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A medical treatment given to children in the UK may have led to some developing Alzheimers disease decades later, new research out Monday suggests. The study presents evidence that at least five people contracted the neurodegenerative disorder from having received human growth hormones contaminated with rogue amyloid beta protein. The authors point out that Alzheimers cannot be caught person-to-person through conventional means, however, and this specific infection risk no longer exists today.

Alex Winter on Innovative Horror Movies

Starting in the 1950s, scientists learned how to extract human growth hormone (HGH) from the pituitary glands of cadavers. Unfortunately, the method only provided minute amounts of hormone at a time, which limited the supply of HGH available for medical and research purposes. As a result, its distribution was meticulously handled, and it was typically only given to treat the most severe growth-related conditions in children.

This remained the status quo for the next 30 years, with more than 20,000 children worldwide having received this form of cadaver-derived HGH. But in the mid-1980s, health officials in the U.S. and elsewhere began to get unusual reports of people coming down with Creutzfeldt-Jakob disease (CJD), a rare but universally fatal neurodegenerative disease. These cases were happening in much younger people than typically seen with CJD, and it was soon discovered those affected shared a history of past HGH treatment. Within months of this discovery, the U.S. and other countries shut down their cadaver HGH programs.

These cases, as it turned out, were caused by HGH seeded with a persons misfolded prionsmutinous proteins that eat away at the brain by gradually transforming normal prions into their misfolded form. It can take years to decades before the symptoms of a prion disease appear, explaining why it took so long for the connection to be discovered. As of today, there have been around 220 cases of Creutzfeldt-Jakob disease linked to cadaver-derived HGH, with some showing up to 40 years later.

Researchers at the University of College London have continued to keep track of potential cases of illness tied to HGH. And over time, theyve come across patients who seem to have avoided CJD but have developed other neurological conditions, including Alzheimers disease. In a paper published in Nature Medicine Monday, they argue that these cases represent a rare but real form of transmissible Alzheimers.

The paper details eight patients who visited the UCLs National Prion Clinic. Five of them appear to have developed early onset Alzheimers, with a sixth having mild cognitive impairment. But none of the patients seemed to have known genetic mutations that cause Alzheimers to happen at a younger age or other shared factors besides a past history of HGH treatment.

Alzheimers is caused by the build-up of two misfolded proteins in the brain, amyloid beta and tau, with amyloid beta seen as the driving force of the two. The teams past research has found amyloid beta inside the brains of people who died from HGH-caused Creutzfeldt-Jakob disease, as well as inside samples of preserved HGH. And in the lab, theyve been able to successfully cause mice to develop Alzheimers-like illness after exposing them to these contaminated samples.

Put all the pieces together, the study authors say, and its enough to show that Alzheimers disease should now be recognized as a potentially transmissible disorder.

The teams work is the latest to suggest that Alzheimers and other neurodegenerative conditions have a lot in common with prion diseases like CJD (some scientists have even argued that they effectively are prion diseases). Prion diseases are usually inherited or occur spontaneously, for instance, but have rarely been transmitted through contaminated beef or the ritualistic cannibalism of human brains, in addition to HGH treatments. At the same time, people shouldnt be worried about catching Alzheimers or prion diseases like they would a typical infectious germ, like a virus. And scientists eventually learned how to synthesize HGH in the lab that carries no risk of prion or amyloid contamination. This version was given regulatory approval soon after the cadaver programs were shut down.

It is important to stress that the circumstances through which we believe these individuals tragically developed Alzheimers are highly unusual, and to reinforce that there is no risk that the disease can be spread between individuals or in routine medical care, said study author Jonathan Schott, a UCL neurologist and chief medical officer at Alzheimers Research UK, in a statement from the university. These findings do, however, provide potentially valuable insights into disease mechanisms, and pave the way for further research which we hope will further our understanding of the causes of more typical, late onset Alzheimers disease.

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Scientists Find Evidence Alzheimer's Can Be Transmissible - Gizmodo

Florida, a state blessed with incredibly beautiful beaches and inviting weather, is not just a popular tourist destination. It's also home to a growing trend in the field of healthcareHuman Growth Hormone (HGH) therapy. In the Sunshine State, many individuals are turning to HGH therapy not only for its well-known anti-aging benefits but also for its remarkable ability to strengthen bones and joints. This article explores the role of human growth hormone therapy Florida in improving bone and joint health and how it's making a difference in the lives of many Floridians.

