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Apr 23

Best Home Fitness Equipment | Best Home Treadmill …

IS NOW

Welcome to the nation's largest specialty fitness retailer. Our store logo and signage has changed, but our team of Fitness Consultants and their commitment to delivering a superior customer experience has not.

Find the same great people, prices and products. Get more tools and resources to help you achieve the results you desire.

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Apr 22

Soma Spray For Long Term Weight Loss | HGH.com

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Apr 22

Losing Weight After 60 Is Hard Here Are 9 Ways to Drop …

Lets face it trying to lose weight after your 60 years old is really hard. Back in the day, you could eat whatever you wanted (for the most part). Now, you eat a Hersheys Kiss, and you gain 2 pounds overnight.

As our bodies age, we lose our ability to eat whatever we want. Suddenly, we have to track calories and steps to stay ahead of the scale.

Before we get into 9 ways you can realistically lose weight, stay in shape, and feel like youre 25 again, its important to understand why keeping the weight off has suddenly become so difficult.

If youre 65+ and are enrolled in Medicare, there are plans that offer free gym memberships as a part of your health insurance. It's never been easier to get motivated and stay in shape! Learn more

Losing and maintaining your weight can start to become an issue as early as age 50, though many experience this annoyance around age 60.

What is going on?

For starters, your metabolism slows down as you age.

Robert Herbst, a personal trainer and 19-time World Champion in powerlifting explains, Im 60, so I know what it means to be 60. The slowing of the metabolism is a function of decreased production of testosterone and human growth hormone (HGH), which causes a loss of muscle mass.

Dont worry that loss of muscle mass can be reversed, and well get to that in the next section.

Carolyn Dean, MD and author of 30 books, including The Complete Natural Medicine Guide to Womens Health also explains, The loss of nutrients such as magnesium has decreased the production of metabolism-boosting hormones, so your weight loss efforts are handicapped.

In essence, this isnt your fault. With age, your body becomes less efficient with producing the key hormones it needs, which makes losing weight well, really hard.

For women, perimenopause and menopause are a reality of your 50s and 60s. Because of this shift, you actually burn fewer calories than you used to.

Jill McKay, Certified Personal Trainer and Group Fitness Instructor, explains, With menstruation, our body temperature would fluctuate, so we would get a bonus calorie burn of about 300 calories per month. Its not much, but it adds up over time.

Another issue that comes with both perimenopause and menopause is insulin-resistance, which makes losing weight even more difficult.

This means that the things you used to eat, you cant eat anymore! That also goes for portions you might not be able to eat as much as you could before without gaining weight.

When youre nearing retirement, theres more time. More time to exercise, of course, but is that really how we like to spend our free time?

Jill notes that, generally speaking, older adults often have more opportunities for socializing (and better finances to go to nice dinners).

In fact, were more likely to eat more if were around other people who are eating. All that socializing is making it harder to stay in shape.

For most people, losing weight after 60 is hard, but thats normal. However, if losing weight is exceptionally hard, you may want to check with your doctor that you dont have any health conditions.

The two most common health conditions that can cause weight gain are 1) the thyroid losing function, and 2) insulin becoming less functional.

The common test called hemoglobin A1c can tell you if youre able to metabolize your sugars well. If not, you could be at risk for diabetes.

For women, these conditions are most common around menopause.

So, losing weight after 60 is a real problem that many men and women face. However, there are some tricks to nudging that weight off so that you can tip the scale in your favor.

Related: Over 60? How to Use Smartphone Apps to Lose Weight and Track Fitness

Strength training, also called resistance training, isnt usually the first thing older adults think of when they think of exercise. Typically, cardio exercises, like walking on a treadmill or hopping on an elliptical are the most common.

However, Idea Fitness Trainer of the Year, Carol Michaels, worries that many seniors are forgetting about strength training.

The missing exercise component to help those over 60 lose weight is oftentimes strength training. This is an exercise using weights (or your own body weight) to strengthen and build muscle. It increases the size and strength of the muscle fibers and strengthens the tendons, ligaments, and bones.

As we age, we lose muscle mass mainly because of the slowing metabolism, which then contributes to an even slower metabolism, and suddenly, youre in a vicious cycle.

