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Metabolic Demands of The Human Brain

The brain is dependent on a constant supply of glucose as it doesnt have any storage capacity in itself to store glucose as glucagon. In addition to this, the brain doesnt use alternative sources of fuel such as fatty acids which is believed to be due to an evolutionary protective mechanism from the harmful effects of fatty acid oxidation. Thus, due to its reliance on glucose for fuel the brain can only derive its energy via aerobic glycolysis and oxidative phosphorylation. Although it can also use ketone bodies, this fuel source is limited and not as efficient as glucose.

Read Also: HGH Improves Memory In Stroke Victims Study Shows

The brain is a highly heterogeneous organ in terms of its functions and cell type. Different nerve cells have a variety of functions and thus a variable demand for energy. More than 20% of the bodys energy is consumed by the brain although it accounts for less than 2% of the total body mass. This energy as stated above is produced by aerobic glycolysis which is dependent on oxygen therefore oxygen levels is a significant factor that influences brain cells functionality. Despite a large number of studies conducted on understanding the metabolic processes of the brain, the amount of oxygen consumption by the brain has not been known until now.

Neurobiologists from LMU have recently calculated the amount of oxygen the human brain consumes based on the activity of some nerve cells. For the first time in the history of medical science, neurobiologists Hans Straka, Suzan zugur, and Lars Kunz have discovered a method to directly measure the oxygen consumed by the brain by correlating it with the neural cell functions.

Read Also: Brain Cancer: A Promising New Treatment for Destroying Aggressive Glioblastoma Cell

Using electrochemical sensors in tadpoles, the neuroscientists determined the concentration of oxygen in the brain. This technique enabled them to control the oxygen levels within the brain while simultaneously inhibiting brain function by controlling nerve cell functional activity using pharmacological inhibitors of neurotransmitters. By examining eye movements while controlling nerve cell activity, the neurobiologists analyzed the association of nerve cell function with oxygen consumption.

We have found that the brain is anoxic in a normal air-saturated environment, which means that no oxygen can be measured, said Straka. Read Also: New Brain Surgery Technique Makes Cancer Cells More Visible for RemovalAny oxygen consumed by the nerve cells is immediately utilized for aerobic glycolysis for energy. However, if oxygen saturation levels of the atmosphere were twice the normal concentration, the utilization of oxygen for energy was saturated creating an abundance of oxygen within the brain. For nerve cell activity, only half of the oxygen was used while the remaining half was required by glial cells to maintain the basic metabolic rate of both glial cells and nerve cells. But in situations of increased brain activity, more oxygen was utilized for nerve cell activity than basic metabolic rate.

Understanding the influence of oxygen saturation or deficiency with brain activity is a crucial step to further research the mechanism by which our brain processes information.

Relationship between oxygen consumption and neuronal activity in a defined neural circuit

Read more here:
Neurobiologists Calculate Oxygen Consumed By The Brain - Gilmore Health News

Intermittent fasting is one of the top lifestyle trends this year.

And thats not only because we came out of COVID-19 looking a little chubbier and tubbier, but also because it has proven results with (relatively) little effort required.

Nevertheless, as with all diets (and diet fads), its important to be properly informed before embarking on a journey of changing your eating habits.

Here, Dr Priya Khorana, founder and CEO of Lifestyle Nutrition Consulting Co in Bangkok, gives us the ultimate low-down on intermittent fasting, from the perspective of someone who really knows a thing or two about this stuff. Read on, take note, and decide for yourself if youre ready to (stomach) rumble.

Intermittent fasting (IF) is not a diet. It is a timed approach to eating, and unlike a restricted fad diet, it does not specify what foods a person should eat or avoid. To put simply; IF does not change what you eat, it changes when you eat.

It may have some health benefits, including weight loss and improved insulin sensitivity, but it is not suitable for everyone and should be done with careful consideration. People with advanced diabetes or who are on medications for diabetes, people with a history of eating disorders like anorexia and bulimia, and pregnant or breastfeeding women should not attempt intermittent fasting unless under the close supervision of a physician who can monitor them.

Having said that, there are some evidence-based benefits of IF. In men, it has shown to reduce insulin resistance and lower blood sugar levels (and thereby reducing the risk of type 2 diabetes). It has also been shown to reduce oxidative damage and inflammation, thereby slowing down effects of ageing. Lastly, the insulin levels drop human growth hormone (HGH) increases, which helps facilitate fat burning and muscle gain.

Depending on your IF approach, youre either shortening the eating window each day, or engaging in 24-hour fasts one or more times a week. One of the most popular approaches is the 16:8 method, which is when you fast for an eight-hour window this is often the approach I go for. It is vital to stress that folks use an eating approach that works and is sustainable to them.

The 16:8 MethodThis is also called the Leangains Protocol, and involves skipping breakfast and restricting your daily eating period to 8 hours, such as 1-9pm. Then you fast for 16 hours in between.

