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ByMichael Ormsbee, PhD,Florida State UniversityEdited by Kate Findley and proofread byAngelaShoemaker, The Great Courses DailyWhen reducing calorie intake to achieve weight loss, its important not to be too extreme in the number of reduced calories or muscle mass will be lost. Photo By Isarat / ShutterstockWhat Is the Energy Balance Equation?

You can manage your weight with the energy balance equation. This equation consists of three conditions: energy balance (the calories you take in match the calories that you expend or burn), positive energy balance (you eat more calories than expended), and negative energy balance (where more energy is expended than you take in).

Theoretically, if you are in energy balance, you will not lose or gain any weight. In a positive energy balance, you will gain weight, while in a negative energy balance, you will lose weight.

Either way, whether positive or negative energy balance, numerous changes occur to your bodycellularly, metabolically, and hormonallyto facilitate weight gain or loss. As an example, lets consider extreme weight loss where morbidly obese people are placed on medically supervised diets as an alternative to gastric bypass surgery. Morbidly obese is defined as a body mass index (weight to height ratio) above 40, or having over 100 excess pounds (lbs) of fat. In this example, a female who is five feet tall might weigh 205 lbs or more.

When put on very low-calorie, medically monitored diets of 800 calories per daywhich believe it or not is the common medical treatment at bariatric centers in the United Statesthe individuals lost a massive amount of weight. On average, about 40 lbs or more is lost in an approximate 12-week treatment period.

Here is the problem, though. That weight loss is not only coming from fat. In this example, the 40-lb weight loss is usually about 75% fat and about 25% muscle.

That 25% loss of muscle mass is not desirable; and for this reason, new research, including my own, seeks ways to modify these medically supervised, very low-calorie diets to get the most weight loss from fat while keeping as much muscle as possible, Professor Ormsbee said.

Keep in mind that an 800-calorie diet is only recommended under medical supervision. For the average person, Professor Ormsbee suggests dietary strategies to improve weight loss without sacrificing muscle.

This includes regular exercise and some specific dietary habits, such as increasing protein intake. Regardless, when it comes to energy balance, we should pay attention to how many calories we eat and drink to begin losing or gaining weight, and the patterns may surprise you.

Lets start with a simple question: How many calories do you need to cut from your diet to lose weight? Taking it one step farther, how many calories will it take to lose just one pound?

For years, textbooks and experts have asserted that one pound of fat is equivalent to 3,500 calories. Thus, if you aim to lose one pound of fat per week by modifying your diet alone and not considering exercise, then you would eat 500 less calories per day for one week. Thats pretty easy to wrap your mind around; just skip a daily dessert or an extra serving at dinner.

You might start thinking that if you eat 500 calories less per day and lose one pound per week, you could up this to a reduction of 1,000 calories per day and lose two to three lbs per week. However, the more is better mantra does not always suit us well with diet and exercise.

Recall the example about weight loss coming from both fat and muscle. It turns out that if your energy deficit is over about 1,000 calories per day, it is generally not well tolerated. This is due to many factors, but primarily when you drop your calories by too much, you will also lose musclewhich you do not want.

Too great a calorie deficit also runs a greater risk of missing out on key nutrients, like your vitamins and minerals, and you would likely see your energy levels drop and your fatigue increase. Not to mention, youll probably feel hungry.

One myth that has arisen from this 3,500-calorie rule is that weight will simply continue to drop at the same rate, otherwise known as the linear model of weight loss. In an article in the International Journal of Obesity, the authors studied the accuracy of the 3,500-calorie rule. As it turns out, the rule actually overestimates weight loss, meaning that 3,500 calories may translate to less than one pound lost.

Thus, an update was made. The new model for weight loss, called the thermodynamic model or simply the dynamic model of weight loss, takes into consideration your baseline body composition, age, height, sex, and degree of calorie restriction.This model results in a curvilinear pattern of weight loss over time rather than the traditional linear model of weight loss, and is much more accurate in actual trends for weight loss.

Michael Ormsbee is an Associate Professor in the Department of Nutrition, Food, and Exercise Sciences and Interim Director of the Institute of Sports Sciences and Medicine in the College of Human Sciences at Florida State University. He received his MS in Exercise Physiology from South Dakota State University and his PhD in Bioenergetics from East Carolina University.

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Lose Weight and Stay Sane This Season! The Energy Balance Equation - The Great Courses Daily News

Youprobably have a chunkof ginger root sitting in the bottom of a drawer in your fridge,ready to be shaved into action. Add it to hot water to drink as a natural elixir, or use it to addsome kicky flavor to stir-fries or smoothies. But there are so many more reasons to bring ginger into your daily diet, and they range from quelling an upset stomach to helping fight off infections, chronic disease, and even sneaky cancer cells growing somewhere in your body.

The strong, bitter taste and strange-lookingroot is a rare all-in-one natural remedy that is easy to buy, cheap to acquire, and may just have super-powers against every type of infection if the studies are to be believed. Scientists have written extensively on the miracle root's properties, used as a "nutraceutical" or food as medicine, for centuries the world over.

Gingerol, the active ingredient in ginger, isa powerful antioxidant, with anti-inflammatory properties, and anti-cancer properties and helps to help protect your body frominfections and lower inflammation that is the marker of chronic diseases, such as osteoarthritis. In addition, gingerol promotes longevity because it's known to fight cellular stress that causes aging.

Without overwhelming you with the scientific evidence, we looked at the sevenscientifically provenhealth benefits of ginger, and cite the studies that show the powerful properties it possesses. In addition, below are 5 of our favorite plant-based recipes that call for ginger, so you can enjoy the incredible health benefitspacked into every bite. Or,boil 4 cups ofwater and grate half of a teaspoon of gingerand let it steep for 10 minutesand sip your ginger tea throughout the day.

