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Novel research by investigators at the Desai Sethi Urology Institute (DSUI) at the University of Miami Miller School of Medicine was presented at one of the world's most important urology meetings and simultaneously published in one of the highest impact journals in the specialty.

This reflects the quality of research at the DSUI, as this is the first time the Journal of Urology earmarked and simultaneously published American Urological Association (AUA) annual meeting presentations, according to Ranjith Ramasamy, M.D., director of reproductive urology at DSUI.

Two studies, one on a type of short-acting testosterone therapy and another looking at whether platelet-rich plasma (PRP) works to treat erectile dysfunction (ED), were presented during the April 28 to May 1 AUA 2023 meeting in Chicago and published online the day of each presentation in the Journal of Urology.

"These were randomized clinical trials, which offer the best evidence but also are the most challenging and arduous to conduct," Dr. Ramasamy said. "They reflect the primary focus of the DSUI, which is to conduct investigator-initiated clinical trials."

These studies also offer new information for clinicians and patients on common approaches used to treat common conditions, according to Thomas Masterson, M.D., assistant professor of urology.

Traditional treatments for erectile dysfunction focus on pathways that treat ED symptoms without reversing underlying ED causes. The most popular restorative therapies today are shockwave therapy, platelet-rich plasma and stem cell therapy. Restorative therapies have the potential to reverse the underlying pathology of ED.

"All three of these are not FDA approved for ED, and there is not a lot of good research on them," said Dr. Masterson, who was the author of the study.

"While some small studies have shown potential benefits for platelet-rich plasma, popularly called the "P-shot," larger and more rigorous clinical trials are needed to fully evaluate the efficacy and safety of platelet-rich plasma therapy for erectile dysfunction," said Dr. Manuel Molina, a men's health fellow and sub-investigator in the clinical trial.

DSUI investigators are the first to show using PRP was no better than using placebo to treat ED patients.

"This finding may prompt health care providers to reconsider the use of platelet-rich plasma therapy as a viable treatment option for erectile dysfunction until further research provides more conclusive evidence," said Braian Ledesma, a student and study coordinator. Ledesma presented this finding as a late-breaking abstract at the AUA annual meeting.

Patients need to be informed consumers, according to Dr. Masterson.

"This study is the first negative study suggesting PRP, which can be very expensive, may not be any better than a placebo," he said.

There are several forms of testosterone therapy, including those that are injected intramuscularly or subcutaneously, applied to the skin or taken orally as pills, as well as intranasal gel, which is applied on and absorbed into the nasal mucosa.

"Traditional forms of testosterone therapy are known to increase hematocrit, which is the percentage of red blood cells in your blood. That could lead to a risk of cardiovascular events, like heart attacks, blood clots or stroke," said Marco-Jose Rivero, an author on the study and a Miami Andrology Research Scholar at DSUI. "Our objective for this trial was to evaluate and compare intramuscular testosterone therapy versus intranasal testosterone gel, with regards to whether or not they increase hematocrit."

This is the first head-to-head study comparing the two, according to Dr. Ramasamy. Men were randomized to receive either intramuscular testosterone, which is administered every two weeks by injection, or the nasal gel, which is applied two to three times daily.

The researchers found that intramuscular testosterone does increase hematocrit levels, while intranasal testosterone gel does not. And intranasal testosterone gel may be a better option for patients with cardiovascular risk factors and others who want to avoid the potential side effect, according to Rivero.

"This finding is important because we do believe the increased red blood cell count or hematocrit is what puts people at risk of cardiovascular or thrombotic events," said Russell Saltzman, the clinical trial coordinator.

Rivero, a medical student, said that his working on such an impactful randomized clinical trial has allowed him to gain research experience in a rigorous study design, while also further developing his ability to care for patients.

"I am grateful for the opportunity to share my findings with a national audience, through both a poster presentation at the AUA and a publication in the Journal of Urology," Rivero said.

More information:Marco-Jose Rivero et al, Comparison of Hematocrit Change in Testosterone-Deficient Men Treated With Intranasal Testosterone Gel vs Intramuscular Testosterone Cypionate: A Randomized Clinical Trial, Journal of Urology (2023). DOI: 10.1097/JU.0000000000003487

Thomas A. Masterson et al, Platelet-rich Plasma for the Treatment of Erectile Dysfunction: A Prospective, Randomized, Double-blind, Placebo-controlled Clinical Trial, Journal of Urology (2023). DOI: 10.1097/JU.0000000000003481

Provided by University of Miami Health System, Miller School of Medicine

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Clinical trials simultaneously presented at AUA and published in ... - Science X

JME and his special guest mates played a relentless set at Bristols Motion, as part of the Boy Better Know co-founders Grime MC FM event series. Whilst grime prides itself on intensity, with no let-ups, the show was only really ever in one gear.

When Drake made a guest appearance at a Section Boyz gig back in 2016, shortly before announcing hed signed to Skepta and JMEs Boy Better Know collective, UK grime had reached a new apex. Even at its most cynical level, the Canadian superstar saw the scene as a gateway toward earning UK cultural kudos.

Yet as with all genres, grime has faced a constant push-and-pull between preserving its core tenets and splintering off into something new. In this instance, the rise of drill (which first emerged in Chicago) has been taken up to give hard-hitting depictions of inner-city life, whilst a more melodious UK rap scene has emerged, no better represented than by Knucks sublime Alpha Place.

JME is still delivering on the same tried and tested grime formula he knows, spitting fast bars over 140bpm garage and jungle influenced basslines. Given the success its brought him, you could hardly blame him.

But at Bristols much-loved Motion this weekend, this often grew wearisome. JME Presents Grime MC FM was a blazing bank holiday bash no doubt, but with little space to breathe both in the set and the sweaty, gun-finger-toting crowd it became stuck in a not-too-distant past.

It would take an hour and a half for an MC to appear, with P Money taking over from a DJ setlist that had riffled through most of the grime classics. Asserting himself with Whos In Charge, P Money would later get the crowd featuring in a music video for his new track Bars n Dat.

This constant hype-athon would be the general gist of the night. The mini-fridge perched near the DJs turntable stacked full of the KSI-endorsed Prime drink tells you all you need to know: this event was all about in-your-face energy.

P Money promised the crowd the night would be grime in its purest element and by the time JME did arrive, flanked one at time by special guests, his words certainly came true.

The premise of JMEs Grime MC FM a pirate radio-styled live show built off the back of his 2020 album Grime MC is that its special guests remain a secret until the day. For Bristols entertainment, the list of MCs included Manga Saint Hilare, Tempa T, Shorty, Blay Vision and Flirta D.

Spitting in turns under red lights and a simple Grime MC FM banner, Manga Saint Hilare achieved the most wheel ups (by my reckoning anyhow), whilst Flirta D gave the most memorable moment when he interpolated parts of his Cammy Riddim Freestyle into the set.

The sheer stamina and persistence of the night was impressive, but overall the non-stop bars even for a genre that prides itself on building tracks around a repeated phrase became tedious. This was perhaps most evidenced, too, by the indecisive mosh pits, which ballooned out only to fall in on themselves indecisively when there was no clear drop.

JME left Bristol by previewing something exclusive. In reality, it sounded like a lot that had come before. As he went to biggup the MCs, the DJs, you could certainly admire the Grime MC FM idea, for trying to keep the underground spirit where grime was forged alive.

Grime is by no means dead, but this event did make you wonder whether its now so far removed from the underground that its become a pastiche of its former glory; a victim of its own success, which Drake, for better or worse, has long-since moved on from.

Read more:
JME at Motion review | Testosterone-fuelled tribute to times gone by - whynow

While the question of transgender and DSD athlete participation in female sporting competitions is undeniably controversial, the history of athletics regulations in the last decade has demonstrated the importance of providing evidence and justification for eligibility restrictions.

On 24 March 2023, the World Athletics Council (WAC) (previously the International Association of Athletics Federations or IAAF) announced new regulations for transgender athletes or athletes with a Difference of Sexual Development (DSD) (2023 Regulations). These regulations directly impact the eligibility of these athletes to compete in the female category at the international level.