Understanding HGH Therapy

Human Growth Hormone (HGH) is a hormone that your body makes on its own, thanks to a special gland in the brain called the pituitary gland. This hormone is really important because it helps the body grow, repair itself, and stay healthy. But as you get older, the body makes less of this hormone. That can cause problems like weaker bones and joints.

The Impact of Aging on Bone and Joint Health

Florida, with its sizable senior population, faces significant challenges related to bone and joint health. Aging is often accompanied by conditions like osteoporosis and osteoarthritis, resulting in fragile bones and painful joints. These issues can affect mobility, independence, and overall quality of life.

HGH Therapy's Role in Strengthening Bones

One of the most promising aspects of HGH therapy is its ability to increase bone density. This benefits older individuals in Florida, where osteoporosis is a prevalent concern. HGH therapy stimulates bone growth and mineralization, making bones stronger and less susceptible to fractures.

HGH therapy can help in the healing of bone injuries and fractures. In Florida's active lifestyle, where accidents can happen, the ability to recover from bone injuries more rapidly is a significant advantage.

Enhancing Joint Health with HGH Therapy

Florida's warm climate encourages an active lifestyle, but joint problems can hinder this enjoyment. HGH therapy can also play a pivotal role in improving joint health. It stimulates collagen production, a vital component of cartilage that cushions and protects joints.

As collagen levels increase, joints become more resilient, reducing the risk of conditions like osteoarthritis. Many Floridians have found that HGH therapy allows them to continue enjoying outdoor activities like golf, tennis, and swimming well into their golden years.

Individualized Treatment Plans in Florida

One of the advantages of pursuing HGH therapy in Florida is the availability of specialized clinics that offer individualized treatment plans. These plans meet each patient's unique needs, taking into account their age, health status, and lifestyle.

Before beginning HGH therapy, patients typically undergo a comprehensive evaluation, including blood tests and a medical history review. This helps healthcare providers in Florida determine the appropriate dosage and treatment duration, ensuring optimal results while minimizing potential risks.

Safety and Monitoring

Patient safety is a top priority in Florida's HGH therapy clinics. Regular monitoring ensures the therapy is effective and safe. During the course of treatment, patients undergo periodic check-ups, including blood tests, to assess hormone levels and overall health.

Clinicians in Florida work closely with patients to monitor their progress and make necessary adjustments to their treatment plans. This personalized approach helps patients receive the maximum benefits of HGH therapy while minimizing any potential side effects.

Human growth hormone therapy in Florida is making a significant difference in the lives of those seeking to strengthen their bones and joints. With its ability to increase bone density, promote collagen production, and enhance joint health, this therapy is helping individuals maintain their mobility and independence well into their later years.

Continued here:
HGH Therapy in Florida: Strengthening Bones and Joints - Yes! Weekly

The worldwide human growth hormone treatment and drugs market including human growth hormone is anticipated to reach a value of US$ 3.55 billion by the end of 2022. The market is anticipated to expand at a compound annual growth rate (CAGR) of 3.7% from 2023 to 2033, reaching a market value of around US$ 5.26 billion by that time.

Industry participants investments, the presence of a solid pipeline, extensive R&D efforts, a comprehensive product portfolio, and expanding government initiatives are all projected to drive the demand for human growth hormone treatment & drugs.

Human growth hormone manufacturers are investing in research and development to create a growth hormone with fewer side effects and the potential to be a long-term treatment.

The human growth hormone supplements market is growing due to an increase in disorders connected to growth hormone insufficiency, an increase in the use of ageing hormones, government and private sector efforts to raise awareness of growth hormone deficit, and high productivity. Other reasons such as greater understanding of the treatment process, an increase in the number of health conditions, and an increase in the number of neuropsychiatric cases are expected to boost the human growth hormone treatment & drugs market sizes growth. Human growth hormone supplements market expansion is projected to be driven by the quick growth of new human growth hormone novels.

Get a Sample Copy of the Report: https://www.futuremarketinsights.com/reports/sample/rep-gb-14401

As per the global human growth hormone treatment & drugs market study, the industry is likely to be driven by initiatives taken by various government and private organizations to raise awareness about GH deficiency and human growth hormone treatment.

International Childrens Growth Awareness Day is observed every year by the International Coalition of Organizations Supporting Endocrine Patients (ICOSEP), a nonprofit charitable organization based in the United States, to increase public knowledge regarding the early detection and intervention of human growth hormone problems, particularly in children.