The Eat-Stop-EatThis involves fasting for 24 hours, once or twice a week. For example, you may not eat from dinner one day until dinner the next day.

The 5:2 DietWith this method, you consume only 500-600 calories on two non-consecutive days of the week, but eat normally the other 5 days.

As a doctor of nutrition, I will always recommend foods for improved health, including high-fiber, unprocessed, whole foods in all colours and varieties. A mostly plant-based Mediterranean-style diet has been linked to improved health benefits, and in this case, I will suggest this way of life even whilst fasting. Making sure you are nourishing your body as effectively prior to starting your fast will help prevent any feelings of being hangry during the fast.

It is also vital for me to suggest that if you are embarking on an IF journey, staying hydrated is key. Fasting can come with some initial side effects, such as increased hunger, low blood sugar, headache, irritability, dizziness, and fatigue so please embark with caution.

Limiting your dining window does not give you an excuse to binge eat especially on unhealthy foods because you will not see the benefits. Eating unwholesome (read: junk) food in a shortened feeding window on the IF diet may also put you at risk of deficiencies in key nutrients such as calcium, iron, protein, and fiber, all of which are essential for normal biological function.

What you need to do is consume a diet rich in fruits and vegetables, whole-grains, and sufficient lean protein and healthy fat boosting important antioxidants and nutrients which all result in an increased lifespan and reduces the risks of developing lifestyle related chronic diseases.

What is important to emphasise is that the goal of IF is to maintain a healthy amount of calories for your body during the fast so you do not rebound eat.

For those starting out, I suggest implementing a 12-hour fasting/12-hour eating window and building up from there, eventually finding a schedule that works best for you. The most important thing is breaking your fast with fresh, unprocessed, nutrient-dense whole foods, prioritising healthy sources of protein and good fats, all while limiting junk foods that negate any benefits of IF.

This story first appeared on Lifestyle Asia Bangkok

(Featured and main photos: Brooke Lark/ Unsplash)

See the article here:
Here's everything you need to know about intermittent fasting - Prestige Online

New Jersey, United States,- Market Research Intellect sheds light on the market scope, potential, and performance perspective of the Global Human Growth Hormone (hGH) Market by carrying out an extensive market analysis. Pivotal market aspects like market trends, the shift in customer preferences, fluctuating consumption, cost volatility, the product range available in the market, growth rate, drivers and constraints, financial standing, and challenges existing in the market are comprehensively evaluated to deduce their impact on the growth of the market in the coming years. The report also gives an industry-wide competitive analysis, highlighting the different market segments, individual market share of leading players, and the contemporary market scenario and the most vital elements to study while assessing the global Human Growth Hormone (hGH) market.

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Leading Human Growth Hormone (hGH) manufacturers/companies operating at both regional and global levels:

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This study analyzes the growth of Human Growth Hormone (hGH) based on the present, past and futuristic data and will render complete information about the Human Growth Hormone (hGH) industry to the market-leading industry players that will guide the direction of the Human Growth Hormone (hGH) market through the forecast period. All of these players are analyzed in detail so as to get details concerning their recent announcements and partnerships, product/services, and investment strategies, among others.

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Human Growth Hormone (hGH) Market Growth By Manufacturers, Type And Application, Forecast To 2026 - 3rd Watch News

Supports the investigation of TransCon hGH for treatment of growth hormone deficiency in the pediatric population from 6 months to less than 18 years of age

Company on track to submit European marketing application in third quarter 2020

No additional studies required

COPENHAGEN, Denmark, July 06, 2020 (GLOBE NEWSWIRE) -- Ascendis Pharma A/S(Nasdaq: ASND), a biopharmaceutical company that utilizes its innovative TransCon technologies to address unmet medical needs, today announced that it received a positive opinion from the Paediatric Committee (PDCO) of the European Medicines Agency (EMA) on its agreement with the proposed Paediatric Investigation Plan (PIP) for TransCon hGH (lonapegsomatropin), an investigational long-acting once-weekly prodrug of somatropin (human growth hormone or hGH) in development for treatment of growth hormone deficiency (GHD). The positive opinion is based on the non-clinical safety program, as well as data from the three phase 3 clinical trials provided to PDCO from the ongoing TransCon hGH development program, which will be included in the upcoming Marketing Authorisation Application (MAA).

The PIP opinion from PDCO endorsed the TransCon hGH program as acceptable for assessment of safety and efficacy for the use of TransCon hGH as a treatment for growth hormone deficiency in children from 6 months to less than 18 years of age, mirroring the population covered by the studies conducted in the program.

