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How to naturally boost testosterone levels for enhanced overall wellness  Fox News

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Lipocine (NASDAQ:LPCN) has entered a license agreement for its Tlando oral testosterone replacement therapy (TRT) with Verity Pharma.

The agreement will see Verity market Tlando in the U.S. - where it was approved in 2022 - and in Canada when it gets regulatory clearance. Verity will also hold development and commercialization rights to LPCN 1111 (Tlando XR), a "next generation" oral product candidate for TRT. It will be responsible for regulatory and marketing obligations in the U.S. and Canada.

Lipocine will get a $11M license fee and up to $259M in development and commercialization milestones. It retains rights to the Tlando franchise outside the US and Canada.

Antares Pharma - now part of Halozyme Therapeutics (HALO) - held exclusive licensing rights to Tlando at the time of the therapy's final approval by the U.S. FDA in 2022.

Shares of Lipocine (LPCN) rose as much as 12% premarket on Thursday

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Lipocine licenses Tlando testosterone therapy to Verity Pharma (NASDAQ:LPCN) - Seeking Alpha

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Prostate Risks Similar for Testosterone Therapy and Placebo  Medscape

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Prostate Risks Similar for Testosterone Therapy and Placebo - Medscape

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Testosterone Replacement Therapy and Prostate Cancer Risk  Medscape

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Testosterone Replacement Therapy and Prostate Cancer Risk - Medscape

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Undergoing HRT causes various desired outcomes, and one of the possible impacts is the changing of your vocal chords, and thus, your voice.

Hormone replacement therapy (HRT) is a vital part of the gender transition process for many transgender people. While HRT can bring about significant physical and emotional changes, one aspect that often concerns singers or aspiring musicians is its potential effect on the singing voice.

When transmasculine individuals undergo HRT with testosterone, they often experience a significant change in their voice. The hormone leads to vocal masculinisation, which involves the thickening and lengthening of the vocal cords. This results in a deeper, more traditionally masculine voice. The degree of vocal change varies from person to person.

Singers who transition through testosterone may experience challenges in adapting to their new vocal range. It may take time and effort to retrain their voice and develop new vocal techniques to accommodate the lower pitch. Some singers may lose some of their higher vocal range, but with practice and vocal training, they can still sing and perform effectively. It's important to work with a vocal coach or speech therapist who can help navigate these changes.

For people who are transfeminine and take oestrogen, this hormone primarily affects secondary sexual characteristics, such as breast development and fat distribution. Unlike testosterone, oestrogen does not have a significant effect on the voice, meaning that there are generally no significant changes to the vocal range.

To preserve your singing voice while on HRT, especially if you're taking testosterone, you can consider the following strategies:

Taking a low dose of testosterone can help preserve your singing voice compared to a full dose. A lower dose of testosterone results in less dramatic changes in vocal pitch and quality. However, it's important to note that individual factors such as genetics and the duration of hormone replacement therapy (HRT) still influence the effect of testosterone on the voice. While a lower dose might be less impactful, more is needed to guarantee a complete preservation of the original voice. Vocal training and therapy can still be valuable in adapting to any changes.

The amount of testosterone taken can impact the rate and extent of voice changes. If a lower dose is taken, the changes will be more gradual and subtle, allowing some people to maintain a voice closer to their pre-HRT voice. A full dose, on the other hand, can result in more pronounced changes, leading to a deeper, more traditionally masculine voice. However, the extent of the change can vary significantly from person to person, and even with a lower dose, some may still experience noticeable differences in their voice, though to a lesser degree.

It takes time and practice to adapt to a new vocal range. Transgender people undergoing hormone replacement therapy (HRT) should be patient with themselves and practice regularly to strengthen their voices and become more comfortable with their new range.

Regular vocal exercises and warm-ups are essential in maintaining vocal health and flexibility. These exercises can help individuals extend their vocal range and improve their vocal control.

Some people may consider voice surgery. These surgical procedures can achieve a more desired vocal pitch and quality. However, surgery is an irreversible step and should be carefully considered.

