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Feb 19

Side Effects of Sermorelin Acetate (Sermorelin), Warnings …


A large proportion of patients develop anti- GRF antibodies at least once during treatment with Sermorelin. The significance of these antibodies is not clear and often a positive test at one growth assessment will become negative by the next assessment. The presence of antibodies does not appear to affect growth or appear to be related to a specific adverse reaction profile. No generalized allergic reactions to Sermorelin have been reported.

The most common treatment-related adverse event (occurring in about 1 patient in 6) is local injection reaction characterized by pain, swelling or redness. Of 350 patients exposed to Sermorelin in clinical trials, three discontinued therapy due to injection reactions. Other treatment-related adverse events had individual occurrence rates of less than 1% and include: headache, flushing, dysphagia, dizziness, hyperactivity, somnolence and urticaria.

When administered intravenously for diagnostic use, the following adverse reactions have been noted: flushing of the face, injection site pain, redness and/or swelling, nausea, headache, vomiting, dysgeusia, pallor and tightness in the chest.

The clinical pharmacology suggests that Sermorelin is very unlikely to be associated with drug abuse or dependence and there have been no reports of this from clinical trials.

Read the entire FDA prescribing information for Sermorelin Acetate (Sermorelin)

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Side Effects of Sermorelin Acetate (Sermorelin), Warnings ...

Oct 13

Sermorelin – Wikipedia


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Sermorelin - Wikipedia

Oct 12

Sermorelin – an overview | ScienceDirect Topics

Sermorelin, Somatropin, and Mecasermin Lanreotide, Octreotide and Pegvisomant

Sermorelin, somatropin, and mecasermin are given for growth hormone deficiency syndromes, and lanreotide, octreotide, and pegvisomant are used to treat growth hormone excess.

Growth hormonereleasing hormone induces the anterior pituitary to secrete growth hormone (somatotropin). Growth hormone induces its own feedback inhibition by stimulating growth hormone inhibitory hormone (somatostatin) release from the hypothalamus (Fig. 12-6). Recombinant DNA versions of growth hormone (somatotropin) can be used to treat growth hormone deficiency (dwarfism). Several different recombinant products are available and differ from in terms of route of administration (intramuscular or subcutaneous) and frequency of injection (three to seven times per week). A growth hormonereleasing hormone biologic, sermorelin (consisting of the first 29 amino acids of growth hormonereleasing hormone), is available for patients who have a hypothalamic deficiency. In addition, an insulinlike growth factor therapy, mecasermin, has been approved for children who may not necessarily have a growth factor deficiency but may be resistant to the effects of growth hormone due to the production of neutralizing antibodies to growth hormone. Mecasermin is also used for children with severe insulinlike growth factor-1 deficiency. Mecasermin is administered subcutaneously before meals to avoid a hypoglycemic response. This is yet another example of how targeting a signal transduction cascade (insulinlike growth factor-1 tyrosine kinase receptors) yields a novel therapeutic strategy.

Figure 12-6. Growth hormone feedback inhibition. GHIH, growth hormone inhibitory hormone (somatostatin); GHRH, growth hormonereleasing hormone.

In contrast, synthetic forms of growth hormone inhibitory hormone (somastatin), such as lanreotide and octreotide, are effective for managing growth hormone excess (acromegaly or gigantism). Acromegaly is often the result of a benign pituitary tumor; pharmacologic treatment is often initiated because of inadequate responses to surgery and radiation. These biologics are 40 times more potent at inhibiting growth hormone secretion than is endogenous somatostatin. However, subcutaneously administered lanreotide and intramuscularly administered octreotide are associated with abdominal cramps, reduced gallbladder contractility, gallstones, reduced serum levels of vitamin B12, and altered absorption of dietary fats. A newer, more specific therapy uses a growth factor receptor antagonist such as pegvisomant to treat acromegaly. Injection site reactions, flulike symptoms, diarrhea, and elevated liver enzyme levels can occur. Hepatoxicity must therefore be closely monitored.