We are delighted to receive the positive opinion from PDCO regarding our PIP, which is based on a comprehensive data package from our non-clinical and clinical development program for TransCon hGH. As planned, we will move forward with our marketing application submission in Europe this quarter, said Dana Pizzuti, M.D., Ascendis Pharmas Senior Vice President of Development Operations. We believe this opinion recognizes the unique attributes of TransCon hGH and how our TransCon technology enables the long-acting release of unmodified somatropin which provides a predictable mode of action without changing the expected safety profile. We are very pleased with our PDCO discussions as the approval of our PIP reflects to our knowledge the first time PDCO has concluded that a clinical development program for a long acting growth hormone treatment is appropriate to support the clinical development in children.

Ascendis submitted a Biologics License Application for TransCon hGH for the treatment of pediatric GHD to the U.S. Food and Drug Administration in June 2020, and the company recently conducted productive meetings with European regulatory personnel, including a pre-submission meeting with EMA and meetings with the rapporteur and co-rapporteur.

About the Paediatric Committee (PDCO)

The Paediatric Committee (PDCO) is the European Medicines Agency's (EMA) scientific committee responsible for activities on medicines for children and to support the development of such medicines in the European Union by providing scientific expertise and defining paediatric needs.

About the Paediatric Investigation Plan (PIP)

A paediatric investigation plan (PIP) is a development plan aimed at ensuring that the necessary data are obtained through studies in children, to support the authorisation of a medicine for children. All applications for marketing authorisation for new medicines have to include the results of studies as described in an agreed PIP, unless the medicine is exempt because of a deferral or waiver. This requirement also applies when a marketing-authorisation holder wants to add a new indication, pharmaceutical form or route of administration for a medicine that is already authorised and covered by intellectual property rights.

About TransCon Technology

TransCon refers to transient conjugation. The proprietary TransCon platform is an innovative technology designed to create new therapies that optimize therapeutic effect, including efficacy, safety and dosing frequency. TransCon molecules have three components: an unmodified parent drug, an inert carrier that protects it, and a linker that temporarily binds the two. When bound, the carrier inactivates and shields the parent drug from clearance. When injected into the body, physiologic conditions (e.g., pH and temperature) initiate the release of the active, unmodified parent drug in a predictable manner. Because the parent drug is unmodified, its original mode of action may be maintained. TransCon technology is designed to be applied broadly to a protein, peptide or small molecule in multiple therapeutic areas, and to be used systemically or locally.

About Pediatric Growth Hormone Deficiency (GHD)

Pediatric GHD is a serious orphan disease caused when the pituitary gland does not produce enough growth hormone. Children with GHD are not only characterized by short stature, but they also may experience metabolic abnormalities, psychosocial challenges and poor quality of life.

For decades, the standard of care for GHD has been a daily subcutaneous injection of hGH, which improves growth and overall endocrine health.

About Ascendis Pharma A/S

Ascendis Pharma is applying its innovative platform technology to build a leading, fully integrated biopharma company focused on making a meaningful difference in patients lives. Guided by its core values of patients, science and passion, the company utilizes its TransCon technologies to create new and potentially best-in-class therapies.

Ascendis Pharma currently has a pipeline of three independent endocrinology rare disease product candidates in clinical development and is advancing oncology as its second therapeutic area of focus. The company continues to expand into additional therapeutic areas to address unmet patient needs.

Ascendis is headquartered in Copenhagen, Denmark, with additional offices in Heidelberg and Berlin, Germany, and in Palo Alto and Redwood City, California.

For more information, please visit http://www.ascendispharma.com.

Forward-Looking Statements

This press release contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, included in this press release regarding our future operations, plans and objectives of management are forward-looking statements. Examples of such statements include, but are not limited to, statements relating to (i) our plans to submit a MAA for TransCon hGH to the EMA in the third quarter of 2020, (ii) our ability to apply our platform technology to build a leading, fully integrated biopharma company, (iii) our expectations regarding our ability to create potentially best-in-class therapies and (iv) our product pipeline. We may not actually achieve the plans, carry out the intentions or meet the expectations or projections disclosed in the forward-looking statements and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions, expectations and projections disclosed in the forward-looking statements. Various important factors could cause actual results or events to differ materially from the forward-looking statements that we make, including the following: unforeseen safety or efficacy results in our TransCon hGH, TransCon PTH and TransCon CNP or other development programs; unforeseen expenses related to the development and potential commercialization of TransCon hGH, TransCon PTH and TransCon CNP or other development programs, general and administrative expenses, other research and development expenses and our business generally; delays in the development of TransCon hGH, TransCon PTH and TransCon CNP or other development programs related to manufacturing, regulatory requirements, speed of patient recruitment or other unforeseen delays; dependence on third party manufacturers to supply study drug for planned clinical studies; our ability to obtain additional funding, if needed, to support our business activities and the effects on our business of the worldwide COVID-19 pandemic. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to our business in general, see our current and future reports filed with, or submitted to, theU.S. Securities and Exchange Commission(SEC), including our Annual Report on Form 20-F filed with the SEC on April 3, 2020. Forward-looking statements do not reflect the potential impact of any future in-licensing, collaborations, acquisitions, mergers, dispositions, joint ventures, or investments we may enter into or make. We do not assume any obligation to update any forward-looking statements, except as required by law.