In sum, the WAC:

The decision marks the latest stage in attempts to regulate access to the female category of sporting competition. The last decade or so has seen a particularly contentious debate emerge over regulation of the participation of athletes by reference to testosterone levels, with the Court of Arbitration for Sport (CAS) suspending previous regulations for lack of evidence of an advantage.

As it is unclear on what scientific basis the WAC has made this most recent decision, there is a real question as to whether the 2023 Regulations are similarly vulnerable to challenge by transgender or DSD athletes.

An evolving position

Gatekeeping of the female category can be traced to the beginning of regulated female sport, with the use of testosterone levels as a metric for assessing eligibility a relatively recent development.

Recent history has seen the identification of testosterone as a basis for eligibility, with threshold requirements initially set at 10 nmol/L:

The development of these guidelines provided the basis of what appeared to be an emerging consensus on testosterone levels as an indicator of advantage for transgender and DSD athletes, and as something that should be controlled to ensure a fair competition. However, there has also been a more recent trend towards total bans on male-to-female transgender athletes who have experienced male puberty, as evidenced by the 2023 Regulations released by the WAC. Other bodies that have introduced similar rules include World Aquatics (formerly FINA) and World Rugby, and have cited concerns about unfair advantage and the potential for transgender women to cause serious injuries to cisgender women. Some commentators have questioned the availability of scientific evidence to such policies, stating that "at present, no data suggests safety in women's sport is compromised by including trans women".

By contrast, some domestic codes have sought to develop policies to facilitate the inclusion of transgender and gender-diverse athletes in elite sport. For example, the Football Federation of Australia has announced its commitment to supporting the inclusion of transgender and gender-diverse people in football through the development of a High-Performance Inclusion Policy. The Australian Football League has also sought to codify when a male-to-female transgender athlete may be eligible to participate in the AFLW (although that policy appears, at least. questionable in terms of the metrics used to assess eligibility).

Challenging the consensus

In 2014, Indian sprinter Dutee Chand was subjected to a "gender verification" test by the Athletics Federation of India, after questions were raised about her physique and impressive competition performance. The test identified Chand as having testosterone levels above the 10nml/L level set by the IAAF 2011 Regulations and being an athlete with a DSD. As such, she was deemed ineligible to compete.

Chand challenged the IAAF 2011 Regulations at CAS. In 2015, CAS determined that there was insufficient scientific evidence supporting a link between enhanced testosterone levels and improved athletic performance, and suspended the IAAF 2011 Regulations. The IAAF was given two years to produce relevant evidence, otherwise the IAAF 2011 Regulations were to be declared void.

In 2017, the IAAF produced a report that found elevated testosterone levels advantaged female athletes by margins of between 1.78% and 4.53% in middle distance running, hammer throw and pole vault. No impact was noted in any other competition or in any men's category events.

In 2018, off the back of this report, the IAAF issued new regulations (2018 IAAF Regulations). These stipulated that a DSD athlete was restricted from competing in middle distance (400m-1 mile) running events (Restricted Events) unless they had circulating testosterone levels of 5nmol/L or below and were able to maintain those levels for at least six months prior to competing (and continuously thereafter).

In 2019, Caster Semenya, a middle-distance runner from South Africa and DSD athlete, challenged the 2018 IAAF Regulations on the basis that they were discriminatory, not necessary, and not reasonable and not proportionate. Under the 2018 IAAF Regulations, Semenya was ineligible to compete in the Restricted Events without taking medication or undergoing surgery.

Unlike Chand, however, Semenya's challenge was unsuccessful. CAS upheld the 2018 IAAF Regulations, finding that they were discriminatory but necessary, reasonable and proportionate to achieve fair competition in the female category. Nevertheless, CAS questioned the strength of the evidence in respect of some of the proposed Restricted Events and suggested the IAAF consider withholding implementation of its regulations until further evidence could be obtained. The IAAF rejected this suggestion.

Semenya has sought to appeal this decision, first in the Federal Supreme Court of Switzerland (which was unsuccessful) and now in the European Court of Human Rights (decision pending).

Continuing paucity of evidence

The question of how transgender and DSD female athletes perform against cisgender, non-DSD female athletes has been the subject of increasing debate in recent years. However, that has not corresponded to significant scientific study of the question. As noted above, the IAAF itself declined CAS' recommendation to obtain additional evidence regarding the impact of elevated testosterone on athletic performance.

Perhaps most relevantly, a 2021 study in the British Journal of Sports Medicine suggests that transgender women maintain an athletic advantage over their cisgender peers even after a year of hormone therapy. The study found that prior to taking female hormones, trans women performed 31% more push-ups and 15% more sit-ups in one minute, and ran 1.5 miles 21% faster than their cisgender peers. After two years of hormone therapy, the push-up and sit-up differences disappeared, however the trans women were still 12% faster.

However, the study involved a sample size of only 46 transgender women and focussed on armed forces personnel, as opposed to athletes and sporting performance generally. As such, it is unclear how or whether the findings can be applied to particular sports, or whether the sample size is large enough to draw accurate and broadly applicable conclusions. Similar criticisms can also be raised over a 2019 Swedish study, which found that thigh muscle mass was reduced, albeit marginally, after 12 months of hormone treatment. However, this study followed just 11 transgender women and only assessed muscle mass in the thigh and knee.

As such, it is difficult to say that there is conclusive evidence of widespread or universal advantage resulting from elevated testosterone. Associate Professor Ada Cheung, an endocrinologist at Austin Health who also leads the Trans Health Research Group at the University of Melbourne, has said that when it comes to transgender health there is "not a lot of evidence, but plenty of assumptions". Cheung also says that "no long-term research with adequate comparison groups (adjusted for height) has examined the impact of hormone therapy on strength, fitness and endurance" and that, while larger stature is possibly an advantage for some sports, it's equally possible that a transgender women with a larger stature and smaller muscle mass may actually be at a disadvantage.

Viability of 2023 Regulations

The 2023 Regulations mark a significant shift in the regulation of female eligibility. Firstly, the regulations again lower the testosterone levels permitted, second, they apply to all events (and not just Restricted Events) and third, they exclude transgender athletes completely. A summary of the evolving regulations is illustrated in the table below.

For the past five years, restrictions on eligibility were limited to the Restricted Events, where evidence of an athletic advantage had been accepted by CAS. The absence of such evidence was the reason the 2011 IAAF Regulations were suspended and the 2018 IAAF Regulations were limited in scope.

In its press release of 24 March 2023, announcing the 2023 Regulations, the WAC said:

"World Athletics has more than ten years of research and evidence of the physical advantages that these athletes bring to the female category."

With no reports, studies or specific evidence cited, it's unclear what the WAC has relied to support the shift and, indeed, whether it has the evidence CAS may require.

In relation to the ban of transgender athletes, WAC has acknowledged that:

"there are currently no transgender athletes competing internationally in athletics and consequently no athletics specific evidence of the impact these athletes would have on the fairness of female competition in athletics."

However WAC noted that in the circumstances, it had decided to "prioritise fairness and the integrity of the female competition before inclusion".

The importance of evidence

While the question of transgender and DSD athlete participation in female sporting competitions is undeniably controversial, the history of athletics regulations in the last decade has demonstrated the importance of providing evidence and justification for eligibility restrictions.

It is critical to remember, as sporting federations grapple with the questions of fairness and inclusion when determining whether to allow transgender or DSD athletes to compete while emotive, such decisions need to be made by reference to available evidence, otherwise they are, and will remain, vulnerable to challenge.

Continued here:
Transgender athletes or athletes with a DSD: science and the need ... - Lexology

For actorHeather Mitchell, the #MeToo movement was a long time coming. When women started speaking out, "it immediately resonated,it really did shake me up", she says.

It sent her reflecting down the decades of her own life, all the times she had felt unsafe, uncomfortable and threatened, "not just in my industry, but throughout my life".

