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May 11

Alzheimer’s: Ozempic and Similar Drugs May Help Decrease … – Healthline

Long Term Weight Loss Comments Off on Alzheimer’s: Ozempic and Similar Drugs May Help Decrease … – Healthline

In addition to promoting weight loss and treating diabetes, semaglutide drugs like Ozempic and Wegovy may also prevent cognitive decline.

The drugs, which belong to a class of medications called glucagon-like peptide 1 (GLP-1) agonists, work by altering the metabolic system and lowering inflammation throughout the body.

Scientists suspect this could help slow the progression of neurodegenerative diseases like Alzheimers disease and Parkinsons disease.

Trials evaluating these drugs ability to combat cognitive decline are already underway, however, results arent expected until 2025.

But given their ability to fight inflammation, a risk factor for cognitive decline, some health experts suspect they may prove useful in protecting cognition.

These drugs show great promise in slowing or preventing onset of cognitive decline in those at risk for Alzheimers disease, Dr. David Merrill, MD, PhD, an adult and geriatric psychiatrist and director of the Pacific Neuroscience Institutes Pacific Brain Health Center in Santa Monica, CA, told Healthline.

With brain diseases like Alzheimers, a protein called amyloid accumulates and forms plaques.

Over time, these plaques can affect cognitive function.

Some scientists think that diabetes drugs may prevent amyloid buildup.

Alzheimers disease has also been called diabetes type-III, so it is hopeful that in mild cognitive impairment or early-stage Alzheimers disease patients with metabolic syndrome including insulin resistance or frank diabetes will benefit from treatments for diabetes like the GLP-1 agonists, Merrill said.

Recent evidence has shown that anti-amyloid drugs, another type of medication being investigated for Alzheimers disease, may be effective at combating cognitive decline, however, those drugs come with potential serious side effects, like brain bleeding and swelling.

The hope is that semaglutide could lower the risk of cognitive decline without causing serious health complications.

Research is in the early phases and it will take years to determine if the drugs effectively prevent cognitive decline.

Novo Nordisk launched two trials in 2021 that are evaluating semaglutide in people with early Alzheimers. Those results are expected in 2025.

Other pharmaceutical companies, including Neuraly, are testing GLP-1 drugs against Parkinsons disease.

Dr. Irina Skylar-Scott, a cognitive and behavioral neurologist at Stanford Health Care, believes its important to explore novel mechanisms and identify new treatments for Alzheimers disease.

Given the complexity of the disease and prior unsuccessful clinical trials, we need to think outside the box to make strides for our patients, says Skylar-Scott.

Merrill says theres a known link between mid-life obesity and the development of later-life dementia.

Evidence shows that people who are overweight or have obesity face a greater risk of getting dementia down the road.

When obesity is treated earlier in life, the risk for dementia can drop, too.

Skylar-Scott says the role semaglutide may play in Alzheimers disease and vascular dementia is likely independent of its role in weight loss.

GLP-1 can stimulate the release of insulin, thereby improving insulin signaling, reducing inflammation and promoting survival of brain cells, says Percy Griffin, PhD, Alzheimers Association director of scientific engagement.

Some studies have shown that GLP-1 may reduce amyloid and tau accumulation in the brain.

Other reports have found that GLP-1 has anti-inflammatory effects, specifically on the pancreas, liver, vascular system, kidney, lungs, testis, and skin, says Merrill.

Given the mechanisms of action of these kinds of drugs and the biological changes associated with Alzheimers, it makes sense to examine if these drugs can slow down the progression of the disease, Griffin said.

Whether treatment late in life with a drug like Wegovy or Ozempic can benefit those who already have signs of dementia or Alzheimers disease has yet to be seen, according to Merrill.

At this time, there is not enough clinical data to support the use of these drugs in Alzheimers disease, Griffin said.

Because Alzheimers is a complex disease linked to several changes in brain biology, its unlikely that any one treatment would put a full stop to the cognitive decline, says Griffin.

Theres a strong need for an arsenal of medications and modifications that target all aspects of the biological changes to defeat this devastating disease, Griffin said.

This emphasizes the need for an arsenal of medications which target all aspects of the biological changes to defeat this devastating disease, Griffin said.

Researchers are exploring whether semaglutide drugs like Ozempic and Wegovy could help prevent cognitive decline. The drugs work by altering the metabolic system and lowering inflammation throughout the body, which may help protect brain health. Trials exploring the semaglutides impact on cognition are underway and results are expected in 2025.

Original post:
Alzheimer's: Ozempic and Similar Drugs May Help Decrease ... - Healthline

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