Ascendis, Ascendis Pharma, the Ascendis Pharma logo, the company logo and TransCon are trademarks owned by the Ascendis Pharma group. July 2020 Ascendis Pharma A/S.

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Ascendis Pharma A/S Receives Positive Opinion from the Paediatric Committee of the European Medicines Agency on the Agreement of a Paediatric...

Human Growth Hormone hGH Market Latest Research Report 2020:

The Human Growth Hormone hGH report provides an independent information about the Human Growth Hormone hGH industry supported by extensive research on factors such as industry segments size & trends, inhibitors, dynamics, drivers, opportunities & challenges, environment & policy, cost overview, porters five force analysis, and key companies

Download Premium Sample Copy Of This Report: Download FREE Sample PDF!

In this report, our team offers a thorough investigation of Human Growth Hormone hGH Market, SWOT examination of the most prominent players right now. Alongside an industrial chain, market measurements regarding revenue, sales, value, capacity, regional market examination, section insightful information, and market forecast are offered in the full investigation, and so forth.

Scope of Human Growth Hormone hGH Market:Products in the Human Growth Hormone hGH classification furnish clients with assets to get ready for tests, tests, and evaluations.

Major Company Profiles Covered in This Report

Eli Lilly and Company, Ferring Holding SA, Genentech, Merck & Co., Novo Nordisk, Pfizer, Sandoz International GmbH, Ipsen,

1. To provide a detailed investigation of the market structure alongside conjecture of the different sections and sub-portions of the worldwide Human Growth Hormone hGH Market.

Human Growth Hormone hGH Market Report Covers the Following Segments:

Market segment by Type, the product can be split into

Recombinant Human Growth Hormone (rhGH), Human Growth Hormone (rhGH),

Market segment by Application, split into

Growth Hormone Deficiency, Turner Syndrome, Idiopathic Short Stature, Prader-Willi Syndrome, Small for Gestational Age, Others,

Market segment by Regions/Countries, this report covers

United States

Europe

China

Japan

Southeast Asia

India

Central & South America

North America

Europe

Asia-Pacific

South America

Center East and Africa

United States, Canada and Mexico

Germany, France, UK, Russia and Italy

China, Japan, Korea, India and Southeast Asia

Brazil, Argentina, Colombia

Saudi Arabia, UAE, Egypt, Nigeria and South Africa

Table of Content:

Market Overview:The report begins with this section where product overview and highlights of product and application segments of the global Human Growth Hormone hGH Market are provided. Highlights of the segmentation study include price, revenue, sales, sales growth rate, and market share by product.

Competition by Company:Here, the competition in the Worldwide Human Growth Hormone hGH Market is analyzed, By price, revenue, sales, and market share by company, market rate, competitive situations Landscape, and latest trends, merger, expansion, acquisition, and market shares of top companies.

Company Profiles and Sales Data:As the name suggests, this section gives the sales data of key players of the global Human Growth Hormone hGH Market as well as some useful information on their business. It talks about the gross margin, price, revenue, products, and their specifications, type, applications, competitors, manufacturing base, and the main business of key players operating in the global Human Growth Hormone hGH Market.

Market Status and Outlook by Region:In this section, the report discusses about gross margin, sales, revenue, production, market share, CAGR, and market size by region. Here, the global Human Growth Hormone hGH Market is deeply analyzed on the basis of regions and countries such as North America, Europe, China, India, Japan, and the MEA.

Application or End User:This section of the research study shows how different end-user/application segments contribute to the global Human Growth Hormone hGH Market.

Market Forecast:Here, the report offers a complete forecast of the global Human Growth Hormone hGH Market by product, application, and region. It also offers global sales and revenue forecast for all years of the forecast period.

Research Findings and Conclusion:This is one of the last sections of the report where the findings of the analysts and the conclusion of the research study are provided.

For detailed informationhttps://brandessenceresearch.biz/Lifesciences-and-Healthcare/Global-and-China-Human-Growth-Hormone-hGH-Market-Research-by-Company-TypeApplication-2013-2025/Summary

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Human Growth Hormone hGH MARKET OVERVIEW WITH DETAILED ANALYSIS, COMPETITIVE LANDSCAPE, FORECAST TO 2025 - 3rd Watch News

It has been a tough enough time for boxing with the whole coronavirus lockdown and then Jarrell Miller comes along to remind us about the curse of drugs within the sport.

iller missed out on a world heavyweight title fight with Anthony Joshua last year after he tested positive for the performance-enhancing drugs GW1516, HGH and IPO. He was to have made his return to the ring this month but has tested positive for GW1516 again, though he is adamant that he did not take the substance on purpose.

