whether she eats or not, as otherwise a period of starvation might hamper the steady growth of the embryo.

The use of HCG in conjunction with VLCD (Very Low Calorie Diet) produces weight loss but more specifically, fat loss. The HCG Diet will reshape your body. Your body needs reserve and structural fat but does not need abnormal fat to survive. By using HCG, your body releases the unlocked calories and nutrients stored in your abnormal fat. Therefore, HCG used with VLCD will produce not only weight loss but fat loss.

Can men do the HCG Diet?

Dr. Simeons also wrote, When a male patient hears that he is about to be put into a condition which in some respects resembles pregnancy, he is usually shocked and horrified. The physician must therefore carefully explain that this does not mean that he will be feminized and that HCG in no way interferes with his sex. He must be made to understand that in the interest of the propagation of the species nature provides for a perfect functioning of the regulatory headquarters in the diencephalon during pregnancy and that we are merely using this natural safeguard as a means of correcting the diencephalic disorder which is responsible for his overweight.

Why cant I just do the low calorie diet without HCG?

Well, if just reducing calories is the solution to overweight and obesity then why hasnt worked in the past? Lets face it; if youre investigating the HCG Diet then Id say youve tried other diets in the past without the desired results. There are 2 basic reasons one should avoid just reducing calories to lose weight.

These 2 basic reasons are why you have not been successful by reducing calories in the past. A combination of HCG and VLCD can mobilize and reduce your abnormal fat.

Call us to get started on losing up to 1 pound of FAT per day.

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HCG Diet | Rx HCG Diet Program | HCG Diet Info


Jul 31

The New HCG Diet | The Dr. Oz Show

By now youve probably heard about it: the HCG Diet, an extreme diet that involves injections of HCG (human chorionic gonadotropin). HCG is the hormone women make when they are pregnant. Previously, the HCG Diet was defined by a 500-calorie diet paired with daily injections of HCG.

This diet is associated with dramatic weight loss, up to a pound a day. But the problem, up until now, was that no doctor could explain how it worked, and critics claimed the caloric restrictions are responsible for the weight loss and not the HCG hormone. Critics of the diet have also maintained that the weight lost cant be kept off. The HCG Diet has also had some odd rules. For example, it required the consumption of only one vegetable per meal, prohibited the use of oil, body lotions and hygiene products, and limited use of the HCG hormone to odd cycles of 23 and 46 days. The Diet also did not allow exercise. In addition, there had been no published guidelines on how to dose the HCG hormone; as a result, most providers of this diet are generally using random dosing of the prescription hormone. This was called the Simeons Protocol, and, in my opinion, it was wrong.

After years of research and treating thousands of patients, I am setting the record straight. The Simeons Protocol should no longer be in practice by any physician. My protocol is supported by numerous studies and clinical trials, the latest of which was presented to weight loss physicians at the October 2012 meeting of the American Society of Bariatric Physicians, and can be read at DrEmmasDiet.com. My dosing method is customized, with much higher doses than previously published, and Ive created specific guidelines for patients based on age and gender. I offer diets ranging from 500-1500 calories, and the diet should be chosen based on the patient and their history. I also encourage the proper types of exercise.

So, the most pressing question is: Do HCG injections work for weight loss? My answer is yes, absolutely. The trickier question is: How does HCG work for weight loss?

Here is my explanation, based on my research. Remember, HCG does not make you lose weight the diet makes you lose weight! However, the HCG injections change how you lose weight!

HCG injections keep you from losing muscle while you diet. By elevating hormone levels in the body, including testosterone, the HCG hormone creates an anabolic state (muscle-building) which counteracts the catabolic state (muscle-breakdown). There are hormone receptors on muscle fibers that respond to the increased hormone levels in patients taking the HCG hormone.

Why does that matter? During a fast, dramatic loss of pounds with crash dieting, there is a high amount of muscle that is lost. Because muscle is heavy, this loss looks good on the scale because the pounds are dropping quickly. When you lose muscle, its bad for your body, shape, and metabolism. The metabolism slows so much that dieter regain weight quickly, often regaining all the weight that was lost and then some. Additionally, it takes quite a bit of work to build back the muscle that has been lost.

