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Public release date: 24-May-2012 [ | E-mail | Share ]

Contact: Dawn Peters healthnews@wiley.com 781-388-8408 Wiley-Blackwell

New research found that moderate exercise does not improve lipoprotein concentrations in obese patients with non alcoholic fatty liver disease (NAFLD). Results published in the June issue of Hepatology, a journal of the American Association for the Study of Liver Diseases, report that moderate physical activity produces only a small decrease in triglyceride and alanine transaminase (ALT) levels.

Obesity is a rampant health concern worldwide. In fact, the World Health Organization (WHO) reported in 2008 that 1.5 billion people, age 20 and older, were overweight, and of these, 200 million men and roughly 300 million women were considered obese. One common complication of obesity is NAFLD, which causes metabolic abnormalities that can lead to severe liver disease. Previous research found that weight loss and regular exercise improved metabolic disturbances associated with NALFD.

Evidence of the effects of regular physical activity on NAFLD, independent of weight loss, is limited. To further investigate, Dr. Samuel Klein and colleagues from the Washington University School of Medicine in St. Louis, Mo. evaluated the impact of physical activity programs recommended by the Department of Health and Human Services on ALT, cholesterol and triglyceride levels in obese NAFLD patients.

This single-center trial included 18 obese participants with NAFLD who were randomized to 16 weeks of 30 to 60 minutes of moderate exercise at 5 days per week with 12 participating in physical activity and 6 in the control group. Researchers analyzed the impact of exercise on intrahepatic triglyceride (IHTG), very low density lipoproteins (VLDL), and apolipoprotein B-100 (apoB-100).

Analysis shows that exercise decreased IHTG content by 10%, but did not change total body weight or body fat percentage. Total body weight prior to exercise program was 103.1 kg and 102.9 kg after physical activity; body fat was 38.9 before and 39.2 after exercise training. The authors found no change in liver lipoprotein levels (VLDL or apoB-100) in obese NAFLD patients who engaged in physical activity training.

"Our data demonstrate that a moderate intensity exercise program followed by obese patients with NALFD causes a small decrease in IHTG content, even when body weight and total body fat mass are maintained," concludes Dr. Klein. "Current exercise recommendations seem to have only a modest effect on triglycerides and ALT levels, suggesting that improvement in lipoprotein metabolism and fatty liver (steatosis) may be due to weight loss and not increased physical activity." The authors suggest further study of the impact of moderate exercise on IHTG content in those with NAFLD.

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This study is published in Hepatology. Media wishing to receive a PDF of the article may contact healthnews@wiley.com.

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Exercise does not improve lipoprotein levels in obese patients with fatty liver disease

SAN DIEGO, May 21, 2012 /PRNewswire/ -- Arena Pharmaceuticals, Inc. (ARNA) today announced the completion of an underwritten public offering of 12,650,000 shares of its common stock, including 1,650,000 shares sold pursuant to the full exercise of an over-allotment option previously granted to the underwriters. All of the shares were offered by Arena at a price to the public of $5.50 per share. The gross proceeds to Arena from this offering were approximately $69.6 million, before deducting the underwriting discounts and commissions and other estimated offering expenses payable by Arena. Arena anticipates using the net proceeds from the offering for general corporate purposes, which may include expenses related to the commercialization of lorcaserin, if approved, as well as for research and development expenses, capital expenditures, working capital, and general and administrative expenses.

Jefferies & Company, Inc. and Piper Jaffray & Co. acted as joint book-running managers for the offering. BMO Capital Markets acted as a co-manager for the offering.