However, you can stop that cycle of muscle loss by strength training in fact, you can reverse the muscle loss at any age.

Carol continues, Since muscle is metabolically active, the more muscle mass that you have, the faster your metabolism. Therefore, strength training can help with weight loss.

But the benefits of strength training dont stop at weight loss. Other benefits of strength training include:

Who thought exercise could actually energize you?

Robert Herbst offers another way to think about strength training, The body will build additional muscle which is metabolically active and burns calories, even when at rest. Having this new muscle also raises the metabolism, just like a six cylinder car burns more gas than a four cylinder one, even when idling at a red light.

In essence, your new muscle will help you burn more fat, and youve suddenly stopped the vicious cycle of aging, and instead started a cycle of weight loss and weight management.

Now that were on the same page strength training is awesome! you might be wondering how exactly to go about this.

Carol says that many older adults around age 60 dont know where to begin. Should you go to the gym and use the machines? Should you buy some free weights?

A few popular machines you can use at the gym

She explains, Although machines can be helpful for those with balance issues, exercise with free weights has several benefits.

Free weights can be used at home or at the gym

Gyms also have free weights, so if youd rather pay for a gym membership than buy your own free weights, you have the choice.

Sure, strength training sounds nice, but if you think Im going to do it every single day for 2 hours a day

Dont worry. You dont have to do strength training like a madman to get the benefits.

Carol suggests that you should aim for 2 times per week.

Strengthen each muscle group, alternating from upper to lower body. Make sure to work the front, back, and side of the body so that you do not create imbalances. If you are new to exercise and over 60, you might start with a very light weight.

Once you have your exercises planned, Carol suggests doing 5-10 repetitions of that exercise. By the 5-8th repetition, you should start to feel the muscle really working. By the final repetition, you should feel that youve worked the muscle, but youre not exhausted. If youre exhausted, youre doing too much weight.

You can call your local gym in order to have a personal trainer show you what exercises to do, but there are a lot of experts online who have strength training programs with pictures and tutorials.

Bodybuilding.com dont be scared off by the name has a huge amount of pre-planning workout regimens. You can sort them by level beginner, intermediate, and advanced as well as length, 4, 6, 8, 12 weeks, etc.

You can browse those workout plans here: https://www.bodybuilding.com/workout-plans.

Dieting after 60 is confusing even if carb-heavy meals and delicious desserts have never been an issue for you, you might start to notice your body changing. That daily dessert might cause you gain weight, even if youve stayed the same weight for years.

But the bigger problem is that older adults over age 60 tend to have higher blood sugar due to insulin resistance.

Denny Hemingson, a 61-year-old Functional Diagnostic Nutrition Practitioner explains, Insulin signals the liver, muscle, and fat cells to take up glucose out of the blood stream. When those cells become resistant to insulin, glucose doesn't get used and ends up staying in the blood creating high blood sugar. Eventually, this leads to pre-diabetes, metabolic syndrome, and type II diabetes. In this state, it's much harder for the body to release extra pounds.

The solution? Reducing carbohydrates. Denny goes on to say that focusing on blood sugar retention over 60 is an important reality, and by reducing carbs, youre reducing your blood sugar, which will make it easier to maintain your weight.

Carolyn Dean is an advocate for the Keto diet, which is a high fat, moderate protein, and low carb diet. This allows the body to use up carbohydrate stores of sugar called glycogen, and then turn on fat burning to burn excess fat cells as energy.

The Keto diet is slowly gaining more recognition in the fitness and medical community as a way to burn fat faster than ever before, but its still recommended that you talk with your doctor before trying it.

Carolyn says that with the Keto diet, your goal is restrict carbs to 20-50 grams per day.

Drinking water doesnt in itself help you lose weight, but the reality is that many people think theyre hungry when theyre really just thirsty.

The cure? Drink a ton of water.

Carolyn and Denny both advise that you drink half your body weight (in lbs) in ounces of water. Carolyn explains, Often, people think they are hungry but they are really thirsty.

So, for example, if you weigh 200 pounds, you should drink 100 ounces of water. Thats about 5-6 bottles of water per day.

Something you may have never thought of is adding magnesium to your diet.

Magnesium is an energy mineral and weight loss/metabolism-boosting mineral that helps synthesize proteins, carbs, and fats.