My protocol, however, protects muscle from being lost. In fact, there is more of a pure fat loss, which causes a shrinking in inches and size of clothing. The great result is that one can become leaner, in a smaller clothing size, but with more muscle. This muscle allows for a stronger metabolism and helps people maintain their weight loss long after their diet is completed.

Read more about Dr. Emma's research study.

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The New HCG Diet | The Dr. Oz Show


Jul 31

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Jul 12

Man boobs (gynecomastia) could indicate serious health problems – TheHealthSite

A shapely pair of breasts is a thing of great beauty, except when its on a mans chest! Sometimes a sedentary lifestyle or underlying medical condition can cause mens pectoral areas to have the appearance of breasts. This unsightly appearance of pronounced chest flab can cause body-image and confidence issues in men. In medical terms, the condition is known as gynecomastia from the Greek terms gyneco- meaning woman and masto- which means breasts. But it is often known by its colloquial and often pejorative term man boobs or moobs for short.

(Read: How to get rid of man boobs or moobs)

What is gynecomastia?Gynecomastia is the benign enlargement of breast glandular tissue seen in men. Here is the bad news; the problem is quite prolific among men and studies say that at least 30 percent men will be afflicted by the bane of gynecomastia during their lifetime. There are two types of gynecomastia:

False or pseudogynecomastia- where subcutaneous fat (fat under the skin) causes the chest to have a breast-like appearance. True gynecomastia- where actual breast tissues develop in the pectoral region.

(Read: Yoga asanas to get rid of man boobs)

What causes gynecomastia?The primary causes of true gynecomastia are: The imbalance between the female hormone oestrogen and the male hormone androgen Increased production oestrogen than androgen Less production of androgen

What are the health hazards of having gynecomastia?Man boobs are basically benign conditions, which means by itself gynecomastia cannot cause any health hazards. Best case scenario will be staying away from tight-fitting t-shirts for a long time, and the worst? It can severely dent your self-esteem, cause anxiety problems and fear of malignant diseases.

But be warned! Man boobs can indicate a serious, underlying health condition, especially if you have true gynecomastia. If you suspect abnormal swelling in your pectoral region, seek medical help right away!

Following are some of the health conditions associated with true gynecomastia:

Cirrhosis or liver diseases: Hepatic cirrhosis or liver cirrhosis is often listed as a cause of gynecomastia. This is mainly because the liver is responsible for clearing excess hormones out of the system. When its functions are impaired, the liver fails to properly metabolise hormones such as oestrogen, leading to the formation of breasts in men. Moreover, spironolactone, a medicine used to treat cirrhosis can further exacerbate the condition.

Malnutrition: Prolonged periods of starvation can cause the development of gynecomastia. Malnourished men have lower levels of testosterone and gonadotropin in the body with normal levels of oestrogen produced in the adrenal glands. When the person returns to normal feeding, temporary breast enlargement is seen. This is mainly because some bodily systems increase their functions before the others. Heres an interesting trivia; World War 2 concentration camp inmates and Allied prisoners of war were known to have gynecomastia when they were freed since they were starved for long durations.

Problems in the hypothalamus, pituitary or testicles: The condition where the testicles dont produce enough testosterone is called male hypogonadism. It could probably result from a problem in the testicles or from the hypothalamus or pituitary gland. The hypothalamus produces a hormone that signals the pituitary to produce luteinising hormones that trigger testosterone production. The skewed testosterone to oestrogen ratio then causes the growth of male breasts.

Kidney failure and dialysis: Impaired renal functions simply cause hormonal abnormalities, especially decreased testosterone production and increased oestrogen levels. The problem can be reversed by kidney transplantation, but dialysis cannot do much to help the patient. Certain drugs like cyclosporin taken after kidney transplant can cause development of breasts in men.

And as far as dialysis is concerned, gynecomastia is seen in 50 percent of patients who undergo the procedure. Before dialysis, the patients have restricted diets causing them to go on a starvation mode for a while. Gynecomastia is triggered when they return to a regular diet.