"It made me realise that I had minimised experiences," Mitchell tells Australian Story."I was shocked at how I had silenced myself."

There was an actor who was always drunk and took things "much further than was safe", she says. "I felt physically threatened by him and therefore psychologically frightened. But I didn't know anyone to speak to. I felt powerless."

In the 1980s and 90s, she remembers a lotof drugs and alcohol being consumed on some sets. "There were freedoms that were taken, I did feel very uncomfortable."

"The film sets and TV sets were very male dominated.I would go so far as to say very testosterone, cocaine and alcohol-fuelled places."

One time while resting in her van on a set with her eyes closed, she woke to find a man kneeling and kissing her "his tongue in my mouth" and another man watching.

"I did go to a producer and suggest that something should be done. To my knowledge, nothing was done about it.I didn't feel I had a voice," she says. "I was afraid to speak out."

The fear of losing a job or not working again proved all too true when she did make a complaint about another incident, only to be "written out of the show, pretty much".

After that, she retreated to the place she felt safest. "I threw myself into the theatre. I felt in the theatre there was much more of a camaraderie. There was much more of an equality, a feeling of family."

Now in her 60s, in her full power and doing some of the best work of her career,Mitchell is determined that what she lived through doesnot happen to the next generation.

"When I'm working with younger people, I certainly encourage them to speak up if there's anything they're uncomfortable about, and to know who to speak to," she says. "In terms of sexual and emotional safety, I think it's an ongoing discussion that has to just keep happening."

"Heather is a very powerful voice in our industry," says Sydney Theatre Company artistic director Kip Williams. "And she uses that power to advocate for other young women."

The great reckoning has led to the industry being in a much better place than it was five years ago, according to Mitchell. "Now you feel the impact and the input of incredible women, many more female producers, writers, better roles for women, stories about women," she says.

WhatMitchell did with those frightening situations was to "file them away". A part of her would "stand outside of it", she says, and observe. Later, she would draw on it in her acting.

Now, after four decades starring on Australians stages and screens, Mitchellbrings her whole life to her performances, a life that has been lived with love and passion, and one threatened by cancer too.

"She is able," her old friend and co-star Hugo Weaving says, "to tap into a deep well of love and grief, but at the same time being very light and very buoyant."

Last October, her portrayal of Ruth Bader Ginsburg (RBG), the late US Supreme Court judge, at the Sydney Theatre Company, was described by the Sydney Morning Herald as "a performance to live among the greats".

After a lifetime of supporting roles, Kip Williams says:"Here was this pinnacle of acting vehicles for Heather to really be showcased for the genius that she is."

Playwright Suzie Miller had written it specifically with Mitchell in mind. "It was so obvious that it had to be Heather," she says.

"There were so many things in Ruth's life that resonated with me," Mitchellsays. "I was brought up with a Jewish mother. My mother died on my last exam of school. So did her mother."

They even both married a man named Marty.

Performing as RBG, who had fought so hard for equality and the rights of women, gave Mitchell the confidence to write about her own life in her just-published memoir Everything and Nothing; to articulate her own experiences of abuse and inequality.

The one-woman play had been interrupted by her second diagnosis of breast cancer and finishing the season had been a physical and mental feat.

"I don't know how she did it," Williams says, "For Heather to bring that story to life just months after overcoming cancer was a once-in-a-lifetime thing. Heather went to this transcendent place."

Mitchell is a person friends describe as universally loved;a rememberer of birthdays, a bringer of cakes, "Heather will come to rehearsals having learned all her lines," Williams says, "and yet she will have baked three vegan cakes for the entire cast overnight."

Friend and filmmaker Jocelyn Moorhouse used to call her "Heather Angel". "She is just so gracious and ethereal," she says.

Mitchell has a "warmth and natural empathy", says close friend and former boyfriend Sam Neill, which translates into her work in a "really magical way. A lot of that comes from being a naturally good human being".

When they were both going through cancer last year, she, Neill and the artist Nicholas Harding formed a "cancer club".

Mitchell had T-shirts printed with"F**k off cancer" on them. "And we'd get together occasionally in our T-shirts and drink good wine and have a great time," she says.

Harding died last December. "We miss him terribly," she says.

When she was 11, her "joyous, smart" mother Shirley was diagnosed with leukaemia. "Back in the late 60s you didn't talk about cancer," Mitchellsays. "She kept it an absolute secret."

As her mother got weaker, Mitchell dealt with it by creating characters in her bedroom. They were "to prepare me for grief, for loss," she says. "I suppose I was doing my own therapy."

Shirley died when Mitchell was 17, during her trial exams for the Higher School Certificate. She left behind a letter, "just saying what a gift I'd been and how much she had loved being my mother".

Mitchell had been left "adrift" by her mother's death. But after enrolling at the National Institute of Dramatic Art (NIDA) performing arts school, she soon found her place in the world and her passion.

"I loved being there and I loved doing it," she says. "I loved every class. I didn't care if they were repetitive. I was in heaven."

She and Hugo Weaving were some of the early recruits to the burgeoning Sydney Theatre company.

Mitchell's first big-screen break was with Weaving in the 1983 TV series Bodyline, about "the" famous cricket clash between Australia and England in the 1930s.

But after it aired, she found it difficult to get auditions. For a time, she was living in her girlfriend's yellow Mini and doing house-sitting.

A casting agent stunned her by telling her she didn't have "it", "that elusive thing". Mitchell was shocked, but quickly learned that "in this industry, resilience is your best friend".

In 1989, Mitchell had to fly to Broken Hill on a last-minute job. The day before leaving she had been to a clairvoyant who told her she would meet "my guardian angel and it would make itself known to me".

She was picked up at the airport by cinematographer Martin McGrath. Three nights later, walking home from the pub, they had taken shelter from the rain under an awning. "And then," Martin says, "we just kissed. That was it, it was on."

When they moved in together, Mitchell says:"Every time I'd come back to where we lived, as I turned the corner, I thought, 'I'm going home.' Being with him was like being home." In 1992, they were married.

After six years of trying, at the age of 42, Mitchell had her first child, Finn.

Two years later, Seamus arrived. When he was five weeks old, Heather woke up to find him "boiling hot". He was critically ill with meningitis. "He was very lucky to live," Martin says.

There were distressing weeks in and out of hospital. "I don't think there is anything scarier than your child being in trouble," Mitchell says."It's the most frightening thing."

There were months of trying to work out the effects on his development, months of a screaming child.

"It really did have a huge impact on all of our lives," Mitchell says.

For three years, Mitchell had a lump on her breast. "My left hand travelled to it at least 10 times a day," she writes in her memoir. But she was told, after mammograms, that it was benign.

Still, she was worried that it was too high up for the mammogram to see and asked for an ultrasound. "And that was when I found out I had grade 3 breast cancer." She was 46.

After they had both cried, Mitchell, Martin says, "grabbed the lance and rode into battle like Joan of Arc. She's made of very, very tough stuff." There would be two years of gruelling surgery, chemotherapy, radiotherapy.

"The cancer really took her to within a whisper of life," close friend Joanne Corrigan says.

"She was skeletal. There was a day when I went over to visit her where I honestly thought, you know, this is the last time I'm going to be with my friend.

"And she just slowly and surely came back to life."

Mitchellwanted desperately to work during that time, but the jobs dried up altogether for both her and Martin.

"Basically, we seemed to be unemployable," Martin says. "I could see what was coming was like a slow-approaching train smash, that we really needed to sell the house and regroup. It was a very confronting time."

But in the middle of all that, they received an anonymous letter with a bank cheque for $30,000. The letter said:"I am writing to you because over the years I have so much enjoyed your performances. It gives me pleasure to say thank you in a tangible way to artists whose work I have admired."

They still don't know who sent it, but it was a "godsend" and kept them going for a year.

The Sydney Theatre company was about to announce the 2022 season last January, which included RBG:Of Many, One, when Mitchell received another cancer diagnosis. "The return that everyone dreads," Martin says.

