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Featured Article Academic Journal Main Category: Nutrition / Diet Also Included In: Endocrinology;Biology / Biochemistry Article Date: 10 Sep 2012 - 3:00 PDT

Current ratings for: Soy Diet May Lessen Anxiety Effect Of BPA On Genes

These are the findings of an animal study led by researchers at North Carolina State University who write about their findings in a paper published online in the open access journal PLoS ONE on 5 September.

BPA is an organic industrial chemical that is controversial because it has hormone-like properties similar to those of estrogen. BPA is used to make a range of polycarbonate plastics and epoxy resins, and has been present in many hard plastic bottles and metal-based food and beverage cans since the 1960s.

Lead author Heather Patisaul, an associate professor of biology at NC State, told the media:

"We knew that BPA could cause anxiety in a variety of species, and wanted to begin to understand why and how that happens."

Two other groups of rats, one fed on soy-free, the other on a soy-rich diet, were not exposed to BPA, plus the fifth group was exposed to estrogen (ethinyl estradiol), and a soy-free diet.

Tests showed that the rats exposed to BPA had blood levels within the range found in humans. They also showed that those fed a soy diet had levels of genistein, an estrogen-like compound present in soy, within the range found in humans who follow a vegetarian diet and eat soy foods on a regular basis.

And, for the first time, the researchers found the raised anxiety was linked to changes in gene expression in the brain.

The gene expression changes were in a region of the brain that is known to play a part in influencing responses to fear and stress: the amygdala.

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Soy Diet May Lessen Anxiety Effect Of BPA On Genes

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