Here are some common voice surgeries:

Undergoing HRT can have an impact on a person's singing voice. However, transgender people can maintain their singing abilities and continue their passion for music with determination, vocal training, and support. It's important to understand that the effects of HRT on the voice can vary from person to person. Thus, finding what works best for you is a unique and personal journey that may require patience and perseverance. With the right guidance and effort, it is possible to harmonise your voice with your authentic self.

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How HRT impacts your voice - Will transition affect my singing? - GenderGP

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BUZZ-Lipocine rises on licensing deal for testosterone therapy in US, Canada

** Shares of drug developer Lipocine LPCN.O rise 6.5% to $4.1 premarket

** Co enters into license agreement with Verity Pharma to market its testosterone replacement therapy, Tlando, in the United States and Canada

** Under terms of the deal, co to receive a license fee of $11 million

** Co to also receive up to $259 mln in development and commercial sales milestones

** Under the agreement, Verity Pharma will be responsible for regulatory and marketing obligations in the U.S. and Canada, and all further development of the therapy

** LPCN will retain all rights to the Tlando franchise for territories outside the U.S. and Canada

** Tlando was approved by the U.S. FDA in 2022 as an oral testosterone replacement therapy in adult males for conditions associated with a deficiency or absence of endogenous testosterone

** Stock fell 58.1% in the last 12 months

Reporting by Sneha S K

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Lipocine rises on licensing deal for testosterone therapy in US, Canada - XM

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Testosterone isnt just a sex hormone. In men, it plays an important role in many other systems in the body including the heart. And when testosterone levels are abnormal, the heart can experience issues.

The strongest evidence is that abnormally low testosterone is not good cardiovascularly, says Geoff Werstuck, Ph.D., a professor of medicine at McMaster University who specializes in heart health.

In the mid-1980s, scientists measured the testosterone levels of 794 older men, and followed them for the next two decades. The results, published in 2008 in the Journal of Clinical Endocrinology and Metabolism, found that men with the lowest testosterone levels were 38% more likely to die of a cardiovascular event like a stroke or heart attack.

In another analysis, Belgian researchers aggregated results from 19 different studies on testosterone and heart health. They found that men over 70 who had high testosterone were 16% less likely to experience a cardiovascular event than men with low T.

Why do we see this relationship between testosterone and heart health? Scientists arent sure. These population studies dont necessarily show that low testosterone causes cardiovascular problems. It could be that low T is simply a symptom of poor overall health, or, as an article published in the journal Evolution, Medicine, and Public Health theorized, it could caused by another condition that tends to occur alongside heart problems. For example, heart disease is often associated with higher body fat, which in turn can lower testosterone levels.

That said, some studies do suggest a more direct relationship between testosterone and heart problems. Werstuck conducts most of his research in mice, and has found that when mice are castrated, they quickly begin showing signs of atherosclerosis hardening of the arteries that can contribute to heart problems.

We see similar patterns in men treated with androgen deprivation therapy, a treatment for prostate cancer that forces the body to produce very little testosterone. In a 2001 study comparing 26,570 men undergoing this therapy to 46,626 men with prostate cancer who didnt receive it, men receiving androgen deprivation therapy were 16% more likely to have coronary heart disease and 11% more likely to have a heart attack.

One hypothesis as to why this relationship exists is that testosterone directly impacts our genetic material in ways that decrease inflammation. Like a key fitting into a keyhole, testosterone binds to androgen receptors, which are located on most cells in the body. That grants testosterone access to DNA within the cell. It locks onto sites on the DNA that are built to interact with the hormone and changes the way the body reads and expresses that genetic code.

Experiments show that when testosterone changes gene expression, it can counter inflammation in the body. Inflammation is a state where the body releases white blood cells and chemicals to fight disease and injury good in the short term, but harmful to the heart when it becomes a chronic state.

If youre experiencing symptoms of low T such as fatigue, erectile dysfunction, low libido, depression, and loss of muscle mass it might be worth getting your levels checked. From there, have a conversation with your doctor about treatment.

