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Mar 29

Exercise Tied to Reduced Parkinson’s Motor Symptoms, Increased … – Medscape

Physical exercise may improve the motor symptoms and quality of life for patients with Parkinson's disease (PD), new research shows.

A systematic review of 156 clinical trials involving 8000 patients with PD, showed dancing and aquatic exercise, in particular, were most likely to improve motor symptoms, while swimming, endurance training, and mind-body training were most likely to benefit quality of life (QoL).

Moritz Ernst

"For most types of exercise we studied, we observed positive effects on both the severity of motor signs and quality of life. These results highlight the importance of exercise in general, as they suggest people with Parkinson's disease can benefit from a variety of exercises," study investigator Moritz Ernst, MSc, deputy head of the working group on evidence-based medicine at the University Hospital Cologne in Cologne, Germany, told Medscape Medical News.

"Clinicians and people with PD may have several options of exercise programs to choose from when establishing an individual training routine," he added, emphasizing that overall those with PD should seek professional advice, including assessment of motor and nonmotor symptoms, to develop a training agenda based on their individual needs.

The study was published online earlier this year in the Cochrane Database of Systematic Reviews.

The investigators analyzed data from randomized, controlled trials comparing different types of exercise and no exercise and the subsequent effect on PD symptoms.

Exercise included dance, strength-resistance training, mind-body training such ad tai chi and yoga, water-based training, resistance training, gait/balance/functional training, and endurance training.

The average age of study participants ranged from 60 to 74 years, and most of the studies included patients with mild to moderate PD. The mean length of the various interventions was 12 weeks.

When the researchers examined the effect of exercise on motor symptoms, they found that dance (P = .88), aqua-based training (P = .69), and gait/balance/functional training (P = .67) were most likely to reduce symptom severity.

Aqua-based training (P = .95), endurance training (P = .77), and mind-body training (P = .75) were most were most likely to benefit QoL, although the investigators caution that these findings were at risk of bias because quality of life was self-reported.

The investigators note other study limitations including the fact that most of the studies included in the review had small sample sizes and their study only included patients with mild-to-moderate vs severe PD.

Ernst said that future research should include larger samples, report intent-to-treat analyses, and involve participants with more advanced forms of PD who may also have cognitive difficulties.

"We should be giving our patients, no matter where they are in their disease stage, a 'prescription' to exercise," Mitra Afshari, MD, MPH, told Medscape Medical News.

Dr Mitra Afshari

Afshari, who was not involved in the study, but leads her own research on PD and exercise as the site principal investigator on the NIH-funded SPARX3 Study in Parkinson's Disease and Exercise at Rush University in Chicago, Illinois, said that based on her experience caring for PD patients at all disease stages noted that "patients who have been physically active their whole lives and can maintain that activity despite their diagnosis fare the best."

However, she added, those who initiate physical exercise after diagnosis can also do very well and reap benefits, including improved motor symptoms.

The study was funded by University Hospital of Cologne, Faculty of Medicine and University Hospital, University of Cologne, Germany, and the German Ministry of Education and Research. The authors have disclosed no relevant financial relationships.

Cochrane Database Syst Rev. Published online January 5, 2023. Abstract

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Exercise Tied to Reduced Parkinson's Motor Symptoms, Increased ... - Medscape


Mar 29

Heart failure: Study finds exercise therapy safe and helps recovery – Medical News Today

Heart failure occurs when the heart can no longer pump blood and oxygen around the body. The condition represents around 8.5% of heart disease deaths in the United States.

Heart failure with preserved ejection fraction (HFpEF) causes around half of heart failure cases in the U.S. It happens when the hearts left ventricle stiffens, increasing pressure inside the heart.

Studies show that exercise improves physical and cardiac function in patients with HFpEF and may lead to better outcomes than medication.

Understanding more about how exercise could benefit those with heart failure could help physicians improve treatment plans for the condition.

Recently, researchers reviewed recent studies investigating the impact of supervised exercise therapy on those with chronic, stable HFpEF.

They found that supervised exercise therapy improves exercise capacity and quality of life among patients with heart HFpEF.

Currently in the United States, 1 in 2 Americans has diabetes or prediabetes and 3 in 4 are overweight or obese, said Dr. Melody H. Hermel, a cardiologist at United Medical Doctors in La Jolla, CA, not involved in the study, in an interview with Medical News Today.

To truly combat the comorbid conditions patients face, we need to combine traditional medication and procedures with nutrition, exercise, stress management, and preventative care to best address patients underlying risk factors and truly get at the heart of the matter, Dr. Hermel added.

Dr. Vandana Sachdev, a senior research clinician and the director of the Echocardiography Laboratory in the Division of Intramural Research at the National Heart, Lung, and Blood Institute (NHLBI), first author of the study, said in a press release:

Future work is needed to improve referral of appropriate patients to supervised exercise programs, and better strategies to improve long-term adherence to exercise training is needed. Hybrid programs combining supervised and home-based training may also be beneficial. Further, implementation efforts will need to include coverage by Medicare and other insurers.