However, the high price of hGH therapies, as well as severe hGH-related side effects, may negatively impact the human growth hormone for sale over the projection period.

Knee, hip, or other joint discomforts; allergic reactions, such as redness, swelling, or hives; and an increase in blood sugar levels are all possible adverse effects of GH hormone therapy, according to UPMC Childrens Hospital of Pittsburgh.

Key Takeaways:

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A healthy product portfolio and extensive Market research investments for the emergence of future growth hormone treatments are projected to propel the sales of human growth hormone treatment & drugs.

Competitive Landscape :

The demand for human growth hormone treatment & drugs is moderately concentrated, with a few key manufacturers owning a large portion of the industry. Furthermore, several active collaborations are underway to generate more effective and long-acting subtypes of human growth hormones.

Key human growth hormone manufacturers include:

Pfizer Inc. began a Phase III research trial in February 2021 to assess the efficacy and security of somatropin in a group of Japanese patients with Prader-Willi Syndrome (PWS).

In October 2020, Erasmus Medical Center, in collaboration with Pfizer, the Foundation for Prader-Willi Research, and the Prader-Willi Fonds, launched a Phase III clinical trial to evaluate the impact of growth hormone treatment (Genotropin) on physical and psychosocial wellbeing in adults with Prader-Willi syndrome who are 30 years or older.

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Key Market Segments Covered in Human Growth Hormone Treatment and Drugs Market Industry :

By Route of Administration:

By Application:

By Distribution Channel:

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Future Market Insights, Inc. (ESOMAR certified, recipient of the Stevie Award, and a member of the Greater New York Chamber of Commerce) offers profound insights into the driving factors that are boosting demand in the market. FMI stands as the leading global provider of market intelligence, advisory services, consulting, and events for the Packaging, Food and Beverage, Consumer Technology, Healthcare, Industrial, and Chemicals markets. With a vast team of over 5000 analysts worldwide, FMI provides global, regional, and local expertise on diverse domains and industry trends across more than 110 countries.

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Human Growth Hormone Treatment and Drugs Market Foresees a ... - PharmiWeb.com

A SUM of RM3,911,853 was raised at a charity dinner and concert to benefit UTAR Hospital in Kampar, Perak.

The fundraising, part of UTAR Hospitals final push to garner donations for its development fund, was in part made possible by the Tiger Sin Chew Chinese Education Charity Concert (TSCCECC) programme.

Over 64 tables were sold and more than 1,000 guests attended the event, which took place at HGH Convention Centre in Sentul, Kuala Lumpur.

(From left) Wu, Yee Yee, Lee, Z Yan, Chiang and Jyin performing on stage.

Universiti Tunku Abdul Rahman (UTAR) president and chief executive officer Prof Datuk Dr Ewe Hong Tat said the money collected from the fundraiser would go towards the hospitals development.

Since construction work began in 2018, we had set a target of collecting RM330mil.

To date, we have reached the RM300mil mark.

Special welcome - Guests greeting the arrival of Dr. Ling (seated in wheelchair) and flanked by Heng at the concert. - Photos: CHAN TAK KONG/The Star

The funds will allow us to provide additional services such as establishing the specialist centre for orthopaedics, internal medicine, paediatrics, obstetrics and gynaecology.

The help of philanthropists, charitable societies and generous donors from the community over the years has allowed the hospital to begin operations, said Prof Ewe.

Freddie and the Catz performing during charity dinner show in benefit of UTAR Hospital at the HGH Convention Centre. - Photos: CHAN TAK KONG/The Star

A non-profit entity, UTAR Hospital offers western as well as traditional and complementary medicine.

Among those who had contributed was the event venue, HGH Convention Centre.

The centres management committee chairman Datuk Eddie Heng said that they had agreed to provide the venue, food and special effects such as stage lighting.

At the fundraiser were (from left) UTAR council members Datuk Lim Si Cheng and Hew Fen Yee, Prof Ewe, Prof Chuah, UTAR Institute of Chinese Studies dean Assoc Prof Dr Chong Siou Wei, Dr Ling, Roland, Koo Cheng and Heng. Photos: CHAN TAK KONG/The Star

He estimated that the package was worth over RM120,000.

We agreed to this because we saw it as a worthy cause.

It is a non-profit hospital which charges nominal fees but offers quality care.