It had been 17 years since the last diagnosis. This time it had been caught early and hadn't spread.

"It felt completely different," Mitchell says. "A little stumble, a trip and I straightened up again. I had a mastectomy with reconstruction. I was so thrilled I didn't have to do chemo."

And the second time around, cancer was not going to stop Mitchell. She had the surgery in March and was rehearsing three months later, as well as travelling to Melbourne for a role in the TV series Love Me.

"She never breaks into a sweat," Sam Neill says. "How is that possible? She's doing three things at once."

Neill watched her performance in RBG "with my jaw on the floor. At the end of it, I found myself not just on my feet, but in floods of tears. And I thought all those struggles, all those adversities, all the health issues, all the rest of it, paid off in a way that I could never have dreamt was possible".

Heather Mitchell doesn't fear ageing in the way some actresses do. "I love acting more than ever now. It's given me so much in my life and I just feel as I get older acting is about growing in your life. I love getting old because I love seeing my kids growing up. I feel so blessed that I've lived long enough to see them in their 20s."

Mitchelllives every day as if it is her first. "I can go for a walk in the morning and see things fresh and see new colours and talk to people and find something new in them."

Basically, she says, "getting old is fantastic".

Watch Australian Story's Taking the Lead onABC iview.

See the original post:
How Heather Mitchell stood into her power during the #MeToo movement - ABC News

They describe themselves as lifelong, liberal Democrats, but the makers of a documentary about the difficulties of people who transitioned from one gender to another and back have found themselves branded as bigots and anti-trans grifters as well as TERFsshort for Trans-Exclusionary Radical Feminists.

They said a screening of Affirmation Generation had been canceled due to pushback from trans rights activistsincluding threats of disruption and social media attacks, and another required extra security and a secret location. Some of the film's makers say they did not dare use their own names.

"If Hollywood knew I made this movie, I would be immediately canceled and destroyed," said producer Vera Lindner, who goes by a different name for mainstream projects.

With transgender issues among the hottest political topics in the U.S., the makers of Affirmation Generation accuse Hollywood and many media of not giving a platform to dissenting opinions.

The debate over trans rights encompasses everything from whether transgender women should be able to participate in women's sports to when gender should be discussed in school to drag performances in front of kids, but a central element is youth access to gender-affirming care such as hormone treatments and surgery.

While many doctors, as well as trans rights activists, say it is harmful for young people to be denied treatment that could reduce their distress or prevent suicide, opponents say confused youngsters are being pushed into irreversible and life-changing treatments before they are ready and sometimes without parental consent or knowledge.

Last month, Washington state passed House Bill 5599, stating that if a child runs off to a "host home" or shelter in search of gender-affirming care, the child's whereabouts should be reported to the state's Department of Children, Youth and Families rather than to the parents. And last year, California passed a bill declaring itself a "refuge" state for transgender youth, similar to Colorado, Illinois, Maryland, New Mexico and Minnesota.

On the flip side, transtracker.com says that 504 bills across the nation have been introduced that seek to block trans people from receiving basic healthcare, education and legal recognition, with 45 having been passed in states like Utah, Tennessee, Texas, Florida and South Dakota.

"There are some people who do benefit from transition, but there are some people who are harmed from transition," says Lisa Littman, a physician-scientist who is interviewed in the film.

While last year a study from the UCLA School of Law's Williams Institute said that the number of adults over the age of 24 who identify as trans remained static at 0.6 percent over the previous five years, the number doubled, from 0.7 percent to 1.4 percent, in the same time frame among children 13-17, hence the title of the film, Affirmation Generation.

The movie's focus is what Littman and some other researchers call Rapid Onset Gender Dysphoria (ROGD), and several of the detransitoners and experts featured say teens became sure they were trans after watching videos at Tik Tok, Tumblr and other online sources, especially during the pandemic amid school closures.

Some have questioned the motivations of the film in highlighting the cases it does. "This is not a documentary that seeks to explore a complicated subject. It's one that came in with a specific and, frankly, disturbing agenda," commented Scott Lentz in one of five reviews on online entertainment site IMDb. The other reviews were positive.

Among those featured in Affirmation Generation is Laura Becker. She is autistic and suffered from depression and anxiety, and was suicidal, she told Newsweek. But once she told a therapist she'd be more comfortable as a gay man, her now-deceased therapist focused on encouraging her to transition.

"When you go to a clinic in the current culture, the protocol is to confirm," she said. "There is no wait time, questioning or curiosity. They're basically excited or fearful of pushback. They're neglectful practitioners."

She began transitioning at age 18, including injections of testosterone and the surgical removal of both of her breasts, which she said led to more depression. When she was diagnosed four years later with Complex PTSD due to abuse suffered as a child, she transitioned back to female.

Now 26 and saying she is comfortable in her own body, she blames a "cultural obsession" for encouraging her to be trans. "There's a deconstructionist element to it, completely pushing against traditional values, including the reality of biological sex," she said. "Kids are pushed along on this conveyor belt that involves big pharma, billable insurance and media propaganda."

Since going public with her decision to detransition, she's been likened to a Nazi in social media and told she's "supporting the genocide of trans people."

Trans activists have accused those who highlight the few cases of those who reverse their transition as seeking to weaponize them. One 2021 scientific study noted the term "detransition" had "become associated with politically motivated attempts to impede access to gender-affirming care."

The proportion of those who detransition is small, although studies show a range from less than 1 percent to more than 10 times that. Most studies have focused on adults, however, rather than those who made their decision during the emotionally turbulent teenage years.

Affirmation Generation has come under as much attack as its participants.

A screening was canceled in April when a Texas venue received about 200 calls in a few days, some promising disruptions if the film were to unspool as had been planned, according to documents reviewed by Newsweek.

At a screening at a public library in Northern California, members of a pro-trans activist group called Gender Spectrum stood near the screen as the movie played holding derogatory signs. Gender Spectrum did not respond to Newsweek's several emailed requests for comment.

In response to the attacks, "We will deprioritize in-person events and will focus on online marketing," one of the filmmakers, Joey Brite, told Newsweek, noting that the movie has been viewed 70,000 times thus far on Vimeo and other outlets (it was temporarily suspended from Vimeo before being found not to have infringed its policies).

Brite is a self-described lesbian and "desister," someone who once considered themselves trans but never went through the medical or legal procedures involved with transitioning before ultimately aligning with their birth sex.

She told Newsweek she began thinking about the trans movement outside a bar three decades ago where a man was encouraging lesbians to take testosterone. "I saw young lesbians in the 90s raising $8,000 for mastectomies. It was a fad," she said.

Today, there are about 40,000 girls and young women who identify as trans and are raising money at Go Fund Me to pay for their mastectomies, the movie says.

"I thought I was trans until I was 30. I went to a therapist and thought she was going to give me the go-ahead for testosterone," Brite recalled. "But when I told her I thought I was a man, she did the unthinkable: She looked me in the eye and said I was not a man and I'd never be a man. 'You're a lovely, butch lesbian who needs to learn to love herself, and I'd like to help you do that'."

Brite said she's been trying to locate the therapist to thank her. She questions mainstream medical opinion on gender-affirming care.

According to the National Center for Transgender Equality: "A large body of research demonstrates that trans youth who receive transition-related health care to treat their dysphoria show decreased anxiety, depression, suicidal behavior, and psychological distress, and increased quality of life."

And two years ago, the American Medical Association cautioned lawmakers who seek to prevent children from transitioning. "Every major medical association in the United States recognizes the medical necessity of transition-related care for improving the physical and mental health of transgender people," the AMA said in a letter to the National Governors Association.

"Transgender children, like all children, have the best chance to thrive when they are supported and can obtain the health care they need," according to the letter, including "gender-affirming hormone therapy, and/or gender-affirming surgeries."

Lindner, a Grammy winning writer of music for TV, film and video games, said she became aware of the extent of the issue after watching her daughter and her friends, all of whom were diagnosed with autism or ADHD, obsess over gender during pandemic lockdowns three years ago at age 14. "It's all they talked about," Lindner recalled.

