Search Weight Loss Topics: |
Bariatric Surgery Tied to Long-Term Cognitive Benefits – Medpage Today
Gastric bypass surgery in people with severe obesity was associated with sustained improvements in cognitive function, inflammation, and comorbidities, according to results of a cohort study in the Netherlands.
At 2 years post-surgery, neuropsychological tests showed improvements of 20% or higher in global cognition (43% of patients), ability to shift attention (40%), episodic memory (32%), verbal fluency (24%), and working memory (11%), reported Amanda J. Kiliaan, PhD, of Radboud University Medical Center in Nijmegen, the Netherlands, and colleagues.
"Lower inflammation and adipokine secretion, remission of comorbidities, higher physical activity, and better mood" may have played a role in the sustained improvement in global cognition for that subset of patients, the researchers suggested in JAMA Network Open.
Compared with baseline, improvements at 2 years post-surgery were noted for inflammation, as indicated by decreases in high-sensitivity C-reactive protein (4.77 vs 0.80 g/mL, P<0.001).
Furthermore, patients were less likely to use antihypertensives at this point (36.1% vs 16.7% at baseline), had a reduction in depressive symptoms (Beck Depression Inventory scores of 9.0 vs 3.0, P<0.001), and increased their physical activity (mean Baecke score of 7.64 to 8.19, P<0.001).
Previous studies have linked bariatric surgery-induced weight loss with improved brain function and structure, Kiliaan and co-authors noted in their study introduction.
"However, results are contradictory, underlying mechanisms remain largely unknown, and it is uncertain whether outcomes are long-lasting," they wrote. "Imbalance of adipokines and proinflammatory cytokines may be involved, as they impair CBF [cerebral blood flow] and therewith cause neurodegeneration, which may be reversible after bariatric surgery."
The researchers considered the stabilization of cerebral structures and functions the most noteworthy finding of their study.
"Despite the lower CBF in several regions, volumes of hippocampus, nucleus accumbens, frontal cortex, white matter, and white matter hyperintensities remained stable after surgery," they wrote. "Notably, the temporal cortex exhibited not only higher cortical thickness but also higher vascular efficiency after surgery, as indicated by a lower sCOV [spatial coefficient of variation]. These results highlight beneficial vascular responses occurring in conjunction with bariatric surgery. Accordingly, nucleus accumbens and parietal cortex demonstrated stable CBF and cerebrovascular efficiency."
Using data from the Bariatric Surgery Rijnstate and Radboudumc Neuroimaging and Cognition in Obesity study, Kiliaan and colleagues analyzed outcomes of 133 patients eligible for Roux-en-Y gastric bypass from September 2018 to December 2020.
Patients were ages 35 to 55 years (mean 47), with a body mass index (BMI) over 40, or a BMI over 35 with comorbidities. Most patients in the cohort (84%) were women.
Endpoints were assessed at baseline (before bariatric surgery), and at 6 months and 2 years after surgery. Kiliaan and co-authors calculated the 20% change index -- an indication of clinically meaningful and significant cognitive improvement -- at 2 years after surgery to exclude practice effects.
Patients' body weight, BMI, waist circumference, and blood pressure were all significantly lower both at 6 months and 2 years after bariatric surgery. Meanwhile, the percentage of total body weight-loss increased from a mean 27% at 6 months to 34% at 2 years (P<0.001).
At 2 years after surgery, the proportion of patients with Beck Depression Inventory scores showing mild or moderate depressive symptoms at baseline declined from 42.3% to 9.4%, and from 3.1% to 1.6%, respectively.
The group noted that the high mean baseline score of 27 on the Montreal Cognitive Assessment (MoCA) and other neuropsychological assessments suggested that "obesity did not impair cognitive performance in clinical sense."
Regarding the mechanism behind the observed cognitive improvements during the study, "stabilization of volume, CBF, and sCOV in brain regions, together with larger cortical thickness and higher vascular efficiency in the temporal cortex, might be involved," Kiliaan and colleagues suggested.
Limitations acknowledged by the authors included the lack of a control group, an unequal sex distribution (although representative of the general bariatric surgery population), and failure to include cortical surface and curvature parameters, which they noted "could improve our understanding of change in cortical volume and thickness after bariatric surgery."