But be aware that it may not protect your heart. Testosterone replacement therapy (TRT), in which synthetic testosterone is administered as an injection or topical ointment, can help raise testosterone levels, but there isnt good evidence that it reduces the risk of heart problems, Werstuck says. In fact, some studies suggest it might increase this risk. That doesnt mean you should rule out TRT, but dont spring for it without a conversation with a medical professional.

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The Worrisome Link Between Low Testosterone And Heart Problems - Fatherly

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Are Testosterone Boosters Any Effective for Muscle Gains and Increasing Testosterone Levels in Men?  EssentiallySports

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Are Testosterone Boosters Any Effective for Muscle Gains and Increasing Testosterone Levels in Men? - EssentiallySports

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Low Testosterone: Help is on the Way  Men's Journal

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Low Testosterone: Help is on the Way - Men's Journal

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Osteoporosis is a devastating bone disease characterized by progressive loss of bone mineral density and deterioration of bone tissue. This leads to weak, fragile bones that are prone to painful fractures and breakage. Fractures, stooped posture, loss of height, and back pain are common symptoms. Osteoporosis can severely impact quality of life and ability to live independently.

While various medications are used to treat osteoporosis, they have significant limitations. Most drugs simply slow the rate of bone loss but do not help build new bone. In addition, they carry risks of side effects and lose effectiveness after several years.

Exciting new research shows that sermorelin therapy has major advantages in the treatment of osteoporosis. Sermorelin is a growth hormone releasing hormone that can stimulate new bone formation. It addresses the root cause of osteoporosis declining human growth hormone production and has demonstrated the ability to reverse bone loss.

Our bones are constantly being remodeled in a balance between old bone being broken down (resorption) and new bone being formed (formation). As we age, this balance shifts and more bone is removed than replaced. Osteoporosis occurs when there is significant net bone loss over time. Some key factors that contribute to osteoporosis include:

The resulting imbalance between bone resorption and formation causes bones to become weak and porous, leading to osteoporosis.

The early stages of bone loss usually cause no symptoms. Osteoporosis is often not diagnosed until a fracture occurs. Common signs and symptoms include:

Osteoporosis puts people at high risk for debilitating fractures of the hip, wrist, and spine. These fractures can lead to chronic pain, long recovery times, loss of mobility and independence, and increased mortality. Around 30% of patients die within one year following a hip fracture.

Several types of medications are commonly used to treat osteoporosis:

Bisphosphonates like alendronate inhibit the bone resorbing activity of osteoclast cells. This slows bone loss, but does not stimulate formation of new bone. Long-term use is limited by side effects like nausea, heartburn, and bone, joint, or muscle pain. Benefits diminish after 3-5 years.

RANKL inhibitors like denosumab work similarly to bisphosphonates, reducing bone breakdown. Again, they do not build new bone and benefits wane over time.

Estrogen therapy can reduce bone loss in postmenopausal women, but increases risk of blood clots, stroke, and certain cancers.

Testosterone is sometimes prescribed for osteoporosis in men, but it carries prostate risks.

While these drugs may temporarily slow bone loss, they fail to restore normal bone remodeling and mass. More effective therapies are needed to rebuild bone and reverse osteoporosis.

Exciting research in the last decade shows that growth hormone secretagogues like sermorelin peptide can stimulate powerful regeneration of bone tissue and effectively treat osteoporosis.

What is Sermorelin?

Sermorelin is a bioidentical version of a natural hormone called growth hormone releasing hormone (GHRH). It consists of the first 29 amino acids of GHRH produced in the hypothalamus of the brain.

When injected, sermorelin stimulates the nearby pituitary gland to increase its production and release of human growth hormone (HGH). Growth hormone has wide-ranging effects throughout the body including bone remodeling.

As we age, HGH levels steadily decline. By the time we are 60 years old, we may have only 20% of the HGH we had in our youth. This decrease in growth hormone is a major factor in osteoporosis.