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Sermorelin - an overview | ScienceDirect Topics

Oct 7

7 Sermorelin Benefits Renew Health and Wellness

Sermorelinis agrowth hormone releasing analoguethat stimulates the pituitary gland into releasing growth hormone. Essential for overall growth, cell regeneration and cell reproduction, growth hormone (GH) is especially important to children for normal development. GH not only increases a childs height but also promote bone mineralization, supports muscle mass, benefits immune system functioning and contributes to internal organ growth.1

As we age, the growth hormone releasing chemical needed to trigger the release of growth hormone from the pituitary gland declines. Adeficiency of growth hormonein adults can cause a variety of undesirable health complaints, including reduced vitality, a decrease in muscle mass, weight gain and decreased energy. In addition, growth hormone also activates production ofinsulin growth factor (IGF-1), a substance that may reduce the risk of adults developing diabetes mellitus and cardiovascular disorders.Other studies have found thatIGF-1is positively associated with cognitive functioning in older adults by providingneuroprotectiveeffectsto the prefrontal cortex and hippocampus. 2,3,4

Sermorelinis not human growth hormone but a safe and effective substance formulated to support pituitary gland health and release of growth hormone. Developed 30 years ago,Sermorelinis FDA approved to effectively and naturally treatAGHDby triggering your pituitary gland to make and release natural growth hormone.

Since the body regulates the amount of GH released, you do not experience unpleasant side effects caused by recombinant growth hormone therapy traditionally used for adult human growth hormone deficiency. In fact,Sermorelininitiates normal feedback in the body, a protective mechanism that responds to high levels of HGH by bringing levels back down naturally. This also prevents a sudden drop in hormone levels and the adverse effects caused by abruptly reduced hormone levels.5

Sermorelinis considered an anti-aging supplement that can assist the body in repairing damaged cells and weakened systems cause by insufficient HGH. Following several months of injections ofSermorelin, people start noticing the following improvements in:

Men receivingSermorelininjections may also see an increase of testosterone, which supportsSermorelinsanti-aging effects involving improved energy levels, sexual performance, and lean muscle growth.

Another advantage toSermorelinis that it offers continuing health benefits even after you have stopped injection therapy. Reinvigorated human growth production and release remains consistent or increases over time. Thats one reason whySermorelinis considered an anti-aging supplement.

Unlike recombinant human growth therapy,Sermorelinhas only a few minimal side effects, such as injection site irritation, redness and/or swelling. This irritation is similar to the skin surface issues caused by injection ofbacteriostaticwater, a type of fluid needed to reconstitute other injectable pharmaceuticals.

Extremely rare sideeffects ofSermorelintherapy include vomiting, dizziness, headache, throat/airway itching and breathing difficulties. These symptoms could indicate an allergic reaction toSermorelinthat should be treated by an urgent care or emergency room health professional.6

Doctors specializing in bio-identical hormone therapy can prescribe FDA approvedSermorelinto adults suffering symptoms of growth hormone deficiency.Diagnosing AHGD involves performing one or more of the following tests: binding protein levels, blood HGH, growth hormone stimulation,GHRH-arginine, and insulin tolerance tests. In some cases, your doctor may want to evaluate bone density using a DXA scan or want a brain MRI to assess the condition of your hypothalamus and/or pituitary gland. 7

If you think you may be experiencing symptoms of adult human growth deficiency, contact us today to learn more aboutSermorelinand how it may help you regain your vitality, energy, and quality of life.


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7 Sermorelin Benefits Renew Health and Wellness

Oct 1

What Is the Difference Between Sermorelin and Ipamorelin

Both ipamorelin and sermorelin are used to effectively treat growth hormone deficiencies by stimulating the production and release of HGH.

Technically, both ipamorelin and sermorelin are a type of growth hormone, but more accurately they are what is known as GHRPs, or growth hormone releasing peptides, sometimes also referred to as human growth hormone-releasing hormones, (GHRH) or growth hormone releasing factors (GHRF).