The study was published in Circulation.

For the study, the researchers analyzed results from 11 randomized controlled trials investigating supervised exercise therapy on HFpEF outcomes.

The studies included over 700 participants, mostly aged between 60 and 70 years old. Participants engaged in various activities, including walking, Greek dancing, and high intensity training three times per week for 1-8 months.

Supervised exercise training also improved quality of life scores on the 21-point Minnesota Living with Heart Failure questionnaire by 4-9 points.

Exercising helps improve the hearts pumping ability, decreases blood vessel stiffness and improves the function and energy capacity of skeletal muscle, said Dr. Sachdev.

Exercise capacity is an independent, clinically meaningful patient outcome, and research has indicated that guided exercise therapy is actually more effective at improving quality of life for people who have HFpEF than most medications, she added.

Supervised exercise allows people to have their blood pressure, heart rate, breathing capacity observed when they are recovering from an illness or a procedure and there is uncertainty about their basic skills in exercise, ability to perform exercise or their ability to increase the intensity of exercise or to perform some types of exercise correctly, Dr. Charlie Porter, Cardio-oncologist at The University of Kansas Health System, not involved in the study, told MNT.

The benefits of exercise cannot be duplicated by medication or procedures. Regular exercise of 2.5 hours weekly or that equivalent increases life expectancy, reduces the incidence of heart disease complications, and has been linked to reduced risk for some cancers, such as colon. Improved sense of well-being or quality of life is consistently demonstrated in studies of sustained safe exercise, he added.

Increasing evidence indicates that resistance exercise is helpful in some neurologic disorders. Early signals suggest that resistance exercise may improve decline in cognitive function over time. There is no other intervention that can provide this array of established and probable benefits. There are no other interventions that can offer this array of established or probable benefits, he noted.

There are so many benefits to supervised exercise for many people, but there may be particular benefits for people who also have diabetes, are overweight or depressed, Dr. Martha Abshire Saylor, Ph.D., assistant professor at the Johns Hopkins School of Nursing, not involved in the study, told MNT.

Starting a supervised exercise program may have social support benefits, including encouragement and accountability for participation, but also will help with physiologic benefits like reducing inflammation and lipid levels, Dr. Saylor added.

Dr. Saylor cautioned, however, that supervision is key as vigorous physical activity can trigger acute cardiovascular events in those who are unfit, inactive, or with coronary artery disease.

Dr. Hermel added:

Supervised exercise programs such as cardiac rehab have demonstrated significant benefit for patients with recent heart attack or another acute coronary syndrome, chronic stable angina, congestive heart failure, pulmonary hypertension, after stent placement, coronary artery bypass surgery, heart valve surgery or cardiac transplant.

MNT also spoke to Dr. Yu-Ming Ni, a cardiologist of Non-Invasive Cardiology at MemorialCare Heart and Vascular Institute at Orange Coast Medical Center in Fountain Valley, CA, who was not involved in the study. Dr. Ni noted that the biggest obstacle to successful use of supervised exercise programs is adherence to exercise sessions.

Unlike in clinical trials, patients in real life are less likely to come to exercise sessions, and are not always committed to staying for the entire hour of exercise. Thus, patients who stand to gain the most from supervised exercise programs are those who are motivated to attend, he said.

When asked about limitations to the findings, Dr. Mirza Baig, a cardiologist with Memorial Hermann in Houston, Texas, not involved in the study, noted that the different studies included in the analyses had different selection criteria and endpoints.

Dr. Robert Segal, board certified cardiologist and founder of Manhattan Cardiology, Medical Offices of Manhattan, and co-founder of LabFinder, not involved in the study, also told MNT:

Women, low socioeconomic status, minority racial and ethnic groups were small percentages of the demographic that were studied. Most of the studies dont specify which type of heart failure (HFpEF vs Heart Failure With Reduced Ejection Fraction [HFrEF]) they are analyzing. The studies are short-term studies, a year or less. There were also issues with adherence to the exercise programs.

Dr. Adedapo Iluyomade, a preventive cardiologist at Baptist Health Miami Cardiac & Vascular Institute, also not involved in the study, told MNT:

There are several evidence gaps that need to be addressed, including the optimal exercise modalities, strategies to increase long-term adherence, and the use of exercise therapy for patients recently hospitalized with acute, decompensated heart failure.

Further research is needed to determine the potential effects of exercise-based therapies on hospitalization, death, cardiovascular events, and healthcare expenditures, as well as in the prevention of HFpEF in patients with multiple risk factors, Dr. Illuyomade noted.

This statement makes it clear that it is time for Medicare and Health plans to support the provision of supervised exercise programs to patients with HFpEF. The body of knowledge cited in this report indicates that further delays in expanding access to this important component of care is unwarranted, noted Dr. Porter.