Fans and fighters will make their own minds up about whether he is guilty or not of taking it on purpose, but the fact remains that it was found in his system. In my opinion, he should have been chucked out of the sport after last year's positive tests and one thing I will always take pride in when my career is over is that I gave my all doing it the right away, being clean.

This latest controversy as well as the disconcerting rumours I hear about some gyms the States sadly leads me to have a real fear that the use of performance-enhancing drugs is worse than ever in boxing - even though there has been more testing.

Let's be honest, when you see a fighter go from being a light hitter with few knockouts or stoppages to someone who is rocking fighters to their bootstraps, it does raise eyebrows.

Unfortunately, the rumour mill in boxing is growing all the time about who is possibly using PEDs and even four or five years ago that wouldn't have been the case. It seems there is a growing culture that reflects what happened in cycling and athletics - that you have to take them because everyone else is. That's a crying shame and it's not the case, you can't tar every fighter with the same brush but there is a real concern that more and more boxers may be getting away with PED use. That's why it was such a mistake by the World Anti-Doping Association to announce during lockdown that they were not doing any testing. That was just a green light for the cheats to get on the gear!

I have recently filled out my latest form for UKAD to tell them about my whereabouts for the next three months so they can test me whenever they want and it should be the same for every fighter.

I still don't believe the governing bodies are taking the whole issue of drug use seriously enough and you do wonder if it will take a tragedy for those in authority to raise their game.

The problem in America is that they have different rules in each State and that needs to change immediately because the PED curse has to be crushed.

I don't know how anyone can cheat by using the drugs and then gain any sort of satisfaction from winning a fight when they know that they've been juiced to the eyeballs. But it seems that temptation to cheat to earn a living is just too great for some.

Our sport really needs to protect its reputation and be ruthless with PED cheats - they have to be kicked out. Miller is appealing his latest positive test but if that fails then that has to be the end of his ring career.

If, on the other hand, he is given another chance, it sends a signal that it's worth taking the risk of cheating in a sport in which men and women can be maimed for life or killed.

See original here:
Carl Frampton: I fear that drugs use in boxing could be rife and something needs to be done about it - Belfast Telegraph

Intermittent fasting is one of the top lifestyle trends this year not only because we came out of COVID-19 looking a little chubbier and tubbier, but also because it has proven results with (relatively) little effort required. Nevertheless, as with all diets (and diet fads), its important to be properly informed before embarking on a journey of changing your eating habits.

Here, Dr Priya Khorana gives us the ultimate low-down on intermittent fasting, from the perspective of someone who really knows a thing or two about this stuff. Read on, take note, and decide for yourself if youre ready to (stomach) rumble.

Intermittent fasting (IF) is not a diet. It is a timed approach to eating, and unlike a restricted fad diet, it does not specify what foods a person should eat or avoid. To put simply; IF does not change what you eat, it changes when you eat.

It may have some health benefits, including weight loss and improved insulin sensitivity, but it is not suitable for everyone and should be done with careful consideration. People with advanced diabetes or who are on medications for diabetes, people with a history of eating disorders like anorexia and bulimia, and pregnant or breastfeeding women should not attempt intermittent fasting unless under the close supervision of a physician who can monitor them.

Having said that, there are some evidence-based benefits of IF. In men, it has shown to reduce insulin resistance and lower blood sugar levels (and thereby reducing the risk of type 2 diabetes). It has also been shown to reduce oxidative damage and inflammation, thereby slowing down the effects of ageing. Lastly, the insulin levels drop human growth hormone (HGH) increases, which helps facilitate fat burning and muscle gain.

Depending on your IF approach, youre either shortening the eating window each day or engaging in 24-hour fasts one or more times a week. One of the most popular approaches is the 16:8 method, which is when you fast for an eight-hour window this is often the approach I go for. It is vital to stress that folks use an eating approach that works and is sustainable to them.

The 16:8 MethodThis is also called the Leangains Protocol and involves skipping breakfast and restricting your daily eating period to 8 hours, such as 1-9:00 pm. Then you fast for 16 hours in between.

The Eat-Stop-EatThis involves fasting for 24 hours, once or twice a week. For example, you may not eat from dinner one day until dinner the next day.

The 5:2 DietWith this method, you consume only 500-600 calories on two non-consecutive days of the week but eat normally the other 5 days.

As a doctor of nutrition, I will always recommend foods for improved health, including high-fibre, unprocessed, whole foods in all colours and varieties. A mostly plant-based Mediterranean-style diet has been linked to improved health benefits, and in this case, I will suggest this way of life even whilst fasting. Making sure you are nourishing your body as effectively prior to starting your fast will help prevent any feelings of being hangry during the fast.