Ectopic hcg production: Healthy men have normal levels of Human chorionic gonadotropin or hCG. But if by any chance, there is large-cell carcinoma, gastric carcinoma or renal cell carcinoma, the ectopic production of hCG can trigger gynecomastia.

True hermaphroditism: The condition where a person is born with both ovarian and testicular tissue is called as true hermaphroditism. The ovarian tissues of the person produce more oestrogen and inhibit the production of testosterone, leading to gynecomastia or male breast formation.

Increased cortisol levels: If there is an excess of the cortisol in the system due to mental stress, the body starts secreting excessive oestrogen precursors. Increased serum cortisol and oestrogen coupled with low serum testosterone is a sure shot formula for gynecomastia!

Type 1 diabetes: Diabetic mastopathy is a benign condition seen in men suffering from type 1 diabetes. Men who have been battling the condition for a long time eventually develop tough masses or lesions on their chest.Spinal and bulbar muscular atrophy or Kennedys disease: It is a degenerative neural disorder caused due to the weakness of motor neurons in the brainstem and the spinal cord. The disease also affects the endocrine glands, causing gynecomastia.

Spinal and bulbar muscular atrophy or Kennedys disease: It is a degenerative neural disorder caused due to the weakness of motor neurons in the brainstem and the spinal cord. The disease also affects the endocrine glands, causing gynecomastia.

References:

Cuhaci, N., Polat, S. B., Evranos, B., Ersoy, R., & Cakir, B. (2014). Gynecomastia: clinical evaluation and management. Indian journal of endocrinology and metabolism, 18(2), 150.

Image source: Shutterstock

Published: July 12, 2017 5:51 pm | Updated:July 12, 2017 6:02 pm

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Man boobs (gynecomastia) could indicate serious health problems - TheHealthSite


Jul 12

Human chorionic gonadotropin – Wikipedia

Human chorionic gonadotropin (hCG) is a hormone produced by the placenta after implantation.[1][2] The presence of hCG is detected in some pregnancy tests (HCG pregnancy strip tests). Some cancerous tumors produce this hormone; therefore, elevated levels measured when the patient is not pregnant can lead to a cancer diagnosis and, if high enough, paraneoplastic syndromes. However, it is not known whether this production is a contributing cause or an effect of carcinogenesis. The pituitary analog of hCG, known as luteinizing hormone (LH), is produced in the pituitary gland of males and females of all ages.[1][3]

Regarding endogenous forms of hCG, there are various ways to categorize and measure them, including total hCG, C-terminal peptide total hCG, intact hCG, free -subunit hCG, -core fragment hCG, hyperglycosylated hCG, nicked hCG, alpha hCG, and pituitary hCG. Regarding pharmaceutical preparations of hCG from animal or synthetic sources, there are many gonadotropin preparations, some of which are medically justified and others of which are of a quack nature. As of December 6, 2011[update], the United States Food and Drug Administration has prohibited the sale of "homeopathic" and over-the-counter hCG diet products and declared them fraudulent and illegal.[4][5][6]

Human chorionic gonadotropin is a glycoprotein composed of 237 amino acids with a molecular mass of 25.7 kDa.[7]

It is heterodimeric, with an (alpha) subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and (beta) subunit that is unique to hCG.

The two subunits create a small hydrophobic core surrounded by a high surface area-to-volume ratio: 2.8 times that of a sphere. The vast majority of the outer amino acids are hydrophilic.[7]

Human chorionic gonadotropin interacts with the LHCG receptor of the ovary and promotes the maintenance of the corpus luteum during the beginning of pregnancy. This allows the corpus luteum to secrete the hormone progesterone during the first trimester. Progesterone enriches the uterus with a thick lining of blood vessels and capillaries so that it can sustain the growing fetus[citation needed].