Lindner's daughter had multiple health issues, she said, including a belief that she was transgendera perception reinforced by a visit to a therapist who had suggested testosterone therapy. Shocked, Lindner said she had convinced her daughter to wait until she was 18 to make a decision.

Littman, the researcher, said that in recent years, the number of teens indentifying as trans from the same group of friends had greatly exceeded what would normally have been expected.

Among the characters in the movie, Joel says he was convinced he'd love himself more if he were a woman; Cat dreamt while sleeping that she was a boy and was "crushed" each morning when she woke up a girl; Stella says she felt "humiliated" to be in a female body; and Michelle said she learned she was transgender by exploring Tumblr.

One boasted of becoming an Internet influencer after transitioning, another said he was 99 percent certain he'd never regret transitioning and another spoke of a "honeymoon phase" of euphoria. Cat says she was given "one path" and that if she didn't take it, she might end up dead from suicide.

All speak of regrets. One realized after transitioning that they weren't really transgender; another spoke of "increased depression;" while another's health deteriorated to the point they walked hunched over and required the use of a walker. David says that after transitioning he was bitter and suicidal while others thought he was happy and heroic.

Becker, in the film, calls her double mastectomy "one of the biggest mistakes I ever made" and adds that her chest doesn't look male or female, but like "a form of mutilation."

She also spoke of a shift in her overall perspective on gender-affirming care and who should get it, a view echoed in the film by Lisa Selin Davis, author of Tomboy: The Surprising History and Future of Girls Who Dare to Be Different. "I want liberals to make room for gender diversity, and that includes masculine girls and feminine boys without telling them they need to leave their sex category," she says.

After the online release of Affirmation Generation, negotiations are now underway for wider distribution, Brite said, without giving details.

Read more from the original source:
The Trials of a Movie on Transgender Reversals - Newsweek

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Best Male Enhancement Pills Top Sex Pills for Men in 2023 - The Times of Israel

Boostaro is a completely safe and natural method of ending erectile dysfunction in men. This supplement has been formulated by Tom Bradford using effective ingredients that have been proven successful against erectile dysfunction. He spent years reading scientific literature to determine the best ingredients that could help him restore erectile function.

This dietary supplement uses a breakthrough new formula made using natural ingredients, including vitamin K2, L-citrulline, L-lysine, pine bark extract, magnesium, and vitamin C, among others. Boostaro delivers essential amino acids and nutrients to your body that help in providing you with multiple health benefits.

Every bottle of Boostaro contains 60 pills. You must take two pills daily to boost your sexual function. Taking this supplement daily can help in boosting nitric oxide levels and testosterone levels as it clears out your blood vessels and fights the root cause of poor sexual health by improving blood flow.

This healthy male virility supplement can provide essential nutrients to men, which can help them sustain high energy levels for a long period. This helps them to enjoy enhanced sexual desire and a better sex life. Boostaro can help boost your sexual health naturally without subjecting you to harmful substances.

You can buy Boostaro from its official website at lucrative discounts. It also comes with a whopping 180-day money-back guarantee.

Before moving on to the detailed Boostaro review, lets take a look at this sexual health supplements overview.

Category:

Dietary Supplement

Retailer:

ClickBank

Product Form

Capsules

Serving Quantity

Every Boostaro bottle contains 60 pills

Serving Size

Take two pills daily to experience the best results on your sexual health.

Product Features

Clinically studied ingredients

Key Benefits

Core Ingredients

Bonus Products

Guarantee

180-day money-back guarantee

Price

https://getboostaro.com/

Boostaro is a natural dietary supplement that has been formulated after extensive research to resolve the problem of erectile function in men and boost their sex life simultaneously. Before we understand how this supplement works, lets comprehend the relevance of Boostaro.

The problem of erectile dysfunction is related to capillaries which are blood vessels found in the penis. If these vessels are clogged with plaque, optimal blood circulation in the penis takes a hit. This plaque can be the result of poor eating habits or high cholesterol.

When you dont experience healthy blood flow, you are not able to experience normal erections. This hampers your sexual function and brings down your energy levels.

Why Are Prescribed Drugs For Erectile Dysfunction Harmful?Many people turn to prescription medication to get rid of ED. But, they do not provide a permanent solution to this problem. They do not clear out this plaque, they just relax your blood vessels temporarily so you feel that you dont have erectile dysfunction.

These medicines use chemicals that increase nitric oxide levels in the blood. They help in expanding the capillaries so that men enjoy uninterrupted blood flow. This helps them to enjoy the momentary enhanced sexual function.

Prescription medicines do nothing to promote your sexual health. Rather, they induce several side effects and impact your overall health negatively.

What Does Boostaro Do For You?Here comes the answer you were looking for. Boostaro works by supplying essential nutrients and amino acids to your sex organs that help relax blood vessels and improve blood flow. This supplement uses natural ingredients like vitamin K2, pine bark extract, vitamin C, and magnesium, among many others.

Boostaro helps increase nitric oxide levels naturally without subjecting your body to harmful chemicals that can induce awful side effects. It stimulates nitric oxide production that helps in relaxing the capillaries in the penis on demand to improve blood flow.

This dietary supplement uses a strong amino acid profile to optimize healthy circulation in your body, which in turn helps improve heart health. It can enhance male sexual health and boost testosterone levels by targeting the root cause of erectile dysfunction. You can enjoy high energy levels all day long with the help of this supplement.

Boostaro helps you to maintain longer and harder erections that can improve your sexual performance. When you enjoy better erectile function, your sex life also improves.

How Should You Consume Boostaro?Every bottle of Boostaro contains 60 pills. You have to take two pills daily to get the maximum sexual health benefits. Taking two pills daily can result in improved blood circulation in your sex organs and enhanced sexual function.

You must take these pills 20-30 minutes before a meal to increase nitric oxide levels and get rid of erectile dysfunction.

It is important to note that taking more than 2 pills every day wont provide you with higher energy levels or added benefits. You must follow the recommended dosage of Boostaro or it might harm your health.

What Are The Ingredients Incorporated In Boostaro?Here is an overview of the ingredients that are blended together to form the effective formula of Boostaro:

Vitamin CVitamin C is essential for the body as it helps to support the immune system, maintain healthy skin, and prevent damage to cells caused by free radicals. It is also necessary for the production of collagen, which is a protein that helps to keep the skin, bones, and joints healthy.

Vitamin C also helps to absorb iron from plant-based foods and plays a vital role in the production of neurotransmitters, which are essential for brain function.

Vitamin C plays a crucial role in male sexual health and libido. It helps to improve blood flow, which is essential for achieving and maintaining an erection.

Vitamin C also helps to reduce stress and anxiety, which can have a negative impact on sexual performance. Additionally, vitamin C is involved in the production of testosterone, which is a hormone that is essential for male sexual health.

Vitamin K2Vitamin K2 is a fat-soluble vitamin that plays a crucial role in the activation of proteins that are important for blood clotting, bone metabolism, and heart health.

Recent studies have shown that vitamin K2 can help improve male sexual health by promoting the production of testosterone, a hormone that is essential for male sexual function.

Vitamin K2 works by activating a protein called osteocalcin, which is responsible for regulating the production of testosterone. Clinical trials have shown that men who consume higher amounts of vitamin K2 have higher levels of testosterone and better sexual function compared to those with lower levels of vitamin K2.

In addition to boosting testosterone levels, vitamin K2 also helps improve blood flow to the genitals, which is essential for maintaining an erection. It does this by activating a protein called matrix Gla protein, which helps prevent calcium buildup in the arteries. This, in turn, helps improve blood flow to the penis, leading to better sexual function.

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L-LysineRecent clinical trials have suggested that L-lysine may also have benefits for male sexual health. Studies have shown that L-lysine can help increase testosterone levels, which is the hormone responsible for male sexual desire and performance.

One of the ways L-lysine works is by blocking the activity of arginine, another amino acid that is known to inhibit the production of testosterone. By blocking arginine, L-lysine can help increase the availability of testosterone in the body, which can lead to improved sexual function.