Carolyn explains that of the 700-800 magnesium-dependent enzymes, the most important enzyme reaction that magnesium contributes to involves the creation of energy. Magnesium activates adenosine triphosphate (ATP), the fundamental energy storage molecule of the body.

Getting magnesium into your diet is as simple as adding to your water. Carolyn says, Add sea salt and an absorbable form of magnesium, such as magnesium citrate powder, to your water. This will definitely make following low-carb diet easier, and it will help you avoid the loss of energy, sluggishness, and headachy feeling associated with electrolyte depletion.

Another thing to note is that sugar stresses the body and depletes magnesium, so staying away from sugar can help neutralize the effects of stress. Who knew?

OK, dont get sunburnt or anything, but make sure to get some Vitamin D!

Without Vitamin D, you might find yourself running to the cupboard for more snacks than you need.

Denny explains, Vitamin D works alongside the hormone leptin to regulate hunger signals. When Vitamin D is deficient, this process malfunctions causing people to overeat.

Get outside, take in some sunshine, and bask in the fact that youre controlling your appetite!

Its no secret that stress can cause us to overeat.

When youre stressed, do you go to the freezer for some chocolate ice cream? Youre not alone.

A great way to manage stress is to relax. And sometimes, you need some prompting.

Denny suggests yoga, which does more than just ease stress. Youll improve your balance, your core strength, and your mindfulness.

Other ways to manage stress are to consider meditation, prayer, and nature walks.

The app called Simple Habit has free, quick meditations that you can try if youre interested in giving meditation a shot.

Popular meditations include "Simple Habit Starter" and "Coffee Meditation," which are both only 5 minutes long.

Sleep has incredible effects on your overall health.

Not only will you have more energy for that strength training workout, but when you sleep, your body actually produces the human growth hormone (HGH).

Denny advises that you get 7-8 hours of quality sleep. The best way to make sure your sleep is of quality is to:

Sleep brings youthfulness, so dont skimp on it!

Meal prepping can force you to eat healthier foods throughout the week, even when you dont have time to cook. (Or you just dont feel like it.)

Jill advises, Stop eating manufactured food. Yes, this is challenging if you live alone. Look into meal prep for the week that way, you cook larger portions and break them down to smaller meals during the week.

If youve never tried meal prepping before, Thirty Handmade Days has an excellent blog post called Meal Prep Ideas Why, What, and How.

There, youll learn how to do it, and there are even recipes to get you inspired.

Finally, dont be so hard on yourself!

If you go an entire week without losing an ounce, dont worry! That can be extremely normal.

All of our experts advise that you dont cut your calorie intake by too much. Jill explains, Adequate calories are important don't cut calories too drastically! Fast weight loss leads to muscle loss, and that changes body composition (and can slow the metabolism.

In other words, all your strength training progress can be lost if you arent eating enough.

Finally, dont push yourself too hard in the gym, either. Jill explains her own pet peeve: One of my biggest pet peeves is when an inexperienced personal trainer tries to make a Baby Boomer complete a workout that is so challenging that they are so sore the next day that they can barely brush their teeth or get up off the toilet. That is NOT necessary!

If you need a break, take one! If you feel the weight is too heavy, lighten up! The goal is to keep yourself healthy not to make yourself miserable.

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Apr 22

HCG Diet Meal Plan, Examples & Phases – GuideDoc

Understanding the phases of the HCG diet meal plan and preparing meals that fit into the high protein diet.

The HCG diet involves caloric restrictions and regular injections of the HCG hormone. According to proponents of the diet, the HCG hormone, which occurs naturally in pregnant women, helps the body lose weight quickly and efficiently. When the hormone enters your body, it can suppress hunger, reduce muscle loss, and fix other hormone imbalances. A number of different HCG diet protocols exist, but most follow the same basic diet plan and phases.

During the main phase of the diet, you will follow the HCG 500 calorie diet meal plan. The dramatic drop in calories ensures that you lose weight quickly. The HCG diet meal plan, which was outlined in the book Pounds & Inches by Dr. A.T.W. Simeons, includes just two meals per day. You will start the day with coffee or tea in unlimited quantities for breakfast. In your beverage, you can use saccharin or stevia sweeteners and a single tablespoon of milk. Then, you will eat lunch and dinner at normal times. Both meals may be chosen from a list of specific foods that does not vary throughout the duration of the diet.