Due to its highly negative charge, hCG may repel the immune cells of the mother, protecting the fetus during the first trimester[citation needed]. It has also been hypothesized that hCG may be a placental link for the development of local maternal immunotolerance[citation needed]. For example, hCG-treated endometrial cells induce an increase in T cell apoptosis (dissolution of T cells). These results suggest that hCG may be a link in the development of peritrophoblastic immune tolerance, and may facilitate the trophoblast invasion, which is known to expedite fetal development in the endometrium.[10] It has also been suggested that hCG levels are linked to the severity of morning sickness or Hyperemesis gravidarum in pregnant women.[11]

Because of its similarity to LH, hCG can also be used clinically to induce ovulation in the ovaries as well as testosterone production in the testes. As the most abundant biological source is women who are presently pregnant, some organizations collect urine from pregnant women to extract hCG for use in fertility treatment.[12][13]

Human chorionic gonadotropin also plays a role in cellular differentiation/proliferation and may activate apoptosis.[14]

Naturally, it is produced in the human placenta by the syncytiotrophoblast.

Like other gonadotropins, it can be extracted from the urine of pregnant women or produced from cultures of genetically modified cells using recombinant DNA technology.

In Pregnyl, Follutein, Profasi, Choragon and Novarel, it is extracted from the urine of pregnant women. In Ovidrel, it is produced with recombinant DNA technology.[15]

Regarding endogenous forms of hCG, there are various ways to categorize and measure them, including total hCG, C-terminal peptide total hCG, intact hCG, free -subunit hCG, -core fragment hCG, hyperglycosylated hCG, nicked hCG, alpha hCG, and pituitary hCG.

Regarding pharmaceutical preparations of hCG from animal or synthetic sources, there are many gonadotropin preparations, some of which are medically justified and others of which are of a quack nature.

Blood or urine tests measure hCG. These can be pregnancy tests. hCG-positive indicates an implanted blastocyst and mammalian embryogenesis. These can be done to diagnose and monitor germ cell tumors and gestational trophoblastic diseases.

Concentrations are commonly reported in thousandth international units per milliliter (mIU/ml). The international unit of hCG was originally established in 1938 and has been redefined in 1964 and in 1980.[16] At the present time, 1 international unit is equal to approximately 2.351012 moles,[17] or about 6108 grams.[18]

Most tests employ a monoclonal antibody, which is specific to the -subunit of hCG (-hCG). This procedure is employed to ensure that tests do not make false positives by confusing hCG with LH and FSH. (The latter two are always present at varying levels in the body, whereas the presence of hCG almost always indicates pregnancy.)

Many hCG immunoassays are based on the sandwich principle, which uses antibodies to hCG labeled with an enzyme or a conventional or luminescent dye. Pregnancy urine dipstick tests are based on the lateral flow technique.

The following is a list of serum hCG levels. (LMP is the last menstrual period dated from the first day of the last menstrual period.) The levels grow exponentially after conception and implantation.

The ability to quantitate the hCG level is useful in the monitoring germ cell and trophoblastic tumors, follow-up care after miscarriage, and in diagnosis of and follow-up care after treatment of ectopic pregnancy. The lack of a visible fetus on vaginal ultrasound after the hCG levels have reached 1500 mIU/ml is strongly indicative of an ectopic pregnancy.[21] Still, even an hCG over 2000 IU/l does not necessarily exclude the presence of a viable intrauterine pregnancy in such cases.[22]

As pregnancy tests, quantitative blood tests and the most sensitive urine tests usually detect hCG between 6 and 12 days after ovulation.[23] However, it must be taken into account that total hCG levels may vary in a very wide range within the first 4 weeks of gestation, leading to false results during this period.[24] A rise of 35% over 48 hours is proposed as the minimal rise consistent with a viable intrauterine pregnancy.[22]

Gestational trophoblastic disease like hydatidiform moles ("molar pregnancy") or choriocarcinoma may produce high levels of hCG (due to the presence of syncytialtrophoblasts- part of the villi that make up the placenta) despite the absence of an embryo. This, as well as several other conditions, can lead to elevated hCG readings in the absence of pregnancy.

hCG levels are also a component of the triple test, a screening test for certain fetal chromosomal abnormalities/birth defects.