When one is sick, every minute is torture and every second feels like a struggle for survival.

If we can play a part to provide relief to the sick, then why not? said Heng.

The TSCCECC is part of Heineken Malaysia Bhds social impact programme.

Yee Yee captivating her audience.

Since its inception in 1994, it has raised more than RM390mil for 538 schools.

This is the first year the social impact programme has extended its support to a hospital.

Heineken Malaysia managing director Roland Bala said the programmes sustainability was fuelled by the Chinese communitys commitment to education.

In life, there are two things that can make a difference.

One is a deep sense of values. Another is good education.

This is why the Chinese community has achieved so much progress.

No matter their financial background they will never stinge on, much less forgo education for their children, said Roland.

Expressing her delight at the donors generous contributions was the brewers marketing director Willemijn Sneep.

Our initial target was RM3mil but the total collected exceeds our expectations, she said.

For the opening act, dancers, clad in silver sequined bodysuits took to the stage.

This was followed by artists Wu Jia Hui, Yee Yee, Victor Lee, Z Yan, Zac Chi Chiang and Jyin.

Making special appearances were guest singer Chris Cheong, who won the Astro 2020 Classic Golden Melody Singing Competition, and Malaysian Chinese music group Freddie and The Catz.

Attending the event as guests of honour were UTAR chancellor Tun Dr Ling Liong Sik and wife Toh Puan Ena Ling.

Also present were UTAR Hospital board chairman Emeritus Prof Tan Sri Dr Chuah Hean Teik and Sin Chew Media Corporation Bhd executive director Koo Cheng.

Read more here:
RM3.9mil raised in aid of UTAR Hospital - The Star Online

Modified Apr 20, 2023 15:32 GMT

Roger Clemens was a star MLB player and one of the best hitters of all time.

Debbie Clemens, his wife, allegedly received HGH shots in secret without telling him in 2012. Clemens' trainer injected the star's wife with HGH.

The night after getting the shot, Debbie Clemens claimed that she struggled to fall asleep due to circulation issues. She described calling her husband and telling him about the injection. She said that Roger Clemens "wasn't happy with Brian" about it and that she wasn't "old enough yet" in her husband's eyes.

The former pitching ace admitted during his 2012 perjury trial that her husband's former trainer had given her a dose of the human growth hormone.

Roger Clemens was allegedly one of many players who used PEDs in 2006, according to former pitcher Jason Grimsley's federal complaint.

Andy Pettitte, a former New York Yankees pitcher and Clemens' teammate, testified that Clemens acknowledged using the human growth hormone between 1999 and 2000. He later explained that he was referring to his wife's drug use.

The Chicago Tribune reports that Clemens' agent, Randy Hendricks, angrily refuted the allegations and Clemens' use of performance-enhancing drugs in 2006.

Roger Clemens was facing a second trial on federal charges of lying to a U.S. congressional committee following his denial of using PEDs.

The House of Representatives Oversight and Government Reform Committee was investigating drug use in Major League Baseball at the time.

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"I'm not ashamed of taking that shot...I'm embarrassed that it went across the world" - When Roger Clemens' trainer injected star's wife -...

A workout that works twice as hard, so we dont have to? Sign. Us. Up.

We are major fans of efficiency when it comes to fitness, which is why we are totally into Rachael Blumbergs fitness creation, PlateFita fitness class that uses a vibrating plate to burn twice the cals in half the time.

In fact, we love it so much, we hosted a PlateFit workout at Camp Poosh this year.

There is something magical, and yet very scientific, about spending time on vibration. This metaphysical experience and its visceral results are so powerful. It changed the trajectory of my life after just 30 seconds on the plate, and its why I continue sharing vibration with others, Rachael says.

Below, we catch up with her to learn more about the mind, body, and beauty benefits of this high-vibe workout.

What is PlateFit?

We cultivate transformation and whole body wellness through the science of vibration, Rachael tells us. Our signature, 27-minute PlateFit classes support muscle recovery, strengthen and elongate the body, detoxify the system, and help you vibrate higher.

How does it work?

PlateFit classes use medical-grade devices that emit rapid harmonic vibrations to destabilize the body, Rachael says. Your muscles reflexively work harder to keep you stabilized.

The plates move in three directions at once: left to right, front to back, up and down, she says. During our workout classes, muscles contract 30 to 50 times per second! Thats roughly 900 to 1,500 contractions every 30 seconds.

What are the benefits?