While you are following the 500 calorie HCG plan, your meal choices are limited. For lunch and dinner, you can choose one 100-gram serving of chicken breast, lobster, veal, shrimp, beef, crab, or fresh white fish. Before you cook the meat, you must remove all of the visible fat. The 100 grams refers to the raw weight of the meat. You can also choose one vegetable from the following list: asparagus, celery, green salad, spinach, cabbage, chard, red radishes, chicory, beet-greens, tomatoes, cucumbers, fennel, and onions. In addition, you can have one Melba toast or a single breadstick. To close out the meal, you can choose from an apple, a half of a grapefruit, a handful of strawberries, or an orange. If you like, you can eat the breadstick or the fruit as a snack between meals. The meal options stay the same until you are finished with the main phase of the diet.

In addition to the regular lunch and dinner foods, the HCG meal plan allows you to use the juice of a single lemon each day. While you are cooking, you can use almost any type of spice, garlic, and vinegar, but you may not use butter, oil, or any type of dressing. The diet permits you to drink water, coffee, and tea in any quantity throughout the day. As a guide, you should aim for approximately two liters of fluid each day.

Given the limited number of allotted calories on the HCG diet meal plan, excellent recipes are crucial to success. For lunch, you might make an apple chicken salad with cooked chicken, a diced apple, and diced celery, mixed with lemon juice, cinnamon, nutmeg, cardamom, salt, and stevia to taste. At dinner, you could have roasted white fish paired with pickles made from a cucumber, garlic, vinegar, lemon juice, and salt. If you are struggling to find recipes that add flavor to your meat and vegetables, try making HCG-friendly sauces and marinades. For a sauce that makes a dressing or a marinade, mix fresh dill, lemon juice, vinegar, Old Bay seasoning, and salt. Or, make your own mustard using mustard powder, garlic powder, onion powder, ginger, vinegar, water, lemon juice, and stevia.

Phase Zero: Pre-diet CleanseSome variations of the HCG diet preface the four phases of the HCG diet with a cleanse or detox. Although it is not necessary or required, a cleanse diet can help prepare your body and mind for the HCG diet phases. Any type of cleanse will work. If you want an extreme detoxification, you can choose a candida cleanse or a colon cleanse. For a less extreme option, you can spend a week eliminating all processed foods from your diet.

Phase OneDuring the first phase of the HCG diet, you increase your caloric and fat intakes for two days, focusing on high-fat foods. At the same time, you will take HCG injections. The goal of the first phase is to interfere with the way the body stores fat. The HCG will prevent the fat from accumulating in your body, which begins the process of lipid mobilization.

Phase TwoOn the third day of the HCG diet, youll begin the second phase. At this point, you will drop your diet down to the 500-calorie regimen, eating only the foods outlined in the Simeons protocol. You will also continue with the HCG injection. The second phase can be difficult, particularly at the beginning. The length of this phase depends on how much weight you have to lose. At a minimum, you should stick with the plan through twenty-three doses of HCG; this lower limit is for people who want to lose fifteen or fewer pounds. At a maximum, you can stay in the second phase until youve reached forty doses of HCG. You should plan the specific dosage with your doctor. After youre finished with the HCG, you must remain on the 500-calorie diet for three days.

Phase ThreeDuring the third phase of the HCG diet, which lasts three to four weeks, you will maintain your new weight. Some variations of the HCG diet advise you to avoid starches and sugars during the third phase; others require that you avoid milk and excessive fat. After a minimum of twenty-three days, you can begin a new round of HCG. Otherwise, you will move on to the last phase.

Phase FourThe final phase of the HCG diet involves maintaining your weight. Depending on your size and physiology, you will need to eat enough calories to prevent further weight loss or gain. Your caloric intake will usually fall somewhere between 1,500 and 2,500 calories per day; your doctor can help you determine the ideal intake level. Although you will not need to follow the HCG diet meal plan, it is safest to eat clean, unprocessed foods while you maintain your weight.

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Apr 21

Buy Sermorelin peptide online. Sermorelin for sale.