A registration statement relating to the shares described above was previously filed with and has become effective by rule of the Securities and Exchange Commission (SEC). A final prospectus supplement related to the offering has been filed with the SEC and is available on the SEC's website located at http://www.sec.gov. Copies of the final prospectus supplement and the accompanying prospectus relating to this offering may be obtained from Jefferies & Company, Inc., Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, 12th floor, New York, NY 10022 or by telephone at 877-547-6340 or by email at Prospectus_Department@Jefferies.com, or Piper Jaffray & Co., Attention: Prospectus Department, 800 Nicollet Mall, J12S03, Minneapolis, MN 55402 or by telephone at 800-747-3924 or by email at prospectus@pjc.com.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

About Arena Pharmaceuticals

Arena is a clinical-stage biopharmaceutical company focused on discovering, developing and commercializing oral drugs that target G protein-coupled receptors, an important class of validated drug targets, in four major therapeutic areas: cardiovascular, central nervous system, inflammatory and metabolic diseases.

Arena Pharmaceuticals and Arena are registered service marks of the company.

Forward-Looking Statements

Certain statements in this press release are forward-looking statements that involve a number of risks and uncertainties. Such forward-looking statements include statements about Arena's anticipated use of proceeds from the offering, its focus, its research and development programs, and its ability to discover and develop compounds and commercialize drugs. For such statements, Arena claims the protection of the Private Securities Litigation Reform Act of 1995. Actual events or results may differ materially from Arena's expectations. Factors that could cause actual results to differ materially from the forward-looking statements include, but are not limited to, the following: the timing of regulatory review is uncertain and Arena's applications for regulatory approval of lorcaserin may not be reviewed when or as anticipated; the timing, results, influence and other impact of FDA advisory committee meetings relating to lorcaserin and other drug candidates; the FDA may not complete its review of the lorcaserin NDA resubmission by the PDUFA date; nonclinical and clinical data is voluminous and detailed, and regulatory agencies may interpret or weigh the importance of data differently and reach different conclusions than Arena or others, request additional information, have additional recommendations or change their guidance or requirements before or after approval; data and other information related to lorcaserin and Arena's other research and development programs may not meet safety, efficacy or other regulatory requirements or otherwise be sufficient for regulatory review or approval; even if any of Arena's drug candidates is approved for marketing, such approval may be subject to limitations on the indicated uses, restricted distribution methods and other limitations; risks related to commercializing new products; unexpected or unfavorable new data; Arena's ability to obtain and defend its patents; the timing, success and cost of Arena's research and development programs; results of clinical trials and other studies are subject to different interpretations and may not be predictive of future results; clinical trials and other studies may not proceed at the time or in the manner expected or at all; having adequate funds; risks related to relying on collaborative agreements; the timing and receipt of payments and fees, if any, from collaborators; and satisfactory resolution of litigation or other disagreements with others. Additional factors that could cause actual results to differ materially from those stated or implied by Arena's forward-looking statements are disclosed in Arena's filings with the SEC, including its Quarterly Report on Form 10-Q for the quarter ended March 31, 2012 and its Current Report on Form 8-K filed with the SEC on May 15, 2012. These forward-looking statements represent Arena's judgment as of the time of this release. Arena disclaims any intent or obligation to update these forward-looking statements, other than as may be required under applicable law.

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Arena Pharmaceuticals Announces Exercise in Full of Over-Allotment Option and Completion of Public Offering of Common ...

KEY POINTS

* Researchers found that the people with asthma who exercised were no more likely to experience asthma-related problems than those who didnt. * Exercise might help alleviate asthma symptoms over time by increasing cardiovascular fitness.

By Christen Brownlee, Contributing Writer Research Source: The Cochrane Library Health Behavior News Service

Newswise Not only is it safe for people with asthma to exercise, but doing so could reduce their risk of asthma symptoms or attacks, according to a new evidence review in The Cochrane Library.

Many people with asthma report avoiding exercise because theyre afraid it could trigger symptoms including shortness of breath, wheezing or a full-blown asthma attack, said review author Kristin V. Carson. These fears might be encouraged from misreading their symptoms, their familys beliefs about exercise and asthma, or even from their physicians.

Over time, Carson explains, patients can become out of shape, losing muscle mass and cardiovascular fitness. That makes any future attempts at physical activity significantly harder, increasing the chances that patients will become fatigued and breathless and further discouraging physical activity.

This results in a spiraling cycle, she says, in which patients are even more likely to avoid exercise.