While the two GHRPs have much in common, they are not exactly the same thing.

These two drugs have much more in common than they have differences.

Growth hormone-releasing hormones or growth hormone releasing peptides such as Ipamorelin and Sermorelin, possess a powerful ability to stimulate the secretion of human growth hormone. They act by reacting with specific receptor cells of the pituitary gland. This is the main purpose of GHRHs as naturally produced by the body to stimulate the pituitary gland to produce and release human growth hormone (HGH) into the bloodstream. HGH is necessary to not only stimulate and regulate growth in children, but to control metabolism and cellular growth and repair, throughout our lives.

Both ipamorelin and sermorelin are prescription medicationsused to treat men and women who have been diagnosed with sub-optimal levels of growth hormone.

Sermorelin and Ipamorelin are man-made (synthetic) versions of the GHRH naturally produced by your body. They are prescription medications, used to treat patients with growth hormone deficiencies. Growth hormone-releasing hormones are large peptide hormones that differ from one another only in the number of amino acids, which can vary from 37 to 44. Both ipamorelin and sermorelin are medications that are made to duplicate the action of the naturally occurring GHRH, Ghrelin. Ghrelin is a 28-amino-acid peptide that like ipamorelin and sermorelin acts to increase growth hormone secretion.

Sermorelin is made up of 29 amino acids, therefore its chemical name is GRH 1-29. Ipamorelin is considered to be a somewhat milder GHRP than sermorelin, chemically more similar to Hexarelin and GHRP6.

Both ipamorelin and sermorelin stimulate the secretion of human growth hormone with few if any negative side effects.

As stated above, either sermorelin or ipamorelin can be used to treat low levels of HGH in the blood. Since they both are designed to boost your bodys level of HGH, they effectively have the same benefits. The differences basically lie in the different hormone receptors they react with to stimulate HGH production and release. Because of those different receptors, they can stimulate different volumes of release, over different periods of time. Your doctor will help to decide which one will produce the effects most compatible with your symptoms, goals, and lifestyle.

The following chart illustrates the differences between the two drugs

Ipamorelin Therapy

Sermorelin Therapy

Ideal age range of patients

Best used for patients from 30 50+ or those individuals with low IGF-1 levels

Best used for patients from 30 50+ or those individuals with low IGF-1 levels

How many times a day

Once or twice daily depending on specific physician instructions

Once daily at night before bedtime

How long do I have to take (months)

Minimum 9 months and as long as 12 months

Minimum 9 months and as long as 12 months

How long will results last

Once you complete a full nine months of growth hormone therapy, results should last for several months after you last injection.

Once you complete a full nine months of growth hormone therapy, results should last for several months after you last injection.

Approximate cost per month

$400 to $750 per month

$400 to $750 per month

Covered by insurance

Usually not

Usually not

How is it administered

Subcutaneous Injection

Subcutaneous Injection

Do I need a prescription



Both sermorelin and ipamorelin therapies are safe and effective, and can effectively treat and in some cases reverse the effects of age-related growth hormone decline.

To sum up, if you believe you are suffering from the negative impacts of low human growth hormone, you really could consider either option.

Speak with your doctor to decide which is right for you, based on your particular needs and lifestyle.

Of the two drugs, sermorelin tends to be slightly more potent in its effects on the body. Ipamorelin is considered to be the more gentle,gradualoption.

Both sermorelin and ipamorelin have a low risk of side effects, and can be used to treat similar symptoms and problems.

Adverse reactions: rare pain or redness at the injection site. Individual occurrence rates of less than 1% include: headache, dizziness, fatigue and rash.

No severe allergic reactions have been reported with sermorelin.

Contraindications: Neither drug should be used by individuals with a known allergy or sensitivity to the drugs.