What is Sermorelin

Sermorelin acetate is a peptide analog of Growth Hormone-Releasing Hormone (GHRH) useful for diagnostic purposes and anti-aging treatment. Its function is the stimulation of growth hormone and seems to be a good alternative to synthetic growth hormone (HGH), which can cause adverse effects on pituitary function and it is only allowed in special cases like deficiency of this hormone on children and adults or individuals with AIDS.

Sermorelin is not a substitute for the human growth hormone (HGH) produced by the pituitary, rather it is a promoter of its natural production. The increase of HGH is accomplished by the stimulation of the pituitary giving, as a result, some benefits to individuals during the aging process.

Sermorelin promotes healthy function of the pituitary by binding to a specific receptor to increase production and secretion of endogenous HGH. The pituitary is an endocrine gland located in the hypothalamus at the base of the brain. It secretes hormones that control growth, blood pressure, the function of sex organs, thyroid glands, metabolism, pregnancy, childbirth, temperature and pain relief among others.

The main difference between Sermorelin and synthetic HGH are the side effects on bone and tissue growth abnormalities, diabetes, heart disease and cancer, whereas Sermorelin does not have any of these adverse effects. Nevertheless, people who use it may have temporary pain, redness, swelling at the place of injection, itching, and trouble in swallowing.

Sermorelin helps in the improvement of a wide variety of the body functions such as muscle mass, the bone mineral density and hence, muscle strength, exercise performance, the metabolic function, energy, libido and sexual performance, and even the improvement of quality life in general. An additional benefit in the use of Sermorelin is the stimulation of fat reduction.

This peptide can regulate the immune function, which is the protection process of an organism against diseases. This function detects any type of threats to start its self-defense and eliminate them.

Sermorelin can help in the prevention of joint deterioration and heart disease. People with arthritis can be benefited by positive results that this peptide brings in the regeneration of joint. Heart disease is related to growth hormone deficiency but if this hormone is reestablished to its optimal levels, heart health can be improved.

Although there is not enough evidence of carcinogen effects of Sermorelin, it is known that RHGH is a mitogenic hormone that can awaken latent cancers. A mitogen promotes the cell division by mitosis, which is the generation of two identical sets of chromosomes originates by a unique original chromosome contained in a cell nucleus; this process, along with by cytokinesis generates the cellular reproduction.

Some people are afraid of developing diabetes due to the use of Sermorelin but this has not been proved by the case studies, although it has been observed that improper doses of RHGH promote metabolic disorders by the alteration of chemical reactions in the body, which could generate temporary symptoms like lethargy, weight loss, jaundice, seizures or more severe permanent symptoms like diabetes.

It is important that medicated people follow their doctors instructions with accuracy because depending on the problem, doses will be suited in quantity, frequency and period.

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Apr 19

2 Numbers That Explain Why Planet Fitness Is Growing So …

Most mornings, I head to a Planet Fitness (NYSE:PLNT) to do a short workout, and I'm never, ever alone. Approximately 12.5 million members like me pay at least $10 monthly to enter one of the 1,742 locations Planet Fitness brands as a "judgment free zone."

I'm not a typical gym rat and don't want the typical gym rat experience. Good cardio and minimal weight training to keep my body functional is all I'm after. Planet Fitness gets paid well to offer that experience. The only is question is, can the good times last? Two numbers -- store growth, and equipment sales as a percentage of revenue -- may give an early warning sign if the business begins to go south.

Planet Fitness is bulking up across the land. Image source: Planet Fitness.

After three consecutive years of decelerating growth, Planet Fitness' revenue jumped 23.4% in 2018 as net margin hit a five-year high of 16.6%. Management also produces a handsome 17.1% return on capital, testifying to the team's skill at putting money to work for growing the business effectively. No wonder the stock is up over 350% over the past three years. The business is firing on all cylinders, or so it seems.

If there's a worry here, it's on the balance sheet. There, you'll find Planet Fitness saddled with $1.172 billion in debt versus $289.4 million in cash and investments. That's a wide gulf, and it would become insurmountable if the company wasn't producing plenty of excess free cash flow. Fortunately, Planet Fitness generated $143.5 million in free cash flow last year, more than enough to pay interest and taxes and still have money left over to reinvest in the business.