Dr. Ni added:

Physicians should recommend supervised exercise programs to patients with heart failure with preserved fractions who are willing to attend regularly. If not qualified by insurance, physicians should recommend home exercise for patients with heart failure, as there are certainly enough benefits from exercise to justify routinely recommending it.

Patients with heart failure should take advantage of exercise programs covered by insurance to improve exercise capacity and quality of life.

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Heart failure: Study finds exercise therapy safe and helps recovery - Medical News Today


Mar 29

8 Exercises for Men To Stay Fit After 50 – Eat This, Not That

Staying fit as you age can be quite the challenge. Between the loss of muscle mass, strength, mobility, and testosterone, aging can catch up to men quickly after they reach 50. Additionally, poor exercise programs can lead to back pain and other lingering issues that you begin to notice as you age. The good news is that there are plenty of great exercises for men to stay fit after 50. In fact, you can actually reverse some effects of aging through resistance training and regular exercise.

The following are my top eight exercises for men to stay fit after 50. Perform three sets of eight to 12 repetitions per exercise one to two times per week. When combined with a good diet and healthy lifestyle, this workout program can help you age gracefully, stay in great shape, and maintain independence after hitting 50.

As with any new exercise routine, it's always a smart idea to check in with a certified fitness or medical professional to see what movements receive the green light for you to safely perform at your age and stage of life. Exercising should not be a painful experience, so if you ever experience any sort of pain, you should immediately stop and reevaluate again with a professional.

Keep reading to learn all about the best exercises for men to stay fit after 50, and for more workout inspiration, check out 7 Best Exercises for Men to Gain Muscle Without Equipment.

I recommend squats for virtually every client capable of performing them. You don't have to use a barbell squat, either. Choose a squat method that challenges you but remains doable. This can mean doing box squats with just your body weight, adding a kettlebell to perform a goblet squat, or going heavier with barbell squats.

Regardless of which squat variation you choose, keep your knees in line with your toes, avoid letting your torso fall forward, and aim to get your thighs parallel to the floor.

Keeping your upper body strong and maintaining the range of motion in your shoulders is vital for overall fitness and day-to-day strength. Choose overhand, neutral, or reverse grip pull-ups. If you cannot perform pull-ups with your body weight, you can perform negative pull-ups by jumping to the top of the bar and slowly lowering yourself.

RELATED: The Ultimate Muscle-Building Workout Every Man Over 40 Should Try

Pushups are a great exercise for several reasons. First off, they work your chest and shoulder muscles in a coordinated and functional way. And second, the core stability required to avoid letting your hips sag to the ground means you get the added benefits of core training in the same exercise.

You can make pushups easier by placing your hands on an elevated surface. Conversely, you can increase the difficulty by elevating your feet or moving your hands closer together.

Some variation of a deadlift is a must when it comes to staying fit. Standard barbell deadlifts and Romanian deadlifts are both popular options. You can also use dumbbells or kettlebells as your resistance.

To perform a standard deadlift, begin with your knees and hips bent and your chest at a 40 to a 45-degree angle relative to the floor. Drive through the floor with both feet to lift the weight until your hips and knees are locked out.

For Romanian deadlifts, begin with a slight bend in the knees, then hinge forward at the waist to reach the barbell. Romanian deadlift variations hit the hamstrings and glutes more, while standard deadlifts shift more load to the quads.

RELATED: 5 Exercises for Men To Increase Testosterone

Overhead pressing is a must for maintaining upper body strength and mobility. Everything from reaching for tools to screwing in lightbulbs requires you to be able to reach overhead and exert some force.

You can use barbells, dumbbells, or kettlebells to overhead press. When pressing, do not allow your shoulders to shrug, and always press the weight to full lockout.

Rows are movements that involve horizontal pulling and hit the major muscle groups in your upper back and biceps. My favorite rowing exercise is the bent-over single-arm dumbbell row. You can perform the same lift with a kettlebell. Additionally, you can perform bent-over barbell rows to hit both sides at once.

Regardless of your rowing exercise choice, avoid letting your shoulders shrug, and focus on "squeezing" your shoulder blades together as you finish the row.

RELATED: The 4 Best Quad Exercises for Men To Build Muscle & Strength

Lunges are an excellent functional exercise for your lower body. They mimic the standard gait and help improve balance, coordination, and athleticism alongside strength and muscle building. I prefer dumbbell lunges with the dumbbells held at your side. You can perform kettlebell lunges as well, or even rack a barbell across your upper back.6254a4d1642c605c54bf1cab17d50f1e

When lunging, take a deep step forward, and then lower your back knee toward the ground as you bend your front leg. Push through the floor to either step back to the starting position if lunging in place, or take your next step with the opposite leg if performing walking lunges.

Incorporating some form of rotational core exercise is important to keep your core strong and your spine healthy as you age. I like standing cable rotations if the equipment is available. However, Russian twists, medicine ball twists, or resistance band rotations are also great options.