To determine whether exercise was a danger to asthmatics, Carson and her colleagues reviewed previous studies that looked at the effects of physical training on people with asthma , comparing patients who received no or minimal physical activity to those who exercised for at least 20 minutes, twice a week, over the course of four weeks.

The researchers found that the patients who had exercisedusing physical training as varied as running outdoors or on a treadmill, cycling, swimming or circuit trainingwere no more likely to have a serious asthma-related problem than those who werent exercising or who did light exercising such as yoga. Additionally, Carson said, their findings showed that patients in exercise programs improved their cardiovascular fitness, which in turn could reduce asthma symptoms over time. Some limited evidence from the included studies also suggested that exercise improved patients quality of life, she added, which could contribute to other health benefits and improved psychological well-being.

We found no reason for people with stable asthma to refrain from regular exercise, Carson said. Physicians should encourage their patents with stable asthma to engage in physical training programs.

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People with Asthma Get the Green Light for Exercise

For more than a decade, students at elementary schools in the Rockwood School District had 30-minute physical education classes, five days a week.

The classes at Babler and Chesterfield elementary schools were so innovative and vigorous that in 2009 the National Association for Sport and Physical Education recognized them with STARS Awards. Only 30 other schools nationwide have received the recognition.

Then the Rockwood School Board cut physical education to four days a week last year, so students could take a music class on the fifth day.

"They said we are way over the federal minimum (for recommended physical education hours) so we have room to play with," said Eddie Mattison, facilitator of physical education for Rockwood.

Such cuts illustrate the balancing act these days between academics and PE, as schools struggle to raise test scores in the face of a growing obesity epidemic.

More than one-third of children and more than two-thirds of adults are overweight or obese. The number of adolescents with type 2 diabetes increased ten-fold between 1982 and 1994. And the U.S. Centers for Disease Control and Prevention estimates that one in three children born in 2000 will have the disease at some point, unless they start moving more and eating less.

Nationwide, schools have taken big strides in removing vending machines, or restocking them with healthier choices, and revamping lunches. Yet efforts to buff up physical activity during the school day haven't been as rigorous in most states, particularly when it comes to allocating time for it.

"The length of the school day is the same as it was 100 years ago when kids went home to work in the fields," said Paula Kun, communications director for the National Association for Sport and Physical Education. "But a lot of things have changed since then, yet no one wants to change the way things are done at school. They say it costs too much money."

Federal guidelines recommend that children get 60 minutes of exercise a day. They also suggest a minimum of 150 minutes of physical education a week in elementary schools and 220 minutes in middle and high schools. Recess should be additional. But most states don't require anywhere near that.

In Missouri:

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Schools get creative with PE while reducing hours

Portland, Oregon (PRWEB) May 17, 2012

In support of the companys focus on achieving fit and healthy lifestyles, American Fitness employees will demonstrate the importance of cardio exercise by participating in the American Heart Associations 2012 Heart and Stroke Walk in Oregon and SW Washington. This fundraising walk is one of more than 300 being led by the American Heart Association (AHA) in cities across the United States in an effort to fight heart disease and save lives. Proceeds from the walk support research, education, and advocacy programs.

Cardiovascular disease is currently the number one killer of all Americans. Risk factors include obesity, poor nutrition, physical inactivity, smoking, high blood pressure and/or cholesterol, and diabetes many of which are on the rise in the United States. Especially alarming are recent statistics showing that nearly 1 in 3 children and teens in the US is now overweight or obese, putting them at risk for becoming unhealthy adults. American Fitness recognizes the importance of raising awareness of these serious health issues, and supports employees both in advocating for better health, as well as improving their own personal health and fitness through good nutrition and exercise.

For companies looking to improve the health and wellness of their employees, the first step is empowering them to get active. The AHA recommends 30 minutes of moderate exercise a day, at least 5 days a week. This should include regular cardiovascular exercise that works the heart and lungs. Good examples are walking, jogging, swimming, or working out on treadmills, exercise bikes, or other cardio exercise equipment. Getting involved in a group fitness event, such as the Heart Walk, is great way to bring employees together to support each other in making lifestyle changes.

