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Jan 27

Study shows lasting benefits of weight loss and diabetes remission for the heart and kidneys – News-Medical.Net

Long Term Weight Loss Comments Off on Study shows lasting benefits of weight loss and diabetes remission for the heart and kidneys – News-Medical.Net

Researchers in the School of Population Health atRCSI University of Medicine and Health Sciences have providednew evidence of the health benefits of weight loss efforts that lead to diabetes remission fortype 2diabetespatients.

For participants in the weight-loss trial who were able to achieve remission i.e. reduce the need for medications and reduce their HbA1c levels(a measure of blood sugar control), the research found there was a 40% lower rate of cardiovascular disease and 33% lower rate of chronic kidney diseasein this group.

While previoustrials have shown that substantial weight loss using diet and lifestyle can reverse type 2 diabetes, the new researchpublished in Diabetologiais among the first to show that reversal of diabetes, in turn, affects cardiovascular and kidney disease outcomes.The researchwas ledby Professor Edward Gregg, Head of the RCSI School of Population Health.

The studycalled Look AHEAD(Action for Health in Diabetes)monitoredover 5,000 patients duringa period of 12 years.The magnitudeof risk reduction was greatest for participants with evidence of at least fouryears of remission.

Using lessons learned from this study we can help inform diabetes treatment methods andimprovequality of life for people with type 2 diabetes.It has highlighted the significance of weight loss for achieving remission from type 2 diabetes and then long-term positivecardiovascularand kidney disease outcomes

Professor Edward Gregg, Head of the RCSI School of Population Health

Over the course of the study, the effect of intensive lifestyle intervention was compared with that of diabetes support and education on cardiovascular diseaseand other long-term health conditions.It wasnoted that although 18% of participants achieved remission at some point during follow-up, the percentage of participants withcurrentremission had decreased to 3% by the 8th year of the study, underlining the challenges of keeping weight off using lifestyle interventions.

RCSI researchers collaborated on the study with colleagues Wake Forest University, Brown Universityand other study sites in the United States.

Source:

Journal reference:

Gregg, E.W., et al. (2024) Impact of remission from type 2 diabetes on long-term health outcomes: findings from the Look AHEAD study. Diabetologia. doi.org/10.1007/s00125-023-06048-6.

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Study shows lasting benefits of weight loss and diabetes remission for the heart and kidneys - News-Medical.Net

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