One major study finds that"Ginger contains many phenolic compounds such as gingerol, shogaol, and paradol that exhibit antioxidant, anti-tumor, and anti-inflammatory properties"which means it can fight everything from tumor cells to inflammation, which is often at the root of other chronic diseases. The health benefits of ginger are so powerful that when you inhale the strong, bitter aroma of the gingerol in your tea, you should associateit with healing.

Ginger is used as a natural remedy to help alleviate pain andstrengthen your immune system to help fight illnesses, ranging from infections to digestive disorders. If you're experiencing inflammation, which can show up as digestive stress, bloating or aches and pains inany area of the body, try adding ginger to your dailymorning drink.

6-Gingerol, the active component of ginger, has the ability to lower inflammationin the body according to one majorstudy. Gingerolis also usedfor medical purposes against symptoms of nausea, arthritis, and pain.

Inflammation in the body is often triggered by an infection but doctors will tell you that when chronic inflammation sets in that can accelerate the aging process and lead to a cascade of unhealthy events in the body including weight gain, high blood pressure and more. So taking ginger will help alleviate inflammation, which is turn will allow your cells to become healthier.

For foods that fight inflammation see this story. On the flip side, red meat, dairy and animal protein are known to promote inflammation, so a diet of whole plant-based foods will help fight inflammation, lower risk of disease and prevent infection.

Ginger has been used as an herbal medicine for decades, in particular, to fight oral and respiratory infections such as gum disease and viral infections like colds and flu.

The "gingerol compounds contain antimicrobial and anti-fungal properties,as well as several pharmaceutical properties," according to astudythat looked at the power of fresh ginger.

Sipping fresh ginger tea is effectiveforprotecting against gumbacteria likegingivitis and periodontitis, according to the study. These oral bacterias can causeperiodontal disease, an infection of thegums.

Another study found that fresh ginger has anti-viral activity against the respiratory syncytial virus (RSV), a common respiratory infection that can be serious among old people and babies. In a time of COVID-19, respiratory health is especially important and "fresh, but not dried, ginger is effective" againstthe type ofplague that canblock lung function.

Gingerol may promote weight loss by reducing inflammation and lowering lipid accumulation in the body, according to studies that show ginger may be a natural weight-loss supplement.

In onestudy, obese rats were treatedwith gingerol for 30 days, and fed a high-fat diet. Research showed "significantly decreasedglucose levels," as well as body weight, leptin and insulin, two hormones that help regulate fat storage in the body. Essentially the rats on ginger had much healthier response to the food they ate than those not given the ginger.

In anotherstudy,473 overweight subjects were placed in randomized controlled groups and half consumed ginger supplements to see what the effect of ginger would be on weight loss. "Ginger intake reduced body weight, waist-to-hip ratio ... fasting glucose and insulin resistance" and helped to boost HDL "or good"cholesterol, according to the findings.

Another studylooked at the effects of taking dietary supplements for green tea, capsaicin and ginger extracts especially what impact these three supplements would have on weight loss. After 8 weeks on the supplements, 50 overweight women"had beneficial effects on weight, BMI, markers of insulin, metabolism." So while ginger was part of the study, it appears to be beneficial both on its own and taken together with green tea and capsaicin(found in chili peppers).

Gingerol has been shown tohelp reduce oxidative stress, which causes aging on a cellular level. Antioxidants fight the damagingresults of free radicals in the body, according to a study.If you're feeling overwhelmed, try sipping hot water with lemon and ginger to help releasethe antioxidants into your system and start to combat all that cellular stress and reduce inflammation.

One studyfound that the compound gingerolpromotes longevity and could extend lifespan. The studyfound "lifespan extending" properties of ginger," mostly by fighting off diseases and slowing the aging process itself.

Yet another study suggests that gingerol " has anti-inflammatory and anti-oxidative properties for controlling the process of aging" by fighting a variety of diseases, including cancer. The study states: "The anticancer potential of ginger is well documented and its functional ingredients like gingerols, shogaol, and paradols are the valuable ingredients which can prevent various cancers."

Ginger may reduce "tumorigenic risk factors," according to several studies. In addition, ginger supplements may help alleviate the side-effects of chemotherapysuch asnausea, cramps or pain,according to a study.For best use,studies recommend takinga supplement but always consult your doctor before deciding this or any course of treatment for cancer or side effects.

"The active compound of ginger has proven its role in cancer management" according to yet anotherstudy,through its tumor suppressor genes, and its ability tocut offbloodsupply to tumors which in turn diminishes their ability to grow."

The powerhouse compound in ginger, gingerol, contains "anti-tumorigenic activities," and may be effective in controlling the ability of certain cancers to grow: Colorectal, gastric, ovarian, liver, skin, breast, and prostate cancers, according to anotherstudy.

While you should always follow your doctor's advice for treatment, adding ginger to your smoothie or sipping it in a juice may help alleviate inflammation and add natural strength to other therapies you are taking.

Ginger is an anti-inflammatorythat helps to reduce pain related to arthritis. If you're experiencing joint pain, back pain, or have osteoarthritis, ginger may be a natural way to reduce swelling which will take pressure off the nerves and lower your pain. calm the nerves.

One study assessed the clinical efficacy and safety of oral ginger for treatments of osteoarthritis. The participants who consumed ginger found "a statistically significant pain reduction," compared with those who didn't get the ginger supplement.

In another study, an herbal formulation that included ginger, turmeric, and black pepper was measured for effectiveness versusNaproxen, an anti-inflammatory drug sold as Aleve . Sixty patients with knee osteoarthritis were studied. Individuals were randomly assigned to receive daily turmeric extract, ginger, and black pepper together or Naproxen capsule for 4 weeks. The findings discoveredthat both groups significantly reduced knee pain, however, there were nosignificant differences between groups, meaning that ginger, turmeric and black pepper did just as well to reduce swelling and pain as the over-the-counter pain killer.