In addition to its effects on testosterone, L-lysine has also been found to have antiviral properties. This is because it can bind to the herpes simplex virus, which is known to cause genital herpes and prevent it from replicating.

Another way L-lysine can help boost male libido and virility is by improving blood flow to the penis. This is because it can increase the production of nitric oxide, a molecule that relaxes the blood vessels and allows more blood to flow through.

L-CitrullineL-citrulline is an amino acid that is naturally found in watermelon, as well as in other fruits and vegetables. When ingested, L-citrulline is converted by the body into L-arginine, another amino acid that helps to increase blood flow throughout the body.

L-citrulline works by increasing blood flow to the penis, which can help to improve erectile function and increase sexual arousal. When L-citrulline is converted into L-arginine, it helps to stimulate the production of nitric oxide, a natural compound that relaxes blood vessels and improves blood flow.

In addition to improving blood flow, L-citrulline may also help to improve endurance and reduce fatigue, which can be beneficial for men who want to improve their sexual performance.

MagnesiumMagnesium is involved in over 300 biochemical reactions in the body, including muscle and nerve function, protein synthesis, blood glucose control, and blood pressure regulation. It is also essential for the production of sex hormones, including testosterone, which is critical for male sexual health and libido.

Clinical trials have found that magnesium deficiency is associated with decreased testosterone levels and reduced sexual function in men. This is because magnesium is required for the production of testosterone, which is necessary for male sexual health and libido. Low levels of testosterone can lead to a decrease in libido, erectile dysfunction, and other sexual problems.

Magnesium also works to improve blood flow to the penis, which is essential for achieving and maintaining an erection. It does this by relaxing the blood vessels and increasing blood flow to the penis, which can improve sexual function and performance.

Pine Bark ExtractPine bark extract contains several active ingredients that have been shown to improve male sexual health. The two most important active ingredients are proanthocyanidins and arginine.

Proanthocyanidins are powerful antioxidants that can help improve blood flow in the body. In particular, they can help increase blood flow to the penis, which can lead to improved erectile function.

Arginine is an amino acid that is essential for the production of nitric oxide in the body. Nitric oxide is a molecule that helps relax the blood vessels, which can improve blood flow to the penis.

All in all, pine bark extract works by increasing blood flow to the penis, which can improve erectile function. The proanthocyanidins in pine bark extract help improve blood flow by acting as antioxidants and improving the health of the blood vessels. The arginine in pine bark extract helps improve blood flow by increasing the production of nitric oxide.

In addition to improving erectile function, pine bark extract has also been shown to improve libido in men. This may be due to its ability to increase blood flow to the genitals, which can increase sensitivity and arousal.

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What Is The Scientific Evidence Behind Boostaro?A study published in the Journal of Medicinal Food found that pine bark extract reduced inflammation in the prostate gland and improved urinary symptoms in men with benign prostatic hyperplasia (BPH). The study concluded that pine bark extract may be a safe and effective alternative to traditional treatments for BPH.

Pine bark extract has also been studied for its potential to boost testosterone levels in men. In a study published in the Journal of Reproductive Health and Medicine, researchers found that men who took pine bark extract experienced significant increases in testosterone levels. The study also found that pine bark extract improved sperm quality and motility.

One study published in the Journal of Sexual Medicine found that L-citrulline supplementation improved erectile function in men with mild to moderate ED. The study involved 24 men who were given either L-citrulline or a placebo for one month. The results showed that the men who took L-citrulline experienced significant improvements in their ability to achieve and maintain an erection.

Another study published in the British Journal of Nutrition found that L-citrulline supplementation improved blood flow in healthy men. The study involved 12 men who were given either L-citrulline or a placebo for one week. The results showed that the men who took L-citrulline had increased blood flow to their muscles during exercise.

Vitamin C has also been shown to improve sperm count and motility. A study published in Fertility and Sterility found that taking vitamin C supplements increased sperm count and motility in infertile men.

Moreover, a study published in the American Journal of Clinical Nutrition found that men who consumed more vitamin C had a lower risk of developing erectile dysfunction. The study involved 3,724 men who were followed for 10 years.

The results showed that the men who consumed more vitamin C had a 42% lower risk of developing erectile dysfunction compared to those who consumed less vitamin C.

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What Are The Health Benefits Of Boostaro?The Boostaro premium dietary supplement is formulated using highly effective natural ingredients that have been proven to improve sexual performance, blood circulation, and heart health in men. This supplement can provide your body with many more health benefits.

Lets take a detailed look at all the health benefits of Boostaro.

Boosts Healthy Blood FlowThe main health benefit of Boostaro is that it can ensure healthy blood flow to your penis. This supplement uses ingredients like pine bark extract, vitamin K2, L-citrulline (an essential amino acid), vitamin C, and others to improve blood circulation, remove plaque, and maintain healthy blood vessels.

Boostaro can help you regain your youthful erectile function by removing clogged plaque from the capillaries and boosting nitric oxide levels. This supplement can improve your sexual function and support sexual health significantly.

Helps Treat Erectile DysfunctionBoostaro is formulated by Tom Bradford to treat erectile dysfunction in men. All the ingredients that go into the formula of this dietary supplement can support erection quality to boost your sexual performance.

This supplement targets the root cause of erectile dysfunction by enhancing blood circulation to your penis. If your penis does not receive enough blood, it cannot maintain longer and harder erections. As a result, you experience poor sexual function.

Boostaro results in improved blood flow in your penis which in turn helps improve erectile function.

Offers High Energy LevelsThis dietary supplement supplies essential amino acids and nutrients to the male organs from natural ingredients like vitamin K2, pine bark extract, vitamin C, L-lysine, and others that help in stimulating energy production in the body.

They reduce inflammation in your body and support high energy levels so that you can enjoy your sex life with your partner. This supplement supports erectile function and sexual function by elevating your mood levels and providing an energy boost.

Stimulates Nitric Oxide ProductionAll the ingredients in Boostaro work in synergy with each other to increase nitric oxide production in your blood. This supplement relaxes your blood vessels and improves blood flow. Boostaro supports erectile function in your body increasing the levels of nitric oxide that have a direct impact on your sexual performance.

This sexual health supplement is highly beneficial for those men who are not able to maintain durable erections. Once their nitric oxide levels return to normal, they can enjoy the maximum sexual function.

Visit the official Boostaro website to learn more! >>>

Boosts Heart HealthThe Boostaro supplement uses a strong amino acid profile to relax your blood vessels and result in increased blood flow in the body. It helps in supporting your heart health as blood circulation improves. Boostaro can also promote high energy levels in your body using ingredients like vitamin C that help in improving your cardiovascular health.

Helps Boost Testosterone LevelsBoostaro has been formulated using highly effective natural ingredients that can increase your testosterone levels significantly. Testosterone is one of the most important male hormones that regulate sexual function in the male body.

This sexual health supplement can improve blood flow in your body by supporting high testosterone levels.

Promotes Sexual PerformanceBoostaro is a sexual health supplement that can increase nitric oxide levels in your body to help you get rid of erectile dysfunction and other sexual health issues. This supplement can improve blood circulation to your sex organs which can increase your energy levels and help you achieve peak sexual performance.

All the ingredients in Boostaro are packed with solid sexual health benefits for the male body.

Regulates Blood Pressure LevelsWhen your body experiences normal blood flow, it helps in reducing high blood pressure levels. Some of the natural ingredients found in Boostaro, like vitamin K2, pine bark extract, and vitamin C help in regulating high BP in daily users.

This supplement improves blood flow in your body by dilating blood vessels which helps support normal BP.

Enhances Sexual FunctionBoostaro is equipped to boost your sexual function and support sexual health by enhancing your libido. This supplement helps in improving blood flow to the male organs, which helps men enjoy better sexual arousal. Taking this supplement daily can help you enjoy higher sexual desire and better sperm count.

