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Apr 17

Obesity, but not high-fat diet, is associated with bone loss that is … – Nature.com

Arandjelovic, S. et al. Elmo1 signaling is a promoter of osteoclast function and bone loss. Nat. Commun. 12, 4974 (2021).

Article CAS PubMed PubMed Central Google Scholar

Tysoe, O. Melatonin prevents diabetes mellitus-induced bone loss. Nat. Rev. Endocrinol. 17, 707707 (2021).

Article CAS PubMed Google Scholar

Yu, W. et al. Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss. J. Clin. Investig. 131, e140214 (2021).

Article CAS PubMed PubMed Central Google Scholar

Bashiruddin, N. K. et al. Development of cyclic peptides with potent in vivo osteogenic activity through rapid-based affinity maturation. Proc. Natl Acad. Sci. USA 117, 3107031077 (2020).

Article CAS PubMed PubMed Central Google Scholar

Chevalier, C. et al. Warmth prevents bone loss through the gut microbiota. Cell Metab. 32, 575590 (2020).

Article CAS PubMed PubMed Central Google Scholar

Li, X. Q. et al. Targeting actin-bundling protein L-plastin as an anabolic therapy for bone loss. Sci. Adv. 6, eabb7135 (2020).

Article CAS PubMed PubMed Central Google Scholar

Pagnotti, G. M. et al. Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity. Nat. Rev. Endocrinol. 15, 339355 (2019).

Article PubMed PubMed Central Google Scholar

Estell, E. G. & Rosen, C. J. Emerging insights into the comparative effectiveness of anabolic therapies for osteoporosis. Nat. Rev. Endocrinol. 17, 3146 (2021).

Article PubMed Google Scholar

Guo, D. J. et al. Dietary interventions for better management of osteoporosis: an overview. Crit. Rev. Food Sci. Nutr. 63, 125144 (2021).

Article PubMed Google Scholar

Tanski, W., Kosiorowska, J. & Szymanska-Chabowska, A. Osteoporosisrisk factors, pharmaceutical and non-pharmaceutical treatment. Eur. Rev. Med Pharm. Sci. 25, 35573566 (2021).

CAS Google Scholar

Wang, Y. et al. Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations. Nat. Commun. 11, 5596 (2020).

Article CAS PubMed PubMed Central Google Scholar

Yang, Y. S. et al. Bone-targeting aav-mediated silencing of schnurri-3 prevents bone loss in osteoporosis. Nat. Commun. 10, 2958 (2019).

Article PubMed PubMed Central Google Scholar

Feng, W. L., Wang, X. P., Huang, D. Q., Lu, A. Q. Role of diet in osteoporosis incidence: umbrella review of meta-analyses of prospective observational studies. Crit. Rev. Food Sci. Nutr. 110 (2021).

Rizzoli, R., Biver, E. & Brennan-Speranza, T. C. Nutritional intake and bone health. Lancet Diabetes Endocrinol. 9, 606621 (2021).

Article CAS PubMed Google Scholar

Song, S. S., Guo, Y. Y., Yang, Y. H. & Fu, D. H. Advances in pathogenesis and therapeutic strategies for osteoporosis. Pharmacol. Ther. 237, 108168 (2022).

Article CAS PubMed Google Scholar

Buckley, J. Availability of high-fat foods might drive the obesity epidemic. Nat. Rev. Endocrinol. 14, 574575 (2018).

Article PubMed Google Scholar

Kumar, A. et al. High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance. Nat. Commun. 12, 213 (2021).

Article CAS PubMed PubMed Central Google Scholar

Pan, X. F., Wang, L. M. & Pan, A. Epidemiology and determinants of obesity in China. Lancet Diabetes Endocrinol. 9, 373392 (2021).

Article PubMed Google Scholar

Lian, W. S. et al. Microrna-29a in osteoblasts represses high-fat diet-mediated osteoporosis and body adiposis through targeting leptin. Int. J. Mol. Sci. 22, 9135 (2021).

Article CAS PubMed PubMed Central Google Scholar

Qiao, J., Wu, Y. W. & Ren, Y. Z. The impact of a high fat diet on bones: potential mechanisms. Food Funct. 12, 963975 (2021).

Article CAS PubMed Google Scholar

Silva, M. J. et al. Effects of high-fat diet and body mass on bone morphology and mechanical properties in 1100 advanced intercross mice. J. Bone Miner. Res. 34, 711725 (2019).

Article CAS PubMed Google Scholar

Varley, I., James, L. J., Willis, S. A., King, J. A. & Clayton, D. J. One week of high-fat overfeeding alters bone metabolism in healthy males: a pilot study. Nutrition 96, 111589 (2022).

Article CAS PubMed Google Scholar

Harasymowicz, N. S. et al. Intergenerational transmission of diet-induced obesity, metabolic imbalance, and osteoarthritis in mice. Arthritis Rheumatol. 72, 632644 (2020).

Article CAS PubMed PubMed Central Google Scholar

Hou, J. et al. Obesity and bone health: a complex link. Front. Cell Dev. Biol. 8, 600181 (2020).

Article PubMed PubMed Central Google Scholar

Lopez-Gomez, J. J. et al. Influence of obesity on bone turnover markers and fracture risk in postmenopausal women. Nutrients 14, 1617 (2022).

Article CAS PubMed PubMed Central Google Scholar

Cao, W. X. et al. The role of gut microbiota in the resistance to obesity in mice fed a high fat diet. Int J. Food Sci. Nutr. 71, 453463 (2020).