BodyToned musclesIncreased strengthImproved enduranceImproved flexibilityBetter balance and coordinationFaster metabolismImproved circulationFat loss

MindDecreased cortisol levelsIncreased serotoninImproved sleep

BeautyIncreased HGH (a hormone that stimulates cell growth and regeneration)Brighter, glowing skinFlushed lymphatic system

Will any vibrating plate work?

In short: no.

There are several vibrating plate machines on the market. but the technology and the way in which the vibration is created is not the same, Rachael says. I choose to work exclusively with PowerPlate machines as they are certified medical devices, backed by years of research and development. PowerPlate also continues to study vibration, which holds so much value as were endlessly learning about the human body.

How long do you need to work out on the plate?

Twenty-seven minutes is all you need, according to Rachael. She recommends four classes a week, plus two of their deep recovery classes.

The content provided in this article is provided for information purposes only and is not a substitute for professional advice and consultation, including professional medical advice and consultation; it is provided with the understanding that Poosh, LLC (Poosh) is not engaged in the provision or rendering of medical advice or services. The opinions and content included in the article are the views of the interviewee only, and Poosh does not endorse or recommend any such content or information, or any product or service mentioned in the article. You understand and agree that Poosh shall not be liable for any claim, loss, or damage arising out of the use of, or reliance upon any content or information in the article.

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This Vibrating Fitness Plate Cuts Your Workout in Half - Poosh

PRESS RELEASE

Published April 19, 2023

An international Achondroplasia business research document studies the key factors affecting the market and various opportunities in the market. Moreover, the report aims to examine the overall size of the market and infer the key trends from it. To inspect the market based on market share, product, and product share. Market instructions provided in this market analysis report are very specific and research-backed. They have been created to help players move in the right direction during their journey to achieve success in the market. Achondroplasia report also evaluates the market on the basis of end-users and applications and focus on the growth rate of each application.

The persuasive Achondroplasia Market research reports will be favorable for new comers/new investors, propose investors and private equity enterprises, analysts and prudent business organizers, suppliers, manufacturers, and distributors, and end-use industries. For getting customization of the report, reach DBMR team via email or phone. If there is any special business requirement or necessity of a point by point of the whole research, dont mind, let us know and get the report as needed. Achondroplasia market report enables clients to enhance business efficiency and focus on other core aspects of operations rather than wasting time in market research and reporting needs.

Data Bridge Market Research analyses a growth rate in the global achondroplasia market in the forecast period 2022-2029. The expected CAGR of global achondroplasia market is tend to be around 36.5% in the mentioned forecast period. The market was valued at USD 68.73 million in 2021, and it would grow upto USD 828.34 million by 2029.

Arachnoiditis is also known as achondroplasia dwarfism, which is the bone growth disorder and the most common form of short-limbed dwarfism. It is largely characterized by short stature and short limbs. The genetic defect can be passed from parent to child. Although, in around 80% of instances, achondroplasia is caused by a spontaneous mutation that originates in the developing embryo. It is of great importance to the healthcare sector and thus is expected to rise high in the forecast period.

Download Sample PDF Copy Of This Report To Understand Structure Of The Complete Report (Including Full TOC, Table & Figures) @ https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-achondroplasia-market

Market Overview

Drivers

The growing prevalence of achondroplasia is projected to drive the market growth during the forecast period. For instance, as per the data published by the European Medicines Agency in June 2021, it is projected that 350 children are born with achondroplasia each year in Europe. This boosts the market growth.

The increasing number of drug approvals and launches by major market players is expected to drive market growth. For example, Ascendis Pharma A/S announced on January 13, 2022, that the European Commission (EC) approved TransCon hGH as a once-weekly subcutaneous injection to treat paediatric patients experiencing growth failure due to insufficient endogenous growth hormone secretion or growth hormone deficiency. TransCon hGH contains Somatropin, which delivers unmodified Somatropin (hGH) to the body in therapeutic quantities.

Global Achondroplasia Market Scope And Market Size

The global achondroplasia market is segmented on the basis of treatment, route of administration, distribution channel and end-user. The growth amongst these segments will help you analyze meagre growth segments in the industries and provide the users with a valuable market overview and market insights to help them make strategic decisions for identifying core market applications.