Whichever twist variation you choose, do not round your spine when rotating. Begin in a neutral spine position, and rotate through your hips and torso to perform each rotation. Repeat on both sides.

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8 Exercises for Men To Stay Fit After 50 - Eat This, Not That


Mar 29

Fitness Concept Sweat440 Marks Grand Opening of Coral Springs Location Coral Springs Talk – Coral Springs Talk

By Ryan Yousefi

The grand opening of a new state-of-the-art fitness center in Coral Springs is on April 8.

The new fitness center, Sweat440, located at 6206 West Sample Road, says its designed for beginners and experienced fitness enthusiasts, offering dynamic 40-minute HIIT and cross-training classes that begin every 10 minutes.

Founded by Cody Patrick and Matt Miller, two personal trainers in Miami, Sweat440 aims to provide a convenient way for individuals at all levels of experience from beginners to fitness experts to exercise practically and efficiently on their own terms.

The grand opening event will mark the studios opening of its full schedule in the week leading up to it, from April 1 to April 8.

The door-opening celebration event will include an opportunity to take advantage of limited-time offers, local vendor offerings, and the chance to come and catch a 40-minute sweat session with the new neighborhood studio.

According to Sweat440 franchise co-owner Sam Simpson, the team behind its Coral Springs location is especially experienced and ready to energize the city with its fitness programs.

We have all been in fitness our entire careers, and we were very excited about the concept of Sweat440, Simpson told Coral Springs Talk.

We love the flexible scheduling and the effective programming Sweat440 provides its members and jumped at the opportunity to expand this brand in Coral Springs. All of us live in South Florida, scattered between the Miami and Fort Lauderdale area.

Sweat440 first burst on the South Florida scene with a location in Miami Beachs Sunset Harbour neighborhood and has since expanded the franchise to other sites in Doral, Brickell, Coral Gables, Deerfield Beach, Miami Lakes, Texas, New Jersey, Canada, and now, Coral Springs.

Simpson says once Sweat440 founders had a chance to get to know the Coral Springs area, it was an instant fit for a new location.

When we had the pleasure of spending time in this beautiful city, we instantly connected with the people and the small businesses, and we thought Coral Springs would be a perfect community to serve. Were proud to be a part of the neighborhood!

SWEAT440 is known for its state-of-the-art facilities that feature top-tier equipment and amenities designed to help members feel and see results. Experienced instructors and certified trainers lead each class.

In addition to the workout classes, members can enjoy exclusive access to in-studio fitness boutiques featuring the ultimate workout gear curated for every season.

As part of the grand opening celebration, Simpson says Coral Springs locals can take advantage of discounts until April 8, and everyone is welcome to their first class for free.

Our most exciting offer leading up to the grand opening is our Founders Rate unlimited membership, Simpson told Coral Springs Talk.

On the day of our grand opening, the full price for an Unlimited Monthly membership will be $149, but before April 8, our founding members can claim a lifetime price of $99/ month + 1 week free!

Smith tells Coral Springs Talk Founders memberships can be reserved through this link before the deadline.

Send Your News to Coral Springs #1 Award-Winning News Site Here. Dont miss reading Parkland Talk, Tamarac Talk, Coconut Creek Talk, and Margate Talk.

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Fitness Concept Sweat440 Marks Grand Opening of Coral Springs Location Coral Springs Talk - Coral Springs Talk


Mar 29

Bailey County Senior Center: Where all who enter as guests leave … – Muleshoejournal

The Bailey County Senior Citizens Center provides community services for the seniors in the area. In addition to organizing a strong retired and volunteer program, the center hosts a variety of games, exercise programs, language lessons, art classes, weekly lunches, and activities designed to keep individuals active and involved.

In addition to the many activities the Muleshoe Center has to offer, it provides free exercise equipment, pool tables, games such as dominoes, Yahtzee, etc. and Wi-Fi access. The center also supplies many low and affordable rental fees.

Other events that have been held at the center includes dances, family reunions, school reunions, 4th of July parade & activities, auctions, Veterans Appreciation Day, birthday celebrations, and yes, even a funeral was held inside the building.

In fact, my husband Royce Turner and I were the first to hold our wedding at the center. The building was decorated beautifully and packed with family and friends. At the time Royce was the Board President at the center and I was the Director there. The wedding proved to be a big success.

Things were going so well until Covid reared its ugly head. We had to close our center temporarily. We ended up losing many of our seniors to the pandemic. We are still struggling to get our center up and running again. But we havent given up. We are diligently working to get our center back to where it used to be.

Unfortunately, our numbers in attendance are way down and money is needed. New personnel and a new board has been put into place. Royce and I have agreed to work with the new board members in planning new events and fundraisers.