Actually, that may be underselling it. Planet Fitness improved its cash from operations by $53.4 million, or 40.8%, from 2017 to 2018. Capital expenditures inched up just $3.2 million, or 8.5%, over the same period. That's serious leverage, and it explains why management seems comfortable taking on debt.

All the debt has to go somewhere and since Planet Fitness is a franchisor, it's likely going to two places: regional company-owned stores that anchor the business in an area and show potential franchisees the power of the model, and fitness equipment to be resold to franchisees.

So far, the formula is working. Stores are popping up quickly and earning good returns, which gets cash flowing onto Planet Fitness's balance sheet. Taking on debt makes sense as long as the math behind the formula remains sound. Management seems convinced.

According to the fourth quarter investor presentation, executives believe Planet Fitness has room to more than double its store count to 4,000 locations in the U.S. and another 300 in Canada. If they're right, here's what we'll see:

However, if Planet Fitness slows its pace of store openings while dramatically boosting its sales of equipment to existing franchisees, it could signal the concept has worn thin and that Planet Fitness is poised for an extended slowdown.

That doesn't appear to be happening, and frankly, it may never happen. The point is that the risk is there, and as an investor, it's crucial to know what to look for -- in Planet Fitness or any business in which you're investing.

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Apr 19

FITNESS | meaning in the Cambridge English Dictionary

These examples are from the Cambridge English Corpus and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors.

The relative fitnesses are also scaled by the arbitrary assumption of a generation time l 15 days made when fitting the discrete model.

If the wild-type homozygote is viable and fertile, then it is impossible to infer the four fitnesses from the three chromosome frequencies alone.

346 sume the one-locus model of fitnesses given above.

However, locally stable polymorphisms are possible even if all double homozygotes have higher geometric mean fitnesses than all other genotypes.

If so, then mean fitnesses do not climb peaks in the adaptive topography.

The fitnesses of the heterozygotes and homozygotes for the disfavoured allele are 1khs and 1ks, respectively.

Offspring phenotypes and fitnesses are assigned as above.

Also, relative fitnesses might change through time, as a result of direct or indirect frequency-dependence.

When this is so, the interactions between the loci in fitnesses will be at least of the same order of magnitude as their individual effects.

Their results indicated that genetic background did not have a strong consistent effect on the adaptive evolution they studied; allelic fitnesses were not strongly dependent upon genetic background.

The numbers and effects of the mutations can then be estimated from the fitnesses of the replicates by means of a model of the mutational effects.

Dynamical behavior for population genetics models of differential and difference equations with nonmonotone fitnesses.

A straightforward, pragmatic solution is to allocate fitnesses and transmission rate parameters directly to combinations of genotypes and cultural traits, a package known as a phenogenotype.

The coevolution approach reformulates the given or intrinsic fitnesses by formulating extrinsic fitnesses that take into account a component's contribution to the assembly that uses it.

Note that because the fitnesses of the two hermaphrodite genotypes are identical when l=0, we need only consider the phenotypes involved to determine hermaphrodite invasion criteria.

See all examples of fitness

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Apr 19

Top 100 Fitness Blogs, Websites And Newsletters To Follow …

1. Men's Journal | Health, Adventure, Gear, Style

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Apr 18

Study shows how high-fat diets increase colon cancer risk …

Epidemiologists have long warned that, in addition to causing obesity, eating too much fat and sugar puts a person at greater risk for colon cancer. Now, researchers at Temple University have established a link that may explain why.

The findings, Epigenetic Differences in Normal Colon Mucosa of Cancer Patients Suggest Altered Dietary Metabolic Pathways, were published in the March issue of the American Association for Cancer Researchs journal, Cancer Prevention Research.

There have always been questions about why things like diet and obesity are independent risk factors for colon cancer, said Carmen Sapienza, professor of pathology in Temples Fels Institute for Cancer Research and Molecular Biology, the studys lead author. This study suggests how and why high fat diets are linked to colon cancer.

The researchers compared colon tissue in non-colon cancer patients with normal colon tissue in patients with the disease. In the normal tissue from patients with colon cancer, they found that epigenetic marks on genes involved in breaking down carbohydrates, lipids and amino acids abundant in the fatty Western diet appeared to have been retrained. Epigenetic marks are chemical modifications that serve as on/off switches for many genes.