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What Is the Difference Between Sermorelin and Ipamorelin

Oct 1

What is Sermorelin also was known as GHRP2-GHRP6 – AAI Clinic

What is Sermorelin GHRP2-GHRP6 Benefits

GHRP2-GHRP6 also was known as Sermorelin, is a growth hormone-releasing hormone (GHRH) analog used as a diagnostic agent. It is a 29-amino acid polypeptide representing the 129 fragment from endogenous human GHRH and is thought to be the shortest fully functional fragment of GHRH. It is used as a diagnostic agent to assess growth hormone (GH) secretion.

Sermorelin GHRP2-GHRP6 is a combination of human growth hormone-releasing peptides.

These medications stimulate the production of a hormone in the human brain that stimulates the body to produce its own Human Growth Hormone by the pituitary gland.

GHRPs are a group of peptides mimicking natural hypothalamic proteins, which promote the release of Human Growth Hormone (HGH) by the pituitary.

GHRP2 and GHRP6 work synergistically with Sermorelin to boost hypothalamic function, thereby stimulating the pituitary gland to increase production of the bodys own endogenous HGH and to robustly increase IGF-1 levels.

Sermorelin Acetate GHRP2 and GHRP6 are dispensed as a sterile lyophilized powder which must be reconstituted prior to subcutaneous injection. Reconstitution and handling of Sermorelin Acetate GHRP2-GHRP6 must be performed per instructions of the prescribing physician.


Growth hormone-releasing peptides (GHRPs) are a family of synthetic peptides that stimulate GH secretion. Importantly, they have no structural similarity to sermorelin or GHRH; instead, they function via receptors in the pituitary gland and/or hypothalamus. At AAI Rejuvenation Clinic, we compound two different GHRPs (GHRP2-GHRP6) into the Sermorelin mixture. The resulting mixtures, Sermorelin peptides GHRP2 and Sermorelin peptides GHRP6, are particularly potent and effective GH-inducing agents that yield comparable results to typical yet considerably more expensive HGH therapy.


GHRP-2 is a synthetic analog of the peptide hormone ghrelin. Ghrelin is a small 28 amino acid peptide that is produced by the stomach in response to hunger. It also activates the growth hormone secretagogue receptor (also known as the ghrelin receptor) to stimulate GH production and metabolism. GHRP-2 functions similarly to stimulate the hypothalamus and increase the production of endogenous GH from the pituitary gland; synthesis then slowly drops back to baseline by the third hour after administration. This more closely replicates the pulsatile nature of endogenous GH production, which makes it advantageous and potentially safer compared with synthetic HGH use.


GHRP-6 is a hexapeptide synthetic analog of met-enkephalin, which is an endogenous opioid growth factor; however, GHRP-6 does not exhibit opioid activity. GHRP-6 works similarly to GHRP-2; however, it is a first-generation GHRP that does not induce GH levels as strongly as GHRP-2. Instead, it promotes food intake by stimulating hunger and helps increase energy metabolism; therefore, it is good for patients that need to increase their food intake.

Sermorelin Injection Curious about Benefits of Sermorelin Therapy? Read more about what you can expect from this treatment and contact us for more information (866) 224-5698.


01) Increase IGF-1 levels and secretion of Human Growth Hormone02) Anti-Aging Effect, Improving03) Libido and Sexual Stamina04) Physical Performance05) Immune Function06) Muscle Mass07) The decrease in Body Fat08) Skin Elasticity09) Improves sleep quality10) Assists in recovery from traumatic injuries11) Improves eyesight and vision12) Reduces liver uptake of glucose.13) Promotes liver gluconeogenesis



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What is Sermorelin also was known as GHRP2-GHRP6 - AAI Clinic

Oct 1

Sermorelin – Palm Beach Preventive Medicine

When we are young, our pituitary gland produces growth hormone releasing factor providing our bodies with levels of growth hormone sufficient to sustain growth, health and vitality. However, as we age, the production of growth hormone releasing factor declines causing a reduction in the pituitary secretion of human growth hormone. This often leads to a growth hormone deficiency that can erode good health and diminishvitality.

Restoring optimum levels of human growth hormone may improve and maintain youthful physiology, and thereby increase the health and vitality often lost with age-related growth hormone deficiency.