As part of this effort, I have agreed to visit with our present members and get ideas on what needs to be done to improve our efforts. Here are some of their responses:

Shirley White told me that there are senior citizens here in Muleshoe who are unaware of what we do at our center. She suggested we do more advertising or invitations to get those people involved. Shirley comes to our center every day to exercise. We have an exercise section with tread mills, rowing machines, weights, etc. There is no charge to use the exercise equipment. Like so many of us, Shirley wants to see our membership grow and prosper.

Marilyn Wilson Nickels is another member at our center. Marilyns health makes her unable to cook so she comes every day to get a good healthy meal. I come to enjoy the fellowship and the food, she told me.

Shug McCamish comes to our center 4 to 5 days per week. Shug lives alone so she enjoys just getting out and being with friends. She enjoys visiting with everyone at the center. She loves to play 80 and she was one of the first Presidents when the center first opened.

Our oldest member, Ruby Green tries to make it every day. Ruby is 103 years old and says she hopes to be there for many more years. Ruby said that she enjoys most of the activities and crafts held at the center. She says she will keep coming every day except those days when the West Texas wind blows.

Nina Landers is another one of our members who comes everyday she can. When asked why she comes to our center she responded, Why it beats the heck out of cooking at home. Nina told me that she hasnt found anything at our center that she doesnt like. She went on to say, Everyone here is like family. We support each other, have a great time, and come back the next day for more!

Mark and Marge Pilman moved to Muleshoe from Wisconsin. They come to our center almost every day. Mark suggested that we bring Bingo back as we did before Covid. Another idea he had was to get paper placemats on the tables and work with the businesses to place a discounted coupon on the mats. This way, the center members will use the coupons and the business will get advertising for their place of work. Mark and Marge said they come to the center just to watch, talk to people, and be a part of the games and events.

Ray and Jeanetta Precure have been coming to our center for over 20 years. Jeanetta said that she would love to see a planned exercise program done 2 or 3 days a week for anyone who is interested. Ray & Jeanetta both said they love to play dominoes every day. Ray & Jeanetta are also good at working and repairing things at the center. We had a vibrating machine to malfunction one day. I commented to them that it was my favorite work-out machine. The very next day Ray and Jeanetta tore the machine apart and then put it back together. I have used that machine every day at my 8:00 am exercise work-out. It is still working and I will forever be thankful to them for getting it done.

Doroteo Barron comes quite regularly to our center. He told me that he didnt participate in a lot of the activities but he thoroughly enjoys the meals. His friend, Tony Chacon agreed with him that the food is always good. And it must be. Tony drives all the way from Earth to visit and enjoy the meals.

Gail Gladden told me that she has invited some of the widows to come and get involved. She said that she loves the entertainment. However, sometimes its a little too loud for those who want to visit. She also said that she likes the days that Ann Johnson entertains us playing the piano.

Marcha Rasco had some good comments about the lunch meals. She also likes to participate in the activities each day. She did say that she would like to see the time changed when it comes to the activities. Rather than late afternoon, she would prefer them starting right after lunch which is 1:00 pm.

One of our newest members is Rosie Blanchard. Rosie moved here from California a year and a half ago. Her husband passed away, but before his death, he told her to go to the Bailey County Senior Center and check it out. She did just that. After her husbands death, the center became her refuge. She comes every day now that she can and enjoys it thoroughly.

These twelve people that we presented to you were chosen randomly. Some are in their 60s. Some in their 70s & 80s. A few others are in their 90s. Again, Mrs. Ruby is our oldest at 103. These individuals are all learning to put the past behind them, put the future in proper perspective and live each day at our center as it might be their last. They are keeping active, getting involved, and they all agreed that the Bailey County Senior Citizens Center is exactly where they need to be!

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Bailey County Senior Center: Where all who enter as guests leave ... - Muleshoejournal


Mar 29

Zealand Pharma Increases its Share Capital as a Consequence of Exercise of Employee Warrants – Yahoo Finance

Zealand Pharma

Company announcement No. 8 / 2023

Zealand Pharma Increases its Share Capital as a Consequence of Exercise of Employee Warrants

Copenhagen, Denmark, March 28, 2023 Zealand Pharma A/S (Zealand) (NASDAQ: ZEAL) (CVR-no. 20 04 50 78), a Copenhagen-based biotechnology company focused on the discovery and development of innovative peptide-based medicines, has increased its share capital by a nominal amount of DKK 34,594 divided into 34,594 new shares with a nominal value of DKK 1 each. The increase is a consequence of the exercise of warrants granted under several of Zealand Pharma's employee warrant programs.

Employee warrant programs are part of Zealand Pharmas incentive scheme, and each warrant gives the owner the right to subscribe for one new Zealand Pharma share at a prespecified price, the exercise price, in specific predefined time periods before expiration. For a more detailed description of Zealand Pharmas warrant programs, see the companys Articles of Association, which are available on the website: http://www.zealandpharma.com.