A study of 32 normal pregnancies came to the result a gestational sac of 13mm was detected at a mean hCG level of 1150 IU/l (range 800-1500), a yolk sac was detected at a mean level of 6000 IU/l (range 4500-7500) and fetal heartbeat was visible at a mean hCG level of 10,000 IU/l (range 8650-12,200).[25]

Human chorionic gonadotropin can be used as a tumor marker,[26] as its subunit is secreted by some cancers including seminoma, choriocarcinoma, germ cell tumors, hydatidiform mole, teratoma with elements of choriocarcinoma, and islet cell tumor. For this reason, a positive result in males can be a test for testicular cancer. The normal range for men is between 0-5 mIU/mL. Combined with alpha-fetoprotein, -HCG is an excellent tumor marker for the monitoring of germ cell tumors.[citation needed]

Human chorionic gonadotropin injection is extensively used for final maturation induction in lieu of luteinizing hormone. In the presence of one or more mature ovarian follicles, ovulation can be triggered by the administration of HCG. As ovulation will happen between 38 and 40 hours after a single HCG injection,[27] procedures can be scheduled to take advantage of this time sequence,[28] such as intrauterine insemination or sexual intercourse. Also, patients that undergo IVF, in general, receive HCG to trigger the ovulation process, but have an oocyte retrieval performed at about 34 to 36 hours after injection by, a few hours before the eggs actually would be released from the ovary.

As HCG supports the corpus luteum, administration of HCG is used in certain circumstances to enhance the production of progesterone.

In the male, HCG injections are used to stimulate the Leydig cells to synthesize testosterone. The intratesticular testosterone is necessary for spermatogenesis from the sertoli cells. Typical uses for HCG in men include hypogonadism and fertility treatment.

Several vaccines against human chorionic gonadotropin (hCG) for the prevention of pregnancy are currently in clinical trials.[29]

In the case of female patients who want to be treated with HCG Pregnyl:[30] a) Since infertile female patients who undergo medically assisted reproduction (especially those who need in vitro fertilization), are known to often be suffering from tubal abnormalities, after a treatment with this drug they might experience many more ectopic pregnancies. This is why early ultrasound confirmation at the beginning of a pregnancy (to see whether the pregnancy is intrauterine or not) is crucial. - Pregnancies that have occurred after a treatment with this medicine are submitted to a higher risk of multiplets. - Female patients who have thrombosis, severe obesity or thrombophilia should not be prescribed this medicine as they have a higher risk of arterial or venous thromboembolic events after or during a treatment with HCG Pregnyl. b)Female patients who have been treated with this medicine are usually more prone to pregnancy losses.

In the case of male patients: A prolonged treatment with HCG Pregnyl is known to regularly lead to increased production of androgen. Therefore: Patients who are suffering from overt or latent cardiac failure, hypertension, renal dysfunction, migraines or epilepsy might not be allowed to start using this medicine or may require a lower dose of HCG Pregnyl. Also this medicine should be used with extreme caution in the treatment of prepubescent teenagers in order to reduce the risk of precocious sexual development or premature epiphyseal closure. This type of patients' skeletal maturation should be closely and regularly monitored.

Both male and female patients who have the following medical conditions must not start a treatment with HCG Pregnyl: (1) Hypersensitivity to this medicine or to any of its main ingredients. (2) Known or possible androgen-dependent tumors for example male breast carcinoma or prostatic carcinoma.

In the world of performance-enhancing drugs, HCG is increasingly used in combination with various anabolic androgenic steroid (AAS) cycles. As a result, HCG is included in some sports' illegal drug lists.

When exogenous AAS are put into the male body, natural negative-feedback loops cause the body to shut down its own production of testosterone via shutdown of the hypothalamic-pituitary-gonadal axis (HPGA). This causes testicular atrophy, among other things. HCG is commonly used during and after steroid cycles to maintain and restore testicular size as well as normal testosterone production.[31]

High levels of AASs, that mimic the body's natural testosterone, trigger the hypothalamus to shut down its production of gonadotropin-releasing hormone (GnRH) from the hypothalamus. Without GnRH, the pituitary gland stops releasing luteinizing hormone (LH). LH normally travels from the pituitary via the blood stream to the testes, where it triggers the production and release of testosterone. Without LH, the testes shut down their production of testosterone.[32] In males, HCG helps restore and maintain testosterone production in the testes by mimicking LH and triggering the production and release of testosterone.