Treatment

Route of Administration

Hospitals

Distribution Channel

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Key players operating in the global achondroplasia market include:

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https://www.databridgemarketresearch.com/toc/?dbmr=global-achondroplasia-market

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Emerging Trends and Opportunities in the Achondroplasia Market ... - Digital Journal

IGF-1 or Insulin-like Growth Factor 1 supplements and injections are commonly used in the bodybuilding industry. It's an anabolic hormone that stimulates the growth of bones, muscle mass and other tissue cells in the body.

There are questions over its safety and legality in the United States. This article looks at IGF1 supplements and injections and also suggests a legal brand of natural growth hormone that is proving popular and effective with customers worldwide.

CLICK to view price and offers on HGH-X2

HGH-X2 Somatropin is a dietary supplement that releases Human Growth Hormone. In order to increase the amount of HGH (human growth hormone) released into your bloodstream, it is designed to stimulate your body's pituitary gland. With the potent, all-natural HGH supplement for both men and women, you may anticipate high-quality, lean muscle mass development, rapid fat loss, and quicker recovery times.

CLICK to read real reviews oh HGH x2

The pituitary gland in your body naturally produces the anabolic hormone known as human growth hormone booster. It promotes protein synthesis, muscular growth, and increased fat utilization in your body. Age-related declines in HGH levels are inevitable, although research has shown that some amino acids can increase HGH production.

A potent combination of these amino acids is used by HGH-X2 Somatropin to increase your body's HGH synthesis, resulting in quality, lean muscle gains, quick fat loss, and quick recovery times between sessions.

The human growth hormone is turned on by HGH-X2, which also speeds up recovery times by igniting fat storage and muscle building for a larger, leaner physique.

Buy HGH at Crazy Bulk and get free shipping worldwide

IGF-1 is an exogenous hormone that's often used as a bodybuilding muscle growth enhancer. As with similar synthetic hormones that are popular with bodybuilders, such as testosterone and human growth hormone (HGH), IGF-1 is delivered to the body via intramuscular injection.

Although these exogenous hormones are popular bodybuilding drugs, they are not intended to be used in this way. They are FDA-approved treatments for very specific medical conditions. Using them for bodybuilding or sports enhancement is dangerous and illegal and, if pre-competition testing reveals their presence, you will not be able to compete.

Of course, if you only want to grow your muscles and improve your physique, the threat of competition bans will not discourage you from using IGF-1. In all probability, nor will the knowledge you are breaking the law.

However, if you are seriously considering using exogenous IGF-1 supplements for bodybuilding and muscle growth there are some health risks you need to know about.

We are not going to tell you not to inject IGF-1 but nor are we going to encourage you to do it. All human beings are born with the right to free choice.

Instead of getting on a soap box and preaching, we are going to explain what IGF-1 is along with the most important pros and cons.

Also known as somatomedin C, IGF-1 (insulin-like growth factor 1) is a hormone produced in the body.

On a molecular level, it's very similar to insulin and plays a vitally important role in childhood growth. Although adults have lower levels of IGF-1, the hormone continues to provide anabolic benefits throughout life.

Most of the IGF-1 in the human body is produced by the liver. Interestingly, HGH stimulates its production. These two important anabolic hormones have a synergetic nature. HGH aids IGF-1 production. IGF-1 enhances the abilities of HGH.

IGF-1 serves many roles in the body. Supporting muscle growth is one of them. It also aids bone growth and plays a role in regulating blood sugar levels. However, in that regard, it's fair to say insulin does most of the hard work.

Together with HGH, IGF-1 works alongside insulin to regulate muscle mass and help the liver metabolize carbohydrates.

IGF-1 injections are an FDA-approved treatment for children who are not growing because they have low levels of IGF-1 or are suffering from Laron syndrome (growth hormone insensitivity),

Also known as recombinant human insulin-like growth factor-1 (rhIGF-1), synthetic IGF-1 is distributed under several different brand names including Increlex and FK-780.

Unfortunately, although IGF-1 injections have value as a hormone replacement therapy and can benefit children suffering from stunted growth, the treatment can also cause many side effects including dizziness and cardiac murmurs.

Bodybuilders who use IGF-1 to boost muscle growth and muscle gains are unlikely to be low in IGF-1. In all probability, their level of IGF-1 will be correct for their age. By injecting exogenous IGF-1, they are trying to game the system. Although this can result in increases in muscle mass and strength, the risk of side effects is higher as well.

IGF-1 supports improvements in muscle growth by shifting the body into a more anabolic state. It also has the potential to support better workouts and improve muscle gain, cell growth and lean body mass.