It is also vital for me to suggest that if you are embarking on an IF journey, staying hydrated is key. Fasting can come with some initial side effects, such as increased hunger, low blood sugar, headache, irritability, dizziness, and fatigue so please embark with caution.

Limiting your dining window does not give you an excuse to binge eat especially on unhealthy foods because you will not see the benefits. Eating unwholesome (read: junk) food in a shortened feeding window on the IF diet may also put you at risk of deficiencies in key nutrients such as calcium, iron, protein, and fibre, all of which are essential for normal biological function.

What you need to do is consume a diet rich in fruits and vegetables, whole-grains, and sufficient lean protein and healthy fat boosting important antioxidants and nutrients which all result in an increased lifespan and reduces the risks of developing lifestyle-related chronic diseases.

What is important to emphasise is that the goal of IF is to maintain a healthy amount of calories for your body during the fast so you do not rebound eat.

For those starting out, I suggest implementing a 12-hour fasting/12-hour eating window and building up from there, eventually finding a schedule that works best for you. The most important thing is breaking your fast with fresh, unprocessed, nutrient-dense whole foods, prioritising healthy sources of protein and good fats, all while limiting junk foods that negate any benefits of IF.

For more super-nutritious advice and information, be sure to follow the fabulous Priya over onInstagramandFacebook.

Featured and hero image: Courtesy Malvestida Magazine/Unsplash

This story first appeared on Lifestyle Asia Bangkok.

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Global trade impact of the Coronavirus Human Growth Hormone (HGH) Market Poised for Steady Growth in the Future 2018 to 2028 - Owned

This year, WayForward is celebrating their 30th anniversary with the release of the latest entry in their flagship Shantae series titled Shantae and the Seven Sirens. I quickly fell in love with the Shantae series after playing Pirates Curse and Half-Genie Hero on my Nintendo Switch, and I couldnt wait for the chance to play the next offering in the series. I recently completed Seven Sirens and wanted to share my thoughts on the game and how it compares to the previous titles. This review will focus on the Nintendo Switch version, and the experience may vary on other platforms.

The protagonist is a half-genie, half-human named Shantae. This game opens with Shantae and her friends on a vacation getaway to Paradise Island. Shantae was invited to partake in the islands Half-Genie Festival with other Half-Genies like herself. But when the festivities got underway, the lights went dark, and when they came back to, she was left alone on the stage. Its up to Shantae to find her missing Half-Genie friends.

She runs into her old nemesis, Risky Boots, and immediately suspects that she is behind the disappearances. Risky is certainly up to no good, but theres more to it than meets the eye. Theres a legend about creatures known as Sirens that live deep beneath the island and have been terrorizing the land for a long time. Shantae has to fight these Sirens and rescue the Half-Genies. It all leads up to the final battle to determine the fate of Paradise Island. There were some twists and turns, but its more fun if you play the game to find out.

No time for vacationing after Harmony and her friends mysteriously vanished at the Half-Genie Festival.

With Seven Sirens comes the return of the familiar Metroidvania style the series is famous for, after Half-Genie Heros departure of it in favor of a more linear experience. Its very much like Pirates Curse in that youll need to revisit different zones once youve properly equipped yourself with the powers necessary to advance in the map or acquire items. The mode of travel is different this time around. In Shantae and the Pirates Curse, you needed to go to Riskys ship to sail to different locations. In Shantae: Half-Genie Hero, you needed to visit Sky and ride on her bird Wrench to your desired location. In this game, you use warp rooms, which have platforms you jump on that teleport you to specific spots. As you advance through the map, youll unlock more warp rooms above and below Paradise Island. There is no Scuttle Town in this game, but there are three towns instead, including Arena Town, Tree Town, and Armor Town.

I like the controls overall and the new ways that magic was implemented into the game. Most of the basic controls still apply. You can whip your hair at enemies (while upgrading them to be faster and more damaging) or you can cycle through an assortment of magic weapons such as fireballs, pike balls, rockets, and scimitars. You can buy these power-ups in shops using the in-game gem currency. But there are new ways in which transformations are implemented. Shantae and the Seven Sirensintroduces Fusion Magic, which are powers you inherit from your half-genie comrades. There are two kinds of this magic: Fusion Forms, which allow you to transform with a dedicated button, and Fusion Dances, where you can dance to activate a special power. For example, you can Fusion Form into a Newt, which allows you to zip through the air and climb walls. There is also the Seer Dance, which when performed will make hidden objects appear on the screen.

There are up to nine different ways to transform, including the Quake Dance.

It may sound complex, but I enjoyed how much quicker its made the gameplay experience. If I need to drill through the dirt I dont need to dance; as long as I acquired the Drill Coin, I just need to move in the direction I want to drill and Shantae will instantly transform as needed. Speaking of power-ups, another new addition comes in the form of monster cards. These are cards that appear at random as you defeat different enemies in the game. They all have different perks, such as boosts in the attack, defense, speed, magic meters, etc. There are rare cards in the game that can only be acquired through villagers by trading in nuggets, which can be found hidden throughout the map.