Ginger supplements have been shown to reduce the level of fasting blood sugars, whiich has implications for weight loss and diabetes or pre-diabetes. Inastudy, 41 subjects with type 2 diabetes were assigned to take ginger or placebo for 12 weeks. Results found that"ginger supplementation significantly reduced the levels of fasting blood sugar and A1c, which is a significant measure of how well insulin is working to helpregular blood sugar and keep your body healthy."It seems that oral administration of ginger powder supplement can improve fasting blood sugar, hemoglobin A1c... in type 2 diabetic patients," the study found.

1.Spiced Oats Bowl With Apples and Ginger

Why We Love It:Porridge is ahealthy and quick option for breakfast. Oats are nourishing, and when you mix it with fruit, plant-based milk, and spicesthis is a breakfast bowl with protein, minerals, vitamins, and enzymes.

2.Vegetable Ginger Potstickers with Shiitake Napa Cabbage & Carrots

Why we love it:Potstickers are an easy and fun recipe to make, you can use almost any time of vegetable for this dish. This recipe, in particular, is full of flavor and has an Asian twist that tastes incredible. The dumpling wrap is small and thin, so this recipe is extremely low in calories and sugar.

3.Spicy Sesame Ginger Tofu

Why we love it: Thisdish is its high in protein, super filling, and you can make it in advance! If you aren't a fan of tofu you can use tempeh, chickpeas, ormeatlesschicken strips.A lot of the flavor of this dish will come from the Spicy Sesame Ginger sauce, which is as simple to make as combining everything in one bowl and mixing.

4.Citrus Juice Blend Packed with Vitamin C

Why we love it:Thisimmunity-boostingjuice is quick and easy to make, requires just 10 minutes, a cutting board, and a blender. Don't let your produce go bad, you can store this mix in your fridge for up to 3 days and re-blend it forthe next time you need to feel refreshed and energized.

5.Vegan Chana Masala

Why we love it:Chana Masalais a classic Indian dish that just so happens to be vegan! Youll see a lot of curries usuallycontain coconut milk, which gives the curry a creamy texture. However, chana masala doesnt use any coconut milk, which gives the dish more of a stew-like consistency. If you are trying to cut down on fat but still want to enjoy a nice curry, this recipe is perfect for you.

AtThe Beet, we're alwaysuncovering plant-based foods that have health benefits and are emerging foods to supporta healthy heart, strong immune system, due to their high levels of essential vitamins, and nutrients.

Drinking hot water with lemon in the morning is beneficial for digestive health and immunity, and even helps spark weight loss. New research shows that this habit can help flush out the digestive system, jumpstart metabolism, and give your body a dose of immunity-boosting vitamin C first thing in the morning.

Previously, wespotlightedsoursop, a tropical fruit that helps people get bettersleep, lower inflammation, fight infection andhas thepotential toone day treat cancer cells, according to emerging studies.

Sea buckthorn, a berry native to central Asia and Europe that boosts immunity, clears skin, and fights cancer according to serval studies.If you have a food that you're curious to know more about, contact us and we will break down the health benefits.

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To Help You Lose Weight and Boost Immunity Just Add Ginger - The Beet

Losing weight in a sustainable way means making lifestyle changes that you can stick to. Dramatic diet restrictions and changes to your exercise routine do not work for long, and usually leave you feeling even worse.

Instead, try incorporating simple lifestyle changes into your routine that you will actually be able to do on a regular basis.Here are 4 ways to get started:

100+ Gift Ideas For Everyone On Your Holiday List

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When it comes to weight loss, you might have heard that you should be skipping breakfast, but that couldn't be further from the truth. For tangible and sustainable weight loss, it's crucial that you start your day with a high-protein breakfast that will keep you full.

A good breakfast can help jumpstart your metabolism first thing in the morning and can keep your appetite satisfied until it's time to eat again.

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It might be hard to believe, but your sleep routine can have an impact on your weight.

According to Psychology Today, "When you sleep less than 6 hours a night, your body produces a 'hunger hormone' ghrelin, which stimulates your appetite and causes you to crave carbohydrate-rich and fatty foods...When you get enough sleep, your body produces a satiety hormone, leptin, which naturally curbs your appetite."

With that in mind, if you are hoping to lose weight, it's a good idea to start thinking about your sleep schedule and make the necessary adjustments.

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Getting in your steps everyday is a great way to keep your body moving, even if you are working on the computer all day. Taking breaks to go for a walk outside, pacing while on the phone, and staying active are all important aspects to breaking up a more sedentary lifestyle.

Plus, walking can help regulate your blood sugar. Dr. Robert Zembroski, DC, DACNB, MS tells Bustle, "Data out of Diabetes Care revealed that a 15 minute walk after eating a meal significantly improves blood sugar."

It can also help improve digestion and help keep your cardiovascular system running properly.

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Finding an accountability partner--whether at home or online--can be a huge component to successful weight loss.

First, decide what you want to be held accountable for: weekly workouts? cutting junk food? eating more whole foods? drinking the right amount of water? Then, find someone you trust who will help hold you to that; it's even better if have things they want you to be held accountable for too.

This can help you stay on track, but it can also help you make your goals more reasonable when you know someone will be supporting you through them.

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4 Simple Lifestyle Changes You Can Make To Lose Weight By The Holidays - SheFinds

How much would the government have to pay you to take the Covid-19 vaccine?

For most of us, its a silly question. Recent polls show that around 60% of Americans plan to get vaccinated as soon as possible and need no monetary incentive to do so. The problem is that a 60% vaccination rate may not do the trick. Dr. Anthony Fauci said this week that to keep the virus from finding new hosts, social distancing should continue until 75% to 80% of the population is vaccinated.

With several vaccines on the verge of being approved, talk has understandably turned to distribution. Who should be at the head of the line, health-care workers or elderly residents of long-term-care facilities? Do we give it first to the people most likely to die from Covid or to the people most likely to spread it? At some point, these questions will have to be addressed, but they are all secondary to whether we can get enough people vaccinated.