How Sermorelin Rebuilds Bone

Sermorelin combats osteoporosis by restoring diminished HGH levels back to a youthful range. Specifically:

In essence, sermorelin exerts its bone-building effects indirectly. By raising growth hormone and IGF-1 back to more normal levels, it triggers the bodys own osteogenic mechanisms to lay down new bone matrix and strengthen the skeletal system.

Sermorelin activates bone building in two key ways:

This cascade effect means sermorelin does not act directly on bone, but exerts its osteogenic effects indirectly by boosting declining levels of growth hormone and IGF-1 back to youthful levels.

While more research is still needed, initial clinical studies on sermorelin therapy for osteoporosis have been very promising:

Researchers concluded sermorelin shows excellent potential for treating osteoporosis and improving bone density, especially in those with low IGF-1. Larger scale, longer term studies are warranted.

Both men and women suffer from osteoporosis, though women face higher risk. Some key gender differences:

In women the rapid drop in estrogen after menopause frequently triggers significant bone loss. The thinner bones combined with female skeletal structure leads to frequent wrist, hip and spine fractures.

In men bone loss is more gradual due to slow testosterone decline. However low testosterone does contribute to osteoporosis in men. Male bone geometry leads to more pelvic and upper arm fractures.

Fortunately, sermorelin benefits both sexes by restoring diminished growth hormone levels that are crucial for ongoing bone remodeling and overall health. Studies show increased bone density and bone formation markers in both older men and postmenopausal women using sermorelin.

To get the most out of sermorelin treatment for osteoporosis, combine it with healthy lifestyle factors:

With a balanced nutrition and exercise plan, sermorelin is even more effective at increasing bone density. Patients see better results when sermorelin is part of a comprehensive osteoporosis treatment approach.

For osteoporosis treatment, sermorelin has advantages over injectable synthetic human growth hormone (hGH):

By stimulating your own pituitary gland, sermorelin peptide therapy provides a natural way to restore healthy growth hormone levels. This makes it very promising for sustaining benefits long-term without safety concerns.

Sermorelin is typically well tolerated, especially when administered properly under medical supervision. Potential side effects may include:

Rarely, sermorelin can increase blood sugar or cause dyspnea or edema in those prone to heart disease or kidney issues. Bloodwork helps identify any individual risks.

Used appropriately at moderate doses, sermorelin has an excellent safety profile. However, work closely with an experienced physician for optimal osteoporosis treatment results.

Sermorelin has considerable advantages over traditional osteoporosis medications:

With the ability to rebuild bone by stimulating new growth rather than just inhibiting loss, sermorelin is an extremely promising therapy for restoring bone strength in osteoporosis patients.

In addition to benefits for bone health, sermorelin offers a wide range of desirable anti-aging effects by elevating natural HGH levels:

This makes sermorelin an excellent overall anti-aging treatment, while also specifically addressing bone loss. The combination of increased bone density and improved physical function means sermorelin can enhance quality of life and independence for osteoporosis patients.

If you have been diagnosed with osteoporosis or are at risk due to advanced age, menopause, low testosterone, or other reasons, talk to your doctor about whether sermorelin therapy is appropriate for your situation.

Those who may benefit from sermorelin include:

Sermorelin treatment involves injecting a small dose under the skin daily, usually before bedtime when natural growth hormone is secreted. Effects build gradually over months of consistent use. Your physician will monitor your IGF-1 and hormone levels with periodic bloodwork.

Potential side effects are generally mild and may include injection site reactions, headaches, dizziness or transient joint pain. Sermorelin has an excellent safety profile, especially when managed by an experienced hormone therapy doctor. Suppliers likeElement Sarms or Pinnacle Peptides offer USA made high quality sermorelin for research use. Follow medical advice and work closely with your doctor to see if adding sermorelin to your treatment plan could help strengthen your bones and optimize wellbeing.

For those struggling with osteoporosis, sermorelin therapy in combination with a healthy lifestyle provides a way to naturally rebuild bone density, improve physical capacity, reduce risk of fractures, and enhance quality of life. Talk to your doctor to learn more and determine if sermorelin is appropriate for your situation.

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How Sermorelin helps in the Treatment of Osteoporosis - Startup.info

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