These foods are changing the methylation patterns on a persons insulin genes so that they express differently, pumping out more insulin than the body requires, said Sapienza. In people that have colon cancer, their glucose metabolic pathways and insulin signaling pathways are running at completely different levels than people who dont have colon cancer.

Sapienza said that cancer cells love insulin and studies have shown that tumors feed off of insulin. Insulin is only supposed to be expressed in your pancreas, so having this extra insulin is bad, he said.

Sapienza pointed out that people dont usually get colon cancer until the age of 50 or older, so it is unclear when the epigenetic modification of the genes begins.

The hypothesis is that the changes in the metabolic pathways happen first, and once they occur, if any kind of mutation happens that causes a cancerous polyp, you are going to feed it through this excess insulin, he said.

There have always been questions about why things like diet and obesity are independent risk factors for colon cancer. This study suggests how and why high fat diets are linked to colon cancer.

-- Carmen Sapienza, professor of pathology, Fels Institute for Cancer Research and Molecular Biology

Sapienza said this study provides the first evidence of widespread epigenetic modification of metabolic pathway genes occurring in healthy colon tissue.

The researchers theorize that if the modification found in healthy colon tissue could also be found in other healthy tissues in the body, they might be used to diagnose or determine the likelihood of colon cancer by through a saliva or blood test in addition to a colonoscopy.

In addition to Sapienza, researchers om the study included Matthew L. Silviera, Brian P. Smith and Jasmine Powell of the Fels Institute for Cancer Researcher and Molecular Biology in Temples School of Medicine.

The study was funded through the National Institutes of Health and Temples Fels Institute for Cancer Research and Molecular Biology.

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Apr 18

Study will compare zero-calorie drinks versus water in …

Youve made a New Years resolution to lose weight in 2013, but should you favor zero-calorie drinks or water as part of your diet? Or does it matter at all which of these beverages you choose for weight loss?

Thats what researchers at Temple Universitys Center for Obesity Research and Education (CORE) and the University of Colorados Anschutz Health and Wellness Center are hoping to discover as part of a year-long study comparing the effects of zero-calorie drinks and water in the context of weight loss. The Food and Drug Administration defines zero-calorie drinks as those having five or fewer calories per eight-ounce serving.

Water has long been the recommended beverage in any weight loss/maintenance program, yet dieters frequently turn to the more flavorful diet or zero-calorie beverages as a replacement.

Since both of these drinks are calorie neutral, you should be able to lose the same amount of weight regardless of whether you consume zero-calorie drinks or water while dieting, said Stephanie Vander Veur, program director for clinical research at CORE. On the other hand, some think that non-nutritive sweetened beverages may increase a persons preference for a sweet taste that may lead them to consume additional calories. No one has really tested this to date.

Temple is seeking to recruit up to 150 people to take part in the study, which is being led by CORE Director Gary Foster. The first Temple group of 18 already began participating in the study in November. The University of Colorado will also study 150 participants.

Those who are selected to participate must be regular consumers of zero-calorie or diet beverages (currently consume a minimum of three per week) and above ideal body weight. They will participate in a weekly 60-minute group weight loss program during the first 12 weeks of the study and then 10 monthly 60-minute group weight loss/maintenance meetings thereafter.

Participants will be required to drink a minimum of 24 ounces per day of either a zero-calorie beverage that includes a non-nutritive sweetener such as Diet Coke, Coke Zero, Diet Pepsi, Pepsi Max, diet ginger ale, diet Snapple, and Vitaminwater zero or water, depending on which study group they are randomly assigned. Those who are in the water group will not be able to drink any zero-calorie beverages, and must also refrain from using non-nutritive sweeteners in other drinks such as coffee or tea. Foods that contain non-nutritive sweeteners are permitted.

The study will be conducted at CORE, located on Temples Health Sciences Campus in North Philadelphia, Jeanes Hospital in Northeast Philadelphia and Temples Center City campus.

The study is being funded by the American Beverage Association.

Anyone from the Philadelphia region interested in participating in the study should contact Temples Center for Obesity Research and Education at 215-707-3292.

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