We are proud to support our employees in participating in the AHA Heart Walk, said Ron Thompson, President of AmericanFitness.net. It is vitally important that Americans start to adopt healthier lifestyles to reduce the risk of heart disease and stroke, as well as related diseases.

Regular exercise is a key component of establishing healthy hearts and healthy employees. American Fitness is experienced in helping companies establish on-site fitness centers to encourage employees to exercise more. More information on strength and cardio exercise equipment for group facilities is available at AmericanFitness.net.

About American Fitness American Fitness is a leading retailer of home and commercial fitness equipment. Headquartered in Portland, Oregon, AmericanFitness.net is the chosen provider of exercise equipment for schools, hotels, public service agencies, and US military organizations across the United States and abroad. American Fitness specializes in custom gym and fitness center design using top brand cardio and weight training equipment. With a focus on service and customer satisfaction, American Fitness seeks to support individuals and organizations in achieving fit and healthy lifestyles.

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American Fitness to Highlight Importance of Cardio Exercise Through Participation in Heart Walk

WHITE SANDS, N.M., May 14, 2012 /PRNewswire/ -- In the largest deployment yet of the General Dynamics-developed JTRS HMS Manpack and Rifleman Radios and the Warfighter Information Network-Tactical (WIN-T) network, the U.S. Army is now conducting realistic operational evaluations of the next generation of high-speed communications equipment developed for ground forces. WIN-T Increment 2 and the JTRS Manpack and Rifleman radios form the baseline for the Army's on-the-move tactical network. These two networking programs of record are completing operational testing at the Network Integration Exercise (NIE) 12.2 at White Sands Missile Range, N.M., through the end of May.

The JTRS HMS Manpack radio (AN/PRC-155) provides line-of-sight and beyond-line-of-sight, high-bandwidth waveforms for on-the-move voice, sensor, data and position-location capabilities on soldiers or in vehicles. The PRC-155 two-channel networking manpack radio is the first tactical radio capable of supporting all three non-proprietary JTRS networking waveforms and is engineered to easily port additional JTRS waveforms as they complete development. Nearly five pounds-per-channel lighter and with twice the communications and networking capabilities of some single-channel manpack radios, the PRC-155 is also interoperable with radios that U.S. forces are currently using, including interim radios that cannot meet the networking requirements of the future force.

The PRC-155 Manpack radio has been a part of all three NIE exercises and is the only Soldier Radio Waveform (SRW) radio undergoing Multi-service Operational Test and Evaluation at NIE 12.2.

In addition, over 700 JTRS HMS networking radios are deployed at NIE 12.2. More than 20 percent smaller than current tactical handhelds, and with battery life of over ten hours, the PRC-154 Rifleman Radio is the government-issued networking radio of choice for dismounted soldiers, and the only SRW-capable radio proven in combat. When size, weight and power limits constrain vehicle integration options in vehicles needing networked communications, the Rifleman Radio also mounts to a 'Sidewinder' accessory that provides power amplification and is compatible with standard military mounting trays and vehicle intercom systems. The Sidewinder accessory/Rifleman Radio combination, which premiered at the previous NIE 12.1 as a system under evaluation, is also part of the NIE 12.2.

"The HMS Manpack and Rifleman Radios are the only tactical radios that have been 'systems under test' at the NIE 12.2 events. This means that detailed performance data, such as message completion rate, has been gathered and analyzed by independent observers while soldiers stress the system. This rigorous testing often reveals operational issues that are not evident in field or laboratory evaluations, which can then be addressed before products are deployed to the field," said Chris Marzilli, president of General Dynamics C4 Systems. "HMS program radios are the only radios that have already been evaluated and had their test findings addressed."

The HMS program mission is to develop and produce affordable networking tactical radio systems that meet the requirements of the Army, Navy, Air Force, Marine Corps and Special Operations Forces communities. A success story for the Army's Agile Acquisition process, both the PRC-155 and PRC-154 radios are planned for deployment with the first integrated group of network technologies that will be fielded to Army Brigade Combat Teams, starting in the fall of 2012.