My only gripe here is some of these rare cards are practically worthless relative to when they can be acquired in the story. There are also heart squids you can find and trade to the Squidsmith for extra heart holders (basically extends your life meter; think of heart containers from Legend of Zelda), as well as hidden statues and treasure chests. Your magic is the key to unlocking the secrets of Paradise Island.

Collect gems and spend them at the town shops to add magic weapons to your arsenal.

In terms of difficulty, the game isnt that hard once you get the hang of the controls and figure out how to stock up on items. Its still challenging and can be even more so if youre a completionist who doesnt believe in using guides (there are some hidden items that I dont know how I would have found if not for guides and YouTube videos). I appreciate that WayForward showed some mercy and didnt have a stupidly difficult timing jump thing with spikes like it did in the final levels of the previous two games. Seriously. I needed to exploit a glitch just to get up that tower in Pirates Curse. It was ridiculous, but thats on me.

Boss battles in Seven Sirens felt fairly simple to me, similar to past Shantae games. The key is to always take advantage of the powers you had most recently acquired. Its sort of like Mega Man in a sense. I want to add that the final boss battle felt the most epic of all the Shantae games that Ive played, at least from a visual standpoint. For me thats saying something, considering I got chills while battling Tinkerbrain in HGH.

Gorgeous animated cutscenes appear as you face new obstacles such as the Sirens.

Also want to mention that there is a New Game Plus mode, where you play as Shantae in her hula costume, and get a higher magic meter but less defense. Im still in the middle of playing it and its noticeably more challenging. My experience is that the increased magic meter does not offset the amount of damage I can get, so I consider the margin for error to be smaller. Its given me an excuse to play the game all over again with a higher level of difficulty. Bring it on!

Half-Genie Hero had a couple of DLC packs that allowed you to play effectively new modes as other characters, such as Sky, Bolo, Rottytops, and even Risky Boots. I enjoyed those modes and it was a little disappointing that those characters are non-playable in this game. The awesome, anime-inspired intro (which Ill get into in a second) seemed to tease the possibility of playing as those characters but that simply wasnt the case. Its something I hope that will be considered for the sixth installment of Shantae in the future.

When I was at PAX East earlier this year, I was able to play a demo of the game in what I now recognize is the Water Lily stage. What stood out to me then was that the game played similarly to Pirates Curse but the sprites still resembled Half-Genie Hero. Now that Ive had a chance to play the game in full, Ive been able to greater appreciate its visual aspects. Yes, they recycled some assets from HGH, but I prefer it to the pixelated look from Pirates Curse. I kind of liked the 3D-ish look of the levels in HGH so I missed seeing that here in Seven Sirens, but I dont mind sacrificing that for the sake of getting it back to its Metroidvania roots.

Solve puzzles and make new discoveries as you travel through the depths of the sunken city.

Ive always enjoyed the banter when Shantae speaks with other characters. There didnt seem to be as much of it in HGH (I need to emphasize that the previous game was a big departure from what the Shantae series was known for, which is why I keep bringing it up). Im glad the dialogue ramped back up with this one. Squid Baron is such a delightful dork, what a treat he is.

I was quite satisfied with how the game looked. Its a platformer so nothing too fancy needed, though I did appreciate the hand-drawn art of the background in those deep-water levels. The GUI was sleek and easy to navigate. Seven Sirens continues the Shantae tradition of cute and sexy character designs the series has always been known for. Im not exactly sure why this games ESRB rating went down from Teen to Everyone 10+, because as far as fantasy violence and suggestive themes are concerned, I saw no difference.

Youll need your Fusion Magic to defeat the lovely but deadly Water Lily Siren.

Another thing I loved was the addition of animated cutscenes.Beautiful stuff. Im a big fan of the cutscenes and hope we see more of them in the future. That includes the games introduction video, which was animated by Studio Trigger. What a tease! A Shantae animated series is something I didnt know I needed in my life.

(While were on that topic, hey Matt Bozon and WayForward! Cant you guys work something out with Netflix? Just need Cristina Vee on board and were Ret-2-Go! Make it happen! Okay let me get back on track)

Everyone waiting patiently for Shantae to be playable in Smash (j/k). The gangs all here on another adventure.

Let me get sound effects out of the way here. Nothing significant to report, its the same as usual. This game had a whopping nine different voice actors, more than double the previous game. I adore Vees work as Shantae (she voices two other characters in the game as well). Its the little details that I get a kick out of, like the sound of satisfaction when Shantae eats or drinks something, or when she yells out the name of her power. Too cute! Please never change.