Supports Overall HealthThe formula of Boostaro is rich in amino acids and nutrients that help in improving blood flow in the entire body. This supplement helps you enjoy enhanced muscle and bone health which allows you to lose fat and build your desired body quickly.

Boostaro is packed with overall health benefits that can improve your quality of life to a great extent.

Order your supply of Boostaro now and start enjoying the benefits!

Is Boostaro Safe For Daily Consumption?The Boostaro supplement is formulated using only 100% natural ingredients and amino acids that are free from toxins, pesticides, and chemicals. Ingredients like pine bark extract were often used in traditional medicine to help in the treatment of erectile dysfunction.

The formula of Boostaro is gluten-free, non-GMO, vegan-friendly, and soy-free. It uses a strong amino acid profile to boost blood circulation and nitric oxide levels in your body without the use of any artificial substances.

Boostaro is produced in a GMP-certified and FDA-approved facility in the USA under strict supervision to ensure maximum purity and quality.

Hence, Boostaro is completely safe for everyday consumption.

What Is The Price Of Boostaro?Boostaro is available only on its official website. You wont get the Boostaro supplement on other websites. You can get this supplement at the following prices on the official site:

Original post:
Boostaro Reviews Effective Male Enhancer or Real Side Effects Risk? - The Times of Israel

By Alex Raskin Sports News Editor For Dailymail.com 01:04 23 Apr 2023, updated 15:22 23 Apr 2023

Golden Boy Promotions executive and boxing legend Bernard Hopkins has been accused of rubbing testosterone cream on Gervonta Davis in an alleged effort to taint the fighter's drug sample ahead of Saturday's bout with Ryan Garcia in Las Vegas.

Garcia, who is promoted by Golden Boy, had a tense face-off with Davis after Friday's weigh-in, which briefly devolved into a shoving match between the two 136-pound fighters. Hopkins stood on the periphery of the exchange, and appeared to rub his hand across Davis' back at one point, drawing the ire of the Baltimore native and his camp.

'I should've slapped the s*** outta B-Hop as soon as he touched me,' Davis wrote in a since-deleted tweet.

Then on Saturday, Davis' trainer Calvin Ford promoted a theory on social media that Hopkins was rubbing testosterone cream on the 28-year-old's back in order to taint a drug test.

'Coach beware of B hop and testosterone cream,' read a text message that Ford shared on Instagram. '[It] will make you test dirty. Be careful.'

Ford added his own caption: 'See this is why Bernard touch him.'

A Golden Boy spokesperson did not immediately respond to DailyMail.com's request for further comment.

Davis continued remarking on Hopkins after Friday's fracas.

'[Hopkins is] talking about he about that life, man, nobody's worried about his old ass, he needs to sit back and let the youngins do it,' Davis said Friday of the retired champion and former prison inmate, who has been stabbed numerous times.

In any case, both fighters managed to clear the 136-pound limit, which was previously agreed upon during their lengthy negotiations.

'Punishment, knockout. It's going to be crazy,' Davis said. 'Don't blink your eyes, don't get no popcorn, don't get no drinks, none of that. Make sure you're focused on the fight because it's gonna be an incredible fight.'

Boxing fans have spent the past couple of decades watching top fighters avoid each other in their primes and carefully pick lesser opponents so they can boost their records.

The lack of big-name bouts that would've driven even casual fans to order pay-per-view helped create a noticeable lack of buzz in the sport.

Saturday's 12-round lightweight showdown between the undefeated Davis and Garcia doesn't follow that path.

Both fighters are at the top of their games and because they opted to meet, they have sent needed electricity through the sport. The year's most-anticipated fight will take place Saturday in Las Vegas.

'I feel like this fight is big for the sport,' Davis, who is from Baltimore, said Thursday. 'We're drawing in a lot of people and a win on that night is really like winning a world title again.'

Garcia said seeing his face around the Las Vegas Strip brought home the meaning of this fight.

'This is what I've dreamed of since I was a little boy and now I'm here,' Garcia, who lives in Los Angeles, said Thursday.

Even though both sides recognize what Saturday means, there is genuine animosity between the boxers and their camps, a longtime war of words that continued through Thursday's news conference.

Davis accused Garcia of possessing only a left hook, and Garcia said Davis didn't have much punching power. They traded several barbs during the presser, calling each other delusional, and chirped again when they came face to face for the traditional pre-fight promotional pose.

Both promoters didn't hold back, either.

Oscar De La Hoya, CEO of Golden Boy Promotions, got it started by saying Davis' camp kept asking for various contractual demands to be met, which 'points to a team looking to protect their fighter. ... Nothing feels worse than your team not believing in you.'

'That is a confident fighter,' De La Hoya said, looking at Garcia. 'That's why you're going to see Ryan come out as the new face of boxing Saturday night.'

Leonard Ellerbe, CEO of Mayweather Promotions, didn't back down.

'We're the A-side of the situation,' Ellerbe said. 'That's how the A-side carries itself.'

Some of the back-and-forth likely was promotional schtick, but given the fight is a sellout and is expected to bring in major pay-per-view numbers, it didn't need much extra hype.

De La Hoya and Ellerbe knew what was at stake when negotiating this match, and they put whatever differences they had aside to make it happen.

'It's not often in today's age you see two young fighters both undefeated, both in their prime, step in the ring together,' said Tom Brown, president of TGB Promotions. 'This fight will be an instant classic, an all-out war, a Hagler versus Hearns. The good thing is with Tank Davis, we have Hagler.'

Marvin Hagler knocked out Thomas Hearns in the third round of their epic 1985 fight, one of the most action-packed bouts in history.

The Davis-Garcia winner could set up a showdown with undefeated Devin Haney, who owns all four major championship belts in this division. Haney faces former champ Vasiliy Lomachenko in May, also in Las Vegas.

Davis is a minus-290 favorite, according to FanDuel Sportsbook, and he has devastating power. Of his 28 victories, 26 have come by knockout.

Part of what makes this match so intriguing is both boxers are capable of ending it at nearly any time. Garcia has won 19 of 23 matches through knockouts.

It's like the 1990s when boxing fans knew they couldn't miss any part of a Mike Tyson fight because he could end it within seconds. In this case, both boxers are capable of doing that.

A great show could elevate Davis or Garcia into a Tyson-like status that boxing badly needs, or at least begin generating the types of conversations in combat sports that have most recently been reserved for mixed martial arts.

In the co-main event, undefeated WBA super middleweight champion David Morrell Jr. faces former Olympic bronze medalist Yamaguchi Falcao. Morrell, 25, is 8-0 with seven knockouts, and 35-year-old Falcao is 24-1-1 who has won eight matches in a row, including five last year.

FanDuel lists Morrell as a minus-1,800 favorite.

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Gervonta Davis' trainer claims Bernard Hopkins secretly rubbed testosterone cream on the boxer - Daily Mail

Testosterone is the primary sex hormone in males. Its produced in the Leydig cells in the testes, and it plays an important role in sex drive, bone mass, body composition, muscle mass and strength, voice timbre, and sperm production.

Certain foods can boost your testosterone levels, or lower them. Researchers of a 2021 study followed 3,283 Taiwanese men over six years and found that those who ate a low-quality diet had poorer testicular function and low testosterone levels. The men who ate a diet rich in leafy greens, legumes, and dairy had better testicular function and testosterone levels. A poor diet was defined as: A typical Western diet with lots of processed meats and fish, deep-fried foods, organ meats, and flour products cooked in oil.

You can boost low testosterone levels naturally by eating a healthy diet and adding a few foods that are known to help boost testosterone levels. Heres a look at some foods to include.

A 2020 study following men and women with obesity found that taking fish oil with omega-3 fatty acids upped testosterone levels in men, but not women. The study found that DHA, a type of fatty acid found in fish, was particularly helpful.

Another older study from 2013 showed that fish oil and CLA (conjugated linoleic acid) increased testosterone synthesis and may help boost athletic performance for both endurance and resistance training.