Kate Kneisel is a freelance medical journalist based in Belleville, Ontario.
Disclosures
The study funded by a grant from the Rijnstate-Radboudumc Promotion Fund and others.
Kiliaan reported no disclosures. Co-authors reported relationships with Dutch Top Sector Life Sciences and Health and the GLoBAL-1 consortium (Netherlands Organisation for Applied Scientific Research TNO, Radboud University Medical Center, Rijnstate Hospital, and Nordic Bioscience), among others.
Primary Source
JAMA Network Open
Source Reference: Custers E, et al "Long-term brain structure and cognition following bariatric surgery" JAMA Netw Open 2024; DOI: 10.1001/jamanetworkopen.2023.55380.
See more here:
Bariatric Surgery Tied to Long-Term Cognitive Benefits - Medpage Today
- Part 6 : Master Your Mind For Long-Term Weight Loss with Eric Viskovicz [Last Updated On: June 12th, 2011] [Originally Added On: June 12th, 2011]
- Part 7 : Master Your Mind For Long-Term Weight Loss with Eric Viskovicz [Last Updated On: June 13th, 2011] [Originally Added On: June 13th, 2011]
- LapBand for weight loss, gastric bypass alternative, obesity [Last Updated On: June 13th, 2011] [Originally Added On: June 13th, 2011]
- Part 2 : Master Your Mind For Long-Term Weight Loss with Eric Viskovicz [Last Updated On: June 13th, 2011] [Originally Added On: June 13th, 2011]
- Part 3 : Master Your Mind For Long-Term Weight Loss with Eric Viskovicz [Last Updated On: June 14th, 2011] [Originally Added On: June 14th, 2011]
- Best Diet Plan for Weight Loss with Meal Plans and Easy Recipes [Last Updated On: June 15th, 2011] [Originally Added On: June 15th, 2011]
- Dr. Val's Tips For Long-Term Weight Loss [Last Updated On: June 15th, 2011] [Originally Added On: June 15th, 2011]
- Find The Real Cause Behind Your Personal Weight Problem. [Last Updated On: June 16th, 2011] [Originally Added On: June 16th, 2011]
- Want Long Term Weight Loss [Last Updated On: June 16th, 2011] [Originally Added On: June 16th, 2011]
- Your Emotions and Beliefs Influence Weight Loss [Last Updated On: June 17th, 2011] [Originally Added On: June 17th, 2011]
- Part 5 : Master Your Mind For Long-Term Weight Loss with Eric Viskovicz [Last Updated On: June 18th, 2011] [Originally Added On: June 18th, 2011]
- Long Term Weight Loss Success After Bariatric Surgery [Last Updated On: June 18th, 2011] [Originally Added On: June 18th, 2011]
- How to Lose Weight While Eating Your Favorite Foods, Diet Solution [Last Updated On: June 19th, 2011] [Originally Added On: June 19th, 2011]
- POSE - Incisionless Weight Loss Surgery | Primary Obesity Surgery Endoluminal [Last Updated On: June 19th, 2011] [Originally Added On: June 19th, 2011]
- Long Term Weight Loss - Realize Band Surgery Houston TX [Last Updated On: June 19th, 2011] [Originally Added On: June 19th, 2011]
- My personal weight loss journey success story -- PART 1 [Last Updated On: June 20th, 2011] [Originally Added On: June 20th, 2011]
- Weight Loss , The 9 Day Body Cleansing Plan Followed By Our Long Term Weight Loss Programme [Last Updated On: June 21st, 2011] [Originally Added On: June 21st, 2011]
- Achieve Permanent Weight Loss with a Healthy Diet [Last Updated On: June 22nd, 2011] [Originally Added On: June 22nd, 2011]
- Best Diet Plan for Weight Loss with Meal Plans [Last Updated On: June 23rd, 2011] [Originally Added On: June 23rd, 2011]
- Part 1 : Master Your Mind For Long-Term Weight Loss with Eric Viskovicz [Last Updated On: June 24th, 2011] [Originally Added On: June 24th, 2011]
- Tips for Successful Long Term Weight Loss [Last Updated On: June 26th, 2011] [Originally Added On: June 26th, 2011]