At this point, we still dont even know how well the vaccines will work. We know how they fared in clinical trials, but previous vaccines have proven to be less effective outside clinical settings. People who enroll in clinical trials tend, among other things, to be healthier than the public at large and easier for doctors to observe. But assuming that the vaccines are effective, how do you convince enough people to get inoculated at a time when public trust in government institutions is at historic lows?

One way to go is using carrots instead of sticks. Telling people they cant fly or send their kids to school may work in some cases, but theres evidence that paying people to get vaccinated might be more effective. In a typical year, less than half of American adults bother to get flu shots. But a 2015 study conducted by economists at Swarthmore College found that offering people a $30 reward was enough to increase vaccination rates by 12 percentage points.

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The Best Herd Immunity Money Can Buy - The Wall Street Journal

7 December 2020

Professor Michael Gleeson, a world authority on exercise, metabolism and nutrition - and author of new weight loss book, The Pick n Mix Diet tells us what we need to know ...

The Pick 'n Mix Diet

Often around this time of year people tend to overindulge a little in food and drink and with COVID-19 lockdowns, some of us have also been getting less exercise, a combination that also leads to weight gain. And that is something that is associated with poor health outcomes if we do get infected with COVID-19.

The usual solution to weight gain is to go on a diet but many people find it difficult to stick to more than a few weeks because most diets restrict food choices and it is easy to get fed up (pardon the pun) with eating the same limited food items. If you go on a keto diet you start to miss your carbs and if you go on a zero fat diet you miss many other items that you normally like to eat. And another downside is that because of their restrictions these sorts of extreme or fad diets are not good for your health because you can develop micronutrient deficiencies.

But there is a solution: dont stick to just one boring diet but change your diet every week.

That is where the The Pick n Mix Diet comes in and now is the time for you to take up this new revolution in dieting: Use multiple diets and add some easy physical activities to burn off that excess fat. By changing the diet weekly you don't get bored with it, you have fewer food cravings and are more likely to stick to your weight loss plan. Also, this approach ensures that your diet is more varied and healthier than any single diet plan.

The great thing about the diet part of my weight loss plan is that it does not require sticking with the same boring diet for week after week. So you can wave goodbye to food cravings.

In my book I describe a novel and effective weight loss plan that anyone who is mobile can do. The diet uses sensible, varied, non-extreme dieting (i.e., no fad diets) combined with enjoyable and exhilarating (but not exhausting) exercise that should see you lose around 10 kilograms (22 pounds) in 10 weeks. The great thing about the diet part of my weight loss plan is that it does not require sticking with the same boring diet for week after week. I utilize a variety of different, but equally effective diets that can be changed on a weekly basis. And none of the exercises I recommend should leave anyone with aching muscles or feeling sick or tired. I have also devoted a chapter to describing meal ideas and recipes so you dont need to learn about how the diets work (although that is all explained in the book); you can just follow the weekly meal plans. You can also pick and mix your diets and activities to personalize your weight loss plan to suit your own preferences.

Numerous scientific studies show that the most effective, safe and healthy way to lose excess weight is to both eat less and exercise more. There is no need for fad diets, fad exercise regimens or fatiguing high intensity or interval exercise. Just light or moderate intensity aerobic exercise which is scientifically proven to maximize fat burning. This means you can combine multi-diet dieting with some easy physical activities to burn more fat without hunger, food cravings or tiredness. You can lose weight and get fitter and healthier at the same time.

The Pick n Mix Diet published by Meyer & Meyer is released this week and is available from all good book stores and online retailers, along with Professor Gleesons other books, Eat, Move, Sleep, Repeat - a healthy lifestyle guidebook, and Beating Type 2 Diabetes. Further information can be found at http://www.meyer-meyer-sport.co.uk

If youre living with multiple sclerosis (MS), you may have wondered about eating a healthier diet. Theres so much (often contradictory) information out there, though, it can be confusing to know where to start. Some foods can trigger inflammation, while others may be beneficial. So, heres a quick review of common dietary approaches for MS... to read more clickHERE

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Here's how to lose weight without sticking to one boring diet by Professor Michael Gleeson - FemaleFirst.co.uk

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What Is Reverse Dieting? A Nutritionist Explains | Deep Dives| Health - FOX10 News

From Prevention

Rebel Wilson, 40, opened up about how she shed 60 pounds after declaring 2020 her Year of Health.

The Pitch Perfect actress credited walking as her favorite safe and free exercise.

Wilson also worked with personal trainers, focusing on HIIT and mobility workouts.

Just days after revealing that she has officially reached her goal weight one month early, Rebel Wilson got candid with her fans on Instagram, answering their questions and sharing the tips that helped her lose 60 pounds this year.

In a new video shared to IGTV, the 40-year-old actress opened up about the methods that truly made 2020 her self-proclaimed Year of Health.

Her biggest tip? Start walking!

I know Im in a lucky position, I do have access to really amazing personal trainers. But I want you guys to know that the majority of exercise Ive done this year has just been me going out for a walk, she said. No matter where she was in the world, Wilson said she made sure to get her walks in. That is free, you can do it, its safe.

Walking is the best way for mefor my body typeto metabolize fat, she added. On the physical side, my biggest tip, guys, is get out there and walk. If you can do an hour, thats what I like to do, when I go walking, and it is the best. Just get your body moving.

To keep moving, Wilson loves to listen to a motivational podcast while walking or hiking. I never thought I would like hikingwalking uphill. Who would have thought that would be a fun activity? But freak, its good! she said. Get out in nature. Get air into your lungs. I really, really love it, so I do it now all the time.

Throughout the year, Wilson has been keeping fans updated about her progress on Instagram. In addition to hiking, the actress would wake up early for morning sprint workouts, and she also enlisted the help of personal trainers Gunnar Peterson and Jono Castano Acero.

Acero opened up to Today about Wilsons fitness routine, which included high intensity interval training (HIIT), mobility moves, resistance training, and recovery days. He explained that her typical week would look something like this:

Story continues

In her Instagram video, Wilson opened up about what motivated her to kick off her weight loss journey in the first place. The actress admitted she suffers from emotional eating, which she still struggles with from time to time.