The 2021 study of Taiwanese men previously mentioned found that consuming milk and dairy products protected against low testosterone levels. Another 2019 study of middle-aged and elderly men in Taiwan also drew a similar conclusion. Fortified milk is a key source of Vitamin D, which is essential for testosterone production. Ensuring vitamin D levels are within normal limitsmay it be with food, sunlight, or supplementationis vital for overall hormone health. However, more research is needed to draw robust conclusions on how dairy products affect testosterone production.

The Taiwanese study found that eating legumesa family that includes beans, peas, and peanutscan protect against low testosterone levels and poor testicular function. This may be due to the fact that legumes are rich in two nutrients associated with higher testosterone levels: zinc and magnesium.

Dark, leafy greens are nutrient-dense, high in fiber, and filled with micronutrients that promote good health. The Taiwanese study also found that men who ate more dark, leafy greens had higher testosterone levels than men who did not. A 2018 study also saw similar results.

Natural medicine practitioners often point to honeys many uses, from soothing a childs sore throat to its antibacterial properties. A 2019 review of the literature also found that honey can increase testosterone levels in men by increasing the production of luteinizing hormone, enhancing the viability of Leydig cells, reducing oxidative damage in Leydig cells, and inhibiting aromatase activity in the testes. However, more research on humans are still needed to confirm the effect of honey on testosterone.

A 2019 review concluded that onions may help male testosterone levels by increasing the production of luteinizing hormone, enhancing the antioxidant defense mechanism in the testes, and defending against inflammation and insulin resistance. However, more clinical trials are needed to determine how onion can increase testosterone levels in humans.

Whole eggs contain cholesterol, which your body needs to make testosterone. A 2021 study following young men on a weight training program over 12 weeks saw that those men who ate eggs daily increased their testosterone levels. They were separated into two groups, one that ate three whole eggs daily and one that ate six egg whites. The researchers found that the group that ate the entire eggs increased their testosterone level more.

Studies have shown that eating high levels of flavonoids, a group of helpful compounds in many fruits and vegetables, is good for your health, and for producing testosterone. Some studies show flavonoids can prevent, or delay, hypogonadism (decreased functional activity of the gonads) in males as they age.

Foods high in flavonoids include:

Oysters are full of zinc, a mineral thats essential for making testosterone. While taking in extra zinc may ensure youre not deficient, getting more than you need wont do much to increase your testosterone level.

There are countless herbs on the market that tout their testosterone-boosting effects but have little evidence backing up those claims. However, a 2021 meta-analysis found that these four herbs show promise, although more research is needed:

You can make other changes to help improve your testosterone levels.

Getting active yields lots of benefits, from improved mood, weight control, and fitness to increased testosterone levels in men. Strength and endurance training (cardio) can both increase your testosterone levels.

Research shows that people who are overweight or have obesity show lower circulating levels of testosterone. Getting to a healthier weight may help your overall health as well as your testosterone levels. Just be sure not to eat too little because this can also negatively impact your testosterone levels.

Eating a healthy diet with enough fat is important for overall health and testosterone levels. Cholesterol comes from some types of fat, and thats what your body uses to make the hormone. Some studies recommend getting 25% of your calories from fat.

Some studies show that when men are sleep deprived, their testosterone levels lower. A natural way to increase your testosterone is by focusing on getting meaningful and adequate sleep.

Environmental factors and unhealthy lifestyles can contribute to low testosterone levels.

Your level is considered low when a blood test shows testosterone levels below 300 nanograms per deciliter (dl) for males, and 15 nanograms per deciliter for females. If its lower than that, you may have a condition called hypogonadism.

Low testosterone can cause symptoms such as:

Several factors can influence your testosterone levels. Some of them, you cant control (like age). Others, such as your diet, alcohol or drug use, body weight, and activity level, you can control. Heres a look at the major factors.

Male testosterone levels generally start decreasing gradually after age 30. Levels decrease by 0.4% to 2% a year.Some studies show that up to 50% of middle-aged people with diabetes or obesity go on to develop hypogonadism.

Men who are overweight or have obesity tend to have lower testosterone levels. Talk with your healthcare provider about what a healthy weight looks like for you and how to achieve it.

On the flip side, having too big a gap between the calories you burn and the calories you use can also decrease your testosterone. A 2021 review of studies also found that low-fat diets decreased testosterone levels in men, especially those of European descent. The review authors concluded more research is needed to understand why.

Substance abuse can cause low testosterone levels. Alcohol, opioids, and steroids can reduce testosterone production, and nicotine, cannabis, and amphetamines can also impact your fertility. Reducing or eliminating these substances can help you regain healthy hormone levels.

Many supplements claim to boost testosterone, but a 2019 study found less than a quarter had any evidence to back their claims. Some, about 10%, actually lowered testosterone.

A poor-quality diet with too few nutrients and too many calories can lead to weight gain, obesity, metabolic issues, and lower testosterone levels. Researchers have found that some foods are especially detrimental. They include:

Many things can cause your testosterone levels to drop, from aging to a less-than-ideal diet, substance abuse, and inactivity.

The good news is that you can boost your testosterone levels by fine-tuning your diet and adding new foods. Some foods to include are fish oil, dairy products, leafy greens, legumes, fruits and vegetables containing flavonoids, and oysters.

See the original post:
Foods That Boost Testosterone Naturally - Health.com

April 20, 2023

2 min read

Source: Healio Interviews

Disclosures: Hackett reports serving as an adviser to the men's health website, Ted's Health. Irwig reports no relevant financial disclosures.

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Providers are too cautious with testosterone therapy. The myth is that increasing testosterone level will cause prostate cancer. If you start with a myth, you have to disprove that myth with a trial that is probably too big to ever conduct and that nobody will ever fund. Although repeated studies have shown no risks with testosterone therapy, those small studies are never looked at.

Testosterone therapy crosses a number of specialties, and we are a bit locked into our specialties. For example, the European Association of Urology recommends that anybody starting testosterone needs three rectal examinations in the first 12 months. The endocrinologists published guidelines that do not require a digital rectal exam at all. When you have guidelines, you need to make sure you have proper multidisciplinary panels.

If you read a summary of the T Trials, it tells you that there is high-level evidence that testosterone therapy improves cognitive function, improves muscular strength, improves insulin sensitivity, improves walking distance and sexual function. Yet in the final sentence, the experts say they advise caution until longer-term studies are available.

The European Male Aging Study showed that a 20% reduction in weight was required to achieve a significant reduction in free testosterone, and this is simply not achievable for the vast majority. Dietary interventions have repeatedly failed to produce meaningful long-term weight reduction, and U.S. obesity and diabetes rates increase year by year. In the T4DM trial, there was a 40% reduction in the testosterone therapy group for progression to diabetes. Diabetes is the biggest major health problem the U.S. faces. Testosterone therapy is a major step forward, but people just read the study and concluded they need longer-term information.

A bigger study is expected to come out later this year or early next. Im still not sure it will satisfy everybody. But I think there are quite good studies out there now.

There are certain cases where I think some people are being a little bit too cautious with testosterone. There are some doctors who may not be comfortable giving testosterone to a man who has coronary artery disease or a history of treated prostate cancer, whereas there are no good data showing that testosterone would harm men with this history.

But in many more cases, we have the opposite. Some clinics have been too liberal with dispensing testosterone for low libido or erectile dysfunction without doing an adequate assessment and evaluation. Many of these clinics are just out to make money by putting as many men on testosterone as possible. Testosterone should be prescribed to men who have androgen deficiency who are not able to make enough testosterone on their own.

Functional hypogonadism refers to low testosterone levels that are often borderline where there is no structural abnormality. A lot of times these causes are reversible. If you treat the underlying cause, that can reverse low testosterone levels without replacement therapy, for example, weight loss for obesity and increasing sleep in those with inadequate sleep.

We need more high-quality, randomized control trials that involve testosterone for a longer duration. A lot of patients are put on testosterone for years at a time, but we dont have studies examining the effects of taking testosterone for years at a time.

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Are providers too cautious with prescribing testosterone therapy? - Healio

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