Article CAS PubMed Google Scholar

Ding, C., Guo, J. & Su, Z. The status of research into resistance to diet-induced obesity. Horm. Metab. Res. 47, 404410 (2015).

Article CAS PubMed Google Scholar

Keipert, S. & Ost, M. Stress-induced Fgf21 and Gdf15 in obesity and obesity resistance. Trends Endocrinol. Metab. 32, 904915 (2021).

Article CAS PubMed Google Scholar

Durack, J. & Lynch, S. V. The Gut Microbiome: relationships with disease and opportunities for therapy. J. Exp. Med. 216, 2040 (2019).

Article CAS PubMed PubMed Central Google Scholar

Fan, Y. & Pedersen, O. Gut microbiota in human metabolic health and disease. Nat. Rev. Microbiol. 19, 5571 (2021).

Article CAS PubMed Google Scholar

Seely, K. D., Kotelko, C. A., Douglas, H., Bealer, B. & Brooks, A. E. The human gut microbiota: a key mediator of osteoporosis and osteogenesis. Int. J. Mol. Sci. 22, 9452 (2021).

Article CAS PubMed PubMed Central Google Scholar

Ding, K., Hua, F. & Ding, W. E. Gut microbiome and osteoporosis. Aging Dis. 11, 438447 (2020).

Article PubMed PubMed Central Google Scholar

Peng, J. et al. The influence of gut microbiome on bone health and related dietary strategies against bone dysfunctions. Food Res. Int. 144, 110331 (2021).

Article CAS PubMed Google Scholar

Yan, J., Takakura, A., Zandi-Nejad, K. & Charles, J. F. Mechanisms of gut microbiota-mediated bone remodeling. Gut Microbes 9, 8492 (2018).

Article CAS PubMed Google Scholar

Li, J. Y. et al. Parathyroid hormone-dependent bone formation requires butyrate production by intestinal microbiota. J. Clin. Investig. 130, 17671781 (2020).

Article CAS PubMed PubMed Central Google Scholar

Lucas, S. et al. Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nat. Commun. 9, 55 (2018).

Article PubMed PubMed Central Google Scholar

McHugh, J. Wnt signalling in the gut microbiota-bone axis. Nat. Rev. Rheumatol. 15, 44 (2019).

Article PubMed Google Scholar

Rosser, E. C. et al. Microbiota-derived metabolites suppress arthritis by amplifying aryl-hydrocarbon receptor activation in regulatory B cells. Cell Metab. 31, 837851 (2020).

Article CAS PubMed PubMed Central Google Scholar

Hou, H. Q. et al. Gut microbiota-derived short-chain fatty acids and colorectal cancer: ready for clinical translation? Cancer Lett. 526, 225235 (2022).

Article CAS PubMed Google Scholar

Koh, A., De Vadder, F., Kovatcheva-Datchary, P. & Backhed, F. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell 165, 13321345 (2016).

Article CAS PubMed Google Scholar

Smith, P. M. et al. The microbial metabolites, short-chain fatty acids, regulate colonic T-reg cell homeostasis. Science 341, 569573 (2013).

Article CAS PubMed Google Scholar

Jia, L. M. et al. Probiotics ameliorate alveolar bone loss by regulating gut microbiota. Cell Prolif. 54, e13075 (2021). 2021.

Article CAS PubMed PubMed Central Google Scholar

Santinon, F. et al. Involvement of tumor necrosis factor receptor type II in Foxp3 stability and as a marker of treg cells specifically expanded by anti-tumor necrosis factor treatments in rheumatoid arthritis. Arthritis Rheumatol. 72, 576587 (2020).

Article CAS PubMed Google Scholar

Xie, M. X. et al. Nf-kappa B-driven Mir-34a impairs Treg/Th17 balance via targeting Foxp3. J. Autoimmun. 102, 96113 (2019).

Article CAS PubMed Google Scholar

Kondegowda, N. G. et al. Osteoprotegerin and denosumab stimulate human beta cell proliferation through inhibition of the receptor activator of NF-B ligand pathway. Cell Metab. 22, 7785 (2015).

Article CAS PubMed PubMed Central Google Scholar

Turnbaugh, P. J. et al. A core gut microbiome in obese and lean twins. Nature 457, 480484 (2009).

Article CAS PubMed Google Scholar

Barczynska, R., Kapusniak, J., Litwin, M., Slizewska, K. & Szalecki, M. Dextrins from maize starch as substances activating the growth of Bacteroidetes and Actinobacteria simultaneously inhibiting the growth of Firmicutes, responsible for the occurrence of obesity. Plant Foods Hum. Nutr. 71, 190196 (2016).

Article CAS PubMed PubMed Central Google Scholar

Massier, L. et al. Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes. Gut 69, 17961806 (2020).

Article CAS PubMed Google Scholar

Chavez-Carbajal, A. et al. Gut microbiota and predicted metabolic pathways in a sample of mexican women affected by obesity and obesity plus metabolic syndrome. Int. J. Mol. Sci. 20, 438 (2019).

Article PubMed PubMed Central Google Scholar

Galaris, A. et al. Obesity reshapes the microbial population structure along the gut-liver-lung axis in mice. Biomedicines 10, 494 (2022).

Article CAS PubMed PubMed Central Google Scholar

Liu, B. N., Liu, X. T., Liang, Z. H. & Wang, J. H. Gut microbiota in obesity. World J. Gastroenterol. 27, 38373850 (2021).

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Obesity, but not high-fat diet, is associated with bone loss that is ... - Nature.com

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