The old patterns still come up, she said. Maybe not every day. But if Im worried or anxious or whatever, it still comes up for me. Its not something thats just going to disappear, its just something I have to manage now moving forward. (She reportedly started following the Mayr Method to boost her nutrition goals.)

Its just about how you manage it and what you can do to try to replace your unhealthy habits with healthy ones, she said.

Its clear shes been committed to her health this past year. She's been working hard, and it shows. Go, Rebel!

Go here to join Prevention Premium (our best value, all-access plan), subscribe to the magazine, or get digital-only access.

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Rebel Wilson Says This Free, Safe Exercise Helped Her Lose 60 Pounds in a Year - Yahoo Lifestyle

DetailsCategory: Proteins and PeptidesPublished on Sunday, 06 December 2020 11:21Hits: 761

Saxenda (liraglutide) injection 3 mg becomes the first FDA-approved therapy to treat obesity in adolescents in more than a decade

PLAINSBORO, NJ, USA I December 4, 2020 I Novo Nordisk today announced that the U.S. Food and Drug Administration (FDA) approved an updated label for Saxenda(liraglutide) injection 3 mg for use in the treatment of obesity in adolescents (1217 years) with a body weight above 60 kg and an initial body mass index (BMI) corresponding to 30 kg/m2 or greater for adults, as an adjunct to reduced-calorie meals and increased physical activity. Saxenda was approved in 2014 for chronic weight management in adults with a BMI 30 kg/m2, or 27 kg/m2 with at least one weight-related comorbidity, as an adjunct to a reduced calorie meal plan and increased physical activity.1

Over the last 20 years, the global prevalence of children and adolescents with excess weight has doubled from 1 in 10 to 1 in 5.2Research also shows that when both parents have excess weight, 80% of their children will have obesity.3However, current treatment options for this population are limited, highlighting a considerable and growing need for additional treatment strategies.4

"New options to treat adolescents who live with obesity can bring much-needed hope to families and help address this growing epidemic," said Dr. Aaron Kelly, Professor of Pediatrics and co-director of the Center for Pediatric Obesity Medicine at the University of Minnesota. "With up to 90 percent of adolescents with obesity likely to have it as adults and thus at increased risk for developing weight-related complications, it's important to address weight care and offer support early on.3,5I'm encouraged that healthcare providers now have another tool in developing a personalized, complete care plan to help adolescents lose weight and keep it off."

The safety and efficacy of Saxenda as a treatment for adolescents with obesity is supported by data from a phase 3a trial published earlier this year in the New England Journal of Medicine. The 56-week clinical trial investigated the effects of Saxenda compared to placebo for weight management in 251 patients aged 12-17 living with obesity as an adjunct to lifestyle therapy, defined as counselling in healthy nutrition and physical activity for weight loss. In the trial, the primary endpoint was change from baseline in Body Mass Index (BMI) Standard Deviation Score (SDS) at week 56.6

The data demonstrated a significant reduction in BMI-SDS, as well as reductions in BMI, mean body weight, and other weight-related endpoints vs. placebo in adolescents with obesity when using Saxenda as an adjunct to lifestyle therapy. Adverse events seen in an adolescent population were similar to those observed in adults. The most common adverse reactions were gastrointestinal events, including nausea, vomiting and diarrhea.6

"The rise in adolescent obesity is contributing to a public health crisis, and it poses a real challenge for healthcare professionals due to the limited treatment options available," said Mads Krogsgaard Thomsen, executive vice president and chief scientific officer of Novo Nordisk. "We are proud to be able to offer a new treatment option for adolescents with obesity and their families in the US, as the FDA approval marks another significant milestone for Saxenda."

What is Saxenda?

Saxenda (liraglutide) injection 3 mg is an injectable prescription medicine used for adults with excess weight (BMI 27) who also have weight-related medical problems or obesity (BMI 30), and children aged 12-17 years with a body weight above 132 pounds (60 kg) and obesity to help them lose weight and keep the weight off. Saxenda should be used with a reduced calorie diet and increased physical activity.

Important Safety Information

Do not share your Saxenda pen with others even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.

What is the most important information I should know about Saxenda?Serious side effects may happen in people who take Saxenda, including:

Possible thyroid tumors, including cancer. Tell your health care professional if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats and mice, Saxenda and medicines that work like Saxenda caused thyroid tumors, including thyroid cancer. It is not known if Saxenda will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people.

Do not use Saxenda if you or any of your family have ever had MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN2).

Who should not use Saxenda?Do not use Saxenda if:

Before taking Saxenda, tell your health care provider about all of your medical conditions, including if you:

Tell your health care provider about all the medicines you take, including prescription, over-the-counter medicines, vitamins, and herbal supplements. Saxenda slows stomach emptying and can affect medicines that need to pass through the stomach quickly. Saxenda may affect the way some medicines work and some other medicines may affect the way Saxenda works. Tell your health care provider if you take diabetes medicines, especially insulin and sulfonylurea medicines.

How should I use Saxenda?

What are the possible side effects of Saxenda?Saxenda may cause serious side effects, including:

The most common side effects of Saxenda in adults include nausea, diarrhea, constipation, vomiting, injection site reaction, low blood sugar (hypoglycemia), headache, tiredness (fatigue), dizziness, stomach pain, and change in enzyme (lipase) levels in your blood. Additional common side effects in children are fever and gastroenteritis.

Please see Prescribing Information and Medication Guide for Saxenda at http://www.novo-pi.com/saxenda.pdf.