If HCG is used for too long and in too high a dose, the resulting rise in natural testosterone would eventually inhibit its own production via negative feedback on the hypothalamus and pituitary gland.[citation needed]

Professional athletes who have tested positive for HCG have been temporarily banned from their sport, including a 50-game ban from MLB for Manny Ramirez in 2009[33] and a 4-game ban from the NFL for Brian Cushing for a positive urine test for HCG.Mixed Martial Arts fighter Dennis Siver was fined $19,800 and suspended 9 months for being tested positive after his bout at UFC 168.[35]

British endocrinologist Albert T. W. Simeons proposed HCG as an adjunct to an ultra-low-calorie weight-loss diet (fewer than 500 calories).[36] Simeons, while studying pregnant women in India on a calorie-deficient diet, and "fat boys" with pituitary problems (Frlich's syndrome) treated with low-dose HCG, observed that both lost fat rather than lean (muscle) tissue.[36] He reasoned that HCG must be programming the hypothalamus to do this in the former cases in order to protect the developing fetus by promoting mobilization and consumption of abnormal, excessive adipose deposits. Simeons in 1954 published a book entitled Pounds and Inches, designed to combat obesity. Simeons, practicing at Salvator Mundi International Hospital in Rome, Italy, recommended low-dose daily HCG injections (125IU) in combination with a customized ultra-low-calorie (500 cal/day, high-protein, low-carbohydrate/fat) diet, which was supposed to result in a loss of adipose tissue without loss of lean tissue.[36]

Simeons' results were not reproduced by other researchers and in 1976 in response to complaints the FDA required Simeons and others to include the following disclaimer on all advertisements:[37]

These weight reduction treatments include the injection of HCG, a drug which has not been approved by the Food and Drug Administration as safe and effective in the treatment of obesity or weight control. There is no substantial evidence that HCG increases weight loss beyond that resulting from caloric restriction, that it causes a more attractive or "normal" distribution of fat, or that it decreases the hunger and discomfort associated with calorie-restrictive diets.

1976 FDA-mandated disclaimer for HCG diet advertisements

There was a resurgence of interest in the "HCG diet" following promotion by Kevin Trudeau who was later banned from making HCG diet weight-loss claims by the U.S. Federal Trade Commission and eventually jailed over such claims.[38]

While not specifically cited here, review studies refuting the HCG diet have been published in the Journal of the American Medical Association and the American Journal of Clinical Nutrition,[39] concluded that HCG is not more effective as a weight-loss aid than dietary restriction alone.[40]

A meta analysis found that studies supporting HCG for weight loss were of poor methodological quality and concluded that "there is no scientific evidence that HCG is effective in the treatment of obesity; it does not bring about weight-loss or fat-redistribution, nor does it reduce hunger or induce a feeling of well-being".[41]

Further, on November 15, 2016, the American Medical Association (AMA) passed policy that "The use of human chorionic gonadotropin (HCG) for weight loss is inappropriate."[42]

There is no scientific evidence that HCG is effective in the treatment of obesity. The meta-analysis found insufficient evidence supporting the claims that HCG is effective in altering fat-distribution, hunger reduction or in inducing a feeling of well-being. The authors stated the use of HCG should be regarded as an inappropriate therapy for weight reduction In the authors opinion, Pharmacists and physicians should be alert on the use of HCG for Simeons therapy. The results of this meta-analysis support a firm standpoint against this improper indication. Restraints on physicians practicing this therapy can be based on our findings.