Typically, AGHD (Adult Growth Hormone Deficiency) is treated by substituting natural Human Growth hormone with rHGH (recombinant human growth hormone). Though injected rHGH is still the standard treatment for treating AGHD, a breakthrough product called Sermorelin offers a more natural and affordable alternative to rHGH that is as effective.

Developed in 1998 by Serono Laboratories (the makers of Saizen) FDA approved Sermorelin has become a popular choice among physicians treating those with Growth Hormone Deficiency. Sermorelin is comprised of twenty-nine amino acids that are found in the hormone GRF1-44, a natural hormone that your brain produces to simulate the release of growth hormone.

Acting as a "releasing agent", Sermorelin triggers the pituitary gland to produce your own natural growth hormone. With Sermorelin, your body regulates the frequency and amount of HGH released, so there are none of the side effects associated with the constant introduction of injected recombinant growth hormone. What's more, Sermorelin requires no off-cycles; in fact, Sermorelin actully promotes improved pituitary gland function.


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Sermorelin - Palm Beach Preventive Medicine

Apr 29

Sermorelin vs HGH – Know The Difference | Nu Image Medical

Human Growth Hormone, also known as hGH, has been utilized in recent years as a therapy for anti-aging. This particular growth hormone, produced by recombinant gene technology, is given to help restore youthful vitality making patients feel and look younger. Even though it has been proven effective for the aging patient, supplemental human growth hormone can unfortunately lead to medical and legal problems when used. Here are some main differences with Sermorelin vs HGH.

This all being said, there may be an alternative therapy that bypasses legal restriction and medical problems Sermorelin is a form of Growth Releasing Factor (GRF). Sermorelin is a small peptide containing only 29 amino acids while hGH, on the other hand, is a large molecule containing 191 amino acids. However, studies have shown that it is only the first 29 amino acids out of the full 44 amino acids in GRF that stimulate pituitary secretion of human growth hormone. Therefore, the chemical name of Sermorelin is GRH 1-29. Sermorelin is currently the only product currently available that has the ability to enhance the effects of hGH.

In HGH Therapy, the main difference is Sermorelin is a secretagogue. This means, it is not growth hormone itself, but it actually stimulates the pituitary gland to produce more growth hormone naturally. This gives the body the benefits of hGH without giving the actual hormone. This bypass of injected hGH prevents many problems. Unlike Sermorelin, when you use hgh injections, it accumulates in the body. Levels of exogenous hormone increase for a while and then drop back down suddenly. Patients taking HGH often experience benefits for a period of time and then the effects abruptly stop. It then takes more and more medication to produce the same original effect, and taking too much can lead to severe HGH side effects. Because Sermorelin stimulates growth hormone production naturally, it is typically much more safe than hGH. With Sermorelin, the body attempts to self regulate how much or how high hormone levels can get. This type of regulation is referred to as normal feedback; a protection mechanism of the body. When levels, get too high, normal feedback mechanisms help bring levels to a more safe and steady state. This regulation of the body prevents the square wave pattern seen with hGH, thus preventing sudden drops of hormone levels.

There are over the counter secretagogues that are said to increase HGH levels much like Sermorelin. These products such as L-glutamine, L-dopa, L-arganine, L-orirnithine, glycine, ornithine alpha-ketoglutarate and herbs such as Macuna pruriens and Tribulus terrestris are amino acids that, in high doses, may elicit a small release of HGH from the pituitary. However, their effect is non-specific and typically intermittent and unreliable because they do not work on any specific receptor on the pituitary gland. High doses of amino acids can also produce kidney problems. Because Sermorelins action mimics the bodys naturally occurring growth hormone releasing process, this is not an issue.