Presuming correct strength training and diet, along with sufficient sleep, better workouts will result in superior muscle gains.

IGF-1 increases energy and training capacity by making muscle tissue more sensitive to insulin. This allows the muscles to draw extra glucose from the blood.

However, injecting exogenous IGF-1 to boost muscle growth can interfere with a delicate balance that's generally better left alone.

If bodybuilders are already low in IGF-1, it can cause insulin resistance. This can make workouts more difficult by causing fatigue. Where this is the case, exogenous IGF-1 may be beneficial unless the dose is over the top.

However, when the amount of IGF-1 circulating in the blood is too high, it can cause insulin resistance too. [1]

Injecting IGF-1 in exogenous form increases the risk of this happening. The hormone may improve your workouts or it may hamper them. It's a gamble and there are no guarantees you will win.

Muscle growth (hypertrophy) happens via a process known as protein synthesis that takes amino acids from the blood and uses them to build muscle protein. As you may be aware, this type of building process is a form of anabolism.

IGF-1 plays an important role in the anabolic muscle-building process by binding with IGF-1 receptors and triggering the production of mTOR.

Along with IGF-2, IGF-1 also acts on muscle stem cells to enhance muscle recovery. [2]

Taking things further, IGF-1 inhibits the abilities of FoxO-1 and similar molecules that encourage the breakdown of muscle proteins.

In addition to doing these things, IGF-1 also activates satellite cells that fuse with the muscles to provide myofibrils. Thread-like in nature, these compounds are needed for muscle contraction. [3, 4]

IGF-1 injections can cause many side effects. Although some side effects are mild, others can be dangerous. Even life-threatening.

Known side effects include:

Skin rashes/irritations

Hypoglycemia (low blood sugar)

Muscle weakness

Headaches

Feeling Dizzy

Convulsions

cardiac murmurs

Heart attacks

Anaphylaxis (severe, allergic reaction)

IGF-1 injections also increase the risk of diabetes. That's not at all surprising, bearing in mind the hormone's relationship to insulin and its ability to affect blood sugar.

As if the aforementioned issues were not enough, IGF-1 injections have also been linked to breast and prostate cancers. [5, 6]

Pros

Cons

Illegal to use for bodybuilding

Can cause dangerous side effects

Banned by major sporting associations

In the bodybuilding world, natural supplements are quickly replacing drug and steroid based performance enhancers. IGF 1 supplements can promote the increased production of growth hormones - but so can naturally produced muscle mass building supplements.

HGH-X2 from Crazy Bulk is a hybrid supplement that can release growth hormones into the bloodstream.

A combination of these amino acids is used by HGH-X2 Somatropin to increase your body's HGH synthesis, resulting in quality, lean muscle gains, quick body fat loss, and quick recovery times between sessions. It can also improve the immune system and brain function and reduce the effects of sleep deprivation.

1. The Association Between IGF-I and Insulin Resistance: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308317/

2. Multifaceted Role of Insulin-like Growth Factors and mTOR in Skeletal Muscle: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376019/

3. Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564605/

4. Myofibril: https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/myofibril

5. Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical Diagnostic and in Sports: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913862/

6. Role of Insulin-Like Growth Factors and Their Binding Proteins in Growth Control and Carcinogenesis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144680/

The rest is here:
Best IGF-1 Supplements for Bodybuilding and Muscle Growth ... - Dailyuw

Modified Mar 14, 2023 19:03 GMT

Can LeBron James' return to the court help fuel another big playoff run for the LA Lakers? That is the question on many NBA fans and analysts' minds as of late.

With James currently sidelined, the team has been left to fend for themselves in a stacked Western Conference.

With James' return on the horizon, he posted a cryptic message on his Instagram, which instantly sent NBA fans into a frenzy.

From the sound of things, LeBron James could be looking to return sooner rather than later. If his latest post on Instagram is any sort of hint, the former MVP and the LA Lakers may be ready to take the league by storm.

As the season winds down, the LA Lakers have fought their way into Play-In contention while James has been sidelined. With a 7-3 record in their last ten games, the team will look to ride that momentum into a pivotal clash with the New Orleans Pelicans, who they are currently tied with.

After missing seven straight games, it will be interesting to see when James could potentially return to the lineup. According to head coach Darvin Ham, James is back with the team and everything is going according to plan in regards to his recovery.