The exercise price was DKK 100.80 per share for 14,185 of the new shares and DKK 127.00 per share for 20,409 of the new shares. The total proceeds to Zealand from the capital increase amount to DKK 4,021,791.

The new shares give rights to dividend and other rights from the time of the warrant holder's exercise notice. Each new share carries one vote at Zealand Pharmas general meetings. Zealand Pharma has only one class of shares.

The new shares will be listed on Nasdaq Copenhagen after registration of the capital increase with the Danish Business Authority. Following registration of the new shares, the share capital of Zealand Pharma will be nominal DKK 52,003,057 divided into 52,003,057 shares with a nominal value of DKK 1 each.

A full copy of the amended Articles of Association can be found at https://www.zealandpharma.com once registered with the Danish Business Authority.

# # #

About Zealand Pharma A/S

Zealand Pharma A/S (Nasdaq: ZEAL) ("Zealand") is a biotechnology company focused on the discovery and development of peptide-based medicines. More than 10 drug candidates invented by Zealand have advanced into clinical development, of which two have reached the market and three candidates are in late-stage development. The company has development and partnerships with a number of blue-chip pharma companies as well as commercial partnerships for its marketed products.

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Zealand was founded in 1998 and is headquartered in Copenhagen, Denmark, with a presence in the U.S. that includes Boston. For more information about Zealands business and activities, please visitwww.zealandpharma.com.

Forward-Looking Statement

The above information contains forward-looking statements that provide Zealand Pharmas expectations or forecasts of future events. Such forward-looking statements are subject to risks, uncertainties and inaccurate assumptions, which may cause actual results to differ materially from expectations set forth herein and may cause any or all of such forward-looking statements to be incorrect. If any or all of such forward-looking statements prove to be incorrect, our actual results could differ materially and adversely from those anticipated or implied by such statements. All such forward-looking statements speak only as of the date of this release and are based on information available to Zealand Pharma as of the date of this release. Except as required by law, the Company assumes no obligation to update these forward-looking statements publicly.

Contact:

Anna Krassowska, PhDVice President, Investor Relations & Corporate CommunicationsZealand PharmaEmail: ank@zealandpharma.com

Link:
Zealand Pharma Increases its Share Capital as a Consequence of Exercise of Employee Warrants - Yahoo Finance


Mar 29

Wellness at the U @theU – @theU

Wellness takes many forms. It is present in exercise programs, diet and nutrition, mental health and preventative health measures. The Osher Center for Integrative Healths mission is to advance personal and professional wellness among campus and hospitals and clinics employees by providing full access to all the wellness tools they need.

WellUis the way most employees currently interface with the center. Program participants receive a discount on their health insurance premiums if they meet certain requirements by attending health screenings and various wellness activities. WellU also pays for or subsidizes various health activities on campuslike consultations with health coaches, nutrition workshops, diabetes prevention programs and mindfulness courses.

Offerings from the center go far beyond WellU though. For individuals, there are dozens of programs to help improve overall health and wellness in a variety of ways. If you want to make a change in your life you can most likely find help through the center. There are employee fitness classes, smoking cessation workshops, mental health evaluations, counseling opportunities, health testing programs and more.

The Wellness Ambassador Program aims to give employees an opportunity to improve their health while encouraging others to do the same. Ambassadors are trained on all the programs offered by the center so they can support employees in their wellness goals. They also provide feedback on current programs and how wellness offerings throughout the U could be strengthened and improved.

The center also offers programs for office groups that want to improve their overall wellness. Wellness Seed Grants awards funding to be used on a wellness-oriented improvement within a workspace, such as providing access to respite spaces, installing readily available water fountains or stocking their work areas with healthy snacks.

You can learn more about the offerings from Osher Center for Integrative Health here.

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Wellness at the U @theU - @theU


Mar 29

"#LikeAGirl" Program Encourages Athletics and Empowerment for … – Hillsborough County

Westchase Recreation Center after-school program partners with USF to teach girls self-esteem through sports

"Do not give up. Your mind will tell you it's hard, but do not give up. There's only wins and lessons. There are no losses." This was the advice that Ragan Kinard gave a group of young girls during her visit to an after-school program at the Westchase Recreation Center.

Kinard is a junior at the University of South Florida where she plays on the women's volleyball team. She was invited to speak with students about her experience as a female athlete, as well as give a volleyball demonstration. Her visit, coordinated through the "#LikeAGirl program," was a hit with the kids.

Ragan Kinard takes questions from students in the "#LikeAGirl" after-school program

"#LikeAGirl"Karlie Mintzer, Recreation Assistant Supervisor at the Westchase Park & Recreation Center, was organizing a kid's game of soccer for an after-school program when the idea came to her. After the children had picked their teams, she had found that the best player that day was chosen last.

Mintzer was told by a little boy that it was because the player was a girl. It was at that moment Mintzer realized the need for a special sports program just for young women.