The only method of administration currently available for Sermorelin is by subcutaneous injection. However, it is a much smaller molecule than HGH, and it may be possible in the future to administer it through the nasal mucosa with a spray form. Even though HGH and Sermorelin work at different places in the body (Sermorelin at the pituitary and HGH at the liver), the dosages are comparable. It takes the same amount of material of both products to raise the serum IGF-1. Typically, Sermorelin is prescribed in micrograms and HGH in international units (IU). Sermorelin cost is also much lower than HGH, and one vial of Sermorelin provides more daily doses than one vial of HGH. The timing of the daily Sermorelin injection is also important. Sermorelin is given once a day at bedtime. Timing the injection prior to sleep is important because Sermorelin complements the bodys natural production and release of Growth Releasing Factor during sleep.

In the battle of Sermorelin vs HGH, it is clear using Sermorelin in place of hGH has numerous benefits. It not only is cost effective and easier to obtain, but it is more importantly a more safe as well as effective supplement for increased growth hormone production within the body.

Let our team lead you in the right direction as we work together towards a healthier you!

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Sermorelin vs HGH - Know The Difference | Nu Image Medical

Apr 29

Sermorelin Side Effects in Detail –

The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content.

Applies to sermorelin: injection powder for solution

Along with its needed effects, sermorelin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking sermorelin:

Some side effects of sermorelin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer

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Sermorelin Side Effects in Detail -

Apr 21

Buy Sermorelin peptide online. Sermorelin for sale.

What is Sermorelin

Sermorelin acetate is a peptide analog of Growth Hormone-Releasing Hormone (GHRH) useful for diagnostic purposes and anti-aging treatment. Its function is the stimulation of growth hormone and seems to be a good alternative to synthetic growth hormone (HGH), which can cause adverse effects on pituitary function and it is only allowed in special cases like deficiency of this hormone on children and adults or individuals with AIDS.

Sermorelin is not a substitute for the human growth hormone (HGH) produced by the pituitary, rather it is a promoter of its natural production. The increase of HGH is accomplished by the stimulation of the pituitary giving, as a result, some benefits to individuals during the aging process.

Sermorelin promotes healthy function of the pituitary by binding to a specific receptor to increase production and secretion of endogenous HGH. The pituitary is an endocrine gland located in the hypothalamus at the base of the brain. It secretes hormones that control growth, blood pressure, the function of sex organs, thyroid glands, metabolism, pregnancy, childbirth, temperature and pain relief among others.

The main difference between Sermorelin and synthetic HGH are the side effects on bone and tissue growth abnormalities, diabetes, heart disease and cancer, whereas Sermorelin does not have any of these adverse effects. Nevertheless, people who use it may have temporary pain, redness, swelling at the place of injection, itching, and trouble in swallowing.

Sermorelin helps in the improvement of a wide variety of the body functions such as muscle mass, the bone mineral density and hence, muscle strength, exercise performance, the metabolic function, energy, libido and sexual performance, and even the improvement of quality life in general. An additional benefit in the use of Sermorelin is the stimulation of fat reduction.

This peptide can regulate the immune function, which is the protection process of an organism against diseases. This function detects any type of threats to start its self-defense and eliminate them.

Sermorelin can help in the prevention of joint deterioration and heart disease. People with arthritis can be benefited by positive results that this peptide brings in the regeneration of joint. Heart disease is related to growth hormone deficiency but if this hormone is reestablished to its optimal levels, heart health can be improved.

Although there is not enough evidence of carcinogen effects of Sermorelin, it is known that RHGH is a mitogenic hormone that can awaken latent cancers. A mitogen promotes the cell division by mitosis, which is the generation of two identical sets of chromosomes originates by a unique original chromosome contained in a cell nucleus; this process, along with by cytokinesis generates the cellular reproduction.

Some people are afraid of developing diabetes due to the use of Sermorelin but this has not been proved by the case studies, although it has been observed that improper doses of RHGH promote metabolic disorders by the alteration of chemical reactions in the body, which could generate temporary symptoms like lethargy, weight loss, jaundice, seizures or more severe permanent symptoms like diabetes.

It is important that medicated people follow their doctors instructions with accuracy because depending on the problem, doses will be suited in quantity, frequency and period.

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