General Dynamics is also the prime contractor for the Army's number one modernization priority, the Warfighter Information Network-Tactical (WIN-T). Undergoing initial operational testing at NIE 12.2, WIN-T Increment 2 extends the network for Brigade Combat Teams down to company level and provides on-the-move capabilities to commanders and staff at division through company levels.

For more information about JTRS HMS radios by General Dynamics C4 Systems, please visit http://www.gdradios.com.

General Dynamics C4 Systems is a business unit of General Dynamics (GD). Information about General Dynamics is available online at http://www.generaldynamics.com.

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General Dynamics Delivers Powerful Tactical Network and Radios for Army's NIE 12.2 Exercise

MEAFORD, ONTARIO--(Marketwire -05/14/12)- Editors Note: There is a photo associated with this press release.

Today, the Honourable Steven Blaney, Minister of Veterans Affairs, joined Canadian Forces members participating in SPARTAN BEAR, a military training exercise being held in Meaford, Ontario. The exercise involves the deployment from CFB Petawawa of soldiers from 2 Canadian Mechanized Brigade Group (2 CMBG). SPARTAN BEAR provides an opportunity for the Brigade to simulate a deployment and practise a variety of combat activities in a realistic environment.

"As Minister of Veterans Affairs, I am honoured and privileged to have had the opportunity to participate in Exercise SPARTAN BEAR alongside our Canadian Forces members," said Minister Blaney. "By taking part in this exercise, I was able to see firsthand the considerable skill and ability of our service men and women."

Minister Blaney took the opportunity to meet with the soldiers of 2 CMBG. He toured the Land Force Central Area Training Centre Meaford and spent some time in the trenches with the soldiers.

By leveraging such opportunities to learn more about the Canadian Forces, Veterans Affairs Canada is gaining valuable insight into the military experience, which will help the Department provide better service to Veterans.

"Veterans have the right to receive service from people who understand the military culture," said Minister Blaney. "We will keep on working with the Canadian Forces so we continue to foster knowledge, respect and honour for the military experience. This is further proof that our Government is listening to Veterans."

For information on programs and services available from Veterans Affairs Canada, visit http://www.veterans.gc.ca.

To view the photo associated with this press release, please visit the following link: http://www.marketwire.com/library/20120514-SPARTAN_800.jpg

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Minister Steven Blaney Participates in Exercise SPARTAN BEAR

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Theres no doubt that exercise burns calories. So why has study after study found such modest average weight loss even after subjects follow relatively vigorous, well-designed exercise programs?

The usual answer is that you unwittingly eat more to compensate for your workout. Thats partly true, but it skims over a vital detail: Few of us are average. Break down the study results, and you find that exercise is highly effective at melting off pounds for some people, and ineffective for others. Scientists are now teasing out the factors that explain these different responses and poking holes in weight-loss plans that promise one-size-fits-all success.

Theres currently a strong interest in identifying behavioural phenotypes within the obese population so that treatments can be more specifically targeted, says Graham Finlayson, a biological psychologist at the University of Leeds. This is the case for exercise, food, diet, pharmacologic and surgical approaches.

The wide variability in response to exercise is shown clearly in the results of a 12-week program of supervised exercise, published in a review co-authored by Dr. Finlayson in the British Journal of Sports Medicine last month. Although the intensity and duration of each workout was the same for all 58 subjects, some lost more than 10 kilograms while others actually gained a small amount of weight opposite extremes from the average loss of 3.2 kilograms.

Dr. Finlayson and his colleagues suggest a long list of possible reasons for the variation. There are physiological possibilities, like the rate at which food leaves your gut; the production of appetite hormones like leptin and ghrelin; and the extent to which your body relies on fat versus carbohydrate for energy. All of these are affected by exercise and could influence appetite and food intake, though the evidence remains contradictory.