Prior to the injury, James continued to put up impressive numbers, breaking Kareem Abdul-Jabbars scoring record before the All-Star break. Unfortunately, for the four-time champion, an injury sustained against the Dallas Mavericks in late-February forced him to the sidelines.

With DAngelo Russell recently returning to the lineup and putting up back-to-back games with 25+ points scored, the return of LeBron would put the Lakers in a great spot. Do you think they will end up making it into the playoffs? Drop your predictions in the comments section below!

Excerpt from:
Loading up on that HGH before the playoffs Fans in frenzy after LeBron James' cryptic IG post - Sportskeeda

Nathan Klima for The Boston Globe The Andover girls basketball team swarms the court at the Tsongas Center to celebrate the culmination of a perfect 26-0 season with a 55-51 victory over Bishop Feehan in the Division 1 girls' state championship.

LOWELL From the moment the Andover girls basketball team lost in last years Division 1 final, they were determined on making it back to the Tsongas Center and reversing the outcome. Anna Foley sat in the locker room after the defeat to Springfield Central and vowed she would return victorious as a senior.

Friday night, the top-seeded Golden Warriors completed their perfect revenge tour with a 55-51 victory over Bishop Feehan in this years championship game. The triumph capped Andovers undefeated 26-0 season and delivered the program its sixth state title, including a 2020 co-championship.

We deserved it. Any doubt that I had, I had to just tell myself, like, I deserve this, said Foley, who had a game-hgh 20 points. We deserve this. Weve worked so hard for this and its just a long time coming.

Andover knew beating the Shamrocks (20-5) would be difficult after grinding out a similar 46-42 win at the Comcast Tournament in February. After the Golden Warriors built an early lead, Bishop Feehan clawed back and got as close as 53-51 when Mary Daley swished a late 3-pointer. But Michaela Buckley knocked down a pair of free throws to ice the win for Andover.

All the games that weve played helped us in these moments, said Andover coach Alan Hibino. We keep telling them, Theres not too many things that you havent faced in four years.

The Warriors dilligently fought to gain traction, leading 17-14 after one quarter and 33-25 at halftime. As co-stars Foley and Amelia Hanscom heated up, so did the team. Foley often directed the offense from the top of the arc while Hanscom rolled off of screens and cut to the basket.

The dynamic duo also used their size advantage to power to the basket on drives. While Foley led the team in scoring, mixing some tough rim attacks with some timely perimeter shooting to go along with three blocked shots, Hanscom added a complementary 18 points in a perfect conclusion to their four-year reign.

Everything Ive worked on my whole life with Andover basketball shooting, driving, passing [its about] just been playing with my friends, just playing basketball, Foley said.

Bishop Feehan didnt go away though. Hanscom fouled out early in the fourth quarter and the Shamrocks used that frustration to rally from a 12-point deficit. Junior Julia Webster (15 points) and Charlotte Adams-Lopez (11 points) led the Shamrocks in the loss.

They made threes; [Olivia Fransiscus] made two big ones, Hibino said. They just kept coming. They were relentless defensively.

The Warriors did not play in a fall-ball offseason league, opting to let multi-sport athletes shine before attacking winter with a renewed dedication. They worked with former Syracuse basketball player Kaleb Joseph on honing a healthy mental approach to basketball. All of the extra work paid off with a storybook season.

I feel on top of the world, Hanscom said. Its insane. Last game of our high school career, we just won the state championship. Its what everyone would want out of their last game ever.

Division 1 girls final box

at Tsongas Center, Lowell

Bishop Feehan (20-6) 1411121451

Andover (26-0) 171614 855

BISHOP FEEHAN Maddy Steel 2 1 6, Charlotte Adams-Lopez 3 4 11, Mary Daley 3 2 9, Julia Webster 7 1 15, Olivia Franciscus 2 0 6, Sam Reale 2 0 4. Totals 19 8 51.

ANDOVER Michaela Buckley 1 4 6, Amelia Hanscom 8 1 18, Kathleen Yates 3 0 6, Ella Vidoni 2 0 5, Anna Foley 8 3 20. Totals 22 8 55.

3-pt. goals: BF Maddy Steel, Charlotte Adams-Lopez, Mary Daley, Olivia Franciscus 2; A Amelia Hanscom, Ella Vidoni, Anna Foley.

Continued here:
Perfect finish: Andover girls' basketball punctuates its 26-0 run with a ... - msnNOW

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