What was significant, perhaps more than anything was the change with its soundtrack. There was a changing of the guard when long-time WayForward music composer Jake Kaufman announced that he left the company back in 2014. He had composed every Shantae game up to that point, and HGH was his final project in the series. Music is an art form that has the ability to move you through sound, and Kaufman was masterful at it with his video game soundtracks. The musical experience throughout Pirates Curse and Half-Genie Hero was remarkable, and the first thing I remembered about playing those games more than anything else. The File Select theme for Pirates Curse had no business being the absolute banger that it was. So imagine my disappointment when I discovered that this new installment to the Shantae series would no longer feature its super talented, long time composer.

You can use up to three monster cards at a time to enhance your abilities.

Kaufman set the bar high, so I had to set my expectations low and keep my mind open. Still, I was afraid, but I have to say WayForward somehow knocked it out of the park yet again. The soundtrack is made by a group headlined by Japanese composer and chiptune enthusiast Professor Sakamoto. I enjoyed its very distinctly 8-bit theme to the soundtrack (with the Beach Travel Easttrack being one of the more robust examples of this). Yet the music at times still managed to invoke those Arabian tones that have long been synonymous with Shantae soundtracks.

Ive read other peoples reactions to the game music and its definitely polarizing. Some consider it flat and bland; others love it. Im of the mind that, yes, this is very much not Jake Kaufmans work, but these tracks are still rock solid. They set the tone just right for every location in the game.The Seven Sirens soundtrack is available on Spotify and Apple Music. I have a Spotify subscription and there are a handful of tracks from the game that I go back to for a pick-me-up. I love it.

The new composition team proves to be worthy successors and Im so glad that such a vital component to the spirit of Shantae wasnt compromised. Thank you WayForward for not letting me down there.

If you like action, comedy, puzzles, and a healthy dose of fan service, Shantaes got you covered.

This game can be enjoyed by anyone, and prior knowledge of the series isnt required, but it helps to appreciate the context behind some of the character interactions. The game is fun on its own, but the backstory adds to it. I learned that from the first time I played a Shantae game and had the jokes go over my head. Shantae and the Pirates Curse was my introduction to the Shantae series. It was an experience that utterly wowed me and one that cant be duplicated because it was the first. That having been said, Seven Sirens incorporated many of the things that drew me into the franchise while introducing fresh new concepts that kept the game from feeling stale. It had just about everything that I could want from it: endearing characters and humor; great music and eye candy; a story with plot twists; lots of action and a large map to explore; familiar comforts with new delights.

If I had to nitpick, Id say that Seven Sirens didnt strike me as quite as challenging as it could have been.Shantae herself is pretty badass once youve gotten all the powers and loaded up on potions and monster cards. I would have liked for the map to have been just a little bit bigger and the game a little bit longer to beat. Its partially why I felt compelled to play it over with New Game Plus mode.

Shantae is the main hero but it would have been awesome if there was a chance to switch between characters, similar to the Friends to the End DLC in Half-Genie Hero. The Half-Genies give their powers to Shantae throughout the game but it would have been neat to be able to control them instead. Maybe alternate similar to Friends to the End, or going further back, the Teenage Mutant Ninja Turtles game for NES where you could pause and switch turtles. As the player I wouldve felt more drawn in to these newer characters. Theres so much potential with this series and the game left me wanting more, for better or worse. Thats about all I can think of in terms of room for improvement.

It was an absolute joy to play this game from start to finish. Shantae games deliver on the fun every time. I gravitate to video games that make me smile and laugh as I play, and this one did its job.I wanted more Shantae in my life, and after waiting patiently for the games release, WayForward finally granted my wish with Shantae and the Seven Sirens.

If youre ready to dance through the danger, you can pick up Shantae and the Seven Sirens today for Nintendo Switch, PlayStation 4, Xbox One, Steam, or Apple Arcade. Please leave a comment below and let me know what you think about this game. Thanks for reading and happy gaming!

Gain a new transformation when you get a Fusion Coin from your rescued ally.

Do battle with the Queen of the Seven Seas.

You can quickly travel across the map using warp rooms.

Belly dances unlock special powers.

This review was written based on a digital review copy of Shantae and the Seven Sirens for the Nintendo Switch provided by WayForward.

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Shantae and the Seven Sirens Nintendo Switch Review - A Wish Granted - The Koalition

In this report, the Global Infrared Search and Track (IRST) system market is valued at USD XX million in 2019 and is expected to reach USD XX million by the end of 2026, growing at a CAGR of XX% between 2019 and 2026. Global Infrared Search and Track (IRST) system market has been broken down by major regions, with complete market estimates on the basis of products/applications on a regional basis.

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The global Infrared Search and Track (IRST) system market size is projected to reach US$ XX million by 2026, from US$ XX million in 2020, at a CAGR of XX%% during 2021-2026.

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The report includes country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by Type, and by Application segment in terms of production capacity, price and revenue for the period 2015-2026.

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