More recently, researchers have turned to the brain for clues. Another study by Dr. Finlayson and his colleagues, published last year in the Journal of Obesity, tested the food-reward responses of obese and sedentary subjects before and after a 12-week supervised exercise program. The food-reward test involved looking at pictures of different kinds of food before and after an exercise bout, and answering questions about their levels of desire in response to each picture.

After the 12-week exercise program was finished, the researchers divided the data into two groups based on how much weight theyd lost: the responders, whod lost an average of 5.2 kilograms; and the non-responders, with an average of 1.7 kilograms.

Sure enough, the difference between the two groups was clear even in the data collected before the exercise program had started. While the responders food-reward ratings had shown no change before and after a workout, the non-responders had shown a significant jump in desire for food, and particularly for high-fat and sweet food, immediately after working out.

Of the 34 subjects in the study, 14 (or 41 per cent) were classified as non-responders; but its not known how widely this response is found in the general population and nor is it clear whether the differences are innate or learned.

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Why exercise may not lead to weight loss

The prevalence of type 2 diabetes in Australia could be reduced by programs targeting high-risk groups.

More than 2 million Australians, 11.4 per cent of the population, will have diabetes by 2025 if current trends continue, according to Melbourne's Baker IDI Heart and Diabetes Institute.

However, modelling by the institute's researchers shows 220,000 fewer people would develop type 2 diabetes by 2025 if intensive diet and exercise programs targeted high-risk groups.

This would drop the prevalence of type 2 diabetes to 10 per cent of the population by 2025.

The modelling is based on intensive behavioural modification programs, which typically include six counselling sessions on diet and physical activity with the aim of achieving weight loss of more than five per cent over a year.

Introducing a junk food tax for the whole population and bariatric surgery for morbidly obese people with diabetes could push the number of cases prevented to 253,000, the researchers found.

Researcher Jonathan Shaw said all three strategies were beneficial but the one that had the biggest impact was the lifestyle intervention for high-risk people.

Prof Shaw said while there was no capacity to launch such a large-scale program for Australians at risk of developing type 2 diabetes, the research showed what the best approach could be to tackle the disease.

'It's telling us ... if we work towards getting close to something like that, we would have a major impact on the numbers of people developing diabetes,' Prof Shaw told AAP.

Dr Kathryn Backholer, who will present the institute's research at the 19th European Congress on Obesity in Lyon, France, on Wednesday, said preventive efforts needed to focus on intensive lifestyle intervention programs for the best chance of reducing diabetes.

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Intervention needed for type 2 diabetes

Evelyn Clayton has seen the positive effects of community care programs for seniors from virtually all sides, but those benefits could be stymied if Gov. Pat Quinn's proposed Medicaid reforms are adopted as part of the state's 2013 budget.

The 73-year-old Peorian is a caregiver to Pearly Bonds, 15 years her senior and also of Peoria.

Clayton expressed her gratitude for agencies like Senior World, which she says provides a safe and stimulating environment for her 71-year-old brother Everett Tate, who uses the Downtown facility to stay engaged with other seniors several times a week.

"I really appreciate this program because it keeps him from being isolated and allows him to continue using his brain," Clayton said. "This is a place where he can be stimulated and socialize with others. Without it, he'd be sitting home alone all day."

Clayton joined about 30 people - caregivers, seniors and their families - Wednesday at Senior World, 719 N. Kumpf Blvd., where they heard from, among others, Bob Thiemen, executive director of the Illinois Association of Community World Program Home World Providers.

Thiemen has been lobbying against the cuts to Medicaid. Mary Patton, a volunteer lobbyist for the American Association of Retired People, joined him.

The pair stressed the need for seniors and their families who receive non-nursing home care to make their voices heard.

"I can talk (to legislators) until I'm blue in the face but guess what, I didn't put them there. You did," Thiemen said.

Patton reiterated the point: "They don't want to hear what I say, they want to hear from you. We have to get to them before they put all the little pieces together."

Those "pieces," including Medicaid reforms, are parts of the state's budget which Quinn has said he wants to see finalized by May 31.

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State cuts could affect senior care programs

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