About the phase 3 trial (NCT02918279)

The trial investigated the effect of Saxenda (liraglutide 3.0 mg or maximum tolerated dose) compared to placebo for weight management in 251 adolescents (aged 12 to <18 years) living with obesity as an adjunct to lifestyle therapy.6 The trial included a 12-week run-in period of lifestyle therapy, a 56-week treatment period (including dose escalation over 4 to 8 weeks) on Saxenda or placebo and a 26-week follow-up period without Saxenda or placebo.6 All participants received lifestyle therapy beginning with the run-in period and during the 56-week treatment period and 26-week follow-up period.6 The phase 3a trial was a post-marketing requirement of the FDA under the Pediatric Research Equity Act (PREA), which aims to ensure treatments are safe and effective for children and adolescents.7,8

About SaxendaSaxenda (liraglutide) injection 3.0 mg is a once-daily glucagon-like peptide-1 (GLP-1) receptor agonist with 97% similarity to naturally occurring human GLP-1, a hormone that is involved in appetite regulation and food intake.1 Like human GLP-1, Saxenda is believed to work in areas of the brain involved in appetite regulation, including the hypothalamus.1Saxenda for use in adults with obesity was evaluated in the SCALE (Satiety and Clinical Adiposity Liraglutide Evidence) clinical trial program. Since launch in 2015, more than 1.5 million patients have been treated with Saxenda globally.7

Saxenda is already indicated in the US for chronic weight management in adults with a BMI 30 kg/m2, or 27 kg/m2with one or more weight-related comorbidities, as an adjunct to a reduced-calorie meal plan and increased physical activity.1

About obesityObesity is a chronic, progressive and misunderstood disease that requires long-term medical management.9,10 One key misunderstanding is that this is a disease of willpower, when in fact there is underlying biology that prevents people from achieving long-term weight loss.11 Obesity is influenced by a variety of factors, including genetics, appetite signals, behavior and the environment.11 It is a gateway disease and is associated with at least 60 other health conditions.12 The current COVID-19 pandemic has highlighted that obesity also increases the risk for severe illness and hospitalization due to COVID-19.13,14In the United States, more than 42% of adults live with obesity.15

About adolescent obesityAdolescents with obesity are also more likely to develop weight-related diseases, like diabetes and cardiovascular diseases, at a younger age.16Just like other chronic diseases, obesity requires long-term management.9,10 Research shows that when both parents have excess weight, about 80% of their children will have obesity.3 Globally, more than 124 million children and adolescents have obesity.17In the United States, nearly 1 in 5, or about 13.7 million, children and adolescents have obesity.18,19

About Novo Nordisk Novo Nordisk is a global healthcare company that's been making innovative medicines to help people with diabetes lead longer, healthier lives for 95 years. This heritage has given us experience and capabilities that also enable us to help people defeat other serious diseases including obesity, hemophilia and growth disorders. We remain steadfast in our conviction that the formula for lasting success is to stay focused, think long-term and do business in a financially, socially and environmentally responsible way. With U.S. headquarters in New Jersey and production and research facilities in six states, Novo Nordisk employs nearly 6,000 people throughout the country. For more information, visitnovonordisk.us, Facebook, Instagramand Twitter.

References

1US Food and Drug Administration (FDA). Saxenda Prescribing Information. December 2020.

2UNICEF. The state of the world's children 2019. Available at: https://www.unicef.org/media/60806/file/SOWC-2019.pdf. Last accessed: November 2020.

3Lifshitz F. Obesity in Children. J Clin Res Pediatr Endocrinol.2008 Dec; 1(2): 5360

4Cardel M, Jastreboff A, Kelly A. Treatment of Adolescent Obesity in 2020. JAMA. 2019; 322:17071708.

5Gordon-Larsen P, The NS, Adair LS. Longitudinal Trends in Obesity in the United States from Adolescence to the Third Decade of Life. Obesity. 2010; 18 (9): 1801-1804

6Kelly A, Auerbach P, Barrientos-Perez M. A Randomized, Controlled Trial of Liraglutide for Adolescents with Obesity. Available at: https://www.nejm.org/doi/full/10.1056/NEJMoa1916038. NEJM. 2020;DOI: 10.1056/NEJMoa1916038

7Novo Nordisk. Data on File.

8Center for Drug Evaluation and Research. Pediatric Research Equity Act. U.S. Food and Drug Administration. https://www.fda.gov/drugs/development-resources/pediatricresearch-equity-act-prea. Last accessed: November 2020.

9American Medical Association. A.M.A Adopts New Policies on Second Day of Voting at Annual Meeting. Obesity as a Disease. Available at: http://news.cision.com/american-medical-association/r/ama-adopts-new-policies-on-second-day-of-voting-at-annual-meeting,c9430649. Last accessed: November 2020.

10Bray GA, Kim KK, Wilding JPH. World Obesity Federation. Obesity: a chronic relapsing progressive disease process. A position statement of the World Obesity Federation. ObesRev. 2017;18(7):715-723. doi:10.1111/obr.12551.

11Wright SM, Aronne LJ. Causes of obesity. Abdom Imaging. 2012;37(5):730-732.

12Bays HE, McCarthy W, Christensen S, et al. Obesity Algorithm, presented by the Obesity Medicine Association. Available at: https://obesitymedicine.org/obesity-algorithm/. Last Accessed: November 2020.

13Finer N, Garnett SP and Bruun JM. COVID-19 and obesity. Clin Obes. 2020; 10:e12365.

14Ryan DH, Ravussin E and Heymsfield S. COVID 19 and the Patient with Obesity - The Editors Speak Out. Obesity. 2020; 28:847.

15Centers for Disease Control and Prevention. Adult Obesity Facts. Available at: https://www.cdc.gov/obesity/data/adult.html. Updated June 29, 2020. Last accessed: November 2020.

16World Health Organization. Childhood overweight and obesity. Available at: https://www.who.int/dietphysicalactivity/childhood/en/. Last accessed: November 2020.

17World Health Organization. Obesity and overweight. Available at: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Last accessed: November 2020.

18Centers for Disease Control and Prevention. Childhood Overweight and Obesity. Available at: https://www.cdc.gov/obesity/childhood/index.html. Updated September 11, 2018. Last accessed: November 2020.