- Best Diet Plan for Weight Loss (Meal Plans and Recipes) [Last Updated On: June 26th, 2011] [Originally Added On: June 26th, 2011]
- Evita Slimsonic - Speed up metabolism, achieve long-term weight loss and body slimming EMS [Last Updated On: June 27th, 2011] [Originally Added On: June 27th, 2011]
- Staying On Track For Long Term Weight Loss [Last Updated On: June 27th, 2011] [Originally Added On: June 27th, 2011]
- Wellspring Weight Loss Camps (Part 2) [Last Updated On: June 29th, 2011] [Originally Added On: June 29th, 2011]
- Part 4 : Master Your Mind For Long-Term Weight Loss with Eric Viskovicz [Last Updated On: July 4th, 2011] [Originally Added On: July 4th, 2011]
- Wellspring Weight Loss Camps (Part 1) [Last Updated On: July 4th, 2011] [Originally Added On: July 4th, 2011]
- Inexpensive Weight Loss That Works For Life [Last Updated On: July 5th, 2011] [Originally Added On: July 5th, 2011]
- Long Term Weight Loss [Last Updated On: July 13th, 2011] [Originally Added On: July 13th, 2011]
- 65 Pounds Weight Loss [Last Updated On: July 14th, 2011] [Originally Added On: July 14th, 2011]
- HowDoesProteinHelpYouBurnFat [Last Updated On: July 15th, 2011] [Originally Added On: July 15th, 2011]
- DoesFatMakeYouFat.mp4 [Last Updated On: July 18th, 2011] [Originally Added On: July 18th, 2011]
- Weight Loss Myths [Last Updated On: July 19th, 2011] [Originally Added On: July 19th, 2011]
- How to lose weight : My 5 Long-term weight loss steps [Last Updated On: July 22nd, 2011] [Originally Added On: July 22nd, 2011]
- staying on track for long term weight loss pptx [Last Updated On: July 24th, 2011] [Originally Added On: July 24th, 2011]
- Be Fit Easy Weight Loss Clinic [Last Updated On: July 29th, 2011] [Originally Added On: July 29th, 2011]
- Lose Weight in 7 Days... [Last Updated On: July 31st, 2011] [Originally Added On: July 31st, 2011]
- Coach Carla Weight Loss Introduction [Last Updated On: July 31st, 2011] [Originally Added On: July 31st, 2011]
- Weight Loss Help and Healthy Eating Part 8 [Last Updated On: August 1st, 2011] [Originally Added On: August 1st, 2011]
- tip of the day- step out of your box [Last Updated On: August 1st, 2011] [Originally Added On: August 1st, 2011]
- diet plan for weight loss #2 M8.mp4 [Last Updated On: August 10th, 2011] [Originally Added On: August 10th, 2011]
- The Ultimate Diet Plan.mp4 [Last Updated On: August 11th, 2011] [Originally Added On: August 11th, 2011]
- Discover America's #1 Hottest [Last Updated On: August 13th, 2011] [Originally Added On: August 13th, 2011]
- Lite For Life Weight Loss Review - Dietspotlight.com [Last Updated On: August 17th, 2011] [Originally Added On: August 17th, 2011]
- Raw Food Diet Weight Loss [Last Updated On: August 27th, 2011] [Originally Added On: August 27th, 2011]
- MEGA T GREEN TEA WATER WEIGHT LOSS PILL Review - Dietspotlig [Last Updated On: August 31st, 2011] [Originally Added On: August 31st, 2011]
- The long term physical side effects of anorexia [Last Updated On: September 4th, 2011] [Originally Added On: September 4th, 2011]
- Lose Weight While Building Community With Medi-Weightloss Clinics! [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- Find Long Term Fat Loss Success Retreat With Fast Track Friends [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- Weight Loss Journey. Episode 1, The weigh in. [Last Updated On: September 6th, 2011] [Originally Added On: September 6th, 2011]
- Weekly Weight In #1 [Last Updated On: September 9th, 2011] [Originally Added On: September 9th, 2011]
- RxLite Weight Control Weight Loss Fat Loss Diet Program [Last Updated On: September 9th, 2011] [Originally Added On: September 9th, 2011]