"#LikeAGirl" was developed through a partnership with the Hillsborough County after-school program and the University of South Florida. Once a week, a female collegiate athlete from a different sport visits the recreation center and gives a presentation. Each session begins with the visiting athlete introducing herself and taking preplanned questions from the kids. The conversation gives the young girls a chance to practice speaking in front of a group, as well as gain insight into the world of women's sports.

Following the question-and-answer portion of the program, the visiting athlete delivers a sports demonstration. The girls learn pointers on how to play specific games, as well as practice newly learned techniques. After the physical activity, the girls participate in a team-building exercise. Topics such as how to be a better teammate and friend are taught, then discussed as a group.

Ragan Kinard, USF volleyball player, teaches volley techniques to students in the "#LikeAGirl" after-school program

Volleyballin' like a girlIt was clear that Kinard made a strong impression on the girls. Her session with the students was filled with more questions then they had time for. The kids were intensely engaged in learning about Kinard's experience on her volleyball team and how she was recruited in high school to play for USF. By the look on some of their young faces, you could tell the girls were in awe.

Before showing the group how to volley, Kinard was served a slew of questions from the curious girls. Everything from beach volleyball and her height to what career Kinard wanted was discussed.

One young student asked Kinard, "What's the worst part about being a girl in sports?"

Without missing a beat, Kinard answered with a smile. "Nothing."

The Westchase Park & Recreation Centeris located at 9791 Westchase Dr., Tampa, FL 33626. Call (813) 744-5978 or email recreation_admin@hcflgov.net for more information about Hillsborough County after school programs.

Photo Information: Ragan Kinard, USF volleyball player, teaches volley techniques to students in the "#LikeAGirl" after-school program.

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Mar 29

Personalized diet intervention in Thai ageing populations – Open Access Government

Thailand has rapidly become an ageing society, and the average age of the Thais will be 30 years older compared to 1975. As the elderly population increases, it is anticipated that there will be more incidences of non-communicable diseases (NCDs) such as obesity (OB), diabetes (T2D), and cardiovascular disease (CVD).

Notably, the prevalence of T2D has increased rapidly from 6.5% in 2015 to 10.7% in 2030 (estimated), with the most significant increase will be found among the elderly population (72%). In developing countries, NCD has become the most immense burden among the poor elderly whose life depends on their children. There are strong links between consuming high glycemic index foods, a sedentary lifestyle, and NCDs. So, developing lower glycemic index meals and changing lifestyles with diet intervention programmes are sensible solutions to slow down the prevalence of future NCDs.

In order to understand the impact of redesigned meals on NCDs among adults. The metabolic cohort (MBC) comprised 146 participants, including 24 % adult males aged between 37 and 60, following the screening of biomarkers, gut microbiota, fat mass, MRI-scanned visceral fat, and hepatic fat. The MBC was subdivided into obesity (OB), type-2 diabetes (T2D), cardiovascular disease (CVD), and chronic kidney diseases. To monitor the benefits of diet intervention, the MBC was served for three months of diet intervention and exercise programs compared to the no-intervention group. Tracking for the progress in biomarkers, body weight (BW), body mass index (BMI), gut microbiota, fat mass (FM), visceral fat (VF), hepatic fat (HF), and daily food records after 3 and 12 months at Siriraj Hospital, Bangkok, following the exercise and diet intervention programs compared to non-intervention (Figure 1).

Redesigned from popular local dishes, personalised diet recipes were developed to meet medical restrictions, BW, BMI, food allergies, food restrictions, gender, age, and occupation. Because rice largely contributes more than 50% of energy in daily rice-based meals among Thais, a new mixture of intermediate to low glycemic index rice varieties were invented to control total daily energy targets of personalised diet intervention plans. We developed 3G rice, a three-way mixture of two soft-cooked whole grain intermediate GI rice varieties, the famous purple Riceberry, aromatic brown Hom Maliman, and the low GI Pink+4, fragrant white rice with high amylose content. The effects of 3G rice were compared with regular white rice (Figure 2).

Twenty-nine recipes were successfully designed to meet personalised, targeted total daily energy from 1000, 1200, 1500, 1800, and 2000 kcal (Figure 3). The medical restrictions were laid out by doctors and dietitians to limit the amount of sugar, sodium, and fat, including trans-fat, saturated fatty acids, and protein. Meal plans contained carbohydrates: protein: and fat equal to 45-50:20-30:20-30, respectively. Also, Na, Ca, K, and P were controlled at <2,000 mg, <1,200 mg, <2,800-4,500 mg, and <800 mg, respectively. To avoid repetitiveness, different menus within each category of medical restriction were rotated weekly by participants. The 3G mixed rice and well-designed meals were freshly made daily for early-morning home delivery to all patients for three months. Daily food consumption and exercise practices were recorded throughout. Participants were satisfied with the taste and nutritional quality of 3G rice-based meals. Exercise therapy for ageing patients Pliability, a new exercise program, was designed for the elderly to optimise muscle strength and flexibility by walking for at least 6,000 7,000 steps `daily with aerobic exercise programs. The MBC participants were grouped based on their BMIs into three degrees of obesity OB1, OB2, and OB3 for BMI 23-24.9, BMI 25-29.90, and BMI > 30, respectively. All participants were recommended 20-30 minutes of aerobic exercise and pliable programs designed for each OB group. The exercise therapy was monitored daily via a smartwatch for 1, 3, 6, and 12 months. The outcomes varied by the OB groups. The number of days required to reduce BMI to 23, the regular scale, is monitored for each group. For OB1, 70% of participants reached the normal BMI by 45 days, while OB3 required 180 days. In the worst case, 20% of participants needed 300 days to get a BMI of 23.