19Centers for Disease Control and Prevention. Childhood Obesity Facts. Available at: https://www.cdc.gov/obesity/data/childhood.html. Updated June 24, 2019. Last accessed: November 2020.

SOURCE: Novo Nordisk

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FDA approves Saxenda for the treatment of obesity in adolescents aged 1217 | Proteins and Peptides | News Channels - PipelineReview.com

Most people realise the importance of keeping their weight in check. The only problem is that losing weight is incredibly challenging and a lot of people end up not getting the results they envisioned when they started their weight loss journeys. Losing weight requires a careful approach, and with so much advice on the internet and elsewhere, it can be difficult to choose the right and most effective weight loss approach. When choosing a weight loss approach, there are some things you ought to consider to find one that helps you lose weight and keep your weight in check.

There is no one weight-loss programme that will fit everybody, and this is why it is so important to choose one that is tailored for you. However, you can find one that works for you if you consider your lifestyle and weight-loss goals. Some of the things you should consider include diets you have tried in the past, the structure of the weight loss programme, your budget, and other considerations such as health conditions and allergies.

You might want to have a closer look at the diets you have tried in the past to see what you liked or disliked about them. You should also try to see if they worked as intended and explore the reasons why they did not yield the results you wanted.

The structure of your weight loss will include whether you will be going on this journey alone or if you will require some support. If you do, will you require in-person support or online support?

Choosing a dieting or weight loss programme that is too expensive might make it harder to stick to it in the long term. Try to find out what meals and supplements you might have to buy, as well as any gym membership fees and meetings you might have to attend to see if the cost is not only worth it for you, but sustainable in the long term.

How fast you want to lose weight will largely determine the type of weight loss programme you choose and whether you want to incorporate a diet into your approach. While you might want to start exercising immediately, as that is one of the best ways to lose weight, you might not be able to do so immediately due to your weight. The solution is to rapidly lose a bit of weight before you start working out. This is where dieting comes in.

There are lots of diets you can choose from. If you have a BMI of 29 or less, you can choose a conservative approach. However, if you have a BMI of over 30, you might want to consider a low-calorie diet. These diets limit the number of calories you consume per day so your body utilises more calories than you consume, and this is how you lose weight rapidly.

The Cambridge weight plan is one that a lot of people gravitate towards, but better approaches have come along that solve some of the challenges of being on this diet. Some of these challenges include blood sugar level spikes due to consuming fewer meals and spacing them out too far. Also, there are weight loss plans like Shake That Weight that contain fewer calories per meal compared to the Cambridge weight plan. Because of this, they encourage you to eat more regularly, which helps eliminate hunger pangs and manage blood sugar levels between meals.

As you can see from this Cambridge Weight Plan Comparison, choosing this plan also requires that you sign up for regular weigh-ins, which might be discouraging, especially if you do not see the results you want immediately. The Cambridge Weight Plan comparison from Shake That Weight plan can help you make the transition to a healthier plan. Their programme includes complete meal replacement shakes and bars that contain very few calories. They also ensure their meal replacements have the right amounts of minerals and vitamins so that your nutrition needs are met when on their low-calorie dieting plan.

Rapid weight loss, as discussed above, might not be right for you, and you might therefore want to choose a different path. One of the most important things to think about when choosing a plan that you can live on is the plans flexibility.

A flexible plan allows you to incorporate foods from different food groups and does not exclude certain foods. A healthy plan will encourage you to have a healthy mix of whole grain, fruits, vegetables, lean proteins, low-fat dairy products, and seeds. Although a flexible plan might allow some indulgence, it should also be structured in such a way as to limit your alcohol intake, sugary drinks, and high-sugar sweets.

The plan you choose should also be balanced. This means that it should include adequate calories and nutrients for your daily needs. In this way, it should not encourage you to only eat certain foods exclusively, such as meat in some types of diets, or eliminating whole food groups such as carbohydrates.

Lastly, the plan you choose should encourage some physical activity. Exercising while keeping your caloric intake in check will go a long way in helping you lose weight. It also affords you some additional benefits including helping you sleep better, helping eliminate toxins released during weight loss, and helping you build muscle mass that can help in weight loss.

Although many people do not consider it necessary to involve their physician in their weight loss programme, it can be essential in some cases. One of these cases is where you need to lose weight due to health conditions such as diabetes, high blood pressure, and high cholesterol. In this case, your doctor will be able to help you tailor your diet and workout routine so you can lose weight rapidly, get things under control, and come up with a long-term solution to keeping your weight in check.

Your doctor will help you learn how to exercise safely as well as manage any pain you might experience as you start exercising. Additionally, your doctor will review any medical issues you might have or medications you are taking to ensure any diets you go on do not affect or are not affected by these conditions or medications.

Your doctor might also refer you to a dietician or nutritionist if they think that is what you need before you start your weight loss journey.

You should choose a weight loss programme that focuses on keeping your weight in check in the long term. Many people focus on losing weight immediately and do not realise that they also need to change their lifestyles after losing weight. While it is good to have a plan that helps you hit certain weight loss goals immediately, it is important that the programme also focuses on helping you make better lifestyle choices after the initial rapid weight loss period ends. This can include helping you enjoy healthy foods even while dieting so that you can continue on this path, or giving you the tools to help you avoid going back to previous eating habits.

Losing weight is a highly personal journey, and this is why it is so important that everyone who wants to lose weight chooses a plan that works for them.

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Important Things to Consider When Choosing a Weight Loss Plan - ABCmoney.co.uk

To overcome a weight loss plateau, decrease your calories or increase your activity level. Getty

If you aren't losing weight while following a healthy plan, it might be because you're not getting enough sleep, not drinking enough water, or not exercising enough.

To get back on track with your weight loss goals, you should also make sure to cut back on alcohol, reduce your calories, and try to relieve stress.