- Dr. Oz on Weight Loss [Last Updated On: September 10th, 2011] [Originally Added On: September 10th, 2011]
- Bariatric or Weight Loss Surgery Regain: Counseling to Challenge the Regain Boomerang [Last Updated On: September 12th, 2011] [Originally Added On: September 12th, 2011]
- Does Quick Weight Loss Always = Short Term Results w/ Long Term Consequences? [Last Updated On: September 13th, 2011] [Originally Added On: September 13th, 2011]
- # 1 weight loss tip [Last Updated On: September 14th, 2011] [Originally Added On: September 14th, 2011]
- Dr Mike's Weekly Health Tip - Effective, Long Term Weight Loss [Last Updated On: September 16th, 2011] [Originally Added On: September 16th, 2011]
- Long-term Weight Management [Last Updated On: September 19th, 2011] [Originally Added On: September 19th, 2011]
- Azithromycin uses [Last Updated On: September 20th, 2011] [Originally Added On: September 20th, 2011]
- Christopher Hitchens on Thomas Paine's Rights of Man (2/4) [Last Updated On: September 21st, 2011] [Originally Added On: September 21st, 2011]
- Make Your Picks (Comment) for Medi-Weightloss Clinics [Last Updated On: September 21st, 2011] [Originally Added On: September 21st, 2011]
- Jerome's Medi Weightloss Clinics Story [Last Updated On: September 21st, 2011] [Originally Added On: September 21st, 2011]
- 30 day Healthy Weight Loss Challenge [Last Updated On: September 22nd, 2011] [Originally Added On: September 22nd, 2011]
- Jiva Ayurveda and Weight Loss OR Obesity TV Shows [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- FAST, Easy Weight Loss. NO HUNGER! [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- The HMR Program for Weight Management™ at Harvard Vanguard Success Story - Michelle [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- 100+ lbs lighter xenical weight loss journey and still dumped why? [Last Updated On: September 26th, 2011] [Originally Added On: September 26th, 2011]
- Lose Weight Fast in 30 days [Last Updated On: September 26th, 2011] [Originally Added On: September 26th, 2011]
- Body By Vi Shakes Testimonies [Last Updated On: September 27th, 2011] [Originally Added On: September 27th, 2011]
- 180 Metabolism Weight Loss Audio Seminar [Last Updated On: September 28th, 2011] [Originally Added On: September 28th, 2011]
- Almased, Healthy, Natural Weight-Loss System.flv [Last Updated On: September 29th, 2011] [Originally Added On: September 29th, 2011]
- Weight loss massage [Last Updated On: October 1st, 2011] [Originally Added On: October 1st, 2011]
- Weight Loss Surgery (Part 1) [Last Updated On: October 2nd, 2011] [Originally Added On: October 2nd, 2011]
- relaxing weight loss hypnosis session [Last Updated On: October 2nd, 2011] [Originally Added On: October 2nd, 2011]
- Mealformation Food Diary - Weight Loss [Last Updated On: October 3rd, 2011] [Originally Added On: October 3rd, 2011]
- Yog Shakti - Siddhaasan - For Weight Loss, To Cure Backache [Last Updated On: October 3rd, 2011] [Originally Added On: October 3rd, 2011]
- Weight Loss Tips and Tricks with PCOS (anyone can use these, though) [Last Updated On: October 4th, 2011] [Originally Added On: October 4th, 2011]
- Almased a healthy, natural weight loss phenomenon with proven results [Last Updated On: October 4th, 2011] [Originally Added On: October 4th, 2011]
- Woman loses 115 lbs of phentermine, Topamax and Lexapro with Robert Skversky, MD [Last Updated On: October 4th, 2011] [Originally Added On: October 4th, 2011]
- The HMR Program for Weight Management™ at Harvard Vanguard Success Story - Tim [Last Updated On: October 4th, 2011] [Originally Added On: October 4th, 2011]