According to the American Society of Bariatric Physicians, no new clinical trials have been published since the definitive 1995 meta-analysis.[43]

The scientific consensus is that any weight loss reported by individuals on an "HCG diet" may be attributed entirely to the fact that such diets prescribe calorie intake of between 500 and 1,000 calories per day, substantially below recommended levels for an adult, to the point that this may risk health effects associated with malnutrition.[44]

Controversy about, and shortages[45] of, injected HCG for weight loss have led to substantial Internet promotion of "homeopathic HCG" for weight control. The ingredients in these products are often obscure, but if prepared from true HCG via homeopathic dilution, they contain either no HCG at all or only trace amounts. Moreover, it is highly unlikely that oral HCG is bioavailable due to the fact that digestive protease enzymes and hepatic metabolism renders peptide-based molecules (such as insulin and human growth hormone) biologically inert. HCG can likely only enter the bloodstream through injection.

The United States Food and Drug Administration has stated that over-the-counter products containing HCG are fraudulent and ineffective for weight loss. They are also not protected as homeopathic drugs and have been deemed illegal substances.[46][47] HCG itself is classified as a prescription drug in the United States and it has not been approved for over-the-counter sales by the FDA as a weight loss product or for any other purposes, and therefore neither HCG in its pure form nor any preparations containing HCG may be sold legally in the country except by prescription.[4] In December 2011, FDA and FTC started to take actions to pull unapproved HCG products from the market.[4] In the aftermath, some suppliers started to switch to "hormone-free" versions of their weight loss products, where the hormone is replaced with an unproven mixture of free amino acids[48] or where radionics is used to transfer the "energy" to the final product.

In order to induce a stronger immune response, some versions of human chorionic gonadotropin-based anti-fertility vaccines were designed as conjugates of the subunit of HCG covalently linked to tetanus toxoid.[29][49] It has been alleged that a non-conjugated tetanus vaccine used in developing countries is laced with a human chorionic gonadotropin based anti-fertility drug[50] and is distributed as a means of mass sterilization.[51] This charge has been vigorously denied by the World Health Organization (WHO) and UNICEF.[52] Others have argued that a hCG laced vaccine could not be used for sterilization since the effects of the anti-fertility vaccines are reversible (requiring booster doses to maintain immunity) and a non-conjugated vaccine is likely to be ineffective.[53][54] Finally, independent testing of the tetanus vaccine by Kenyas health authorities has revealed no traces of the human chorionic gonadotropin hormone.[55]

PDB gallery

1hcn: STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN AT 2.6 ANGSTROMS RESOLUTION FROM MAD ANALYSIS OF THE SELENOMETHIONYL PROTEIN

1hrp: CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN

1qfw: TERNARY COMPLEX OF HUMAN CHORIONIC GONADOTROPIN WITH FV ANTI ALPHA SUBUNIT AND FV ANTI BETA SUBUNIT

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Human chorionic gonadotropin - Wikipedia


Jul 5

HCG diet: Is it safe and effective? – Mayo Clinic

No on both counts. In fact, the Food and Drug Administration has advised consumers to steer clear of over-the-counter weight-loss products that contain HCG. HCG is human chorionic gonadotropin, a hormone produced during pregnancy.

As a prescription medication, HCG is used mainly to treat fertility issues. HCG is not approved for over-the-counter use, nor has it been proved to work for weight loss. Companies that sell over-the-counter HCG weight-loss products are breaking the law.

So why has there been so much talk about the HCG diet? Perhaps it's because the diet recommends severe calorie restriction typically just 500 to 800 calories a day. People who follow such a very low calorie diet are likely to lose weight, at least in the short term.

However, diets that so severely limit calories have risks, such as gallstone formation, irregular heartbeat and an imbalance of electrolytes.

Side effects have also been reported with the HCG diet and include fatigue, irritability, restlessness, depression, fluid buildup (edema), and swelling of the breasts in boys and men (gynecomastia). Another serious concern is the risk of blood clots forming and blocking blood vessels (thromboembolism).

If weight loss is your goal, there are safer ways to lose weight. Talk with your doctor or other health care provider about how to make healthy changes that lead to permanent weight loss, such as eating a balanced diet and getting regular exercise.

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HCG diet: Is it safe and effective? - Mayo Clinic



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