If you are still not losing weight, check in with your doctor, as it may be due to an underlying medical condition or certain medications you are taking.

Visit Insider's Health Reference library for more advice.

Countless guides exist on how to lose weight, which makes it hard to figure out what approach is right for you. However, before you start trying to lose weight, it's important to consider whether or not you shouldlose weight - and if so, how much is healthy.

Therefore, you should consult with your doctor before beginning any weight loss program, as they can help you decide if losing weight is right for you. They can also help you determine the safest way to lose weight based on your own unique health needs. While shedding pounds may help decrease your risk for heart disease and diabetes, losing too much weight can also come with its own set of health conditions such as fatigue, weak bones, and fertility problems.

Once you're in a healthy weight-loss plan, there's always the risk of not losing as much weight as you like. Adjusting your diet or activity level might be all you need to do to see results. But sometimes, your efforts can fall flat. Here are some common reasons why you may be struggling to lose weight:

To lose weight, you need to take in fewer calories than you burn. This is called a calorie deficit. If you're in a calorie surplus, your body stores those extra calories as fat.

To ensure you're consuming the right amount of calories, monitor your caloric intake, as well as physical activity. You can do this by keeping track of the calories you're eating and burning through fitness apps or in a food log. A large 2006 study found that those who planned meals and tracked calories successfully lost weight and maintained weight loss more than those who did not.

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Alcohol is energy dense, meaning it contains a high amount of calories per volume, says Ariana Chao, CRNP, the medical director of the Center for Weight and Eating Disorders at the University of Pennsylvania's Perelman School of Medicine.

For reference, alcohol has about seven calories per gram, while a carbohydrate has four calories per gram. Alcohol can also reduce inhibitions about eating, making you more likely to choose high-calorie foods if you're drinking, Chao says.

A large 2018 study of overweight and obese people with type 2 diabetes found that people who drank heavily lost less weight over a four-year period than those who did not drink and decreasing alcohol consumption may improve weight management in people with diabetes.

Mixed drinks are especially high in calories due to the sugar-laden fruit juices and other ingredients often mixed in. For example, one pina colada can contain 526 calories. Therefore, if you're trying to lose weight, it's important to limit alcohol intake to stay within your calorie goals, Chao says.

Drinking water can help you lose weight by boosting your metabolism and suppressing your appetite, thus making you feel fuller.

A small 2007 study found that drinking 500 mL (two cups) of water increased energy expenditure by 24% in overweight or obese individuals. Additionally, a small 2015 study of obese people compared participants who drank two cups of water before meals with those who did not. It found those who drank water lost an average of almost three more pounds.

If you usually drink sugary beverages, replace them with water. This will not only keep you more hydrated, but you will also no longer be consuming those calories from sugar, Chao says.

Insufficient sleep can also make it difficult to lose weight, according to a small 2010 study of overweight adults. All participants ate a reduced-calorie diet, and those who slept 8.5 hours lost an average of two pounds more than those who slept 5.5 hours.

Also, a 2008 review found that sleep deprivation can harm metabolism - the process your body uses to convert calories into energy. It found less sleep disrupts hormones that regulate appetite, possibly making people hungrier.

"If people are sleepy and fatigued, they're more likely to choose foods that are more energy dense," such as high-sugar or high-carbohydrate foods like ice cream and pizza, Chao says. And if people are awake late at night, "they might be more likely to reach for a snack or have something extra to eat," she says.

Stress makes it difficult to lose weight because it affects your metabolism. A 2011 study of obese adults found that people with lower stress levels lost more weight.

"Some of my work has shown that when people are stressed, they're more likely to choose energy-dense foods, compared to lower energy-dense foods, to help cope," Chao says. Also, if you're stressed, you may be less likely to find time to exercise or cook, instead, relying on fast food.

To reduce stress, try exercising. This will also help you burn more calories.

If you're sitting all day, you're not expending as much energy as you would if you were moving around, and "that in itself can contribute to not losing as much weight," Chao says.

There's a difference between being sedentary and being physically inactive. For example, if you sit all day for work, but also meet the recommended 150 minutes of weekly physical activity, you're still considered sedentary.

Obese people are more likely to be seated for 2.5 more hours per day than their normal-weight counterparts, according to a 2006 study. The study suggests spending 2.5 more hours - separate from exercise - standing and walking per day to help fight obesity. This could include holding work meetings or watching TV while standing.

If your weight loss has stalled for no apparent reason, you've hit a plateau. As you lose weight, your metabolism starts to decline, so you burn fewer calories than you did initially.

A small 2014 study found that people's failure to adhere to their reduced-calorie diet caused them to hit a weight loss plateau earlier. "What happens is it's harder and harder to maintain that low caloric intake - an intake that is less than you're expending - and the hunger mechanisms kick in stronger and stronger," Dale Schoeller, professor emeritus of nutritional sciences at the University of Wisconsin College of Agricultural and Life Sciences.

People often hit a weight loss plateau at around six to 12 months, Chao says. "Usually, what I recommend people start with is to self-monitor again, to track their food intake as well as their physical activity, and to track it pretty closely." That way, they can make modifications, she says.

To get past a plateau, you may need to increase your exercise. "We know that having higher amounts of exercise is really important for keeping weight off long term," Chao says.

If you need help losing weight, you can see a doctor or dietitian who specializes in weight loss. They can help you find a plan that works for you. "A lot of long-term weight loss is really about being able to adhere to something that they'll be able to stick with for their whole lifetime," Chao says.

Some underlying medical conditions can make weight loss more difficult, such as hypothyroidism - when your thyroid isn't functioning properly. Certain medications, such as some steroids and antidepressants, can also make weight loss challenging, Chao says. Your doctor can treat these conditions or change medications.

Sometimes, you're taking the right steps to lose weight, but you might not realize how sleep or stress are preventing your progress. By paying attention to your daily activities - what you're eating and drinking, how much you're moving, your feelings, and your sleep schedule - you can get back on track for weight loss.

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