Compared with a regular diet, diet intervention was associated with a more significant reduction in BW, BWI, VF, and HF among adult cohorts. Nonetheless, patients who received new exercise intervention had fewer effects on BMI, VF, and HF but no difference in BW compared with routine exercise.

Stools collected from MBC members were analysed for predominant microbial communities leading to a selection of high potency and disease- specific probiotics and providing precision diagnosis and treatment of different NCDs. Currently, 90 microbial isolates were identified from the stools collected from T2D and OB patients. Most of the microbial strains were coccus and rod-shaped, gram-positive bacteria. The identification of isolated gut microbiota will be accomplished using metagenomic sequencing. Furthermore, the hemolysis analysis of isolated gut microbiota between OB and T2D revealed exciting outcomes.

On the one hand, the gut microbiota isolated from OB contained 53:42:5 for Gamma: Beta: Alpha hemolytic bacteria. On the other hand, the isolated microbiota from T2D had 82:16:2 for Beta: Gamma: Alpha hemolytic bacteria. That is another exciting outcome from specific gut microbiota isolated from MBCs OB and T2D patients.

This on-going project has been financially supported by the National Research Council of Thailand (NRCT).

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Personalized diet intervention in Thai ageing populations - Open Access Government


Mar 29

4-H food, nutrition programs use MyPlate test to lead to healthier you – Wooster Daily Record

Laurie Sidle| Wayne County Extension

Make good choices.

Its a favorite piece of advice teachers give their students. It also works well for deciding what foods we eat and how much exercise we fit into our schedule.

National Nutrition Month, celebrated in March, stresses the importance of a balanced diet and exercise. In its 50th year, the campaign created by the Academy of Nutrition and Dietetics, helps families focus on healthy eating by encouraging them to try new fruits and vegetables and explore new ways to enhance flavors in food with herbs and spices or citrus fruit like lemon or lime.

Other recommendations by the academy include:

In the 4-H program, a variety of food and nutrition projects empower youth to be healthy mind and body with skills to make healthy decisions and lead healthy lifestyles. The projects help members develop knowledge, skills and understanding of nutrition, menu planning, safe food handling, fitness, meal & time management, and food & nutrition-related careers.

All 4-H food and nutrition projects use MyPlate, the U.S. Department of Agricultures official symbol of the five food groups. The colorful divided plate includes sections for vegetables, fruits, grains, and protein foods.

Vegetables and fruits should take up half the plate and grains and protein foods each take up a quarter of the plate. A side helping of dairy is a reminder to include milk or another dairy food like cheese or yogurt in your daily meal plan.

Choose MyPlate for A Healthier You is an opening activity in the Everyday Food and Fitness 4-H project. Members are asked to take a closer look at their food choices based on MyPlate by recording what they eat throughout the day. Are they eating a variety of foods from each food group? Do they choose foods and beverages that are low in fat, sodium, and added sugars?

The project follows MyPlate advice to start simple. The benefits of healthy eating add up over time, bite by bite. Small changes matter. A healthy eating routine is important at every stage of life. It can have positive effects that add up over time.

Also, choose options that are full of nutrients. Eating foods that are packed with nutrients instead of empty calories makes you feel full and satisfied after meals.

In the Everyday Food and Fitness project, the member becomes a grain detective to figure out which foods fall in the grain group and what the label says about the content of whole grain. The project also asks the 4-Her to:

Other projects focus on different aspects of nutrition. Snack Attack! features activities and related recipes for healthful snacks; Take a Break for Breakfast focuses on starting the day with a nutritious breakfast; Sports Nutrition: Ready, Set, Go deals with eating well and exercising; and Racing the Clock to Awesome Meals focuses on the knowledge and skills needed to prepare quick, nutritious, low-cost meals.

4-Hers have a wealth of opportunities to explore nutrition and fitness. Lets join them in creating our own healthy habits. If you are interested in joining 4-H, contact our office before the April 1 deadline at 330-264-8722.

Laurie Sidle is an OSU Extension Family & Consumer Sciences program assistant and may be reached at 330-264-8722 or sidle.31@osu.edu.

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4-H food, nutrition programs use MyPlate test to lead to healthier you - Wooster Daily Record



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